Methods for improving the activity of δ-endotoxins against insect pests

ABSTRACT

Disclosed are methods for increasing the activity of B. thuringiensis  delta -endotoxins against Coleopteran insect pests. Also disclosed are methods for mutagenizing nucleic acid sequences encoding these polypeptides, and increasing insect resistance in transgenic plants expressing these genes.

1.0 BACKGROUND OF THE INVENTION

1.1 Field of the Invention

This invention relates to methods for producing genetically-engineered, recombinant δ-endotoxins derived from Bacillus thuringiensis that are useful in the control of southern corn rootworm (Diabrotica undecimpunctata howardi Barber) and western corn rootworm (Diabrotica virgifera virgifera LeConte).

1.2 Description of the Related Art

Almost all field crops, plants, and commercial farming areas are susceptible to attack by one or more insect pests. Particularly problematic are Coleopteran and Lepidoptern pests. For example, vegetable and cole crops such as artichokes, kohlrabi, arugula, leeks, asparagus, lentils, beans, lettuce (e.g., head, leaf, romaine), beets, bok choy, malanga, broccoli, melons (e.g., muskmelon, watermelon, crenshaw, honeydew, cantaloupe), brussels sprouts, cabbage, cardoni, carrots, napa, cauliflower, okra, onions, celery, parsley, chick peas, parsnips, chicory, peas, chinese cabbage, peppers, collards, potatoes, cucumber, pumpkins, cucurbits, radishes, dry bulb onions, rutabaga, eggplant, salsify, escarole, shallots, endive, soybean, garlic, spinach, green onions, squash, greens, sugar beets, sweet potatoes, turnip, swiss chard, horseradish, tomatoes, kale, turnips, and a variety of spices are sensitive to infestation by one or more of the following insect pests: alfalfa looper, armyworm, beet armyworm, artichoke plume moth, cabbage budworm, cabbage looper, cabbage webworm, corn earworm, celery leafeater, cross-striped cabbageworm, european corn borer, diamondback moth, green cloverworm, imported cabbageworm, melonworm, omnivorous leafroller, pickleworm, rindworm complex, saltmarsh caterpillar, soybean looper, tobacco budworm, tomato fruitworm, tomato hornworm, tomato pinworm, velvetbean caterpillar, and yellowstriped armyworm. Likewise, pasture and hay crops such as alfalfa, pasture grasses and silage are often attacked by such pests as armyworm, beef armyworm, alfalfa caterpillar, European skipper, a variety of loopers and webworms, as well as yellowstriped armyworms.

Fruit and vine crops such as apples, apricots, cherries, nectarines, peaches, pears, plums, prunes, quince almonds, chestnuts, filberts, pecans, pistachios, walnuts, citrus, blackberries, blueberries, boysenberries, cranberries, currants, loganberries, raspberries, strawberries, grapes, avocados, bananas, kiwi, persimmons, pomegranate, pineapple, tropical fruits are often susceptible to attack and defoliation by achema sphinx moth, amorbia, armyworm, citrus cutworm, banana skipper, blackheaded fireworm, blueberry leafroller, cankerworm, cherry fruitworm, citrus cutworm, cranberry girdler, eastern tent caterpillar, fall webworm, fall webworm, filbert leafroller, filbert webworm, fruit tree leafroller, grape berry moth, grape leaffolder, grapeleaf skeletonizer, green fruitworm, gummosos-batrachedra commosae, gypsy moth, hickory shuckworm, hornworms, loopers, navel orangeworm, obliquebanded leafroller, omnivorous leafroller, omnivorous looper, orange tortrix, orangedog, oriental fruit moth, pandemis leafroller, peach twig borer, pecan nut casebearer, redbanded leafroller, redhumped caterpillar, roughskinned cutworm, saltmarsh caterpillar, spanworm, tent caterpillar, thecla-thecla basillides, tobacco budworm, tortrix moth, tufted apple budmoth, variegated leafroller, walnut caterpillar, western tent caterpillar, and yellowstriped armyworm.

Field crops such as canola/rape seed, evening primrose, meadow foam, corn (field, sweet, popcorn), cotton, hops, jojoba, peanuts, rice, safflower, small grains (barley, oats, rye, wheat, etc.), sorghum, soybeans, sunflowers, and tobacco are often targets for infestation by insects including armyworm, asian and other corn borers, banded sunflower moth, beet armyworm, bollworm, cabbage looper, corn rootworm (including southern and western varieties), cotton leaf perforator, diamondback moth, european corn borer, green cloverworm, headmoth, headworm, imported cabbageworm, loopers (including Anacamptodes spp.), obliquebanded leafroller, omnivorous leaftier, podworm, podworm, saltmarsh caterpillar, southwestern corn borer, soybean looper, spotted cutworm, sunflower moth, tobacco budworm, tobacco hornworm, velvetbean caterpillar,

Bedding plants, flowers, ornamentals, vegetables and container stock are frequently fed upon by a host of insect pests such as armyworm, azalea moth, beet armyworm, diamondback moth, ello moth (hornworm), Florida fern caterpillar, Io moth, loopers, oleander moth, omnivorous leafroller, omnivorous looper, and tobacco budworm.

Forests, fruit, ornamental, and nut-bearing trees, as well as shrubs and other nursery stock are often susceptible to attack from diverse insects such as bagworm, blackheaded budworm, browntail moth, california oakworm, douglas fir tussock moth, elm spanworm, fall webwormn, fruittree leafroller, greenstriped mapleworm, gypsy moth, jack pine budworm, mimosa webworm, pine butterfly, redhumped caterpillar, saddleback caterpillar, saddle prominent caterpillar, spring and fall cankerworm, spruce budworm, tent caterpillar, tortrix, and western tussock moth. Likewise, turf grasses are often attacked by pests such as armyworm, sod webworm, and tropical sod webworm.

Because crops of commercial interest are often the target of insect attack, environmentally-sensitive methods for controlling or eradicating insect infestation are desirable in many instances. This is particularly true for farmers, nurserymen, growers, and commercial and residential areas which seek to control insect populations using eco-friendly compositions.

The most widely used environmentally-sensitive insecticidal formulations developed in recent years have been composed of microbial pesticides derived from the bacterium Bacillus thuringiensis. B. thuringiensis is a Gram-positive bacterium that produces crystal proteins or inclusion bodies which are specifically toxic to certain orders and species of insects. Many different strains of B. thuringiensis have been shown to produce insecticidal crystal proteins. Compositions including B. thuringiensis strains which produce insecticidal proteins have been commercially-available and used as environmentally-acceptable insecticides because they are quite toxic to the specific target insect, but are harmless to plants and other non-targeted organisms.

1.2.1 δ-Endotoxins

δ-endotoxins are used to control a wide range of leaf-eating caterpillars and beetles, as well as mosquitoes. These proteinaceous parasporal crystals, also referred to as insecticidal crystal proteins, crystal proteins, Bt inclusions, crystaline inclusions, inclusion bodies, and Bt toxins, are a large collection of insecticidal proteins produced by B. thuringiensis that are toxic upon ingestion by a susceptible insect host. Over the past decade research on the structure and function of B. thuringiensis toxins has covered all of the major toxin categories, and while these toxins differ in specific structure and function, general similarities in the structure and function are assumed. Based on the accumulated knowledge of B. thuringiensis toxins, a generalized mode of action for B. thuringiensis toxins has been created and includes: ingestion by the insect, solubilization in the insect midgut (a combination stomach and small intestine), resistance to digestive enzymes sometimes with partial digestion actually "activating" the toxin, binding to the midgut cells, formation of a pore in the insect cells and the disruption of cellular homeostasis (English and Slatin, 1992).

1.2.2 Genes Encoding Crystal Proteins

Many of the δ-endotoxins are related to various degrees by similarities in their amino acid sequences. Historically, the proteins and the genes which encode them were classified based largely upon their spectrum of insecticidal activity. The review by Hofte and Whiteley (1989) discusses the genes and proteins that were identified in B. thuringiensis prior to 1990, and sets forth the nomenclature and classification scheme which has traditionally been applied to B. thuringiensis genes and proteins. cryI genes encode lepidopterantoxic cryI proteins. cryII genes encode cryII proteins that are toxic to both lepidopterans and dipterans. cryIII genes encode coleopteran-toxic CryIII proteins, while cryIV genes encode dipteran-toxic CryIV proteins.

Based on the degree of sequence similarity, the proteins were further classified into subfamilies; more highly related proteins within each family were assigned divisional letters such as CryIA, cryIB, CryIC, etc. Even more closely related proteins within each division were given names such as CryIC1, CryIC2, etc.

Recently a new nomenclature was developed which systematically classified the Cry proteins based upon amino acid sequence homology rather than upon insect target specificities. The classification scheme for many known toxins, not including allelic variations in individual proteins, is summarized in Table 1.

                  TABLE 1                                                          ______________________________________                                         KNOWN B. THURINGIENSIS δ-ENDOTOXINS, GENBANK                             ACCESSION NUMBERS, AND REVISED NOMENCLATURE.sup.A                              New          Old         GenBank Accession #                                   ______________________________________                                         Cry1Aa1      CryIA(a)    M11250                                                Cry1Aa2      CryIA(a)    M10917                                                CryiAa3      CryIA(a)    D00348                                                Cry1Aa4      CryIA(a)    X13535                                                Cry1Aa5      CryIA(a)    D17518                                                Cry1Aa6      CryIA(a)    U43605                                                Cry1Ab1      CryIA(b)    M13898                                                Cry1Ab2      CryIA(b)    M12661                                                Cry1Ab3      CryIA(b)    M15271                                                Cry1Ab4      CryIA(b)    D00117                                                Cry1Ab5      CryIA(b)    X04698                                                Cry1Ab6      CryIA(b)    M37263                                                Cry1Ab7      CryIA(b)    X13233                                                Cry1Ab8      CryIA(b)    M16463                                                Cry1Ab9      CryIA(b)    X54939                                                Cry1Ab10     CryIA(b)                                                          Cry1Ac1      CryIA(c)    M11068                                                Cry1Ac2      CryIA(c)    M35524                                                Cry1Ac3      CryIA(c)    X54159                                                Cry1Ac4      CryIA(c)    M73249                                                Cry1Ac5      CryIA(c)    M73248                                                Cry1Ac6      CryIA(c)    U43606                                                Cry1Ac7      CryIA(c)    U87793                                                Cry1Ac8      CryIA(c)    U87397                                                Cry1Ac9      CryIA(c)    U89872                                                Cry1Ac10     CryIA(c)    AJ002514                                              Cry1Ad1      CryIA(d)    M73250                                                Cry1Ae1      CryIA(e)    M65252                                                Cry1Ba1      CryIB       X06711                                                Cry1Ba2                  X95704                                                Cry1Bb1      ET5         L32020                                                Cry1Bc1      CryIb(c)    Z46442                                                Cry1Bd1      CryE1                                                             Cry1Ca1      CryIC       X07518                                                Cry1Ca2      CryIC       X13620                                                Cry1Ca3      CryIC       M73251                                                Cry1Ca4      CryIC       A27642                                                Cry1Ca5      CryIC       X96682                                                Cry1Ca6      CryIC       X96683                                                Cry1Ca7      CryIC       X96684                                                Cry1Cb1      CryIC(b)    M97880                                                Cry1Da1      CryID       X54160                                                Cry1Db1      PrtB        Z22511                                                Cry1Ea1      CryIE       X53985                                                Cry1Ea2      CryIE       X56144                                                Cry1Ea3      CryIE       M73252                                                Cry1Ea4                  U94323                                                Cry1Eb1      CryIE(b)    M73253                                                Cry1Fa1      CryIF       M63897                                                Cry1Fa2      CryIF       M63897                                                Cry1Fb1      PrtD        Z22512                                                Cry1Ga1      PrtA        Z22510                                                Cry1Ga2      CryIM       Y09326                                                Cry1Gb1      CryH2                                                             Cry1Ha1      PrtC        Z22513                                                Cry1Hb1                  U35780                                                Cry1Ia1      CryV        X62821                                                Cry1Ia2      CryV        M98544                                                Cry1Ia3      CryV        L36338                                                Cry1Ia4      CryV        L49391                                                Cry1Ia5      CryV        Y08920                                                Cry1Ib1      CryV        U07642                                                Cry1Ja1      ET4         L32019                                                Cry1Jb1      ET1         U31527                                                Cry1Ka1                  U28801                                                Cry2Aa1      CryIIA      M31738                                                Cry2Aa2      CryIIA      M23723                                                Cry2Aa3                  D86084                                                Cry2Ab1      CryIIB      M23724                                                Cry2Ab2      CryIIB      X55416                                                Cry2Ac1      CryIIC      X57252                                                Cry3Aa1      CryIIIA     M22472                                                Cry3Aa2      CryIIIA     J02978                                                Cry3Aa3      CryIIIA     Y00420                                                Cry3Aa4      CryIIIA     M30503                                                Cry3Aa5      CryIIIA     M37207                                                Cry3Aa6      CryIIIA     U10985                                                Cry3Ba1      CryIIIB     X17123                                                Cry3Ba2      CryIIIB     A07234                                                Cry3Bb1      CryIIIB2    M89794                                                Cry3Bb2      CryIIIC(b)  U31633                                                Cry3Ca1      CryIIID     X59797                                                Cry4Aa1      CryIVA      Y00423                                                Cry4Aa2      CryIVA      D00248                                                Cry4Ba1      CryIVB      X07423                                                Cry4Ba2      CryIVB      X07082                                                Cry4Ba3      CryIVB      M20242                                                Cry4Ba4      CryIVB      D00247                                                Cry5Aa1      CryVA(a)    L07025                                                Cry5Ab1      CryVA(b)    L07026                                                Cry5Ba1      PS86Q3      U19725                                                Cry6Aa1      CryVIA      L07022                                                Cry6Ba1      CryVIB      L07024                                                Cry7Aa1      CryIIIC     M64478                                                Cry7Ab1      CryIIICb    U04367                                                Cry8Aa1      CryIIIE     U04364                                                Cry8Ba1      CryIIIG     U04365                                                Cry8Ca1      CryIIIF     U04366                                                Cry9Aa1      CryIG       X58120                                                Cry9Aa2      CryIG       X58534                                                Cry9Ba1      CryIX       X75019                                                Cry9Ca1      CryIH       Z37527                                                Cry9Da1      N141        D85560                                                Cry10Aa1     CryIVC      M12662                                                Cry11Aa1     CryIVD      M31737                                                Cry11Aa2     CryIVD      M22860                                                Cry11Ba1     Jeg80       X86902                                                Cry12Aa1     CryVB       L07027                                                Cry13Aa1     CryVC       L07023                                                Cry14Aa1     CryVD       U13955                                                Cry15Aa1     34kDa       M76442                                                Cry16Aa1     cbm71       X94146                                                Cry17Aa1     cbm71       X99478                                                Cry18Aa1     CryBP1      X99049                                                Cry19Aa1     Jeg65       Y08920                                                Cry20Aa1                 U82518                                                Cry21Aa1                 I32932                                                Cry22Aa1                 I34547                                                Cyt1Aa1      CytA        X03182                                                Cyt1Aa2      CytA        X04338                                                Cyt1Aa3      CytA        Y00135                                                Cyt1Aa4      CytA        M35968                                                Cyt1Ab1      CytM        X98793                                                Cyt1Ba1                  U37196                                                Cyt2Aa1      CytB        Z14147                                                Cyt2Ba1      "CytB"      U52043                                                Cyt2Ba2      "CytB"      AF020789                                              Cyt2Ba3      "CytB"      AF022884                                              Cyt2Ba4      "CytB"      AF022885                                              Cyt2Ba5      "CytB"      AF022886                                              Cyt2Bb1                  U82519                                                ______________________________________                                          .sup.a Adapted from: http://epunix.biols.susx.ac.uk/Home/Neil.sub.--           Crickmore/Bt/index.html                                                  

1.2.3 Bioinsecticide Polypeptide Compositions

The utility of bacterial crystal proteins as insecticides was extended beyond lepidopterans and dipteran larvae when the first isolation of a coleopteran-toxic B. thuringiensis strain was reported (Krieg et al., 1983; 1984). This strain (described in U.S. Pat. No. 4,766,203, specifically incorporated herein by reference), designated B. thuringiensis var. tenebrionis, is reported to be toxic to larvae of the coleopteran insects Agelastica alni (blue alder leaf beetle) and Leptinotarsa decemlineata (Colorado potato beetle).

U.S. Pat. No. 5,024,837 also describes hybridB. thuringiensis var. kurstaki strains which showed activity against lepidopteran insects. U.S. Pat. No. 4,797,279 (corresponding to EP 0221024) discloses a hybrid B. thuringiensis containing a plasmid from B. thuringiensis var. kurstaki encoding a lepidopteran-toxic crystal protein-encoding gene and a plasmid from B. thuringiensis tenebrionis encoding a coleopteran-toxic crystal protein-encoding gene. The hybrid B. thuringiensis strain produces crystal proteins characteristic of those made by both B. thuringiensis kurstaki and B. thuringiensis tenebrionis. U.S. Pat. No. 4,910,016 (corresponding to EP 0303379) discloses a B. thuringiensis isolate identified as B. thuringiensis MT 104 which has insecticidal activity against coleopterans and lepidopterans.

1.2.4 Molecular Genetic Techniques Facilitate Protein Engineering

The revolution in molecular genetics over the past decade has facilitated a logical and orderly approach to engineering proteins with improved properties. Site specific and random mutagenesis methods, the advent of polymerase chain reaction (PCR™) methodologies, and related advances in the field have permitted an extensive collection of tools for changing both amino acid sequence, and underlying genetic sequences for a variety of proteins of commercial, medical, and agricultural interest.

Following the rapid increase in the number and types of crystal proteins which have been identified in the past decade, researchers began to theorize about using such techniques to improve the insecticidal activity of various crystal proteins. In theory, improvements to δ-endotoxins should be possible using the methods available to protein engineers working in the art, and it was logical to assume that it would be possible to isolate improved variants of the wild-type crystal proteins isolated to date. By strengthening one or more of the aforementioned steps in the mode of action of the toxin, improved molecules should provide enhanced activity, and therefore, represent a breakthrough in the field. If specific amino acid residues on the protein are identified to be responsible for a specific step in the mode of action, then these residues can be targeted for mutagenesis to improve performance.

1.2.5 Structural Analyses of Crystal Proteins

The combination of structural analyses of B. thuringiensis toxins followed by an investigation of the function of such structures motifs, and the like has taught that specific regions of crystal protein endotoxins are, in a general way, responsible for particular functions.

Domain 1, for example, from Cry3Bb and Cry1Ac has been found to be responsible for ion channel activity, the initial step in formation of a pore (Walters el al., 1993; Von Tersch et al., 1994). Domains 2 and 3 have been found to be responsible for receptor binding and insecticidal specificity (Aronson et al., 1995; Caramori et al., 1991; Chen et al. 1993; de Maagd et al., 1996; Ge et al., 1991; Lee et al., 1992; Lee et al., 1995; Lu et al., 1994; Smedley and Ellar, 1996; Smith and Ellar, 1994; Rajamohan et al., 1995; Rajamohan et al., 1996; Wu and Dean, 1996). Regions in domain 2 and 3 can also impact the ion channel activity of some toxins (Chen et al., 1993, Wolfersberger et al., 1996; Von Tersch et al., 1994).

1.3 Deficiencies in the Prior Art

Unfortunately, while many laboratories have attempted to make mutated crystal proteins, few have succeeded in making mutated crystal proteins with improved lepidopteran toxicity. In almost all of the examples of genetically-engineered B. thuringiensis toxins in the literature, the biological activity of the mutated crystal protein is no better than that of the wild-type protein, and in many cases, the activity is decreased or destroyed altogether (Almond and Dean, 1993; Aronson et al., 1995; Chen et al., 1993, Chen et al., 1995; Ge et al., 1991; Kwak et al., 1995; Lu et al., 1994; Rajamohan et al., 1995; Rajamohan et al., 1996; Smedley and Ellar, 1996; Smith and Ellar, 1994; Wolfersberger et al., 1996; Wu and Aronson, 1992).

For a crystal protein having approximately 650 amino acids in the sequence of its active toxin, and the possibility of 20 different amino acids at each position in this sequence, the likelihood of arbitrarily creating a successful new structure is remote, even if a general function to a stretch of 250-300 amino acids can be assigned. Indeed, the above prior art with respect to crystal protein gene mutagenesis has been concerned primarily with studying the structure and function of the crystal proteins, using mutagenesis to perturb some step in the mode of action, rather than with engineering improved toxins.

Collectively, the limited successes in the art to develop synthetic toxins with improved insecticidal activity have stifled progress in this area and confounded the search for improved endotoxins or crystal proteins. Rather than following simple and predictable rules, the successful engineering of an improved crystal protein may involve different strategies, depending on the crystal protein being improved and the insect pests being targeted. Thus, the process is highly empirical.

Accordingly, traditional recombinant DNA technology is clearly not routine experimentation for providing improved insecticidal crystal proteins. What are lacking in the prior art are rational methods for producing genetically-engineered B. thuringiensis crystal proteins that have improved insecticidal activity and, in particular, improved toxicity towards a wide range of lepidopteran insect pests.

2.0 SUMMARY OF THE INVENTION

The present invention seeks to overcome these and other drawbacks inherent in the prior art by providing genetically-engineered modified B. thuringiensis δ-endotoxins (Cry*), and in particular modified Cry3 δ-endotoxins (designated Cry3* endotoxins). Also provided are nucleic acid sequences comprising one or more genes which encode such modified proteins. Particularly preferred genes include cry3* genes such as cry3A*, cry3B*, and cry3C* genes, particularly cry3B* genes, and more particularly, cry3Bb* genes, that encode modified crystal proteins having improved insecticidal activity against target pests.

Also disclosed are novel methods for constructing synthetic Cry3* proteins, synthetically-modified nucleic acid sequences encoding such proteins, and compositions arising therefrom. Also provided are synthetic cry3* expression vectors and various methods of using the improved genes and vectors. In a preferred embodiment, the invention discloses and claims Cry3B* proteins and cry3B* genes which encode improved insecticidal polypeptides.

In preferred embodiments, channel-forming toxin design methods are disclosed which have been used to produce a specific set of designed Cry3Bb* toxins with improved biological activity. These improved Cry3Bb* proteins are listed in Table 2 along with their respective amino acid changes from wild-type (WT) Cry3Bb, the nucleotide changes present in the altered cry3Bb* gene encoding the protein, the fold increase in bioactivity over WT Cry3Bb, the structural site of the alteration, and the design method(s) used to create the new toxins.

Accordingly, the present invention provides in an overall and general sense, mutagenized Cry3 protein-encoding genes and methods of making and using such genes. As used herein the term "mutagenized cry3 gene(s)" means one or more cry3 genes that have been mutagenized or altered to contain one or more nucleotide sequences which are not present in the wild type sequences, and which encode mutant Cry3 crystal proteins (Cry3*) showing improved insecticidal activity. Such mutagenized cry3 genes have been referred to in the Specification as cry3* genes. Exemplary cry3* genes include cry3A*, cry3B*, and cry3C* genes.

Exemplary mutagenized Cry3 protein-encoding genes include cry3B genes. As used herein the term "mutagenized cry3B gene(s)" means one or more genes that have been mutagenized or altered to contain one or more nucleotide sequences which are not present in the wild type sequences, and which encode mutant Cry3B crystal proteins (Cry3B*) showing improved insecticidal activity. Such genes have been designated cry3B* genes. Exemplary cry3B* genes include cry3Ba* and cry3Bb* genes, which encode Cry3Ba* and Cry3Bb* proteins, respectively.

Likewise, the present invention provides mutagenized Cry3A protein-encoding genes and methods of making and using such genes. As used herein the term "mutagenized cry3A gene(s)" means one or more genes that have been mutagenized or altered to contain one or more nucleotide sequences which are not present in the wild type sequences, and which encode mutant Cry3A crystal proteins (Cry3A*) showing improved insecticidal activity. Such mutagenized genes have been designated as cry3A* genes.

In similar fashion, the present invention provides mutagenized Cry3C protein-encoding genes and methods of making and using such genes. As used herein the term "mutagenized cry3C gene(s)" means one or more genes that have been mutagenized or altered to contain one or more nucleotide sequences which are not present in the wild type sequences, and which encode mutant Cry3C crystal proteins (Cry3C*) showing improved insecticidal activity. Such mutagenized genes have been designated as cry3C* genes.

Preferably the novel sequences comprise nucleic acid sequences in which at least one, and preferably, more than one, and most preferably, a significant number, of wild-type cry3 nucleotides have been replaced with one or more nucleotides, or where one or more nucleotides have been added to or deleted from the native nucleotide sequence for the purpose of altering, adding, or deleting the corresponding amino acids encoded by the nucleic acid sequence so mutagenized. The desired result, therefore, is alteration of the amino acid sequence of the encoded crystal protein to provide toxins having improved or altered activity and/or specificity compared to that of the unmodified crystal protein.

Examples of preferred Cry2Bb*-encoding genes include cry3Bb.60, cry3Bb.11221, cry3Bb.11222, cry3Bb.11223, cry3Bb.11224, cry3Bb.11225, cry3Bb.11226, cry3Bb.11227, cry3Bb.11228, cry3Bb.11229, cry3Bb.11230, cry3Bb.11231, cry3Bb.11232, cry3Bb.11233, cry3Bb.11234, cry3Bb.11235, cry3Bb.11236, cry3Bb.11237, cry3Bb.11238, cry3Bb.11239, cry3Bb.11241, cry3Bb.11242, cry3Bb.11032, cry3Bb.11035, cry3Bb.11036, cry3Bb.11046, cry3Bb.11048, cry3Bb.11051, cry3Bb.11057, cry3Bb.11058, cry3Bb.11081, cry3Bb.11082, cry3Bb.11083, cry3Bb.11084, cry3Bb.11095, and cry3Bb.11098.

                                      TABLE 2                                      __________________________________________________________________________     CRY3BB* PROTEINS EXHIBITING IMPROVED ACTIVITY AGAINST SCRW LARVAE              Cry3Bb*                                                                               cry3Bb*                              Fold   Design                      Protein                                                                               Plasmid                                                                              cry3Bb* Nucleotide Sequence                                                                   Cry3Bb* Amino                                                                          Structural Site                                                                        Increase Over                                                                         Method                      Designation                                                                           Designation                                                                          Changes        Acid Changes                                                                           of Changes                                                                             WT Activity                                                                           Used                        __________________________________________________________________________     Cry3Bb.60                                                                             --    --             Δ1-159                                                                           Δα1-α3                                                               3.6×                                                                            1, 6, 8                     Cry3Bb.11221                                                                          pEG1707                                                                              A460T, C461T, A462T, C464A,                                                                   T154F, P155H,                                                                          1α3,4                                                                            6.4×                                                                            1, 8                                     T465C, T466C, T467A, A468T,                                                                   L156H, L158R                                                    A469T, G470C, T472C, T473G,                                                    G474T, A477T, A478T, G479C                                        Cry3Bb.11222                                                                          pEG1708                                                                              T687C, T688C, A689T, C691A,                                                                   Y230L, H231S                                                                           α6                                                                               4.0×                                                                            3, 7                                     A692G                                                             Cry3Bb.11223                                                                          pEG1709                                                                              T667C, T687C, T688A, A689G,                                                                   S223P, Y230S                                                                           α6                                                                               2.8×                                                                            3                                        C691A, A692G                                                      Cry3Bb.11224                                                                          pEG1710                                                                              T687C, A692G   H231R   α6                                                                               5.0×                         Cry3Bb.11225                                                                          pEG1711                                                                              T687C, C691A   H231N, T241S                                                                           α6                                                                               3.6×                         Cry3Bb.11226                                                                          pEG1712                                                                              T687C, C691A, A692C, T693C                                                                    H231T   α6                                                                               3.0×                                                                            7, 8                        Cry3Bb.11227                                                                          pEG1713                                                                              C868A, G869A, G870T                                                                           R290N   1α7,β1                                                                      1.9×                                                                            2, 3, 4 6                   Cry3Bb.11228                                                                          pEG1714                                                                              C932T, A938C, T942G, G949A,                                                                   S311L, N313T,                                                                          1β1,α8                                                                      4.1×                                                                            2, 4                                     T954C          E317K                                              Cry3Bb.11229                                                                          pEG1715                                                                              T931A, A933C, T942A, T945A,                                                                   S311T, E317K,                                                                          1β1,α8                                                                      2.5×                                                                            2, 4                                     G949A, A953G, T954C                                                                           Y318C                                              Cry3Bb.11230                                                                          pEG1716                                                                              T931G, A933C, C934G, T945G,                                                                   S311A, L312V,                                                                          1β1,α8                                                                      4.7×                                                                            2, 4 8                                   C946T, A947G, G951A, T954C                                                                    Q316W                                              Cry3Bb.11231                                                                          pEG1717                                                                              T687C, A692G, C932T, A938C,                                                                   H231R, S311L,                                                                          α6; 1β1,α8                                                            7.9×                                                                            2, 4, 7, 8,                              T942G, G949A, T954C                                                                           N313T, E317K           10                          Cry3Bb.11232                                                                          pEG1718                                                                              T931A, A933G, T935C, T936A,                                                                   S311T, L312P,                                                                          1β1,α8                                                                      5.1×                                                                            4                                        A938C, T939C, T942C, T945A,                                                                   N313T, E317N                                                    G951T, T954C                                                      Cry3Bb.11233                                                                          pEG1719                                                                              T931G, A933C, T936G, T942C,                                                                   S311A, Q316D                                                                           1β1,α8                                                                      2.2×                                                                            2, 4                                     C943T, T945A, C946G, G948C,                                                    T954C                                                             Cry3Bb.11234                                                                          pEG1720                                                                              T861C, T866C, C868A, T871C,                                                                   I289T, L291R,                                                                          1α7,β1                                                                      4.1×                                                                            4                                        T872G, A875T, T877A, C878G,                                                                   Y292F, S293R                                                    A882G                                                             Cry3Bb.11235                                                                          pEG1721                                                                              T687C, A692G, C932T                                                                           H231R, S311L                                                                           α6; 1β1,α8                                                            3.2×                                                                            2, 4, 7, 8,                                                                    10                          Cry3Bb.11236                                                                          pEG1722                                                                              T931A, C932T, A933C, T936C,                                                                   S311I   1β1,α8                                                                      3.1×                                                                            2, 4                                     T942G, T945A, T954C                                               Cry3Bb.11237                                                                          pEG1723                                                                              T931A, C932T, A933C, T936C,                                                                   S311I, N313H                                                                           1β1,α8                                                                      5.4×                                                                            2, 4                                     A937G, A938T, C941A, T942C,                                                    T945A, C946A, A947T, A950T,                                                    T954C                                                             Cry3Bb.11238                                                                          pBG1724                                                                              A933C, T936C, A937G, A938T,                                                                   N313V, T314N,                                                                          1β1,α8                                                                      2.6×                                                                            2, 4                                     C941A, T942C, T945A, C946A,                                                                   Q316M, E317V                                                    A947T, A950T, T954C                                               Cry3Bb.11239                                                                          pEG1725                                                                              A933T, A938G, T939G, T942A,                                                                   N313R, L315P,                                                                          1β1,α8                                                                      2.8×                                                                            2, 4                                     T944C, T945A, A947T, G948T,                                                                   Q316L, E317A                                                    A950C, T954C                                                      Cry3Bb.11241                                                                          pBG1726                                                                              A860T, T861C, G862A, C868T,                                                                   Y287F, D288N,                                                                          1α7,β1                                                                      2.6×                                                                            2, 3, 4, 6                               G869T, T871C, A873T, T877A,                                                                   R290L                                                           C878G, A879T                                                      Cry3Bb.11242                                                                          pEG1727                                                                              C868G, G869T   R290V   1α7,β1                                                                      2.5×                                                                            2, 3, 4, 6,                                                                    8                           Cry3Bb.11032                                                                          pEG1041                                                                              A494G          D165G   α4                                                                               3.1×                                                                            2, 4, 8                     Cry3Bb.11035                                                                          pEG1046                                                                              G479A, A481C, A482C,                                                                          S160N, K161P,                                                                          α4                                                                               2.7×                                                                            8                                        A484C, G485A, A486C, A494G                                                                    P162H, D165G                                       Cry3Bb.11036                                                                          pEG1047                                                                              A865G, T877C   1289V, S293P                                                                           1α7,β1                                                                      4.3×                                                                            4                           Cry3Bb.11046                                                                          pEG1052                                                                              G479A, A481C, A482C,                                                                          S160N, K161P,                                                                          α4; 1α7,β1                                                            2.6×                                                                            2, 4, 8, 10                              A484C, G485A, A486C,                                                                          P162H, D165G,                                                   A494G, A865G, T877C                                                                           I289V, S293P                                       Cry3Bb.11048                                                                          pEG1054                                                                              T309A, Δ310, Δ311, Δ312                                                     D103E, ΔA104                                                                     1α2a,2b                                                                          4.3×                                                                            8                           Cry3Bb.11051                                                                          pEG1057                                                                              A565G, A566G   K189G   1α4,5                                                                            3.0×                                                                            2, 3, 4                     Cry3Bb.11057                                                                          pEG1062                                                                              T309A, Δ310, Δ311, Δ312,                                                    D103E, ΔA104,                                                                    1α2a,2b; α4                                                                3.4×                                                                            2, 4, 8, 10                              G479A, A481C, A482C,                                                                          S160N, K161P,                                                   A484C, G485A, A486C, A494G                                                                    P162H, D165G                                       Cry3Bb.11058                                                                          pEG1063                                                                              T309A, Δ310, Δ311, Δ312,                                                    D103E, ΔA104,                                                                    1α2a,2b; 1α3,4                                                             3.5×                                                                            1, 8, 10                                 A460T, C461T, A462T, C464A,                                                                   T154F, P155H,                                                   T465C, T466C, T467A, A468T,                                                                   L156H, L158R                                                    A469T, G470C, T472C, T473G,                                                    G474T, A477T, A478T, G479C                                        Cry3Bb.11081                                                                          pEG1084                                                                              A494G, T931A, A933C, T942A,                                                                   D165G, S311T,                                                                          α4; 1β1,α8                                                            6.1×                                                                            2, 4, 8, 10                              T945A, G949A, T954C                                                                           E317K                                              Cry3Bb.11082                                                                          pEG1085                                                                              A494G, A865G, T877C, T914C,                                                                   D165G, I289V,                                                                          α4; 1α7,β1;                                                           4.9×                                                                            2, 4, 5, 8                               T931G, A933C, C934G, T945G,                                                                   S293P, F305S,                                                                          1β1,α8; β2;                                                                   9, 10                                    C946T, A947G, G951A, T954C,                                                                   S311A, L312V,                                                                          β3b                                                A1043G, T1094C Q316W, Q348R,                                                                  V365A                                              Cry3Bb.11083                                                                          pEG1086                                                                              A865G, T877C, A1043G                                                                          1289V, S293P,                                                                          1α7,β1; β2                                                             7.4×                                                                            4, 5, 9, 10                                             Q348R                                              Cry3Bb.11084                                                                          pEG1087                                                                              A494G, C932T   D165G, S311L                                                                           α4; 1β1,                                                                    7.2×                                                                            2, 4, 8, 10                 Cry3Bb.11095                                                                          pEG1095                                                                              A1043G         Q348R   β2 4.6×                                                                            5, 9                        Cry3Bb.11098                                                                          pEG1098                                                                              A494G, T687C, A692G, C932T,                                                                   D165G, H231R,                                                                          α4; α6, 1β1,                                                  α8                                                                               7.9×                                                                            2, 4, 7, 8                               A938C, T942G, G949A, T954C                                                                    S311L, N313T,                                                                  E317K                                              __________________________________________________________________________

In a variety of illustrative embodiments, the inventors have shown remarkable success in generating toxins with improved insecticidal activity using these methods. In particular, the inventors have identified unique methods of analyzing and designing toxins having improved or enhanced insecticidal properties both in vitro and in vivo.

In addition to modifications of Cry3Bb peptides, those having benefit of the present teaching are now also able to make mutations in a variety of channel-forming toxins, and particularly in crystal proteins which are related to Cry3Bb either functionally or structurally. In fact, the inventors contemplate that any B. thuringiensis crystal protein or peptide can be analyzed using the methods disclosed herein and may be altered using the methods disclosed herein to produce crystal proteins having improved insecticidal specificity or activity. Alternatively, the inventors contemplate that those of skill in the art having the benefit of the teachings disclosed herein will be able to prepare not only mutated Cry3 toxins with improved activity, but also other crystal proteins including all of those proteins identified in Table 1, herein. In particular, the inventors contemplate the creation of Cry3* variants using one or more of the methods disclosed herein to produce toxins with improved activity. For example, the inventors note Cry3A, Cry3B, and Cry3C crystal proteins (which are known in the art) may be modified using one or more of the design strategies employed herein, to prepare synthetically-modified crystal proteins with improved properties. Likewise, one of skill in the art will even be able to utilize the teachings of the present disclosure to modify other channel forming toxins, including channel forming toxins other than B. thuringiensis crystal proteins, and even to modify proteins and channel toxins not yet described or characterized.

Because the structures for insecticidal crystal proteins show a remarkable conservation of protein tertiary structure (Grochulski et al., 1995), and because many crystal proteins show significant amino acid sequence identity to the Cry3Bb amino acid sequence within domain 1, including proteins of the cry1, Cry2, Cry3, Cry4, Cry5, Cry7, Cry8, Cry9, cry10, cry11, cry12, cry13, cry14, and cry16 classes (Table 1), now in light of the inventors' surprising discovery, for the first time, those of skill in the art having benefit of the teachings disclosed herein will be able to broadly apply the methods of the invention to modifying a host of crystal proteins with improved activity or altered specificity. Such methods will not only be limited to the insecticidal crystal proteins disclosed in Table 1, but may also been applied to any other related crystal protein, including those yet to be identified.

In particular, the high degree of homology between Cry3A, Cry3B, and Cry3C proteins is evident in the alignment of the primary amino acid sequence of the three proteins (FIG. 17A, FIG. 17B, and FIG. 17C).

As such, the disclosed methods may be now applied to preparation of modified crystal proteins having one or more alterations introduced using one or more of the mutational design methods as disclosed herein. The inventors further contemplate that regions may be identified in one or more domains of a crystal protein, or other channel forming toxin which may be similarly modified through site-specific or random mutagenesis to generate toxins having improved activity, or alternatively, altered specificity.

In certain applications, the creation of altered toxins having increased activity against one or more insects is desired. Alternatively, it may be desirable to utilize the methods described herein for creating and identifying altered insecticidal crystal proteins which are active against a wider spectrum of susceptible insects. The inventors further contemplate that the creation of chimeric insecticidal crystal proteins comprising one or more of these mutations may be desirable for preparing "super" toxins which have the combined advantages of increased insecticidal activity and concomitant broad spectrum activity.

In light of the present disclosure, the mutagenesis of one or more codons within the sequence of a toxin may result in the generation of a host of related insecticidal proteins having improved activity. While exemplary mutations have been described for each of the design strategies employed in the present invention, the inventors contemplate that mutations may also be made in insecticidal crystal proteins, including the loop regions, helices regions, active sites of the toxins, regions involved in protein oligomerization, and the like, which will give rise to functional bioinsecticidal crystal proteins. All such mutations are considered to fall within the scope of this disclosure.

In one illustrative embodiment, mutagenized cry3Bb* genes are obtained which encode Cry3Bb* variants that are generally based upon the wild-type Cry3Bb sequence, but that have one or more changes incorporated into the amino acid sequence of the protein using one or more of the design strategies described and claimed herein.

In these and other embodiments, the mutated genes encoding the crystal proteins may be modified so as to change about one, two, three, four, or five or so amino acids in the primary sequence of the encoded polypeptide. Alternatively even more changes from the native sequence may be introduced, such that the encoded protein may have at least about 1% or 2%, or alternatively about 3% or about 4%, or even about 5% to about 10%, or about 10% to about 15%, or even about 15% to about 20% or more of the codons either altered, deleted, or otherwise modified. In certain situations, it may even be desirable to alter substantially more of the primary amino acid sequence to obtain the desired modified protein. In such cases the inventors contemplate that from about 25%, to about 50%, or even from about 50% to about 75%, or more of the native (or wild-type) codons either altered, deleted, or otherwise modified. Alternatively, mutations in the amino acid sequences or underlying DNA gene sequences which result in the insertion or deletion of one or more amino acids within one or more regions of the crystal protein or peptide.

To effect such changes in the primary sequence of the encoded polypeptides, it may be desirable to mutate or delete one or more nucleotides from the nucleic acid sequences of the genes encoding such polypeptides, or alternatively, under certain circumstances to add one or more nucleotides into the primary nucleic acid sequence at one or more sites in the sequence. Frequently, several nucleotide residues may be altered to produce the desired polypeptide. As such, the inventors contemplate that in certain embodiments it may be desirable to alter only one, two, three, four, or five or so nucleotides in the primary sequence. In other embodiments, which more changes are desired, the mutagenesis may involve changing, deleting, or inserting 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or even 20 or so nucleotide residues in the gene sequence. In still other embodiments, one may desire to mutate, delete, or insert 21, 22, 23, 24, 25, 26, 27, 28, 29, 30-40, 40-50, 50-60, 60-70, 70-80, 80-90, or even 90-100, 150, 200, 250, 300, 350, 400, 450, or more nucleotides in the sequence of the gene in order to prepare a cry3* gene which produces a Cry3* polypeptide having the desired characteristics. In fact, any number of mutations, deletions, and/or insertions may be made in the primary sequence of the gene, so long as the encoded protein has the improved insecticidal activity or specificity characteristics described herein.

Changing a large number of the codons in the nucleotide sequence of an endotoxin-encoding gene may be particularly desirable and often necessary to achieve the desired results, particularly in the situation of "plantizing" a DNA sequence in order to express a DNA of non-plant origin in a transformed plant cell. Such methods are routine to those of skill in the plant genetics arts, and frequently many residues of a primary gene sequence will be altered to facilitate expression of the gene in the plant cell. Preferably, the changes in the gene sequence introduce no changes in the amino acid sequence, or introduce only conservative replacements in the amino acid sequence such that the polypeptide produced in the plant cell from the "plantized" nucleotide sequence is still fully functional, and has the desired qualities when expressed in the plant cell.

Genes and encoded proteins mutated in the manner of the invention may also be operatively linked to other protein-encoding nucleic acid sequences, or expressed as fusion proteins. Both N-terminal and C-terminal fusion proteins are contemplated. Virtually any protein- or peptide-encoding DNA sequence, or combinations thereof, may be fused to a mutated cry3* sequence in order to encode a fusion protein. This includes DNA sequences that encode targeting peptides, proteins for recombinant expression, proteins to which one or more targeting peptides is attached, protein subunits, domains from one or more crystal proteins, and the like. Such modifications to primary nucleotide sequences to enhance, target, or optimize expression of the gene sequence in a particular host cell, tissue, or cellular localization, are well-known to those of skill in the art of protein engineering and molecular biology, and it will be readily apparent to such artisans, having benefit of the teachings of this specification, how to facilitate such changes in the nucleotide sequence to produce the polypeptides and polynucleotides disclosed herein.

In one aspect, the invention discloses and claims host cells comprising one or more of the modified crystal proteins disclosed herein, and in particular, cells of B. thuringiensis strains EG11221, EG11222, EG11223, EG11224, EG11225, EG11226, EG11227, EG11228, EG11229, EG11230, EG11231, EG11232, EG11233, EG11234, EG11235, EG11236, EG11237, EG11238, EG11239, EG11241, EG11242, EGI111032, EG11035, EG11036, EG11046, EG11048, EG11051, EG11057, EG11058, EG11081, EG11082, EG11083, EG11084, EG11095, and EG11098 which comprise recombinant DNA segments encoding synthetically-modified Cry3Bb* crystal proteins which demonstrates improved insecticidal activity.

Likewise, the invention also discloses and claims cell cultures of B. thuringiensis EG11221, EG11222, EG11223, EG11224, EG11225, EG11226, EG11227, EG11228, EG11229, EG11230, EG11231, EG11232, EG11233, EG11234, EG11235, EG11236, EG11237, EG11238, EG11239, EG11241, EG11242, EG11032, EG11035, EG11036, EG11046, EG11048, FG11051, EG11057, EG11058, EG11081, EG11082, EG11083, EG11084, and EG11095, and 11098.

Such cell cultures may be biologically-pure cultures consisting of a single strain, or alternatively may be cell co-cultures consisting of one or more strains. Such cell cultures may be cultivated under conditions in which one or more additional B. thuringiensis or other bacterial strains are simultaneously co-cultured with one or more of the disclosed cultures, or alternatively, one or more of the cell cultures of the present invention may be combined with one or more additional B. thuringiensis or other bacterial strains following the independent culture of each. Such procedures may be useful when suspensions of cells containing two or more different crystal proteins are desired.

The subject cultures have been deposited under conditions that assure that access to the cultures will be available during the pendency of this patent application to one determined by the Commissioner of Patents and Trademarks to be entitled thereto under 37 C.F.R. §1.14 and 35 U.S.C. §122. The deposits are available as required by foreign patent laws in countries wherein counterparts of the subject application, or its progeny, are filed. However, it should be understood that the availability of a deposit does not constitute a license to practice the subject invention in derogation of patent rights granted by governmental action.

Further, the subject culture deposits will be stored and made available to the public in accord with the provisions of the Budapest Treaty for the Deposit of Microorganisms, i.e., they will be stored with all the care necessary to keep them viable and uncontaminated for a period of at least five years after the most recent request for the finishing of a sample of the deposit, and in any case, for a period of at least 30 (thirty) years after the date of deposit or for the enforceable life of any patent which may issue disclosing the cultures. The depositor acknowledges the duty to replace the deposits should the depository be unable to furnish a sample when requested, due to the condition of the deposits. Al restrictions on the availability to the public of the subject culture deposits will be irrevocably removed upon the granting of a patent disclosing them.

Cultures shown in Table 3 were deposited in the permanent collection of the Agricultural Research Service Culture Collection, Northern Regional Research Laboratory (NRRL) under the terms of the Budapest Treaty.

                  TABLE 3                                                          ______________________________________                                         STRAINS OF THE PRESENT INVENTION DEPOSITED UNDER                               THE TERMS OF THE BUDAPEST TREATY                                                                              Accession Number                                Strain  Deposit Date                                                                              Protein     (NRRL Number)                                   ______________________________________                                         EG11032 5/27/97    Cry3Bb.11032                                                                               B-21744                                         EG11035 5/27/97    Cry3Bb.11035                                                                               B-21745                                         EG11036 5/27/97    Cry3Bb.11036                                                                               B-21746                                         EG11037 5/27/97    Cry3Bb.11037                                                                               B-21747                                         EG11046 5/27/97    Cry3Bb.11046                                                                               B-21748                                         EG11048 5/27/97    Cry3Bb.11048                                                                               B-21749                                         EG11051 5/27/97    Cry3Bb.11051                                                                               B-21750                                         EG11057 5/27/97    Cry3Bb.11057                                                                               B-21751                                         EG11058 5/27/97    Cry3Bb.11058                                                                               B-21752                                         EG11081 5/27/97    Cry3Bb.11081                                                                               B-21753                                         EG11082 5/27/97    Cry3Bb.11082                                                                               B-21754                                         EG11083 5/27/97    Cry3Bb.11083                                                                               B-21755                                         EG11084 5/27/97    Cry3Bb.11084                                                                               B-21756                                         EG11095 5/27/97    Cry3Bb.11095                                                                               B-21757                                         EG11204 5/27/97    Cry3Bb.11204                                                                               B-21758                                         EG11221 5/27/97    Cry3Bb.11221                                                                               B-21759                                         EG11222 5/27/97    Cry3Bb.11222                                                                               B-21760                                         EG11223 5/27/97    Cry3Bb.11223                                                                               B-21761                                         EG11224 5/27/97    Cry3Bb.11224                                                                               B-21762                                         EG11225 5/27/97    Cry3Bb.11225                                                                               B-21763                                         EG11226 5/27/97    Cry3Bb.11226                                                                               B-21764                                         EG11227 5/27/97    Cry3Bb.11227                                                                               B-12765                                         EG11228 5/27/97    Cry3Bb.11228                                                                               B-12766                                         EG11229 5/27/97    Cry3Bb.11229                                                                               B-21767                                         EG11230 5/27/97    Cry3Bb.11230                                                                               B-21768                                         EG11231 5/27/97    Cry3Bb.11231                                                                               B-21769                                         EG11232 5/27/97    Cry3Bb.11232                                                                               B-12770                                         EG11233 5/27/97    Cry3Bb.11233                                                                               B-21771                                         EG11234 5/27/97    Cry3Bb.11234                                                                               B-21772                                         EG11235 5/27/97    Cry3Bb.11235                                                                               B-21773                                         EG11236 5/27/97    Cry3Bb.11236                                                                               B-21774                                         EG11237 5/27/97    Cry3Bb.11237                                                                               B-21775                                         EG11238 5/27/97    Cry3Bb.11238                                                                               B-21776                                         EG11239 5/27/97    Cry3Bb.11239                                                                               B-21777                                         EG11241 5/27/97    Cry3Bb.11241                                                                               B-21778                                         EG11242 5/27/97    Cry3Bb.11242                                                                               B-21779                                         ______________________________________                                    

Also disclosed are methods of controlling or eradicating an insect population from an environment. Such methods generally comprise contacting the insect population to be controlled or eradicated with an insecticidally-effective amount of a Cry3* crystal protein composition. Preferred Cry3* compositions include Cry3A*, Cry3B*, and Cry3C* polypeptide compositions, with Cry3B* compositions being particularly preferred. Examples of such polypeptides include proteins selected from the group consisting of Cry3Bb-60, Cry3Bb.11221, Cry3Bb.11222, Cry3Bb.11223, Cry3Bb.11224, Cry3Bb.11225, Cry3Bb.11226, Cry3Bb.11227, Cry3Bb.11228, Cry3Bb.11229, Cry3Bb.11230, Cry3Bb.11231, Cry3Bb.11232, Cry3Bb.11233, Cry3Bb.11234, Cry3Bb.11235, Cry3Bb.11236, Cry3Bb.11237, Cry3Bb.11238, Cry3Bb.11239, Cry3Bb.11241, Cry3Bb.11242, Cry3Bb.11032, Cry3Bb.11035, Cry3Bb.11036, Cry3Bb.11046, Cry3Bb.11048, Cry3Bb.11051, Cry3Bb.11057, Cry3Bb.11058, Cry3Bb.11081, Cry3Bb.11082, Cry3Bb.11083, Cry3Bb.11084, Cry3Bb.11095, and Cry3Bb.11098.

In preferred embodiments, these Cry3Bb* crystal protein compositions comprise the amino acid sequence of any of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6. SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14. SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102 or SEQ ID NO:108.

2.1 Methods for Producing Modified cry* Proteins

The modified Cry* polypeptides of the present invention are preparable by a process which generally involves the steps of obtaining a nucleic acid sequence encoding a Cry* polypeptide; analyzing the structure of the polypeptide to identify particular "target" sites for mutagenesis of the underlying gene sequence; introducing one or more mutations into the nucleic acid sequence to produce a change in one or more amino acid residues in the encoded polypeptide sequence; and expressing in a transformed host cell the mutagenized nucleic acid sequence under conditions effective to obtain the modified Cry* protein encoded by the cry* gene.

Means for obtaining the crystal structures of the polypeptides of the invention are well-known. Exemplary high resolution crystal structure solution sets are given in Section 9.0 of the disclosure, and include the crystal structure of both the Cry3A and Cry3B polypeptides disclosed herein. The information provided in Section 9.0 permits the analyses disclosed in each of the methods herein which rely on the 3D crystal structure information for targeting mutagenesis of the polypeptides to particular regions of the primary amino acid sequences of the δ-endotoxins to obtain mutants with increased insecticidal activity or enhanced insecticidal specificity.

A first method for producing a modified B. thuringiensis Cry3Bb δ-endotoxin having improved insecticidal activity or specificity disclosed herein generally involves obtaining a high-resolution 3D crystal structure of the endotoxin, locating in the crystal structure one or more regions of bound water wherein the bound water forms a contiguous hydrated surfaces separated by no more than about 16 Å; increasing the number of water molecules in this surface by increasing the hydrophobicity of one or more amino acids of the protein in the region; and obtaining the modified δ-endotoxin so produced. Exemplary δ-endotoxins include Cry3Bb.11032, Cry3Bb.11227, Cry3Bb.11241, Cry3Bb.11051, Cry3Bb.11242, and Cry3Bb.11098.

A second method for producing a modified B. thuringiensis Cry3Bb δ-endotoxin having improved insecticidal activity comprises identifying a loop region in a δ-endotoxin; modifying one or more amino acids in the loop to increase the hydrophobicity of the amino acids; and obtaining the modified δ-endotoxin so produced. Preferred δ-endotoxin produced by this method include Cry3Bb.11241, Cry3Bb.11242, Cry3Bb.11228, Cry3Bb.11229, Cry3Bb.11230, Cry3Bb.11231, Cry3Bb.11233, Cry3Bb.11236, Cry3Bb.11237, Cry3Bb.11238, and Cry3Bb.11239.

A method for increasing the mobility of channel forming helices of a B. thuringiensis Cry3B δ-endotoxin is also provided by the present invention. The method generally comprises disrupting one or more hydrogen bonds formed between a first amino acid of one or more of the channel forming helices and a second amino acid of the δ-endotoxin. The hydrogen bonds may be formed inter- or intramolecularly, and the disrupting may consist of replacing a first or second amino acid with a third amino acid whose spatial distance is greater than about 3 Å, or whose spatial orientation bond angle is not equal to 180±60 degrees relative to the hydrogen bonding site of the first or second amino acid. δ-endotoxins produced by this method and disclosed herein include Cry3Bb.11222, Cry3Bb.11223, Cry3Bb.11224, Cry3Bb.11225, Cry3Bb.11226, Cry3Bb.11227, Cry3Bb.11231, Cry3Bb.11241, and Cry3Bb.11242, and Cry3Bb.11098.

Also disclosed is a method of increasing the flexibility of a loop region in a channel forming domain of a B. thuringiensis Cry3Bb δ-endotoxin. This method comprises obtaining a crystal structure of a Cry3Bb δ-endotoxin having one or more loop regions; identifying the amino acids comprising the loop region; and altering one or more of the amino acids to reduce steric hindrance in the loop region, wherein the altering increases flexibility of the loop region in the δ-endotoxin. Examples of δ-endotoxins produced using this method include Cry3Bb.11032, Cry3Bb.11051, Cry3Bb.11228, Cry3Bb.11229, Cry3Bb.11230, Cry3Bb.11231, Cry3Bb.11232, Cry3Bb.11233, Cry3Bb.11236, Cry3Bb.11237, Cry3Bb.11238, Cry3Bb.11239, Cry3Bb.11227, Cry3Bb.11234, Cry3Bb.11241, Cry3Bb.11242, Cry3Bb.11036, and Cry3Bb.11098.

Another aspect of the invention is a method for increasing the activity of a δ-endotoxin, comprising reducing or eliminating binding of the δ-endotoxin to a carbohydrate in a target insect gut. The eliminating or reducing may be accomplished by removal of one or more α helices of domain 1 of the δ-endotoxin, for example, by removal of α helices α1, α2a/b, and α3. An exemplary δ-endotoxin produced using the method is Cry3Bb.60.

Alternatively, the reducing or eliminating may be accomplished by replacing one or more amino acids within loop β1,α8, with one or more amino acids having increased hydrophobicity. Such a method gives rise to δ-endotoxins such as Cry3Bb.11228, Cry3Bb.11230, Cry3B.11231, Cry3Bb.11237, and Cry3Bb.11098, which are described in detail, herein.

Alternatively, the reducing or eliminating is accomplished by replacing one or more specific amino acids, with any other amino acid. Such replacements are described in Table 2, and in the examples herein. One example is the δ-endotoxin designated herein as Cry3Bb.11221.

A method of identifying a region of a Cry3Bb δ-endotoxin for targeted mutagenesis comprising: obtaining a crystal structure of the δ-endotoxin; identifying from the crystal structure one or more surface-exposed amino acids in the protein; randomly substituting one or more of the surface-exposed amino acids to obtain a plurality of mutated polypeptides, wherein at least 50% of the mutated polypeptides have diminished insecticidal activity; and identifying from the plurality of mutated polypeptides one or more regions of the Cry3Bb δ-endotoxin for targeted mutagenesis. The method may further comprise determining the amino acid sequences of a plurality of mutated polypeptides having diminished activity, and identifying one or more amino acid residues required for insecticidal activity.

In another embodiment, the invention provides a process for producing a Cry3Bb δ-endotoxin having improved insecticidal activity. The process generally involves the steps of obtaining a high-resolution crystal structure of the protein; determining the electrostatic surface distribution of the protein; identifying one or more regions of high electrostatic diversity; modifying the electrostatic diversity of the region by altering one or more amino acids in the region; and obtaining a Cry3Bb δ-endotoxin which has improved insecticidal activity. In one embodiment, the electrostatic diversity may be decreased relative to the electrostatic diversity of a native Cry3Bb δ-endotoxin. Exemplary δ-endotoxins with decreased electrostatic diversity include Cry3Bb.11227, Cry3Bb.11241, and Cry3Bb.11242. Alternatively, the electrostatic diversity may be increased relative to the electrostatic diversity of a native Cry3Bb δ-endotoxin. An exemplary δ-endotoxin with increased electrostatic diversity is Cry3Bb.11234.

Furthermore, the invention also provides a method of producing a Cry3Bb δ-endotoxin having improved insecticidal activity which involves obtaining a high-resolution crystal structure; identifying the presence of one or more metal binding sites in the protein; altering one or more amino acids in the binding site; and obtaining an altered protein, wherein the protein has improved insecticidal activity. The altering may involve the elimination of one or more metal binding sites. Exemplary δ-endotoxin include Cry3Bb.11222, Cry3Bb.11224, Cry3Bb.11225, and Cry3Bb.11226.

A further aspect of the invention involves a method of identifying a B. thuringiensis Cry3Bb δ-endotoxin having improved channel activity. This method in an overall sense involves obtaining a Cry3Bb δ-endotoxin suspected of having improved channel activity; and determining one or more of the following characteristics in the δ-endotoxin, and comparing such characteristics to those obtained for the wild-type unmodified δ-endotoxin: (1) the rate of channel formation, (2) the rate of growth of channel conductance or (3) the duration of open channel state. From this comparison, one may then select a δ-endotoxin which has an increased rate of channel formation compared to the wildtype δ-endotoxin. Examples of Cry3Bb δ-endotoxins prepared by this method include Cry3Bb.60, Cry3Bb.11035, Cry3Bb.11048, Cry3Bb.11032, Cry3Bb.11223, Cry3Bb.11224, Cry3Bb.11226, Cry3Bb.11221, Cry3Bb.11242, Cry3Bb.11230, and Cry3Bb.11098.

Also provided is a method for producing a modified Cry3Bb δ-endotoxin, having improved insecticidal activity which involves altering one or more non-surface amino acids located at or near the point of greatest convergence of two or more loop regions of the Cry3Bb δ-endotoxin, such that the altering decreases the mobility of one or more of the loop regions. The mobility may conveniently be determined by comparing the thermal denaturation of the modified protein to a wild-type Cry3Bb δ-endotoxin. An exemplary crystal protein produced by this method is Cry3Bb.11095.

A further aspect of the invention involves a method for preparing a modified Cry3Bb δ-endotoxin, having improved insecticidal activity comprising modifying one or more amino acids in the loop to increase the hydrophobicity of said amino acids; and altering one or more of said amino acids to reduce steric hindrance in the loop region, wherein the altering increases flexibility of the loop region in the endotoxin. Exemplary Cry3Bb δ-endotoxins produced is selected from the group consisting of Cry3Bb.11057, Cry3Bb.11058, Cry3Bb.11081, Cry3Bb.11082, Cry3Bb.11083, Cry3Bb.11084, Cry3Bb.11231, Cry3Bb.11235, and Cry3Bb.11098.

The invention also provides a method of improving the insecticidal activity of a B. thuringiensis Cry3Bb δ-endotoxin, which generally comprises inserting one or more protease sensitive sites into one or more loop regions of domain 1 of the δ-endotoxin. Preferably, the loop region is α3,4, and an exemplary δ-endotoxin so produced is Cry3Bb.11221.

2.2 Polypeptide Compositions

The crystal proteins so produced by each of the methods described herein also represent important aspects of the invention. Such crystal proteins preferably include a protein or peptide selected from the group consisting of Cry3Bb-60, Cry3Bb.11221, Cry3Bb.11222, Cry3Bb.11223, Cry3Bb.11224, Cry3Bb.11225, Cry3Bb.11226, Cry3Bb.11227, Cry3Bb.11228, Cry3Bb.11229, Cry3Bb.11230, Cry3Bb.11231, Cry3Bb.11232, Cry3Bb.11233, Cry3Bb.11234, Cry3Bb.11235, Cry3Bb.11236, Cry3Bb.11237, Cry3Bb.11238, Cry3Bb.11239, Cry3Bb.11241, Cry3Bb.11242, Cry3Bb.11032, Cry3Bb.11035, Cry3Bb.11036, Cry3Bb.11046, Cry3Bb.11048, Cry3Bb.11051, Cry3Bb.11057, Cry3Bb.11058, Cry3Bb.11081, Cry3Bb.11082, Cry3Bb.11083, Cry3Bb.11084, Cry3Bb.11095, and Cry3Bb.11098.

In preferred embodiments, the protein comprises a contiguous amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6. SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14. SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, and SEQ ID NO:108.

Highly preferred are those crystal proteins which are encoded by the nucleic acid sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5. SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13. SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:101; or SEQ ID NO:107, or a nucleic acid sequence which hybridizes to the nucleic acid sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5. SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13. SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:101, or SEQ ID NO:107 under conditions of moderate stringency.

Amino acid, peptide and protein sequences within the scope of the present invention include, and are not limited to the sequences set forth in SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22 SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46 SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, and SEQ ID NO:108, and rations in the amino acid sequences including alterations, deletions, mutations, and homologs.

Compositions which comprise from about 0.5% to about 99% by weight of the crystal protein, or more preferably from about 5% to about 75%, or from about 25% to about 50% by weight of the crystal protein are provided herein. Such compositions may readily be prepared using techniques of protein production and purification well-known to those of skill, and the methods disclosed herein. Such a process for preparing a Cry3Bb* crystal protein generally involves the steps of culturing a host cell which expresses the Cry3Bb* protein (such as a B. thuringiensis EG11221, EG11222, EG11223, EG11224, EG11225, EG11226, EG11227, EG11228, EG11229, EG11230, EG11231, EG11232, EG11233, EG11234, EG11235, EG11236, EG11237, EG11238, EG11239, EG11241, EG11242, EG11032, EG11035, EG11036, EG11046, EG11048, EG11051, EG11057, EG11058, EG11081, EG11082, EG11083, EG11084, EG11095, or EG11098 cell) under conditions effective to produce the crystal protein, and then obtaining the crystal protein so produced.

The protein may be present within intact cells, and as such, no subsequent protein isolation or purification steps may be required. Alternatively, the cells may be broken, sonicated, lysed, disrupted, or plasmolyzed to free the crystal protein(s) from the remaining cell debris. In such cases, one may desire to isolate, concentrate, or further purify the resulting crystals containing the proteins prior to use, such as, for example, in the formulation of insecticidal compositions. The composition may ultimately be purified to consist almost entirely of the pure protein, or alternatively, be purified or isolated to a degree such that the composition comprises the crystal protein(s) in an amount of from between about 0.5% and about 99% by weight, or in an amount of from between about 5% and about 95% by weight, or in an amount of from between about 15% and about 85% by weight, or in an amount of from between about 25% and about 75% by weight, or in an amount of from between about 40% and about 60% by weight etc.

2.3 Recombinant Vectors Expressing cry3* Genes

One important embodiment of the invention is a recombinant vector which comprises a nucleic acid segment encoding one or more of the novel B. thuringiensis crystal proteins disclosed herein. Such a vector may be transferred to and replicated in a prokaryotic or eukaryotic host, with bacterial cells being particularly preferred as prokaryotic hosts, and plant cells being particularly preferred as eukaryotic hosts.

In preferred embodiments, the recombinant vector comprises a nucleic acid segment encoding the amino acid sequence of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, or SEQ ID NO:108. Highly preferred nucleic acid segments are those which have the sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:101, or SEQ ID NO:107.

Another important embodiment of the invention is a transformed host cell which expresses one or more of these recombinant vectors. The host cell may be either prokaryotic or eukaryotic, and particularly preferred host cells are those which express the nucleic acid segment(s) comprising the recombinant vector which encode one or more B. thuringiensis crystal protein comprising modified amino acid sequences in one or more loop regions of domain 1, or between α helix 7 of domain 1 and β strand 1 of domain 2. Bacterial cells are particularly preferred as prokaryotic hosts, and plant cells are particularly preferred as eukaryotic hosts.

In an important embodiment, the invention discloses and claims a host cell wherein the modified amino acid sequences comprise one or more loop regions between α helices 1 and 2, α helices 2 and 3, α helices 3 and 4, α helices 4 and 5, α helices 5 and 6 or α helices 6 and 7 of domain 1, or between α helix 7 of domain 1 and β strand 1 of domain 2. A particularly preferred host cell is one that comprises the amino acid sequence of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, or SEQ ID NO:108, and more preferably, one that comprises the nucleic acid sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:101, or SEQ ID NO:107.

Bacterial host cells transformed with a nucleic acid segment encoding a modified Cry3Bb crystal protein according to the present invention are disclosed and claimed herein, and in particular, a B. thuringiensis cell having designation EG11221, EG11222, EG11223, EG11224, EG11225, EG11226, EG11227, EG11228, EG11229, EG11230, EG11231, EG11232, EG11233, EG11234, EG11235, EG11236, EG11237, EG11238, EG11239, EG11241, EG11242, EG11032, EG11035, EG11036, EG11046, EG11048, EG11051, EG11057, EG11058, EG11081, EG11082, EG11083, EG11084, EG11095, or EG11098.

In another embodiment, the invention encompasses a method of using a nucleic acid segment of the present invention that encodes a cry3Bb* gene. The method generally comprises the steps of: (a) preparing a recombinant vector in which the cry3Bb* gene is positioned under the control of a promoter; (b) introducing the recombinant vector into a host cell; (c) culturing the host cell under conditions effective to allow expression of the Cry3Bb* crystal protein encoded by said cry3Bb* gene; and (d) obtaining the expressed Cry3Bb* crystal protein or peptide.

A wide variety of ways are available for introducing a B. thuringiensis gene expressing a toxin into the microorganism host under conditions which allow for stable maintenance and expression of the gene. One can provide for DNA constructs which include the transcriptional and translational regulatory signals for expression of the toxin gene, the toxin gene under their regulatory control and a DNA sequence homologous with a sequence in the host organism, whereby integration will occur, and/or a replication system which is functional in the host, whereby integration or stable maintenance will occur.

The transcriptional initiation signals will include a promoter and a transcriptional initiation start site. In some instances, it may be desirable to provide for regulative expression of the toxin, where expression of the toxin will only occur after release into the environment. This can be achieved with operators or a region binding to an activator or enhancers, which are capable of induction upon a change in the physical or chemical environment of the microorganisms. For example, a temperature sensitive regulatory region may be employed, where the organisms may be grown up in the laboratory without expression of a toxin, but upon release into the environment, expression would begin. Other techniques may employ a specific nutrient medium in the laboratory, which inhibits the expression of the toxin, where the nutrient medium in the environment would allow for expression of the toxin. For translational initiation, a ribosomal binding site and an initiation codon will be present.

Various manipulations may be employed for enhancing the expression of the messenger RNA, particularly by using an active promoter, as well as by employing sequences, which enhance the stability of the messenger RNA. The transcriptional and translational termination region will involve stop codon(s), a terminator region, and optionally, a polyadenylation signal. A hydrophobic "leader" sequence may be employed at the amino terminus of the translated polypeptide sequence in order to promote secretion of the protein across the inner membrane.

In the direction of transcription, namely in the 5' to 3' direction of the coding or sense sequence, the construct will involve the transcriptional regulatory region, if any, and the promoter, where the regulatory region may be either 5' or 3' of the promoter, the ribosomal binding site, the initiation codon, the structural gene having an open reading frame in phase with the initiation codon, the stop codon(s), the polyadenylation signal sequence, if any, and the terminator region. This sequence as a double strand may be used by itself for transformation of a microorganism host, but will usually be included with a DNA sequence involving a marker, where the second DNA sequence may be joined to the toxin expression construct during introduction of the DNA into the host.

By a marker is intended a structural gene which provides for selection of those hosts which have been modified or transformed. The marker will normally provide for selective advantage, for example, providing for biocide resistance, e.g., resistance to antibiotics or heavy metals; complementation, so as to provide prototropy to an auxotrophic host, or the like. Preferably, complementation is employed, so that the modified host may not only be selected, but may also be competitive in the field. One or more markers may be employed in the development of the constructs, as well as for modifying the host. The organisms may be further modified by providing for a competitive advantage against other wild-type microorganisms in the field. For example, genes expressing metal chelating agents, e.g., siderophores, may be introduced into the host along with the structural gene expressing the toxin. In this manner, the enhanced expression of a siderophore may provide for a competitive advantage for the toxin-producing host, so that it may effectively compete with the wild-type microorganisms and stably occupy a niche in the environment.

Where no functional replication system is present, the construct will also include a sequence of at least 50 basepairs (bp), preferably at least about 100 bp, more preferably at least about 1000 bp, and usually not more than about 2000 bp of a sequence homologous with a sequence in the host. In this way, the probability of legitimate recombination is enhanced, so that the gene will be integrated into the host and stably maintained by the host. Desirably, the toxin gene will be in close proximity to the gene providing for complementation as well as the gene providing for the competitive advantage. Therefore, in the event that a toxin gene is lost, the resulting organism will be likely to also lost the complementing gene and/or the gene providing for the competitive advantage, so that it will be unable to compete in the environment with the gene retaining the intact construct.

A large number of transcriptional regulatory regions are available from a wide variety of microorganism hosts, such as bacteria, bacteriophage, cyanobacteria, algae, fungi, and the like. Various transcriptional regulatory regions include the regions associated with the trp gene, lac gene, gal gene, the λ_(L) and λ_(R) promoters, the tac promoter, the naturally-occurring promoters associated with the δ-endotoxin gene, where functional in the host. See for example, U.S. Pat. Nos. 4,332,898; 4,342,832; and 4,356,270 (each of which is specifically incorporated herein by reference). The termination region may be the termination region normally associated with the transcriptional initiation region or a different transcriptional initiation region, so long as the two regions are compatible and functional in the host.

Where stable episomal maintenance or integration is desired, a plasmid will be employed which has a replication system which is functional in the host. The replication system may be derived from the chromosome, an episomal element normally present in the host or a different host, or a replication system from a virus which is stable in the host. A large number of plasmids are available, such as pBR322, pACYC184, RSF1010, pR01614, and the like. See for example, Olson et al. (1982); Bagdasarian et al. (1981), Baum et al., 1990, and U.S. Pat. Nos. 4,356,270; 4,362,817; 4,371,625, and 5,441,884, each incorporated specifically herein by reference.

The B. thuringiensis gene can be introduced between the transcriptional and translational initiation region and the transcriptional and translational termination region, so as to be under the regulatory control of the initiation region. This construct will be included in a plasmid, which will include at least one replication system, but may include more than one, where one replication system is employed for cloning during the development of the plasmid and the second replication system is necessary for functioning in the ultimate host. In addition, one or more markers may be present, which have been described previously. Where integration is desired, the plasmid will desirably include a sequence homologous with the host genome.

The transformants can be isolated in accordance with conventional ways, usually employing a selection technique, which allows for selection of the desired organism as against unmodified organisms or transferring organisms, when present. The transformants then can be tested for pesticidal activity. If desired, unwanted or ancillary DNA sequences may be selectively removed from the recombinant bacterium by employing site-specific recombination systems, such as those described in U.S. Pat. No. 5,441,884 (specifically incorporated herein by reference).

2.4 cry3 DNA Segments

A B. thuringiensis cry3* gene encoding a crystal protein having one or more mutations in one or more regions of the peptide represents an important aspect of the invention. Preferably, the cry3* gene encodes an amino acid sequence in which one or more amino acid residues have been changed based on the methods disclosed herein, and particularly those changes which have been made for the purpose of altering the insecticidal activity or specificity of the crystal protein.

In accordance with the present invention, nucleic acid sequences include and are not limited to DNA, including and not limited to cDNA and genomic DNA, genes; RNA, including and not limited to mRNA and tRNA; antisense sequences, nucleosides, and suitable nucleic acid sequences such as those set forth in SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:100, or SEQ ID NO:107, and alterations in the nucleic acid sequences including alterations, deletions, mutations, and homologs capable of expressing the B. thuringiensis modified toxins of the present invention.

As such the present invention also concerns DNA segments, that are free from total genomic DNA and that encode the novel synthetically-modified crystal proteins disclosed herein. DNA segments encoding these peptide species may prove to encode proteins, polypeptides, subunits, functional domains, and the like of crystal protein-related or other non-related gene products. In addition these DNA segments may be synthesized entirely in vitro using methods that are well-known to those of skill in the art.

As used herein the term "DNA segment" refers to a DNA molecule that has been isolated free of total genomic DNA of a particular species. Therefore, a DNA segment encoding a crystal protein or peptide refers to a DNA segment that contains crystal protein coding sequences yet is isolated away from, or purified free from, total genomic DNA of the species from which the DNA segment is obtained, which in the instant case is the genome of the Gram-positive bacterial genus, Bacillus, and in particular, the species of Bacillus known as B. thuringiensis. Included within the term "DNA segment", are DNA segments and smaller fragments of such segments, and also recombinant vectors, including, for example, plasmids, cosmids, phagemids, phage, viruses, and the like.

Similarly, a DNA segment comprising an isolated or purified crystal protein-encoding gene refers to a DNA segment which may include in addition to peptide encoding sequences, certain other elements such as, regulatory sequences, isolated substantially away from other naturally occurring genes or protein-encoding sequences. In this respect, the term "gene" is used for simplicity to refer to a functional protein-, polypeptide- or peptide-encoding unit. As will be understood by those in the art, this functional term includes both genomic sequences, operon sequences and smaller engineered gene segments that express, or may be adapted to express, proteins, polypeptides or peptides.

"Isolated substantially away from other coding sequences" means that the gene of interest, in this case, a gene encoding a bacterial crystal protein, forms the significant part of the coding region of the DNA segment, and that the DNA segment does not contain large portions of naturally-occurring coding DNA, such as large chromosomal fragments or other functional genes or operon coding regions. Of course, this refers to the DNA segment as originally isolated, and does not exclude genes, recombinant genes, synthetic linkers, or coding regions later added to the segment by the hand of man.

Particularly preferred DNA sequences are those encoding Cry3Bb.60, Cry3Bb.11221, Cry3Bb.11222, Cry3Bb.11223, Cry3Bb.11224, Cry3Bb.11225, Cry3Bb.11226, Cry3Bb.11227, Cry3Bb.11228, Cry3Bb.11229, Cry3Bb.11230, Cry3Bb.11231, Cry3Bb.11232, Cry3Bb.11233, Cry3Bb.11234, Cry3Bb.11235, Cry3Bb.11236, Cry3Bb.11237, Cry3Bb.11238, Cry3Bb.11239, Cry3Bb.11241, Cry3Bb.11242, Cry3Bb.11032, Cry3Bb.11035, Cry3Bb.11036, Cry3Bb.11046, Cry3Bb.11048, Cry3Bb.11051, Cry3Bb.11057, Cry3Bb.11058, Cry3Bb.11081, Cry3Bb.11082, Cry3Bb.11083, Cry3Bb.11084, Cry3Bb.11095 and Cry3Bb.11098 crystal proteins, and in particular cry3Bb* genes such as cry3Bb.60, cry3Bb.11221, cry3Bb.11222, cry3Bb.11223, cry3Bb.11224, cry3Bb.11225, cry3Bb.11226, cry3Bb.11227, cry3Bb.11228, cry3Bb.11229, cry3Bb.11230, cry3Bb.11231, cry3Bb.11232, cry3Bb.11233, cry3Bb.11234, cry3Bb.11235, cry3Bb.11236, cry3Bb.11237, cry3Bb.11238, cry3Bb.11239, cry3Bb.11241, cry3Bb.11242, cry3Bb.11032, cry3Bb.11035, cry3Bb.11036, cry3Bb.11046, cry3Bb.11048, cry3Bb.11051, cry3Bb.11057, cry3Bb.11058, cry3Bb.11081, cry3Bb.11082, cry3Bb.11083 cry3Bb.11084, cry3Bb.11095 and cry3Bb.11098. In particular embodiments, the invention concerns isolated DNA segments and recombinant vectors incorporating DNA sequences that encode a Cry peptide species that includes within its amino acid sequence an amino acid sequence essentially as set forth in SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36. SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, or SEQ ID NO:108.

The term "a sequence essentially as set forth in SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, or SEQ ID NO:108" means that the sequence substantially corresponds to a portion of the sequence of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, or SEQ ID NO:108, and has relatively few amino acids that are not identical to, or a biologically functional equivalent of, the amino acids of any of these sequences. The term "biologically functional equivalent" is well understood in the art and is further defined in detail herein (e.g., see Illustrative Embodiments).

Accordingly, sequences that have between about 70% and about 75% or between about 75% and about 80%, or more preferably between about 81% and about 90%, or even more preferably between about 91% or 92% or 93% and about 97% or 98% or 99% amino acid sequence identity or functional equivalence to the amino acids of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SFQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102 or SEQ ID NO:108 will be sequences that are "essentially as set forth in SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, or SEQ ID NO:108."

It will also be understood that amino acid and nucleic acid sequences may include additional residues, such as additional N- or C-terminal amino acids or 5' or 3' sequences, and yet still be essentially as set forth in one of the sequences disclosed herein, so long as the sequence meets the criteria set forth above, including the maintenance of biological protein activity where protein expression is concerned. The addition of terminal sequences particularly applies to nucleic acid sequences that may, for example, include various non-coding sequences flanking either of the 5' or 3' portions of the coding region or may include various internal sequences, i.e., introns, which are known to occur within genes.

The nucleic acid segments of the present invention, regardless of the length of the coding sequence itself, may be combined with other DNA sequences, such as promoters, polyadenylation signals, additional restriction enzyme sites, multiple cloning sites, other coding segments, and the like, such that their overall length may vary considerably. It is therefore contemplated that a nucleic acid fragment of almost any length may be employed, with the total length preferably being limited by the ease of preparation and use in the intended recombinant DNA protocol.

For example, nucleic acid fragments may be prepared that include a short contiguous stretch encoding the peptide sequence disclosed in SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, or SEQ ID NO:108, or that are identical to or complementary to DNA sequences which encode the peptide disclosed in SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, or SEQ ID NO:108, and particularly the DNA segments disclosed in SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:101, or SEQ ID NO:107.

Highly preferred nucleic acid segments of the present invention comprise one or more cry genes of the invention, or a portion of one or more cry genes of the invention. For certain application, relatively small contiguous nucleic acid sequences are preferable, such as those which are about 14 or 15 or 16 or 17 or 18 or 19, or 20, or 30-50, 51-80, 81-100 or so nucleotides in length. Alternatively, in some embodiments, and particularly those involving preparation of recombinant vectors, transformation of suitable host cells, and preparation of transgenic plant cell, longer nucleic acid segments are preferred, particularly those that include the entire coding region of one or more cry genes. As such, the preferred segments may include those that are up to about 20,000 or so nucleotides in length, or alternatively, shorter sequences such as those about 19,000, about 18,000, about 17,000, about 16,000, about 15,000, about 14,000, about 13,000, about 12,000, 11,000, about 10,000, about 9,000, about 8,000, about 7,000, about 6,000, about 5,000, about 4,500, about 4,000, about 3,500, about 3,000, about 2,500, about 2,000, about 1,500, about 1,000, about 500, or about 200 or so base pairs in length. Of course, these numbers are not intended to be exclusionary of all possible intermediate lengths in the range of from about 20,000 to about 15 nucleotides, as all of these intermediate lengths are also contemplated to be useful, and fall within the scope of the present invention. It will be readily understood that "intermediate lengths", in these contexts, means any length between the quoted ranges, such as 14, 15, 16, 17, 18, 19, 20, etc.; 21, 22, 23, 24, 25, 26, 27, 28, 29, etc.; 30, 31, 32, 33, 34, 35, 36 . . . etc.; 40, 41, 42, 43, 44 . . . etc., 50, 51, 52, 53 . . . etc.; 60, 61, 62, 63 . . . etc., 70, 80, 90, 100, 110, 120, 130 . . . etc.; 200, 210, 220, 230, 240, 250 . . . etc.; including all integers in the entire range from about 14 to about 10,000, including those integers in the ranges 200-500; 500-1,000; 1,000-2,000; 2,000-3,000; 3,000-5,000 and the like.

In a preferred embodiment, the nucleic acid segments comprise a sequence of from about 1800 to about 18,000 base pair in length, and comprise one or more genes which encode a modified Cry3* polypeptide disclosed herein which has increased activity against Coleopteran insect pests.

It will also be understood that this invention is not limited to the particular nucleic acid sequences which encode peptides of the present invention, or which encode the amino acid sequence of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ I) NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, or SEQ ID NO:108, including the DNA sequences which are particularly disclosed in SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:101, or SEQ ID NO:107. Recombinant vectors and isolated DNA segments may therefore variously include the peptide-coding regions themselves, coding regions bearing selected alterations or modifications in the basic coding region, or they may encode larger polypeptides that nevertheless include these peptide-coding regions or may encode biologically functional equivalent proteins or peptides that have variant amino acids sequences.

The DNA segments of the present invention encompass biologically-functional, equivalent peptides. Such sequences may arise as a consequence of codon redundancy and functional equivalency that are known to occur naturally within nucleic acid sequences and the proteins thus encoded. Alternatively, functionally-equivalent proteins or peptides may be created via the application of recombinant DNA technology, in which changes in the protein structure may be engineered, based on considerations of the properties of the amino acids being exchanged. Changes designed by man may be introduced through the application of site-directed mutagenesis techniques, e.g., to introduce improvements to the antigenicity of the protein or to test mutants in order to examine activity at the molecular level.

If desired, one may also prepare fusion proteins and peptides, e.g., where the peptide-coding regions are aligned within the same expression unit with other proteins or peptides having desired functions, such as for purification or immunodetection purposes (e.g., proteins that may be purified by affinity chromatography and enzyme label coding regions, respectively).

Recombinant vectors form further aspects of the present invention. Particularly useful vectors are contemplated to be those vectors in which the coding portion of the DNA segment, whether encoding a full length protein or smaller peptide, is positioned under the control of a promoter. The promoter may be in the form of the promoter that is naturally associated with a gene encoding peptides of the present invention, as may be obtained by isolating the 5' non-coding sequences located upstream of the coding segment or exon, for example, using recombinant cloning and/or PCR™ technology, in connection with the compositions disclosed herein.

2.5 Vectors, Host Cells, and Protein Expression

In other embodiments, it is contemplated that certain advantages will be gained by positioning the coding DNA segment under the control of a recombinant, or heterologous, promoter. As used herein, a recombinant or heterologous promoter is intended to refer to a promoter that is not normally associated with a DNA segment encoding a crystal protein or peptide in its natural environment. Such promoters may include promoters normally associated with other genes, and/or promoters isolated from any bacterial, viral, eukaryotic, or plant cell. Naturally, it will be important to employ a promoter that effectively directs the expression of the DNA segment in the cell type, organism, or even animal, chosen for expression. The use of promoter and cell type combinations for protein expression is generally known to those of skill in the art of molecular biology, for example, see Sambrook et al., 1989. The promoters employed may be constitutive, or inducible, and can be used under the appropriate conditions to direct high level expression of the introduced DNA segment, such as is advantageous in the large-scale production of recombinant proteins or peptides. Appropriate promoter systems contemplated for use in high-level expression include, but are not limited to, the Pichia expression vector system (Pharmacia LKB Biotechnology).

In connection with expression embodiments to prepare recombinant proteins and peptides, it is contemplated that longer DNA segments will most often be used, with DNA segments encoding the entire peptide sequence being most preferred. However, it will be appreciated that the use of shorter DNA segments to direct the expression of crystal peptides or epitopic core regions, such as may be used to generate anti-crystal protein antibodies, also falls within the scope of the invention. DNA segments that encode peptide antigens from about 8, 9, 10, or 11 or so amino acids, and up to and including those of about 30, 40, or 50 or so amino acids in length, or more preferably, from about 8 to about 30 amino acids in length, or even more preferably, from about 8 to about 20 amino acids in length are contemplated to be particularly useful. Such peptide epitopes may be amino acid sequences which comprise contiguous amino acid sequence from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, or SEQ ID NO:108.

2.6 Transformed Host Cells and Transgenic Plants

In one embodiment, the invention provides a transgenic plant having incorporated into its genome a transgene that encodes a contiguous amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6. SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14. SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, SEQ ID NO:102, and SEQ ID NO:108.

A further aspect of the invention is a transgenic plant having incorporated into its genome a cry3Bb* transgene, provided the transgene comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5. SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13. SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:101, and SEQ ID NO:107. Also disclosed and claimed are progeny of such a transgenic plant, as well as its seed, progeny from such seeds, and seeds arising from the second and subsequent generation plants derived from such a transgenic plant.

The invention also discloses and claims host cells, both native, and genetically engineered, which express the novel cry3Bb* genes to produce Cry3Bb* polypeptides. Preferred examples of bacterial host cells include B. thuringiensis EG11221, EG11222, EG11223, EG11224, EG11225, EG11226, EG11227, EG11228, EG11229, EG11230, EG11231, EG11232, EG11233, EG11234, EG11235, EG11236, EG11237, EG11238, EG11239, EG11241, EG11242, EG11032, EG11035, EG11036, EG11046, EG11048, EG11051, EG11057, EG11058, EG11081, EG11082, EG11083, EG11084, EG11095, and EG11098.

Methods of using such cells to produce Cry3* crystal proteins are also disclosed. Such methods generally involve culturing the host cell (such as B. thuringiensis EG11221, EG11222, EG11223, EG11224, EG11225, EG11226, EG11227, EG11228, EG11229, EG11230, EG11231, EG11232, EG11233, EG11234, EG11235, EG11236, EG11237, EG11238, EG11239, EG11241, EG11242, EG11032, EG11035, EG11036, EG11046, EG11048, EG11051, EG11057, EG11058, EG11081, EG11082, EG11083, EG11084, or EG11095, or EG11098) under conditions effective to produce a Cry3* crystal protein, and obtaining the Cry3* crystal protein from said cell.

In yet another aspect, the present invention provides methods for producing a transgenic plant which expresses a nucleic acid segment encoding the novel recombinant crystal proteins of the present invention. The process of producing transgenic plants is well-known in the art. In general, the method comprises transforming a suitable host cell with one or more DNA segments which contain one or more promoters operatively linked to a coding region that encodes one or more of the disclosed B. thuringiensis crystal proteins. Such a coding region is generally operatively linked to a transcription-terminating region, whereby the promoter is capable of driving the transcription of the coding region in the cell, and hence providing the cell the ability to produce the recombinant protein in vivo. Alternatively, in instances where it is desirable to control, regulate, or decrease the amount of a particular recombinant crystal protein expressed in a particular transgenic cell, the invention also provides for the expression of crystal protein antisense mRNA. The use of antisense mRNA as a means of controlling or decreasing the amount of a given protein of interest in a cell is well-known in the art.

Another aspect of the invention comprises a transgenic plant which express a gene or gene segment encoding one or more of the novel polypeptide compositions disclosed herein. As used herein, the term "transgenic plant" is intended to refer to a plant that has incorporated DNA sequences, including but not limited to genes which are perhaps not normally present, DNA sequences not normally transcribed into RNA or translated into a protein ("expressed"), or any other genes or DNA sequences which one desires to introduce into the non-transformed plant, such as genes which may normally be present in the non-transformed plant but which one desires to either genetically engineer or to have altered expression.

It is contemplated that in some instances the genome of a transgenic plant of the present invention will have been augmented through the stable introduction of one or more Cry3Bb*-encoding transgenes, either native, synthetically modified, or mutated. In some instances, more than one transgene will be incorporated into the genome of the transformed host plant cell. Such is the case when more than one crystal protein-encoding DNA segment is incorporated into the genome of such a plant. In certain situations, it may be desirable to have one, two, three, four, or even more B. thuringiensis crystal proteins (either native or recombinantly-engineered) incorporated and stably expressed in the transformed transgenic plant.

A preferred gene which may be introduced includes, for example, a crystal protein-encoding a DNA sequence from bacterial origin, and particularly one or more of those described herein which are obtained from Bacillus spp. Highly preferred nucleic acid sequences are those obtained from B. thuringiensis, or any of those sequences which have been genetically engineered to decrease or increase the insecticidal activity of the crystal protein in such a transformed host cell.

Means for transforming a plant cell and the preparation of a transgenic cell line are well-known in the art, and are discussed herein. Vectors, plasmids, cosmids, YACs (yeast artificial chromosomes) and DNA segments for use in transforming such cells will, of course, generally comprise either the operons, genes, or gene-derived sequences of the present invention, either native, or synthetically-derived, and particularly those encoding the disclosed crystal proteins. These DNA constructs can further include structures such as promoters, enhancers, polylinkers, or even gene sequences which have positively- or negatively-regulating activity upon the particular genes of interest as desired. The DNA segment or gene may encode either a native or modified crystal protein, which will be expressed in the resultant recombinant cells, and/or which will impart an improved phenotype to the regenerated plant.

Such transgenic plants may be desirable for increasing the insecticidal resistance of a monocotyledonous or dicotyledonous plant, by incorporating into such a plant, a transgenic DNA segment encoding a Cry3Bb* crystal protein which is toxic to coleopteran insects. Particularly preferred plants include grains such as corn, wheat, rye, rice, barley, and oats; legumes such as soybeans; tubers such as potatoes; fiber crops such as flax and cotton; turf and pasture grasses; ornamental plants; shrubs; trees; vegetables, berries, citrus, fruits, cacti, succulents, and other commercially-important crops including garden and houseplants.

In a related aspect, the present invention also encompasses a seed produced by the transformed plant, a progeny from such seed, and a seed produced by the progeny of the original transgenic plant, produced in accordance with the above process. Such progeny and seeds will have one or more crystal protein transgene(s) stably incorporated into its genome, and such progeny plants will inherit the traits afforded by the introduction of a stable transgene in Mendelian fashion. All such transgenic plants having incorporated into their genome transgenic DNA segments encoding one or more Cry3Bb* crystal proteins or polypeptides are aspects of this invention. Particularly preferred transgenes for the practice of the invention include nucleic acid segments comprising one or more cry3Bb* gene(s).

2.7 Biological Functional Equivalents

Modification and changes may be made in the structure of the peptides of the present invention and DNA segments which encode them and still obtain a functional molecule that encodes a protein or peptide with desirable characteristics. The following is a discussion based upon changing the amino acids of a protein to create an equivalent, or even an improved, second-generation molecule. In particular embodiments of the invention, mutated crystal proteins are contemplated to be useful for increasing the insecticidal activity of the protein, and consequently increasing the insecticidal activity and/or expression of the recombinant transgene in a plant cell. The amino acid changes may be achieved by changing the codons of the DNA sequence, according to the codons given in Table 4.

                  TABLE 4                                                          ______________________________________                                         Amino Acids   Codons                                                           ______________________________________                                         Alanine  Ala    A     GCA  GCC  GCG  GCU                                       Cysteine Cys    C     UGC  UGU                                                 Aspartic Acid                                                                           Asp    D     GAC  GAU                                                 Glutamic Acid                                                                           Glu    E     GAA  GAG                                                 Phenylalanine                                                                           Phe    F     UUC  UUU                                                 Glycine  Gly    G     GGA  GGC  GGG  GGU                                       Histidine                                                                               His    H     CAC  CAU                                                 Isoleucine                                                                              Ile    I     AUA  AUC  AUU                                            Lysine   Lys    K     AAA  AAG                                                 Leucine  Leu    L     UUA  UUG  CUA  CUC  CUG  CUU                             Methionine                                                                              Met    M     AUG                                                      Asparagine                                                                              Asn    N     AAC  AAU                                                 Proline  Pro    P     CCA  CCC  CCG  CCU                                       Glutamine                                                                               Gln    Q     CAA  CAG                                                 Arginine Arg    R     AGA  AGG  CGA  CGC  CGG  CGU                             Serine   Ser    S     AGC  AGU  UCA  UCC  UCG  UCU                             Threonine                                                                               Thr    T     ACA  ACC  ACG  ACU                                       Valine   Val    V     GUA  GUC  GUG  GUU                                       Tryptophan                                                                              Trp    W     UGG                                                      Tyrosine Tyr    Y     UAC  UAU                                                 ______________________________________                                    

For example, certain amino acids may be substituted for other amino acids in a protein structure without appreciable loss of interactive binding capacity with structures such as, for example, antigen-binding regions of antibodies or binding sites on substrate molecules. Since it is the interactive capacity and nature of a protein that defines that protein's biological functional activity, certain amino acid sequence substitutions can be made in a protein sequence, and, of course, its underlying DNA coding sequence, and nevertheless obtain a protein with like properties. It is thus contemplated by the inventors that various changes may be made in the peptide sequences of the disclosed compositions, or corresponding DNA sequences which encode said peptides without appreciable loss of their biological utility or activity.

In making such changes, the hydropathic index of amino acids may be considered. The importance of the hydropathic amino acid index in conferring interactive biologic function on a protein is generally understood in the art (Kyte and Doolittle, 1982, incorporate herein by reference). It is accepted that the relative hydropathic character of the amino acid contributes to the secondary structure of the resultant protein, which in turn defines the interaction of the protein with other molecules, for example, enzymes, substrates, receptors, DNA, antibodies, antigens, and the like.

Each amino acid has been assigned a hyldropathic index on the basis of their hydrophobicity and charge characteristics (Kyte and Doolittle, 1982), these are: isoleucine (+4.5); valine (+4.2); leucine (+3.8); phenylalanine (+2.8); cysteine/cystine (+2.5); methionine (+1.9); alanine (+1.8); glycine (-0.4); threonine (-0.7); serine (-0.8); tryptophan (-0.9); tyrosine (-1.3); proline (-1.6); histidine (-3.2); glutamate (-3.5); glutamine (-3.5); aspartate (-3.5); asparagine (-3.5); lysine (-3.9); and arginine (-4.5).

It is known in the art that certain amino acids may be substituted by other amino acids having a similar hydropathic index or score and still result in a protein with similar biological activity, i.e., still obtain a biological functionally equivalent protein. In making such changes, the substitution of amino acids whose hydropathic indices are within ±2 is preferred, those which are within ±1 are particularly preferred, and those within ±0.5 are even more particularly preferred.

It is also understood in the art that the substitution of like amino acids can be made effectively on the basis of hydrophilicity. U.S. Pat. No. 4,554,101, specifically incorporated herein by reference, states that the greatest local average hydrophilicity of a protein, as governed by the hydrophilicity of its adjacent amino acids, correlates with a biological property of the protein.

As detailed in U.S. Pat. No. 4,554,101, the following hydrophilicity values have been assigned to amino acid residues: arginine (+3.0); lysine (+3.0); aspartate (+3.0±1); glutamate (+3.0±1); serine (+0.3); asparagine (+0.2); glutamine (+0.2); glycine (0); threonine (-0.4); proline (-0.5±1); alanine (-0.5); histidine (-0.5); cysteine (-1.0); methionine (-1.3); valine (-1.5); leucine (-1.8); isoleucine (-1.8); tyrosine (-2.3); phenylalanine (-2.5); tryptophan (-3.4).

It is understood that an amino acid can be substituted for another having a similar hydrophilicity value and still obtain a biologically equivalent, and in particular, an immunologically equivalent protein. In such changes, the substitution of amino acids whose hydrophilicity values are within ±2 is preferred, those which are within +1 are particularly preferred, and those within ±0.5 are even more particularly preferred.

As outlined above, amino acid substitutions are generally therefore based on the relative similarity of the amino acid side-chain substituents, for example, their hydrophobicity, hydrophilicity, charge, size, and the like. Exemplary substitutions which take various of the foregoing characteristics into consideration are well known to those of skill in the art and include: arginine and lysine; glutamate and aspartate; serine and threonine; glutamine and asparagine; and valine, leucine and isoleucine.

3.0 BRIEF DESCRIPTION OF THE DRAWINGS

The drawings form part of the present specification and are included to further demonstrate certain aspects of the present invention. The invention may be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.

FIG. 1. Schematic representation of the monomeric structure of Cry3Bb.

FIG. 2. Stereoscopic view of the monomeric structure of Cry3Bb with associated water molecules (represented by dots).

FIG. 3A. Schematic representation of domain 1 of Cry3Bb

FIG. 3B. Diagram of the positions of the 7 helices that comprise domain 1.

FIG. 4. Domain 1 of Cry3Bb is organized into seven α helices illustrated in FIG. 3A (schematic representation) and FIG. 3B (schematic diagram). The α helices and amino acids residues are shown.

FIG. 5A. Schematic representation of domain 2 of Cry3Bb.

FIG. 5B. Diagram of the positions of the 11 β stands that compose the 3 βsheets of domain 2.

FIG. 6. Domain 2 of Cry3Bb is a collection of three anti-parallel β sheets illustrated in FIG. 5. The amino acids that define these sheets is listed below (α8, amino aids 322-328, also is included in domain 2):

FIG. 7A. Schematic representation of domain 3 of Cry3Bb.

FIG. 7B. Diagram of the positions of the β strands that comprise domain 3.

FIG. 8. Domain 3 (FIG. 7) is a loosely organized collection of β strands and loops; no β sheets are present. The β stands contain the amino acids limited below:

FIG. 9A. A "side" view of the dimeric structure of Cry3Bb. The helical bundles of domains 1 can be seem in the middle of the molecule.

FIG. 9B. A "top" view of the dimeric stricture of Cry3Bb. The helical bundles of domains 1 can be seem in the middle of the molecule.

FIG. 10. A graphic representation of the growth in conductance with time of channels formed by Cry3A and Cry3Bb in planar lipid bilayers. Cry3A forms channels with higher conductances much more rapidly than Cry3Bb.

FIG. 11. A map of pEG1701 which contains the Cry3Bb gene with the cry1F terminator.

FIG. 12. The results of replicated 1-dose assays against SCRW larvae of Cry3Bb proteins altered in the 1B2,3 region.

FIG. 13. The results of replicated, 1-dose assays against SCRW larvae of Cry3Bb proteins altered in the 1B6, 7 region.

FIG. 14. The results of replicated, 1-dose screens against SCRW larvae of Cry3Bb proteins altered in the 1B10,11 region.

FIG. 15. Single channel recordings of channels formed by Cry3Bb.11230 and WT Cry3Bb in planar lipid bilayers. Cry3Bb.11230 forms channels with well resolved open and closed states while Cry3Bb rarely does.

FIG. 16. Single channel recordings of channels formed by Cry3Bb and Cry3Bb.60, a truzncated form of Cry3Bb. Cry3Bb.60 forms channels more quickly than Cry3Bb and, unlike Cry3Bb, produces channels with well resolved open and closed states.

FIG. 17A. Sequence alignment of the amino acid sequence of Cry3C (SEQ ID NO:109), Cry3Bb2 (SEQ ID NO:110), Cry3Bb (SEQ ID NO:111), Cry3Ba (SEQ ID NO:112), and Cry3A (SEQ ID NO:113).

FIG. 17B. Shown is a continuation of alignment of the amino acid sequence of Cry3C (SEQ ID NO:109), Cry3Bb2 (SEQ ID NO:110), Cry3Bb (SEQ ID NO:111), Cry3Ba (SEQ ID NO:112), and Cry3A (SEQ ID NO:113) shown in FIG. 17A.

FIG. 17C. Shown is a continuation of alignment of the amino acid sequence of Cry3C (SEQ ID NO:109), Cry3Bb2 (SEQ ID NO:110), Cry3Bb (SEQ ID NO:111), Cry3Ba (SEQ ID NO:112), and Cry3A (SEQ ID NO:113) shown in FIG. 17A.

4.0 DESCRIPTION OF ILLUSTRATIVE EMBODIMENTS

The invention defines new B. thuringiensis (Bt) insecticidal δ-endotoxin proteins and the biochemical and biophysical strategies used to design the new proteins. Delta-endodtoxins are a class of insecticdal proteins produced by B. thuringiensis that form cation-selective channels in planar lipid bilayers (English and Slatin, 1992). The new δ-endotoxins are based on the parent structure of the coleopteran-active, δ-endotoxin Cry3Bb. Like other members of the coleopteran-active class of δ-endotoxins, including Cry3A and Cry3B, Cry3Bb exhibits excellent insecticidal activity against the Colorado Potato Beetle (Leptinotarsa decemlineata). However, unlike Cry3A and Cry3B, Cry3Bb is also active against the southern corn rootworm or SCRW (Diabriotica undecimpunctata howardi Barber) and the western corn rootworm or WCRW (Diabrotica virgifera virgifera LeConte). The new insecticidal proteins described herein were specifically designed to improve the biological activity of the parent Cry3Bb protein. In addition, the design strategies themselves are novel inventions capable of being applied to and improving B. thuringiensis δ-endotoxins in general. B. thuringiensis δ-endotoxins are also members of a larger class of bacterial toxins that form ion channels (see English and Slatin 1992, for a review). The inventors, therefore, believe that these design strategies can also be applied to any biologically active, channel-forming protein to improve its biological properties.

The designed Cry3Bb proteins were engineered using one or more of the following strategies including (1) identification and alteration of protease-sensitive sites and proteolytic processing; (2) analysis and manipulation of bound water; (3) manipulation of hydrogen bonds around mobile regions; (4) loop analysis and loop redesign around flexible helices; (5) loop design around β strands and β sheets; (6) identification and redesign of complex electrostatic surfaces; (7) identification and removal of metal binding sites; (8) alteration of quaternary structure; (9) identification and design of structural residues; and (10) combinations of any and all sites defined by strategies 1-9. These design strategies permit the identification and redesign of specific sites on Cry3Bb, ultimately creating new proteins with improved insecticidal activities. These new proteins are designated Cry3Bb designed proteins and are named Cry3Bb followed by a period and a suffix (e.g, Cry3Bb.60, Cry3Bb.11231). The new proteins are listed in Table 2 along with the specific sites on the molecule that were modified, the amino-acid sequence changes at those sites that improve biological activity, the improved insecticidal activities and the design method used to identify that specific site.

4.1 Some Advantages of the Invention

Mutagenesis studies with cry genes have failed to identify a significant number of mutant crystal proteins which have improved broad-spectrum insecticidal activity, that is, with improved toxicity towards a range of insect pest species. Since agricultural crops are typically threatened by more than one insect pest species at any given time, desirable mutant crystal proteins are preferably those that exhibit improvements in toxicity towards multiple insect pest species. Previous failures to identify such mutants may be attributed to the choice of sites targeted for mutagenesis. For example, with respect to the related protein, Cry1C, sites within domain 2 and domain 3 have been the principal targets of mutagenesis efforts, primarily because these domains are believed to be important for receptor binding and in determining insecticidal specificity (Aronson et al., 1995; Chen et al. 1993; de Maagd et al., 1996; Lee et al., 1992; Lee et al., 1995; Lu et al., 1994; Smedley and Ellar, 1996; Smith and Ellar, 1994; Rajamohan et al., 1995; Rajamohan et al., 1996) In contrast, the present inventors reasoned that the toxicity of Cry3 proteins, and specifically the toxicity of the Cry3Bb protein, may be improved against a broader array of target pests by targeting regions involved in ion channel function rather than regions of the molecule directly involved in receptor interactions, namely domains 2 and 3. Accordingly, the inventors opted to target regions within domain 1 cf Cry3Bb for mutagenesis for the purpose of isolating Cry3Bb mutants with improved broad spectrum toxicity. Indeed, in the present sent invention, Cry3Bb mutants are described that show improved toxicity towards several coleopteran pests.

At least one, and probably more than one, α helix of domain 1 is involved in the formation of ion channels and pores within the insect midgut epithelium (Gazit and Shai, 1993; Gazit and Shai, 1995). Rather than target for mutagenesis the sequences encoding the α helices of domain 1 as others have (Wu and Aronson, 1992; Aronson et al., 1995; Chen et al., 1995), the present inventors opted to target exclusively sequences encoding amino acid residues adjacent to or lying within the predicted loop regions of Cry3Bb that separate these α helices. Amino acid residues within these loop regions or amino acid residues capping the end of an α helix and lying adjacent to these loop regions may affect the spatial relationships among these α helices. Consequently, the substitution of these amino acid residues may result in subtle changes in tertiary structure, or even quaternary structure, that positively impact the function of the ion channel. Amino acid residues in the loop regions of domain 1 are exposed to the solvent and thus are available for various molecular interactions. Altering these amino acids could result in greater stability of the protein by eliminating or occluding protease-sensitive sites. Amino acid substitutions that change the surface charge of domain 1 could alter ion channel efficiency or alter interactions with the brush border membrane or with other portions of the toxin molecule allowing binding or insertion to be more effective.

According to this invention, base substitutions are made in the underlying cry3Bb nucleic acid residues in order to change particular codons of the corresponding polypeptides, and particularly, in those loop regions between α-helices. The insecticidal activity of a crystal protein ultimately dictates the level of crystal protein required for effective insect control. The potency of an insecticidal protein should be maximized as much as possible in order to provide for its economic and efficient utilization in the field. The increased potency of an insecticidal protein in a bioinsecticide formulation would be expected to improve the field performance of the bioinsecticide product. Alternatively, increased potency of an insecticidal protein in a bioinsecticide formulation may promote use of reduced amounts of bioinsecticide per unit area of treated crop, thereby allowing for more cost-effective use of the bioinsecticide product. When expressed in planta, the production of crystal proteins with improved insecticidal activity can be expected to improve plant resistance to susceptible insect pests.

4.2 Methods for Culturing B. thuringiensis to Produce Crystal Proteins

The B. thuringiensis strains described herein may be cultured using standard known media and fermentation techniques. Upon completion of the fermentation cycle, the bacteria may be harvested by first separating the B. thuringiensis spores and crystals from the fermentation broth by means well known in the art. The recovered B. thuringiensis spores and crystals can be formulated into a wettable powder, a liquid concentrate, granules or other formulations by the addition of surfactants, dispersants, inert carriers and other components to facilitate handling and application for particular target pests. The formulation and applition procedures are all well known in the art.

4.3 Recombinant Host Cells for Expression of Cry* Genes

The nucleotide sequences of the subject invention can be introduced into a wide variety of microbial hosts. Expression of the toxin gene results, directly or indirectly, in the intracellular production and maintenance of the pesticide. With suitable hosts, e.g., Pseudomonas, the microbes can be applied to the sites of coleopteran insects where they will proliferate and be ingested by the insects. The result is a control of the unwanted insects. Alternatively, the microbe hosting the toxin gene can be treated under conditions that prolong the activity of the toxin produced in the cell. The treated cell then can be applied to the environment of target pest(s). The resulting product retains the toxicity of the B. thuringiensis toxin.

Suitable host cells, where the pesticide-containing cells will be treated to prolong the activity of the toxin in the cell when the then treated cell is applied to the environment of target pest(s), may include either prokaryotes or eukaryotes, normally being limited to those cells which do not produce substances toxic to higher organisms, such as mammals. However, organisms which produce substances toxic to higher organisms could be used, where the toxin is unstable or the level of application sufficiently low as to avoid any possibility or toxicity to a mammalian host. As hosts, of particular interest will be the prokaryotes and the lower eukaryotes, such as fungi. Illustrative prokaryotes, both Gram-negative and Gram-positive, include Enterobacteriaceae, such as Escherichia, Erwinia, Shigella, Salmonella, and Proteus; Bacillaceae; Rhizobiceae, such as Rhizobium, Spirillaceae, such as photobacterium, Zymomonas, Serratia, Aeromonas, Vibrio, Desulfovibrio, Spirillum, Lactobacillaceae; Pseudomonadaceae, such as Pseudomonas and Acetobacter, Azotobacteraceae, Actinomycetales, and Nitrobacteraceae. Among eukaryotes are fungi, such as Phycomycetes and Ascomycetes, which includes yeast, such as Saccaromyces and Schizosaccharomyces; and Basidiomycetes yeast, such as Rhodlotorula, Aureobasidium, Sporobolomyces, and the like.

Characteristics of particular interest in selecting a host cell for purposes of production include ease of introducing the B. thuringiensis gene into the host, availability of expression systems, efficiency of expression, stability of the pesticide in the host, and the presence of auxiliary genetic capabilities. Characteristics of interest for use as a pesticide microcapsule include protective qualities for the pesticide, such as thick cell walls, pigmentation, and intracellular packaging or formation of inclusion bodies; leaf affinity; lack of mammalian toxicity; attractiveness to pests for ingestion; ease of killing and fixing without damage to the toxin; and the like. Other considerations include ease of formulation and handling, economics, storage stability, and the like.

Host organisms of particular interest include yeast, such as Rhodotorula sp., Aureobasidium sp., Saccharomyces sp., and Sporolbolomyces sp., phylloplane organisms such as Pseudomonas sp., Erwinia sp. and Flavobacterium sp.; or such other organisms as Escherichia, Lactobacillus sp., Bacillus sp., Streptoinivces sp., and the like. Specific organisms include Pseudomonas aeruginosa, Pseudomonas fluorescens, Saccharomyces cerevisiae; B. thuringiensis, Escherichia coli, B. subtilis, B. megaterium, B. cereus, Streptomyces lividans and the like.

Treatment of the microbial cell, e.g., a microbe containing the B. thuringiensis toxin gene, can be by chemical or physical means, or by a combination of chemical and/or physical means, so long as the technique does not deleteriously affect the properties of the toxin, nor diminish the cellular capability in protecting the toxin. Examples of chemical reagents are halogenating agents, particularly halogens of atomic no. 17-80. More particularly, iodine can be used under mild conditions and for sufficient time to achieve the desired results. Other suitable techniques include treatment with aldehydes, such as formaldehyde and glutaraldehye; anti-infectives, such as zephiran chloride and cetylpyridinium chloride; alcohols, such as isopropyl and ethanol; various histologic fixatives, such as Lugol's iodine, Bouin's fixative, and Helly's fixatives, (see e.g., Humason, 1967); or a combination of physical (heat) and chemical agents that preserve and prolong the activity of the toxin produced in the cell when the cell is administered to the host animal. Examples of physical means are short wavelength radiation such as γ-radiation and X-radiation, freezing, UV irradiation, lyophilization, and the like. The cells employed will usually be intact and be substantially in the proliferative form when treated, rather than in a spore form, although in some instances pores may be employed.

Where the B. thuringiensis toxin gene is introduced via a suitable vector into a microbial host, and said host is applied to the environment in a living state, it is essential that certain host microbes be used. Microorganism hosts are selected which are known to occupy the "phytosphere" (phylloplane, phyllosphere, rhizosphere, and/or rhizoplane) of one or more crops of interest. These microorganisms are selected so as to be capable of successfully competing in the particular environment (crop and other insect habitats) with the wild-type microorganisms, provide for stable maintenance and expression of the gene expressing the polypeptide pesticide, and, desirably, provide for improved protection of the pesticide from environmental degradation and inactivation.

A large number of microorganisms are known to inhabit the phylloplane (the surface of the plant leaves) and/or the rhizosphere (the soil surrounding plant roots) of a wide variety of important crops. These microorganisms include bacteria, algae, and fungi. Of particular interest are microorganisms, such as bacteria, e.g., genera Bacillus (including the species and subspecies B. thuringiensis kurstaki HD-1, B. thuringiensis kurstaki HD-73, B. thuringiensis sotto, B. thuringiensis berliner, B. thuringiensis thuringiensis, B. thuringiensis tolworthi, B. thuringiensis dendrolimus, B. thuringiensis alesti, B. thuringiensis galleriae, B. thuringiensis aizawai, B. thuringiensis subtoxicus, B. thuringiensis entomocidus, B. thuringiensis jenebrionis and B. thuringiensis san diego); Pseudomonas, Erwinia, Serratia, Klebsiella, Zanthomonas, Streptomyces, Rhizobium, Rhodopseudomonas, Methylophilius, Agrobacterium, Acetobacter, Lactobacillus, Arthrobacter, Azotobacter, Leuconostoc, and Alcaligenes; fungi, particularly yeast, e.g., genera Saccharomyces, Cryptococcus, Kluyveromyces, Sporobolomyces, Rhodotorula, and Aureobasidium. Of particular interest are such phytosphere bacterial species as Pseudomonas syringae, Pseudomonas fluorescens, Serratia marcescens, Acetobacter xylinum, Agrobacterium tumefaciens, Rhodobacter sphaeroides, Xanthomonas campestris, Rhizobium melioti, Alcaligenes eutrophus, and Azotobacter vinlandii; and phytosphere yeast species such as Rhodotorula rubra, R. glutinis, R. marina, R. aurantiaca, Cryptococcus albidus, C. diffluens, C. laurentii, Saccharomyces rosei, S. pretoriensis, S. cerevisiae, Sporobolomyces roseus, S. odorus, Kluyveromyces veronae, and Aureobasidium pollulans.

4.4 Definitions

In accordance with the present invention, nucleic acid sequences include and are not limited to DNA (including and not limited to genomic or extragenomic DNA), genes, RNA (including and not limited to mRNA and tRNA), nucleosides, and suitable nucleic acid segments either obtained from native sources, chemically synthesized, modified, or otherwise prepared by the hand of man. The following words and phrases have the meanings set forth below.

A, an: In accordance with long standing patent law convention, the words "a" and "an" when used in this application, including the claims, denotes "one or more".

Broad-spectrum: Refers to a wide range of insect species.

Broad-spectrum activity: The toxicity towards a wide range of insect species.

Expression: The combination of intracellular processes, including transcription and translation undergone by a coding DNA molecule such as a structural gene to produce a polypeptide.

Insecticidal activity: The toxicity towards insects.

Insecticidal specificity: The toxicity exhibited by a crystal protein or proteins, microbe or plant, towards multiple insect species.

Intraorder specificity: The toxicity of a particular crystal protein towards insect species within an Order of insects (e.g., Order Coleoptera).

Interorder specificity: The toxicity of a particular crystal protein towards insect species of different Orders (e.g., Orders Coleoptera and Diptera).

LC₅₀ : The lethal concentration of crystal protein that causes 50% mortality of the insects treated.

LC₉₅ : The lethal concentration of crystal protein that causes 95% mortality of the insects treated.

Promoter: A recognition site on a DNA sequence or group of DNA sequences that provide an expression control element for a structural gene and to which RNA polymerase specifically binds and initiates RNA synthesis (transcription) of that gene.

Regeneration: The process of growing a plant from a plant cell (e.g., plant protoplast or explant).

Structural gene: A gene that is expressed to produce a polypeptide.

Transformation: A process of introducing an exogenous DNA sequence (e.g., a vector, a recombinant DNA molecule) into a cell or protoplast in which that exogenous DNA is incorporated into a chromosome or is capable of autonomous replication.

Transformed cell: A cell whose DNA has been altered by the introduction of an exogenous DNA molecule into that cell.

Transgenic cell: Any cell derived or regenerated from a transformed cell or derived from a transgenic cell. Exemplary transgenic cells include plant calli derived from a transformed plant cell and particular cells such as leaf, root, stem, e.g., somatic cells, or reproductive (germ) cells obtained from a transgenic plant.

Transgenic plant: A plant or progeny thereof derived from a transformed plant cell or protoplast, wherein the plant DNA contain, an introduced exogenous DNA molecule not originally present in a native, non-transgenic plant of the same strain. The terms "transgenic plant" and "transformed plant" have sometimes been used in the art as synonymous terms to define a plant whose DNA contains an exogenous DNA molecule. However, it is thought more scientifically correct to refer to a regenerated plant or callus obtained from a transformed plant cell or protoplast as being a transgenic plant, and that usage will be followed herein.

Vector: A DNA molecule capable of replication in a host cell and/or to which another DNA segment can be operatively linked so as to bring about replication of the attached segment. A plasmid is an exemplary vector.

As used herein, the designations "CryIII" and "Cry3" are synonymous, as are the designations "CryIIIB2" and "Cry3Bb." Likewise, the inventors have utilized the generic term Cry3Bb* to denote any and all Cry3Bb variants which comprise amino acid sequences modified in the protein. Similarly, cry3Bb* is mean to denote any and all nucleic acid segments and/or genes which encode a Cry3Bb* protein, etc.

4.5 Preparations of Cry3* Polynucleotides

Once the structure of the desired peptide to be mutagenized has been analyzed using one or more of the design strategies disclosed herein, it will be desirable to introduce one or more mutations into either the protein or, alternatively, into the DNA sequence encoding the protein for the purpose of producing a mutated protein with altered bioinsecticidal properties.

To that end, the present invention encompasses both site-specific mutagenesis methods and random mutagenesis of a nucleic acid segment encoding a crystal protein in the manner described herein. In particular, methods are disclosed for the mutagenesis of nucleic acid segments encoding the amino acid sequences using one or more of the design strategies described herein. Using the assay methods described herein, one may then identify mutants arising from these procedures which have improved insecticidal properties or altered specificity, either intraorder or interorder.

The means for mutagenizing a DNA segment encoding a crystal protein are well-known to those of skill in the art. Modifications may be made by random, or site-specific mutagenesis procedures. The nucleic acid may be modified by altering its structure through the addition or deletion of one or more nucleotides from the sequence.

Mutagenesis may be performed in accordance with any of the techniques known in the art such as and not limited to synthesizing an oligonucleotide having one or more mutations within the sequence of a particular crystal protein. A "suitable host" is any host which will express Cry3Bb, such as and not limited to B. thuringiensis and E. coli. Screening for insecticidal activity, in the case of Cry3Bb includes and is not limited to coleopteran-toxic activity which may be screened four by techniques known in the art.

In particular, site-specific mutagenesis is a technique useful in the preparation of individual peptides, or biologically functional equivalent proteins or peptides, through specific mutagenesis of the underlying DNA. The technique further provides a ready ability to prepare and test sequence variants, for example, incorporating one or more of the foregoing considerations, by introducing one or more nucleotide sequence changes into the DNA. Site-specific mutagenesis allows the production of mutants through the use of specific oligonucleotide sequences which encode the DNA sequence of the desired mutation, as well as a sufficient number of adjacent nucleotides, to provide a primer sequence of sufficient size and sequence complexity to form a stable duplex on both sides of the deletion junction being traversed. Typically, a primer of about 17 to about 75 nucleotides or more in length is preferred, with about 10 to about 25 or more residues on both sides of the junction of the sequence being altered.

In general, the technique of site-specific mutagenesis is well known in the art, as exemplified by various publications. As will be appreciated, the technique typically employs a phage vector which exists in both a single stranded and double stranded form. Typical vectors useful in site-directed mutagenesis include vectors such as the M13 phage. These phage are readily commercially available and their use is generally well known to those skilled in the art. Double stranded plasmids art also routinely employed in site directed mutagenesis which eliminates the step of transferring the gene of interest from a plasmid to a phage.

In general, site-directed mutagenesis in accordance herewith is performed by first obtaining a single-stranded vector or melting apart of two strands of a double stranded vector which includes within its sequence a DNA sequence which encodes the desired peptide. An oligonucleotide primer bearing the desired mutated sequence is prepared, generally synthetically. This primer is then annealed with the single-stranded vector, and subjected to DNA polymerizing enzymes such as E. coli polymerase I Klenow fragment, in order to complete the synthesis of the mutation-bearing strand. This, a heteroduplex is formed wherein one strand encodes the original non-mutated sequence and the second strand bears the desired mutation. This heteroduplex vector is then used to transform or transfect appropriate cells, such as E. coli cells. and clones are selected which include recombinant vectors bearing the mutated sequence arrangement. A genetic selection scheme was devised by Kunkel et al. (1987) to enrich for clones incorporating the mutagenic oligonucleotide. Alternatively, the use of PCR™ with commercially available thermostable enzymes such as Taq polymerase may be used to incorporate a mutagenic oligonucleotide primer into an amplified DNA fragment that can then be cloned into an appropriate cloning or expression vector. The PCR™-mediated mutagenesis procedures of Tomic et al. (1990) and Upender et al. (1995) provide two examples of such protocols. A PCR™ employing a thermostable ligase in addition to a thermostable polymerase may also be used to incorporate a phosphorylated mutagenic oilgonucleotide into an amplified DNA fragment that may then be cloned into an appropriate cloning or expression vector. The mutagenesis procedure described by Michael (1994) provides an example of one such protocol.

The preparation of sequence variants of the selected peptide-encoding DNA segments using site-directed mutagenesis is provided as a means of producing potentially useful species and is not meant to be limiting as there are other ways in which sequence variants of peptides and the DNA sequences encoding them may be obtained. For example, recombinant vectors encoding the desired peptide sequence may be treated with mutagenic agents, such as hydroxylamine, to obtain sequence variants.

As used herein, the term "oligonucleotide directed mutagenesis procedure" refers to template-dependent processes and vector-mediated propagation which result in an increase in the concentration of a specific nucleic acid molecule relative to its initial concentration, or in an increase in the concentration of a detectable signal, such as amplification. As used herein, the term "oligonucleotide directed mutagenesis procedure" is intended to refer to a process that involves the template-dependent extension of a primer molecule. The term template dependent process refers to nucleic acid synthesis of an RNA or a DNA molecule wherein the sequence of the newly synthesized strand of nucleic acid is dictated by the well-known rules of complementary base pairing (see, for example, Watson, 1987). Typically, vector mediated methodologies involve the introduction of the nucleic acid fragment into a DNA or RNA vector, the clonal amplification of the vector, and the recovery of the amplified nucleic acid fragment. Examples of such methodologies are provided by U. S. Pat. No. 4,237,224, specifically incorporated herein by reference in its entirety.

A number of template dependent processes are available to amplify the target sequences of interest present in a sample. One of the best known amplification methods is the polymerase chain reaction (PCR™) which is described in detail in U.S. Pat. Nos. 4,683,195, 4,683,202 and 4,800,159 (each of which is specifically incorporated herein by reference in its entirety). Briefly, in PCR™, two primer sequences are prepared which are complementary to regions on opposite complementary strands of the target sequence. An excess of deoxynucleoside triphosphates are added to a reaction mixture along with a DNA polymerase (e.g., Taq polymerase). If the target sequence is present in a sample, the primers will bind to the target and the polymerase will cause the primers to be extended along the target sequence by adding on nucleotides. By raising and lowering the temperature of the reaction mixture, the extended primers will dissociate from the target to form reaction products, excess primers will bind to the target and to the reaction products and the process is repeated. Preferably a reverse transcriptase PCR™ amplification procedure may be performed in order to quantify the amount of mRNA amplified. Polymerase chain reaction methodologies are well known in the art.

Another method for amplification is the ligase chain reaction (referred to as LCR), disclosed in Eur. Pat. Appl. Publ. No. 320,308, incorporated herein by reference in its entirety. In LCR, two complementary probe pairs are prepared, and in the presence of the target sequence, each pair will bind to opposite complementary strands of the target such that they abut. In the presence of a ligase, the two probe pairs will link to form a single unit. By temperature cycling, as in PCR™, bound ligated units dissociate from the target and then serve as "target sequences" for ligation of excess probe pairs. U.S. Pat. No. 4,883,750, specifically incorporated herein by reference in its entirety, describes an alternative method of amplification similar to LCR for binding probe pairs to a target sequence.

Qbeta Replicase™, described in Intl. Pat. Appl. Publ. No. PCT/US87/00880, incorporated herein by reference in its entirety, may also be used as still another amplification method in the present invention. In this method, a replicative sequence of RNA which has a region complementary to that of a target is added to a sample in the presence of an RNA polymerase. The polymerase will copy the replicative sequence which can then be detected.

An isothermal amplification method, in which restriction endonucleases and ligases are used to achieve the amplification of target molecules that contain nucleotide 5'-[α-thio]triphosphates in one strand of a restriction site (Walker et al., 1992, incorporated herein by reference in its entirety), may also be useful in the amplification of nucleic acids in the present invention.

Strand Displacement Amplification (SDA) is another method of carrying out isothermal amplification of nucleic acids which involves multiple rounds of strand displacement and synthesis, i.e., nick translation. A similar method, called Repair Chain Reaction (RCR) is another method of amplification which may be useful in the present invention and is involves annealing several probes throughout a region targeted for amplification, followed by a repair reaction in which only two of the four bases are present. The other two bases can be added as biotinylated derivatives for easy detection. A similar approach is used in SDA

Sequences can also be detected using a cyclic probe reaction (CPR). In CPR, a probe having 3' and 5' end sequences of non-Cry-specific DNA and an internal sequence of a Cry-specific RNA is hybridized to DNA which is present in a sample. Upon hybridization, the reaction is treated with RNaseH, and the products of the probe identified as distinctive products generating a signal which are released after digestion. The original template is annealed to another cycling probe and the reaction is repeated. Thus, CPR involves amplifying a signal generated by hybridization of a probe to a cry-specific expressed nucleic acid.

Still other amplification methods described in Great Britain Pat. Appl. No. 2 202 328, and in Intl. Pat. Appl. Publ. No. PCT/US89/03 025, each of which is incorporated herein by reference in its entirety, may be used in accordance with the present invention. In the former application, "modified" primers are used in a PCR™ like, template and enzyme dependent synthesis. The primers may be modified by labeling with a capture moiety (e.g., biotin) and/or a detector moiety (e.g., enzyme). In the latter application, an excess of labeled probes are added to a sample. In the presence of the target sequence, the probe binds and is cleaved catalytically. After cleavage, the target sequence is released intact to be bound by excess probe. Cleavage of the labeled probe signals the presence of the target sequence.

Other nucleic acid amplification procedures include transcription-based amplification systems (TAS) (Kwoh et al., 1989; Intl. Pat. Appl. Publ. No. WO 88/10315, incorporated herein by reference in its entirety), including nucleic acid sequence based amplification (NASBA) and 3SR. In NASBA, the nucleic acids can be prepared for amplification by standard phenol/chloroform extraction, heat denaturation of a sample, treatment with lysis buffer and minispin columns for isolation of DNA and RNA or guanidinium chloride extraction of RNA. These amplification techniques involve annealing a primer which has crystal protein-specific sequences. Following polymerization, DNA/RNA hybrids are digested with RNase H while double stranded DNA molecules are heat denatured again. In either case the single stranded DNA is made fully double stranded by addition of second crystal protein-specific primer, followed by polymerization. The double stranded DNA molecules are then multiply transcribed by a polymerase such as T7 or SP6. In an isothermal cyclic reaction, the RNAs are reverse transcribed into double stranded DNA, and transcribed once against with a polymerase such as T7 or SP6. The resulting products, whether truncated or complete, indicate crystal protein-specific sequences.

Eur. Pat. Appl. Publ. No. 329,822, incorporated herein by reference in its entirety, disclose a nucleic acid amplification process involving cyclically synthesizing single-stranded RNA ("ssRNA"), ssDNA, and double-stranded DNA (dsDNA), which may be used in accordance with the present invention. The ssRNA is a first template for a first primer oligonucleotide, which is elongated by reverse transcriptase (RNA-dependent DNA polymerase). The RNA is then removed from resulting DNA:RNA duplex by the action of ribonuclease H (RNase H, an RNase specific for RNA in a duplex with either DNA or RNA). The resultant ssDNA is a second template for a second primer, which also includes the sequences of an RNA polymerase promoter (exemplified by T7 RNA polymerase) 5' to its homology to its template. This primer is then extended by DNA polymerase (exemplified by the large "Klenow" fragment of E. coli DNA polymerase I), resulting as a double-stranded DNA ("dsDNA") molecule, having a sequence identical to that of the original RNA between the primers and having additionally, at one end, a promoter sequence. This promoter sequence can be used by the appropriate RNA polymerase to make many RNA copies of the DNA. These copies can then re-enter the cycle leading to very swift amplification. With proper choice of enzymes, this amplification can be done isothermally without addition of enzymes at each cycle. Because of the cyclical nature of this process, the starting sequence can be chosen to be in the form of either DNA or RNA.

Intl. Pat. Appl. Publ. No. WO 89/06700, incorporated herein by reference in its entirety, disclose a nucleic acid sequence amplification scheme based on the hybridization of a promoter/primer sequence to a target single-stranded DNA ("ssDNA") followed by transcription of many RNA copies of the sequence. This scheme is not cyclic; i.e., new templates are not produced from resultant RNA transcripts. Other amplification methods include "RACE" (Frohman, 1990), and "one-sided PCR™" (Ohara, 1989) which are well-known to those of skill in the art.

Methods based on ligation of two (or more) oligonucleotides in the presence of nucleic acid having the sequence of the resulting "di-oligonucleotide", thereby amplifying the di-oligonucleotide (Wu and Dean, 1996, incorporated herein by reference in its entirety), may also be used in the amplification of DNA sequences of the present invention.

4.6 Phage-Resistant Variants

In certain embodiments, one may desired to prepare one or more phage resistant variants of the B. thuringiensis mutants prepared by the methods described herein. To do so, an aliquot of a phage lysate is spread onto nutrient agar and allowed to dry. An aliquot of the phage sensitive bacterial strain is then plated directly over the dried lysate and allowed to dry. The plates are incubated at 30° C. The plates are incubated for 2 days and, at that time, numerous colonies could be seen growing on the agar. Some of these colonies are picked and subcultured onto nutrient agar plates. These apparent resistant cultures are tested for resistance by cross streaking with the phage lysate. A line of the phage lysate is streaked on the plate and allowed to dry. The presumptive resistant cultures are then streaked across the phage line. Resistant bacterial cultures show no lysis anywhere in the streak across the phage line after overnight incubation at 30° C. The resistance to phage is then reconfirmed by plating a lawn of the resistant culture onto a nutrient agar plate. The sensitive strain is also plated in the same manner to serve as the positive control. After drying, a drop of the phage lysate is plated in the center of the plate and allowed to dry. Resistant cultures showed no lysis in the area where the phage lysate has been placed after incubation at 30° C. for 24 hours.

4.7 Crystal Protein Compositions as Insecticides and Methods of Use

Order Coleoptera comprises numerous beetle species including ground beetles, reticulated beetles, skin and larder beetles, long-horned beetles, leaf beetles, weevils, bark beetles, ladybird beetles, soldier beetles, stag beetles, water scavenger beetles, and a host of other beetles. A brief taxonomy of the Order is given at the website http://www.ncbi.nlm.nih.gov/Taxonomy/tax.html.

Particularly important among the Coleoptera are the agricultural pests included within the infraorders Chrysomeliformia and Cucujiformia. Members of the infraorder Chrysomeliformia, including the leaf beetles (Chrysomelidae) and the weevils (Curculionidae), are particularly problematic to agriculture, and are responsible for a variety of insect damage to crops and plants. The infraorder Cucujiformia includes the families Coccinellidae, Cucujidae, Lagridae, Meloidae, Rhipiphoridae, and Tenebrionidae. Within this infraorder, members of the family Chrysomelidae (which includes the genera Exema, Chrysomela, Oreina, Chrysolina, Leptinotarsa, Gonioctena, Oulema, Monozia, Ophraella, Cerotoma, Diabrotica, and Lachnaia), are well-known for their potential to destroy agricultural crops.

As the toxins of the present invention have been shown to be effective in combatting a variety of members of the order Coleoptera, the inventors contemplate that the insects of many Coleopteran genera may be controlled or eradicated using the polypeptide compositions described herein. Likewise, the methods described herein for generating modified polypeptides having enhanced insect specificity may also be useful in extending the range of the insecticidal activity of the modified polypeptides to other insect species within, and outside of, the Order Coleoptera.

As such, the inventors contemplate that the crystal protein compositions disclosed herein will find particular utility as insecticides for topical and/or systemic application to field crops, including but not limited to rice, wheat, alfalfa, corn (maize), soybeans, tobacco, potato, barley, canola (rapeseed), sugarbeet, sugarcane, flax, rye, oats, cotton, sunflower; grasses, such as pasture and turf grasses; fruits, citrus, nuts, trees, shrubs and vegetables; as well as ornamental plants, cacti, succulents, and the like.

Disclosed and claimed is a composition comprising an insecticidally-effective amount of a Cry3Bb* crystal protein composition. The composition preferably comprises the amino acid sequence of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48 SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, or SEQ ID NO:108 or biologically-functional equivalents thereof.

The insecticide composition may also comprise a Cry3Bb* crystal protein that is encoded by a nucleic acid sequence having the sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5. SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13. SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, or SEQ ID NO:108, or, alternatively, a nucleic acid sequence which hybridizes to the nucleic acid sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5. SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13. SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, or SEQ ID NO:107 under conditions of moderate stringency.

The insecticidal compositions may comprise one or more B. thuringiensis cell types, or one or more cultures of such cells, or, alternatively, a mixture of one or more B. thuringiensis cells which express one or more of the novel crystal proteins of the invention in combination with another insecticidal composition. In certain aspects it may be desirable to prepare compositions which contain a plurality of crystal proteins, either native or modified, for treatment of one or more types of susceptible insects. The B. thuringiensis cells of the invention can be treated prior to formulation to prolong the insecticidal activity when the cells are applied to the environment of the target insect(s) Such treatment can be by chemical or physical means, or by a combination of chemical and/or physical means, so long as the technique does not deleteriously affect the properties of the insecticide, nor diminish the cellular capability in protecting the insecticide. Examples of chemical reagents are halogenerating agents, particularly halogens of atomic no. 17-80 More particularly, iodine can be used under mild conditions and for sufficient time to achieve the desired results. Other suitable techniques include treatment with aldehydes, such as formaldehyde and glutaraldehyde; anti-infective, such as zephiran chloride; alcohols, such as isopropyl and ethanol; various histologic fixatives, such as Bouin's fixative and Helly's fixative (see Humason, 1967); or a combination of physical (heat) and chemical agents that prolong the activity of the δ-endotoxin produced in the cell when the cell is applied to the environment of the target pest(s). Examples of physical means are short wavelength radiation such as gamma-radiation and X-radiation, freezing, UV irradiation, lyophilization, and the like.

The inventors contemplate that any formulation methods known to those of skill in the art may be employed using the proteins disclosed herein to prepare such bioinsecticide compositions. It may be desirable to formulate whole cell preparations, cell extracts, cell suspensions, cell homogenates, cell lysates, cell supernatants, cell filtrates, or cell pellets of a cell culture (preferably a bacterial cell culture such is a B. thuringiensis cell culture described in Table 3) that expresses one or more cry3Bb* DNA segments to produce the encoded Cry3Bb* protein(s) or peptide(s). The methods for preparing such formulations are known to those of skill in the art, and may include, e.g., desiccation, lyophilization, homogenization, extraction, filtration, centrifugation, sedimentation, or concentration of one or more cultures of bacterial cells, such as B. thuringiensis cells described in Table 3, which express the Cry3Bb* peptide(s) of interest.

In one preferred embodiment, the bioinsecticide composition comprises an oil flowable suspension comprising lysed or unlysed bacterial cells, spores, or crystals which contain one or more of the novel crystal proteins disclosed herein. Preferably the cells are B. thuringiensis cells, however, any such bacterial host cell expressing the novel nucleic acid segments disclosed herein and producing a crystal protein is contemplated to be useful, such as Bacillus spp., including B. megaterium, B. subtitis; B. cereus, Escherichia spp., including E. coli, and/or Pseudomonas spp., including P. cepacia, P. aeruginosa, and P. fluorescens. Alternatively, the oil flowable suspension may consist of a combination of one or more of the following compositions: lysed or unlysed bacterial cells, spores, crystals, and/or purified crystal proteins.

In a second preferred embodiment, the bioinsecticide composition comprises a water dispersible granule or powder. This granule or powder may comprise lysed or unlysed bacterial cells, spores, or crystals which contain one or more of the novel crystal proteins disclosed herein. Preferred sources for these compositions include bacterial cells such as B. thuringiensis cells, however, bacteria of the genera Bacillus, Escherichia, and Pseudomonas which have been transformed with a DNA segment disclosed herein and expressing the crystal protein are also contemplated to be useful. Alternatively, the granule or powder may consist of a combination of one or more of the following compositions: lysed or unlysed bacterial cells, spores, crystals, and/or purified crystal proteins.

In a third important embodiment, the bioinsecticide composition comprises a wettable powder, spray, emulsion, colloid, aqueous or organic solution, dust, pellet, or collodial concentrate. Such a composition may contain either unlysed or lysed bacterial cells, spores, crystals, or cell extracts as described above, which contain one or more of the novel crystal proteins disclosed herein. Preferred bacterial cells are B. thuringiensis cells, however, bacteria such as B. megaterium, B. subtilis, B. cereus, E. coli, or Pseudomonas spp. cells transformed with a DNA segment disclosed herein and expressing the crystal protein are also contemplated to be useful. Such dry forms of the insecticidal compositions may be formulated to dissolve immediately upon wetting, or alternatively, dissolve in a controlled-release, sustained-release, or other time-dependent manner. Alternatively, such a composition may consist of a combination of one or more of the following compositions: lysed or unlysed bacterial cells, spores, crystals, and/or purified crystal proteins.

In a fourth important embodiment, the bioinsecticide composition comprises an aqueous solution or suspension or cell culture of lysed or unlysed bacterial cells, spores, crystals, or a mixture of lysed or unlysed bacterial cells, spores, and/or crystals, such as those described above which contain one or more of the novel crystal proteins disclosed herein. Such aqueous solutions or suspensions may be provided as a concentrated stock solution which is diluted prior to application, or alternatively, as a diluted solution ready-to-apply.

For these methods involving application of bacterial cells, the cellular host containing the Crystal protein gene(s) may be grown in any convenient nutrient medium, where the DNA construct provides a selective advantage, providing for a selective medium so that substantially all or all of the cells retain the B. thurinoiensis gene. These cells may then be harvested in accordance with conventional ways. Alternatively, the cells can be treated prior to harvesting.

When the insecticidal compositions comprise B. thuringiensis cells, spores, and/or crystals containing the modified crystal protein(s) of interest, such compositions may be formulated in a variety of ways. They may be employed as wettable powders, granules or dusts, by mixing with various inert materials, such as inorganic minerals (phyllosilicates, carbonates, sulfates, phosphates, and the like) or botanical materials (powdered corncobs, rice hulls, walnut shells, and the like). The formulations may include spreader-sticker adjuvants, stabilizing agents, other pesticidal additives, or surfactants. Liquid formulations may be aqueous-based or non-aqueous and employed as foams, suspensions, emulsifiable concentrates, or the like. The ingredients may include rheological agents, surfactants, emulsifiers, dispersants, or polymers.

Alternatively, the novel Cry3Bb-derived mutated crystal proteins may be prepared by native or recombinant bacterial expression systems in vitro and isolated for subsequent field application. Such protein may be either in crude cell lysates, suspensions, colloids, etc., or alternatively may be purified, refined, buffered, and/or further processed, before formulating in an active biocidal formulation. Likewise, under certain circumstances, it may be desirable to isolate crystals and/or spores from bacterial cultures expressing the crystal protein and apply solutions, suspensions, or collodial preparations of such crystals and/or spores as the active bioinsecticidal composition.

Another important aspect of the invention is a method of controlling coleopteran insects which are susceptible to the novel compositions disclosed herein. Such a method generally comprises contacting the insect or insect population, colony, etc., with an insecticidally-effective amount of a Cry3Bb* crystal protein composition. The method may utilize Cry3Bb* crystal proteins such as those disclosed in SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34 SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, or SEQ ID NO:108, or biologically functional equivalents thereof.

Alternatively, the method may utilize one or more Cry3Bb* crystal proteins which are encoded by the nucleic acid sequences of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5. SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13. SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:101, or SEQ ID NO:107, or by one or more nucleic acid sequences which hybridize to the sequences of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5. SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13. SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:101, or SEQ ID NO:107, under conditions of moderate, or higher, stringency. The methods for identifying sequences which hybridize to those disclosed under conditions of moderate or higher stringency are well-known to those of skill in the art, and are discussed herein.

Regardless of the method of application, the amount of the active component(s) are applied at an insecticidally-effective amount, which will vary depending on such factors as, for example, the specific coleopteran insects to be controlled, the specific plant or crop to be treated, the environmental conditions, and the method, rate, and quantity of application of the insecticidally-active composition.

The insecticide compositions described may be made by formulating either the bacterial cell, crystal and/or spore suspension, or isolated protein component with the desired agriculturally-acceptable carrier. The compositions may be formulated prior to administration in an appropriate means such as lyophilized, freeze-dried, dessicated, or in an aqueous carrier, medium or suitable diluent, such as saline or other buffer. The formulated compositions may be in the form of a dust or granular material, or a suspension in oil (vegetable or mineral), or water or oil/water emulsions, or as a wettable powder, or in combination with any other carrier material suitable for agricultural application. Suitable agricultural carriers can be solid or liquid and are well known in the art. The term "agriculturally-acceptable carrier" covers all adjuvants, e.g., inert components, dispersants, surfactants, tackifiers, binders, etc. that are ordinarily used in insecticide formulation technology; these are well known to those skilled in insecticide formulation. The formulations may be mixed with one or more solid or liquid adjuvants and prepared by various means, e.g., by homogeneously mixing, blending and/or grinding the insecticidal composition with suitable adjuvants using conventional formulation techniques.

The insecticidal compositions of this invention are applied to the environment of the target coleopteran insect, typically onto the foliage of the plant or crop to be protected, by conventional methods, preferably by spraying. The strength and duration of insecticidal application will be set with regard to conditions specific to the particular pest(s), crop(s) to be treated and particular environmental conditions. The proportional ratio of active ingredient to carrier will naturally depend on the chemical nature, solubility, and stability of the insecticidal composition, as well as the particular formulation contemplated.

Other application techniques, e.g., dusting, sprinkling, soaking, soil injection, soil tilling, seed coating, seedling coating, spraying, aerating, misting, atomizing, and the like, are also feasible and may be required under certain circumstances such as e.g., insects that cause root or stalk infestation, or for application to delicate vegetation or ornamental plants. These application procedures are also well-known to those of skill in the art.

The insecticidal composition of the invention may be employed in the method of the invention singly or in combination with other compounds, including and not limited to other pesticides. The method of the invention may also be used in conjunction with other treatments such as surfactants, detergents, polymers or time-release formulations. The insecticidal compositions of the present invention may be formulated for either systemic or topical use.

The concentration of insecticidal composition which is used for environmental, systemic, or foliar application will vary widely depending upon the nature of the particular formulation, means of application, environmental conditions, and degree of biocidal activity. Typically, the bioinsecticidal composition will be present in the applied formulation at a concentration of at least about 1% by weight and may be up to and including about 99% by weight. Dry formulations of the compositions may be from about 1% to about 99% or more by weight of the composition, while liquid formulations may generally comprise from about 1% to about 99% or more of the active ingredient by weight. Formulations which comprise intact bacterial cells will generally contain from about 10⁴ to about 10¹² cells/mg.

The insecticidal formulation may be administered to a particular plant or target area in one or more applications as needed, with a typical field application rate per hectare ranging on the order of from about 1 g to about 1 kg, 2 kg, 5, kg, or more of active ingredient.

4.8 Nucleic Acid Segments as Hybridization Probes and Primers

In addition to their use in directing the expression of crystal proteins or peptides of the present invention, the nucleic acid sequences contemplated herein also have a variety of other uses. For example, they also have utility as probes or primers in nucleic acid hybridization embodiments. As such, it is contemplated that nucleic acid segments that comprise a sequence region that consists of at least a 14 nucleotide long contiguous sequence that has the same sequence as, or is complementary to, a 14 nucleotide long contiguous DNA segment of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5. SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13. SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:101, or SEQ ID NO:107 will find particular utility. Longer contiguous identical or complementary sequences, e.g, those of about 20, 30, 40, 50, 100, 200, 500, 1000, 2000, 5000, 10000 etc. (including all intermediate lengths and up to and including full-length sequences will also be of use in certain embodiments.

The ability of such nucleic acid probes to specifically hybridize to crystal protein-encoding sequences will enable them to be of use in detecting the presence of complementary sequences in a given sample. However, other uses are envisioned, including the use of the sequence information for the preparation of mutant species primers, or primers for use in preparing other genetic constructions.

Nucleic acid molecules having sequence regions consisting of contiguous nucleotide stretches of 10-14, 15-20, 30, 50, or even of 100-200 nucleotides or so, identical or complementary to DNA sequences of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5. SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13. SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, SEQ ID NO:101, or SEQ ID NO:107 are particularly contemplated as hybridization probes for use in, e.g., Southern and Northern blotting. Smaller fragments will generally find use in hybridization embodiments, wherein the length of the contiguous complementary region may be varied, such as between about 10-14 and about 100 or 200 nucleotides, but larger contiguous complementary stretches may be used, according to the length complementary sequences one wishes to detect.

The use of a hybridization probe of about 14 nucleotides in length allows the formation of a duplex molecule that is both stable and selective. Molecules having contiguous complementary sequences over stretches greater than 14 bases in length are generally preferred, though, in order to increase stability and selectivity of the hybrid, and thereby improve the quality and degree of specific hybrid molecules obtained. One will generally prefer to design nucleic acid molecules having gene-complementary stretches of 15 to 20 contiguous nucleotides, or even longer where desired.

Of course, fragments may also be obtained by other techniques such as, e.g., by mechanical shearing or by restriction enzyme digestion. Small nucleic acid segments or fragments may be readily prepared by, for example, directly synthesizing the fragment by chemical means, as is commonly practiced using an automated oligonucleotide synthesizer. Also, fragments may be obtained by application of nucleic acid reproduction technology, such as the PCR™ technology of U.S. Pat. Nos. 4,683,195 and 4,683,202 (each incorporated herein by reference), by introducing selected sequences into recombinant vectors for recombinant production, and by other recombinant DNA techniques generally known to those of skill in the art of molecular biology.

Accordingly, the nucleotide sequences of the invention may be used for their ability to selectively form duplex molecules with complementary stretches of DNA fragments. Depending on the application envisioned, one will desire to employ varying conditions of hybridization to achieve varying degrees of selectivity of probe towards target sequence. For applications requiring high selectivity, one will typically desire to employ relatively stringent conditions to form the hybrids., e.g., one will select relatively low salt and/or high temperature conditions, such as provided by about 0.02 M to about 0.15 M NaCl at temperatures of about 50° C. to about 70° C. Such selective conditions tolerate little, if any, mismatch between the probe and the template or target strand, and would be particularly suitable for isolating crystal protein-encoding DNA segments. Detection of DNA segments via hybridization is well-known to those of skill in the art, and the teachings of U.S. Pat. Nos. 4,965,188 and 5,176,995 (each incorporated herein by reference) are exemplary of the methods of hybridization analyses. Teachings such as those found in the texts of Maloy et al., 1994; Segal 1976; Prokop, 1991; and Kuby, 1994, are particularly relevant.

Of course, for some applications, for example, where one desires to prepare mutants employing a mutant primer strand hybridized to an underlying template or where one seeks to isolate crystal protein-encoding sequences from related species, functional equivalents, or the like, less stringent hybridization conditions will typically be needed in order to allow formation of the heteroduplex. In these circumstances, one may desire to employ conditions such as about 0.15 M to about 0.9 M salt, at temperatures ranging from about 20° C. to about 55° C. Cross-hybridizing species can thereby be readily identified as positively hybridizing signals with respect to control hybridizations. In any case, it is generally appreciated that conditions can be rendered more stringent by the addition of increasing amounts of formamide, which serves to destabilize the hybrid duplex in the same manner as increased temperature. Thus, hybridization conditions can be readily manipulated, and thus will generally be a method of choice depending on the desired results.

In certain embodiments, it will be advantageous to employ nucleic acid sequences of the present invention in combination with an appropriate means, such as a label, for determining hybridization. A wide variety of appropriate indicator means are known in the art, including fluorescent, radioactive, enzymatic or other ligands, such as avidin/biotin, which are capable of giving a detectable signal. In preferred embodiments, one will likely desire to employ a fluorescent label or an enzyme tag, such as urease, alkaline phosphatase or peroxidase, instead of radioactive or other environmental undesirable reagents. In the case of enzyme tags, colorimetric indicator substrates are known that can be employed to provide a means visible to the human eye or spectrophotometrically, to identify specific hybridization with complementary nucleic acid-containing samples.

In general, it is envisioned that the hybridization probes described herein will be useful both as reagents in solution hybridization as well as in embodiments employing a solid phase. In embodiments involving a solid phase, the test DNA (or RNA) is adsorbed or otherwise affixed to a selected matrix or surface. This fixed, single-stranded nucleic acid is then subjected to specific hybridization with selected probes under desired conditions. The selected conditions will depend on the particular circumstances based on the particular criteria required (depending, for example, on the G+C content, type of target nucleic acid, source of nucleic acid, size of hybridization probe, etc.). Following washing of the hybridized surface so as to remove nonspecifically bound probe molecules, specific hybridization is detected, or even quantitated, by means of the label.

4.9 Characteristics of Modified Cry3 δ-Endotoxins

The present invention provides novel polypeptides that define a whole or a portion of a B. thuringiensis cry3Bb.60, cry3Bb.11221, cry3Bb.11222, cry3Bb.11223, cry3Bb.11224, cry3Bb.11225, cry3Bb.11226, cry3Bb.11227, cry3Bb.11228, cry3Bb.11229, cry3Bb.11230, cry3Bb.11231, cry3Bb.11232, cry3Bb.11233, cry3Bb.11234, cry3Bb.11235, cry3Bb.11236, cry3Bb.11237, cry3Bb.11238, cry3Bb.11239, cry3Bb.11241, cry3Bb.11242, cry3Bb.11032, cry3Bb.11035, cry3Bb.11036, cry3Bb.11046, cry3Bb.11048, cry3Bb.11051, cry3Bb.11057, cry3Bb.11058, cry3Bb.11081, cry3Bb.11082, cry3Bb.11083, cry3Bb.11084, cry3Bb.11095 and cry3Bb.11098-encoded crystal protein.

4.10 Crystal Protein Nomenclature

The inventors have arbitrarily assigned the designations Cry3Bb.60, Cry3Bb.11221, Cry3Bb.11222, Cry3Bb.11223, Cry3Bb.11224, Cry3Bb.11225, Cry3Bb.11226, Cry3Bb.11227, Cry3Bb.11228, Cry3Bb.11229, Cry3Bb.11230, Cry3Bb.11231, Cry3Bb.11232, Cry3Bb.11233, Cry3Bb.11234, Cry3Bb.11235, Cry3Bb.11236, Cry3Bb.11237, Cry3Bb.11238, Cry3Bb.11239, Cry3Bb.11241, Cry3Bb.11242, Cry3Bb.11032, Cry3Bb.11035, Cry3Bb.11036, Cry3Bb.11046, Cry3Bb.11048, Cry3Bb.11051, Cry3Bb.11057, Cry3Bb.11058, Cry3Bb.11081, Cry3Bb.11082, Cry3Bb.11083, Cry3Bb.11084, Cry3Bb.11095 and Cry3Bb.11098 to the novel proteins of the invention.

Likewise, the arbitrary designations of cry3Bb.60, cry3Bb.11221, cry3Bb.11222, cry3Bb.11223, cry3Bb.11224, cry3Bb.11225, cry3Bb.11226, cry3Bb.11227, cry3Bb.11228, cry3Bb.11229, cry3Bb.11230, cry3Bb.11231, cry3Bb.11232, cry3Bb.11233, cry3Bb.11234, cry3Bb.11235, cry3Bb.11236, cry3Bb.11237, cry3Bb.11238, cry3Bb.11239, cry3Bb.11241, cry3Bb.11242, cry3Bb.11032, cry3Bb.11035, cry3Bb.11036, cry3Bb.11046, cry3Bb.11048, cry3Bb.11051, cry3Bb.11057, cry3Bb.11058, cry3Bb.11081, cry3Bb.11082, cry3Bb.11083, cry3Bb.11084, cry3Bb.11095 and Cry3Bb.11098 have been assigned to the novel nucleic acid sequences which encode these polypeptides, respectively. While formal assignment of gene and protein designations based on the revised nomenclature of crystal protein endotoxins (Table 1) may be made by the committee on the nomenclature of B. thuringiensis, any re-designations of the compositions of the present invention are also contemplated to be fully within the scope of the present disclosure.

4.11 Transformed Host Cells and Transgenic Plants

A bacterium, a yeast cell, or a plant cell or a plant transformed with an expression vector of the present invention is also contemplated. A transgenic bacterium, yeast cell, plant cell or plant derived from such a transformed or transgenic cell is also one aspect of the invention.

Such transformed host cells are often desirable for use in the production of endotoxins and for expression of the various DNA gene constrcuts disclosed herein. In some aspects of the invention, it is often desirable to modulate, regulate, or otherwise control the expression of the gene segments disclosed herein. Such methods are routine to those of skill in the molecular genetic arts. Typically, when increased or over-expression of a particular gene is desired, various manipulations may be employed for enhancing the expression of the messenger RNA, particularly by using an active promoter, as well as by employing sequences, which enhance the stability of the messenger RNA in the particular transformed host cell.

Typically, the initiation and translational termination region will involve stop codon(s), a terminator region, and optionally, a polyadenylation signal. In the direction of transcription, namely in the 5' to 3' direction of the coding or sense sequence, the construct will involve the transcriptional regulatory region, if any, and the promoter, where the regulatory region may be either 5' or 3' of the promoter, the ribosomal binding site, the initiation codon, the structural gene having an open reading frame in phase with the initiation codon, the stop codon(s), the polyadenylation signal sequence, if any, and the terminator region. This sequence as a double strand may be used by itself for transformation of a microorganism host, but will usually be included with a DNA sequence involving a marker, where the second DNA sequence may be joined to the δ-endotoxin expression construct during introduction of the DNA into the host.

By a marker is intended a structural gene which provides for selection of those hosts which have been modified or transformed. The marker will normally provide for selective advantage, for example, providing for biocide resistance, e.g., resistance to antibiotics or heavy metals; complementation, so as to provide prototropy to an auxotrophic host, or the like. Preferably, complementation is employed, so that the modified host may not only be selected, but may also be competitive in the field. One or more markers may be employed in the development of the constructs, as well as for modifying the host. The organisms may be further modified by providing for a competitive advantage against other wild-type microor- ganisms in the field. For example, genes expressing metal chelating agents, e.g., siderophores, may be introduced into the host along with the structural gene expressing the δ-endotoxin. In this manner, the enhanced expression of a siderophore may provide for a competitive advantage for the δ-endotoxin-producing host, so that it may effectively compete with the wild-type microorganisms and stably occupy a niche in the environment.

Where no functional replication system is present, the construct will also include a sequence of at least 50 basepairs (bp), preferably at least about 100 bp, and usually not more than about 1000 bp of a sequence homologous with a sequence in the host. In this way, the probability of legitimate recombination is enhanced, so that the gene will be integrated into the host and stably maintained by the host. Desirably, the δ-endotoxin gene will be in close proximity to the gene providing for complementation as well as the gene providing for the competitive advantage. Therefore, in the event that a δ-endotoxin gene is lost, the resulting organism will be likely to also lose the complementing gene and/or the gene providing for the competitive advantage, so that it will be unable to compete in the environment with the gene retaining the intact construct.

The crystal protein-encoding gene can be introduced between the transcriptional and translational initiation region and the transcriptional and translational termination region, so as to be under the regulatory control of the initiation region. This construct will be in- cluded in a plasmid, which will include at least one replication system, but may include more than one, where one replication system is employed for cloning during the development of the plasmid and the second replication system is necessary for functioning in the ultimate host. In addition, one or more markers may be present, which have been described previously. Where integration is desired, the plasmid will desirably include a sequence homologous with the host genome.

The transformants can be isolated in accordance with conventional ways, usually employing a selection technique, which allows for selection of the desired organism as against unmodified organisms or transferring organisms, when present. The transformants then can be tested for pesticidal activity.

Suitable host cells, where the pesticide-containing cells will be treated to prolong the activity of the δ-endotoxin in the cell when the then treated cell is applied to the environment of target pest(s), may include either prokaryotes or eukaryotes, normally being limited to those cells which do not produce substances toxic to higher organisms, such as mammals. However, organisms which produce substances toxic to higher organisms could be used, where the δ-endotoxin is unstable or the level of application sufficiently low as to avoid any possibility of toxicity to a mammalian host. As hosts, of particular interest will be the prokaryotes and the lower eukaryotes, such as fungi. Illustrative prokaryotes, both Gram-negative and -positive, include Enterobacteriaceae, such as Escherichia, Erwinia, Shigella, Salmonella, and Proteus; Bacillaceae; Rhizobiceae., such as Rhizobium; Spirillaceae, such as photobacterium, Zymomonas, Serratia, Aeromonas, Vibrio, Desulfovibdo, Spirillum; Lactobacillaceae; phylloplane organisms such as members of the Pseudomonadaceae (including Pseudomonas spp. and Acetobacter spp.); Azotobcacteraceae and Nitrobacteraceae; Flavobacterium spp.; members of the Bacillaceae such as Lactobacillus spp., Bifidobacterium, and Bacillus spp., and the like. Particularly preferred host cells include Pseudomonas aeruginosa, Pseudomonas fluorescens, Bacillus thuringiensis, Escherichia coli, Bacillus subtilis, and the like.

Among eukaryotes are fungi, such as Plycomycetes and Ascomycetes, which includes yeast, such as Schizosaccharomyces; and Basidiomycetes, Rhodotorula, Aureobasidium, Sporobolomyces, Saccharomyces spp., and Spotobolomyces spp.

Characteristics of particular interest in selecting a host cell for purposes of production include ease of introducing the δ-endotoxin gene into the host, availability of expression systems, efficiency of expression, stability of the pesticide in the host, and the presence of auxiliary genetic capabilities. Characteristics of interest for use as a pesticide microcapsule include protective qualities for the pesticide, such as thick cell walls, pigmentation, and intracellular packaging or formation of inclusion bodies; leaf affinity; lack of mammalian toxicity; attractiveness to pests for ingestion; ease of killing and fixing without damage to the δ-endotoxin; and the like. Other considerations include ease of formulation and handling, economics, storage stability, and the like.

The cell will usually be intact and be substantially in the proliferative form when treated, rather than in a spore form, although in some instances spores may be employed. Treatment of the recombinant microbial cell can be done as disclosed infra. The treated cells generally will have enhanced structural stability which will enhance resistance to environmental conditions.

Genes or other nucleic acid segments, as disclosed herein, can be inserted into host cells using a variety of techniques which are well known in the art. For example, a large number of cloning vectors comprising a replication system in E. coli and a marker that permits selection of the transformed cells are available for preparation for the insertion of foreign genes into higher organisms, including plants. The vectors comprise, for example, pBR322, pUC series, M13mp series, pACYC184, etc. Accordingly, the sequence coding for the δ-endotoxin can be inserted into the vector at a suitable restriction site. The resulting plasmid is used for transformation into E. coli. The E. coli cells are cultivated in a suitable nutrient medium, then harvested and lysed. The plasmid is recovered. Sequence analysis, restriction analysis, electrophoresis, and other biochemical-molecular biological methods are generally carried out as methods of analysis. After each manipulation, the DNA sequence used can be cleaved and joined to the next DNA sequence. Each plasmid sequence can be cloned in the same or other plasmids. Depending on the method of inserting desired genes into the plant, other DNA sequences may be necessary.

Methods for DNA transformation of plaint cells include Agrobacterium-mediated plant transformation, protoplast transformation, gene transfer into pollen, injection into reproductive organs, injection into immature embryos and particle bombardment. Each of these methods has distinct advantages and disadvantages. Thus, one particular method of introducing genes into a particular plant strain may not necessarily be the most effective for another plant strain, but it is well known which methods are useful for a particular plant strain.

Suitable methods are believed to include virtually any method by which DNA can be introduced into a cell, such as by Agrobacterium infection, direct delivery of DNA such as, for example, by PEG-mediated transformation of protoplasts (Omirulleh et al., 1993), by desiccation/inhibition-mediated DNA uptake, by electroporation, by agitation with silicon carbide fibers, by acceleration of DNA coated particles, etc. In certain embodiments, acceleration methods are preferred and include, for example, microprojectile bombardment and the like.

Technology for introduction of DNA into cells is well-known to those of skill in the art. Four general methods for delivering a gene into cells have been described: (1) chemical methods (Graham and van der Eb, 1973; Zatloukal et al., 1992); (2) physical methods such as microinjection (Capecchi, 1980), electroporation (Wong and Neumann, 1982; Fromm et al., 1985) and the gene gun (Johnston and Tang, 1994; Fynan et al., 1993); (3) viral vectors (Clapp, 1993; Lu et al., 1993; Eglitis and Anderson, 1988; Eglitis et al., 1988); and (4) receptor-mediated mechanisms (Curiel et al., 1991; 1992; Wagner et al., 1992).

A large number of techniques are available for inserting DNA into a plant host cell. Those techniques include transformation with T-DNA using Agrobacterium tumefaciens or Agrobactedum rhizogenes as transformation agent, fusion, injection, or electroporation as well as other possible methods. If agrobacteria are used for the transformation, the DNA to be inserted has to be cloned into special plasmid, namely either into an intermediate vector or into a binary vector. The intermediate vectors can be integrated into the Ti or Ri plasmid by homologous recombination owing to sequences that are homologous to sequences in the T-DNA. The Ti or Ri plasmid also comprises the vir region necessary for the transfer of the T-DNA.

Intermediate vectors cannot replicate themselves in agrobacteria. The intermediate vector can be transferred into Agrobacterium tumefaciens by means of a helper plasmid (conjugation). Binary vectors can replicate themselves both in E. coli and in agrobacteria. They comprise a selection marker gene and a linker or polylinker which are framed by the right and left T-DNA border regions. They can be transformed directly into agrobacteria (Holsters et al., 1978). The agrobacterium used as host cell is to comprise a plasmid carrying a vir region. The vir region is necessary for the transfer of the T-DNA into the plant cell. Additional t-DNA may be contained. The bacterium so transformed is used for the transformation of plant cells. Plant explants can advantageously be cultivated with Agrobacterium tumefaciens or Agrobacterium rhizogenes for the transfer of the DNA into the plant cell. Whole plants can then be regenerated from the infected plant material (for example, pieces of leaf, segments of stalk, roots, but also protoplasts or suspension-cultivated cells) in a suitable medium, which may contain antibiotics or biocides for selection. The plants so obtained can then be tested for the presence of the inserted DNA. No special demands are made of the plasmids in the case of injection and electroporation. It is possible to use ordinary plasmids, such as, for example, pUC derivatives. If, for example, the Ti or Ri plasmid is used for the transformation of the plant cell, then at least the right border, but often the right and the left border of the Ti or Ri plasmid T-DNA, has to be joined as the flanking region of the genes to be inserted. The use of T-DNA for the transformation of plant cells has been intensively researched and sufficiently described in Eur. Pat. Appl. No. EP 120 516; Hockema (1985); An et al., 1985, 1 Herrera-Estrella et al., (1983), Bevan et. al., (1983), and Klee et al, (1985).

A particularly useful Ti plasmid cassette vector for transformation of dicotyledonous plants consists of the enhanced CaMV35S promoter (EN35S) and the 3' end including polyadenylation signals from a soybean gene encoding the α'-subunit of β-conglycinin. Between these two elements is a multilinker containing multiple restriction sites for the insertion of genes of interest.

The vector preferably contains a segment of pBR322 which provides an origin of replication in E. coli and a region for homologous recombination with the disarmed T-DNA in Agrobacterium strain ACO; the oriV region from the broad host range plasmid RK1; the streptomycin/spectinomycin resistance gene from Tn7; and a chimeric NPTII gene, containing the CaMV35S promoter and the nopaline synthase (NOS) 3' end, which provides kanamycin resistance in transformed plant cells.

Optionally, the enhanced CaMV35S promoter may be replaced with the 1.5 kb mannopine synthase (MAS) promoter (Velten et al., 1984). After incorporation of a DNA construct into the vector, it is introduced into A. tumefaciens strain ACO which contains a disarmed Ti plasmid. Cointegrate Ti plasmid vectcors are selected and subsequentially may be used to transform a dicotyledonous plant.

A. tumefaciens ACO is a disarmed strain similar to pTiB6SE described by Fraley et al. (1985). For construction of ACO the starting Agrobacterium strain was the strain A208 which contains a nopaline-type Ti plasmid. The Ti plasmid was disarmed in a manner similar to that described by Fraley et al. (1985) so that essentially all of the native T-DNA was removed except for the left border and a few hundred base pairs of T-DNA inside the left border. The remainder of the T-DNA extending to a point just beyond the right border was replaced with a novel piece of DNA including (from left to right) a segment of pBR322, the oriV region from plasmid RK2, and the kanamycin resistance gene from Tn601. The pBR322 and oriV segments are similar to these segments and provide a region of homology for cointegrate formation.

Once the inserted DNA has been integrated in the genome, it is relatively stable there and, as a rule, does not come out again. It normally contains a selection marker that confers on the transformed plant cells resistance to a biocide or an antibiotic, such as kanamycin, G 418, bleomycin, hygromycin, or chloramphenicol, inter alia. The individually employed marker should accordingly permit the selection of transformed cells rather than cells that do not contain the inserted DNA.

4.11.1 Electroporation

The application of brief, high-voltage electric pulses to a variety of animal and plant cells leads to the formation of nanometer-sized pores in the plasma membrane. DNA is taken directly into the cell cytoplasm either through these pores or as a consequence of the redistribution of membrane components that accompanies closure of the pores. Electroporation can be extremely efficient and can be used both for transient expression of clones genes and for establishment of cell lines that carry integrated copies of the gene of interest. Electroporation, in contrast to calcium phosphate-mediated transfection and protoplast fusion, frequently gives rise to cell lines that carry one, or at most a few, integrated copies of the foreign DNA.

The introduction of DNA by means of electroporation, is well-known to those of skill in the art. In this method, certain cell wall-degrading enzymes, such as pectin-degrading enzymes, are employed to render the target recipient cells more susceptible to transformation by electroporation than untreated cells. Alternatively, recipient cells are made more susceptible to transformation, by mechanical Wounding. To effect transformation by electroporation one may employ either friable tissues such as a suspension culture of cells, or embryogenic callus, or alternatively, one may transform immature embryos or other organized tissues directly. One would partially degrade the cell walls of the chosen cells by exposing them to pectin-degrading enzymes (pectolyases) or mechanically wounding in a controlled manner. Such cells would then be recipient to DNA transfer by electroporation, which may be carried out at this stage, and transformed cells then identified by a suitable selection or screening protocol dependent on the nature of the newly incorporated DNA.

4.11.2 Microprojectile Bombardment

A further advantageous method for delivering transforming DNA segments to plant cells is microprojectile bombardment. In this method, particles may be coated with nucleic acids and delivered into cells by a propelling force. Exemplary particles include those comprised of tungsten, gold, platinum, and the like.

An advantage of microprojectile bombardment, in addition to it being an effective means of reproducibly stably transforming monocots, is that neither the isolation of protoplasts (Cristou et al., 1988) nor the susceptibility to Agrobacterium infection is required. An illustrative embodiment of a method for delivering DNA into maize cells by acceleration is a Biolistics Particle Delivery System, which can be used to propel particles coated with DNA or cells through a screen, such as a stainless steel or Nytex screen, onto a filter surface covered with corn cells cultured in suspension. The screen disperses the particles so that they are not delivered to the recipient cells in large aggregates. It is believed that a screen intervening between the projectile apparatus and the cells to be bombarded reduces the size of projectiles aggregate and may contribute to a higher frequency of transformation by reducing damage inflicted on the recipient cells by projectiles that are too large.

For the bombardment, cells in suspension are preferably concentrated on filters or solid culture medium. Alternatively, immature embryos or other target cells may be arranged on solid culture medium. The cells to be bombarded are positioned at an appropriate distance below the macroprojectile stopping plate. If desired, one or more screens are also positioned between the acceleration device and the cells to be bombarded. Through the use of techniques set forth herein one may obtain up to 1000 or more foci of cells transiently expressing a marker gene. The number of cells in a focus which express the exogenous gene product 48 hours post-bombardment often range from 1 to 10 and average 1 to 3.

In bombardment transformation, one may optimize the prebombardment culturing conditions and the bombardment parameters to yield the maximum numbers of stable transformants. Both the physical and biological parameters for bombardment are important in this technology. Physical factors are those that involve manipulating the DNA/microprojectile precipitate or those that affect the flight and velocity of either the macro- or microprojectiles. Biological factors include all steps involved in manipulation of cells before and immediately after bombardment, the osmotic adjustment of target cells to help alleviate the trauma associated with bombardment, and also the nature of the transforming DNA, such as linearized DNA or intact supercoiled plasmids. It is believed that pre-bombardment manipulations are especially important for successful transformation of immature embryos.

Accordingly, it is contemplated that one may wish to adjust various of the bombardment parameters in small scale studies to fully optimize the conditions. One may particularly wish to adjust physical parameters such as gap distance, flight distance, tissue distance, and helium pressure. One may also minimize the trauma reduction factors (TRFs) by modifying conditions which influence the physiological state of the recipient cells and which may therefore influence transformation and integration efficiencies. For example, the osmotic state, tissue hydration and the subculture stage or cell cycle of the recipient cells may be adjusted for optimum transformation. The execution of other routine adjustments will be known to those of skill in the art in light of the present disclosure.

4.11.3 Agrobacterium-Mediated Transfer

Agrobacterium-mediated transfer is a widely applicable system for introducing genes into plant cells because the DNA can be introduced into whole plant tissues, thereby bypassing the need for regeneration of an intact plant from a protoplast. The use of Agrobacterium-mediated plant integrating vectors to introduce DNA into plant cells is well known in the art. See, for example, the methods described (Fraley et al., 1985; Rogers et al, 1987). Further, the integration of the Ti-DNA is a relatively precise process resulting in few rearrangements. The region of DNA to be transferred is defined by the border sequences, and intervening DNA is usually inserted into the plant genome as described (Spielmann et al., 1986; Jorgensen et al., 1987).

Modem Agrobacterium transformation vectors are capable of replication in E. coli as well as Agrobacterium, allowing for convenient manipulations as described (Klee et al., 1985). Moreover, recent technological advances in vectors for Agrobacterium-mediated gene transfer have improved the arrangement of genes and restriction sites in the vectors to facilitate construction of vectors capable of expressing various polypeptide coding genes. The vectors described (Rogers et al., 1987), have convenient multi-linker regions flanked by a promoter and a polyadenylation site for direct expression of inserted polypeptide coding genes and are suitable for present purposes. In addition, Agrobacterium containing both armed and disarmed Ti genes can be used for the transformations. In those plant strains where Agrobacterium-mediated transformation is efficient, it is the method of choice because of the facile and defined nature of the gene transfer.

Agrobacterium-mediated transformation of leaf disks and other tissues such as cotyledons and hypocotyls appears to be limited to plants that Agrobacterium naturally infects. Agrobacterium-mediated transformation is most efficient in dicotyledonous plants. Few monocots appear to be natural hosts for Agrobacterium, although transgenic plants have been produced in asparagus using Agrobacterium vectors as described (Bytebier et al., 1987). Therefore, commercially important cereal grains such as rice, corn, and wheat must usually be transformed using alternative methods. However, as mentioned above, the transformation of asparagus using Agrobacterium can also be achieved (see, for example, Bytebier et al., 1987).

A transgenic plant formed using Agrobacterium transformation methods typically contains a single gene on one chromosome. Such transgenic plants can be referred to as being heterozygous for the added gene. However, inasmuch as use of the word "heterozygous" usually implies the presence of a complementary gene at the same locus of the second chromosome of a pair of chromosomes, and there is no such gene in a plant containing one added gene as here, it is believed that a more accurate name for such a plant is an independent segregant, because the added, exogenous gene segregates independently during mitosis and meiosis.

More preferred is a transgenic plant that is homozygous for the added structural gene; i.e., a transgenic plant that contains two added genes, one gene at the same locus on each chromosome of a chromosome pair. A homozygous transgenic plant can be obtained by sexually mating (selfing) an independent segregant transgenic plant that contains a single added gene, germinating some of the seed produced and analyzing the resulting plants produced for enhanced carboxylase activity relative to a control (native, non-transgenic) or an independent segregant transgenic plant.

It is to be understood that two different transgenic plants can also be mated to produce offspring that contain two independently segregating added, exogenous genes. Selfing of appropriate progeny can produce plants that are homozygous for both added, exogenous genes that encode a polypeptide of interest. Back-crossing to a parental plant and out-crossing with a non-transgenic plant are also contemplated.

Transformation of plant protoplasts can be achieved using methods based on calcium phosphate precipitation, polyethylene glycol treatment, electroporation, and combinations of these treatments (see, e.g., Potrykus et al., 1985; Lorz et al., 1985; Fromm et al., 1985; Uchimiya et al., 1986; Callis et al., 1987; Marcotte et al., 1988).

Application of these systems to different plant strains depends upon the ability to regenerate that particular plant strain from protoplasts. Illustrative methods for the regeneration of cereals from protoplasts are described (Fujimura et al., 1985; Toriyama et al., 1986; Yamada et al., 1986; Abdullah et al, 1986).

To transform plant strains that cannot be successfully regenerated from protoplasts, other ways to introduce DNA into intact cells or tissues can be utilized. For example, regeneration of cereals from immature embryos or explants can be effected as described (Vasil, 1988). In addition, "particle gun" or high-velocity microprojectile technology can be utilized (Vasil, 1992).

Using that latter technology, DNA is carried through the cell wall and into the cytoplasm on the surface of small metal particles as described (Klein et al., 1987; Klein et al, 1988; McCabe et al., 1988). The metal particles penetrate through several layers of cells and thus allow the transformation of cells within tissue explants.

4.11.4 Gene Expression in Plants

Although great progress has been made in recent years with respect to preparation of transgenic plants which express bacterial proteins such as B. thuringiensis crystal proteins, the results of expressing native bacterial genes in plants are often disappointing. Unlike microbial genetics, little was known by early plant geneticists about the factors which affected heterologous expression of foreign genes in plants. In recent years, however, several potential factors have been implicated as responsible in varying degrees for the level of protein expression from a particular coding sequence. For example, scientists now know that maintaining a significant level of a particular mRNA in the cell is indeed a critical factor. Unfortunately, the causes for low steady state levels of mRNA encoding foreign proteins are many. First, full length RNA synthesis may not occur at a high frequency. This could, for example, be caused by the premature termination of RNA during transcription or due to unexpected mRNA processing during transcription. Second, full length RNA may be produced in the plant cell, but then processed (splicing, polyA addition) in the nucleus in a fashion that creates a nonfunctional mRNA. If the RNA is not properly synthesized, terminated and polyadenylated, it cannot move to the cytoplasm for translation. Similarly, in the cytoplasm, if mRNAs have reduced half lives (which are determined by their primary or secondary sequence) inisufficient protein product will be produced. In addition, there is an effect, whose magnitude is uncertain, of translational efficiency on mRNA half-life. In addition, every RNA molecule folds into a particular structure, or perhaps family of structures, which is determined by its sequence. The particular structure of any RNA might lead to greater or lesser stability in the cytoplasm. Structure per se is probably also a determinant of mRNA processing in the nucleus. Unfortunately, it is impossible to predict, and nearly impossible to determine, the structure of any RNA (except for tRNA) in vitro or in vivo. However, it is likely that dramatically changing the sequence of an RNA will have a large effect on its folded structure It is likely that structure per se or particular structural features also have a role in determining RNA stability.

To overcome these limitations in foreign gene expression, researchers have identified particular sequences and signals in RNAs that have the potential for having a specific effect on RNA stability. In certain embodiments of the invention, therefore, there is a desire to optimize expression of the disclosed nucleic acid segments in planta. One particular method of doing so, is by alteration of the bacterial gene to remove sequences or motifs which decrease expression in a transformed plant cell. The process of engineering a coding sequence for optimal expression in planta is often referred to as "plantizing" a DNA sequence.

Particularly problematic sequences are those which are A+T rich. Unfortunately, since B. thuringiensis has an A+T rich genome, native crystal protein gene sequences must often be modified for optimal expression in a plant. The sequence motif ATTTA (or AUUUA as it appears in RNA) has been implicated as a destabilizing sequence in mammalian cell mRNA (Shaw and Kamen, 1986). Many short lived mRNAs have A+T rich 3' untranslated regions, and these regions often have the ATTTA sequence, sometimes present in multiple copies or as multimers (e.g., ATTTATTTA . . . ). Shaw and Kamen showed that the transfer of the 3' end of an unstable mRNA to a stable RNA (globin or VAl) decreased the stable RNA's half life dramatically. They further showed that a pentamer of ATTTA had a profound destabilizing effect on a stable message, and that this signal could exert its effect whether it was located at the 3' end or within the coding sequence. However, the number of ATTTA sequences and/or the sequence context in which they occur also appear to be important in determining whether they function as destabilizing sequences. Shaw and Kamen showed that a trimer of ATTTA had much less effect than a pentamer on mRNA stability and a dimer or a monomer had no effect on stability (Shaw and Kamen, 1987). Note that multimers of ATTTA such as a pentamer automatically create an A+T rich region. This was shown to be a cytoplasmic effect, not nuclear. In other unstable mRNAs, the ATTTA sequence may be present in only a single copy, but it is often contained in an A+T rich region. From the animal cell data collected to date, it appears that ATTTA at least in some contexts is important in stability but it is not yet possible to predict which occurrences of ATTTA are destabiling elements or whether any of these effects are likely to be seen in plants.

Some studies on mRNA degradation in animal cells also indicate that RNA degradation may begin in some cases with nucleolytic attack in A+T rich regions. It is not clear if these cleavages occur at ATTTA sequences. There are also examples of mRNAs that have differential stability depending on the cell type in which they are expressed or on the stage within the cell cycle at which they are expressed. For example, histone mRNAs are stable during DNA synthesis but unstable if DNA synthesis is disrupted. The 3' end of some histone mRNAs seems to be responsible for this effect (Pandey and Marzluff, 1987). It does not appear to be mediated by ATTTA, nor is it clear what controls the differential stability of this mRNA. Another example is the differential stability of IgG mRNA in B lymphocytes during B cell maturation (Genovese and Milcarek, 1988). A final example is the instability of a mutant β-thallesemic globin mRNA. In bone marrow cells, where this gene is normally expressed, the mutant mRNA is unstable, while the wild-type mRNA is stable. When the mutant gene is expressed in HeLa or L cells in vitro, the mutant mRNA shows no instability (Lim et al., 1988). These examples all provide evidence that mRNA stability can be mediated by cell type or cell cycle specific factors. Furthermore this type of instability is not yet associated with specific sequences. Given these uncertainties, it is not possible to predict which RNAs are likely to be unstable in a given cell. In addition, even the ATTTA motif may act differentially depending on the nature of the cell in which the RNA is present. Shaw and Kamen (1987) have reported that activation of protein kinase C can block degradation mediated by ATTTA.

The addition of a polyadenylate string to the 3' end is common to most eukaryotic mRNAs, both plant and animal. The currently accepted view of polyA addition is that the nascent transcript extends beyond the mature 3' terminus. Contained within this transcript are signals for polyadenylation and proper 3' end formation. This processing at the 3' end involves cleavage of the mRNA and addition of polyA to the mature 3' end. By searching for consensus sequences near the polyA tract in both plant and animal mRNAs, it has been possible to identify consensus sequences that apparently are involved in polyA addition and 3' end cleavage. The same consensus sequences seem to be important to both of these processes. These signals are typically a variation on the sequence AATAAA. In animal cells, some variants of this sequence that are functional have been identified; in plant cells there seems to be an extended range of functional sequences (Wickens and Stephenson, 1984; Dean et al., 1986). Because all of these consensus sequences are variations on AATAAA, they all are A+T rich sequences. This sequence is typically found 15 to 20 bp before the polyA tract in a mature mRNA. Studies in animal cells indicate that this sequence is involved in both polyA addition and 3' maturation. Site directed mutations in this sequence can disrupt these functions (Conway and Wickens, 1988; Wickens et al., 1987). However, it has also been observed that sequences up to 50 to 100 bp 3' to the putative polyA signal are also required; i.e., a gene that has a normal AATAAA but has been replaced or disrupted downstream does not get properly polyadenylated (Gil and Proudfoot, 1984; Sadofsky and Alwine, 1984; McDevitt et al., 1984). That is, the polyA signal itself is not sufficient for complete and proper processing. It is not yet known what specific downstream sequences are required in addition to the polyA signal, or if there is a specific sequence that has this function. Therefore, sequence analysis can only identify potential polyA signals.

In naturally occurring mRNAs that are normally polyadenylated, it has been observed that disruption of this process, either by altering the polyA signal or other sequences in the mRNA, profound effects can be obtained in the level of functional mRNA. This has been observed in several naturally occurring mRNAs, with results that are gene-specific so far.

It has been shown that in natural mRNAs proper polyadenylation is important in mRNA accumulation, and that disruption of this process can effect mRNA levels significantly. However, insufficient knowledge exists to predict the effect of changes in a normal gene. In a heterologous gene, it is even harder to predict the consequences. However, it is possible that the putative sites identified are dysfunctional. That is, these sites may not act as proper polyA sites, but instead function as aberrant sites that give rise to unstable mRNAs.

In animal cell systems, AATAAA is by far the most common signal identified in mRNAs upstream of the polyA, but at least four variants have also been found (Wickens and Stephenson, 1984). In plants, not nearly so much analysis has been done, but it is clear that multiple sequences similar to AATAAA can be used. The plant sites in Table 5 called major or minor refer only to the study of Dean et al. (1986) which analyzed only three types of plant gene. The designation of polyadenylation sites as major or minor refers only to the frequency of their occurrence as functional sites in naturally occurring genes that have been analyzed. In the case of plants this is a very limited database. It is hard to predict with any certainty that a site designated major or minor is more or less likely to function partially or completely when found in a heterologous gene such as those encoding the crystal proteins of the present invention.

                  TABLE 5                                                          ______________________________________                                         POLYADENYLATION SITES IN PLANT GENES                                           ______________________________________                                         PA          AATAAA   Major consensus site                                      P1A         AATAAT   Major plant site                                          P2A         AACCAA   Minor plant site                                          P3A         ATATAA   "                                                         P4A         AATCAA   "                                                         P5A         ATACTA   "                                                         P6A         ATAAAA   "                                                         P7A         ATGAAA   "                                                         P8A         AAGCAT   "                                                         P9A         ATTAAT   "                                                         P10A        ATACAT   "                                                         P11A        AAAATA   "                                                         P12A        ATTAAA   Minor animal site                                         P13A        AATTAA   "                                                         P14A        AATACA   "                                                         P15A        CATAAA   "                                                         ______________________________________                                    

The present invention provides a method for preparing synthetic plant genes which genes express their protein product at levels significantly higher than the wild-type genes which were commonly employed in plant transformation heretofore. In another aspect, the present invention also provides novel synthetic plant genes which encode non-plant proteins.

As described above, the expression of native B. thuringiensis genes in plants is often problematic. The nature of the coding sequences of B. thuringiensis genes distinguishes them from plant genes as well as many other heterologous genes expressed in plants. In particular, B. thuringiensis genes are very rich (˜62%) in adenine (A) and thymine (T) while plant genes and most other bacterial genes which have been expressed in plants are on the order of 45-55% A+T.

Due to the degeneracy of the genetic code and the limited number of codon choices for any amino acid, most of the "excess" A+T of the structural coding sequences of some Bacillus species are found in the third position of the codons. That is, genes of some Bacillus species have A or T as the third nucleotide in many codons. Thus A+T content in part can determine codon usage bias. In addition, it is clear that genes evolve for maximum function in the organism in which they evolve. This means that particular nucleotide sequences found in a gene from one organism, where they may play no role except to code for a particular stretch of amino acids, have the potential to be recognized as gene control elements in another organism (such as transcriptional promoters or terminators, polyA addition sites, intron splice sites, or specific mRNA degradation signals). It is perhaps surprising that such misread signals are not a more common feature of heterologous gene expression, but this can be explained in part by the relatively homogeneous A+T content (˜50%) of many organisms. This A+T content plus the nature of the genetic code put clear constraints on the likelihood of occurrence of any particular oligonucleotide sequence. Thus, a gene from E. coli with a 50% A+T content is much less likely to contain any particular A+T rich segment than a gene from B. thuringiensis.

Typically, to obtain high-level expression of the S-endotoxin genes in plants, existing structural coding sequence ("structural gene") which codes for the S-endotoxin are modified by removal of ATTTA sequences and putative polyadenylation signals by site directed mutagenesis of the DNA comprising the structural gene. It is most preferred that substantially all the polyadenylation signals and ATTTA sequences are removed although enhanced expression levels are observed with only partial removal of either of the above identified sequences. Alternately if a synthetic gene is prepared which codes for the expression of the subject protein, codons are selected to avoid the ATTTA sequence and putative polyadenylation signals. For purposes of the present invention putative polyadenylation signals include, but are not necessarily limited to, AATAAA, AATAAT, AACCAA, ATATAA, AATCAA, ATACTA, ATAAAA, ATGAAA, AAGCAT, ATTAAT, ATACAT, AAAATA, ATTAAA, AATTAA, AATACA and CATAAA. In replacing the ATTTA sequences and polyadenylation signals, codons are preferably utilized which avoid the codons which are rarely found in plant genomes.

The selected DNA sequence is scanned to identify regions with greater than four consecutive adenine (A) or thymine (T) nucleotides. The A+T regions are scanned for potential plant polyadenylation signals. Although the absence of five or more consecutive A or T nucleotides eliminates most plant polyadenylation signals, if there are more than one of the minor polyadenylation signals identified within ten, nucleotides of each other, then the nucleotide sequence of this region is preferably altered to remove these signals while maintaining the original encoded amino acid sequence.

The second step is to consider the about 15 to about 30 or so nucleotide residues surrounding the A+T rich region identified in step one. If the A+T content of the surrounding region is less than 80%, the region should be examined for polyadenylation signals. Alteration of the region based on polyadenylation signals is dependent upon (1) the number of polyadenylation signals present and (2) presence of a major plant polyadenylation signal.

The extended region is examined for the presence of plant polyadenylation signals. The polyadenylation signals are removed by site-directed mutagenesis of the DNA sequence. The extended region is also examined for multiple copies of the ATTTA sequence which are also removed by mutagenesis.

It is also preferred that regions comprising many consecutive A+T bases or G+C bases are disrupted since these regions are predicted to have a higher likelihood to form hairpin structure due to self-complementarity. Therefore, insertion of heterogeneous base pairs would reduce the likelihood of self-complementary secondary structure formation which are known to inhibit transcription and/or translation in some organisms. In most cases, the adverse effects may be minimized by using sequences which do not contain more than five consecutive A+T or G+C.

4.11.5 Synthetic Oligonucleotides for Mutagenesis

When oligonucleotides are used in the mutagenesis, it is desirable to maintain the proper amino acid sequence and reading frame, without introducing common restriction sites such as BglII, HindIII, SacI, KpnI, EcoRI, NcoI, PstI and SalI into the modified gene. These restriction sites are found in poly-linker insertion sites of many cloning vectors. Of course, the introduction of new polyadenylation signals, ATTTA sequences or consecutive stretches of more than five A+T or G+C, should also be avoided. The preferred size for the oligonucleotides is about 40 to about 50 bases, but fragments ranging from about 18 to about 100 bases have been utilized. In most cases, a minimum of about 5 to about 8 base pairs of homology to the template DNA on both ends of the synthesized fragment are maintained to insure proper hybridization of the primer to the template. The oligonucleotides should avoid sequences longer than five base pairs A+T or G+C. Codons used in the replacement of wildtype codons should preferably avoid the TA or CG, doublet wherever possible. Codons are selected from a plant preferred codon table (such is Table 6 below) so as to avoid codons which are rarely found in plant genomes, and efforts should be made to select codons to preferably adjust the G+C content to about 50%.

                  TABLE 6                                                          ______________________________________                                         PREFERRED CODON USAGE IN PLANTS                                                                       Percent Usage                                           Amino Acid     Codon   in Plants                                               ______________________________________                                         ARG            CGA     7                                                                      CGC     11                                                                     CGG     5                                                                      CGU     25                                                                     AGA     29                                                                     AGG     23                                                      LEU            CUA     8                                                                      CUC     20                                                                     CUG     10                                                                     CUU     28                                                                     UUA     5                                                                      UUG     30                                                      SER            UCA     14                                                                     UCC     26                                                                     UCG     3                                                                      UCU     21                                                                     AGC     21                                                                     AGU     15                                                      THR            ACA     21                                                                     ACC     41                                                                     ACG     7                                                                      ACU     31                                                      PRO            CCA     45                                                                     CCC     19                                                                     CCG     9                                                                      CCU     26                                                      ALA            GCA     23                                                                     GCC     32                                                                     GCG     3                                                                      GCU     41                                                      GLY            GGA     32                                                                     GGC     20                                                                     GGG     11                                                                     GGU     37                                                      ILE            AUA     12                                                                     AUC     45                                                                     AUU     43                                                      VAL            GUA     9                                                                      GUC     20                                                                     GUG     28                                                                     GUU     43                                                      LYS            AAA     36                                                                     AAG     64                                                      ASN            AAC     72                                                                     AAU     28                                                      GLN            CAA     64                                                                     CAG     36                                                      HIS            CAC     65                                                                     CAU     35                                                      GLU            GAA     48                                                                     GAG     52                                                      ASP            GAC     48                                                                     GAU     52                                                      TYR            UAC     68                                                                     UAU     32                                                      CYS            UGC     78                                                                     UGU     22                                                      PHE            UUC     56                                                                     UUU     44                                                      MET            AUG     100                                                     TRP            UGG     100                                                     ______________________________________                                    

Regions with many consecutive A+T bases or G+C bases are predicted to have a higher likelihood to form hairpin structures due to self-complementarity. Disruption of these regions by the insertion of heterogeneous base pairs is preferred and should reduce the likelihood of the formation of self-complementary secondary structures such as hairpins which are known in some organisms to inhibit transcription (transcriptional terminators) and translation (attenuators).

Alternatively, a completely synthetic gene for a given amino acid sequence can be prepared, with regions of five or more consecutive A+T or G+C nucleotides being avoided. Codons are selected avoiding the TA and CG doublets in codons whenever possible. Codon usage can be normalized against a plant preferred codon usage table (such as Table 6) and the G+C content preferably adjusted to about 50%. The resulting sequence should be examined to ensure that there are minimal putative plant polyadenylation signals and ATTTA sequences. Restriction sites found in commonly used cloning vectors are also preferably avoided. However, placement of several unique restriction sites throughout the gene is useful for analysis of gene expression or construction of gene variants.

4.11.6 "Plantized" Gene Constructs

The expression of a plant gene which exists in double-stranded DNA form involves transcription of messenger RNA (mRNA) from one strand of the DNA by RNA polymerase enzyme, and the subsequent processing of the mRNA primary transcript inside the nucleus. This processing involves a 3' non-translated region which adds polyadenylate nucleotides to the 3' end of the RNA. Transcription of DNA into mRNA is regulated by a region of DNA usually referred to as the "promoter." The promoter region contains a sequence of bases that signals RNA polymerase to associate with the DNA and to initiate the transcription of mRNA using one of the DNA strands as a template to make a corresponding strand of RNA.

A number of promoters which are active in plant cells have been described in the literature. These include the nopaline synthase (NOS) and octopine synthase (OCS) promoters (which are carried on tumor-inducing plasmids of Agrobacterium tumefaciens), the Cauliflower Mosaic Virus (CaMV) 19S and 35S promoters, the light-inducible promoter from the small subunit of ribulose bis-phosphate carboxylase (ssRUBISCO, a very abundant plant polypeptide) and the mannopine synthase (MAS) promoter (Velten et al, 1984 and Velten and Schell, 1985). All of these promoters have been used to create various types of DNA constructs which have been expressed in plants (see e.g., Int. Pat. Appl. Publ. No. WO 84/02913).

Promoters which are known or are found to cause transcription of RNA in plant cells can be used in the present invention. Such promoters may be obtained from plants or plant viruses and include, but are not limited to, the CaMV35S promoter and promoters isolated from plant genes such as ssRUBISCO genes. As described below, it is preferred that the particular promoter selected should be capable of causing sufficient expression to result in the production of an effective amount of protein.

The promoters used in the DNA constructs (i.e. chimeric plant genes) of the present invention may be modified, if desired, to affect their control characteristics. For example, the CaMV35S promoter may be ligated to the portion of the ssRUBISCO gene that represses the expression of ssRUBISCO in the absence of light, to create a promoter which is active in leaves but not in roots. The resulting chimeric promoter may be used as described herein. For purposes of this description, the phrase "CaMV35S" promoter thus includes variations of CaMV35S promoter, e.g, promoters derived by means of ligation with operator regions, random or controlled mutagenesis, etc. Furthermore, the promoters may be altered to contain multiple "enhancer sequences" to assist in elevating gene expression.

The RNA produced by a DNA construct of the present invention also contains a 5' non-translated leader sequence. This sequence can be derived from the promoter selected to express the gene, and can be specifically modified so as to increase translation of the mRNA. The 5' non-translated regions can also be obtained from viral RNA's, from suitable eukaryotic genes, or from a synthetic gene sequence. The present invention is not limited to constructs, as presented in the following examples. Rather, the non-translated leader sequence can be part of the 5' end of the non-translated region of the coding sequence for the virus coat protein, or part of the promoter sequence, or can tie derived from an unrelated promoter or coding sequence. In any case, it is preferred that the sequence flanking the initiation site conform to the translational consensus sequence rules for enhanced translation initiation reported by Kozak (1984).

The cry DNA constructs of the present invention may also contain one or more modified or fully-synthetic structural coding sequences which have been changed to enhance the performance of the cry gene in plants. The structural genes of the present invention may optionally encode a fusion protein comprising an amino-terminal chloroplast transit peptide or secretory signal sequence.

The DNA construct also contains a 3' non-translated region. The 3' nontranslated region contains a polyadenylation signal which functions in plants to cause the addition of polyadenylate nucleotides to the 3' end of the viral RNA. Examples of suitable 3' regions are (1) the 3' transcribed, non-translated regions containing the polyadenylation signal of Agrobacterium tumor-inducing (Ti) plasmid genes, such as the nopaline synthase (NOS) gene, and (2) plant genes like the soybean storage protein (7S) genes and the small subunit of the RuBP carboxylase (E9) gene.

4.12 Methods for Producing Insect-Resistant Transgenic Plants

By transforming a suitable host cell, such as a plant cell, with a recombinant cry* gene-containing segment, the expression of the encoded crystal protein (i.e., a bacterial crystal protein or polypeptide having insecticidal activity against coleopterans) can result in the formation of insect-resistant plants.

By way of example, one may utilize an expression vector containing a coding region for a B. thuringiensis crystal protein and an appropriate selectable marker to transform a suspension of embryonic plant cells, such as wheat or corn cells using a method such as particle bombardment (Maddock et al., 1991; Vasil et al., 1992) to deliver the DNA coated on microprojectiles into the recipient cells. Transgenic plants are then regenerated from transformed embryonic calli that express the insecticidal proteins.

The formation of transgenic plants may also be accomplished using other methods of cell transformation which are known in the art such as Agrobacterium-mediated DNA transfer (Fraley et al., 1983). Alternatively, DNA. can be introduced into plants by direct DNA transfer into pollen (Zhou et al., 1983; Hess, 1987; Luo et al., 1988), by injection of the DNA into reproductive organs of a plant (Pena et al., 1987), or by direct injection of DNA into the cells of immature embryos followed by the rehydration of desiccated embryos (Neuhaus et al., 1987; Benbrook et al., 1986).

The regeneration, development, and cultivation of plants from single plant protoplast transformants or from various transformed explants is well known in the art (Weissbach and Weissbach, 1988). This regeneration and growth process typically includes the steps of selection of transformed cells, culturing those individualized cells through the usual stages of embryonic development through the rooted plantlet stage. Transgenic embryos and seeds are similarly regenerated. The resulting transgenic rooted shoots are thereafter planted in an appropriate plant growth medium such as soil.

The development or regeneration of plants containing the foreign, exogenous gene that encodes a polypeptide of interest introduced by Agrobacterium from leaf explants can be achieved by methods well known in the art such as described (Horsch et al., 1985). In this procedure, transformants are cultured in the presence of a selection agent and in a medium that induces the regeneration of shoots in the plant strain being transformed as described (Fraley et al., 1983 ).

This procedure typically produces shoots within two to four months and those shoots are then transferred to an appropriate root-inducing medium containing the selective agent and an antibiotic to prevent bacterial growth. Shoots that rooted in the presence of the selective agent to form plantlets are then transplanted to soil or other media to allow the production of roots. These procedures vary depending upon the particular plant strain employed, such variations being well known in the art.

Preferably, the regenerated plants are self-pollinated to provide homozygous transgenic plants, as discussed before. Otherwise, pollen obtained from the regenerated plants is crossed to seed-grown plants of agronomically important, preferably inbred lines. Conversely, pollen from plants of those important lines is used to pollinate regenerated plants. A transgenic plant of the present invention containing a desired polypeptide is cultivated using methods well known to one skilled in the art.

Such plants can form germ cells and transmit the transformed trait(s) to progeny plants. Likewise, transgenic plants can be grown in the normal manner and crossed with plants that have the same transformed hereditary factors or other hereditary factors. The resulting hybrid individuals have the corresponding phenotypic properties. A transgenic plant of this invention thus has an increased amount of a coding region (e.g., a mutated cry gene) that encodes the mutated Cry polypeptide of interest. A preferred transgenic plant is an independent segregant and can transmit that gene and its activity to its progeny. A more preferred transgenic plant is homozygous for that gene, and transmits that gene to all of its offspring on sexual mating.

Seed from a transgenic plant may be grown in the field or greenhouse, and resulting sexually mature transgenic plants are self-pollinated to generate true breeding plants. The progeny from these plants become true breeding lines that are evaluated for, by way of example, increased insecticidal capacity against coleopteran insects, preferably in the field, under a range of environmental conditions. The inventors contemplate that the present invention will find particular utility in the creation of transgenic plants of commercial interest including various grasses, grains, fibers, tubers, legumes, ornamental plants, cacti, succulents, fruits, berries, and vegetables, as well as a number of nut- and fruit-bearing trees and plants.

4.13 Methods for Producing Combinatorial Cry3* Variants

Crystal protein mutants containing substitutions in one or more domains may be constructed via a number of techniques. For instance, sequences of highly related genes can be readily shuffled using the PCR™-based technique described by Stemmer (1994). Alternatively, if suitable restriction sites are available, the mutations of one cry gene may be combined with the mutations of a second cry gene by routine subcloning methodologies. If a suitable restriction site is not available, one may be generated by oligonucleotide directed mutagenesis using any number of procedures known to those skilled in the art. Alternatively, splice-overlap extension PCR™ (Horton et al., 1989) may be used to combine mutations in different regions of a crystal protein. In this procedure, overlapping DNA fragments generated by the PCR™ and containing different mutations within their unique sequences may be annealed and used as a template for amplification u:sing flanking primers to generate a hybrid gene sequence. Finally, cry* mutants may be combined by simply using one cry mutant as a template for oligonucleotide-directed mutagenesis using any number of protocols such as those described herein.

4.14 Isolating Homologous Gene and Gene Fragments

The genes and δ-endotoxins according to the subject invention include not only the full length sequences disclosed herein but also fragments of these sequences, or fusion proteins, which retain the characteristic insecticidal activity of the sequences specifically exemplified herein.

It should be apparent to a person skill in this art that insecticidal δ-endotoxins can be identified and obtained through several means. The specific genes, or portions thereof, may be obtained from a culture depository, or constructed synthetically, for example, by use of a gene machine. Variations of these genes may be readily constructed using standard techniques for making point mutations. Also, fragments of these genes can be made using commercially available exonucleases or endonucleases according to standard procedures. For example, enzymes such as Bal31 or site-directed mutagenesis can be used to systematically cut off nucleotides from the ends of these genes. Also, genes which code for active fragments may be obtained using a variety of other restriction enzymes. Proteases may be used to directly obtain active fragments of these δ-endotoxins.

Equivalent δ-endotoxins and/or genes encoding these equivalent δ-endotoxins can also be isolated from Bacillus strains and/or DNA libraries using the teachings provided herein. For example, antibodies to the δ-endotoxins disclosed and claimed herein can be used to identify and isolate other δ-endotoxins from a mixture of proteins. Specifically, antibodies may be raised to the portions of the δ-endotoxins which are most constant and most distinct from other B. thuringiensis δ-endotoxins. These antibodies can then be used to specifically identify equivalent δ-endotoxins with the characteristic insecticidal activity by immunoprecipitation, enzyme linked immunoassay (ELISA), or Western blotting.

A further method for identifying the δ-endotoxins and genes of the subject invention is through the use of oligonucleotide probes. These probes are nucleotide sequences having a detectable label. As is well known in the art, if the probe molecule and nucleic acid sample hybridize by forming a strong bond between the two molecules, it can be reasonably assumed that the probe and sample are essentially identical. The probe's detectable label provides a means for determining in a known manner whether hybridization has occurred. Such a probe analysis provides a rapid method for identifying formicidal δ-endotoxin genes of the subject invention.

The nucleotide segments which are used as probes according to the invention can be synthesized by use of DNA synthesizers using standard procedures. In the use of the nucleotide segments as probes, the particular probe is labeled with any suitable label known to those skilled in the art, including radioactive and non-radioactive labels. Typical radioactive labels include ³² P, ¹²⁵ I, ³⁵ S, or the like. A probe labeled with a radioactive isotope can be constructed from a nucleotide sequence complementary to the DNA sample by a conventional nick translation reaction, using a DNase and DNA polymerase. The probe and sample can then be combined in a hybridization buffer solution and held at an appropriate temperature until annealing occurs. Thereafter, the membrane is washed free of extraneous materials, leaving the sample and bound probe molecules typically detected and quantified by autoradiography and/or liquid scintillation counting.

Non-radioactive labels include, for example, ligands such as biotin or thyroxine, as well as enzymes such as hydrolases or peroxidases, or the various chemiluminescers such as luciferin, or fluorescent compounds like fluorescein and its derivatives. The probe may also be labeled at both ends with different types of labels for ease of separation, as, for example, by using an isotopic label at the end mentioned above and a biotin label at the other end.

Duplex formation and stability depend on substantial complementarity between the two strands of a hybrid, and, as noted above, a certain degree of mismatch can be tolerated. Therefore, the probes of the subject invention include mutations (both single and multiple), deletions, insertions of the described sequences, and combinations thereof, wherein said mutations, insertions and deletions permit formation of stable hybrids with the target polynucleotide of interest. Mutations, insertions, and deletions can be produced in a given polynucleotide sequence in many ways, by methods currently known to an ordinarily skilled artisan, and perhaps by other methods which may become known in the future.

The potential variations in the probes listed is due, in part, to the redundancy of the genetic code. Because of the redundancy of the genetic code, i.e., more than one coding nucleotide triplet (codon) can be used for most of the amino acids used to make proteins. Therefore different nucleotide sequences can code for a particular amino acid. Thus, the amino acid sequences of the B. thuringiensis δ-endotoxins and peptides can be prepared by equivalent nucleotide sequences encoding the same amino acid sequence of the protein or peptide. Accordingly, the subject invention includes such equivalent nucleotide sequences. Also, inverse or complement sequences are an aspect of the subject invention and can be readily used by a person skilled in this art. In addition it has been shown that proteins of identified structure and function may be constructed by changing the amino acid sequence if such changes do not alter the protein secondary structure (Kaiser and Kezdy, 1984). Thus, the subject invention includes mutants of the amino acid sequence depicted herein which do not alter the protein secondary structure, or if the structure is altered, the biological activity is substantially retained. Further, the invention also includes mutants of organisms hosting all or part of a δ-endotoxin encoding a gene of the invention. Such mutants can be made by techniques well known to persons skilled in the art. For example, UV irradiation can be used to prepare mutants of host organisms. Likewise, such mutants may include asporogenous host cells which also can be prepared by procedures well known in the art.

4.15 Ribozymes

Ribozymes are enzymatic RNA molecules which cleave particular mRNA species. In certain embodiments, the inventors contemplate the selection and utilization of ribozymes capable of cleaving the RNA segments of the present invention, and their use to reduce activity of target mRNAs in particular cell types or tissues.

Six basic varieties of naturally-occurring enzymatic RNAs are known presently. Each can catalyze the hydrolysis of RNA phosphodiester bonds in trans (and thus can cleave other RNA molecules) under physiological conditions. In general enzymatic nucleic acids act by first binding to a target RNA. Such binding occurs through the target binding portion of a enzymatic nucleic acid which is held in close proximity to an enzymatic portion of the molecule that acts to cleave the target RNA. Thus, the enzymatic nucleic acid first recognizes and then binds a target RNA through complementary base-pairing, and once bound to the correct site, acts enzymatically to cut the target RNA. Strategic cleavage of such a target RNA will destroy its ability to direct synthesis of an encoded protein. After an enzymatic nucleic acid has bound and cleaved its RNA target, it is released from that RNA to search for another target and can repeatedly bind and cleave new targets.

The enzymatic nature of a ribozyme is advantageous over many technologies, such as antisense technology (where a nucleic acid molecule simply binds to a nucleic acid target to block its translation) since the concentration of ribozyme necessary to affect a therapeutic treatment is lower than that of an antisense oligonucleotide. This advantage reflects the ability of the ribozyme to act enzymatically. Thus, a single ribozyme molecule is able to cleave many molecules of target RNA. In addition, the ribozyme is a highly specific inhibitor, with the specificity of inhibition depending not only on the base pairing mechanism of binding to the target RNA, but also on the mechanism of target RNA cleavage. Single mismatches, or base-substitutions, near the site of cleavage can completely eliminate catalytic activity of a ribozyme. Similar mismatches in antisense molecules do not prevent their action (Woolf et al., 1992). Thus, the specificity of action of a ribozyme is greater than that of an antisense oligonucleotide binding the same RNA site.

The enzymatic nucleic acid molecule may be formed in a hammerhead, hairpin, a hepatitis δ virus, group I intron or RNaseP RNA (in association with an RNA guide sequence) or Neurospora VS RNA motif. Examples of hammerhead motifs are described by Rossi et al. (1 992); examples of hairpin motifs are described by Hampel et al. (Eur. Pat. EP 0360257), Hampel and Tritz (1989), Hampel et a. (1990) and Cech et al. (U.S. Pat. No. 5,631,359; an example of the hepatitis δ virus motif is described by Perrotta and Been (1992); an example of the RNaseP motif is described by Guerrier-Takada et al. (1983); Neurospora VS RNA ribozyme motif is described by Collins (Saville and Collins, 1990; Saville and Collins, 1991; Collins and Olive, 1993); and an example of the Group I intron is described by Cech et al. (U.S. Pat. No. 4,987,071). All that is important in an enzymatic nucleic acid molecule of this invention is that it has a specific substrate binding site which is complementary to one or more of the target gene RNP, regions, and that it have nucleotide sequences within or surrounding that substrate binding site which impart an RNA cleaving activity to the molecule. Thus the ribozyme constructs need not be limited to specific motifs mentioned herein.

The invention provides a method for producing a class of enzymatic cleaving agents which exhibit a high degree of specificity for the RNA of a desired target. The enzymatic nucleic acid molecule is preferably targeted to a highly conserved sequence region of a target mRNA such that specific treatment of a disease or condition can be provided with either one or several enzymatic nucleic acids. Such enzymatic nucleic acid molecules can be delivered exogenously to specific cells as required. Alternatively, the ribozymes can be expressed from DNA or RNA vectors that are delivered to specific cells.

Small enzymatic nucleic acid motifs (e.g., of the hammerhead or the hairpin structure) may be used for exogenous delivery. The simple structure of these molecules increases the ability of the enzymatic nucleic acid to invade targeted regions of the mRNA structure. Alternatively, catalytic RNA molecules can be expressed within cells from eukaryotic promoters (e.g., Scanlon et al., 1991; Kashani-Sabet et al., 1992; Dropulic et al., 1992; Weerasinghe et al., 1991; Ojwang et al., 1992; Chen et al., 1992; Sarver et al., 1990). Those skilled in the art realize that any ribozyme can be expressed in eukaryotic cells from the appropriate DNA vector. The activity of such ribozymes can be augmented by their release from the primary transcript by a second ribozyme (Draper et al., Int. Pat. Appl. Publ. No. WO 93/23569, and Sullivan el al., Int. Pat. Appl. Publ. No. WO 94/02595, both hereby incorporated in their totality by reference herein; Ohkawa et al., 1992; Taira et al., 1991; Ventura et al., 1993).

Ribozymes may be added directly, or can be complexed with cationic lipids, lipid complexes, packaged within liposomes, or otherwise delivered to target cells. The RNA or RNA complexes can be locally administered to relevant tissues ex vivo, or in vivo through injection, aerosol inhalation, infusion pump or sterit, with or without their incorporation in biopolymers.

Ribozymes may be designed as described in Draper et al. (Int. Pat. Appl. Publ. No. WO 93/23569), or Sullivan et al., (Int. Pat. Appl. Publ. No. WO 94/02595) and synthesized to be tested in vitro and in vivo, as described. Such ribozymes can also be optimized for delivery. While specific examples are provided, those in the art will recognize that equivalent RNA targets in other species can be utilized when necessary.

Hammerhead or hairpin ribozymes may be individually analyzed by computer folding (Jaeger et al., 1989) to assess whether the ribozyme sequences fold into the appropriate secondary structure. Those ribozymes with unfavorable intramolecular interactions between the binding arms and the catalytic core are eliminated from consideration. Varying binding arm lengths can be chosen to optimize activity. Generally, at least 5 bases on each arm are able to bind to, or otherwise interact with, the target RNA.

Ribozymes of the hammerhead or hairpin motif may be designed to anneal to various sites in the mRNA message, and can be chemically synthesized. The method of synthesis used follows the procedure for normal RNAk synthesis as described in Usman et al. (1987) and in Scaringe et al. (1990) and makes use of common nucleic acid protecting and coupling groups, such as dimethoxytrityl at the 5'-end, and phosphoramidites at the 3'-end. Average stepwise coupling yields are typically >98%. Hairpin ribozymes may be synthesized in two parts and annealed to reconstruct an active ribozyme (Chowrira and Burke, 1992). Ribozymes may be modified extensively to enhance stability by modification with nuclease resistant groups, for example, 2'-amino, 2'-C-allyl, 2'-flouro, 2'-o-methyl, 2'-H (for a review see Usman and Cedergren, 1992). Ribozymes may be purified by gel electrophoresis using general methods or by high pressure liquid chromatography and resuspended in water.

Ribozyme activity can be optimized by altering the length of the ribozyme binding arms, or chemically synthesizing ribozymes with modifications that prevent their degradation by serum ribonucleases (see e.g., Int. Pat. Appl. Publ. No. WO 92/07065; Perrault et al, 1990; Pieken et al., 1991; Usman and Cedergren, 1992; Int. Pat. Appl. Publ. No. WO 93/15187; Int. Pat. Appl. Publ. No. WO 91/03162; Eur. Pat. Appl. Publ. No. 92110298.4; U.S. Pat. No. 5,334,711; and Int. Pat. Appl. Publ. No. WO 94/13688, which describe various chemical modifications that can be made to the sugar moieties of enzymatic RNA molecules), modifications which enhance their efficacy in cells, and removal of stem II bases to shorten RNA synthesis times and reduce chemical requirements.

Sullivan et al (Int. Pat. Appl. Publ. No. WO 94/02595) describes the general methods for delivery of enzymatic RNA molecules. Ribozymes may be administered to cells by a variety of methods known to those familiar to the art, including, but not restricted to, encapsulation in liposomes, by iontophoresis, or by incorporation into other vehicles, such as hydrogels, cyclodextrins, biodegradable nanocapsules, and bioadhesive microspheres. For some indications, ribozymes may be directly delivered ex vivo to cells or tissues with or without the aforementioned vehicles. Alternatively, the RNA/vehicle combination may be locally delivered by direct inhalation, by direct injection or by use of a catheter, infusion pump or stent. Other routes of delivery include, but are not limited to, intravascular, intramuscular, subcutaneous or joint injection, aerosol inhalation, oral (tablet or pill form), topical, systemic, ocular, intraperitoneal and/or intrathecal delivery. More detailed descriptions of ribozyme delivery and administration are provided in Sullivan et al. (Int. Pat. Appl. Publ. No. WO 94/02595) and Draper et al (Int. Pat. Appl. Publ. No. WO 93/23569) which have been incorporated by reference herein.

Another means of accumulating high concentrations of a ribozyme(s) within cells is to incorporate the ribozyme-encoding sequences into a DNA expression vector. Transcription of the ribozyme sequences are driven from a promoter for eukaryotic RNA polymerase I (pol I), RNA polymerase II (pol II), or RNA polymerase III (pol III). Transcripts from pol I or pol III promoters will be expressed at high levels in all cells; the levels of a given pol II promoter in a given cell type will depend on the nature of the gene regulatory sequences (enhancers, silencers, etc.) present nearby. Prokaryotic RNA polymerase promoters may also be used, providing that the prokaryotic RNA polymerase enzyme is expressed in the appropriate cells (Elroy-Stein and Moss, 1990; Gao and Huang, 1993; Lieber et al., 1993; Zhou et al., 1990). Ribozymes expressed from such promoters can function in mammalian cells (e.g. Kashani-Saber et al., 1992; Ojwang et al., 1992; Chen et al., 1992; Yu et al., 1993; L'Huillier et al., 1992; Lisziewicz et al., 1993;). Such transcription units can be incorporated into a variety of vectors for introduction into mammalian cells, including but not restricted to, plasmid DNA vectors, viral DNA vector, (such as adenovirus or adeno-associated vectors), or viral RNA vectors (such as retroviral, semliki forest virus, sindbis virus vectors).

Ribozymes of this invention may be used as diagnostic tools to examine genetic drift and mutations within cell lines or cell types. They can also be used to assess levels of the target RNA molecule. The close relationship between ribozyme activity and the structure of the target RNA allows the detection of mutations in any region of the molecule which alters the base-pairing and three-dimensional structure of the target RNA. By using multiple ribozymes described in this invention, one may map nucleotide changes which are important to RNA structure and function in vitro, as well as in cells and tissues. Cleavage of target RNAs with ribozymes may be used to inhibit gene expression and define the role (essentially) of specified gene products in particular cells or cell types.

5.0 EXAMPLES

The following examples are included to demonstrate preferred embodiments of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventor to function well in the practice of the invention, and thus can be considered to constitute preferred modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.

5.1 Example 1

Three-Dimensional Structure of Cry3Bb

The three-dimensional structure of Cry3Bb was determined by X-ray crystallography. Crystallization of Cry3Bb and X-ray diffraction data collection were performed as described by Cody et al. (1992). The crystal structure of Cry3Bb was refined to a residual R factor of 18.0% using data collected to 2.4 Å resolution. The crystals belong to the space group C222₁ with unit cell dimensions a=122.44, b=131.81, and c=105.37 Å and contain one molecule in the asymmetric unit. Atomic coordinates for Cry3Bb are described in Example 31 and listed in Section 9.

The structure of Cry3Bb is similar to that of Cry3A (Li et al., 1991). It consists of 5825 protein atoms from 588 residues (amino acids 64-652) forming three discrete domains (FIG. 1). A total of 251 water molecules have been identified in the Cry3Bb structure (FIG. 2). Domain 1 (residues 64-294) is a seven helical bundle formed by six helices twisted around the central helix, α5 (FIG. 3). The amino acids forming each helix are listed in FIG. 4. Domain 2 (residues 295-502) contains three antiparallel β-sheets (FIG. 5A and FIG. 5B). Sheets 1 and 2, each composed of 4β strands, form the distinctive "Greek key" motif. The outer surface of sheet 3, composed of 3β strands, makes contact with helix α7 of domain 1. FIG. 6 lists the amino acids comprising each β strand in domain 2. A small α helix, α8 which follows β strand 1, is also included in domain 2. Domain 3 (residues 503-652) has a "jelly roll" β-barrel topology which has a hydrophobic core and is nearly parallel to the a and perpendicular to the c axes of the lattice (FIG. 7A and FIG. 7B). The amino acids comprising each β strand of domain 3 are listed in FIG. 8.

The monomers of Cry3Bb in the crystal form a dimeric quaternary structure along a two-fold axis parallel to the a axis (FIG. 9A and FIG. 9B). Helix α6 lies in a cleft formed by the interface of domain 1 and domains 1 and 3 of its symmetry related molecule. There are numerous close hydrogen bonding contacts along this surface, confirming the structural stability of the dimer.

5.2 Example 2

Preparation of Cry3Bb.60

B. thuringiensis EG7231 was grown through sporulation in C2 medium with chloramphenicol (Cml) selection. The solids from this culture were recovered by centrifugation and washed with water. The toxin was purified by recrystallization from 4.0 M NaBr (Cody et al, 1992). The purified Cry3Bb was solubilized in 10 ml of 50mM KOH/100 mg Cry3Bb and buffered to pH 9.0 with 100 mM CAPS (pH 9.0). The soluble toxin was treated with trypsin at a weight ratio of 50 mg toxin to 1 mg trypsin. After 20 min of trypsin digestion the predominant protein visualized by SDS-polyacrylamide gel electrophoresis (SDS-PAGE) was 60 kDa. Further digestion of the 60-kDa toxin was not observed. FIG. 4 illustrates the Coomassie-stained Cry3Bb and Cry3Bb.60 following SDS-PAGE.

5.3 Example 3

Purification and Sequencing of Cry3Bb.60

Cry3Bb.60 was electrophoretically purified by SDS-PAGE and electroblotted to Immobilon-® (Millipore) membrane by semi-dry transfer at 15V for 30 min. The membrane was then washed twice with water and stained with 0.025% R-250, 40% methanol. To reduce the background, the blot was destained with 50% methanol until the stained protein bands were visible. The blot was then air dried, and the stained Cry3Bb.60 band was cut out of the membrane. This band was sent to the Tufts University Sequencing Laboratory (Boston, Mass.) for N-terminal sequencing. The experimentally-determined N-terminal amino acid sequence is shown in Table 7 beside the known amino acid sequence starting at amino acid residue 160.

                  TABLE 7                                                          ______________________________________                                         AMINO ACID SEQUENCE OF THE N-TERMINUS OF CRY3BB.60                             AND COMPARISON TO THE KNOWN SEQUENCE OF CRY3BB                                 Deduced Sequence                                                                               Known Sequence                                                                             Residue #                                          ______________________________________                                         S               S           160                                                K               K           161                                                R               R           162                                                S               S           163                                                Q               Q           164                                                D               D           165                                                R               R           166                                                ______________________________________                                    

5.4 Example 4

Bioactivity of Cry3Bb.60

Cry3Bb was prepared for bioassay by solubilization in a minimal amount of 50 mM KOH, 10 ml per 100 mg toxin, and buffered to pH 9.0 with 100 mM CAPS, pH 9.0. Cry3Bb.60 was prepared as described in Example 1. Both preparations were kept at room temperature 12 to 16 hours prior to bioassay. After seven days the mortality of the population was determined and analyzed to determine the lethal concentration of each toxin. These results are numerized in Table 8.

                  TABLE 8                                                          ______________________________________                                         BIOACTIVITY OF CRY3BB AND CRY3BB.60 AGAINST THE                                SOUTHERN CORN ROOTWORM                                                         (DIABIOTICA UNDECIMPUNCTATA)                                                                LC.sub.50 mg/well                                                                       95% C. I.                                                ______________________________________                                         Cry3Bb         24.09      15-39                                                Cry3Bb.60      6.72       5.25-8.4                                             ______________________________________                                    

5.5 Example 5

Ion-Channel Formation by Cry3Bb and CRYB2.60

Cry3Bb.60 and Cry3Bb were evaluated for their ability to form ion channels in planar lipid bilayers. Bilayers of phosphatidylcholine were formed on Teflon® supports over a 0.7-mm hole. A bathing solution of 3.5 ml 100 mM KOH, 10 mM CaCl₂, 100 mM CAPS (pH 9.5) was placed on either side of the Teflon® partition. The toxin was added to one side of the partition and a voltage of 60 mV was imposed across the phosphatidylcholine bilayer. Any leakage of ions through the membrane was amplified and recorded. An analysis of the frequency of the conductances created by either Cry3Bb or Cry3Bb.60 are illustrated in FIG. 5A and FIG. 5B. Cry3Bb.60 readily formed ion channels whereas Cry3Bb rarely formed channels.

5.6 Example 6

Formation of High Molecular-Weight Oligomers

Individual molecules of Cry3Bb or Cry3Bb.60 form a complex with another like molecule. The ability of Cry3Bb to form an oligomer is not reproducibly apparent. The complex cannot be repeatedly observed to form under nondenaturing conditions. Cry3Bb.60 formed a significantly greater amount of a higher molecular-weight complex (≧120 kDa) with other Cry3Bb.60 molecules. Oligomers of Cry3Bb are demonstrated by the intensity of the Coomassie-stained SDS polyacrylamide gel. Oligomerization is visualized on SDS-PAGE by not heating samples prior to loading on the gel to retain some nondenatured toxin. These data suggest that Cry3Bb.60 more readily forms the higher order complex than Cry3Bb alone. Oligomerization is also observed by studying the conductance produced by these molecules and the time-dependent increase in conductance. This change in conductance can be attributed to oligomerization of the toxin.

5.7 Example 7

Design Method 1: Identification and Alteration of Protease-Sensitive Sites and Proteolytic Processing

It has been reported in the literature that: treatment of Cry3A toxin protein with trypsin, an enzyme that cleaves proteins on the carboxyl side of available lysine and arginine residues, yields a stable cleavage product of 55 kDa from the 67 kDa native protein (Carroll et al., 1989). N-terminal sequencing of the 55 kDa product showed cleavage occurs at amino acid residue R158. The truncated Cry3A protein was found to retain the same level of insecticidal activity as the native protein. Cry3Bb toxin protein was also treated with trypsin. After digestion, the protein size decreased from 68 kDa, the molecular weight of the native Cry3Bb toxin, to 60 kDa. No further digestion was observed. N-terminal sequencing revealed the trypsin cleavage site of the truncated toxin (Cry3Bb.60) to be amino acid R159 in lα3,4 of Cry3Bb. Unexpectedly, the bioactivity of the truncated Cry3Bb toxin was found to increase.

Using this method, protease digestion of a B. thuringiensis toxin protein, a proteolytically sensitive site was identified on Cry3Bb, and a more highly active form of the protein (Cry3Bb.60) was identified. Modifications to this proteolytically-sensitive site by introducing an additional protease recognition site also resulted in the isolation of a biologically more active protein. It is also possible that removal of other protease-sensitive site(s) may improve activity. Proteolytically sensitive regions, once identified, may be modified or utilized to produce biologically more active toxins.

5.7.1 Cry3Bb.60

Treatment of solubilized Cry3Bb toxin protein with trypsin results in the isolation of a stable, truncated Cry3Bb toxin protein with a molecular weight of 60 kDa (Cry3Bb.60). N-terminal sequencing of Cry3Bb.60 shows the trypsin-sensitive site to be R159 in lα3,4 of the native toxin. Trypsin digestion results in the removal of helices 1-3 from the native Cry3Bb but also increases the activity of the toxin against SCRW larvae approximately four-fold.

Cry3Bb.60 is a unique toxin with enhanced insecticidal use over the parent Cry3Bb. Improved biological activity, is only one parameter that distinguishes it as a new toxin. Aside from the reduced size, Cry3Bb.60 is also a more soluble protein. Cry3Bb precipitates from solution at pH 6.5 while Cry3Bb.60 remains in solution from pH 4.5 to pH 12. Cry3Bb.60 also forms ion channels with greater frequency than Cry3Bb.

Cry3Bb.60 is produced by either the proteolytic removal of the first 159 amino acid residues, or the in vivo production of this toxin, by bacteria or plants expressing the gene for Cry3Bb.60, that is, the Cry3Bb gene without the first 483 nucleotides.

In conclusion, Cry3Bb.60 is distinct from Cry3Bb in several important ways: enhanced insecticidal activity; enhanced range of solubility; enhanced ability to form channels; and reduced size.

5.7.2 EG11221

Semi-random mutagenesis of the trypsin-sensitive lα3,4 region of Cry3Bb resulted in the isolation of Cry3Bb.11221, a designed Cry3Bb protein that exhibits over a 6-fold increase in activity against SCRW larvae compared to WT. Cry3Bb.11221 has 4 amino acid changes in the lα3,4 region. One of these changes, L158R, introduces an additional trypsin site adjacent to R159, the proteolytically sensitive site used to produce Cry3Bb.60 (example 4.1.1). Cry3Bb.11221 is produced by B. thuringiensis as a full length toxin protein but is presumably digested by insect gut proteases to the same size as Cry3Bb.60 (see Cry3A results from Carroll et al., 1989). The additional protease recognition site may make the lα3,4 region even more sensitive to digestion, thereby increasing activity.

5.8 Example 8

Design Method 2: Determination and Manipulation of Bound Water

There are several ways that water molecules can associate with a protein, including surface water that is easily removed and bound water that is more difficult to extract (Dunitz, 1994; Zhang and Matthews, 1994). The function of bound water has been the subject of significant academic extrapolation, but the precise function has little experimental validation. Some of the most interesting bound or structural water is the water that participates in the protein structure from inside the protein itself.

The occupation of a site by a water molecule can indicate a stable pocket within a protein or a looseness of packing created by water-mediated salt bridges and hydrogen bonding to water. This can reduce the degree of bonding between amino acids, possibly making the region more flexible. A different amino acid sequence around that same site could result in better packing, collapsing the pocket around polar or charged amino acids. This may result in decreased flexibility. Therefore, the degree of hydration of a region of a protein may determine the flexibility or mobility of that region, and manipulation of the hydration may alter the flexibility. Methods of increasing the hydration of a water-exposed region include increasing the number of hydrophobic residues along that surface. It is taught in the art that exposed hydrophobic residues require significantly more water to hydrate than hydrophilic residues (CRC Handbook of Chemistry and Physics, CRC Press, Inc.). It is not taught, however, that by doing this, improvements to the biological activity of a protein can be achieved.

Structural water has not previously been identified in B. thuringiensis δ-endotoxins including Cry3Bb. Furthermore, there are no reports of the function of this structural water in δ-endotoxins or bacterial toxins. In the analysis of Cry3Bb, it was observed that a collection of water molecules are located around lα3,4, a site defined by the inventors as important for improvement of bioactivity. The loop α3,4 region is surface exposed and may define a hinge in the protein permitting either removal or movement of the first three helices of domain 1. The hydration found around this region may impart flexibility and mobility to this loop. The observation of structural water at the lα3,4 site provided an analytical tool for further structure analysis. If this important site is surrounded by water, then other important sites may also be completely or partially surrounded by water. Using this insight, structural water surrounding helices 5 and 6 was then identified. This structural water forms a column through the protein, effectively separating helices 5 and 6 from the rest of the molecule. The structures of Cry3A and Cry3Bb suggest that helices 5 and 6 are tightly associated, bound together by Van der Waals interactions. Alone, helix 5 from Cry3A, although insufficient for biological activity, has been demonstrated to have the ability to form ion channels in an artificial membrane (Gazit and Shai, 1993). The ion channels formed by helix 5 are 10-fold smaller than the channels of the full length toxin suggesting that significantly more toxin structure is required for the full-sized ion channels. In Cry3Bb, helix 5 as part of a cluster of α helices (domain 1) has been found to form ion channels (Von Tersch et al., 1994). Unpublished experimental observations by the inventors demonstrate that helix 6 also crossed the biological membrane. Helices 5 and 6, therefore, are the putative channel-forming helices necessary for toxicity.

The hydration around these helices may indicate that flexibility of this region is necessary for toxicity. It is conceivable, therefore, that if it were possible to improve the hydration around helices 5 and 6, one could create a better toxin protein. Care must be taken, however, to avoid creating continuous hydrophobic surfaces between helices 5-6 and any other part of the protein which could, by hydrophobic interactions, act to restrict movement of the mobile helices. The mobility of helices 5 and 6 may also depend on the flexibility of the loops attached to them as well as on other regions of the Cry3Bb molecule, particularly in domain 1, which may undergo conformational changes to allow insertion of the 2 helices into the membrane. Altering the hydration of these regions of the protein may also affect its bioactivity.

5.8.1 Cry3Bb.11032

A collection of bound water residues indicated the relative flexibility of the lα3,4 region. The flexibility of this loop can be increased by increasing the hydration of the region by substituting relatively hydrophobic residues for the exposed hydrophilic residues. An example of an improved, designed protein having this type of substitution is Cry3Bb.11032. Cry3Bb.11032 has the amino acid change D165G; glycine is more hydrophobic than aspartate (Kyte and Doolittle hydrophobicity score of -0.4 vs. -3.5 for aspartate). Cry3Bb.11032 is approximately 3 times more active than WT Cry3Bb.

5.8.2 Cry3Bb.11051

To increase the hydration of the lα4,5 region of Cry3Bb, glycine was substituted for the surface exposed residue K189. Glycine is more hydrophobic than lysine (Kyte and Doolittle hydrophobicity score of -0.4 vs. -3.9 for lysine) and may result in an increase in bound water. The increase in bound water may impart greater flexibility to the loop region which precedes the channel-forming helix, α5. The designed Cry3Bb protein with the K189G change, Cry3Bb.11051, exhibits a 3-fold increase in activity compared to WT Cry3Bb.

5.8.3 Alterations to lα7,β1 (Cry3Bb.11241 and 11242)

Amino acid changes made in the surface-exposed loop connecting α-helix 7 and β-strand 1 (lα7,β1) resulted in the identification of 2 altered Cry3Bb proteins with increased bioactivities, Cry3Bb.11241 and Cry3Bb.11242. Analysis of the hydropathy index of 2 of these proteins over the 20 amino acid sequence 281-300, inclusive of the lα7,β1 region, reveal that the amino acid substitutions in these proteins have made the lα7,β1 region much more hydrophobic. The grand average of hydropathy value (GRAVY) was determined for each protein sequence using the PC\GENE® (IntelliGenetics, Inc., Mountain View, Calif., release 6.85) protein sequence analysis computer program, SOAP, and a 7 amino acid interval. The SOAP program is based on the method of Kyte and Doolittle (1982). The increase in hydrophobicity of the lα7,β1 region for each protein may increase the hydration of the loop and, therefore, the flexibility. The altered proteins, their respective amino acid changes, fold-increases over WT bioactivity, and GRAVY values are listed in Table 9.

                                      TABLE 9                                      __________________________________________________________________________     HYDROPATHY VALUES FOR THE Lα7,β1 REGION OF CRY3BB AND 2             DESIGNED CRY3BB PROTEINS SHOWING INCREASED SCRW BIOACTIVITY                                        Fold Increase in                                                                        GRAVY                                             Cry3Bb*             Bioactivity Over                                                                        (Amino Acids 281-                                 Protein Amino Acid Changes                                                                         WT       300)                                              __________________________________________________________________________     wildtype                                                                               --          --       4.50                                              Cry3Bb.11241                                                                           Y287F, D288N, R290L                                                                        2.6x     10.70                                             Cry3Bb.11242                                                                           R290V       2.5x     8.85                                              __________________________________________________________________________

5.8.4 Alterations to lβ1,α8 (Cry3Bb.11228, Cry3Bb.11229, Cry3Bb.11230, Cry3Bb.11233, Cry3Bb.11236, Cry3Bb.11237, Cry3Bb.11238 and Cry3Bb.11239)

The surface-exposed loop between β-strand 1 and α-helix 8 (lβ1,α8) defines the boundary between domains 1 and 2 of Cry3Bb. The introduction of semi-random amino acid changes to this region resulted in the identification of several altered Cry3Bb proteins with increased bioactivity. Hydropathy index analysis of the amino acid substitutions found in the altered proteins shows that the changes have made the exposed region more hydrophobic which may result in increased hydration and flexibility. Table 10 lists the altered proteins, their respective amino acid changes and fold increases over WT Cry3Bb and the grand average of hydropathy value (GRAVY) determined using the PC\GENE® (IntelliGenetics, Inc., Mountain View, Calif., release 6.85) protein sequence analysis program, SOAP, over the 20 amino acid sequence 305-324 inclusive of lβ1,α8, using a 7 amino acid interval.

                  TABLE 10                                                         ______________________________________                                         HYDROPATHY VALUES FOR THE Lβ1,α8 REGION                             OF CRY3BB AND 8 DESIGNED CRY3BB*                                               PROTEINS SHOWING INCREASED SCRW BIOACTIVITY                                                          Fold Increase in                                                                           GRAVY                                        Cry3Bb*   Amino Acid  Bioactivity Over                                                                           (Amino Acids                                 Protein   Changes     Wild Type   305-324)                                     ______________________________________                                         wildtype  --          --          0.85                                         Cry3Bb.11228                                                                             S311L, N313T,                                                                              4.1×  4.35                                                   E317K                                                                Cry3Bb.11229                                                                             S311T, E317K,                                                                              2.5×  2.60                                                   Y318C                                                                Cry3Bb.11230                                                                             S311A, L312V,                                                                              4.7×  3.65                                                   Q316W                                                                Cry3Bb.11233                                                                             S311A, Q316D                                                                               2.2×  2.15                                         Cry3Bb.11236                                                                             S311I       3.1×  3.50                                         Cry3Bb.11237                                                                             S311I, N313H                                                                               5.4×  3.65                                         Cry3Bb.11238                                                                             N313V, T314N,                                                                              2.6×  9.85                                                   Q316M, E317V                                                         Cry3Bb.11239                                                                             N313R, L315P,                                                                              2.8×  3.95                                                   Q316L, E317A                                                         ______________________________________                                    

5.8.5 Cry3Bb.11227, Cry3Bb.11241 and Cry3Bb.11242

Amino acid Q238, located in helix 6 of Cry3Bb, has been identified as a residue that, by its large size and hydrogen bonding to R290, blocks complete hydration of the space between helix 6 and helix 4. Substitution of R290 with amino acids that do not form hydrogen bonds or that have side chains that can not span the physical distance to hydrogen bond with Q238 may result in increased hydration around Q238. Q238, unable to hydrogen bond to R-290, may now bind water. This may increase the flexibility of the channel-forming region. Designed proteins Cry3Bb.11227 (R290N), Cry3Bb.11241 (R290L) and Cry3Bb.11242 (R290V) show increased activities of approximately 2-fold, 2.6-fold and 2.5-fold, respectively, against SCRW larvae compared to WT.

5.9 Example 9

Design Method 3: Manipulation of Hydrogen Bonds Around Mobile Regions

Mobility of regions of a protein may be required for activity. The mobility of the α5,6 region, the putative channel-forming region of Cry3Bb, may be improved by decreasing the number of hydrogen bonds, including salt bridges (hydrogen bonds between oppositely charged amino acid side chains), between helices 5-6 and any other part of the molecule or dimer structure. These hydrogen bonds may impede the movement of the two helices. Decreasing the number of hydrogen bonds and salt bridges may improve biological activity. Replacement of hydrogen-bonding amino acids with hydrophobic residues must be done with caution to avoid creating continuous hydrophobic surfaces between helices 5-6 and any other part of the dimer. This may decrease mobility by increasing hydrophobic surface interactions.

5.9.1 Cry3Bb.11222 and Cry3Bb.11223

Tyr230 is located on helix 6 and, in the quaternary dimer structure of Cry3Bb, this amino acid is coordinated with Tyr230 from the adjacent molecule. Three hydrogen bonds are formed between the two helices 6 in the two monomers because of this single amino acid. In order to improve the flexibility of helices 5-6, the helices theoretically capable of penetrating the membrane and forming an ion channel, the hydrogen bonds across the dimer were removed by changing this amino acid and a corresponding increase in biological activity was observed. The designed Cry3Bb proteins, Cry3Bb.11222 and Cry3Bb.EG11223, show a 4-fold and 2.8-fold increase in SCRW activity, respectively, compared to WT.

5.9.2 Cry3Bb.11051

Designed Cry3Bb protein Cry3Bb.11051 has amino acid change K189G in lα4,5 of domain 1. In the WT Cry3Bb structure, the exposed side chain of K189 is close enough to the exposed side change of E123, located in lα2b,3, to form hydrogen bonds. Substitution of K189 with glycine, as found in this position in Cry3A, removes the possibility of hydrogen bond formation at this site and results in a protein with a bioactivity three-fold greater than WT Cry3Bb.

5.9.3 Cry3Bb.11227, Cry3Bb.11241 and Cry3Bb.11242

Amino acid Q238, located in helix 6 of Cry3Bb, has been identified as a residue that, by its large size and hydrogen bonding to R290, blocks complete hydration of the space between helix 6 and helix 4. Substitution of R290 with amino acids that do not form hydrogen bonds or that have side chains that can not span the physical distance to hydrogen bond with Q238 may increase the flexibility of the channel-forming region. Designed proteins Cry3Bb.11227 (R290N), Cry3Bb.11241 (R290L) and Cry3Bb.11242 (R290V) show increased activities of approximately 2-fold, 2.6-fold and 2.5-fold, respectively, against SCRW larvae compared to WT

5.10 Example 10

Design Method 4: Loop Analysis and Loop Design Around Flexible Helices

Loop regions of a protein structure may be involved in numerous functions of the protein including, but not limited to, channel formation, quaternary structure formation and maintenance, and receptor binding. Cry3Bb is a channel-forming protein. The availability of the ion channel-forming helices of δ-endotoxins to move into the bilayer depend upon the absence of forces that hinder the process. One of the forces possibly limiting this process is the steric hindrance of amino acid side chains in loop) regions around the critical helices. The literature suggests that in at least one other bacterial toxin, not a B. thuringiensis toxin, the toxin molecule opens up or, in scientific terms, loses some of the quaternary structure to expose a membrane-active region (Cramer et al., 1990). This literature does not teach how to improve the probability of this event occurring and it is not known if B. thuringiensis toxins use this same process to penetrate the membrane. Reducing the steric hindrance of the amino acid side chains in these critical regions by reducing size or altering side chain positioning with the corresponding increase in biological activity was the inventive step.

5.10.1 Analysis of the Loop Between Helices 3 and 4 (Cry3Bb.11032)

The inventors have discovered that the first three helices of domain one could be cleaved from the rest of the toxin by proteolytic digestion of the loop between helices α3 and α4 (Cry3Bb.60). Initial efforts to truncate the cry3Bb gene to produce this shortened, though more active Cry3Bb molecule, failed. For unknown reasons, B. thuringiensis failed to synthesize this 60-kDa molecule. It was then reasoned that perhaps the first three helices of domain 1 did not have to be proteolytically removed, or equivalently, the protein did not have to be synthesized in this truncated form to take advantage of the Cry3Bb.60 design. It was observed that the protein Cry3A had a small amino acid near the lα3,4 that might impart greater flexibility in the loop region thereby permitting the first three helices of domain 1 to move out of the way, exposing the membrane-active region. By designing a Cry3Bb molecule with a glycine residue near this loop, the steric hindrance of residues in the loop might be lessened. The redesigned protein, Cry3Bb.11032, has the amino acid change D165G, which replaces the larger aspartate residue (average mass of 115.09) with the smallest amino acid, glycine (average mass of 57.05). The activity of Cry3Bb.11032 is approximately 3-fold greater than that of the WT protein. In this way, the loop between helices α3 and α4 was rationally redesigned with a corresponding increase in the biological activity.

5.10.2 Cry3Bb.11051

The loop region connecting helices α4 and α5 in Cry3Bb must be flexible so that the channel-forming helices α5-α6 can penetrate into the membrane. It was noticed that Cry3A has a glycine residue in the middle of this loop that may impart greater flexibility. The corresponding change, K189G, was made in Cry3Bb and the resulting, designed protein, Cry3Bb.11051, exhibits a 3-fold increase in activity against SCRW larvae compare to WT Cry3Bb. 5.10.3 Analysis of the Loop Between β-Strand 1 and Helix 8 (Cry3Bb.11228, Cry3Bb.11229, Cry3Bb.11230, Cry3Bb.11232, Cry3Bb.11233, Cry3Bb.11236, Cry3Bb.11237, Cry3Bb.11238, AND Cry3Bb.11239)

The loop region located between β strand 1 of domain 2 and α helix 8 in domain 2 is very close to the loop between cc helices 6 and 7 in domain 1. Some of the amino acids side chains of lβ1, α8 appear as though they may sterically impede movement of lα6,7. Since lα6,7 must be flexible for the channel-forming helices α5-α6 to insert into the membrane, it was thought that re-engineering this loop may change the positioning of the side chains resulting in less steric hindrance. This was accomplished creating proteins with increased biological activities ranging from 2.2 to 5.4 times greater than WT. These designed toxin proteins and their amino acid changes are listed in Table 2 as Cry3Bb.11228, Cry3Bb.11229, Cry3Bb.11230, Cry3Bb.11232, Cry3Bb.112313, Cry3Bb.11236, Cry3Bb.11237, Cry3Bb.11238, and Cry3Bb.11239.

5.10.4 Analysis of the Loop Between Helix 7 and β-Strand 1 (Cry3Bb.11227, Cry3Bb.11234, Cry3Bb.11241, Cry3Bb.11242, and Cry3Bb.11036)

If Cry3Bb is similar to a bacterial toxin which must open up to expose a membrane active region for toxicity, it is possible that other helices in addition to the channel-forming helices must also change positions. It was reasoned that, if helices α5-α6 insert into the membrane, than helix α7 may have to change positions also. It was shown in example 4.4.3 that increasing flexibility between helix α6 and α7 can increase activity, greater flexibility in the loop following helix α7,lα7,β1 may also increase bioactivity. Alterations to the lα7,β1 region of Cry3Bb resulted in the isolation of several proteins with increased activities ranging from 1.9 to 4.3 times greater than WT. These designed proteins are listed in Table 7 as Cry3Bb.11227, Cry3Bb.11234, Cry3Bb.11241, Cry3Bb.11242, and Cry3Bb.11036.

5.11 Example 11

Design Method 5: Loop Design Around β Strands and β Sheets

Loop regions of a protein structure may be involved in numerous functions of the protein including, but not limited to, channel formation, quaternary structure formation and maintenance, and receptor binding. A binding surface is often defined by a number of loops, as is the case with immunoglobulin G (IgG) (sec Branden and Tooze, 1991, for review). What can not be determined at this point, however, is what loops will be important for receptor interactions just by looking at the structure of the protein in question. Since a receptor has not been identified for Cry3Bb, it is not even possible to compare the structure of Cry3Bb with other proteins that have the same receptor for structural similarities. To identify Cry3Bb loops that contribute to receptor interactions, random mutagenesis was performed on surface-exposed loops.

As each loop was altered, the profile of the overall bioactivities of the resultant proteins were examined and compared. The loops, especially in domain 2 which appears to be unnecessary for channel activity, fall into two categories: (1) loops that could be altered without much change in the level of bioactivity of the resultant proteins and (2) loops where alterations resulted in overall loss of resultant protein bioactivity. Using this design method, it is possible to identify several loops important for activity.

5.11.1 Analysis of Loop β2,3

Semi-random mutagenesis of the loop region between β strands 2 and 3 resulted in the production of structurally stable toxin proteins with significantly reduced activities against SCRW larvae. The lβ2,3 region is highly sensitive to amino acid changes indicating that specific amino acids or amino acid sequences ate necessary for toxin protein activity. It is conceivable, therefore, that specific changes in the lβ2,3 region will increase the binding and, therefore, the activity of the redesigned toxin protein.

5.11.2 Analysis of Loop β6,7

Semi-random mutations introduced to the loop region between β strands 6 and 7 resulted in structurally stable proteins with an overall loss of SCRW bioactivity. The lβ6,7 region is highly sensitive to amino acid changes indicating that specific amino acids or amino acid sequences are necessary for toxin protein activity. It is conceivable, therefore, that specific changes in the lβ6.7 region will increase the binding and, therefore, the activity of the redesigned toxin protein.

5.11.3 Analysis of Loop β10,11

Random mutations to the loop region between β strands 10 and 11 resulted in proteins having an overall loss of SCRW bioactivity. Loop β10,11 is structurally close to and interacts with loops β2,3 and β6,7. Specific changes to individual residues within the lβ10,11 region may also result in increased interaction with the insect membrane, increasing the bioactivity of the toxin protein.

5.11.4 Cry3Bb.11095

Loops β2,3, β6,7 and β10,11 have been identified as important for bioactivity of Cry3Bb. The 3 loops are surface-exposed and structurally close together. Amino acid Q348 in the WT structure, located in β-strand 2 just prior to lβ2,3, does not form any intramolecular contacts. However, replacing Q348 with arginine (Q348R) results in the formation of 2 new hydrogen-bonds between R348 and the backbone carbonyls of R487 and R488, both located in lβ10,11. The new hydrogen bonds may act to stabilize the structure formed by the 3 loops. The designed protein carrying this change, Cry3Bb.11095, is 4.6-fold more active than WT Cry3Bb.

5.12 Example 12

Design Method 6: Identification and Re-Design of Complex Electrostatic Surfaces

Interactions of proteins include hydrophobic interactions (e.g., Van der Waals forces), hydrophilic interactions, including those between opposing charges on amino acid side chains (salt bridges), and hydrogen bonding. Very little is known about δ-endotoxin and receptor interactions. Currently, there are no literature reports identifying the types of interactions that predominate between B. thuringiensis toxins and receptors.

Experimentally, however, it is important to increase the strength of the B. thuringiensis toxin-receptor interaction and not permit the precise determination of the chemical interaction to stand in the way of improving it. To accomplish this, the electrostatic surface of Cry3Bb was defined by solving the Poisson-Boltzman distribution around the molecule. Once this electrically defined surface was solved, it could then be inspected for regions of greatest diversity. It was reasoned that these electrostatically diverse regions would have the greatest probability of participating in the specific interactions between the B. thuringiensis toxin proteins and the receptor, rather than more general and non-specific interactions. Therefore, these regions were chosen for redesign, continuing to increase the electrostatic diversity of the regions. In addition, examination of the electrostatic interaction around the putative channel forming region of the toxin created insights for redesign. This includes identification of an electropositive residue in an otherwise negatively charged conduit (see example 4.6.1).

5.12.1 R290 (Cry3Bb.11227, Cry3Bb.11241, and Cry3Bb.11242)

Examination of the Cry3Bb dimer interface along the domain 1 axis suggested that a pore or conduit for cations might be formed between the monomers. Electrostatic examination of this axis lent additional credibility to this suggestion. In fact, the hypothetical conduit is primarily negatively charged, an observation consistent with the biophysical analysis of cation-selective, δ-endotoxin channels. If a cation channel were formed along the axis of the dimer, then the cation could move between the monomers relatively easily with only one significant hurdle. A positively charged arginine residue (R290) lies in the otherwise negatively charged conduit. This residue could impede the cation movement through the channel. Based on this analysis, R290 was changed to uncharged residues. The bioactivity of redesigned proteins Cry3Bb.11227 (R290N), Cry3Bb.11241 (R290L) and Cry3Bb.11242 (R290V) was improved approximately 2-fold, 2.6-fold and 2.5-fold, respectively.

5.12.2 Cry3Bb.60

Trypsin digestion of solubilized Cry3Bb yields a stable, truncated protein with a molecular weight of 60 kDa (Cry3Bb.60). Trypsin digestion occurs on the carboxyl side of residue R159, effectively removing helices 1 through 3 from the native Cry3Bb structure. The cleavage of the first 3 helices exposes an electrostatic surface different than those found in the native structure. The new surface has a combination of hydrophobic, polar and charged characteristics that may play a role in membrane interactions. The bioactivity of Cry3Bb.60 is 3.6-fold greater than that of WT Cry3Bb.

5.13 Example 13

Design Method 7: Identification and Removal of Metal Binding Sites

The literature teaches that the in vitro behavior of B. thuringiensis toxins can be increased by chelating divalent cations from the experimental system (Crawford and Harvey 1988). It was not known, however, how these divalent cations inhibited the in vitro activity. Crawford and Harvey (1988) demonstrated that the short circuit current across the midgut was more severely inhibited by B. thuringiensis in the presence of EDTA, a chelator of divalent ions, than in the absence of this agent, thus suggesting that this step in the mode of action of B. thuringiensis could be potentiated by removing divalent ions. Similar observations were made using black-lipid membranes and measuring an increase in the current created by the δ-endotoxins in the presence of EDTA to chelate divalent ions. There were at least three possible explanations for these observations. The first explanation could be that the divalent ions are too large to move through a ion channel more suitable for monovalent ions, thereby blocking the channel. Second, the divalent ions may cover the protein in the very general way, thereby buffering the charge interactions required for toxin membrane interaction and limiting ion channel activity. The third possibility is that a specific metal binding site exists on the protein and, when occupied by divalent ions, the performance of the ion channel is impaired. Although the literature could not differentiate the value of one possibility over another, the third possibility led to an analysis of the Cry3Bb structure searching for a specific metal binding site that might alter the probability that a toxin could form an ion channel.

5.13.1 H231 (Cry3Bb.11222, Cry3Bb.11224, Cry3Bb.11225, and Cry3Bb.11226)

A putative metal binding site is formed in the Cry3Bb dimer structure by the H231 residues of each monomer. The H231 residues, located in helix α6, lie adjacent to each other and close to the axis of symmetry of the dimer. Removal of this site by replacement of histidine with other amino acids was evaluated by the absence of EDTA-dependent ion channel activity. The bioactivities of the designed toxin proteins, Cry3Bb.11222, Cry3Bb.11224, Cry3Bb.11225 and Cry3Bb.11226, are increased 4-, 5-, 3.6- and 3-fold, respectively, over that of WT Cry3Bb. Their respective amino acid changes are listed in Table 2.

5.14 Example 14

Design Method 8: Alteration of Quaternary Structure

Cry3Bb can exist in solution as a dimer similar to a related protein, Cry3A (Walters et al., 1992). However, the importance of the dimer to biological activity is not known because the toxin as a monomer or as a higher order structure has not been seriously evaluated. It is assumed that specific amino acid residues contribute to the formation and stability of the quaternary structure. Once a contributing residue is identified, alterations can be made to diminish or enhance the effect of that residue thereby affecting the interaction between monomers. Channel activity is a useful way, but by no means the only way, to assess quaternary structure of Cry3Bb and its derivatives. It has been observed that Cry3Bb creates gated conductances in membranes that grow in size with time, ultimately resulting in large pores in the membrane (the channel activity of WT Cry3Bb is described in Section 12.1). It also has been observed that Cry3A forms a more stable dimer than Cry3Bb and coincidentally forms higher level conductances faster (FIG. 10). This observation led the inventors to propose that oligomerization and ion channel formation (conductance size and speed of channel formation) were related. Based on this observation Cry3Bb was reengineered to make larger and more stable oligomers at a faster rate. It is assumed in this analysis that the rate of ion channel formation and growth mirrors this process. It is also possible that changes in quaternary structure may not affect channel activity alone or at all. Alterations to quaternary structure may also affect receptor interactions, protein processing in the insect gut environment, as well as other aspects of bioactivity unknown.

5.14.1 Cry3Bb.11048

Comparative structural analysis of Cry3A and Cry3Bb led to the identification of structural differences between the two toxins in the ion channel-forming domain; specifically, an insertion of one amino acid between helix 2a and helix 2b in Cry3Bb. Removal of this additional amino acid in Cry 3B2, A104, and a D103E substitution, as in Cry3A, resulted in loss of channel gating and the formation of symmetrical pores. Once the pores are formed they remain open and allow a steady conductance ranging from 25-130 pS. This designed protein, Cry3Bb.11048, is 4.3 times more active than WT Cry3Bb against SCRW larvae.

5.14.2 Oligomerization of Cry3Bb.60

Individual molecules of Cry3Bb or Cry3Bb.60 can form a complex with another like molecule. Oligomerization of Cry3Bb is demonstrated by SDS-PAGE, where samples are not heated in sample buffer prior to loading on the gel. The lack of heat treatment allows some nondenatured toxin to remain. Oligomerization is visualized following Coomassie staining by the appearance of a band at 2 times the molecular weight of the monomer. The intensity of the higher molecular weight band reflects the degree of oligomerization. The ability of Cry3Bb to form an oligomer is not reproducibly apparent. The complex cannot be repeatedly observed to form. Cry3Bb.60, however, forms a significantly greater amount of a higher molecular weight complex (120 kDa). These data suggest that Cry3Bb.60 more readily forms the higher order complex than Cry3Bb alone. Cry3Bb.60 also forms ion channels with greater frequency than WT Cry3Bb (see Section 5.12.9).

5.14.3 Cry3Bb.11035

Changes were made in Cry3Bb to reflect the amino acid sequence in Cry3A at the end of lα3,4 and in the beginning of helix 4. These changes resulted in the designed protein, Cry3Bb.11035, that, unlike wild type Cry3Bb, forms Spontaneous channels with large conductances. Cry3Bb.11035 is also approximately three limes more active against SCRW larvae than WT Cry3Bb. Cry3Bb.11035 and its amino acid changes are listed in Table 10.

5.14.4 Cry3Bb.11032

Cry3Bb.11032 was altered at residue 165 in helix α4, changing an asparate to glycine, as found in Cry3A. Cry3Bb.11032 is three-fold more active than WT Cry3Bb. The channel activity of Cry3Bb.11032 is much like Cry3Bb except when the designed protein is artificially incorporated into the membrane. A 16-fold increase in the initial channel conductances is observed compared to WT Cry3Bb (see Section 5.12.2). This increase in initial conductance presumably is due to enhanced quaternary structure, stability or higher-order structure.

5.14.5 EG11224

In the WT Cry3Bb dimer structure, histidine, at position 231 in domain 1, makes hydrogen bond contacts with D288 (domain 1), Y230 (domain 1), and, through a network of water molecules, also makes contacts to D610 (domain 3), all of the opposite monomer. D610 and K235 (domain 1) also make contact. Replacing the histidine with an arginine, H231R, results, in one orientation, in the formation of a salt bridge to D610 of the neighboring monomer. In a second orientation, the contacts with D288 of the neighboring monomer, as appear in the WT structure, are retained. In either orientation, R231 does not hydrogen bond to Y230 of the opposite monomer but does make contact with K235 which retains is contacts to K610 (V. Cody, research communication). The shifting hydrogen bonds have changed the interactions between the different domains of the protein in the quaternary structure. Overall, fewer hydrogen bonds exist between domains 1 of the neighboring monomers and a much stronger bond has been formed between domains 1 and 3. Channel activity was found to be altered. Cry3Bb.11224 produces small, quickly gating channels like Cry3Bb. However, unlike WT Cry3Bb, Cry3Bb.11224 does not exhibit β-mercaptoethanol-dependent activation. Replacing H231 with arginine resulted in a designed Cry3Bb protein, Cry3Bb. 11224, exhibiting a 5-fold increase in bioactivity.

5.14.6 Cry3Bb.11226

Cry3Bb.11226 is similar to Cry3Bb.11224, discussed in Section 4.8.5, in that the histidine at position 231 has been replacer. The amino acid change, H231T, results in the loss of β-mercaptoethanol dependent activation seen with WT Cry3Bb (see Section 5.12.1). The replacement of H231, a putative metal binding site, changes the interaction of regions in the quaternary structure resulting in a different type of channel activity. Cry3Bb.11226 is three-fold more active than WT Cry3Bb.

5.14.7 Cry3Bb.11221

Cry3Bb.11221 has been re-designed in the lα3,4 region of Cry3Bb. The channels formed by Cry3Bb.1 1221 are much more well resolved than the conductances formed by WT Cry3Bb (see Section 5.12.6). Cry3Bb.11221 exhibits a 6.4-fold increase in bioactivity over that of WT Cry3Bb. The amino acid changes found in Cry3Bb.11221 are listed in Table 2.

5.14.8 Cry3Bb.11242

The designed protein, Cry3Bb.11242, carrying the alteration R290V, forms small conductances immediately which grow rapidly and steadily to large conductances in about 3 min (see Section 5.12.7). This is contrast to WT Cry3Bb channels which take 30-45 min to appear and grow slowly over hours to large conductances. Cry3Bb.11242 also exhibits a 2.5-fold increase in bioactivity compared to WT Cry3Bb.

5.14.9 Cry3Bb. 11230

Cry3Bb.11230, unlike WT Cry3Bb, forms well resolved channels with long open states. These channels reach a maximum conductance of 3000 pS but do not continue to grow with time. Cry3Bb.11230 has been re-designed in the lβ1,α8 region of Cry3Bb and exhibits almost a 5-fold increase in activity against SCRW larvae (Table 9) and a 5.4-fold increase against WCRW larvae (Table 10) compared to WT Cry3Bb. The amino acid changes found in Cry3Bb.11230 are listed in Table 2.

5.15 Example 15

Design Method 9: Design of Structural Residues

The specific three-dimensional structure of a protein is held in place by amino acids that may be buried or otherwise removed from the surface of the protein. These structural determinants can be identified by inspection of forces responsible for the surface structure positioning. The impact of these structural residues can then be enhanced to restrict molecular motion or diminished to enhance molecular flexibility.

5.15.1 Cry3Bb.11095

Loops β2,3, β6,7 and β10,11, located in domain 2 of Cry3Bb, have been identified as important for bioactivity. The three loops are surface-exposed and structurally close together. Amino acid Q348 in WT structure, located in β-strand 2 just prior to lβ2,3, does not form any intramolecular contacts. However, replacing Q348 with arginine (Q348R) results in the formation of 2 new hydrogen-bonds between R348 and the backbone carbonyls of R487 and R488, both located in lβ10,11. The new hydrogen bonds may act to stabilize the structure formed by the three loops. Certainly, the structure around R348 is more tightly packed as determined by X-ray crystallography. The designed protein carrying this change, Cry3Bb.11095, is 4.6-fold more active than WT Cry3Bb.

5.16 Example 16

Design Method 10: Combinatorial Analysis and Mutagenesis

Individual sites in the engineered Cry3Bb molecule can be used together to create a Cry3Bb molecule with activity even greater than the activity of any one site. This method has not been precisely applied to any δ-endotoxin. It is also not obvious that improvements in two sites can be pulled together to improve the biological activity of the protein. In fact, data demonstrates that improvements to 2 sites, when pulled together into a single construct, do not necessarily further improve the biological activity of Cry3Bb. In some cases, the combination resulted in decreased protein stability and/or activity. Examples of proteins with site combinations that resulted in improved activity compared to WT Cry3Bb but decreased activity compared to 1 or more of the "parental" proteins are Cry3Bb.11235, 11046, 11057 and 11058. Cry3Bb.11082, which contains designed regions from 4 parental proteins, retains the level of activity from the most active parental strain (Cry3Bb. 11230) but does not show an increase in activity. These proteins are listed in Table 7. The following are examples of instances where combined mutations have significantly improved biological activity.

5.16.1 Cry3Bb.11231

Designed protein Cry3Bb.11231 contains the alterations found in Cry3Bb.11224 (H123R) and Cry3Bb.11228 (changes in lβ1,α8). The combination of amino acid changes found in Cry3Bb.11231 results in an increase in bioactivity against SCRW larvae of approximately 8-fold over that of WT Cry3Bb (Table 2). This increase is greater than exhibited by either Cry3Bb.11224 (5.0×) or Cry3Bb.11228 (4.1×) alone. Cry3Bb.11231 was also exhibits an 12.9-fold increase in activity compared to WT Cry3Bb against WCRW larvae (Table 10).

5.16.2 Cry3Bb.11081

Designed Cry3Bb protein Cry3Bb.11081 was constructed by combining the changes found in Cry3Bb.11032 and Cry3Bb.11229 (with the exception of Y318C). Cry3Bb.11081 a 6.1 -fold increase in activity over WT Cry3Bb; a greater increase in activity than either of the individual parental proteins, Cry3Bb.11032 (3.1-fold) and Cry3Bb.11229 (2.5-fold).

5.16.3 Cry3Bb.11083

Designed Cry3Bb protein Cry3Bb.11083 was constructed by combining the changes found in Cry3Bb.11036 and Cry3Bb.11095. Cry3Bb.11083 exhibits a 7.4-fold increase in activity against SCRW larvae compared to WT Cry3Bb; a greater increase than either Cry3Bb.11036 (4.3×) or Cry3Bb.11095 (4.6×). Cry3Bb.11083 also exhibits a 5.4-fold increase in activity against WCRW larvae compared to WT Cry3Bb (Table 10).

5.16.4 Cry3Bb.11084

Designed Cry3Bb protein Cry3Bb.11084 was constructed by combining the changes found in Cry3Bb.11032 and the S311L change found in Cry3Bb.11228.

Cry3Bb.11084 exhibits a 7.2-fold increase in activity over that of WT Cry3Bb; a greater than either Cry3Bb.11032 (3×) or Cry3Bb.11228 (4×).

5.16.5 Cry3Bb.11098

Designed Cry3Bb protein Cry3Bb.11098 was constructed to contain the following amino acid changes: D165G, H231R, S311L, N313T, and E317K. The nucleic acid sequence is given in SEQ ID NO:107, and the encoded amino acid sequence is given in SEQ ID NO:108.

5.17 Example 17

Design Strategy 11: Alteration of Binding to Glycoproteins and to WCRW Brush Border Membranes

While the identity of receptor(s) for Cry3Bb is unknown, it is nonetheless important to increase the interaction of the toxin with its receptor. One way to improve the toxin-receptor interaction with knowing the identity of the receptor is to reduce or eliminate non-productive binding to other biomolecules. The inventors have observed that Cry3Bb binds non-specifically to bovine serum albumin (BSA) that has been glycosylated with a variety of sugar groups, but not to non-glycosylated BSA. Cry3A, which is not active on Diabrotica species, shows similar but even greater binding to glycosylated-BSA. Similarly, Cry3A shows greater binding to immobolized WCRW brush border membrane (BBM) than does WT Cry3Bb, suggesting that much of the observed binding is non-productive. It was reasoned that the non-specific binding to WCRW BBM occurs via glycosylated proteins, and that binding to both glycosylated-BSA and WCRW BBM is non-productive in reaction pathway to toxicity. Therefore reduction or elimination of that binding would lead to enhanced binding to the productive receptor and to enhanced toxicity. Potential binding sites for sugar groups were targeted for redesign to reduce the non-specific binding of Cry3Bb to glycoproteins and to immobilized WCRW BBM.

5.17.1 Cry3Bb.60

Cry3Bb-60, in which Cry3Bb has been cleaved at R159 in lα3,4, shows decreased binding to glycosylated-BSA and decreased binding to immobilized WCRW BBM. Cry3Bb-60 shows a 3.6-fold increase in bioactivity relative to WT Cry3Bb.

5.17.2 Alterations to lα3,4 (Cry3Bb.11221)

Cry3Bb.11221 has been redesigned in the lα3,4 region of domain 1, which is the region in which Cry3Bb is cleaved to produce Cry3Bb-60. Cry3Bb.11221 also shows decreased binding to both glycosylated-BSA and immobilized WCRW BBM, and exhibits a 6.4-fold increase in bioactivity over that of WT Cry3Bb. Together with data for Cry3Bb.60 (section 5.17.1) these data suggest that this loop region contributes substantially to non-productive binding of the toxin.

5.17.3 Alteration to lβ1,α8 (Cry3Bb.11228,11230,11237 and 11231)

The lβ1,α8 region of Cry3Bb has been re-engineered to increase hydration (section 4.2.4) and enhance flexibility (section 4.4.3). Several proteins altered in this region, Cry3Bb.11228,11230, and 11237 demonstrate substantially lower levels of binding both glycosylated-BSA and immobilized WCRW BBM, and also show between 4.1- and 4.5-fold increases in bioactivity relative to WTF Cry3Bb.

5.17.4 Binding Activity

The tendencies of Cry3Bb and some of its derivatives to bind to glycosylated-BSA and to WCRW BBM were determined using a BIAcore™ surface plasmon resonance biosensor. For glycosylated-BSA binding, the glycosylated protein was immobilized using standard NHS chemistry to a CM5 chip (BIAcore), and the solubilized toxin was injected over the glycosylated-BSA surface. To measure binding to WCRW BBM, brush border membrane vesicles (BBMV) purified from WCRW midguts (English et al., 1991) were immobilized on an HPA chip (BIAcore) then washed with either 10 mM KOH or with 40mM β-octylglucoside. The solubilized toxin was then injected over the resulting hybrid bilayer surface to detect binding. Protein concentration were determined by Protein Dye Reagent assay (BioRad) or BCA Protein Assay (Pierce).

Other methods may also be used to determine the same binding information. These include, but are not limited to, ligand blot experiments using labeled toxin, labeled glycosylated protein, or anti-toxin antibodies, affinity chrormatography, and in vitro binding of toxin to intact BBMV.

5.18 Example 18

Construction of Plasmids with WT Cry3Bb Sequences

Standard recombinant DNA procedures were performed essentially as described by Sambrook et al., (1989).

5.18.1 pEG1701

pEG1701 (FIG. 11), contained in EG11204 and EG11037, was constructed by inserting the SphI-PstI fragment containing the cry3Bb gene and the cry1F terminator from pEG911 (Baum, 1994) into the SphI-PstI site of pEG854.9 (Baum et al., 1996), a high copy number B. thuringiensis--E. coli shuttle vector.

5.18.2 PEG1028

pEG1028 contains the HindIII fragment of cry3Bb from pEG1701 cloned into the multiple cloning site of pTZ18U at HindIII.

5.19 Example 19

Construction of Plasmids with Altered Cry3Bb Genes

Plasmid DNA from E. coli was prepared by the alkaline lysis method (Maniatis et al., 1982) or by commercial plasmid preparation kits (examples: PERFECTprep™ kit, 5 Prime--3 Prime, Inc., Boulder CO; QIAGEN plasmid prep kit, QIAGEN Inc.). B thuringiensis plasmids were prepared from cultures grown in brain heart infusion plus 0.5% glycerol (BHIG) to mid logarithmic phase by the alkaline lysis method. When necessary for purification, DNA fragments were excised from an agarose gel following electrophoresis and recovered by glass milk using a Geneclean II® kit (BIO 101 Inc., La Jolla, Calif.). Alteration of the cry3Bb gene was accomplished using several techniques including site-directed mutagenesis, triplex PCR™, quasi-random PCR™ mutagenesis, DNA shuffling and standard recombinant techniques. These techniques are described in Sections 6.1, 6.2, 6.3, 6.4 and 6.5, respectively. The DNA sequences of primers used are listed in Section 7.

5.20 Example 20

Site-Directed Mutagenesis

Site-directed mutagenesis was conducted by the protocols established by Kunkle (1985) and Kunkle et al. (1987) using the Muta-Gene™ M13 in vitro mutagenesis kit (Bio-Rad, Richmond, Calif.). Combinations of alterations to cry3Bb were accomplished by using the Muta-Gene Tm kit and multiple mutagenic, oligonucleotide primers.

5.20.1 pEG1041

pEG 1041, contained in EG11022, was constructed using the Muta-Gene™ kit, primer C, and single-stranded pEG1028 as the DNA template. The resulting altered cry3Bb DNA sequence was excised as a PflMI DNA fragment and used to replace the corresponding DNA fragment in pEG1701.

5.20.2 pEG1046

pEG1046, contained in EG11035, was constructed using the Muta-Gene™ kit, primer D, and single-stranded pEG1028 as the DNA template. The resulting altered cry3Bb DNA sequence was excised as a PflMI DNA fragment and used to replace the corresponding DNA fragment in pEG1701.

5.20.3 pEG1047

pEG1047, contained in EG11036, was constructed using the Muta-Gene™ kit, primer E, and single-stranded pEG1028 as the DNA template. The resulting altered cry3Bb DNA sequence was excised as a PflMI DNA fragment and used to replace the corresponding DNA fragment in pEG1701.

5.20.4 pEG1052

pEG1052, contained in EG11046, was constructed using the Muta-Gene™ kit, primers D and E, and single-stranded pEG1028 as the DNA template. The resulting altered cry3Bb DNA sequence was excised as a PflMI DNA fragment and used to replace the corresponding DNA fragment in pEG 1701.

5.20.5 pEG1054

pEG1054, contained in EG11048, was constructed using the Muta-Gene™ kit, primer F, and single-stranded pEG1028 as the DNA template. The resulting altered cry3Bb DNA sequence was excised as a PflMI DNA fragment and used to replace the corresponding DNA fragment in pEG1701.

5.20.6 pEG1057

pEG1057, contained in EG11051, was constructed using the Muta-Gene™ kit, primer G, and single-stranded pEG1028 as the DNA template. The resulting altered cry3Bb DNA sequence was excised as a PflMI DNA fragment and used to replace the corresponding DNA fragment in pEG1701.

5.21 Example 21

Triplex PCR™

Triplex PCR™ is described by Michael (1994). This method makes use of a thermostable ligase to incorporate a phosphorylated mutagenic primer into an amplified DNA fragment during PCR™. PCR™ was preformed on a Perkin Elmer Cetus DNA Thermal Cycler (Perkin-Elmer, Norwalk, Conn.) using a AmpliTaq™ DNA polymerase kit (Perkin-Elmer) and SphI-linearized pEG1701 as the template DNA. PCR™ products were cleaned using commercial kits such as Wizard™ PCR™ Preps (Promega, Madison, Wis.) and QIAquick PCR™ Purification kit (QIAGEN Inc., Chatsworth, Calif.).

5.21.1 pEG1708 and pEG1709

pEG1708 and pEG1709, contained in EG11222 and EG11223, respectively, were constructed by replacing the PflMI--PflMI fragment of cry3Bb in pEG1701 with PflMI-digested and gel purified PCR™ fragment altered at cry3Bb nucleotide positions 688-690, encoding amino acid Y230. Random mutations were introduced into the Y230 codon by triplex PCR™. Mutagenic primer MVT095 was phosphorylated and used together with outside primer pair FW001 and FW006. Primer MVT095 also contains a silent mutation at position 687, changing T to C, which, upon incorporation, introduces an additional EcoRI site into pEG1701.

5.21.2 pEG1710, pEG1711 and pEG1712

Plasmids pEG1710, pEG1711 and pEG1712, contained in EG11224, EG11225 and EG11226, respectively, were created by replacing the PflMI--PflMI fragment of the cry3Bb gene in pEG1701 with PflMI-digested and gel purified PCR™ fragment altered at cry3Bb nucleotide positions 690-692, encoding H231. Random mutations were introduced into the H231 codon by triplex PCR™. Mutagenic primer MVT097 was phosphorylated and used together with outside primer pair FW001 and FW006. Primer MVT097 also contains a T to C sequence change at position 687 which, upon incorporation, results in an additional EcoRI site by silent mutation.

5.21.3 pEG1713 and pEG1727

pEG1713 and pEG1727, contained in EG11227 and EG11242, respectively, were constructed by replacing the PflMI--PflMI fragment of the cry3Bb gene in pEG1701 with PflMI-digested and gel purified PCR™ fragment altered at cry3Bb nucleotide positions 868-870, encoding amino acid R290. Triplex PCR™ was used to introduce random changes into the R290 codon. The mutagenic primer, MVT091, was designed so that the nucleotide substitutions would result in approximately 36% of the sequences encoding amino acids D or E. MVT091 was phosphorylated and used together with outside primer pair FW001 and FW006.

5.22 Example 22

Quasi-Random PCR™ Mutagenesis

Quasi-random mutagenesis combines the mutagenic PCR™ techniques described by Vallette et al. (1989), Tomic et al. (1990) and LaBean and Kauffman (1993). Mutagenic primers, sometimes over 70 nucleotides in length, were designed to introduce changes over nucleotide positions encoding for an entire structural region, such as a loop. Degenerate codons typically consisted of a ratio of 82% WT nucleotide plus 6% each of the other 3 nucleotides per position to semi-randomly introduce changes over the target region (LaBean and Kauffman, 1993). When possible, natural restriction sites were utilized; class 2s enzymes were used when natural sites were not convenient (Stemmer and Morris, 1992, list additional restriction enzymes useful to this technique). PCR™ was performed on a Perkin Elmer Cetus DNA Thermal Cycler (Perkin-Elmer, Norwalk, Conn.) using a AmpliTaq™ DNA polymerase kit (Perkin-Elmer) and SphI-linearized pEG1701 as the template DNA. Quasi-random PCR™ amplification was performed using the following conditions: denaturation at 94° C. for 1.5 min.; annealing at 50° C. for 2 min. and extension at 72° C. for 3 min., for 30cycles. The final 14 extension cycles were extended an additional 25 s per cycle. Primers concentration was 20 pM per reaction or 40 μM for long, mutagenic primers. PCR™ products were cleaned using commercial kits such as Wizard™ PCR™ Preps (Promega, Madison, Wis.) and QIAquickPCR™ Purification kit (QIAGEN Inc., Chatsworth, Calif). In some instances PCR™ products were treated with Klenow Fragment (Promega) following the manufacturer's instructions to fill in any single base overhangs prior to restriction digestion.

5.22.1 pEG1707

EG1707, contained in EG11221, was constructed by replacing the PflMI--PflMI fragment of the cry3Bb gene in pEG1701 with PflMI-digested and gel purified PCR™ fragment altered at cry3Bb nucleotide positions 460-480, encoding lα3,4 amino acids 154-160. Primer MVT075, which includes a recognition site for the class 2s restriction enzyme BsaI, and primer FW006 were used to introduce changes into this region by quasi-random mutagenesis. Primers MVT076, also containing a BsaI site, and primer FW001 were used to PCR™ amplify a "linker" fragment. Following PCR™ amplification, both products were cleaned, end-filled, digested with BsaI and ligated to each other. Ligated fragment was gel purified and used as template for PCR™ amplification using primer pair FW001 and FW006. PCR™ product was cleaned, digested with PflMI, gel purified and ligated into PflMI-digested and purified pEG1701 vector DNA.

5.22.2 pEG1720 and pEG1726

pEG1720 and pEG1726, contained in EG11234 and EG11241, respectively, were constructed by replacing the PflMI--PflMI fragment of the cry3Bb gene in pEG1701 with PflMI-digested and gel purified PCR™ fragment altered at cry3Bb nucleotide positions 859-885, encoding lα7,β1 amino acids 287-295. Quasi-random PCR™ mutagenesis was used to introduce changes into this region. Mutagenic primer MVT111, designed with a BsaI site, and primer FW006 were used to introduce the changes. Primer pair MVT094, also containing a BsaI site, and FW001 were used to amplify the linker fragment. The PCR™ products were digested with BsaI, gel purified then ligated to each other. Ligated product was PCR™ amplified using primer pair FW001 and FW006, digested with PflMI.

5.22.3 pEG1714, pEG1715, pEG1716, pEG1718, pEG1719, pEG1722, pEG1723, pEG1724 and pEG1725

pEG1714, pEG1715, pEG1716, pEG1718, pEG1719, pEG1722, pEG1723, pEG1724 and pEG1725, contained in EG11228, EG11229, EG11230, EG11232, EG11233, EG11236, EG11237, EG11238 and EG11239, respectively, were constructed by replacing the PflMI--PflMI fragment of the cry3Bb gene in pEG1701 with PflMI-digested and gel purified PCR™ fragment altered at cry3Bb nucleotide positions 931-954, encoding lβ1,α8 amino acids 311-318. Quasi-random PCR™ mutagenesis was used to introduce changes into this region using mutagenic primer MVT103 and primer FW006. Primers FW001 and FW006 were used to amplify a linker fragment. The PCR™ products were end-filled using Klenow and digested with BamHI. The larger fragment from the FW001-FW006 digest was gel purified then ligated to the digested MVT103-FW006 fragment. Ligated product was gel purified and amplified by PCR™ using primer pair FW001 and FW006. The amplified product was digested with PflMI and gel purified prior to ligation into PflMI-digested and purified pEG1701 vector DNA.

5.22.4 pEG170.lβ2.3

Plasmids carrying alterations of cry3Bb WT sequence at nucleotides 1051-1065, encoding structural region lβ2,3 of Cry3Bb, were constructed by replacing the MluI-SpeI fragment of pEG1701 with isolated MluI- and SpeI-digested PCR™ product. The PCR™ product was generated by quasi-random PCR™ mutagenesis were mutagenic primer MVT081 was paired with FW006. These plasmids as a group are designated pEG1701.lβ2,3.

5.22.5 pEG1701.lβ6,7

Plasmids containing mutations of the cry3Bb WT sequence at nucleotides 1234-1248, encoding structural region lβ6,7 of Cry3Bb, were constructed by replacing the MluI-SpeI fragment of pEG1701 with isolated MluI- and SpeI-digested PCR™ product. The PCR™ product was generated by quasi-random PCR™ mutagenesis where mutagenic primer MVT085 was paired with primer WD115. Primer pair MVT089 and WD112 were used to amplify a linker fragment. Both PCR™ products were digested with TaqI and ligated to each other. The ligation product was gel purified and PCR™ amplified using primer pair MVT089 and FW006. The amplified product was digested with MluI and SpeI and ligated into MluI and SpeI digested and purified pEG1701 vector DNA. These plasmids as a group are designated pEG1701.lβ6,7.

5.22.6 pEG1701.lβ10,11

Plasmids containing mutated cry3Bb sequences at nucleotides 1450-1467, encoding structural region lβ10,11 of Cry3Bb, were constructed by replacing the SpeI-PstI fragment of pEG1701 with isolated SpeI- and PstI-digested PCR™ product. The PCR™ product was generated by quasi-random PCR™ mutagenesis where mutagenic primer MVT105 was paired with primer MVT070. Primer pair MVT092 and MVT083 were used to generate a linker fragment. (MVT083 is a mutagenic oligo designed for another region. The sequence changes introduced by MVT083 are removed following restriction digestion and do not impact the alteration of cry3Bb in the lβ10,11 region.) Both PCR™ products were digested with BsaI, ligated together, and the ligation product PCR™ amplified with primer pair MVT083 and MVT070. The resulting PCR™ product was digested with speI and PstI, and gel purified. These plasmids as a group are designated pEG1701.lβ10,11.

5.23 Example 23

DNA Shuffling

DNA-shuffling, as described by Stemmer (1994), was used to combine individual alterations in the cry3Bb gene.

5.23.1 pEG1084, pEG1085, pEG1086 and pEG1087

pEG1084, pEG1085, pEG1086, and pEG1087, contained in EG11081, EG11082, EG11083, and EG11084, respectively, were recovered from DNA-shuffling. Briefly, PflMI DNA fragments were generated using primer set A and B and each of the plasmids pEG1707, pEG1714, pEG1715, pEG1716, pEG1041, pEG1046, pEG1047, and pEG1054 as DNA templates. The resulting DNA fragments were pooled in equal-molar amounts and digested with DNaseI and 50-100 bp DNA fragments were recovered from an agarose gel by three successive freeze-thaw cycles: three min in a dry-ice ethanol bath followed by complete thawing at 50° C. The recovered DNA fragments were assembled by primerless-PCR™ and PCR™-amplified using the primer set A and B as described by Stemmer (1994). The final PCR™-amplified DNA fragments were cut with PflMI and used to replace the corresponding cry3Bb PflMI DNA fragment in pEG1701.

5.24 Example 24

Recombinant DNA Techniques

Standard recombinant DNA procedures were performed essentially as described by Sambrook et al. (1989).

5.24.1 pEG1717

pEG1717, contained in EG11231, was constructed by replacing the small BglII fragment of pEG1710 with the small BglII fragment from pEG1714.

5.24.2 pEG1721

pEG1721, contained in EG11235, was constructed by replacing the small BglII fragment from pEG1710 with the small BglII fragment from pEG1087.

5.24.3 pEG1063

pEG1062, contained in EG11057, was constructed by replacing the NcoI DNA fragment containing ori 43 from pEG1054 with the isolated NcoI DNA fragment containing ori 43 and the alterations in cry3Bb from pEG 1046.

5.24.4 pEG1063

pEG1063, contained in EG11058, was constructed by replacing the NcoI DNA fragment containing ori 43 from pEG1054 with the isolated Ncol DNA fragment containing ori 43 and the alterations in cry3Bb from pEG 1707.

5.24.5 pEG1095

pEG1095, contained in EG11095, was constructed by replacing the MluI-SpeI DNA fragment in pEG1701 with the corresponding MluI-SpeI DNA fragment from pEG1086.

5.25 Example 25

Primers Utilized in Constructing Cry3Bb* Variants

Shown below are the primers used for site-directed mutagenesis, triplex PCR™ and quasi-random PCR™ to prepare the cry3Bb* variants as described above. Primers were obtained from Ransom Hill Bioscience, Inc. (Ramona, Calif.) and Integrated DNA Technologies, Inc. (Coralville, Iowa). The specific composition of the primers containing particular degeneracies at one or more residues is given in Section 5.30, Example 30.

5.25.1 Primer FW001 (SEQ ID NO:71):

5'-AGACAACTCTACAGTAAAAGATG-3'

5.25.2 Primer FW006 (SEQ ID NO:72):

5'-GGTAATTGGTCAATAGAATC-3'

5.25.3 Primer MVT095 (SEQ ID NO:73):

5'-CAGAAGATGTTGCTGAATTCNNNCATAGACAATTAAAAC-3'

5.25.4 Primer MVT097 (SEQ ID NO:74):

5'-GATGTTGCTGAATTCTATNNNAGACAATTAAAAC-3'

5.25.5 Primer MVT091 (SEQ ID NO:75):

5'-CCCATTTTATGATATTBDNTTATACTCAAAAGG-3'

5.25.6 Primer MVT075 (SEQ ID NO:76):

5'-AGCTATGCTGGTCTCGGAAGAAAEFNFFNFJNJFJFJNFINJFJAAAAGAAGCCAAGATCGAAT-3'

5.25.7 Primer MVT076 (SEQ ID NO:77):

5'-GGTCACCTAGGTCTCTCTTCCAGGAATTTAACGCATTAAC-3'

5.25.8 Primer MVT111 (SEQ ID NO:78):

5'-AGCTATGCTGGTCCCATTTJEHIEJEJJEIIKRRJEHEIJEENIIIGTTAAAACAGAACTAAC-3'

5.25.9 Primer MVT094 (SEQ ID NO:79):

5'-ATCCAGTGGGGTCTCAAATGGGAAAAGTACAATTAG-3'

5.25.10 Primer MVT103 (SEQ ID NO:80):

5'-CATTTTTACGGATCCAATTTTTJFFFJNEEJEFNFJNFEILEIJEOGGACCAACTTTTTTGAG-3'

5.25.11 Primer MVT081 (SEQ ID NO:81):

5'-GAAITTTCATACGCGTCTTCAACCGGJEHJJJINMEEIEJTCTTTCAATTATTGGTCTGG-3'

5.25.12 Primer MVT085 (SEQ ID NO:82):

5'-AAAAGTTTATCGAACTATAGCTAATACAGACGTAGCGGCTJQQFFNEEJIIJEEIGTATATTTAGGTGTTACG-3'

5.25.13 Primer A (SEQ ID NO:83) 3b2pflm1:

5'-GGAGTTCCATTTGCTGGGGC-3'

5.25.14 Primer B (SEQ ID NO:84) 3b2pflm2:

5'-ATCTCCATAAAATGGGG-3'

5.25.15 Primer C (SEQ ID NO:85) 3b2165DG:

5'-GCGAAGTAAAAGAAGCCAAGGTCGAATAAGGG-3'

5.25.16 Primer D (SEQ ID NO:86) 3b2160SKRD:

5'-CCTTTAAGTTTGCGAAATCCACACAGCCAAGGTCGAATAAGGG-3'

5.25.17 Primer E (SEQ ID NO:87) 3b2290VP:

5'-CCCATTTTATGATGTTCGGTTATACCCAAAAGGGG-3'

5.25.18 Primer F (SEQ ID NO:88) 3b2EdA104:

5'-GGCCAAGTGAAGACCCATGGAAGGC-3'

5.25.19 Primer G (SEQ ID NO:89) 3b2KG189:

5'-GCAGTTTCCGGATTCGAAGTGC-3'

5.25.20 Primer WD112 (SEQ ID NO:90):

5'-CCGCTACGTCTGTATTA-3'

5.25.21 Primer WD115 (SEQ ID NO:91): 5'-ATAATGGAAGCACCTGA-3' 5.25.22 Primer MVT105 (SEQ ID NO:92):

5'-AGCTATGCTGGTCTCTTCTTAEJIFEIIEFFIJFIJIINACAATTCCATTTTTTACTTGG-3'

5.25.23 Primer MVT092 (SEQ ID NO:93):

5'-ATCCAGTTFGGGTCTCTAAGAAACAAACCGCGTAATTAAGC-3'

5.25.24 Primer MVT070 (SEQ ID NO:94):

5'-CCTCAAGGGTTATAACATCC-3'

5.25.25 Primer MVT083 (SEQ ID NO:95):

5'-GTACAAAAGCTAAGCTTTIEJIINPEEMEEIJNJESCGAACTATAGCTAATACAG-3'

5.26 Example 26

Sequence Analysis of Altered Cry3Bb Genes

E. coli DH5α™ (GIBCO BRL, Gaithersburg, Md.), JM110 and Sure™ (Stratagene, La Jolla, Calif.) cells were sometimes used amplify plasmid DNA for sequencing. Plasmids were transformed into these cells using the manufacturers' procedures. DNA was sequenced using the Sequenase® 2.0 DNA sequencing kit purchased from U.S. Biochemical Corporation (Cleveland, Ohio). The plasmids described in Section 6, their respective divergence from WT cry3Bb sequence, the resulting amino acid changes and the protein structure site of the changes are listed in Table 11.

                                      TABLE 11                                     __________________________________________________________________________     DNA SEQUENCE CHANGES OF CRY3BB* GENES                                          AND RESULTING AMINO ACID SUBSTITUTIONS OF THE CRY3BB* PROTEINS                                                             Structural Site                    Plasmid                                                                             cry3Bb* DNA Sequence    Cry3Bb* Amino Acid Sequence                                                                   of Alteration                      __________________________________________________________________________     pEG1707                                                                             A460T, C461T, A462T, C464A, T465C, T466C, T467A,                                                       T154F, P155H, L156H, L158R                                                                    1α3,4                             A468T, A469T, G470C, T472C, T473G, G474T,                                      A477T, A478T, G479C                                                       pEG1708                                                                             T687C, T688C, A689T, C691A, A692G                                                                      Y230L, H231S   α6                           pEG1709                                                                             T667C, T687C, T688A, A689G, C691A, A692G                                                               S223P, Y230S   α6                           pEG1710                                                                             T687C, A692G            H231R          α6                           pEG1711                                                                             T687C, C691A            H231N, T241S   α6                           pEG1712                                                                             T687C, C691A, A692C, T693C                                                                             H231T          α6                           pEG1713                                                                             C868A, G869A, G870T     R290N          1α7,β1                  pEG1714                                                                             C932T, A938C, T942G, G949A, T954C                                                                      S311L, N313T, E317K                                                                           1β1,α8                  pEG1715                                                                             T931A, A933C, T942A, T945A, G949A, A953G,                                                              S311T, E317K, Y318C                                                                           1β1,α8                       T954C                                                                     PEG1716                                                                             T931G, A933C, C934G, T945G, C946T, A947G,                                                              S311A, L312V, Q316W                                                                           1β1,α8                       G951A, T954C                                                              pEG1717                                                                             T687C, A692G, C932T, A938C, T942G, G949A,                                                              H231R, S311L, N313T, E317K                                                                    α6, 1β1,α8             T954C                                                                     pEG1718                                                                             T931A, A933G, T935C, T936A, A938C, T939C,                                                              S311T, L312P, N313T, E317N                                                                    1β1,α8                       T942C, T945A, G951T, T954C                                                pEG1719                                                                             T931G, A933C, T936G, T942C, C943T, T945A,                                                              S311A, Q316D   1β1,α8                       C946G, G948C, T954C                                                       pEG1720                                                                             T861C, T866C, C868A, T871C, T872G, A875T,                                                              I289T, L291R, Y292F, S293R                                                                    1α7,β1                       T877A, C878G, A882G                                                       pEG1721                                                                             T687C, A692G, C932T     H231R, S311L   α6, 1β1, α8       pEG1722                                                                             T931A, C932T, A933C, T936C, T942G, T945A, T954C                                                        S311I          1β1,α8                  pEG1723                                                                             T931A, C932T, A933C, T936C, A937G, A938T,                                                              S311I, N313H   1β1,α8                       C941A, T942C, T945A, C946A, A947T, A950T,                                      T954C                                                                     pEG1724                                                                             A933C, T936C, A937G, A938T, C941A, T942C,                                                              N313V, T314N, Q316M, E317V                                                                    1β1,α8                       T945A, C946A, A947T, A950T, T954C                                         pEG1725                                                                             A933T, A938G, T939G, T942A, T944C, T945A,                                                              N313R, L315P, Q316L, E317A                                                                    1β1,α8                       A947T, G948T, A950C, T954C                                                pEG1726                                                                             A860T, T861C, G862A, C868T, G869T, T871C,                                                              Y287F, D288N, R290L                                                                           1α7,β1                       A873T, T877A, C878G, A879T                                                pEG1727                                                                             C868G, G869T            R290V          1α7,β1                  pEG1041                                                                             A494G                   D165G          α4                           pEG1046                                                                             G479A, A481C, A482C, A484C, G485A,                                                                     S160N, K161P, P162H, D165G                                                                    α4                                A486C, A494G                                                              pEG1047                                                                             A865G, T877C            I289V, S293P   1α7,β1                  pEG1052                                                                             G479A, A481C, A482C, A484C, G485A, A486C,                                                              S160N, K161P, P162H, D165G,                                                                   α4, 1α7,β1             A494G, A865G, T877C     I289V, S293P                                      pEG1054                                                                             T309A, Δ310, Δ311, Δ312                                                              D103E, ΔA104                                                                            1α2a,2b                      pEG1057                                                                             A565G, A566G            K189G          1α4,5                        pEG1062                                                                             T309A, Δ310, Δ311, Δ312, G479A, A481C,                                               D103E, ΔA104, S160N,                                                                    1α2a,2b α4                  A484C, G485A, A486C, A494G                                                                             P162H, D165G                                      pEG1063                                                                             T309A, Δ310, Δ311, Δ312, A460T, C461T,                                               D103E, ΔA104, T154F,                                                                    1α2a,2b 1α3,4               C464A, T465C, T466C, T467A, A468T, A469T,                                                              L156H, L158R                                           G470C, T472C, T473G, G474T, A477T, A478T,                                      G479C                                                                     pEG1084                                                                             A494G, T931A, A933C, T942A, T945A, G949A,                                                              D165G, S311T, E317K                                                                           α4, 1β1,α8             T954C                                                                     pEG1085                                                                             A494G, A865G, T877C, T914C, T931G, A933C,                                                              D165G, 1289V, S293P, F305S,                                                                   α4, 1α7,β1                                                    β1, 1β1,α8              C934G, T945G, C946T, A947G, G951A, T954C,                                                              S311A, L312V, Q316W, Q348R,                                                                   β2, β3b                       A1043G, T1094C          V365A                                             pEG1086                                                                             A865G, T877C, A1043G    1289V, S293P, Q348R                                                                           1α7,β1, β2         pEG1087                                                                             A494G, C932T            D165G, S311L   α4, 1β1,α8        pEG1095                                                                             A1043G                  Q348R          β2                            __________________________________________________________________________

5.27 Example 27

Expression of Cry3Bb* Proteins

5.27.1 Culture Conditions

LB agar was prepared using a standard formula (Maniatis et al., 1982). Starch agar was obtained from Difco Laboratories (Detroit, Mich.) and supplemented with an additional 5 g/l of agar. C2 liquid medium is described by Donovan et al. (1988). C2 medium was sometimes prepared without the phosphate buffer (C2-P). All cultures were incubated at 25° C. to 30° C.; liquid cultures were also shaken at 250 rpm, until sporulation and lysis had occurred.

5.27.2 Transformation Conditions

pEG1701 and derivatives thereof were introduced into acrystalliferious B. thuringiensis var. kurstaki EG7566 (Baum, 1994) or EG10368 (U.S. Pat. No. 5,322,687) by the electroporation method of Macaluso and Mettus (1991). In some cases, the method was modified as follows to maximize the number of transformants. The recipient B. thuringiensis strain was inoculated from overnight growth at 30° C. on LB agar into brain heart infusion plus 0.5% glycerol, grown to an optical density of approximately 0.5 at 600 nm, chilled on ice for 10 min, washed 2× with EB and resuspended in a 1/50 volume of EB. Transformed cells were selected on LB agar or starch agar plus 5 μg/ml chloramphenicol. Visual screening of colonies was used to identify transformants producing crystalline protein; those colonies were generally more opaque than colonies that did not produce crystalline protein.

5.27.3 Strain and Protein Designations

A transformant containing an altered cry3Bb* gene encoding an altered Cry3Bb* protein is designated by an "EG" number, e.g., EG11231. The altered Cry3Bb* protein is designated Cry3Bb followed by the strain number, e.g., Cry3Bb.11231. Collections of proteins with alterations at a structural site are designated Cry3Bb followed by the structural site, e.g., Cry3Bb.lβ2,3. Table 12 lists the plasmids pertinent to this invention, the new B. thuringiensis strains containing the plasmids, the acrystalliferous B. thuringiensis recipient strain used, and the proteins produced by the new strains.

5.28 Example 28

Generation and Characterization of Cry3Bb-60

5.28.1 Generation of Cry3Bb-60

Cry3Bb-producing strain EG7231 (U.S. Pat. No. 5,187,091) was grown in C2 medium plus 3 mg/ml chloramphenicol. Following sporulation and lysis, the culture was washed with water and Cry3Bb protein purified by the NaBr solubilization and recrystallization method of Cody et at. (1992). Protein concentration was determined by BCA Protein Assay (Pierce, Rockford, Ill.). Recrystallized protein was solubilized in 10 ml of 50 mM KOH per 100 mg of Cry3Bb protein and buffered to pH 9.0 with 100 mM CAPS (3-[cyclohexylamino]-1-propanesulfonic acid), pH 9.0. The soluble toxin was treated with trypsin at a weight ratio of 50 mg toxin to 1 mg trypsin for 20 min to overnight at room temperature. Trypsin cleaves proteins on the carboxyl side of available arginine and lysine residues. For 8-dose bioassay, the solubilization conditions were altered slightly to increase the concentration of protein: 50 mM KOH was added dropwise to 2.7 ml of a 12.77 mg/ml suspension of purified Cry3Bb* until crystal solubilization occurred. The volume was then adjusted to 7 ml with 100 mM CAPS, pH 9.0.

                  TABLE 12                                                         ______________________________________                                         PLASMIDS CARRYING ALTERED CRY3BB* GENES                                        TRANSFORMED INTO B. THURINGIENSIS                                              FOR EXPRESSION OF ALTERED CRY3BB* PROTEINS                                     Plasmid Designation                                                                       New BT Strain    Expressed Protein                                  ______________________________________                                         pEG1701    EG11204          WT Cry3Bb                                          pBG1701    EG11037          WT Cry3Bb                                          pEG1707    EG11221          Cry3Bb.11221                                       pBG1708    BG11222          Cry3Bb.11222                                       pEG1709    EG11223          Cry3Bb.11223                                       pEG1710    EG11224          Cry3Bb.11224                                       pEG1711    EG11225          Cry3Bb.11225                                       pEG1712    EG11226          Cry3Bb.11226                                       pEG1713    EG11227          Cry3Bb.11227                                       pEG1714    EGI1228          Cry3Bb.11228                                       pEG1715    EG11229          Cry3Bb.11229                                       pEG1716    EG11230          Cry3Bb.11230                                       pEG1717    EG11231          Cry3Bb.11231                                       pEG1718    EG11232          Cry3Bb.11232                                       pEG1719    EG11233          Cry3Bb.11233                                       pEG1720    EG11234          Cry3Bb.11234                                       pEG1721    EG11235          Cry3Bb.11235                                       pEG1722    EG11236          Cry3Bb.11236                                       pEG1723    EG11237          Cry3Bb.11237                                       pEG1724    EG11238          Cry3Bb.11238                                       pEG1725    EG11239          Cry3Bb.11239                                       pEG1726    EG11241          Cry3Bb.11241                                       pEG1727    EG11242          Cry3Bb.11242                                       pEG1041    EG11032          Cry3Bb.11032                                       pEG1046    EG11035          Cry3Bb.11035                                       pEG1047    EG11036          Cry3Bb.11036                                       pEG1052    EG11046          Cry3Bb.11046                                       pEG1054    EG11048          Cry3Bb.11048                                       pEG1057    EG11051          Cry3Bb.11051                                       pEG1062    EG11057          Cry3Bb.11057                                       pEG1063    EG11058          Cry3Bb.11058                                       pEG1084    EG11081          Cry3Bb.11081                                       pEG1085    EG11082          Cry3Bb.11082                                       pEG1086    EG11083          Cry3Bb.11083                                       pEG1087    EG11084          Cry3Bb.11084                                       pEG1095    EG11095          Cry3Bb.11095                                       pEG1098    EG11098          Cry3Bb.11098                                       pEG1701.1β2,3                                                                        collection of unnamed strains                                                                   Cry3Bb.1β2,3                                  pEG1701.1β6,7                                                                        collection of unnamed strains                                                                   Cry3Bb.1β6,7                                  pEG1701.1β10,11                                                                      collection of unnamed strains                                                                   Cry3Bb.1β10,11                                ______________________________________                                    

5.28.2 Determination of Molecular Weight of Cry3Bb-60

The molecular weight of the predominant trypsin digestion fragment of Cry3Bb was determined to be 60 kDa by SDS-polyacrylamide gel electrophoresis (SDS-PAGE) analysis using commercial molecular weight markers. This digestion fragment is designated Cry3Bb-60. No further digestion of the 60 kDa cleavage product was observed.

5.28.3 Determination of NH₂ -Terminus of Cry3Bb-60

To determine the NH₂ -terminal sequence of Cry3Bb-60, the trypsin digest was fractionated by SDS-PAGE and transferred to Immobilon TMP membrane (Millipore Corporation, Bedford, Mass.) following standard western blotting procedures. After transfer, the membrane was rinsed twice with water then stained with 0.025% Coomassie Brilliant Blue R-250 plus 40% methanol for 5 min, destained with 50% methanol and rinsed in water. The Cry3Bb.60 band was excised with a razor blade. NH₂ -terminal sequencing was performed at the Tufts Medical School, Department of Physiology (Boston, Mass.) using standard automated Edman degradation procedures. The NH₂ -terminal amino acid sequence was determined to be SKRSQDR (SEQ ID NO:96), corresponding to amino acids 160-166 of Cry3Bb. Trypsin digestion occurred on the carboxyl side of amino acid R159 resulting in the removal of helices 1-3.

5.29 Example 29

Bioactivity of Cry3Bb* Proteins

5.29.1 Culture Conditions and Protein Concentration Determination

Cultures for 1-dose bioassays were grown in C2-P plus 5 μg/ml chloramphenicol (C2-P/cm5) then diluted with 3 volumes of 0.005% Triton X-100®. The protein concentrations of these cultures were not determined. Cultures for 8-dose bioassays were grown in C2/cm5, washed 1-2 times with 1-2 volumes of sterile water and resuspended in 1/10 volume of sterile 0.005% Triton X-100®. The toxin protein concentration of each concentrate was determined as described by Brussock and Currier (1990), omitting the treatment with 3 M HEPES. The protein concentration was adjusted to 3.2 mg/ml in 0.005% Triton X-100® for the top dose of the assay. Cry3Bb.60 was produced and quantified for 8-dose assay as described in Section 9.1.

5.29.2 Insect Bioassays

Diabrotica undecimpunctata howardi Barber (southern corn rootworm or SCRW) and Diabrotica virgifera virgifiera LeConte (western corn rootworm or WCRW) larvae were reared as described by Slaney et al. (1992). Eight-dose assays and probit analyses were performed as described by Slaney et al. (1992). Thirty-two larvae were tested per dose at 50 μl of sample per well of diet (surface area of 175 mm²). Positive controls were WT Cry3Bb-producing strains EG11037 or EG11204. All bioassays were performed using 128-well trays containing approximately 1 ml of diet per well with perforated mylar sheet covers (C-D International Inc., Pitman, N.J.). One-dose assays were performed essentially the same except only 1 dose was tested per strain. All assay were replicated at least twice.

5.29.3 Insect Bioassay Results: 1-Dose Assays Against SCRW

Results from 1-dose assays are expressed as the relative mortality (RM) of the experimental strain compared to WT (% mortality of experimental culture divided by % mortality of WT culture). Altered and improved Cry3Bb proteins derived from plasmids constructed using PCR™ methods introducing random or semi-random changes into the cry3Bb gene sequence were distinguished from other altered but not improved Cry3Bb proteins by replicated, 1-dose assay against SCRW larvae. Those proteins showing increased activity (defined as RM≧1.5) compared to WT Cry3Bb or, in the case of proteins with combinations of altered sites, compared to a "parental" altered Cry3Bb protein were further characterized by 8-dose assay. The overall RM "pattern" produced by 1-dose assay results from a collection of proteins carrying random or semi-random alterations within a single structural region, e.g., in lβ2,3, can be used to determine if that structural region is important for bioactivity. Retention of WT levels of activity (RM≈1) indicate changes are tolerated in that region. Overall loss of activity (RM<1) distinguishes the region as important for bioactivity.

5.29.4 Cry3Bb.lβ2,3: Results of 1-Dose Bioassays Against SCRW

Cry3Bb.lβ2.3 protein are a collection of proteins altered in the lβ2,3 region of Cry3Bb (see Section 5.3.4). Typical results of 1-dose assays of these altered proteins are shown in FIG. 12. The RM values for Cry3Bb.lβ2,3 proteins are less than 1, with a few exceptions of values close to 1, indicating that this region is important for toxicity.

5.29.5 Cry3Bb.lβ6,7: Results of 1-Dose Bioassays Against SCRW

Cry3Bb.lβ6,7 proteins are a collection of proteins altered in the lβ6,7 region of Cry3Bb (see Section 5.3.5). Typical results of 1-dose assays of these altered proteins are shown in FIG. 13. With a few exceptions of values close to 1, the RM values for Cry3Bb.lβ6,7 proteins are less than 1, indicating that this region is important for toxicity.

5.29.6 Cry3Bb.lβ10,11: Results of 1-Dose Bioassays Against SCRW

Cry3Bb.lβ10,11 proteins are a collection of proteins altered in the lβ10,11 region of Cry3Bb (see Section 5.3.6). Typical results of 1-dose assays of these altered proteins are shown in FIG. 14. With a few exceptions of values close to 1, the RM values for Cry3Bb.lβ10,11 proteins are less than 1, indicating that this region is important for bioactivity.

5.29.7 Insect Bioassay Results: Results of 8-Dose Assays Against SCRW

Results from 8-dose assays are expressed as an LC₅₀ value (protein concentration giving 50% mortality) with 95% confidence intervals. The LC₅₀ values with 95% confidence intervals of altered Cry3Bb proteins showing improved activities against SCRW larvae and LC₅₀ values of the WT Cry3Bb control determined at the same time are listed in Table 13 along with the fold increase over WT activity for each improved protein.

                  TABLE 13                                                         ______________________________________                                         DESIGNED CRY3BB PROTEINS WERE TESTED AGAINST                                   SCRW LARVAE IN REPLICATED, 8-DOSE ASSAYS                                       TO DETERMINE THE LC.sub.50 VALUES                                                     LC.sub.50 μg/well (95% C.I.)                                                                           Fold                                         Improved              WT Cry3Bb   Increase Over                                Protein  Improved Protein                                                                            Control     WT Activity                                  ______________________________________                                         Cry3Bb.60                                                                               6.7    (5.3-8.4) 24.1 (15-39)                                                                               3.6×                               Cry3Bb.11221                                                                            3.2    (2.5-4)   20.5 (14.5-29)                                                                             6.4×                               Cry3Bb.11222                                                                            7.3    (6-9)     29.4 (23-37)                                                                               4.0×                               Cry3Bb.11223                                                                            10.5   (9-12)    29.4 (23-37)                                                                               2.8×                               Cry3Bb.11224                                                                            6.5    (5.1-8.2) 32.5 (25-43)                                                                               5.0×                               Cry3Bb.11225                                                                            13.7   (11-16.8) 49.5 (39-65)                                                                               3.6×                               Cry3Bb.11226                                                                            16.7   (10.6-24.2)                                                                              49.5 (39-65)                                                                               3.0×                               Cry3Bb.11227                                                                            11.1   (9.1-13.5)                                                                               21.3 (16-28)                                                                               1.9×                               Cry3Bb.11228                                                                            8.0    (6.6-9.8) 32.9 (25-45)                                                                               4.1×                               Cry3Bb.11229                                                                            7.2    (5.8-8.8) 18.2 (15-22)                                                                               2.5×                               Cry3Bb.11230                                                                            7.0    (5.8-8.6) 32.9 (25-45)                                                                               4.7×                               Cry3Bb.11231                                                                            3.3    (3.0-3.7) 26.1 (22-31)                                                                               7.9×                               Cry3Bb.11232                                                                            6.4    (5.4-7.7) 32.9 (25-45)                                                                               5.1×                               Cry3Bb.11233                                                                            15.7   (12-20)   32.9 (25-45)                                                                               2.2×                               Cry3Bb.11234                                                                            7      (6-9)     29   (22-39)                                                                               4.1×                               Cry3Bb.11235                                                                            4.2    (3.6-4.9) 13.3 (10-17)                                                                               3.2×                               Cry3Bb.11236                                                                            11.6   (9-15)    36.4 (27-49)                                                                               3.1×                               Cry3Bb.11237                                                                            6.8    (4-11)    36.4 (27-49)                                                                               5.4×                               Cry3Bb.11238                                                                            13.9   (11-17)   36.4 (27-49)                                                                               2.6×                               Cry3Bb.11239                                                                            13.0   (10-16)   36.4 (27-49)                                                                               2.8×                               Cry3Bb.11241                                                                            11     (7-16)    29   (22-39)                                                                               2.6×                               Cry3Bb.11242                                                                            11.9   (9.2-16)  30   (23-38)                                                                               2.5×                               Cry3Bb.11032                                                                            4.2    (3.6-4.9) 13.3 (10-17)                                                                               3.1×                               Cry3Bb.11035                                                                            10.3   (8-13)    27.9 (23-34)                                                                               2.7×                               Cry3Bb.11036                                                                            6.5    (5.1-7.9) 27.9 (23-34)                                                                               4.3×                               Cry3Bb.11046                                                                            12.1   (8-19)    31.2 (25-39)                                                                               2.6×                               Cry3Bb.11048                                                                            8.3    (6-11)    35.4 (24-53)                                                                               4.3×                               Cry3Bb.11051                                                                            11.8   (8-16)    35.4 (24-53)                                                                               3.0×                               Cry3Bb.11057                                                                            8.8    (7-11)    29.5 (24-36)                                                                               3.4×                               Cry3Bb.11058                                                                            9.6    (6-14)    33.4 (27-43)                                                                               3.5×                               Cry3Bb.11081                                                                            8.5    (7-11)    51.5 (37-79)                                                                               6.1×                               Cry3Bb.11082                                                                            10.6   (8-13)    51.5 (37-79)                                                                               4.9×                               Cry3Bb.11083                                                                            7.0    (5-10)    51.5 (37-79)                                                                               7.4×                               Cry3Bb.11084                                                                            7.2    (4-12)    51.5 (37-79)                                                                               7.2×                               Cry3Bb.11095                                                                            11.1   (9-14)    51.5 (37-79)                                                                               4.6×                               Cry3Bb.11098                                                                   ______________________________________                                    

5.29.8 Insect Bioassay Results: 8-Dose Assays Against WCRW

WCRW larvae are delicate and difficult to work with. Therefore, only some of the designed Cry3Bb showing improved activity against SCRW larvae were also tested against WCRW larvae in 8-dose assays. The LC₅₀ determinations for the designed Cry3Bb proteins are shown in Table 14 along with the LC₅₀ values of the WT Cry3Bb control determined at the same time.

                  TABLE 14                                                         ______________________________________                                         CRY3BB* PROTEINS SHOWING IMPROVED ACTIVITY                                     AGAINST SCRW LARVAE ALSO SHOW                                                  IMPROVED ACTIVITY AGAINST WCRW LARVAE                                                 LC.sub.50 μg/well (95% C.I.)                                                                           Fold                                         Improved              WT Cry3Bb   Increase Over                                Protein  Improved Protein                                                                            Control     WT Activity                                  ______________________________________                                         EG11083  6.3    (4.7-8.2) 63.5 (46-91)                                                                               10.1×                              EG11230  4.5    (2.1-7.4) 24.2 (13-40)                                                                                5.4×                              EG11231  2.5    (1.7-3.6) 32.2 (14-67)                                                                               12.9×                              ______________________________________                                    

5.30 Example 30

Channel Activity

Ion channels produced by Cry3Bb and some of its derivatives were measured by the methods described by Slatin et al. (1990). In some instances, lipid bilayers were prepared from a mixture of 4:1 phophatidylethanolamine (PE): phosphatidylcholine (PC). Toxin protein was solubilized from washed, C2 medium, B. thuringiensis cultures with 12 mM KOH. Following centrifugation to remove spores and other debris, 10 μg of soluble toxin protein was added to the cis compartment (4.5 ml volume) of the membrane chamber. Protein concentration was determined using the BCA Protein Assay (Pierce)

5.30.1 Channel Activity of WT Cry3Bb.

Upon exposure to black lipid membranes, Cry3Bb forms ion channels with various conductance states. The channels formed by Cry3Bb are rarely discrete channels with well resolved open and closed states and usually require incubation of the toxin with the membrane for 30-45 min before any channel-like events are observed. After formation of the initial conductances, the size increases from approximately 200 pS to over 10,000 pS over 2-3 h. Only the small conductances (≦200 pS) are voltage dependent. Over 200 pS, the conductances are completely symmetric. Cry3Bb channels also exhibit β-mercaptoethanol-dependent activation, growing from small channel conductances of ˜200 pS to several thousand pS within 2 min of the addition of β-mercaptoethanol to the cis compartment of the membrane chamber.

5.30.2 Cry3Bb.11032

The channel activity of Cry3Bb.11032 is much like WT Cry3Bb when the solubilized toxin protein is added to the cis compartment of the membrane chamber. However, when this protein is artificially incorporated into the membrane by forming or "painting" the membrane in the presence of the Cry3Bb.11032 protein, a 16-fold increase in the initial channel conductances is observed (˜4000 pS). This phenomenon is not observed with WT Cry3 Bb.

5.30.3 Cry3Bb.11035

Upon exposure to artificial membranes, the Cry3Bb.11035 protein spontaneously forms channels that grow to large conductances within a relatively short time span (˜5 min). Conductance values ranges from 3000-6000 pS and, like WT Cry3Bb, are voltage dependent at low conductance values.

5.30.4 Cry3Bb.11048

The Cry3Bb.11048 protein is quite different than WT Cry3Bb in that it appears not to form channels at all, but, rather, forms symmetrical pores with respect to voltage. Once the pore is formed, it remains open and allows a steady conductance ranging from 25 to 130 pS.

5.30.5 Cry3Bb.11224 and Cry3Bb.11226

The metal binding site of WT Cry3Bb formed by H231 in the dimer structure was removed in proteins Cry3Bb.11224 and Cry3Bb.11226. The conductances formed by both designed proteins are identical to that of WT Cry3Bb with the exception that neither of the designed proteins exhibits β-mercaptoethanol-dependent activation.

5.30.6 Cry3Bb.11221

Cry3Bb. 11221 protein has been observed to immediately form small channels of 100-200 pS with limited voltage dependence. Some higher conductances were observed at the negative potential. In other studies the onset of activity was delayed by 27 min, which is more typical for WT Cry3Bb. Unlike WT Cry3Bb, however, Cry3Bb.11221 forms well resolved, 600 pS channels with long open states. The protein eventually reaches conductances of 7000 pS.

5.30.7 Cry3Bb.11242

Cry3Bb.11242 protein forms small conductances immediately upon exposure to an artificial membrane. The conductances grow steadily and rapidly to 6000 pS in approximately 3 min. Some voltage dependence was noted with a preference for a negative imposed voltage.

5.30.8 Cry3Bb.11230

Unlike WT Cry3Bb, Cry3Bb.11230 forms well resolved channels with long open states that do not continue to grow in conductance with time. The maximum observed channel conductances reached 3000 pS. FIG. 15 illustrates the difference between the channels formed by Cry3Bb and Cry3Bb.11230.

5.30.9 Cry3Bb.60

Cry3Bb.60 forms well resolved ion channels within 20 min of exposure to an artificial membrane. These channels grow in conductance and frequency with time. The behavior of Cry3Bb.60 in a planar lipid bilayer differs from Cry3Bb in two significant ways. The conductances created by Cry3Bb.60 form more quickly than Cry3Bb and, unlike Cry3Bb, the conductances are stable, having well resolved open and closed states definitive of stable ion channels (FIG. 16).

5.31 Example 31

Primer Compositions

                  TABLE 15                                                         ______________________________________                                         SEQ ID NO: 83  % of Nucleotide in mixture                                      Code           A     T          G   C                                          ______________________________________                                         N              25    25         25  25                                         ______________________________________                                    

                  TABLE 16                                                         ______________________________________                                         SEQ ID NO: 84  % of Nucleotide in mixture                                      Code           A     T          G   C                                          ______________________________________                                         N              25    25         25  25                                         ______________________________________                                    

                  TABLE 17                                                         ______________________________________                                         SEQ ID NO: 85  % of Nucleotide in mixture                                      Code           A     T          G   C                                          ______________________________________                                         B              16    16         52  16                                         D              70    10         10  10                                         N              25    25         25  25                                         ______________________________________                                    

                  TABLE 18                                                         ______________________________________                                         SEQ ID NO: 86  % of Nucleotide in mixture                                      Code           A     T          G   C                                          ______________________________________                                         E              82     6          6   6                                         F               6     6          6  82                                         J               6    82          6   6                                         I               6     6         82   6                                         N              25    25         25  25                                         ______________________________________                                    

                  TABLE 19                                                         ______________________________________                                         SEQ ID NO: 88  % of Nucleotide in mixture                                      Code           A     T          G   C                                          ______________________________________                                         J               6    82          6   6                                         E              82     6          6   6                                         H               1     1          1  97                                         I               6     6         82   6                                         K              15    15         15  55                                         R              15    55         15  15                                         ______________________________________                                    

                  TABLE 20                                                         ______________________________________                                         SEQ ID NO: 90  % of Nucleotide in mixture                                      Code           A     T          G   C                                          ______________________________________                                         J               6    82          6   6                                         F               6     6          6  82                                         N              25    25         25  25                                         E              82     6          6   6                                         I               6     6         82   6                                         L               8     1         83   8                                         O               1     1          1  97                                         ______________________________________                                    

                  TABLE 21                                                         ______________________________________                                         SEQ ID NO: 91  % of Nucleotide in mixture                                      Code           A     T          G   C                                          ______________________________________                                         J               6    82          6   6                                         E              82     6          6   6                                         H               1     1          1  97                                         I               6     6         82   6                                         N              25    25         25  25                                         M              82     2          8   8                                         ______________________________________                                    

                  TABLE 22                                                         ______________________________________                                         SEQ ID NO: 92                                                                               % of Nucleotide in mixture                                        Code           A     T          G   C                                          ______________________________________                                         J               6    82          6   6                                         Q               0     9         82   9                                         F               6     6          6  82                                         N              25    25         25  25                                         E              82     6          6   6                                         I               6     6         82   6                                         ______________________________________                                    

                  TABLE 23                                                         ______________________________________                                         SEQ ID NO: 92                                                                               % of Nucleotide in mixture                                        Code           A     T          G   C                                          ______________________________________                                         J               6    82          6   6                                         F               6     6          6  82                                         N              25    25         25  25                                         E              82     6          6   6                                         I               6     6         82   6                                         ______________________________________                                    

                  TABLE 24                                                         ______________________________________                                         SEQ ID NO: 95                                                                               % of Nucleotide in mixture                                        Code           A     T          G   C                                          ______________________________________                                         J               6    82          6   6                                         N              25    25         25  25                                         E              82     6          6   6                                         I               6     6         82   6                                         M              82     2          8   8                                         P               8     2          8  82                                         S               1    97          1   1                                         ______________________________________                                    

5.32 Example 32

Atomic Coordinates for Cry3Bb

The atomic coordinates of the Cry3Bb protein are given in the Appendix included in Section 9.1

5.33 Example 33

Atomic Coordinates for Cry3A

The atomic coordinates of the Cry3A protein are given in the Appendix included in Section 9.2

5.34 Example-34

Modification of Cry Genes for Expression in Plants

Wild-type cry genes are known to be expressed poorly in plants as a full length gene or as a truncated gene. Typically, the G+C content of a cry gene is low (37%) and often contains many A+T rich regions, potential polyadenylation sites and numerous ATTTA sequences. Table 25 shows a list of potential polyadenylation sequences which should be avoided when preparing the "plantized" gene construct.

                  TABLE 25                                                         ______________________________________                                         LIST OF SEQUENCES OF THE                                                       POTENTIAL POLYADENYLATION SIGNALS                                              ______________________________________                                         AATAAA*              AAGCAT                                                    AATAAT*              ATTAAT                                                    AACCAA               ATACAT                                                    ATATAA               AAAATA                                                    AATCAA               ATTAAA**                                                  ATACTA               AATTAA**                                                  ATAAAA               AATACA**                                                  ATGAAA               CATAAA**                                                  ______________________________________                                          *indicates a potential major plant polyadenylation site.                       **indicates a potential minor animal polyadenylation site.                     All others are potential minor plant polyadenylation sites.              

The regions for mutagenesis may be selected in the following manner. All regions of the DNA sequence of the cry gene are identified which contained five or more consecutive base pairs which were A or T. These were ranked in terms of length and highest percentage of A+T in the surrounding sequence over a 20-30 base pair region. The DNA is analysed for regions which might contain polyadenylation sites or ATTTA sequences. Oligonucleotides are then designed which maximize the elimination of A+T consecutive regions which contained one or more polyadenylation sites or ATTTA sequences. Two potential plant polyadenylation sites have been shown to be more critical based on published reports. Codons are selected which increase G+C content, but do not generate restriction sites for enzymes useful for cloning and assembly of the modified gene (e.g., BamHI, BglII, SacI, NcoI, EcoRV, etc.). Likewise condons are avoided which contain the doublets TA or GC which have been reported to be infrequently-found codons in plants.

Although the CaMV35S promoter is generally a high level constitutive promoter in most plant tissues, the expression level of genes driven the CaMV35S promoter is low in floral tissue relative to the levels seen in leaf tissue. Because the economically important targets damaged by some insects are the floral parts or derived from floral parts (e.g., cotton squares and bolls, tobacco buds, tomato buds and fruit), it is often advantageous to increase the expression of crystal proteins in these tissues over that obtained with the CaMV35S promoter.

The b 35S promoter of Figwort Mosaic Virus (FMV) is analogous to the CaMV35S promoter. This promoter has been isolated and engineered into a plant transformation vector. Relative to the CaMV promoter, the FMV 35S promoter is highly expressed in the floral tissue, while still providing similar high levels of gene expression in other tissues such as leaf. A plant transformation vector, may be constructed in which the full length synthetic cry gene is driven by the FMV 35S promoter. Tobacco plants may be transformed with the vector and compared for expression of the crystal protein by Western blot or ELISA immunoassay in leaf and floral tissue. The FMV promoter has been used to produce relatively high levels of crystal protein in floral tissue compared to the CaMV promoter.

5.35 Example 35

Expression of Synthetic Cry Genes with ssRUBISCO Promoters and Chloroplast Transit Peptides

The genes in plants encoding the small subunit of RUBISCO (SSU) are often highly expressed, light regulated and sometimes show tissue specificity. These expression properties are largely due to the promoter sequences of these genes. It has been possible to use SSU promoters to express heterologous genes in transformed plants. Typically a plant will contain multiple SSU genes, and the expression levels and tissue specificity of different SSU genes will be different. The SSU proteins are encoded in the nucleus and synthesized in the cytoplasm as precursors that contain an N-terminal extension known as the chloroplast transit peptide (CTP). The CTP directs the precursor to the chloroplast and promotes the uptake of the SSU protein into the chloroplast. In this process, the CTP is cleaved from the SSU protein. These CTP sequences have been used to direct heterologous proteins into chloroplasts of transformed plants.

The SSU promoters might have several advantages for expression of heterologous genes in plants. Some SSU promoters are very highly expressed and could give rise to expression levels as high or higher than those observed with the CaMV35S promoter. The tissue distribution of expression from SSU promoters is different from that of the CaMV35S promoter, so for control of some insect pests, it may be advantageous to direct the expression of crystal proteins to those cells in which SSU is most highly expressed. For example, although relatively constituitive, in the leaf the CaMV35S promoter is more highly expressed in vascular tissue than in some other parts of the leaf, while most SSU promoters are most highly expressed in the mesophyll cells of the leaf. Some SSU promoters also are more highly tissue specific, so it could be possible to utilize a specific SSU promoter to express the protein of the present invention in only a subset of plant tissues, if for example expression of such a protein in certain cells was found to be deleterious to those cells. For example, for control of Colorado potato beetle in potato, it may be advantageous to use SSU promoters to direct crystal protein expression to the leaves but not to the edible tubers.

Utilizing SSU CTP sequences to localize crystal proteins to the chloroplast might also be advantageous. Localization of the B. thuringiensis crystal proteins to the chloroplast could protect these from proteases found in the cytoplasm. This could stabilize the proteins and lead to higher levels of accumulation of active toxin. cry genes containing the CTP could be used in combination with the SSU promoter or with other promoters such as CaMV35S.

5.36 Example 36

Targeting of Cry* Proteins to the Extracellular Space or Vacuole through the Use of Signal Peptides

The B. thuringiensis proteins produced from the synthetic genes described here are localized to the cytoplasm of the plant cell, and this cytoplasmic localization results in plants that are insecticidally effective. It may be advantageous for some purposes to direct the B. thuringiensis proteins to other compartments of the plant cell. Localizing B. thuringiensis proteins in compartments other than the cytoplasm may result in less exposure of the B. thuringiensis proteins to cytoplasmic proteases leading to greater accumulation of the protein yielding enhanced insecticidal activity. Extracellular localization could lead to more efficient exposure of certain insects to the B. thuringiensis proteins leading to greater efficacy. If a B. thuringiensis protein were found to be deleterious to plant cell function, then localization to a noncytoplasmic compartment could protect these cells from the protein.

In plants as well as other eukaryotes, proteins that are destined to be localized either extracellularly or in several specific compartments are typically synthesized with an N-terminal amino acid extension known as the signal peptide. This signal peptide directs the protein to enter the compartmentalization pathway, and it is typically cleaved from the mature protein as an early step in compartmentalization. For an extracellular protein, the secretory pathway typically involves cotranslational insertion into the endoplasmic reticulum with cleavage of the signal peptide occurring at this stage. The mature protein then passes through the Golgi body into vesicles that fuse with the plasma membrane thus releasing the protein into the extracellular space. Proteins destined for other compartments follow a similar path-way. For example, proteins that are destined for the endoplasmic reiculum or the Golgi body follow this scheme, but they are specifically retained in the appropriate compartment. In plants, some proteins are also targeted to the vacuole, another membrane bound compartment in the cytoplasm of many plant cells. Vacuole targeted proteins diverge from the above pathway at the Golgi body where they enter vesicles that fuse with the vacuole.

A common feature of this protein targeting is the signal peptide that initiates the compartmentalization process. Fusing a signal peptide to a protein will in many cases lead to the targeting of that protein to the endoplasmic reticulum. The efficiency of this step may depend on the sequence of the mature protein itself as well. The signals that direct a protein to a specific compartment rather than to the extracellular space are not as clearly defined. It appears that many of the signals that direct the protein to specific compartments are contained within the amino acid sequence of the mature protein. This has been shown for some vacuole targeted proteins, but it is not yet possible to define these sequences precisely. It appears that secretion into the extracellular space is the "default" pathway for a protein that contains a signal sequence but no other compartmentalization signals. Thus, a strategy to direct B. thuringiensis proteins out of the cytoplasm is to fuse the genes for synthetic B. thuringiensis genes to DNA sequences encoding known plant signal peptides. These fusion genes will give rise to B. thuringiensis proteins that enter the secretory pathway, and lead to extracellular secretion or targeting to the vacuole or other compartments. Signal sequences for several plant genes have been described. One such sequence is for the tobacco pathogenesis related protein PR1b has been previously described (Cornelissen et al, 1986). The PR1b protein is normally localized to the extracellular space. Another type of signal peptide is contained on seed storage proteins of legumes. These proteins are localized to the protein body of seeds, which is a vacuole like compartment found in seeds. A signal peptide DNA sequence for the β-subunit of the 7S storage protein of common bean (Phaseolus vulgaris), PvuB has been described (Doyle et al., 1986). Based on the published these published sequences, genes may be synthesized chemically using oligonucleotides that encode the signal peptides for PRlb and PvuB. In some cases to achieve secretion or compartmentalization of heterologous proteins, it may be necessary to include some amino acid sequence beyond the normal cleavage site of the signal peptide. This may be necessary to insure proper cleavage of the signal peptide.

5.37 Example 37

Isolation of Transgenic Maize Resistant to Diabrotica spp. Using Cry3Bb Variants

5.37.1 Plant Gene Construction

The expression of a plant gene which exists in double-stranded DNA form involves transcription of messenger RNA (mRNA) from one strand of the DNA by RNA polymerase enzyme, and the subsequent processing of the mRNA primary transcript inside the nucleus. This processing involves a 3' non-translated region which adds polyadenylate nucleotides to the 3' end of the RNA. Transcription of DNA into mRNA is regulated by a region of DNA usually referred to as the "promoter". The promoter region contains a sequence of bases that signals RNA polymerase to associate with the DNA and to initiate the transcription of mRNA using one of the DNA strands as a template to make a corresponding strand of RNA.

A number of promoters which are active in plant cells have been described in the literature. Such promoters may be obtained from plants or plant viruses and include, but are not limited to, the nopaline synthase (NOS) and octopine synthase (OCS) promoters (which are carried on tumor-inducing plasmids of Agrobacterium tumefaciens), the cauliflower mosaic virus (CaMV) 19S and 35S promoters, the light-inducible promoter from the small subunit of ribulose 1,5-bisphosphate carboxylase (ssRUBISCO, a very abundant plant polypeptide), and the Figwort Mosaic Virus (FMV) 35S promoter. All of these promoters have been used to create various types of DNA constructs which have been expressed in plants (see e.g., U.S. Pat. No. 5,463,175, specifically incorporated herein by reference).

The particular promoter selected should be capable of causing sufficient expression of the enzyme coding sequence to result in the production of an effective amount of protein. One set of preferred promoters are constitutive promoters such as the CaMV35S or FMV35S promoters that yield high levels of expression in most plant organs (U.S. Pat. No. 5,378,619, specifically incorporated herein by reference). Another set of preferred promoters are root enhanced or specific promoters such as the CaMV derived 4 as-1 promoter or the wheat POX1 promoter (U.S. Pat. No. 5,023,179, specifically incorporated herein by reference; Hertig et al., 1991). The root enhanced or specific promoters would be particularly preferred for the control of corn rootworm (Diabroticus spp.) in transgenic corn plants.

The promoters used in the DNA constructs (i.e. chimeric plant genes) of the present invention may be modified, if desired, to affect their control characteristics. For example, the CaMV35S promoter may be ligated to the portion of the ssRUBISCO gene that represses the expression of ssRUBISCO in the absence of light, to create a promoter which is active in leaves but not in roots. The resulting chimeric promoter may be used as described herein. For purposes of this description, the phrase "CaMV35S" promoter thus includes variations of CaMV35S promoter, e.g, promoters derived by means of ligation with operator regions, random or controlled mutagenesis, etc. Furthermore, the promoters may be altered to contain multiple "enhancer sequences" to assist in elevating gene expression.

The RNA produced by a DNA construct of the present invention also contains a 5' non-translated leader sequence. This sequence can be derived from the promoter selected to express the gene, and can be specifically modified so as to increase translation of the mRNA. The 5' non-translated regions can also be obtained from viral RNA's, from suitable eucaryotic genes, or from a synthetic gene sequence. The present invention is not limited to constructs wherein the non-translated region is derived from the 5' non-translated sequence that accompanies the promoter sequence.

For optimized expression in monocotyledenous plants such as maize, an intron should also be included in the DNA expression construct. This intron would typically be placed near the 5' end of the mRNA in untranslated sequence. This intron could be obtained from, but not limited to a set of introns consisting of the maize hsp70 intron (U.S. Pat. No. 5,424,412; specifically incorporated herein by reference) or the rice Act1 intron (McElroy et al., 1990). As shown below, the maize hsp70 intron is useful in the present invention.

As noted above, the 3' non-translated region of the chimeric plant genes of the present invention contains a polyadenylation signal which functions in plants to cause the addition of adenylate nucleotides to the 3' end of the RNA. Examples of preferred 3' regions are (1) the 3' transcribed, non-translated regions containing the polyadenylate signal of Agrobacterium tumor-inducing (Ti) plasmid genes, such as the nopaline synthase (NOS) gene and (2) plant genes such as the pea ssRUBISCO E9 gene (Fischhoffet al., 1987).

5.37.2 Plant Transformation and Expression

A chimeric plant gene containing a structural coding sequence of the present invention can be inserted into the genome of a plant by any suitable method. Suitable plant transformation vectors include those derived from a Ti plasmid of Agrobacterium tumefaciens, as well as those disclosed, e.g., by Herrera-Estrella (1983), Bevan (1983), Klee (1985) and Eur. Pat. Appl. Publ. No. EP0120516. In addition to plant transformation vectors derived from the Ti or root-inducing (Ri) plasmids of Agrobacterium, alternative methods can be used to insert the DNA constructs of this invention into plant cells. Such methods may involve, for example, the use of liposomes, electroporation, chemicals that increase free DNA uptake, free DNA delivery via microprojectile bombardment, and transformation using viruses or pollen (Fromm et al., 1986; Armstrong et al., 1990; Fromm et a., 1990).

5.37.3 Construction of Monocot Plant Expression Vectors for Cry3Bb Variants 5.37.3.1 Design of Cry3Bb Variant Genes for Plant Expression

For efficient expression of the cry3Bb variants in transgenic plants, the gene encoding the variants must have a suitable sequence composition (Diehn et al., 1996). One example of such a sequence is shown for the v11231 gene (SEQ ID NO:99) which encodes the Cry3Bb11231 variant protein (SEQ ID NO:100) with Diabrotica activity. This gene was derived via mutagenesis (Kunkel, 1985) of a cry3Bb synthetic gene (SEQ ID NO:101) encoding a protein essentially homologous to the protein encoded by the native cry3Bb gene (Gen Bank Accession Number m89794, SEQ ID NO:102). The following oligonucleotides were used in the mutagenesis of the original cry3Bb synthetic gene (SEQ ID NO:101) to create the v11231 gene (SEQ ID NO:99):

Oligo #1:

5'-TAGGCCTCCATCCATGGCAAACCCTAACAATC-3' (SEQ ID NO:103)

Oligo #2:

5'-TCCCATCTTCCTACTTACGACCCTGCAGAAATACGGTCCAAC -3' (SEQ ID NO:104)

Oligo #3:

5'-GACCTCACCTACCAAACATTCGATCTTG-3' (SEQ ID NO:105)

Oligo #4:

5'-CGAGTTCTACCGTAGGCAGCTCAAG-3' (SEQ ID NO:106)

5.37.3.2 Construction of Cry3Bb Monocot Plant Expression Vector

To place the cry3Bb variant gene v11231 in a vector suitable for expression in monocotyledonous plants (i.e. under control of the enhanced Cauliflower Mosaic Virus 35S promoter and link to the hsp70 intron followed by a nopaline synthase polyadenylation site as in U.S. Pat. No. 5,424,412, specifically incorporated herein by reference), the vector pMON19469 was digested with NcoI and EcoRI. The larger vector band of approximately 4.6 kb was electrophoresed, purified, and ligated with T4 DNA ligase to the NcoI-EcoRI fragment of approximately 2 kb containing the v11231 gene (SEQ ID NO:99). The ligation mix was transformed into E. coli, carbenicillin resistant colonies recovered and plasmid DNA recovered by DNA miniprep procedures. This DNA was subjected to restriction endonuclease analysis with enzymes such as NcoI and EcoRI (together), NotI, and PstI to identify clones containing pMON33708 (the v11231 coding sequence fused to the hsp70 intron under control of the enhanced CaMV35S promoter).

To place the v11231 gene in a vector suitable for recovery of stably transformed and insect resistant plants, the 3.75-kb NotI restriction fragment from pMON33708 containing the lysine oxidase coding sequence fused to the hsp70 intron under control of the enhanced CaMV35S promoter was isolated by gel electrophoresis and purification. This fragment was ligated with pMON30460 treated with NotI and calf intestinal alkaline phosphatase (pMON30460 contains the neomycin phosphotransferase coding sequence under control of the CaMV35S promoter). Kanamycin resistant colonies were obtained by transformation of this ligation mix into E. coli and colonies containing pMON33710 identified by restriction endonuclease digestion of plasmid miniprep DNAs. Restriction enzymes such as NotI, EcoRV, HindIII, NcoI, EcoRI, and BglII can be used to identify the appropriate clones containing the NotI fragment of pMON33708 in the NotI site of pMON30460 (i.e. pMON33710) in the orientation such that both genes are in tandem (i.e. the 3' end of the v11231 expression cassette is linked to the 5' end of the nptII expression cassette). Expression of the v11231 protein by pMON33710 in corn protoplasts was confirmed by electroporation of pMON33710 DNA into protoplasts followed by protein blot and ELISA analysis. This vector can be introduced into the genomic DNA of corn embryos by particle gun bombardment followed by paromomycin selection to obtain corn plants expressing the v11231 gene essentially as described in U.S. Pat. No. 5,424,412, specifically incorporated herein by reference.

In this example, the vector was introduced via cobombardment with a hygromycin resistance conferring plasmid into immature embryo scutella (IES) of maize, followed by hygromycin selection, and regeneration. Transgenic corn lines expressing the v11231 protein were identified by ELISA analysis. Progeny seed from these events were subsequently tested for protection from Diabrotica feeding.

5.37.3.3 In Planta Performace of Cry3Bb.11231

Transformed corn plants expressing Cry3Bb.11231 protein were challenged with western corn rootworm (WCR) larvae in both a seedling and 10 inch pot assay. The transformed genotype was A634, where the progeny of the RO cross by A634 was evaluated. Observations included effect on larval development (weight), root damage rating (RDR), and protein expression. The transformation vector containing the cry3Bb gene was pMON33710. Treatments included the positive and negative iso-populations for each event and an A634 check.

The seedling assay consisted of the following steps: (i) single seeds were placed in 1 oz cups containing potting soil; (ii) at spiking, each seedling was infested with 4 neonate larvae; and (iii) after infestation, seedlings were incubated for 7 days at 25° C., 50% RH, and 14:10 (L:D) photo period. Adequate moisture was added to the potting soil during the incubation period to maintain seedling vigor.

The 10 inch pot assay consisted of the following steps: (i) single seeds were placed in 10 inch pots containing potting soil; (ii) at 14 days post planting, each pot was infested with 800 eggs which have been pre-incubated such that hatch would occur 5-7 days post infestation; and (iii) after infestation, plants were incubated for 4 weeks under the same environmental conditions as the seedling assay. Pots were both sub and top irrigated daily.

For the seedling assay, on day 7 plants were given a root damage rating, and surviving larvae were weighed. Also at this time, Cry3Bb protein concentrations in the roots were determined by ELISA. The scale used for the seedling assay to assess root damage is as follows: RDR (root damage rating) 0=no visible feeding; RDR 1=very light feeding; RDR 2=light feeding; RDR 3=moderate feeding; RDR 4=heavy feeding; and RDR 5 =very heavy feeding.

Results of the seedling assay are shown in Table 26. Plants expressing Cry3Bb protein were completely protected by WCR feeding, where surviving larvae within this treatment had not grown. Mean larval weights ranged from 2.03-2.73 mg for the nonexpressing treatments, where the surviving larval average weight was 0.11 mg on the expressing cry3Bb treatment. Root damage ratings were 3.86 and 0.33 for the nonexpressing and expressing isopopulations, respectively. Larval survival ranged from 75-85% for the negative and check treatments, where only 25% of the larvae survived on the Cry3Bb treatment.

                  TABLE 26                                                         ______________________________________                                         EFFECT OF CRY3BB EXPRESSING PLANTS ON                                          WCR LARVAE IN A SEEDLING ASSAY                                                         Plants        Larvae                                                                       Root              %    Mean ± SD                        Event                                                                               Treatment                                                                               N     (ppm) RDR ± SD                                                                            N   Surv Wt. (mg)                            ______________________________________                                         16   Negative 7     0.0   3.86 ± 0.65                                                                         21  75   2.73 ± 1.67                      16   Positive 3     29.01 0.33 ± 0.45                                                                          3  25   0.11 ± 0.07                      A634 Check    4     0.0   --      13  81   2.03 ± 0.83                      ______________________________________                                    

For the 10 inch pot assay, at 4 weeks post infestation plant height was recorded and a root damage rating (Iowa 1-6 scale; Hills and Peters, 1971) was given.

Results of the 10 inch pot assay are shown in Table 27. Plants expressing Cry3Bb protein had significantly less feeding damage and were taller than the non-expressing plants. Event 16, the higher of the two expressing events provided nearly complete control. The negative treatments had very high root damage ratings indicating very high insect pressure. The positive mean root damage ratings were 3.4 and 2.2 for event 6 and 16, respectively. Mean RDR for the negative treatment was 5.0 and 5.6.

                  TABLE 27                                                         ______________________________________                                         EFFECT OF CRY3BB EXPRESSING CORN IN CONTROLLING                                WCR LARVAL FEEDING IN A 10 INCH POT ASSAY                                                             Root            Plant Height                            Event Treatment                                                                               N       (ppm) RDR ± SD                                                                              (cm)                                    ______________________________________                                          6    Negative 7       0.0   5.0 ± 1.41                                                                            49.7 ± 18.72                          6    Positive 5       7.0   3.4 ± 1.14                                                                            73.9 ± 8.67                          16    Negative 5       0.0   5.6 ± 0.89                                                                            61.2 ± 7.75                          16    Positive 5       55.0  2.2 ± 0.84                                                                            83.8 ± 7.15                          ______________________________________                                    

In summary, corn plants expressing Cry3Bb protein have a significant biological effect on WCR larval development as seen in the seedling assay. When challenged with very high infestation levels, plants expressing the Cry3Bb protein were protected from WCR larval feeding damage as illustrated in the 10 inch pot assay.

6.0 BRIEF DESCRIPTION OF THE SEQUENCE IDENTIFIERS

SEQ ID NO:1 DNA sequence of cry3Bb.11221 gene.

SEQ ID NO:2 Amino acid sequence of Cry3Bb.11221 polypeptide.

SEQ ID NO:3 DNA sequence of cry3Bb.11222 gene.

SEQ ID NO:4 Amino acid sequence of Cry3Bb.11222 polypeptide.

SEQ ID NO:5 DNA sequence of cry3Bb.11223 gene.

SEQ ID NO:6 Amino acid sequence of Cry3Bb.11223 polypeptide.

SEQ ID NO:7 DNA sequence of cry3Bb.11224 gene.

SEQ ID NO:8 Amino acid sequence of Cry3Bb.11224 polypeptide.

SEQ ID NO:9 DNA sequence of cry3Bb.11225 gene.

SEQ ID NO:10 Amino acid sequence of Cry3Bb.11225 polypeptide.

SEQ ID NO:11 DNA sequence of cry3Bb.11226 gene.

SEQ ID NO:12 Amino acid sequence of Cry3Bb.11226 polypeptide.

SEQ ID NO:13 DNA sequence of cry3Bb.11227 gene.

SEQ ID NO:14 Amino acid sequence of Cry3Bb.11227 polypeptide.

SEQ ID NO:15 DNA sequence of cry3Bb.11228 gene.

SEQ ID NO:16 Amino acid sequence of Cry3Bb.11228 polypeptide.

SEQ ID NO:17 DNA sequence of cry3Bb.11229 gene.

SEQ ID NO:18 Amino acid sequence of Cry3Bb.11229 polypeptide.

SEQ ID NO:19 DNA sequence of cry3Bb.11230 gene.

SEQ ID NO:20 Amino acid sequence of Cry3Bb.11230 polypeptide.

SEQ ID NO:21 DNA sequence of cry3Bb.11231 gene.

SEQ ID NO:22 Amino acid sequence of Cry3Bb.11231 polypeptide.

SEQ ID NO:23 DNA sequence of cry3Bb.11232 gene.

SEQ ID NO:24 Amino acid sequence of Cry3Bb.11232 polypeptide.

SEQ ID NO:25 DNA sequence of cry3Bb.11233 gene.

SEQ ID NO:26 Amino acid sequence of Cry3Bb.11233 polypeptide.

SEQ ID NO:27 DNA sequence of cry3Bb.11234gene.

SEQ ID NO:28 Amino acid sequence of Cry3Bb.11234 polypeptide.

SEQ ID NO:29 DNA sequence of cry3Bb.1235 gene.

SEQ ID NO:30 Amino acid sequence of Cry3Bb.11235 polypeptide.

SEQ ID NO:31 DNA sequence of cry3Bb.1236 gene.

SEQ ID NO:32 Amino acid sequence of Cry3Bb.11236 polypeptide.

SEQ ID NO:33 DNA sequence of cry3Bb.11237 gene.

SEQ ID NO:34 Amino acid sequence of Cry3Bb.11237 polypeptide.

SEQ ID NO:35 DNA sequence of cry3Bb.1238 gene.

SEQ ID NO:36 Amino acid sequence of Cry3Bb.11238 polypeptide.

SEQ ID NO:37 DNA sequence of cry3Bb.11239 gene.

SEQ ID NO:38 Amino acid sequence of Cry3Bb.11239 polypeptide.

SEQ ID NO:39 DNA sequence of cry3Bb.11241 gene.

SEQ ID NO:40 Amino acid sequence of Cry3Bb.11241 polypeptide.

SEQ ID NO:41 DNA sequence of cry3Bb.11242 gene.

SEQ ID NO:42 Amino acid sequence of Cry3Bb.11242 polypeptide.

SEQ ID NO:43 DNA sequence of cry3Bb.11032 gene.

SEQ ID NO:44 Amino acid sequence of Cry3Bb.11032 polypeptide.

SEQ ID NO:45 DNA sequence of cry3Bb.11035 gene.

SEQ ID NO:46 Amino acid sequence of Cry3Bb.11035 polypeptide.

SEQ ID NO:47 DNA sequence of cry3Bb.11036 gene.

SEQ ID NO:48 Amino acid sequence of Cry3Bb.11036 polypeptide.

SEQ ID NO:49 DNA sequence of cry3Bb.11046 gene.

SEQ ID NO:50 Amino acid sequence of Cry3Bb.11046 polypeptide.

SEQ ID NO:51 DNA sequence of cry3Bb.11048 gene.

SEQ ID NO:52 Amino acid sequence of Cry3Bb.11048 polypeptide.

SEQ ID NO:53 DNA sequence of cry3Bb.11051 gene.

SEQ ID NO:54 Amino acid sequence of Cry3Bb.11051 polypeptide.

SEQ ID NO:55 DNA sequence of cry3Bb.11057 gene.

SEQ ID NO:56 Amino acid sequence of Cry3Bb.11057 polypeptide.

SEQ ID NO:57 DNA sequence of cry3Bb.11058 gene.

SEQ ID NO:58 Amino acid sequence of Cry3Bb.11058 polypeptide.

SEQ ID NO:59 DNA sequence of cry3Bb.11081 gene.

SEQ ID NO:60 Amino acid sequence of Cry3Bb.11081 polypeptide.

SEQ ID NO:61 DNA sequence of cry3Bb.11082 gene.

SEQ ID NO:62 Amino acid sequence of Cry3Bb.11082 polypeptide.

SEQ ID NO:63 DNA sequence of cry3Bb.11083 gene.

SEQ ID NO:64 Amino acid sequence of Cry3Bb.11083 polypeptide.

SEQ ID NO:65 DNA sequence of cry3Bb.11084 gene.

SEQ ID NO:66 Amino acid sequence of Cry3Bb.11084 polypeptide.

SEQ ID NO:67 DNA sequence of cry3Bb.11095 gene.

SEQ ID NO:68 Amino acid sequence of Cry3Bb.11095 polypeptide.

SEQ ID NO:69 DNA sequence of cry3Bb.60 gene.

SEQ ID NO:70 Amino acid sequence of Cry3Bb.60 polypeptide.

SEQ ID NO:71 Primer FW001.

SEQ ID NO:72 Primer FW006.

SEQ ID NO:73 Primer MVT095.

SEQ ID NO:74 Primer MVT097.

SEQ ID NO:75 Primer MVT091.

SEQ ID NO:76 Primer MVT075.

SEQ ID NO:77 Primer MVT076.

SEQ ID NO:78 Primer MVT111.

SEQ ID NO:79 Primer MVT094.

SEQ ID NO:80 Primer MVT103.

SEQ ID NO:81 Primer MVT081.

SEQ ID NO:82 Primer MVT085.

SEQ ID NO:83 Primer A.

SEQ ID NO:84 Primer B.

SEQ ID NO:85 Primer C.

SEQ ID NO:86 Primer D.

SEQ ID NO:87 Primer E.

SEQ ID NO:88 Primer F.

SEQ ID NO:89 Primer G.

SEQ ID NO:90 Primer WD112.

SEQ ID NO:91 Primer WD115.

SEQ ID NO:92 Primer MVT105.

SEQ ID NO:93 Primer MVT092.

SEQ ID NO:94 Primer MVT070.

SEQ ID NO:95 Primer MVT083.

SEQ ID NO:96 N-terminal amino acid of Cry3Bb polypeptide.

SEQ ID NO:97 DNA sequence of wild-type cry3Bb gene.

SEQ ID NO:98 Amino acid sequence of wild-type Cry3Bb polypeptide.

SEQ ID NO:99 Plantized DNA sequence for cry3Bb.11231 gene.

SEQ ID NO:100 Amino acid sequence of plantized Cry3Bb.11231 polypeptide.

SEQ ID NO:101 DNA sequence of cry3Bb gene used to prepare SEQ ID NO:99.

SEQ ID NO:102 DNA sequence of wild-type cry3Bb gene, Genbank #M89794.

SEQ ID NO:103 DNA sequence of Oligo #1.

SEQ ID NO:104 DNA sequence of Oligo #2.

SEQ ID NO:105 DNA sequence of Oligo #3.

SEQ ID NO:106 DNA sequence of Oligo #4.

SEQ ID NO:107 DNA sequence of cry3Bb.11098 gene.

SEQ ID NO:108 Amino acid sequence of Cry3Bb.11098 polypeptide.

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    __________________________________________________________________________     8.0 APPENDIX                                                                   __________________________________________________________________________     8.1 CRYSTAL COORDINATES OF CRY3BB                                              HEADER   TOXIN         01-DEC-94                                               COMPND   DELTA ENDOTOXIN CRYIIIB2                                              SOURCE   (BACILLUS THURINGIENSIS, SUBSPECIES KUMAMOTOENSIS)                    AUTHOR   N. GALITSKY, V. CODY                                                  REVDAT                                                                               1  01-DEC-94                                                             REMARK                                                                               1                                                                        REMARK                                                                               1  REFERENCE 1                                                           REMARK                                                                               1  AUTH                                                                               NIKOLAI GALITSKY, VIVIAN CODY, ANDREZEJ WOJTCZAK,                 REMARKS                                                                              1  AUTH                                                                               DEBASHIS GHOSH, JOSEPH R. LUFT, WALTER PANGBORN,                  REMARKS                                                                              1  AUTH                                                                               ZDZISLAW WAWRZAK AND LEIGH ENGLISH.                               REMARK                                                                               1  TITL                                                                               CRYSTAL AND MOLECULAR STRUCTURE OF THE BACTERIRIAL                REMARK                                                                               1  TITL 2                                                                             DELTA-ENDOTOXIN CRYIIIB2.                                         REMARK                                                                               1  REF                                                                   REMARK                                                                               1  REFN                                                                  REMARK                                                                               1  REFERENCE 2                                                           REMARK                                                                               1  AUTH                                                                               CODY, V., LUFT, J. R., JENSEN, E., PANGBORG, W., &                REMARKS                                                                              1  AUTH                                                                               ENGLISH, L.                                                       REMARK                                                                               1  TITL                                                                               PURIFICATION AND CRYSTALLIZATION OF INSECTICIDAL                  REMARKS                                                                              1  TITL 1                                                                             DELTA-ENDOTOXIN CRYIIIB2 FROM BACILLUS THURINGIENSIS              REMARK                                                                               1  REF PROTEINS: STRUC. FUNC. GENETICS, (1992), 14, 324.                 REMARK                                                                               2                                                                        REMARK                                                                               2                                                                        REMARK                                                                               2  RESOLUTION. 2.4 ANGSTROMS.                                            REMARK                                                                               3                                                                        REMARK                                                                               3                                                                        REMARK                                                                               3  REFINEMENT.                                                           REMARK                                                                               3  PROGRAM         X-PLOR                                                REMARK                                                                               3  AUTHORS         BRUNGER                                               REMARK                                                                               3  R VALUE         0.18                                                  REMARK                                                                               3  RFREE VALUE     0.253                                                 REMARK                                                                               3  RMSD BOND DISTANCES                                                                            0.009 ANGSTROMS                                       REMARK                                                                               3  RMSD BOND ANGLES                                                                               1.30 DEGREES                                          REMARK                                                                               3                                                                        REMARK                                                                               3  NUMBER OF REFLECTIONS                                                                          29069                                                 REMARK                                                                               3  RESOLUTION RANGE                                                                               8.0-2.4 ANGSTROMS                                     REMARK                                                                               3  DATA CUTOFF     2.0 SIGMA(F)                                          REMARK                                                                               3                                                                        REMARK                                                                               3  NUMBER OF PROTEIN ATOMS                                                                        4750                                                  REMARK                                                                               3  NUMBER OF SOLVENT ATOMS                                                                        251                                                   REMARK                                                                               3                                                                        REMARK                                                                               3  THE ATOMIC MODEL INCLUDES RESIDUES 64-652 OF THE PROTEIN              REMARK                                                                               3  AND 251 BOUND WATER MOLECULES.                                        REMARK                                                                               3                                                                        REMARK                                                                               4                                                                        REMARK                                                                               4  Bacllius thuringiensis (Bt) is a gram-positive soil                   REMARK                                                                               4  bacterium characterized by its ability to produce                     REMARK                                                                               4  crystalline inclusions during sporulation which consist of            REMARK                                                                               4  proteins exhibiting a highly specific insecticidal activity           REMARK                                                                               4  There are a variety of toxins present in Bt which have                REMARK                                                                               4  different charactistics, for example, a-exotoxin                      REMARK                                                                               4  (phospholipase C) and d-endotoxin (the crystal protein).              REMARK                                                                               4                                                                        REMARK                                                                               5                                                                        REMARK                                                                               6  REMARK 6 HERE RESULTED FROM LAST REFINEMENT.                          REMARK                                                                               6  R = 18.0%, Rfree = 24.3% by X-PLOR                                    REMARK                                                                               6                                                                        SEQRES                                                                               1  ASP                                                                               ALA                                                                               VAL                                                                               GLY                                                                               THR                                                                               GLY                                                                               ILE                                                                               SER                                                                               VAL                                                                               VAL                                                                               GLY                                                                               GLN                                                                               ILE                               SEQRES                                                                               2  LEU                                                                               GLY                                                                               VAL                                                                               VAL                                                                               GLY                                                                               VAL                                                                               PRO                                                                               PHE                                                                               ALA                                                                               GLY                                                                               ALA                                                                               LEU                                                                               THR                               SEQRES                                                                               3  SER                                                                               PHE                                                                               TYR                                                                               GLN                                                                               SER                                                                               PHE                                                                               LEU                                                                               ASN                                                                               THR                                                                               ILE                                                                               TRP                                                                               PRO                                                                               SER                               SEQRES                                                                               4  ASP                                                                               ALA                                                                               ASP                                                                               PRO                                                                               TRP                                                                               LYS                                                                               ALA                                                                               PHE                                                                               MET                                                                               ALA                                                                               GLN                                                                               VAL                                                                               GLU                               SEQRES                                                                               5  VAL                                                                               LEU                                                                               ILE                                                                               ASP                                                                               LYS                                                                               LYS                                                                               ILE                                                                               GLU                                                                               GLU                                                                               TYR                                                                               ALA                                                                               LYS                                                                               SER                               SEQRES                                                                               6  LYS                                                                               ALA                                                                               LEU                                                                               ALA                                                                               GLU                                                                               LEU                                                                               GLN                                                                               GLY                                                                               LEU                                                                               GLN                                                                               ASN                                                                               ASN                                                                               PHE                               SEQRES                                                                               7  GLU                                                                               ASP                                                                               TYR                                                                               TYR                                                                               VAL                                                                               ASN                                                                               VAL                                                                               LEU                                                                               ASN                                                                               TRP                                                                               LYS                                                                               LYS                                                                               THR                               SEQRES                                                                               8  PRO                                                                               LEU                                                                               SER                                                                               LEU                                                                               ARG                                                                               SER                                                                               LYS                                                                               ARG                                                                               SER                                                                               GLN                                                                               ASP                                                                               ARG                                                                               ILE                               SEQRES                                                                               9  ARG                                                                               GLU                                                                               LEU                                                                               PHE                                                                               SER                                                                               GLN                                                                               ALA                                                                               GLU                                                                               SER                                                                               HIS                                                                               PHE                                                                               PHE                                                                               ARG                               SEQRES                                                                               10 ASN                                                                               SER                                                                               MET                                                                               PRO                                                                               SER                                                                               PHE                                                                               ALA                                                                               VAL                                                                               SER                                                                               LYS                                                                               PHE                                                                               GLU                                                                               VAL                               SEQRES                                                                               11 LEU                                                                               PHE                                                                               LEU                                                                               PRO                                                                               THR                                                                               TYR                                                                               ALA                                                                               GLN                                                                               ALA                                                                               ALA                                                                               ASN                                                                               THR                                                                               HIS                               SEQRES                                                                               12 LEU                                                                               LEU                                                                               LEU                                                                               LEU                                                                               LYS                                                                               ASP                                                                               ALA                                                                               GLN                                                                               VAL                                                                               PHE                                                                               GLY                                                                               GLU                                                                               GLU                               SEQRES                                                                               13 TRP                                                                               GLY                                                                               TYR                                                                               SER                                                                               SER                                                                               GLU                                                                               ASP                                                                               VAL                                                                               ALA                                                                               GLU                                                                               PHE                                                                               TYR                                                                               HIS                               SEQRES                                                                               14 ARG                                                                               GLN                                                                               LEU                                                                               LYS                                                                               LEU                                                                               THR                                                                               GLN                                                                               GLN                                                                               TYR                                                                               THR                                                                               ASP                                                                               HIS                                                                               CYS                               SEQRES                                                                               15 VAL                                                                               ASP                                                                               TRP                                                                               TYR                                                                               ASN                                                                               VAL                                                                               GLY                                                                               LEU                                                                               ASN                                                                               GLY                                                                               LEU                                                                               ARG                                                                               GLY                               SEQRES                                                                               16 SER                                                                               THR                                                                               TYR                                                                               ASP                                                                               ALA                                                                               TRP                                                                               VAL                                                                               LYS                                                                               PHE                                                                               ASN                                                                               ARG                                                                               PHE                                                                               ARG                               SEQRES                                                                               17 ARG                                                                               GLU                                                                               MET                                                                               THR                                                                               LEU                                                                               THR                                                                               VAL                                                                               LEU                                                                               ASP                                                                               LEU                                                                               ILE                                                                               VAL                                                                               LEU                               SEQRES                                                                               18 PHE                                                                               PRO                                                                               PHE                                                                               TYR                                                                               ASP                                                                               ILE                                                                               ARG                                                                               LEU                                                                               TYR                                                                               SER                                                                               LYS                                                                               GLY                                                                               VAL                               SEQRES                                                                               19 LYS                                                                               THR                                                                               GLU                                                                               LEU                                                                               THR                                                                               ARG                                                                               ASP                                                                               ILE                                                                               PHE                                                                               THR                                                                               ASP                                                                               PRO                                                                               ILE                               SEQRES                                                                               20 PHE                                                                               SER                                                                               ILE                                                                               ASN                                                                               THR                                                                               LEU                                                                               GLN                                                                               GLU                                                                               TYR                                                                               GLY                                                                               PRO                                                                               THR                                                                               PHE                               SEQRES                                                                               21 LEU                                                                               SER                                                                               ILE                                                                               GLU                                                                               ASN                                                                               SER                                                                               ILE                                                                               ARG                                                                               LYS                                                                               PRO                                                                               HIS                                                                               LEU                                                                               PHE                               SEQRES                                                                               22 ASP                                                                               TYR                                                                               LEU                                                                               GLN                                                                               GLY                                                                               ILE                                                                               GLU                                                                               PHE                                                                               THR                                                                               ARG                                                                               LEU                                                                               GLN                                                                               PRO                               SEQRES                                                                               23 GLY                                                                               TYR                                                                               PHE                                                                               GLY                                                                               LYS                                                                               ASP                                                                               SER                                                                               PHE                                                                               ASN                                                                               TYR                                                                               TRP                                                                               SER                                                                               GLY                               SEQRES                                                                               24 ASN                                                                               TYR                                                                               VAL                                                                               GLU                                                                               THR                                                                               ARG                                                                               PRO                                                                               SER                                                                               ILE                                                                               GLY                                                                               SER                                                                               SER                                                                               LYS                               SEQRES                                                                               25 THR                                                                               ILE                                                                               THR                                                                               SER                                                                               PRO                                                                               PHE                                                                               TYR                                                                               GLY                                                                               ASP                                                                               LYS                                                                               SER                                                                               THR                                                                               GLU                               SEQRES                                                                               26 PRO                                                                               VAL                                                                               GLN                                                                               LYS                                                                               LEU                                                                               SER                                                                               PHE                                                                               ASP                                                                               GLY                                                                               GLN                                                                               LYS                                                                               VAL                                                                               TYR                               SEQRES                                                                               27 ARG                                                                               THR                                                                               ILE                                                                               ALA                                                                               ASN                                                                               THR                                                                               ASP                                                                               VAL                                                                               ALA                                                                               ALA                                                                               TRP                                                                               PRO                                                                               ASN                               SEQRES                                                                               28 GLY                                                                               LYS                                                                               VAL                                                                               TYR                                                                               LEU                                                                               GLY                                                                               VAL                                                                               THR                                                                               LYS                                                                               VAL                                                                               ASP                                                                               PHE                                                                               SER                               SEQRES                                                                               29 GLN                                                                               TYR                                                                               ASP                                                                               ASP                                                                               GLN                                                                               LYS                                                                               ASN                                                                               GLU                                                                               THR                                                                               SER                                                                               THR                                                                               GLN                                                                               THR                               SEQRES                                                                               30 TYR                                                                               ASP                                                                               SER                                                                               LYS                                                                               ARG                                                                               ASN                                                                               ASN                                                                               GLY                                                                               HIS                                                                               VAL                                                                               SER                                                                               ALA                                                                               GLN                               SEQRES                                                                               31 ASP                                                                               SER                                                                               ILE                                                                               ASP                                                                               GLN                                                                               LEU                                                                               PRO                                                                               PRO                                                                               GLU                                                                               THR                                                                               THR                                                                               ASP                                                                               GLU                               SEQRES                                                                               32 PRO                                                                               LEU                                                                               GLU                                                                               LYS                                                                               ALA                                                                               TYR                                                                               SER                                                                               HIS                                                                               GLN                                                                               LEU                                                                               ASN                                                                               TYR                                                                               ALA                               SEQRES                                                                               33 GLU                                                                               CYS                                                                               PHE                                                                               LEU                                                                               MET                                                                               GLN                                                                               ASP                                                                               ARG                                                                               ARG                                                                               GLY                                                                               THR                                                                               ILE                                                                               PRO                               SEQRES                                                                               34 PHE                                                                               PHE                                                                               THR                                                                               TRP                                                                               THR                                                                               HIS                                                                               ARG                                                                               SER                                                                               VAL                                                                               ASP                                                                               PHE                                                                               PHE                                                                               ASN                               SEQRES                                                                               35 THR                                                                               ILE                                                                               ASP                                                                               ALA                                                                               GLU                                                                               LYS                                                                               ILE                                                                               THR                                                                               GLN                                                                               LEU                                                                               PRO                                                                               VAL                                                                               VAL                               SEQRES                                                                               36 LYS                                                                               ALA                                                                               TYR                                                                               ALA                                                                               LEU                                                                               SER                                                                               SER                                                                               GLY                                                                               ALA                                                                               SER                                                                               ILE                                                                               ILE                                                                               GLU                               SEQRES                                                                               37 GLY                                                                               PRO                                                                               GLY                                                                               PHE                                                                               THR                                                                               GLY                                                                               GLY                                                                               ASN                                                                               LEU                                                                               LEU                                                                               PHE                                                                               LEU                                                                               LYS                               SEQRES                                                                               38 GLU                                                                               SER                                                                               SER                                                                               ASN                                                                               SER                                                                               ILE                                                                               ALA                                                                               LYS                                                                               PHE                                                                               LYS                                                                               VAL                                                                               THR                                                                               LEU                               SEQRES                                                                               39 ASN                                                                               SER                                                                               ALA                                                                               ALA                                                                               LEU                                                                               LEU                                                                               GLN                                                                               ARG                                                                               TYR                                                                               ARG                                                                               VAL                                                                               ARG                                                                               ILE                               SEQRES                                                                               40 ARG                                                                               TYR                                                                               ALA                                                                               SER                                                                               THR                                                                               THR                                                                               ASN                                                                               LEU                                                                               ARG                                                                               LEU                                                                               PHE                                                                               VAL                                                                               GLN                               SEQRES                                                                               41 ASN                                                                               SER                                                                               ASN                                                                               ASN                                                                               ASP                                                                               PHE                                                                               LEU                                                                               VAL                                                                               ILE                                                                               TYR                                                                               ILE                                                                               ASN                                                                               LYS                               SEQRES                                                                               42 THR                                                                               MET                                                                               ASN                                                                               LYS                                                                               ASP                                                                               ASP                                                                               ASP                                                                               LEU                                                                               THR                                                                               TYR                                                                               GLN                                                                               THR                                                                               PHE                               SEQRES                                                                               43 ASP                                                                               LEU                                                                               ALA                                                                               THR                                                                               THR                                                                               ASN                                                                               SER                                                                               ASN                                                                               MET                                                                               GLY                                                                               PHE                                                                               SER                                                                               GLY                               SEQRES                                                                               44 ASP                                                                               LYS                                                                               ASN                                                                               GLU                                                                               LEU                                                                               ILE                                                                               ILE                                                                               GLY                                                                               ALA                                                                               GLU                                                                               SER                                                                               PHE                                                                               VAL                               SEQRES                                                                               45 SER                                                                               ASN                                                                               GLU                                                                               LYS                                                                               ILE                                                                               TYR                                                                               ILE                                                                               ASP                                                                               LYS                                                                               ILE                                                                               GLU                                                                               PHE                                                                               ILE                               SEQRES                                                                               46 PRO                                                                               VAL                                                                               GLN                                                                               LEU                                                          CRYST1                                                                               122.440                                                                            131.810                                                                            105.370                                                                            90.00                                                                             90.00                                                                             90.00                                                                             C 2 2 21                                                                            8                                              ORIGX1                                                                               1.000000                                                                            0.000000                                                                            0.000000                                                                            0.00000                                                   ORIGX2                                                                               0.000000                                                                            1.000000                                                                            0.000000                                                                            0.00000                                                   ORIGX3                                                                               0.000000                                                                            0.000000                                                                            1.000000                                                                            0.00000                                                   SCALE1                                                                               0.00817                                                                             0.00000                                                                             0.000000                                                                            0.00000                                                   SCALE2                                                                               0.00000                                                                             0.00759                                                                             0.00000                                                                             0.00000                                                   SCALE3                                                                               0.00000                                                                             0.00000                                                                             0.00949                                                                             0.00000                                                   ATOM  1  CB  ASP                                                                               64 38.002                                                                             27.615                                                                             24.114                                                                             1.00                                                                              41.41                                        ATOM  2  CG  ASP                                                                               64 36.543                                                                             27.914                                                                             23.755                                                                             1.00                                                                              52.75                                        ATOM  3  OD1 ASP                                                                               64 35.629                                                                             27.527                                                                             24.530                                                                             1.00                                                                              57.53                                        ATOM  4  OD2 ASP                                                                               64 36.313                                                                             28.570                                                                             22.707                                                                             1.00                                                                              55.49                                        ATOM  5  C   ASP                                                                               64 38.189                                                                             25.132                                                                             23.609                                                                             1.00                                                                              31.24                                        ATOM  6  O   ASP                                                                               64 39.200                                                                             24.940                                                                             22.931                                                                             1.00                                                                              32.62                                        ATOM  7  N   ASP                                                                               64 39.547                                                                             26.161                                                                             25.357                                                                             1.00                                                                              28.94                                        ATOM  8  CA  ASP                                                                               64 38.204                                                                             26.213                                                                             24.712                                                                             1.00                                                                              33.24                                        ATOM  9  N   ALA                                                                               65 37.061                                                                             24.450                                                                             23.398                                                                             1.00                                                                              26.88                                        ATOM  10 CA  ALA                                                                               65 37.015                                                                             23.396                                                                             22.384                                                                             1.00                                                                              24.54                                        ATOM  11 CB  ALA                                                                               65 35.695                                                                             22.650                                                                             22.456                                                                             1.00                                                                              25.47                                        ATOM  12 C   ALA                                                                               65 37.289                                                                             23.923                                                                             20.965                                                                             1.00                                                                              24.59                                        ATOM  13 O   ALA                                                                               65 38.208                                                                             23.470                                                                             20.298                                                                             1.00                                                                              28.06                                        ATOM  14 N   VAL                                                                               66 36.549                                                                             24.933                                                                             20.533                                                                             1.00                                                                              24.47                                        ATOM  15 CA  VAL                                                                               66 36.756                                                                             25.504                                                                             19.203                                                                             1.00                                                                              23.48                                        ATOM  16 CB  VAL                                                                               66 35.728                                                                             26.617                                                                             18.903                                                                             1.00                                                                              21.61                                        ATOM  17 CG1 VAL                                                                               66 36.030                                                                             27.331                                                                             17.611                                                                             1.00                                                                              22.39                                        ATOM  18 CG2 VAL                                                                               66 34.351                                                                             25.996                                                                             18.820                                                                             1.00                                                                              26.75                                        ATOM  19 C   VAL                                                                               66 38.187                                                                             26.004                                                                             19.045                                                                             1.00                                                                              19.98                                        ATOM  20 O   VAL                                                                               66 38.833                                                                             25.670                                                                             18.077                                                                             1.00                                                                              23.77                                        ATOM  21 N   GLY                                                                               67 38.713                                                                             26.713                                                                             20.034                                                                             1.00                                                                              21.48                                        ATOM  22 CA  GLY                                                                               67 40.081                                                                             27.219                                                                             19.954                                                                             1.00                                                                              20.29                                        ATOM  23 C   GLY                                                                               67 41.138                                                                             26.133                                                                             19.879                                                                             1.00                                                                              24.27                                        ATOM  24 O   GLY                                                                               67 42.192                                                                             26.309                                                                             19.265                                                                             1.00                                                                              23.94                                        ATOM  25 N   THR                                                                               68 40.866                                                                             25.002                                                                             20.515                                                                             1.00                                                                              24.20                                        ATOM  26 CA  THR                                                                               68 41.799                                                                             23.896                                                                             20.492                                                                             1.00                                                                              24.14                                        ATOM  27 CB  THR                                                                               68 41.461                                                                             22.851                                                                             21.597                                                                             1.00                                                                              23.58                                        ATOM  28 OG1 THR                                                                               68 41.688                                                                             23.440                                                                             22.875                                                                             1.00                                                                              31.21                                        ATOM  29 CG2 THR                                                                               68 42.340                                                                             21.613                                                                             21.500                                                                             1.00                                                                              27.97                                        ATOM  30 C   THR                                                                               68 41.694                                                                             23.304                                                                             19.103                                                                             1.00                                                                              20.97                                        ATOM  31 O   THR                                                                               68 42.705                                                                             23.072                                                                             18.454                                                                             1.00                                                                              21.45                                        ATOM  32 N   GLY                                                                               69 40.461                                                                             23.174                                                                             18.618                                                                             1.00                                                                              19.58                                        ATOM  33 CA  GLY                                                                               69 40.215                                                                             22.622                                                                             17.293                                                                             1.00                                                                              19.83                                        ATOM  34 C   GLY                                                                               69 40.958                                                                             23.401                                                                             16.229                                                                             1.00                                                                              21.30                                        ATOM  35 O   GLY                                                                               69 41.668                                                                             22.836                                                                             15.387                                                                             1.00                                                                              27.17                                        ATOM  36 N   ILE                                                                               70 40.803                                                                             24.714                                                                             16.292                                                                             1.00                                                                              17.89                                        ATOM  37 CA  ILE                                                                               70 41.439                                                                             25.637                                                                             15.380                                                                             1.00                                                                              14.96                                        ATOM  38 CB  ILE                                                                               70 40.985                                                                             27.081                                                                             15.669                                                                             1.00                                                                              10.04                                        ATOM  39 CG2 ILE                                                                               70 41.955                                                                             28.068                                                                             15.070                                                                             1.00                                                                              12.80                                        ATOM  40 CG1 ILE                                                                               70 39.577                                                                             27.287                                                                             15.087                                                                             1.00                                                                              17.46                                        ATOM  41 CD1 ILE                                                                               70 38.902                                                                             28.609                                                                             15.424                                                                             1.00                                                                              11.32                                        ATOM  42 C   ILE                                                                               70 42.941                                                                             25.539                                                                             15.476                                                                             1.00                                                                              15.70                                        ATOM  43 O   ILE                                                                               70 43.620                                                                             25.618                                                                             14.480                                                                             1.00                                                                              14.84                                        ATOM  44 N   SER                                                                               71 43.456                                                                             25.322                                                                             16.675                                                                             1.00                                                                              20.78                                        ATOM  45 CA  SER                                                                               71 44.886                                                                             25.235                                                                             16.865                                                                             1.00                                                                              21.23                                        ATOM  46 CB  SER                                                                               71 45.203                                                                             25.328                                                                             18.342                                                                             1.00                                                                              27.06                                        ATOM  47 OG  SER                                                                               71 46.602                                                                             25.359                                                                             18.562                                                                             1.00                                                                              38.25                                        ATOM  48 C   SER                                                                               71 45.472                                                                             23.958                                                                             16.271                                                                             1.00                                                                              21.51                                        ATOM  49 O   SER                                                                               71 46.528                                                                             23.993                                                                             15.34                                                                              1.00                                                                              25.89                                        ATOM  50 N   VAL                                                                               72 44.800                                                                             22.835                                                                             16.494                                                                             1.00                                                                              22.02                                        ATOM  51 CA  VAL                                                                               72 45.234                                                                             21.543                                                                             15.966                                                                             1.00                                                                              21.27                                        ATOM  52 CB  VAL                                                                               72 44.307                                                                             20.400                                                                             16.439                                                                             1.00                                                                              18.56                                        ATOM  53 CG1 VAL                                                                               72 44.732                                                                             19.096                                                                             15.847                                                                             1.00                                                                              23.45                                        ATOM  54 CG2 VAL                                                                               72 44.350                                                                             20.282                                                                             17.908                                                                             1.00                                                                              24.48                                        ATOM  55 C   VAL                                                                               72 45.230                                                                             21.580                                                                             14.431                                                                             1.00                                                                              22.84                                        ATOM  56 O   VAL                                                                               72 46.224                                                                             21.210                                                                             13.806                                                                             1.00                                                                              26.65                                        ATOM  57 N   VAL                                                                               73 44.127                                                                             22.028                                                                             13.822                                                                             1.00                                                                              19.72                                        ATOM  58 CA  VAL                                                                               73 44.050                                                                             22.105                                                                             12.359                                                                             1.00                                                                              20.44                                        ATOM  59 CB  VAL                                                                               73 42.619                                                                             22.492                                                                             11.872                                                                             1.00                                                                              20.13                                        ATOM  60 CG1 VAL                                                                               73 42.619                                                                             22.896                                                                             10.378                                                                             1.00                                                                              13.81                                        ATOM  61 CG2 VAL                                                                               73 41.680                                                                             21.308                                                                             12.095                                                                             1.00                                                                              18.37                                        ATOM  62 C   VAL                                                                               73 45.152                                                                             22.995                                                                             11.752                                                                             1.00                                                                              20.22                                        ATOM  63 O   VAL                                                                               73 45.557                                                                             22.797                                                                             10.615                                                                             1.00                                                                              24.33                                        ATOM  64 N   GLY                                                                               74 45.663                                                                             23.939                                                                             12.532                                                                             1.00                                                                              21.00                                        ATOM  65 CA  GLY                                                                               74 46.743                                                                             24.784                                                                             12.072                                                                             1.00                                                                              16.98                                        ATOM  66 C   GLY                                                                               74 48.049                                                                             24.028                                                                             12.226                                                                             1.00                                                                              20.80                                        ATOM  67 O   GLY                                                                               74 48.950                                                                             24.221                                                                             11.434                                                                             1.00                                                                              23.14                                        ATOM  68 N   GLN                                                                               75 48.183                                                                             23.179                                                                             13.247                                                                             1.00                                                                              22.46                                        ATOM  69 CA  GLN                                                                               75 49.438                                                                             22.410                                                                             13.434                                                                             1.00                                                                              25.26                                        ATOM  70 CB  GLN                                                                               75 49.561                                                                             21.810                                                                             14.856                                                                             1.00                                                                              27.10                                        ATOM  71 CG  GLN                                                                               75 49.713                                                                             22.859                                                                             15.996                                                                             1.00                                                                              29.45                                        ATOM  72 CD  GLN                                                                               75 50.044                                                                             22.259                                                                             17.361                                                                             1.00                                                                              31.13                                        ATOM  73 OE1 GLN                                                                               75 51.122                                                                             21.706                                                                             17.557                                                                             1.00                                                                              40.11                                        ATOM  74 NE2 GLN                                                                               75 49.140                                                                             22.408                                                                             18.320                                                                             1.00                                                                              30.96                                        ATOM  75 C   GLN                                                                               75 49.566                                                                             21.308                                                                             12.389                                                                             1.00                                                                              24.92                                        ATOM  76 O   GLN                                                                               75 50.629                                                                             21.109                                                                             11.793                                                                             1.00                                                                              26.68                                        ATOM  77 N   ILE                                                                               76 48.466                                                                             20.601                                                                             12.159                                                                             1.00                                                                              23.54                                        ATOM  78 CA  ILE                                                                               76 48.432                                                                             19.541                                                                             11.174                                                                             1.00                                                                              23.61                                        ATOM  79 CB  ILE                                                                               76 47.092                                                                             18.760                                                                             11.249                                                                             1.00                                                                              22.99                                        ATOM  80 CG2 ILE                                                                               76 47.186                                                                             17.503                                                                             10.408                                                                             1.00                                                                              26.43                                        ATOM  81 CG1 ILE                                                                               76 46.744                                                                             18.375                                                                             12.700                                                                             1.00                                                                              19.22                                        ATOM  82 CD1 ILE                                                                               76 47.392                                                                             17.129                                                                             13.202                                                                             1.00                                                                              12.10                                        ATOM  83 C   ILE                                                                               76 48.659                                                                             20.118                                                                             9.733                                                                              1.00                                                                              24.28                                        ATOM  84 O   ILE                                                                               76 49.445                                                                             19.557                                                                             8.968                                                                              1.00                                                                              25.09                                        ATOM  85 N   LEU                                                                               77 48.004                                                                             21.224                                                                             9.363                                                                              1.00                                                                              18.82                                        ATOM  86 CA  LEU                                                                               77 48.195                                                                             21.810                                                                             8.021                                                                              1.00                                                                              19.38                                        ATOM  87 CB  LEU                                                                               77 47.438                                                                             23.142                                                                             7.864                                                                              1.00                                                                              19.61                                        ATOM  88 CG  LEU                                                                               77 46.056                                                                             23.261                                                                             7.195                                                                              1.00                                                                              17.45                                        ATOM  89 CD1 LEU                                                                               77 45.474                                                                             24.653                                                                             7.434                                                                              1.00                                                                              13.22                                        ATOM  90 CD2 LEU                                                                               77 46.148                                                                             22.973                                                                             5.711                                                                              1.00                                                                              11.85                                        ATOM  91 C   LEU                                                                               77 49.680                                                                             22.050                                                                             7.762                                                                              1.00                                                                              23.62                                        ATOM  92 O   LEU                                                                               77 50.181                                                                             21.881                                                                             6.642                                                                              1.00                                                                              28.58                                        ATOM  93 N   GLY                                                                               78 50.378                                                                             22.474                                                                             8.802                                                                              1.00                                                                              21.75                                        ATOM  94 CA  GLY                                                                               78 51.792                                                                             22.711                                                                             8.676                                                                              1.00                                                                              21.63                                        ATOM  95 C   GLY                                                                               78 52.564                                                                             21.405                                                                             8.563                                                                              1.00                                                                              25.33                                        ATOM  96 O   GLY                                                                               78 53.384                                                                             21.263                                                                             7.665                                                                              1.00                                                                              28.22                                        ATOM  97 N   VAL                                                                               79 52.287                                                                             20.443                                                                             9.449                                                                              1.00                                                                              24.06                                        ATOM  98 CA  VAL                                                                               79 52.998                                                                             19.164                                                                             9.452                                                                              1.00                                                                              18.58                                        ATOM  99 CB  VAL                                                                               79 52.551                                                                             18.244                                                                             10.651                                                                             1.00                                                                              16.10                                        ATOM  100                                                                               CG1 VAL                                                                               79 51.241                                                                             17.506                                                                             10.369                                                                             1.00                                                                              10.60                                        ATOM  101                                                                               CG2 VAL                                                                               79 53.637                                                                             17.275                                                                             10.986                                                                             1.00                                                                              9.60                                         ATOM  102                                                                               C   VAL                                                                               79 52.856                                                                             18.464                                                                             8.100                                                                              1.00                                                                              22.38                                        ATOM  103                                                                               O   VAL                                                                               79 53.835                                                                             17.989                                                                             7.512                                                                              1.00                                                                              24.19                                        ATOM  104                                                                               N   VAL                                                                               80 51.649                                                                             18.516                                                                             7.563                                                                              1.00                                                                              19.05                                        ATOM  105                                                                               CA  VAL                                                                               80 51.330                                                                             17.917                                                                             6.289                                                                              1.00                                                                              19.02                                        ATOM  106                                                                               CB  VAL                                                                               80 49.817                                                                             18.051                                                                             6.073                                                                              1.00                                                                              16.18                                        ATOM  107                                                                               CG1 VAL                                                                               80 49.453                                                                             18.035                                                                             4.624                                                                              1.00                                                                              25.56                                        ATOM  108                                                                               CB2 VAL                                                                               80 49.123                                                                             16.931                                                                             6.820                                                                              1.00                                                                              14.84                                        ATOM  109                                                                               C   VAL                                                                               80 52.172                                                                             18.488                                                                             5.140                                                                              1.00                                                                              16.87                                        ATOM  110                                                                               O   VAL                                                                               80 52.399                                                                             17.827                                                                             4.140                                                                              1.00                                                                              20.45                                        ATOM  111                                                                               N   GLY                                                                               81 52.668                                                                             19.704                                                                             5.319                                                                              1.00                                                                              16.74                                        ATOM  112                                                                               CA  GLY                                                                               81 53.499                                                                             20.337                                                                             4.318                                                                              1.00                                                                              11.13                                        ATOM  113                                                                               C   GLY                                                                               81 54.941                                                                             19.919                                                                             4.468                                                                              1.00                                                                              13.55                                        ATOM  114                                                                               O   GLY                                                                               81 55.812                                                                             20.383                                                                             3.738                                                                              1.00                                                                              16.53                                        ATOM  115                                                                               N   VAL                                                                               82 55.200                                                                             19.022                                                                             5.409                                                                              1.00                                                                              15.12                                        ATOM  116                                                                               CA  VAL                                                                               82 56.556                                                                             18.526                                                                             5.665                                                                              1.00                                                                              16.31                                        ATOM  117                                                                               CB  VAL                                                                               82 56.861                                                                             18.482                                                                             7.176                                                                              1.00                                                                              14.93                                        ATOM  118                                                                               CG1 VAL                                                                               82 58.245                                                                             17.911                                                                             7.438                                                                              1.00                                                                              14.94                                        ATOM  119                                                                               CG2 VAL                                                                               82 56.758                                                                             19.879                                                                             7.759                                                                              1.00                                                                              15.19                                        ATOM  120                                                                               C   VAL                                                                               82 56.632                                                                             17.125                                                                             5.094                                                                              1.00                                                                              14.65                                        ATOM  121                                                                               O   VAL                                                                               82 55.702                                                                             16.348                                                                             5.232                                                                              1.00                                                                              15.48                                        ATOM  122                                                                               N   PRO                                                                               83 57.754                                                                             16.762                                                                             4.481                                                                              1.00                                                                              19.00                                        ATOM  123                                                                               CD  PRO                                                                               83 58.996                                                                             17.501                                                                             4.237                                                                              1.00                                                                              18.29                                        ATOM  124                                                                               CA  PRO                                                                               83 57.845                                                                             15.418                                                                             3.917                                                                              1.00                                                                              22.61                                        ATOM  125                                                                               CB  PRO                                                                               83 59.296                                                                             15.336                                                                             3.482                                                                              1.00                                                                              18.37                                        ATOM  126                                                                               CG  PRO                                                                               83 59.574                                                                             16.726                                                                             3.089                                                                              1.00                                                                              21.28                                        ATOM  127                                                                               C   PRO                                                                               83 57.526                                                                             14.372                                                                             4.953                                                                              1.00                                                                              24.83                                        ATOM  128                                                                               O   PRO                                                                               83 57.892                                                                             14.532                                                                             6.124                                                                              1.00                                                                              29.53                                        ATOM  129                                                                               N   PHE                                                                               84 56.815                                                                             13.335                                                                             4.521                                                                              1.00                                                                              24.14                                        ATOM  130                                                                               CA  PHE                                                                               84 56.430                                                                             12.238                                                                             5.382                                                                              1.00                                                                              25.82                                        ATOM  131                                                                               CB  PHE                                                                               84 57.675                                                                             11.577                                                                             5.954                                                                              1.00                                                                              28.96                                        ATOM  132                                                                               CG  PHE                                                                               84 58.498                                                                             10.908                                                                             4.926                                                                              1.00                                                                              34.74                                        ATOM  133                                                                               CD1 PHE                                                                               84 59.878                                                                             11.046                                                                             4.924                                                                              1.00                                                                              39.61                                        ATOM  134                                                                               CD2 PHE                                                                               84 57.890                                                                             10.147                                                                             3.937                                                                              1.00                                                                              35.01                                        ATOM  135                                                                               CE1 PHE                                                                               84 60.645                                                                             10.431                                                                             3.946                                                                              1.00                                                                              40.72                                        ATOM  136                                                                               CE2 PHE                                                                               84 58.638                                                                             9.534                                                                              2.967                                                                              1.00                                                                              38.56                                        ATOM  137                                                                               CZ  PHE                                                                               84 60.023                                                                             9.673                                                                              2.964                                                                              1.00                                                                              40.66                                        ATOM  138                                                                               C   PHE                                                                               84 55.520                                                                             12.692                                                                             6.493                                                                              1.00                                                                              27.58                                        ATOM  139                                                                               O   PHE                                                                               84 55.566                                                                             12.154                                                                             7.595                                                                              1.00                                                                              27.77                                        ATOM  140                                                                               N   ALA                                                                               85 54.689                                                                             13.690                                                                             6.204                                                                              1.00                                                                              29.68                                        ATOM  141                                                                               CA  ALA                                                                               85 53.764                                                                             14.220                                                                             7.193                                                                              1.00                                                                              24.88                                        ATOM  142                                                                               CB  ALA                                                                               85 52.627                                                                             13.226                                                                             7.437                                                                              1.00                                                                              21.36                                        ATOM  143                                                                               C   ALA                                                                               85 54.515                                                                             14.562                                                                             8.496                                                                              1.00                                                                              24.27                                        ATOM  144                                                                               O   ALA                                                                               85 54.003                                                                             14.356                                                                             9.596                                                                              1.00                                                                              23.70                                        ATOM  145                                                                               N   GLY                                                                               86 55.737                                                                             15.081                                                                             8.338                                                                              1.00                                                                              22.37                                        ATOM  146                                                                               CA  GLY                                                                               86 56.560                                                                             15.491                                                                             9.465                                                                              1.00                                                                              20.63                                        ATOM  147                                                                               C   GLY                                                                               86 57.025                                                                             14.410                                                                             10.409                                                                             1.00                                                                              22.40                                        ATOM  148                                                                               O   GLY                                                                               86 57.475                                                                             14.705                                                                             11.509                                                                             1.00                                                                              23.81                                        ATOM  149                                                                               N   ALA                                                                               87 56.976                                                                             13.161                                                                             9.965                                                                              1.00                                                                              24.78                                        ATOM  150                                                                               CA  ALA                                                                               87 57.383                                                                             12.303                                                                             10.789                                                                             1.00                                                                              23.69                                        ATOM  151                                                                               CB  ALA                                                                               87 57.223                                                                             10.728                                                                             10.041                                                                             1.00                                                                              23.32                                        ATOM  152                                                                               C   ALA                                                                               87 58.789                                                                             12.145                                                                             11.295                                                                             1.00                                                                              25.85                                        ATOM  153                                                                               O   ALA                                                                               87 59.114                                                                             11.536                                                                             12.300                                                                             1.00                                                                              28.57                                        ATOM  154                                                                               N   LEU                                                                               88 59.625                                                                             12.932                                                                             10.629                                                                             1.00                                                                              24.24                                        ATOM  155                                                                               CA  LEU                                                                               88 60.995                                                                             13.056                                                                             11.087                                                                             1.00                                                                              27.43                                        ATOM  156                                                                               CB  LEU                                                                               88 61.980                                                                             12.910                                                                             9.934                                                                              1.00                                                                              25.11                                        ATOM  157                                                                               CG  LEU                                                                               88 61.986                                                                             11.535                                                                             9.297                                                                              1.00                                                                              24.44                                        ATOM  158                                                                               CD1 LEU                                                                               88 63.143                                                                             11.477                                                                             8.368                                                                              1.00                                                                              30.54                                        ATOM  159                                                                               CD2 LEU                                                                               88 62.115                                                                             10.462                                                                             10.333                                                                             1.00                                                                              24.31                                        ATOM  160                                                                               C   LEU                                                                               88 61.326                                                                             14.315                                                                             11.872                                                                             1.00                                                                              32.71                                        ATOM  161                                                                               O   LEU                                                                               88 62.508                                                                             14.586                                                                             12.138                                                                             1.00                                                                              36.61                                        ATOM  162                                                                               N   THR                                                                               89 60.305                                                                             15.074                                                                             12.263                                                                             1.00                                                                              34.99                                        ATOM  163                                                                               CA  THR                                                                               89 60.530                                                                             16.303                                                                             13.017                                                                             1.00                                                                              31.40                                        ATOM  164                                                                               CB  THR                                                                               89 59.828                                                                             17.505                                                                             12.335                                                                             1.00                                                                              31.27                                        ATOM  165                                                                               OG1 THR                                                                               89 58.410                                                                             17.351                                                                             12.419                                                                             1.00                                                                              36.54                                        ATOM  166                                                                               CG2 THR                                                                               89 60.200                                                                             17.572                                                                             10.860                                                                             1.00                                                                              26.51                                        ATOM  167                                                                               C   THR                                                                               89 60.067                                                                             16.114                                                                             14.467                                                                             1.00                                                                              30.59                                        ATOM  168                                                                               O   THR                                                                               89 59.862                                                                             14.984                                                                             17.913                                                                             1.00                                                                              29.02                                        ATOM  169                                                                               N   SER                                                                               90 59.899                                                                             17.206                                                                             15.206                                                                             1.00                                                                              30.64                                        ATOM  170                                                                               CA  SER                                                                               90 59.474                                                                             17.091                                                                             16.605                                                                             1.00                                                                              32.41                                        ATOM  171                                                                               CB  SER                                                                               90 60.435                                                                             17.853                                                                             17.517                                                                             1.00                                                                              34.87                                        ATOM  172                                                                               OG  SER                                                                               90 60.308                                                                             19.248                                                                             17.313                                                                             1.00                                                                              42.94                                        ATOM  173                                                                               C   SER                                                                               90 58.024                                                                             17.513                                                                             16.871                                                                             1.00                                                                              28.38                                        ATOM  174                                                                               O   SER                                                                               90 57.630                                                                             17.790                                                                             18.010                                                                             1.00                                                                              25.58                                        ATOM  175                                                                               N   PHE                                                                               91 57.235                                                                             17.519                                                                             15.806                                                                             1.00                                                                              25.68                                        ATOM  176                                                                               CA  PHE                                                                               91 55.827                                                                             17.856                                                                             15.817                                                                             1.00                                                                              27.47                                        ATOM  177                                                                               CB  PHE                                                                               91 55.147                                                                             17.476                                                                             14.535                                                                             1.00                                                                              26.68                                        ATOM  178                                                                               CG  PHE                                                                               91 53.635                                                                             17.344                                                                             14.615                                                                             1.00                                                                              20.42                                        ATOM  179                                                                               CD1 PHE                                                                               91 52.825                                                                             18.740                                                                             14.693                                                                             1.00                                                                              21.17                                        ATOM  180                                                                               CD2 PHE                                                                               91 53.035                                                                             16.085                                                                             14.615                                                                             1.00                                                                              21.20                                        ATOM  181                                                                               CE1 PHE                                                                               91 51.454                                                                             18.351                                                                             14.766                                                                             1.00                                                                              24.02                                        ATOM  182                                                                               CE2 PHE                                                                               91 51.665                                                                             15.953                                                                             14.689                                                                             1.00                                                                              21.82                                        ATOM  183                                                                               CZ  PHE                                                                               91 50.867                                                                             17.089                                                                             14.764                                                                             1.00                                                                              23.87                                        ATOM  184                                                                               C   PHE                                                                               91 55.101                                                                             17.187                                                                             17.050                                                                             1.00                                                                              28.20                                        ATOM  185                                                                               O   PHE                                                                               91 54.310                                                                             17.841                                                                             17.735                                                                             1.00                                                                              36.57                                        ATOM  186                                                                               N   TYR                                                                               92 55.375                                                                             15.913                                                                             17.320                                                                             1.00                                                                              27.08                                        ATOM  187                                                                               CA  TYR                                                                               92 54.681                                                                             15.220                                                                             18.406                                                                             1.00                                                                              25.16                                        ATOM  188                                                                               CB  TYR                                                                               92 55.192                                                                             13.800                                                                             18.545                                                                             1.00                                                                              25.42                                        ATOM  189                                                                               CG  TYR                                                                               92 54.629                                                                             12.844                                                                             17.543                                                                             1.00                                                                              21.49                                        ATOM  190                                                                               CD1 TYR                                                                               92 55.357                                                                             11.734                                                                             17.146                                                                             1.00                                                                              24.41                                        ATOM  191                                                                               CE1 TYR                                                                               92 54.850                                                                             10.833                                                                             16.227                                                                             1.00                                                                              23.54                                        ATOM  192                                                                               CD2 TYR                                                                               92 53.370                                                                             13.038                                                                             16.992                                                                             1.00                                                                              24.88                                        ATOM  193                                                                               CE2 TYR                                                                               92 52.851                                                                             12.136                                                                             16.060                                                                             1.00                                                                              22.72                                        ATOM  194                                                                               CZ  TYR                                                                               92 53.598                                                                             11.034                                                                             15.688                                                                             1.00                                                                              22.21                                        ATOM  195                                                                               OH  TYR                                                                               92 53.085                                                                             10.100                                                                             14.810                                                                             1.00                                                                              19.19                                        ATOM  196                                                                               C   TYR                                                                               92 54.686                                                                             15.906                                                                             19.763                                                                             1.00                                                                              25.24                                        ATOM  197                                                                               O   TYR                                                                               92 53.754                                                                             15.738                                                                             20.539                                                                             1.00                                                                              22.91                                        ATOM  198                                                                               N   GLN                                                                               93 55.725                                                                             16.684                                                                             20.039                                                                             1.00                                                                              27.18                                        ATOM  199                                                                               CA  GLN                                                                               93 55.842                                                                             17.399                                                                             21.303                                                                             1.00                                                                              30.97                                        ATOM  200                                                                               CB  GLN                                                                               93 57.202                                                                             18.081                                                                             21.397                                                                             1.00                                                                              39.48                                        ATOM  201                                                                               CG  GLN                                                                               93 58.371                                                                             17.110                                                                             21.318                                                                             1.00                                                                              51.60                                        ATOM  202                                                                               CD  GLN                                                                               93 58.464                                                                             16.206                                                                             22.541                                                                             1.00                                                                              58.73                                        ATOM  203                                                                               OE1 GLN                                                                               93 58.420                                                                             14.987                                                                             22.430                                                                             1.00                                                                              63.86                                        ATOM  204                                                                               NE2 GLN                                                                               93 58.593                                                                             16.814                                                                             23.716                                                                             1.00                                                                              61.76                                        ATOM  205                                                                               C   GLN                                                                               93 54.744                                                                             18.441                                                                             21.430                                                                             1.00                                                                              31.82                                        ATOM  206                                                                               O   GLN                                                                               93 54.101                                                                             18.539                                                                             22.481                                                                             1.00                                                                              31.42                                        ATOM  207                                                                               N   SER                                                                               94 54.535                                                                             19.215                                                                             20.361                                                                             1.00                                                                              31.11                                        ATOM  208                                                                               CA  SER                                                                               94 53.498                                                                             20.244                                                                             20.341                                                                             1.00                                                                              29.17                                        ATOM  209                                                                               CB  SER                                                                               94 53.567                                                                             21.108                                                                             19.082                                                                             1.00                                                                              27.65                                        ATOM  210                                                                               OG  SER                                                                               94 54.701                                                                             21.944                                                                             19.083                                                                             1.00                                                                              36.29                                        ATOM  211                                                                               C   SER                                                                               94 52.153                                                                             19.563                                                                             20.388                                                                             1.00                                                                              30.39                                        ATOM  212                                                                               O   SER                                                                               94 51.294                                                                             19.937                                                                             21.194                                                                             1.00                                                                              32.51                                        ATOM  213                                                                               N   PHE                                                                               95 51.985                                                                             18.549                                                                             19.537                                                                             1.00                                                                              28.11                                        ATOM  214                                                                               CA  PHE                                                                               95 50.739                                                                             17.791                                                                             19.483                                                                             1.00                                                                              28.46                                        ATOM  215                                                                               CB  PHE                                                                               95 50.832                                                                             16.657                                                                             18.454                                                                             1.00                                                                              27.56                                        ATOM  216                                                                               CG  PHE                                                                               95 49.502                                                                             16.068                                                                             18.086                                                                             1.00                                                                              28.26                                        ATOM  217                                                                               CD1 PHE                                                                               95 48.473                                                                             16.883                                                                             17.610                                                                             1.00                                                                              24.62                                        ATOM  218                                                                               CD2 PHE                                                                               95 49.270                                                                             14.703                                                                             18.224                                                                             1.00                                                                              25.73                                        ATOM  219                                                                               CE1 PHE                                                                               95 47.234                                                                             16.340                                                                             17.282                                                                             1.00                                                                              22.34                                        ATOM  220                                                                               CE2 PHE                                                                               95 48.031                                                                             14.153                                                                             17.895                                                                             1.00                                                                              22.66                                        ATOM  221                                                                               CZ  PHE                                                                               95 47.011                                                                             14.971                                                                             17.424                                                                             1.00                                                                              18.98                                        ATOM  222                                                                               C   PHE                                                                               95 50.390                                                                             17.241                                                                             20.875                                                                             1.00                                                                              26.55                                        ATOM  223                                                                               O   PHE                                                                               95 49.230                                                                             17.306                                                                             21.287                                                                             1.00                                                                              29.64                                        ATOM  224                                                                               N   LEU                                                                               96 51.384                                                                             16.752                                                                             21.617                                                                             1.00                                                                              26.06                                        ATOM  225                                                                               CA  LEU                                                                               96 51.133                                                                             16.232                                                                             22.959                                                                             1.00                                                                              25.65                                        ATOM  226                                                                               CB  LEU                                                                               96 52.395                                                                             15.670                                                                             23.587                                                                             1.00                                                                              25.73                                        ATOM  227                                                                               CG  LEU                                                                               96 52.764                                                                             14.221                                                                             23.325                                                                             1.00                                                                              28.75                                        ATOM  228                                                                               CD1 LEU                                                                               96 53.909                                                                             13.824                                                                             24.246                                                                             1.00                                                                              31.30                                        ATOM  229                                                                               CD2 LEU                                                                               96 51.583                                                                             13.334                                                                             23.583                                                                             1.00                                                                              33.49                                        ATOM  230                                                                               C   LEU                                                                               96 50.581                                                                             17.294                                                                             23.895                                                                             1.00                                                                              25.90                                        ATOM  231                                                                               O   LEU                                                                               96 49.544                                                                             17.079                                                                             24.554                                                                             1.00                                                                              24.48                                        ATOM  232                                                                               N   ASN                                                                               97 51.240                                                                             18.444                                                                             23.951                                                                             1.00                                                                              28.33                                        ATOM  233                                                                               CA  ASN                                                                               97 50.785                                                                             19.512                                                                             24.840                                                                             1.00                                                                              32.74                                        ATOM  234                                                                               CB  ASN                                                                               97 51.680                                                                             20.753                                                                             24.740                                                                             1.00                                                                              36.47                                        ATOM  235                                                                               CG  ASN                                                                               97 53.154                                                                             20.434                                                                             24.807                                                                             1.00                                                                              47.89                                        ATOM  236                                                                               OD1 ASN                                                                               97 53.985                                                                             21.175                                                                             24.248                                                                             1.00                                                                              53.39                                        ATOM  237                                                                               ND1 ASN                                                                               97 53.507                                                                             19.351                                                                             25.504                                                                             1.00                                                                              52.31                                        ATOM  238                                                                               C   ASN                                                                               97 49.355                                                                             19.967                                                                             24.535                                                                             1.00                                                                              34.80                                        ATOM  239                                                                               O   ASN                                                                               97 48.555                                                                             20.198                                                                             25.444                                                                             1.00                                                                              38.94                                        ATOM  240                                                                               N   THR                                                                               98 49.048                                                                             20.122                                                                             23.254                                                                             1.00                                                                              31.52                                        ATOM  241                                                                               CA  THR                                                                               98 47.755                                                                             20.608                                                                             22.849                                                                             1.00                                                                              27.60                                        ATOM  242                                                                               CB  THR                                                                               98 47.855                                                                             21.264                                                                             21.458                                                                             1.00                                                                              32.02                                        ATOM  243                                                                               OG1 THR                                                                               98 46.576                                                                             21.759                                                                             21.047                                                                             1.00                                                                              35.15                                        ATOM  244                                                                               OG2 THR                                                                               98 48.389                                                                             20.301                                                                             20.449                                                                             1.00                                                                              31.67                                        ATOM  245                                                                               C   THR                                                                               98 46.597                                                                             19.632                                                                             22.954                                                                             1.00                                                                              26.56                                        ATOM  246                                                                               O   THR                                                                               98 45.568                                                                             19.985                                                                             23.504                                                                             1.00                                                                              26.90                                        ATOM  247                                                                               N   ILE                                                                               99 46.771                                                                             18.398                                                                             22.495                                                                             1.00                                                                              25.90                                        ATOM  248                                                                               CA  ILE                                                                               99 45.694                                                                             17.414                                                                             22.542                                                                             1.00                                                                              22.63                                        ATOM  249                                                                               CB  ILE                                                                               99 45.495                                                                             16.771                                                                             21.138                                                                             1.00                                                                              21.44                                        ATOM  250                                                                               CG2 ILE                                                                               99 44.567                                                                             15.567                                                                             21.204                                                                             1.00                                                                              21.56                                        ATOM  251                                                                               CG1 ILE                                                                               99 44.888                                                                             17.780                                                                             20.176                                                                             1.00                                                                              18.21                                        ATOM  252                                                                               CD1 ILE                                                                               99 43.507                                                                             18.260                                                                             20.597                                                                             1.00                                                                              21.58                                        ATOM  253                                                                               C   ILE                                                                               99 45.823                                                                             16.317                                                                             23.638                                                                             1.00                                                                              26.20                                        ATOM  254                                                                               O   ILE                                                                               99 44.823                                                                             15.947                                                                             24.283                                                                             1.00                                                                              19.95                                        ATOM  255                                                                               N   TRP                                                                               100                                                                               47.036                                                                             15.824                                                                             23.896                                                                             1.00                                                                              25.49                                        ATOM  256                                                                               CA  TRP                                                                               100                                                                               47.195                                                                             14.775                                                                             24.907                                                                             1.00                                                                              29.32                                        ATOM  257                                                                               CB  TRP                                                                               100                                                                               47.826                                                                             13.507                                                                             24.301                                                                             1.00                                                                              21.69                                        ATOM  258                                                                               CG  TRP                                                                               100                                                                               47.076                                                                             12.975                                                                             23.125                                                                             1.00                                                                              19.06                                        ATOM  259                                                                               CD2 TRP                                                                               100                                                                               45.988                                                                             12.031                                                                             23.134                                                                             1.00                                                                              18.83                                        ATOM  260                                                                               CE2 TRP                                                                               100                                                                               45.564                                                                             11.866                                                                             21.798                                                                             1.00                                                                              14.99                                        ATOM  261                                                                               CE3 TRP                                                                               100                                                                               45.325                                                                             11.316                                                                             24.139                                                                             1.00                                                                              18.15                                        ATOM  262                                                                               CD1 TRP                                                                               100                                                                               47.262                                                                             13.324                                                                             21.818                                                                             1.00                                                                              21.00                                        ATOM  263                                                                               NE1 TRP                                                                               100                                                                               46.357                                                                             12.667                                                                             21.018                                                                             1.00                                                                              19.19                                        ATOM  264                                                                               CZ2 TRP                                                                               100                                                                               44.517                                                                             11.022                                                                             21.440                                                                             1.00                                                                              14.21                                        ATOM  265                                                                               CZ3 TRP                                                                               100                                                                               44.278                                                                             10.471                                                                             23.777                                                                             1.00                                                                              18.67                                        ATOM  266                                                                               CH2 TRP                                                                               100                                                                               43.886                                                                             10.334                                                                             22.441                                                                             1.00                                                                              14.87                                        ATOM  267                                                                               C   TRP                                                                               100                                                                               47.945                                                                             15.199                                                                             26.176                                                                             1.00                                                                              31.48                                        ATOM  268                                                                               O   TRP                                                                               100                                                                               48.938                                                                             14.585                                                                             26.560                                                                             1.00                                                                              32.21                                        ATOM  269                                                                               N   PRO                                                                               101                                                                               47.465                                                                             16.250                                                                             26.854                                                                             1.00                                                                              34.11                                        ATOM  270                                                                               CD  PRO                                                                               101                                                                               46.288                                                                             17.090                                                                             26.574                                                                             1.00                                                                              34.77                                        ATOM  271                                                                               CA  PRO                                                                               101                                                                               48.135                                                                             16.694                                                                             28.074                                                                             1.00                                                                              38.53                                        ATOM  272                                                                               CB  PRO                                                                               101                                                                               47.586                                                                             18.105                                                                             28.248                                                                             1.00                                                                              38.92                                        ATOM  273                                                                               CG  PRO                                                                               101                                                                               46.169                                                                             17.937                                                                             27.818                                                                             1.00                                                                              37.10                                        ATOM  274                                                                               C   PRO                                                                               101                                                                               47.713                                                                             15.771                                                                             29.219                                                                             1.00                                                                              39.63                                        ATOM  275                                                                               O   PRO                                                                               101                                                                               46.600                                                                             15.224                                                                             29.192                                                                             1.00                                                                              39.50                                        ATOM  276                                                                               N   SER                                                                               102                                                                               48.567                                                                             15.633                                                                             30.235                                                                             1.00                                                                              41.84                                        ATOM  277                                                                               CA  SER                                                                               102                                                                               48.283                                                                             14.754                                                                             31.372                                                                             1.00                                                                              42.97                                        ATOM  278                                                                               CB  SER                                                                               102                                                                               49.412                                                                             14.819                                                                             32.397                                                                             1.00                                                                              44.81                                        ATOM  279                                                                               OG  SER                                                                               102                                                                               50.492                                                                             13.979                                                                             32.036                                                                             1.00                                                                              48.18                                        ATOM  280                                                                               C   SER                                                                               102                                                                               46.935                                                                             14.949                                                                             32.072                                                                             1.00                                                                              46.58                                        ATOM  281                                                                               O   SER                                                                               102                                                                               46.304                                                                             13.965                                                                             32.470                                                                             1.00                                                                              47.97                                        ATOM  282                                                                               N   ASP                                                                               103                                                                               46.487                                                                             16.199                                                                             32.211                                                                             1.00                                                                              47.92                                        ATOM  283                                                                               CA  ASP                                                                               103                                                                               45.209                                                                             16.500                                                                             32.872                                                                             1.00                                                                              48.48                                        ATOM  284                                                                               CB  ASP                                                                               103                                                                               45.213                                                                             17.935                                                                             33.379                                                                             1.00                                                                              51.18                                        ATOM  285                                                                               CG  ASP                                                                               103                                                                               45.529                                                                             18.936                                                                             32.289                                                                             1.00                                                                              54.93                                        ATOM  286                                                                               OD1 ASP                                                                               103                                                                               44.942                                                                             18.862                                                                             31.177                                                                             1.00                                                                              53.60                                        ATOM  287                                                                               OD2 ASP                                                                               103                                                                               46.375                                                                             19.813                                                                             32.558                                                                             1.00                                                                              61.10                                        ATOM  288                                                                               C   ASP                                                                               103                                                                               43.932                                                                             16.268                                                                             32.049                                                                             1.00                                                                              48.05                                        ATOM  289                                                                               O   ASP                                                                               103                                                                               42.835                                                                             16.518                                                                             32.542                                                                             1.00                                                                              52.24                                        ATOM  290                                                                               N   ALA                                                                               104                                                                               44.085                                                                             15.863                                                                             30.788                                                                             1.00                                                                              45.10                                        ATOM  291                                                                               CA  ALA                                                                               104                                                                               42.941                                                                             15.591                                                                             29.873                                                                             1.00                                                                              39.51                                        ATOM  292                                                                               CB  ALA                                                                               104                                                                               42.393                                                                             14.204                                                                             30.114                                                                             1.00                                                                              40.01                                        ATOM  293                                                                               C   ALA                                                                               104                                                                               41.863                                                                             16.630                                                                             29.850                                                                             1.00                                                                              39.09                                        ATOM  294                                                                               O   ALA                                                                               104                                                                               40.698                                                                             16.314                                                                             29.606                                                                             1.00                                                                              34.52                                        ATOM  295                                                                               N   ASP                                                                               105                                                                               42.235                                                                             17.881                                                                             30.074                                                                             1.00                                                                              38.82                                        ATOM  296                                                                               CA  ASP                                                                               105                                                                               41.266                                                                             18.964                                                                             30.028                                                                             1.00                                                                              39.02                                        ATOM  297                                                                               CB  ASP                                                                               105                                                                               41.930                                                                             20.288                                                                             30.370                                                                             1.00                                                                              43.59                                        ATOM  298                                                                               CG  ASP                                                                               105                                                                               42.173                                                                             20.445                                                                             31.846                                                                             1.00                                                                              52.33                                        ATOM  299                                                                               OD1 ASP                                                                               105                                                                               43.073                                                                             21.242                                                                             32.199                                                                             1.00                                                                              57.65                                        ATOM  300                                                                               OD2 ASP                                                                               105                                                                               41.465                                                                             19.781                                                                             32.650                                                                             1.00                                                                              54.73                                        ATOM  301                                                                               C   ASP                                                                               105                                                                               40.613                                                                             19.072                                                                             28.657                                                                             1.00                                                                              34.78                                        ATOM  302                                                                               O   ASP                                                                               105                                                                               39.385                                                                             19.155                                                                             28.551                                                                             1.00                                                                              35.07                                        ATOM  303                                                                               N   PRO                                                                               106                                                                               41.423                                                                             19.017                                                                             27.582                                                                             1.00                                                                              30.97                                        ATOM  304                                                                               CD  PRO                                                                               106                                                                               42.876                                                                             18.735                                                                             27.539                                                                             1.00                                                                              27.68                                        ATOM  305                                                                               CA  PRO                                                                               106                                                                               40.882                                                                             19.116                                                                             26.226                                                                             1.00                                                                              27.20                                        ATOM  306                                                                               CB  PRO                                                                               106                                                                               42.044                                                                             18.617                                                                             25.371                                                                             1.00                                                                              26.38                                        ATOM  307                                                                               CG  PRO                                                                               106                                                                               43.232                                                                             19.059                                                                             26.125                                                                             1.00                                                                              27.63                                        ATOM  308                                                                               C   PRO                                                                               106                                                                               39.639                                                                             18.259                                                                             25.990                                                                             1.00                                                                              25.44                                        ATOM  309                                                                               O   PRO                                                                               106                                                                               38.660                                                                             18.711                                                                             25.416                                                                             1.00                                                                              32.50                                        ATOM  310                                                                               N   TRP                                                                               107                                                                               39.684                                                                             17.025                                                                             26.457                                                                             1.00                                                                              22.67                                        ATOM  311                                                                               CA  TRP                                                                               107                                                                               38.604                                                                             16.080                                                                             26.270                                                                             1.00                                                                              21.40                                        ATOM  312                                                                               CB  TRP                                                                               107                                                                               39.090                                                                             14.697                                                                             26.695                                                                             1.00                                                                              21.20                                        ATOM  313                                                                               CG  TRP                                                                               107                                                                               40.377                                                                             14.367                                                                             26.011                                                                             1.00                                                                              21.35                                        ATOM  314                                                                               CD2 TRP                                                                               107                                                                               40.549                                                                             14.025                                                                             24.630                                                                             1.00                                                                              23.47                                        ATOM  315                                                                               CE2 TRP                                                                               107                                                                               41.926                                                                             13.818                                                                             24.418                                                                             1.00                                                                              26.19                                        ATOM  316                                                                               CE3 TRP                                                                               107                                                                               39.666                                                                             13.859                                                                             23.552                                                                             1.00                                                                              22.11                                        ATOM  317                                                                               CD1 TRP                                                                               107                                                                               41.617                                                                             14.367                                                                             26.558                                                                             1.00                                                                              22.90                                        ATOM  318                                                                               NE1 TRP                                                                               107                                                                               42.560                                                                             14.040                                                                             25.610                                                                             1.00                                                                              23.51                                        ATOM  319                                                                               CZ2 TRP                                                                               107                                                                               42.442                                                                             13.453                                                                             23.171                                                                             1.00                                                                              27.67                                        ATOM  320                                                                               CZ3 TRP                                                                               107                                                                               40.175                                                                             13.499                                                                             22.326                                                                             1.00                                                                              14.25                                        ATOM  321                                                                               CH2 TRP                                                                               107                                                                               41.551                                                                             13.294                                                                             22.144                                                                             1.00                                                                              23.37                                        ATOM  322                                                                               C   TRP                                                                               107                                                                               37.305                                                                             16.463                                                                             26.944                                                                             1.00                                                                              22.55                                        ATOM  323                                                                               O   TRP                                                                               107                                                                               36.249                                                                             16.431                                                                             26.323                                                                             1.00                                                                              17.29                                        ATOM  324                                                                               N   LYS                                                                               108                                                                               37.375                                                                             16.879                                                                             28.200                                                                             1.00                                                                              28.78                                        ATOM  325                                                                               CA  LYS                                                                               108                                                                               36.156                                                                             17.274                                                                             28.902                                                                             1.00                                                                              31.84                                        ATOM  326                                                                               CB  LYS                                                                               108                                                                               36.463                                                                             17.711                                                                             30.334                                                                             1.00                                                                              33.26                                        ATOM  327                                                                               CG  LYS                                                                               108                                                                               37.016                                                                             16.622                                                                             31.215                                                                             1.00                                                                              38.45                                        ATOM  328                                                                               CD  LYS                                                                               108                                                                               38.128                                                                             17.191                                                                             32.086                                                                             1.00                                                                              48.94                                        ATOM  329                                                                               CE  LYS                                                                               108                                                                               38.924                                                                             16.104                                                                             32.803                                                                             1.00                                                                              54.01                                        ATOM  330                                                                               NZ  LYS                                                                               108                                                                               40.202                                                                             16.621                                                                             33.392                                                                             1.00                                                                              55.46                                        ATOM  331                                                                               C   LYS                                                                               108                                                                               35.513                                                                             18.416                                                                             28.120                                                                             1.00                                                                              30.68                                        ATOM  332                                                                               O   LYS                                                                               108                                                                               34.296                                                                             18.572                                                                             28.130                                                                             1.00                                                                              35.50                                        ATOM  333                                                                               N   ALA                                                                               109                                                                               36.342                                                                             19.190                                                                             27.428                                                                             1.00                                                                              28.04                                        ATOM  334                                                                               CA  ALA                                                                               109                                                                               35.885                                                                             20.306                                                                             26.609                                                                             1.00                                                                              27.59                                        ATOM  335                                                                               CB  ALA                                                                               109                                                                               37.064                                                                             21.153                                                                             26.194                                                                             1.00                                                                              33.31                                        ATOM  336                                                                               C   ALA                                                                               109                                                                               35.144                                                                             19.817                                                                             25.372                                                                             1.00                                                                              26.82                                        ATOM  337                                                                               O   ALA                                                                               109                                                                               34.100                                                                             20.362                                                                             24.999                                                                             1.00                                                                              28.89                                        ATOM  338                                                                               N   PHE                                                                               110                                                                               35.688                                                                             18.796                                                                             24.723                                                                             1.00                                                                              23.59                                        ATOM  339                                                                               CA  PHE                                                                               110                                                                               35.043                                                                             18.245                                                                             23.548                                                                             1.00                                                                              21.61                                        ATOM  340                                                                               CB  PHE                                                                               110                                                                               35.998                                                                             17.325                                                                             22.801                                                                             1.00                                                                              22.67                                        ATOM  341                                                                               CG  PHE                                                                               110                                                                               37.166                                                                             18.041                                                                             22.180                                                                             1.00                                                                              24.76                                        ATOM  342                                                                               CD1 PHE                                                                               110                                                                               38.474                                                                             17.607                                                                             22.421                                                                             1.00                                                                              22.40                                        ATOM  343                                                                               CD2 PHE                                                                               110                                                                               36.960                                                                             19.151                                                                             21.361                                                                             1.00                                                                              19.11                                        ATOM  344                                                                               CE1 PHE                                                                               110                                                                               39.555                                                                             18.274                                                                             21.859                                                                             1.00                                                                              25.16                                        ATOM  345                                                                               CE2 PHE                                                                               110                                                                               38.033                                                                             19.818                                                                             20.796                                                                             1.00                                                                              24.29                                        ATOM  346                                                                               CZ  PHE                                                                               110                                                                               39.334                                                                             19.383                                                                             21.044                                                                             1.00                                                                              24.30                                        ATOM  347                                                                               C   PHE                                                                               110                                                                               33.791                                                                             17.482                                                                             23.965                                                                             1.00                                                                              35.43                                        ATOM  348                                                                               O   PHE                                                                               110                                                                               32.754                                                                             17.566                                                                             23.304                                                                             1.00                                                                              26.45                                        ATOM  349                                                                               N   MET                                                                               111                                                                               33.883                                                                             16.801                                                                             25.109                                                                             1.00                                                                              29.94                                        ATOM  350                                                                               CA  MET                                                                               111                                                                               32.788                                                                             16.020                                                                             25.687                                                                             1.00                                                                              30.42                                        ATOM  351                                                                               CB  MET                                                                               111                                                                               33.255                                                                             15.316                                                                             26.957                                                                             1.00                                                                              28.69                                        ATOM  352                                                                               CG  MET                                                                               111                                                                               34.336                                                                             14.297                                                                             26.747                                                                             1.00                                                                              32.84                                        ATOM  353                                                                               SD  MET                                                                               111                                                                               33.729                                                                             12.637                                                                             26.927                                                                             1.00                                                                              32.93                                        ATOM  354                                                                               CE  MET                                                                               111                                                                               35.263                                                                             11.745                                                                             26.874                                                                             1.00                                                                              35.32                                        ATOM  355                                                                               C   MET                                                                               111                                                                               31.591                                                                             16.886                                                                             26.058                                                                             1.00                                                                              31.28                                        ATOM  356                                                                               O   MET                                                                               111                                                                               30.478                                                                             16.375                                                                             26.195                                                                             1.00                                                                              35.76                                        ATOM  357                                                                               N   ALA                                                                               112                                                                               31.821                                                                             18.180                                                                             26.276                                                                             1.00                                                                              33.59                                        ATOM  358                                                                               CA  ALA                                                                               112                                                                               30.737                                                                             19.103                                                                             26.650                                                                             1.00                                                                              36.25                                        ATOM  359                                                                               CB  ALA                                                                               112                                                                               31.117                                                                             19.895                                                                             27.908                                                                             1.00                                                                              37.41                                        ATOM  360                                                                               C   ALA                                                                               112                                                                               30.348                                                                             20.073                                                                             25.536                                                                             1.00                                                                              35.59                                        ATOM  361                                                                               O   ALA                                                                               112                                                                               29.274                                                                             20.690                                                                             25.578                                                                             1.00                                                                              36.38                                        ATOM  362                                                                               N   GLN                                                                               113                                                                               31.192                                                                             30.153                                                                             24.517                                                                             1.00                                                                              29.50                                        ATOM  363                                                                               CA  GLN                                                                               113                                                                               30.958                                                                             21.070                                                                             23.438                                                                             1.00                                                                              25.32                                        ATOM  364                                                                               CB  GLN                                                                               113                                                                               32.137                                                                             21.034                                                                             22.459                                                                             1.00                                                                              28.47                                        ATOM  365                                                                               CG  GLN                                                                               113                                                                               31.821                                                                             21.592                                                                             21.091                                                                             1.00                                                                              22.47                                        ATOM  366                                                                               CD  GLN                                                                               113                                                                               33.006                                                                             21.581                                                                             20.152                                                                             1.00                                                                              22.91                                        ATOM  367                                                                               OE1 GLN                                                                               113                                                                               33.272                                                                             22.581                                                                             19.471                                                                             1.00                                                                              18.94                                        ATOM  368                                                                               NE2 GLN                                                                               113                                                                               33.722                                                                             20.450                                                                             20.091                                                                             1.00                                                                              16.92                                        ATOM  369                                                                               C   GLN                                                                               113                                                                               29.659                                                                             20.830                                                                             22.714                                                                             1.00                                                                              23.43                                        ATOM  370                                                                               O   GLN                                                                               113                                                                               28.956                                                                             21.770                                                                             22.387                                                                             1.00                                                                              24.46                                        ATOM  371                                                                               N   VAL                                                                               114                                                                               29.306                                                                             19.583                                                                             22.472                                                                             1.00                                                                              23.56                                        ATOM  372                                                                               CA  VAL                                                                               114                                                                               28.091                                                                             19.362                                                                             21.721                                                                             1.00                                                                              22.74                                        ATOM  373                                                                               CB  VAL                                                                               114                                                                               28.206                                                                             18.138                                                                             20.835                                                                             1.00                                                                              24.34                                        ATOM  374                                                                               CG1 VAL                                                                               114                                                                               27.267                                                                             18.280                                                                             19.657                                                                             1.00                                                                              24.59                                        ATOM  375                                                                               CG2 VAL                                                                               114                                                                               29.630                                                                             17.968                                                                             20.349                                                                             1.00                                                                              18.65                                        ATOM  376                                                                               C   VAL                                                                               114                                                                               26.818                                                                             19.322                                                                             22.563                                                                             1.00                                                                              26.29                                        ATOM  377                                                                               O   VAL                                                                               114                                                                               25.756                                                                             19.710                                                                             22.083                                                                             1.00                                                                              27.22                                        ATOM  378                                                                               N   GLU                                                                               115                                                                               26.927                                                                             18.897                                                                             23.820                                                                             1.00                                                                              26.49                                        ATOM  379                                                                               CA  GLU                                                                               115                                                                               25.778                                                                             18.857                                                                             24.719                                                                             1.00                                                                              23.95                                        ATOM  380                                                                               CB  GLU                                                                               115                                                                               26.230                                                                             18.527                                                                             26.148                                                                             1.00                                                                              26.34                                        ATOM  381                                                                               CG  GLU                                                                               115                                                                               26.726                                                                             17.072                                                                             26.345                                                                             1.00                                                                              27.76                                        ATOM  382                                                                               CD  GLU                                                                               115                                                                               27.170                                                                             16.764                                                                             27.780                                                                             1.00                                                                              34.27                                        ATOM  383                                                                               OE1 GLU                                                                               115                                                                               27.688                                                                             17.665                                                                             28.494                                                                             1.00                                                                              34.36                                        ATOM  384                                                                               OE2 GLU                                                                               115                                                                               27.005                                                                             15.604                                                                             28.200                                                                             1.00                                                                              34.20                                        ATOM  385                                                                               C   GLU                                                                               115                                                                               25.170                                                                             20.250                                                                             24.665                                                                             1.00                                                                              24.85                                        ATOM  386                                                                               O   GLU                                                                               115                                                                               23.971                                                                             20.405                                                                             24.453                                                                             1.00                                                                              26.55                                        ATOM  387                                                                               N   VAL                                                                               116                                                                               26.041                                                                             21.254                                                                             24.740                                                                             1.00                                                                              23.84                                        ATOM  388                                                                               CA  VAL                                                                               116                                                                               25.675                                                                             22.675                                                                             24.680                                                                             1.00                                                                              26.40                                        ATOM  389                                                                               CB  VAL                                                                               116                                                                               26.963                                                                             23.573                                                                             24.910                                                                             1.00                                                                              26.32                                        ATOM  390                                                                               CG1 VAL                                                                               116                                                                               26.732                                                                             25.017                                                                             24.498                                                                             1.00                                                                              22.18                                        ATOM  391                                                                               CG2 VAL                                                                               116                                                                               27.417                                                                             23.519                                                                             26.378                                                                             1.00                                                                              22.96                                        ATOM  392                                                                               C   VAL                                                                               116                                                                               24.982                                                                             23.087                                                                             23.354                                                                             1.00                                                                              31.33                                        ATOM  393                                                                               O   VAL                                                                               116                                                                               24.060                                                                             23.912                                                                             23.357                                                                             1.00                                                                              30.41                                        ATOM  394                                                                               N   LEU                                                                               117                                                                               25.428                                                                             22.516                                                                             22.233                                                                             1.00                                                                              34.23                                        ATOM  395                                                                               CA  LEU                                                                               117                                                                               24.884                                                                             22.852                                                                             20.912                                                                             1.00                                                                              33.73                                        ATOM  396                                                                               CB  LEU                                                                               117                                                                               25.917                                                                             22.601                                                                             19.801                                                                             1.00                                                                              28.04                                        ATOM  397                                                                               CG  LEU                                                                               117                                                                               27.208                                                                             23.430                                                                             19.781                                                                             1.00                                                                              29.91                                        ATOM  398                                                                               CD1 LEU                                                                               117                                                                               28.256                                                                             22.795                                                                             18.853                                                                             1.00                                                                              24.06                                        ATOM  399                                                                               CD2 LEU                                                                               117                                                                               26.906                                                                             24.848                                                                             19.368                                                                             1.00                                                                              25.56                                        ATOM  400                                                                               C   LEU                                                                               117                                                                               23.585                                                                             22.144                                                                             20.568                                                                             1.00                                                                              35.30                                        ATOM  401                                                                               O   LEU                                                                               117                                                                               22.852                                                                             22.593                                                                             19.692                                                                             1.00                                                                              41.08                                        ATOM  402                                                                               N   ILE                                                                               118                                                                               23.315                                                                             20.998                                                                             21.171                                                                             1.00                                                                              32.43                                        ATOM  403                                                                               CA  ILE                                                                               118                                                                               22.056                                                                             20.350                                                                             20.861                                                                             1.00                                                                              34.23                                        ATOM  404                                                                               CB  ILE                                                                               118                                                                               22.219                                                                             18.996                                                                             20.103                                                                             1.00                                                                              33.52                                        ATOM  405                                                                               CG2 ILE                                                                               118                                                                               22.754                                                                             19.223                                                                             18.688                                                                             1.00                                                                              34.50                                        ATOM  406                                                                               CG1 ILE                                                                               118                                                                               23.104                                                                             18.030                                                                             20.880                                                                             1.00                                                                              31.03                                        ATOM  407                                                                               CD1 ILE                                                                               118                                                                               23.022                                                                             16.619                                                                             20.353                                                                             1.00                                                                              28.15                                        ATOM  408                                                                               C   ILE                                                                               118                                                                               21.268                                                                             20.161                                                                             22.140                                                                             1.00                                                                              36.68                                        ATOM  409                                                                               O   ILE                                                                               118                                                                               20.284                                                                             19.420                                                                             22.174                                                                             1.00                                                                              40.44                                        ATOM  410                                                                               N   ASP                                                                               119                                                                               21.668                                                                             20.898                                                                             23.173                                                                             1.00                                                                              42.31                                        ATOM  411                                                                               CA  ASP                                                                               119                                                                               21.037                                                                             20.819                                                                             24.487                                                                             1.00                                                                              48.51                                        ATOM  412                                                                               CB  ASP                                                                               119                                                                               19.998                                                                             21.936                                                                             24.690                                                                             1.00                                                                              53.59                                        ATOM  413                                                                               CG  ASP                                                                               119                                                                               20.619                                                                             23.201                                                                             25.331                                                                             1.00                                                                              63.54                                        ATOM  414                                                                               OD1 ASP                                                                               119                                                                               20.738                                                                             23.251                                                                             26.582                                                                             1.00                                                                              67.03                                        ATOM  415                                                                               OD2 ASP                                                                               119                                                                               21.023                                                                             24.133                                                                             24.588                                                                             1.00                                                                              66.97                                        ATOM  416                                                                               C   ASP                                                                               119                                                                               20.515                                                                             19.416                                                                             24.824                                                                             1.00                                                                              47.46                                        ATOM  417                                                                               O   ASP                                                                               119                                                                               19.316                                                                             19.175                                                                             25.000                                                                             1.00                                                                              46.57                                        ATOM  418                                                                               N   LYS                                                                               120                                                                               21.474                                                                             18.499                                                                             24.884                                                                             1.00                                                                              45.37                                        ATOM  419                                                                               CA  LYS                                                                               120                                                                               21.247                                                                             17.099                                                                             25.180                                                                             1.00                                                                              43.83                                        ATOM  420                                                                               CB  LYS                                                                               120                                                                               21.220                                                                             16.296                                                                             23.874                                                                             1.00                                                                              48.35                                        ATOM  421                                                                               CG  LYS                                                                               120                                                                               20.134                                                                             15.228                                                                             23.781                                                                             1.00                                                                              54.30                                        ATOM  422                                                                               CD  LYS                                                                               120                                                                               20.675                                                                             14.015                                                                             23.024                                                                             1.00                                                                              64.38                                        ATOM  423                                                                               CE  LYS                                                                               120                                                                               19.703                                                                             12.838                                                                             22.981                                                                             1.00                                                                              66.37                                        ATOM  424                                                                               NZ  LYS                                                                               120                                                                               20.427                                                                             11.562                                                                             22.663                                                                             1.00                                                                              65.78                                        ATOM  425                                                                               C   LYS                                                                               120                                                                               22.465                                                                             16.724                                                                             26.022                                                                             1.00                                                                              40.72                                        ATOM  426                                                                               O   LYS                                                                               120                                                                               23.413                                                                             17.504                                                                             26.103                                                                             1.00                                                                              36.78                                        ATOM  427                                                                               N   LYS                                                                               121                                                                               22.446                                                                             15.552                                                                             26.650                                                                             1.00                                                                              40.87                                        ATOM  428                                                                               CA  LYS                                                                               121                                                                               23.558                                                                             15.121                                                                             27.499                                                                             1.00                                                                              44.88                                        ATOM  429                                                                               CB  LYS                                                                               121                                                                               23.203                                                                             15.298                                                                             28.984                                                                             1.00                                                                              52.11                                        ATOM  430                                                                               CG  LYS                                                                               121                                                                               22.708                                                                             16.683                                                                             29.408                                                                             1.00                                                                              62.07                                        ATOM  431                                                                               CD  LYS                                                                               121                                                                               23.801                                                                             17.739                                                                             29.350                                                                             1.00                                                                              69.11                                        ATOM  432                                                                               CE  LYS                                                                               121                                                                               23.201                                                                             19.140                                                                             29.325                                                                             1.00                                                                              73.00                                        ATOM  433                                                                               NZ  LYS                                                                               121                                                                               24.267                                                                             20.155                                                                             29.145                                                                             1.00                                                                              75.31                                        ATOM  434                                                                               C   LYS                                                                               121                                                                               23.918                                                                             13.656                                                                             27.293                                                                             1.00                                                                              42.40                                        ATOM  435                                                                               O   LYS                                                                               121                                                                               23.043                                                                             12.839                                                                             26.977                                                                             1.00                                                                              40.70                                        ATOM  436                                                                               N   ILE                                                                               122                                                                               25.207                                                                             13.344                                                                             27.464                                                                             1.00                                                                              39.16                                        ATOM  437                                                                               CA  ILE                                                                               122                                                                               25.722                                                                             11.972                                                                             27.363                                                                             1.00                                                                              38.99                                        ATOM  438                                                                               CB  ILE                                                                               122                                                                               27.239                                                                             11.901                                                                             27.043                                                                             1.00                                                                              36.73                                        ATOM  439                                                                               CG2 ILE                                                                               122                                                                               27.612                                                                             10.470                                                                             26.694                                                                             1.00                                                                              33.96                                        ATOM  440                                                                               CG1 ILE                                                                               122                                                                               27.617                                                                             12.828                                                                             25.893                                                                             1.00                                                                              34.62                                        ATOM  441                                                                               CD1 ILE                                                                               122                                                                               29.092                                                                             13.137                                                                             25.858                                                                             1.00                                                                              27.87                                        ATOM  442                                                                               C   ILE                                                                               122                                                                               35.575                                                                             11.413                                                                             28.777                                                                             1.00                                                                              39.57                                        ATOM  443                                                                               O   ILE                                                                               122                                                                               26.043                                                                             12.018                                                                             29.743                                                                             1.00                                                                              39.64                                        ATOM  444                                                                               N   GLU                                                                               123                                                                               24.978                                                                             10.245                                                                             28.921                                                                             1.00                                                                              40.10                                        ATOM  445                                                                               CA  GLU                                                                               123                                                                               24.814                                                                             9.750                                                                              30.259                                                                             1.00                                                                              44.03                                        ATOM  446                                                                               CB  GLU                                                                               123                                                                               23.874                                                                             8.566                                                                              30.281                                                                             1.00                                                                              49.74                                        ATOM  447                                                                               CG  GLU                                                                               123                                                                               22.459                                                                             8.971                                                                              29.925                                                                             1.00                                                                              60.66                                        ATOM  448                                                                               CD  GLU                                                                               123                                                                               21.423                                                                             7.983                                                                              30.411                                                                             1.00                                                                              71.25                                        ATOM  449                                                                               OE1 GLU                                                                               123                                                                               21.199                                                                             6.953                                                                              29.724                                                                             1.00                                                                              75.21                                        ATOM  450                                                                               OE2 GLU                                                                               123                                                                               20.830                                                                             8.246                                                                              31.486                                                                             1.00                                                                              77.91                                        ATOM  451                                                                               C   GLU                                                                               123                                                                               26.138                                                                             9.462                                                                              30.922                                                                             1.00                                                                              45.02                                        ATOM  452                                                                               O   GLU                                                                               123                                                                               27.136                                                                             9.236                                                                              30.249                                                                             1.00                                                                              46.99                                        ATOM  453                                                                               N   GLU                                                                               124                                                                               26.143                                                                             9.520                                                                              32.248                                                                             1.00                                                                              45.66                                        ATOM  454                                                                               CA  GLU                                                                               124                                                                               27.336                                                                             9.291                                                                              33.050                                                                             1.00                                                                              46.67                                        ATOM  455                                                                               CB  GLU                                                                               124                                                                               26.985                                                                             9.301                                                                              34.547                                                                             1.00                                                                              58.31                                        ATOM  456                                                                               CG  GLU                                                                               124                                                                               26.307                                                                             8.014                                                                              35.136                                                                             1.00                                                                              79.38                                        ATOM  457                                                                               CD  GLU                                                                               124                                                                               24.862                                                                             7.728                                                                              34.639                                                                             1.00                                                                              88.11                                        ATOM  458                                                                               OE1 GLU                                                                               124                                                                               24.036                                                                             8.669                                                                              34.506                                                                             1.00                                                                              93.57                                        ATOM  459                                                                               OE2 GLU                                                                               124                                                                               24.545                                                                             6.535                                                                              34.414                                                                             1.00                                                                              92.35                                        ATOM  460                                                                               C   GLU                                                                               124                                                                               28.184                                                                             8.059                                                                              32.716                                                                             1.00                                                                              43.44                                        ATOM  461                                                                               O   GLU                                                                               124                                                                               29.398                                                                             8.182                                                                              32.541                                                                             1.00                                                                              41.19                                        ATOM  462                                                                               N   TYR                                                                               125                                                                               27.564                                                                             6.882                                                                              32.624                                                                             1.00                                                                              39.19                                        ATOM  463                                                                               CA  TYR                                                                               125                                                                               28.305                                                                             5.654                                                                              32.342                                                                             1.00                                                                              38.90                                        ATOM  464                                                                               CB  TYR                                                                               125                                                                               27.362                                                                             4.460                                                                              32.153                                                                             1.00                                                                              41.22                                        ATOM  465                                                                               CG  TYR                                                                               125                                                                               26.336                                                                             4.629                                                                              31.048                                                                             1.00                                                                              52.24                                        ATOM  466                                                                               CD1 TYR                                                                               125                                                                               26.540                                                                             4.059                                                                              29.789                                                                             1.00                                                                              57.21                                        ATOM  467                                                                               CE1 TYR                                                                               125                                                                               25.616                                                                             4.229                                                                              28.750                                                                             1.00                                                                              62.24                                        ATOM  468                                                                               CD2 TYR                                                                               125                                                                               25.169                                                                             5.373                                                                              31.251                                                                             1.00                                                                              54.99                                        ATOM  469                                                                               CE2 TYR                                                                               125                                                                               24.236                                                                             5.548                                                                              30.224                                                                             1.00                                                                              60.71                                        ATOM  470                                                                               CZ  TYR                                                                               125                                                                               24.464                                                                             4.976                                                                              28.970                                                                             1.00                                                                              65.04                                        ATOM  471                                                                               OH  TYR                                                                               125                                                                               23.562                                                                             5.164                                                                              27.932                                                                             1.00                                                                              65.65                                        ATOM  472                                                                               C   TYR                                                                               125                                                                               29.176                                                                             5.833                                                                              31.120                                                                             1.00                                                                              38.81                                        ATOM  473                                                                               O   TYR                                                                               125                                                                               30.398                                                                             5.774                                                                              31.198                                                                             1.00                                                                              39.40                                        ATOM  474                                                                               N   ALA                                                                               126                                                                               28.529                                                                             6.200                                                                              30.025                                                                             1.00                                                                              38.18                                        ATOM  475                                                                               CA  ALA                                                                               126                                                                               29.189                                                                             6.395                                                                              28.759                                                                             1.00                                                                              35.81                                        ATOM  476                                                                               CB  ALA                                                                               126                                                                               28.160                                                                             6.777                                                                              27.715                                                                             1.00                                                                              36.47                                        ATOM  477                                                                               C   ALA                                                                               126                                                                               30.300                                                                             7.438                                                                              28.836                                                                             1.00                                                                              35.33                                        ATOM  478                                                                               O   ALA                                                                               126                                                                               31.416                                                                             7.184                                                                              28.390                                                                             1.00                                                                              39.00                                        ATOM  479                                                                               N   LYS                                                                               127                                                                               30.015                                                                             8.575                                                                              29.457                                                                             1.00                                                                              33.83                                        ATOM  480                                                                               CA  LYS                                                                               127                                                                               30.979                                                                             9.666                                                                              29.580                                                                             1.00                                                                              36.03                                        ATOM  481                                                                               CB  LYS                                                                               127                                                                               30.264                                                                             10.897                                                                             30.143                                                                             1.00                                                                              37.06                                        ATOM  482                                                                               CG  LYS                                                                               127                                                                               30.934                                                                             12.227                                                                             29.859                                                                             1.00                                                                              44.50                                        ATOM  483                                                                               CD  LYS                                                                               127                                                                               29.936                                                                             13.399                                                                             30.033                                                                             1.00                                                                              50.75                                        ATOM  484                                                                               CE  LYS                                                                               127                                                                               30.562                                                                             14.783                                                                             29.762                                                                             1.00                                                                              49.31                                        ATOM  485                                                                               NZ  LYS                                                                               127                                                                               29.576                                                                             15.897                                                                             29.940                                                                             1.00                                                                              48.12                                        ATOM  486                                                                               C   LYS                                                                               127                                                                               32.235                                                                             9.330                                                                              30.412                                                                             1.00                                                                              38.28                                        ATOM  487                                                                               O   LYS                                                                               127                                                                               33.350                                                                             9.752                                                                              30.084                                                                             1.00                                                                              39.37                                        ATOM  488                                                                               N   SER                                                                               128                                                                               32.086                                                                             8.557                                                                              31.479                                                                             1.00                                                                              38.74                                        ATOM  489                                                                               CA  SER                                                                               128                                                                               33.262                                                                             8.242                                                                              32.281                                                                             1.00                                                                              40.98                                        ATOM  490                                                                               CB  SER                                                                               128                                                                               32.863                                                                             7.861                                                                              33.705                                                                             1.00                                                                              43.21                                        ATOM  491                                                                               OG  SER                                                                               128                                                                               31.778                                                                             6.953                                                                              33.707                                                                             1.00                                                                              54.17                                        ATOM  492                                                                               C   SER                                                                               128                                                                               34.102                                                                             7.155                                                                              31.621                                                                             1.00                                                                              39.36                                        ATOM  493                                                                               O   SER                                                                               128                                                                               35.335                                                                             7.178                                                                              31.674                                                                             1.00                                                                              38.65                                        ATOM  494                                                                               N   LYS                                                                               129                                                                               33.421                                                                             6.238                                                                              30.946                                                                             1.00                                                                              37.47                                        ATOM  495                                                                               CA  LYS                                                                               129                                                                               34.081                                                                             5.145                                                                              30.254                                                                             1.00                                                                              35.27                                        ATOM  496                                                                               CB  LYS                                                                               129                                                                               33.027                                                                             4.216                                                                              29.643                                                                             1.00                                                                              37.51                                        ATOM  497                                                                               CG  LYS                                                                               129                                                                               33.446                                                                             2.768                                                                              29.510                                                                             1.00                                                                              41.85                                        ATOM  498                                                                               CD  LYS                                                                               129                                                                               34.432                                                                             2.565                                                                              28.374                                                                             1.00                                                                              51.04                                        ATOM  499                                                                               CE  LYS                                                                               129                                                                               35.429                                                                             1.457                                                                              28.704                                                                             1.00                                                                              55.30                                        ATOM  500                                                                               NZ  LYS                                                                               129                                                                               36.243                                                                             1.784                                                                              29.934                                                                             1.00                                                                              58.49                                        ATOM  501                                                                               C   LYS                                                                               129                                                                               34.967                                                                             5.782                                                                              29.186                                                                             1.00                                                                              33.07                                        ATOM  502                                                                               O   LYS                                                                               129                                                                               36.155                                                                             5.469                                                                              29.070                                                                             1.00                                                                              33.07                                        ATOM  503                                                                               N   ALA                                                                               130                                                                               34.415                                                                             6.740                                                                              28.460                                                                             1.00                                                                              29.50                                        ATOM  504                                                                               CA  ALA                                                                               130                                                                               35.192                                                                             7.414                                                                              27.438                                                                             1.00                                                                              26.51                                        ATOM  505                                                                               CB  ALA                                                                               130                                                                               34.335                                                                             8.429                                                                              26.699                                                                             1.00                                                                              27.54                                        ATOM  506                                                                               C   ALA                                                                               130                                                                               36.425                                                                             8.081                                                                              28.055                                                                             1.00                                                                              25.32                                        ATOM  507                                                                               O   ALA                                                                               130                                                                               37.531                                                                             7.871                                                                              27.566                                                                             1.00                                                                              29.93                                        ATOM  508                                                                               N   LEU                                                                               131                                                                               36.262                                                                             8.868                                                                              29.119                                                                             1.00                                                                              21.01                                        ATOM  509                                                                               CA  LEU                                                                               131                                                                               37.420                                                                             9.508                                                                              29.745                                                                             1.00                                                                              18.71                                        ATOM  510                                                                               CB  LEU                                                                               131                                                                               36.993                                                                             10.317                                                                             30.944                                                                             1.00                                                                              19.17                                        ATOM  511                                                                               CG  LEU                                                                               131                                                                               36.275                                                                             11.598                                                                             30.568                                                                             1.00                                                                              28.02                                        ATOM  512                                                                               CD1 LEU                                                                               131                                                                               35.753                                                                             12.262                                                                             31.826                                                                             1.00                                                                              32.84                                        ATOM  513                                                                               CD2 LEU                                                                               131                                                                               37.217                                                                             12.538                                                                             29.844                                                                             1.00                                                                              26.14                                        ATOM  514                                                                               C   LEU                                                                               131                                                                               38.480                                                                             8.503                                                                              30.189                                                                             1.00                                                                              21.44                                        ATOM  515                                                                               O   LEU                                                                               131                                                                               39.676                                                                             8.813                                                                              30.234                                                                             1.00                                                                              22.24                                        ATOM  516                                                                               N   ALA                                                                               132                                                                               38.030                                                                             7.311                                                                              30.557                                                                             1.00                                                                              22.62                                        ATOM  517                                                                               CA  ALA                                                                               132                                                                               38.917                                                                             6.236                                                                              30.997                                                                             1.00                                                                              27.46                                        ATOM  518                                                                               CB  ALA                                                                               132                                                                               38.089                                                                             5.090                                                                              31.584                                                                             1.00                                                                              24.97                                        ATOM  519                                                                               C   ALA                                                                               132                                                                               39.780                                                                             5.720                                                                              29.838                                                                             1.00                                                                              28.21                                        ATOM  520                                                                               O   ALA                                                                               132                                                                               41.021                                                                             5.616                                                                              29.962                                                                             1.00                                                                              28.54                                        ATOM  521                                                                               N   GLU                                                                               133                                                                               39.113                                                                             5.395                                                                              28.725                                                                             1.00                                                                              24.88                                        ATOM  522                                                                               CA  GLU                                                                               133                                                                               37.788                                                                             4.906                                                                              27.534                                                                             1.00                                                                              21.77                                        ATOM  523                                                                               CB  GLU                                                                               133                                                                               38.806                                                                             4.655                                                                              26.394                                                                             1.00                                                                              20.10                                        ATOM  524                                                                               CG  GLU                                                                               133                                                                               37.982                                                                             3.382                                                                              26.535                                                                             1.00                                                                              22.13                                        ATOM  525                                                                               CD  GLU                                                                               133                                                                               38.836                                                                             2.133                                                                              26.735                                                                             1.00                                                                              29.26                                        ATOM  526                                                                               OE1 GLU                                                                               133                                                                               39.035                                                                             1.721                                                                              27.897                                                                             1.00                                                                              32.94                                        ATOM  527                                                                               OE2 GLU                                                                               133                                                                               39.303                                                                             1.555                                                                              35.733                                                                             1.00                                                                              33.24                                        ATOM  528                                                                               C   GLU                                                                               133                                                                               40.798                                                                             5.938                                                                              27.135                                                                             1.00                                                                              22.44                                        ATOM  529                                                                               O   GLU                                                                               133                                                                               41.963                                                                             5.613                                                                              26.908                                                                             1.00                                                                              25.37                                        ATOM  530                                                                               N   LEU                                                                               134                                                                               40.367                                                                             7.198                                                                              27.137                                                                             1.00                                                                              25.68                                        ATOM  531                                                                               CA  LEU                                                                               134                                                                               41.237                                                                             8.330                                                                              26.794                                                                             1.00                                                                              27.08                                        ATOM  532                                                                               CB  LEU                                                                               134                                                                               40.439                                                                             9.650                                                                              26.759                                                                             1.00                                                                              25.70                                        ATOM  533                                                                               CG  LEU                                                                               134                                                                               39.500                                                                             9.925                                                                              25.573                                                                             1.00                                                                              24.82                                        ATOM  534                                                                               CD1 LEU                                                                               134                                                                               38.672                                                                             11.152                                                                             25.847                                                                             1.00                                                                              26.04                                        ATOM  535                                                                               CD2 LEU                                                                               134                                                                               40.285                                                                             10.101                                                                             24.281                                                                             1.00                                                                              23.46                                        ATOM  536                                                                               C   LEU                                                                               134                                                                               42.452                                                                             8.459                                                                              27.732                                                                             1.00                                                                              28.99                                        ATOM  537                                                                               O   LEU                                                                               134                                                                               43.526                                                                             8.874                                                                              27.296                                                                             1.00                                                                              31.43                                        ATOM  538                                                                               N   GLN                                                                               135                                                                               42.298                                                                             8.100                                                                              29.007                                                                             1.00                                                                              29.30                                        ATOM  539                                                                               CA  GLN                                                                               135                                                                               43.416                                                                             8.184                                                                              29.933                                                                             1.00                                                                              24.79                                        ATOM  540                                                                               CB  GLN                                                                               135                                                                               42.984                                                                             7.936                                                                              31.359                                                                             1.00                                                                              37.17                                        ATOM  541                                                                               CG  GLN                                                                               135                                                                               44.183                                                                             7.664                                                                              32.243                                                                             1.00                                                                              50.15                                        ATOM  542                                                                               CD  GLN                                                                               135                                                                               43.898                                                                             7.810                                                                              33.710                                                                             1.00                                                                              57.04                                        ATOM  543                                                                               OE1 GLN                                                                               135                                                                               44.561                                                                             8.593                                                                              34.395                                                                             1.00                                                                              60.77                                        ATOM  544                                                                               NE2 GLN                                                                               135                                                                               42.938                                                                             7.036                                                                              34.218                                                                             1.00                                                                              62.19                                        ATOM  545                                                                               C   GLN                                                                               135                                                                               44.445                                                                             7.154                                                                              29.565                                                                             1.00                                                                              19.79                                        ATOM  546                                                                               O   GLN                                                                               135                                                                               45.643                                                                             7.431                                                                              29.595                                                                             1.00                                                                              19.13                                        ATOM  547                                                                               N   GLY                                                                               136                                                                               43.983                                                                             5.944                                                                              29.286                                                                             1.00                                                                              18.03                                        ATOM  548                                                                               CA  GLY                                                                               136                                                                               44.901                                                                             4.890                                                                              28.879                                                                             1.00                                                                              21.15                                        ATOM  549                                                                               C   GLY                                                                               136                                                                               45.595                                                                             5.199                                                                              27.543                                                                             1.00                                                                              21.95                                        ATOM  550                                                                               O   GLY                                                                               136                                                                               46.760                                                                             4.862                                                                              27.338                                                                             1.00                                                                              20.39                                        ATOM  551                                                                               N   LEU                                                                               137                                                                               44.887                                                                             5.863                                                                              26.636                                                                             1.00                                                                              17.33                                        ATOM  552                                                                               CA  LEU                                                                               137                                                                               45.450                                                                             6.204                                                                              25.348                                                                             1.00                                                                              17.93                                        ATOM  553                                                                               CB  LEU                                                                               137                                                                               44.346                                                                             6.640                                                                              24.382                                                                             1.00                                                                              20.38                                        ATOM  554                                                                               CG  LEU                                                                               137                                                                               43.472                                                                             5.486                                                                              23.897                                                                             1.00                                                                              17.15                                        ATOM  555                                                                               CD1 LEU                                                                               137                                                                               42.219                                                                             5.983                                                                              23.217                                                                             1.00                                                                              22.09                                        ATOM  556                                                                               CD2 LEU                                                                               137                                                                               44.292                                                                             4.635                                                                              22.970                                                                             1.00                                                                              19.05                                        ATOM  557                                                                               C   LEU                                                                               137                                                                               46.527                                                                             7.259                                                                              25.439                                                                             1.00                                                                              18.12                                        ATOM  558                                                                               O   LEU                                                                               137                                                                               47.564                                                                             7.143                                                                              24.799                                                                             1.00                                                                              20.83                                        ATOM  559                                                                               N   GLN                                                                               138                                                                               46.294                                                                             8.293                                                                              26.231                                                                             1.00                                                                              19.01                                        ATOM  560                                                                               CA  GLN                                                                               138                                                                               47.274                                                                             9.364                                                                              26.373                                                                             1.00                                                                              23.17                                        ATOM  561                                                                               CB  GLN                                                                               138                                                                               46.756                                                                             10.428                                                                             27.354                                                                             1.00                                                                              29.42                                        ATOM  562                                                                               CG  GLN                                                                               138                                                                               47.680                                                                             11.615                                                                             27.608                                                                             1.00                                                                              33.61                                        ATOM  563                                                                               CD  GLN                                                                               138                                                                               48.671                                                                             11.359                                                                             28.736                                                                             1.00                                                                              38.81                                        ATOM  564                                                                               OE1 GLN                                                                               138                                                                               49.881                                                                             11.383                                                                             28.525                                                                             1.00                                                                              43.59                                        ATOM  565                                                                               NE2 GLN                                                                               138                                                                               48.161                                                                             11.112                                                                             29.938                                                                             1.00                                                                              40.08                                        ATOM  566                                                                               C   GLN                                                                               138                                                                               48.581                                                                             8.777                                                                              26.854                                                                             1.00                                                                              24.66                                        ATOM  567                                                                               O   GLN                                                                               138                                                                               49.654                                                                             9.111                                                                              26.359                                                                             1.00                                                                              26.00                                        ATOM  568                                                                               N   ASN                                                                               139                                                                               48.464                                                                             7.858                                                                              27.796                                                                             1.00                                                                              24.89                                        ATOM  569                                                                               CA  ASN                                                                               139                                                                               49.614                                                                             7.203                                                                              28.376                                                                             1.00                                                                              26.38                                        ATOM  570                                                                               CB  ASN                                                                               139                                                                               49.127                                                                             6.275                                                                              29.474                                                                             1.00                                                                              28.88                                        ATOM  571                                                                               CG  ASN                                                                               139                                                                               50.211                                                                             5.915                                                                              30.436                                                                             1.00                                                                              33.91                                        ATOM  572                                                                               OD1 ASN                                                                               139                                                                               50.747                                                                             4.798                                                                              30.407                                                                             1.00                                                                              29.67                                        ATOM  573                                                                               ND2 ASN                                                                               139                                                                               50.554                                                                             6.863                                                                              31.305                                                                             1.00                                                                              34.35                                        ATOM  574                                                                               C   ASN                                                                               139                                                                               50.432                                                                             6.422                                                                              27.328                                                                             1.00                                                                              29.07                                        ATOM  575                                                                               O   ASN                                                                               139                                                                               51.619                                                                             6.706                                                                              27.106                                                                             1.00                                                                              30.84                                        ATOM  576                                                                               N   ASN                                                                               140                                                                               49.788                                                                             5.453                                                                              26.674                                                                             1.00                                                                              27.61                                        ATOM  577                                                                               CA  ASN                                                                               140                                                                               50.425                                                                             4.631                                                                              25.647                                                                             1.00                                                                              26.41                                        ATOM  578                                                                               CB  ASN                                                                               140                                                                               49.382                                                                             3.763                                                                              24.947                                                                             1.00                                                                              28.07                                        ATOM  579                                                                               CG  ASN                                                                               140                                                                               49.055                                                                             2.524                                                                              25.706                                                                             1.00                                                                              26.17                                        ATOM  580                                                                               OD1 ASN                                                                               140                                                                               47.969                                                                             1.982                                                                              25.586                                                                             1.00                                                                              33.30                                        ATOM  581                                                                               ND2 ASN                                                                               140                                                                               50.001                                                                             2.042                                                                              26.471                                                                             1.00                                                                              34.68                                        ATOM  582                                                                               C   ASN                                                                               140                                                                               51.102                                                                             5.492                                                                              24.594                                                                             1.00                                                                              30.46                                        ATOM  583                                                                               O   ASN                                                                               140                                                                               52.269                                                                             5.266                                                                              24.217                                                                             1.00                                                                              31.28                                        ATOM  584                                                                               N   PHE                                                                               141                                                                               50.332                                                                             6.462                                                                              24.106                                                                             1.00                                                                              30.47                                        ATOM  585                                                                               CA  PHE                                                                               141                                                                               50.777                                                                             7.375                                                                              23.083                                                                             1.00                                                                              26.60                                        ATOM  586                                                                               CB  PHE                                                                               141                                                                               49.643                                                                             8.294                                                                              22.656                                                                             1.00                                                                              23.65                                        ATOM  587                                                                               CG  PHE                                                                               141                                                                               50.001                                                                             9.127                                                                              21.500                                                                             1.00                                                                              23.59                                        ATOM  588                                                                               CD1 PHE                                                                               141                                                                               50.354                                                                             8.532                                                                              20.302                                                                             1.00                                                                              19.79                                        ATOM  589                                                                               CD2 PHE                                                                               141                                                                               50.123                                                                             10.503                                                                             21.631                                                                             1.00                                                                              25.06                                        ATOM  590                                                                               CE1 PHE                                                                               141                                                                               50.840                                                                             9.269                                                                              19.254                                                                             1.00                                                                              21.84                                        ATOM  591                                                                               CE2 PHE                                                                               141                                                                               50.612                                                                             11.264                                                                             20.582                                                                             1.00                                                                              22.29                                        ATOM  592                                                                               CZ  PHE                                                                               141                                                                               50.974                                                                             10.640                                                                             19.391                                                                             1.00                                                                              18.99                                        ATOM  593                                                                               C   PHE                                                                               141                                                                               51.970                                                                             8.192                                                                              23.519                                                                             1.00                                                                              26.32                                        ATOM  594                                                                               O   PHE                                                                               141                                                                               52.962                                                                             8.285                                                                              22.790                                                                             1.00                                                                              28.72                                        ATOM  595                                                                               N   GLU                                                                               142                                                                               51.900                                                                             8.774                                                                              24.710                                                                             1.00                                                                              26.35                                        ATOM  596                                                                               CA  GLU                                                                               142                                                                               53.025                                                                             9.568                                                                              25.197                                                                             1.00                                                                              26.18                                        ATOM  597                                                                               CB  GLU                                                                               142                                                                               52.657                                                                             10.297                                                                             26.484                                                                             1.00                                                                              26.40                                        ATOM  598                                                                               CG  GLU                                                                               142                                                                               53.828                                                                             11.060                                                                             27.085                                                                             1.00                                                                              34.98                                        ATOM  599                                                                               CD  GLU                                                                               142                                                                               53.429                                                                             12.038                                                                             28.189                                                                             1.00                                                                              38.85                                        ATOM  600                                                                               OE1 GLU                                                                               142                                                                               52.358                                                                             11.876                                                                             28.826                                                                             1.00                                                                              40.50                                        ATOM  601                                                                               OE2 GLU                                                                               142                                                                               54.209                                                                             12.985                                                                             28.417                                                                             1.00                                                                              41.79                                        ATOM  602                                                                               C   GLU                                                                               142                                                                               54.265                                                                             8.680                                                                              25.387                                                                             1.00                                                                              25.06                                        ATOM  603                                                                               O   GLU                                                                               142                                                                               55.394                                                                             9.097                                                                              25.125                                                                             1.00                                                                              26.60                                        ATOM  604                                                                               N   ASP                                                                               143                                                                               54.045                                                                             7.451                                                                              25.836                                                                             1.00                                                                              25.61                                        ATOM  605                                                                               CA  ASP                                                                               143                                                                               55.118                                                                             6.494                                                                              26.029                                                                             1.00                                                                              22.86                                        ATOM  606                                                                               CB  ASP                                                                               143                                                                               54.521                                                                             5.161                                                                              26.422                                                                             1.00                                                                              29.76                                        ATOM  607                                                                               CG  ASP                                                                               143                                                                               54.827                                                                             4.793                                                                              27.835                                                                             1.00                                                                              32.84                                        ATOM  608                                                                               OD1 ASP                                                                               143                                                                               55.385                                                                             5.646                                                                              28.546                                                                             1.00                                                                              35.88                                        ATOM  609                                                                               OD2 ASP                                                                               143                                                                               54.524                                                                             3.647                                                                              28.236                                                                             1.00                                                                              38.26                                        ATOM  610                                                                               C   ASP                                                                               143                                                                               55.820                                                                             6.341                                                                              24.704                                                                             1.00                                                                              24.52                                        ATOM  611                                                                               O   ASP                                                                               143                                                                               57.009                                                                             6.642                                                                              24.576                                                                             1.00                                                                              28.26                                        ATOM  612                                                                               N   TYR                                                                               144                                                                               55.039                                                                             5.970                                                                              23.693                                                                             1.00                                                                              22.82                                        ATOM  613                                                                               CA  TYR                                                                               144                                                                               55.536                                                                             5.783                                                                              22.346                                                                             1.00                                                                              17.47                                        ATOM  614                                                                               CB  TYR                                                                               144                                                                               54.379                                                                             5.515                                                                              21.384                                                                             1.00                                                                              18.87                                        ATOM  615                                                                               CG  TYR                                                                               144                                                                               54.755                                                                             5.589                                                                              19.914                                                                             1.00                                                                              20.91                                        ATOM  616                                                                               CD1 TYR                                                                               144                                                                               55.499                                                                             4.573                                                                              19.303                                                                             1.00                                                                              24.91                                        ATOM  617                                                                               CE1 TYR                                                                               144                                                                               55.859                                                                             4.653                                                                              17.944                                                                             1.00                                                                              17.76                                        ATOM  618                                                                               CD2 TYR                                                                               144                                                                               54.376                                                                             6.685                                                                              19.128                                                                             1.00                                                                              26.29                                        ATOM  619                                                                               CE2 TYR                                                                               144                                                                               54.730                                                                             6.764                                                                              17.770                                                                             1.00                                                                              19.32                                        ATOM  620                                                                               CZ  TYR                                                                               144                                                                               55.470                                                                             5.746                                                                              17.200                                                                             1.00                                                                              16.89                                        ATOM  621                                                                               OH  TYR                                                                               144                                                                               55.844                                                                             5.836                                                                              15.895                                                                             1.00                                                                              19.87                                        ATOM  622                                                                               C   TYR                                                                               144                                                                               56.330                                                                             6.977                                                                              21.865                                                                             1.00                                                                              17.93                                        ATOM  623                                                                               O   TYR                                                                               144                                                                               57.437                                                                             6.822                                                                              21.371                                                                             1.00                                                                              17.85                                        ATOM  624                                                                               N   VAL                                                                               145                                                                               55.776                                                                             8.173                                                                              21.987                                                                             1.00                                                                              17.19                                        ATOM  625                                                                               CA  VAL                                                                               145                                                                               56.507                                                                             9.328                                                                              21.509                                                                             1.00                                                                              15.32                                        ATOM  626                                                                               CB  VAL                                                                               145                                                                               55.734                                                                             10.599                                                                             21.731                                                                             1.00                                                                              15.48                                        ATOM  627                                                                               CG1 VAL                                                                               145                                                                               56.622                                                                             11.814                                                                             21.404                                                                             1.00                                                                              13.94                                        ATOM  628                                                                               CG2 VAL                                                                               145                                                                               54.487                                                                             10.570                                                                             20.850                                                                             1.00                                                                              9.58                                         ATOM  629                                                                               C   VAL                                                                               145                                                                               57.896                                                                             9.437                                                                              22.110                                                                             1.00                                                                              20.37                                        ATOM  630                                                                               O   VAL                                                                               145                                                                               58.856                                                                             9.754                                                                              21.405                                                                             1.00                                                                              21.53                                        ATOM  631                                                                               N   ASN                                                                               146                                                                               58.011                                                                             9.115                                                                              23.397                                                                             1.00                                                                              19.99                                        ATOM  632                                                                               CA  ASN                                                                               146                                                                               59.297                                                                             9.165                                                                              24.082                                                                             1.00                                                                              22.23                                        ATOM  633                                                                               CB  ASN                                                                               146                                                                               59.138                                                                             9.071                                                                              25.592                                                                             1.00                                                                              26.65                                        ATOM  634                                                                               CG  ASN                                                                               146                                                                               58.687                                                                             10.375                                                                             26.192                                                                             1.00                                                                              23.52                                        ATOM  635                                                                               OD1 ASN                                                                               146                                                                               58.612                                                                             11.393                                                                             25.506                                                                             1.00                                                                              32.61                                        ATOM  636                                                                               ND2 ASN                                                                               146                                                                               58.371                                                                             10.356                                                                             27.461                                                                             1.00                                                                              33.71                                        ATOM  637                                                                               C   ASN                                                                               146                                                                               60.239                                                                             8.117                                                                              23.584                                                                             1.00                                                                              18.20                                        ATOM  638                                                                               O   ASN                                                                               146                                                                               61.409                                                                             8.405                                                                              23.380                                                                             1.00                                                                              21.90                                        ATOM  639                                                                               N   ALA                                                                               147                                                                               59.743                                                                             6.902                                                                              23.393                                                                             1.00                                                                              17.72                                        ATOM  640                                                                               CA  ALA                                                                               147                                                                               60.559                                                                             5.823                                                                              22.839                                                                             1.00                                                                              17.53                                        ATOM  641                                                                               CB  ALA                                                                               147                                                                               59.754                                                                             4.519                                                                              22.779                                                                             1.00                                                                              17.05                                        ATOM  642                                                                               C   ALA                                                                               147                                                                               60.970                                                                             6.222                                                                              21.417                                                                             1.00                                                                              22.69                                        ATOM  643                                                                               O   ALA                                                                               147                                                                               62.035                                                                             7.026                                                                              20.752                                                                             1.00                                                                              27.83                                        ATOM  644                                                                               N   LEU                                                                               148                                                                               60.142                                                                             7.026                                                                              20.752                                                                             1.00                                                                              24.44                                        ATOM  645                                                                               CA  LEU                                                                               148                                                                               60.442                                                                             7.423                                                                              19.388                                                                             1.00                                                                              25.40                                        ATOM  646                                                                               CB  LEU                                                                               148                                                                               59.180                                                                             7.831                                                                              18.619                                                                             1.00                                                                              22.84                                        ATOM  647                                                                               CG  LEU                                                                               148                                                                               59.406                                                                             8.092                                                                              17.125                                                                             1.00                                                                              22.68                                        ATOM  648                                                                               CD1 LEU                                                                               148                                                                               59.589                                                                             6.805                                                                              16.322                                                                             1.00                                                                              18.18                                        ATOM  649                                                                               CD2 LEU                                                                               148                                                                               58.268                                                                             8.886                                                                              16.582                                                                             1.00                                                                              20.06                                        ATOM  650                                                                               C   LEU                                                                               148                                                                               61.480                                                                             8.508                                                                              19.308                                                                             1.00                                                                              24.34                                        ATOM  651                                                                               O   LEU                                                                               148                                                                               62.312                                                                             8.462                                                                              18.435                                                                             1.00                                                                              27.64                                        ATOM  652                                                                               N   ASN                                                                               149                                                                               61.474                                                                             9.465                                                                              20.222                                                                             1.00                                                                              28.78                                        ATOM  653                                                                               CA  ASN                                                                               149                                                                               62.475                                                                             10.523                                                                             20.146                                                                             1.00                                                                              31.28                                        ATOM  654                                                                               CB  ASN                                                                               149                                                                               62.232                                                                             11.613                                                                             21.192                                                                             1.00                                                                              43.55                                        ATOM  655                                                                               CG  ASN                                                                               149                                                                               60.975                                                                             12.457                                                                             20.898                                                                             1.00                                                                              55.36                                        ATOM  656                                                                               OD1 ASN                                                                               149                                                                               60.817                                                                             13.032                                                                             19.802                                                                             1.00                                                                              60.56                                        ATOM  657                                                                               ND2 ASN                                                                               149                                                                               60.085                                                                             12.545                                                                             21.883                                                                             1.00                                                                              62.05                                        ATOM  658                                                                               C   ASN                                                                               149                                                                               63.863                                                                             9.936                                                                              20.299                                                                             1.00                                                                              27.77                                        ATOM  659                                                                               O   ASN                                                                               149                                                                               64.797                                                                             10.369                                                                             19.614                                                                             1.00                                                                              25.49                                        ATOM  660                                                                               N   SER                                                                               150                                                                               63.965                                                                             8.917                                                                              21.145                                                                             1.00                                                                              27.48                                        ATOM  661                                                                               CA  SER                                                                               150                                                                               65.212                                                                             8.206                                                                              21.414                                                                             1.00                                                                              29.75                                        ATOM  662                                                                               CB  SER                                                                               150                                                                               64.979                                                                             7.102                                                                              22.445                                                                             1.00                                                                              32.71                                        ATOM  663                                                                               OG  SER                                                                               150                                                                               64.942                                                                             7.628                                                                              23.756                                                                             1.00                                                                              35.48                                        ATOM  664                                                                               C   SER                                                                               150                                                                               65.686                                                                             7.543                                                                              20.150                                                                             1.00                                                                              29.64                                        ATOM  665                                                                               O   SER                                                                               150                                                                               66.781                                                                             7.814                                                                              19.661                                                                             1.00                                                                              32.57                                        ATOM  666                                                                               N   TRP                                                                               151                                                                               64.841                                                                             6.652                                                                              19.645                                                                             1.00                                                                              27.07                                        ATOM  667                                                                               CA  TRP                                                                               151                                                                               65.092                                                                             5.909                                                                              18.428                                                                             1.00                                                                              25.09                                        ATOM  668                                                                               CB  TRP                                                                               151                                                                               63.811                                                                             5.254                                                                              17.953                                                                             1.00                                                                              24.27                                        ATOM  669                                                                               CG  TRP                                                                               151                                                                               64.046                                                                             4.513                                                                              16.726                                                                             1.00                                                                              25.31                                        ATOM  670                                                                               CD2 TRP                                                                               151                                                                               64.627                                                                             3.213                                                                              16.629                                                                             1.00                                                                              26.75                                        ATOM  671                                                                               CE2 TRP                                                                               151                                                                               64.741                                                                             2.911                                                                              15.259                                                                             1.00                                                                              26.58                                        ATOM  672                                                                               CE3 TRP                                                                               151                                                                               65.068                                                                             2.273                                                                              17.572                                                                             1.00                                                                              30.19                                        ATOM  673                                                                               CD1 TRP                                                                               151                                                                               63.828                                                                             4.940                                                                              15.455                                                                             1.00                                                                              23.89                                        ATOM  674                                                                               NE1 TRP                                                                               151                                                                               64.251                                                                             3.984                                                                              14.560                                                                             1.00                                                                              27.19                                        ATOM  675                                                                               CZ2 TRP                                                                               151                                                                               65.277                                                                             1.708                                                                              14.804                                                                             1.00                                                                              31.26                                        ATOM  676                                                                               CZ3 TRP                                                                               151                                                                               65.600                                                                             1.080                                                                              17.127                                                                             1.00                                                                              29.51                                        ATOM  677                                                                               CH2 TRP                                                                               151                                                                               65.702                                                                             0.807                                                                              15.754                                                                             1.00                                                                              32.46                                        ATOM  678                                                                               C   TRP                                                                               151                                                                               65.606                                                                             6.787                                                                              17.310                                                                             1.00                                                                              26.40                                        ATOM  679                                                                               O   TRP                                                                               151                                                                               66.545                                                                             6.421                                                                              16.590                                                                             1.00                                                                              30.03                                        ATOM  680                                                                               N   LYS                                                                               152                                                                               64.935                                                                             7.913                                                                              17.111                                                                             1.00                                                                              27.05                                        ATOM  681                                                                               CA  LYS                                                                               152                                                                               65.321                                                                             8.844                                                                              16.072                                                                             1.00                                                                              27.57                                        ATOM  682                                                                               CB  LYS                                                                               152                                                                               64.293                                                                             9.955                                                                              15.937                                                                             1.00                                                                              27.96                                        ATOM  683                                                                               CG  LYS                                                                               152                                                                               63.159                                                                             9.635                                                                              15.008                                                                             1.00                                                                              30.45                                        ATOM  684                                                                               CD  LYS                                                                               152                                                                               62.571                                                                             10.919                                                                             14.428                                                                             1.00                                                                              36.14                                        ATOM  685                                                                               CE  LYS                                                                               152                                                                               61.524                                                                             11.548                                                                             15.340                                                                             1.00                                                                              36.97                                        ATOM  686                                                                               NZ  LYS                                                                               152                                                                               61.646                                                                             13.036                                                                             15.381                                                                             1.00                                                                              44.84                                        ATOM  687                                                                               C   LYS                                                                               152                                                                               66.694                                                                             9.439                                                                              16.310                                                                             1.00                                                                              28.93                                        ATOM  688                                                                               O   LYS                                                                               152                                                                               67.394                                                                             9.733                                                                              15.345                                                                             1.00                                                                              26.55                                        ATOM  689                                                                               N   LYS                                                                               153                                                                               67.041                                                                             9.670                                                                              17.580                                                                             1.00                                                                              30.64                                        ATOM  690                                                                               CA  LYS                                                                               153                                                                               68.340                                                                             10.245                                                                             17.974                                                                             1.00                                                                              36.17                                        ATOM  691                                                                               CB  LYS                                                                               153                                                                               68.280                                                                             10.789                                                                             19.406                                                                             1.00                                                                              44.14                                        ATOM  692                                                                               CG  LYS                                                                               153                                                                               67.324                                                                             11.951                                                                             19.642                                                                             1.00                                                                              56.90                                        ATOM  693                                                                               CD  LYS                                                                               153                                                                               67.670                                                                             12.702                                                                             20.941                                                                             1.00                                                                              62.05                                        ATOM  694                                                                               CE  LYS                                                                               153                                                                               69.028                                                                             13.431                                                                             20.818                                                                             1.00                                                                              65.84                                        ATOM  695                                                                               NZ  LYS                                                                               153                                                                               69.403                                                                             14.260                                                                             22.014                                                                             1.00                                                                              64.03                                        ATOM  696                                                                               C   LYS                                                                               153                                                                               69.533                                                                             9.282                                                                              17.935                                                                             1.00                                                                              34.62                                        ATOM  697                                                                               O   LYS                                                                               153                                                                               70.681                                                                             9.709                                                                              17.901                                                                             1.00                                                                              35.40                                        ATOM  698                                                                               N   THR                                                                               154                                                                               69.254                                                                             7.989                                                                              17.993                                                                             1.00                                                                              35.88                                        ATOM  699                                                                               CA  THR                                                                               154                                                                               70.279                                                                             6.950                                                                              18.024                                                                             1.00                                                                              34.95                                        ATOM  700                                                                               CB  THR                                                                               154                                                                               69.638                                                                             5.639                                                                              18.516                                                                             1.00                                                                              35.22                                        ATOM  701                                                                               OG1 THR                                                                               154                                                                               68.842                                                                             5.912                                                                              19.685                                                                             1.00                                                                              39.37                                        ATOM  702                                                                               CG2 THR                                                                               154                                                                               70.694                                                                             4.616                                                                              18.877                                                                             1.00                                                                              38.14                                        ATOM  703                                                                               C   THR                                                                               154                                                                               71.081                                                                             6.675                                                                              16.748                                                                             1.00                                                                              34.92                                        ATOM  704                                                                               O   THR                                                                               154                                                                               70.503                                                                             6.360                                                                              15.704                                                                             1.00                                                                              34.58                                        ATOM  705                                                                               N   PRO                                                                               155                                                                               72.431                                                                             6.800                                                                              16.813                                                                             1.00                                                                              35.68                                        ATOM  706                                                                               CD  PRO                                                                               155                                                                               73.289                                                                             7.214                                                                              17.941                                                                             1.00                                                                              32.28                                        ATOM  707                                                                               CA  PRO                                                                               155                                                                               73.245                                                                             6.534                                                                              15.621                                                                             1.00                                                                              34.83                                        ATOM  708                                                                               CB  PRO                                                                               155                                                                               74.675                                                                             6.588                                                                              16.169                                                                             1.00                                                                              31.93                                        ATOM  709                                                                               CG  PRO                                                                               155                                                                               74.582                                                                             7.589                                                                              17.249                                                                             1.00                                                                              30.75                                        ATOM  710                                                                               C   PRO                                                                               155                                                                               72.906                                                                             5.122                                                                              15.160                                                                             1.00                                                                              35.09                                        ATOM  711                                                                               O   PRO                                                                               155                                                                               72.585                                                                             4.266                                                                              15.983                                                                             1.00                                                                              35.97                                        ATOM  712                                                                               N   LEU                                                                               156                                                                               72.949                                                                             4.888                                                                              13.852                                                                             1.00                                                                              40.23                                        ATOM  713                                                                               CA  LEU                                                                               156                                                                               72.653                                                                             3.572                                                                              13.284                                                                             1.00                                                                              40.64                                        ATOM  714                                                                               CB  LEU                                                                               156                                                                               72.996                                                                             3.536                                                                              11.799                                                                             1.00                                                                              43.18                                        ATOM  715                                                                               CG  LEU                                                                               156                                                                               72.262                                                                             4.560                                                                              10.936                                                                             1.00                                                                              46.77                                        ATOM  716                                                                               CD1 LEU                                                                               156                                                                               72.581                                                                             4.315                                                                              9.462                                                                              1.00                                                                              50.39                                        ATOM  717                                                                               CD2 LEU                                                                               156                                                                               70.763                                                                             4.465                                                                              11.186                                                                             1.00                                                                              50.02                                        ATOM  718                                                                               C   LEU                                                                               156                                                                               73.488                                                                             2.546                                                                              14.004                                                                             1.00                                                                              40.37                                        ATOM  719                                                                               O   LEU                                                                               156                                                                               72.967                                                                             1.569                                                                              14.514                                                                             1.00                                                                              43.12                                        ATOM  720                                                                               N   SER                                                                               157                                                                               74.782                                                                             2.832                                                                              14.097                                                                             1.00                                                                              41.57                                        ATOM  721                                                                               CA  SER                                                                               157                                                                               75.768                                                                             1.982                                                                              14.772                                                                             1.00                                                                              39.37                                        ATOM  722                                                                               CB  SER                                                                               157                                                                               77.108                                                                             2.720                                                                              14.810                                                                             1.00                                                                              42.46                                        ATOM  723                                                                               OG  SER                                                                               157                                                                               76.917                                                                             4.128                                                                              14.988                                                                             1.00                                                                              48.99                                        ATOM  724                                                                               C   SER                                                                               157                                                                               75.380                                                                             1.580                                                                              16.195                                                                             1.00                                                                              36.81                                        ATOM  725                                                                               O   SER                                                                               157                                                                               75.728                                                                             0.495                                                                              16.662                                                                             1.00                                                                              34.45                                        ATOM  726                                                                               N   LEU                                                                               158                                                                               74.646                                                                             2.443                                                                              16.881                                                                             1.00                                                                              34.52                                        ATOM  727                                                                               CA  LEU                                                                               158                                                                               74.264                                                                             2.133                                                                              18.242                                                                             1.00                                                                              35.24                                        ATOM  728                                                                               CB  LEU                                                                               158                                                                               74.391                                                                             3.371                                                                              19.121                                                                             1.00                                                                              33.75                                        ATOM  729                                                                               CG  LEU                                                                               158                                                                               75.760                                                                             4.029                                                                              19.172                                                                             1.00                                                                              28.13                                        ATOM  730                                                                               CD1 LEU                                                                               158                                                                               75.699                                                                             5.261                                                                              20.058                                                                             1.00                                                                              28.41                                        ATOM  731                                                                               CD2 LEU                                                                               158                                                                               76.758                                                                             3.025                                                                              19.703                                                                             1.00                                                                              28.88                                        ATOM  732                                                                               C   LEU                                                                               158                                                                               72.877                                                                             1.535                                                                              18.402                                                                             1.00                                                                              36.64                                        ATOM  733                                                                               O   LEU                                                                               158                                                                               72.450                                                                             1.284                                                                              19.530                                                                             1.00                                                                              43.40                                        ATOM  734                                                                               N   ARG                                                                               159                                                                               72.156                                                                             1.315                                                                              17.309                                                                             1.00                                                                              34.12                                        ATOM  735                                                                               CA  ARG                                                                               159                                                                               70.816                                                                             0.726                                                                              17.416                                                                             1.00                                                                              34.54                                        ATOM  736                                                                               CB  ARG                                                                               159                                                                               70.002                                                                             1.061                                                                              16.178                                                                             1.00                                                                              35.15                                        ATOM  737                                                                               CG  ARG                                                                               159                                                                               69.756                                                                             2.533                                                                              16.051                                                                             1.00                                                                              36.06                                        ATOM  738                                                                               CD  ARG                                                                               159                                                                               69.290                                                                             2.938                                                                              14.676                                                                             1.00                                                                              35.14                                        ATOM  739                                                                               NE  ARG                                                                               159                                                                               68.887                                                                             4.331                                                                              14.741                                                                             1.00                                                                              38.24                                        ATOM  740                                                                               CZ  ARG                                                                               159                                                                               68.047                                                                             4.902                                                                              13.899                                                                             1.00                                                                              42.17                                        ATOM  741                                                                               NH1 ARG                                                                               159                                                                               67.731                                                                             6.181                                                                              14.043                                                                             1.00                                                                              44.23                                        ATOM  742                                                                               NH2 ARG                                                                               159                                                                               67.537                                                                             4.191                                                                              12.906                                                                             1.00                                                                              45.95                                        ATOM  743                                                                               C   ARG                                                                               159                                                                               70.886                                                                             -0.790                                                                             17.653                                                                             1.00                                                                              32.88                                        ATOM  744                                                                               O   ARG                                                                               159                                                                               71.503                                                                             -1.518                                                                             16.877                                                                             1.00                                                                              36.83                                        ATOM  745                                                                               N   SER                                                                               160                                                                               70.249                                                                             -1.253                                                                             18.723                                                                             1.00                                                                              27.95                                        ATOM  746                                                                               CA  SER                                                                               160                                                                               70.280                                                                             -2.659                                                                             19.105                                                                             1.00                                                                              24.33                                        ATOM  747                                                                               CB  SER                                                                               160                                                                               70.578                                                                             -2.744                                                                             20.595                                                                             1.00                                                                              26.10                                        ATOM  748                                                                               OG  SER                                                                               160                                                                               69.572                                                                             -2.088                                                                             21.356                                                                             1.00                                                                              24.55                                        ATOM  749                                                                               C   SER                                                                               160                                                                               68.982                                                                             -3.386                                                                             18.856                                                                             1.00                                                                              26.96                                        ATOM  750                                                                               O   SER                                                                               160                                                                               67.957                                                                             -2.749                                                                             18.632                                                                             1.00                                                                              31.18                                        ATOM  751                                                                               N   LYS                                                                               161                                                                               68.997                                                                             -4.713                                                                             18.980                                                                             1.00                                                                              27.03                                        ATOM  752                                                                               CA  LYS                                                                               161                                                                               67.781                                                                             -5.503                                                                             18.793                                                                             1.00                                                                              27.02                                        ATOM  753                                                                               CB  LYS                                                                               161                                                                               68.109                                                                             -6.990                                                                             18.781                                                                             1.00                                                                              28.66                                        ATOM  754                                                                               CG  LYS                                                                               161                                                                               69.045                                                                             -7.392                                                                             17.649                                                                             1.00                                                                              40.43                                        ATOM  755                                                                               CD  LYS                                                                               161                                                                               68.316                                                                             -7.505                                                                             16.298                                                                             1.00                                                                              49.88                                        ATOM  756                                                                               CE  LYS                                                                               161                                                                               69.283                                                                             -7.711                                                                             15.104                                                                             1.00                                                                              52.99                                        ATOM  757                                                                               NZ  LYS                                                                               161                                                                               68.622                                                                             -8.340                                                                             13.896                                                                             1.00                                                                              55.88                                        ATOM  758                                                                               C   LYS                                                                               161                                                                               66.810                                                                             -5.196                                                                             19.934                                                                             1.00                                                                              26.74                                        ATOM  759                                                                               O   LYS                                                                               161                                                                               65.596                                                                             -5.320                                                                             19.789                                                                             1.00                                                                              25.11                                        ATOM  760                                                                               N   ARG                                                                               162                                                                               67.369                                                                             -4.805                                                                             21.073                                                                             1.00                                                                              25.21                                        ATOM  761                                                                               CA  ARG                                                                               162                                                                               66.591                                                                             -4.459                                                                             22.257                                                                             1.00                                                                              25.16                                        ATOM  762                                                                               CB  ARG                                                                               162                                                                               67.536                                                                             -4.141                                                                             23.420                                                                             1.00                                                                              27.16                                        ATOM  763                                                                               CG  ARG                                                                               162                                                                               66.939                                                                             -4.222                                                                             24.815                                                                             1.00                                                                              27.89                                        ATOM  764                                                                               CD  ARG                                                                               162                                                                               67.605                                                                             -3.206                                                                             25.743                                                                             1.00                                                                              29.60                                        ATOM  765                                                                               NE  ARG                                                                               162                                                                               67.109                                                                             -1.850                                                                             25.492                                                                             1.00                                                                              28.75                                        ATOM  766                                                                               CZ  ARG                                                                               162                                                                               67.830                                                                             -0.859                                                                             24.963                                                                             1.00                                                                              30.83                                        ATOM  767                                                                               NH1 ARG                                                                               162                                                                               69.101                                                                             -1.050                                                                             24.615                                                                             1.00                                                                              35.66                                        ATOM  768                                                                               NH2 ARG                                                                               162                                                                               67.279                                                                             0.329                                                                              24.765                                                                             1.00                                                                              21.66                                        ATOM  769                                                                               C   ARG                                                                               162                                                                               65.766                                                                             -3.218                                                                             21.909                                                                             1.00                                                                              25.08                                        ATOM  770                                                                               O   ARG                                                                               162                                                                               64.568                                                                             -3.169                                                                             22.173                                                                             1.00                                                                              22.87                                        ATOM  771                                                                               N   SER                                                                               163                                                                               66.421                                                                             -2.236                                                                             21.293                                                                             1.00                                                                              25.20                                        ATOM  772                                                                               CA  SER                                                                               163                                                                               65.768                                                                             -0.997                                                                             20.890                                                                             1.00                                                                              27.25                                        ATOM  773                                                                               CB  SER                                                                               163                                                                               66.762                                                                             -0.043                                                                             20.233                                                                             1.00                                                                              28.12                                        ATOM  774                                                                               OG  SER                                                                               163                                                                               67.671                                                                             0.494                                                                              21.170                                                                             1.00                                                                              33.02                                        ATOM  775                                                                               C   SER                                                                               163                                                                               64.648                                                                             -1.279                                                                             19.911                                                                             1.00                                                                              30.21                                        ATOM  776                                                                               O   SER                                                                               163                                                                               63.576                                                                             -0.691                                                                             20.009                                                                             1.00                                                                              35.47                                        ATOM  777                                                                               N   GLN                                                                               164                                                                               64.913                                                                             -2.159                                                                             18.946                                                                             1.00                                                                              30.80                                        ATOM  778                                                                               CA  GLN                                                                               164                                                                               63.919                                                                             -2.520                                                                             17.938                                                                             1.00                                                                              29.81                                        ATOM  779                                                                               CB  GLN                                                                               164                                                                               64.499                                                                             -3.481                                                                             16.903                                                                             1.00                                                                              31.88                                        ATOM  780                                                                               CG  GLN                                                                               164                                                                               65.539                                                                             -2.859                                                                             15.992                                                                             1.00                                                                              35.34                                        ATOM  781                                                                               CD  GLN                                                                               164                                                                               65.955                                                                             -3.784                                                                             14.866                                                                             1.00                                                                              35.38                                        ATOM  782                                                                               OE1 GLN                                                                               164                                                                               66.055                                                                             -4.994                                                                             15.049                                                                             1.00                                                                              36.50                                        ATOM  783                                                                               NE2 GLN                                                                               164                                                                               66.185                                                                             -3.219                                                                             13.690                                                                             1.00                                                                              37.36                                        ATOM  784                                                                               C   GLN                                                                               164                                                                               62.723                                                                             -3.176                                                                             18.588                                                                             1.00                                                                              27.06                                        ATOM  785                                                                               O   GLN                                                                               164                                                                               61.599                                                                             -2.696                                                                             18.465                                                                             1.00                                                                              28.49                                        ATOM  786                                                                               N   ASP                                                                               165                                                                               62.984                                                                             -4.290                                                                             19.260                                                                             1.00                                                                              27.83                                        ATOM  787                                                                               CA  ASP                                                                               165                                                                               61.962                                                                             -5.043                                                                             19.956                                                                             1.00                                                                              28.49                                        ATOM  788                                                                               CB  ASP                                                                               165                                                                               62.588                                                                             -6.148                                                                             20.822                                                                             1.00                                                                              33.50                                        ATOM  789                                                                               CG  ASP                                                                               165                                                                               63.140                                                                             -7.321                                                                             20.004                                                                             1.00                                                                              38.35                                        ATOM  790                                                                               OD1 ASP                                                                               165                                                                               62.828                                                                             -7.442                                                                             18.802                                                                             1.00                                                                              43.20                                        ATOM  791                                                                               OD2 ASP                                                                               165                                                                               63.886                                                                             -8.152                                                                             20.573                                                                             1.00                                                                              41.86                                        ATOM  792                                                                               C   ASP                                                                               165                                                                               61.123                                                                             -4.118                                                                             20.820                                                                             1.00                                                                              28.33                                        ATOM  793                                                                               O   ASP                                                                               165                                                                               59.900                                                                             -4.146                                                                             20.719                                                                             1.00                                                                              29.40                                        ATOM  794                                                                               N   ARG                                                                               166                                                                               61.748                                                                             -3.267                                                                             21.635                                                                             1.00                                                                              26.02                                        ATOM  795                                                                               CA  ARG                                                                               166                                                                               60.928                                                                             -2.404                                                                             22.453                                                                             1.00                                                                              30.80                                        ATOM  796                                                                               CB  ARG                                                                               166                                                                               61.638                                                                             -1.826                                                                             23.703                                                                             1.00                                                                              41.63                                        ATOM  797                                                                               CG  ARG                                                                               166                                                                               62.815                                                                             -0.854                                                                             23.491                                                                             1.00                                                                              63.41                                        ATOM  798                                                                               CD  ARG                                                                               166                                                                               62.451                                                                             0.565                                                                              22.887                                                                             1.00                                                                              74.62                                        ATOM  799                                                                               NE  ARG                                                                               166                                                                               63.602                                                                             1.218                                                                              22.219                                                                             1.00                                                                              79.94                                        ATOM  800                                                                               CZ  ARG                                                                               166                                                                               63.505                                                                             2.185                                                                              21.299                                                                             1.00                                                                              80.41                                        ATOM  801                                                                               NH1 ARG                                                                               166                                                                               64.607                                                                             2.721                                                                              20.751                                                                             1.00                                                                              81.58                                        ATOM  802                                                                               NH2 ARG                                                                               166                                                                               62.308                                                                             2.607                                                                              20.911                                                                             1.00                                                                              81.81                                        ATOM  803                                                                               C   ARG                                                                               166                                                                               60.132                                                                             -1.356                                                                             21.699                                                                             1.00                                                                              29.00                                        ATOM  804                                                                               O   ARG                                                                               166                                                                               58.930                                                                             -1.280                                                                             21.909                                                                             1.00                                                                              29.60                                        ATOM  805                                                                               N   ILE                                                                               167                                                                               60.738                                                                             -0.608                                                                             20.777                                                                             1.00                                                                              26.06                                        ATOM  806                                                                               CA  ILE                                                                               167                                                                               59.963                                                                             0.394                                                                              20.066                                                                             1.00                                                                              23.75                                        ATOM  807                                                                               CB  ILE                                                                               167                                                                               60.810                                                                             1.191                                                                              19.093                                                                             1.00                                                                              20.38                                        ATOM  808                                                                               CG2 ILE                                                                               167                                                                               61.452                                                                             0.280                                                                              18.112                                                                             1.00                                                                              25.06                                        ATOM  809                                                                               CG1 ILE                                                                               167                                                                               59.951                                                                             2.228                                                                              18.385                                                                             1.00                                                                              20.43                                        ATOM  810                                                                               CD1 ILE                                                                               167                                                                               60.140                                                                             3.600                                                                              18.837                                                                             1.00                                                                              18.35                                        ATOM  811                                                                               C   ILE                                                                               167                                                                               58.753                                                                             -0.248                                                                             19.363                                                                             1.00                                                                              28.10                                        ATOM  812                                                                               O   ILE                                                                               167                                                                               57.628                                                                             0.240                                                                              19.495                                                                             1.00                                                                              29.42                                        ATOM  813                                                                               N   ARG                                                                               168                                                                               58.945                                                                             -1.384                                                                             18.698                                                                             1.00                                                                              28.88                                        ATOM  814                                                                               CA  ARG                                                                               168                                                                               57.817                                                                             -2.048                                                                             18.033                                                                             1.00                                                                              32.17                                        ATOM  815                                                                               CB  ARG                                                                               168                                                                               58.232                                                                             -3.386                                                                             17.437                                                                             1.00                                                                              31.63                                        ATOM  816                                                                               CG  ARG                                                                               168                                                                               58.640                                                                             -3.323                                                                             16.009                                                                             1.00                                                                              37.29                                        ATOM  817                                                                               CD  ARG                                                                               168                                                                               58.832                                                                             -4.719                                                                             15.462                                                                             1.00                                                                              37.37                                        ATOM  818                                                                               NE  ARG                                                                               168                                                                               60.200                                                                             -5.185                                                                             15.647                                                                             1.00                                                                              34.57                                        ATOM  819                                                                               CZ  ARG                                                                               168                                                                               60.529                                                                             -6.378                                                                             16.122                                                                             1.00                                                                              33.36                                        ATOM  820                                                                               NH1 ARG                                                                               168                                                                               61.810                                                                             -6.699                                                                             16.249                                                                             1.00                                                                              34.45                                        ATOM  821                                                                               NH2 ARG                                                                               168                                                                               59.584                                                                             -7.235                                                                             16.487                                                                             1.00                                                                              35.04                                        ATOM  822                                                                               C   ARG                                                                               168                                                                               56.674                                                                             -2.321                                                                             19.000                                                                             1.00                                                                              34.64                                        ATOM  823                                                                               O   ARG                                                                               168                                                                               55.541                                                                             -1.914                                                                             18.769                                                                             1.00                                                                              39.25                                        ATOM  824                                                                               N   GLU                                                                               169                                                                               56.998                                                                             -3.021                                                                             20.079                                                                             1.00                                                                              37.29                                        ATOM  825                                                                               CA  GLU                                                                               169                                                                               56.059                                                                             -3.410                                                                             21.129                                                                             1.00                                                                              39.87                                        ATOM  826                                                                               CB  GLU                                                                               169                                                                               56.860                                                                             -3.956                                                                             22.320                                                                             1.00                                                                              48.72                                        ATOM  827                                                                               CG  GLU                                                                               169                                                                               56.049                                                                             -4.600                                                                             23.449                                                                             1.00                                                                              55.06                                        ATOM  828                                                                               CD  GLU                                                                               169                                                                               56.945                                                                             -5.101                                                                             24.578                                                                             1.00                                                                              57.67                                        ATOM  829                                                                               OE1 GLU                                                                               169                                                                               57.900                                                                             -4.379                                                                             24.949                                                                             1.00                                                                              55.59                                        ATOM  830                                                                               OE2 GLU                                                                               169                                                                               56.692                                                                             -6.214                                                                             25.091                                                                             1.00                                                                              58.16                                        ATOM  831                                                                               C   GLU                                                                               169                                                                               55.181                                                                             -2.250                                                                             21.580                                                                             1.00                                                                              36.09                                        ATOM  832                                                                               O   GLU                                                                               169                                                                               54.004                                                                             -2.425                                                                             21.898                                                                             1.00                                                                              33.57                                        ATOM  833                                                                               N   LEU                                                                               170                                                                               55.781                                                                             -1.069                                                                             21.615                                                                             1.00                                                                              32.71                                        ATOM  834                                                                               CA  LEU                                                                               170                                                                               55.093                                                                             0.135                                                                              22.005                                                                             1.00                                                                              29.32                                        ATOM  835                                                                               CB  LEU                                                                               170                                                                               56.097                                                                             1.231                                                                              22.321                                                                             1.00                                                                              27.42                                        ATOM  836                                                                               CG  LEU                                                                               170                                                                               56.464                                                                             1.321                                                                              23.795                                                                             1.00                                                                              29.26                                        ATOM  837                                                                               CD1 LEU                                                                               170                                                                               57.580                                                                             2.378                                                                              24.032                                                                             1.00                                                                              20.06                                        ATOM  838                                                                               CD2 LEU                                                                               170                                                                               55.165                                                                             1.641                                                                              24.552                                                                             1.00                                                                              25.26                                        ATOM  839                                                                               C   LEU                                                                               170                                                                               54.197                                                                             0.595                                                                              20.893                                                                             1.00                                                                              28.58                                        ATOM  840                                                                               O   LEU                                                                               170                                                                               53.050                                                                             0.943                                                                              21.135                                                                             1.00                                                                              37.18                                        ATOM  841                                                                               N   PHE                                                                               171                                                                               54.709                                                                             0.611                                                                              19.671                                                                             1.00                                                                              24.66                                        ATOM  842                                                                               CA  PHE                                                                               171                                                                               53.899                                                                             1.063                                                                              18.563                                                                             1.00                                                                              22.29                                        ATOM  843                                                                               CB  PHE                                                                               171                                                                               54.699                                                                             1.053                                                                              17.247                                                                             1.00                                                                              19.78                                        ATOM  844                                                                               CG  PHE                                                                               171                                                                               53.874                                                                             1.411                                                                              16.018                                                                             1.00                                                                              17.53                                        ATOM  845                                                                               CD1 PHE                                                                               171                                                                               53.766                                                                             2.731                                                                              15.590                                                                             1.00                                                                              11.80                                        ATOM  846                                                                               CD2 PHE                                                                               171                                                                               53.148                                                                             0.422                                                                              15.330                                                                             1.00                                                                              14.77                                        ATOM  847                                                                               CE1 PHE                                                                               171                                                                               52.941                                                                             3.067                                                                              14.504                                                                             1.00                                                                              11.46                                        ATOM  848                                                                               CE2 PHE                                                                               171                                                                               52.315                                                                             0.758                                                                              14.242                                                                             1.00                                                                              10.44                                        ATOM  849                                                                               CZ  PHE                                                                               171                                                                               52.214                                                                             2.085                                                                              13.836                                                                             1.00                                                                              6.72                                         ATOM  850                                                                               C   PHE                                                                               171                                                                               52.659                                                                             0.183                                                                              18.471                                                                             1.00                                                                              21.88                                        ATOM  851                                                                               O   PHE                                                                               171                                                                               51.556                                                                             0.693                                                                              18.381                                                                             1.00                                                                              23.54                                        ATOM  852                                                                               N   SER                                                                               172                                                                               52.839                                                                             -1.129                                                                             18.540                                                                             1.00                                                                              23.14                                        ATOM  853                                                                               CA  SER                                                                               172                                                                               51.729                                                                             -2.069                                                                             18.428                                                                             1.00                                                                              27.99                                        ATOM  854                                                                               CB  SER                                                                               172                                                                               52.228                                                                             -3.504                                                                             18.485                                                                             1.00                                                                              27.59                                        ATOM  855                                                                               OG  SER                                                                               172                                                                               53.331                                                                             -3.669                                                                             17.624                                                                             1.00                                                                              31.04                                        ATOM  856                                                                               C   SER                                                                               172                                                                               50.751                                                                             -1.875                                                                             19.547                                                                             1.00                                                                              33.07                                        ATOM  857                                                                               O   SER                                                                               172                                                                               49.564                                                                             -2.166                                                                             19.392                                                                             1.00                                                                              38.22                                        ATOM  858                                                                               N   GLN                                                                               173                                                                               51.276                                                                             -1.425                                                                             20.684                                                                             1.00                                                                              36.24                                        ATOM  859                                                                               CA  GLN                                                                               173                                                                               50.509                                                                             -1.166                                                                             21.903                                                                             1.00                                                                              37.57                                        ATOM  860                                                                               CB  GLN                                                                               173                                                                               51.499                                                                             -0.888                                                                             23.068                                                                             1.00                                                                              44.34                                        ATOM  861                                                                               CG  GLN                                                                               173                                                                               50.894                                                                             -0.718                                                                             24.476                                                                             1.00                                                                              54.23                                        ATOM  862                                                                               CD  GLN                                                                               173                                                                               51.291                                                                             -1.831                                                                             25.447                                                                             1.00                                                                              60.34                                        ATOM  863                                                                               OE1 GLN                                                                               173                                                                               51.402                                                                             -1.609                                                                             26.659                                                                             1.00                                                                              57.52                                        ATOM  864                                                                               NE2 GLN                                                                               173                                                                               51.482                                                                             -3.040                                                                             24.921                                                                             1.00                                                                              66.46                                        ATOM  865                                                                               C   GLN                                                                               173                                                                               49.557                                                                             0.031                                                                              21.692                                                                             1.00                                                                              32.96                                        ATOM  866                                                                               O   GLN                                                                               173                                                                               48.324                                                                             -0.078                                                                             21.833                                                                             1.00                                                                              30.70                                        ATOM  867                                                                               N   ALA                                                                               174                                                                               50.142                                                                             1.166                                                                              21.342                                                                             1.00                                                                              25.13                                        ATOM  868                                                                               CA  ALA                                                                               174                                                                               49.371                                                                             2.356                                                                              21.124                                                                             1.00                                                                              23.49                                        ATOM  869                                                                               CB  ALA                                                                               174                                                                               50.288                                                                             3.499                                                                              20.814                                                                             1.00                                                                              20.35                                        ATOM  870                                                                               C   ALA                                                                               174                                                                               48.368                                                                             2.139                                                                              20.008                                                                             1.00                                                                              22.23                                        ATOM  871                                                                               O   ALA                                                                               174                                                                               47.176                                                                             2.342                                                                              20.208                                                                             1.00                                                                              28.71                                        ATOM  872                                                                               N   GLU                                                                               175                                                                               48.833                                                                             1.646                                                                              18.866                                                                             1.00                                                                              23.39                                        ATOM  873                                                                               CA  GLU                                                                               175                                                                               47.973                                                                             1.415                                                                              17.700                                                                             1.00                                                                              24.62                                        ATOM  874                                                                               CB  GLU                                                                               175                                                                               48.790                                                                             0.901                                                                              16.506                                                                             1.00                                                                              23.76                                        ATOM  875                                                                               CG  GLU                                                                               175                                                                               48.055                                                                             0.935                                                                              15.154                                                                             1.00                                                                              28.00                                        ATOM  876                                                                               CD  GLU                                                                               175                                                                               47.069                                                                             -0.208                                                                             14.953                                                                             1.00                                                                              24.81                                        ATOM  877                                                                               OE1 GLU                                                                               175                                                                               47.415                                                                             -1.356                                                                             15.249                                                                             1.00                                                                              30.25                                        ATOM  878                                                                               OE2 GLU                                                                               175                                                                               45.944                                                                             0.031                                                                              14.499                                                                             1.00                                                                              25.54                                        ATOM  879                                                                               C   GLU                                                                               175                                                                               46.815                                                                             0.465                                                                              17.975                                                                             1.00                                                                              23.05                                        ATOM  880                                                                               O   GLU                                                                               175                                                                               45.680                                                                             0.718                                                                              17.549                                                                             1.00                                                                              23.75                                        ATOM  881                                                                               N   SER                                                                               176                                                                               47.117                                                                             -0.658                                                                             18.610                                                                             1.00                                                                              23.70                                        ATOM  882                                                                               CA  SER                                                                               176                                                                               46.093                                                                             -1.633                                                                             18.939                                                                             1.00                                                                              25.29                                        ATOM  883                                                                               CB  SER                                                                               176                                                                               46.720                                                                             -2.904                                                                             19.483                                                                             1.00                                                                              27.82                                        ATOM  884                                                                               OG  SER                                                                               176                                                                               45.715                                                                             -3.746                                                                             20.007                                                                             1.00                                                                              37.64                                        ATOM  885                                                                               C   SER                                                                               176                                                                               45.113                                                                             -1.066                                                                             19.955                                                                             1.00                                                                              27.15                                        ATOM  886                                                                               O   SER                                                                               176                                                                               43.911                                                                             -1.266                                                                             19.827                                                                             1.00                                                                              29.62                                        ATOM  887                                                                               N   HIS                                                                               177                                                                               45.616                                                                             -0.343                                                                             20.953                                                                             1.00                                                                              27.84                                        ATOM  888                                                                               CA  HIS                                                                               177                                                                               44.736                                                                             0.231                                                                              21.947                                                                             1.00                                                                              29.40                                        ATOM  889                                                                               CB  HIS                                                                               177                                                                               45.525                                                                             0.880                                                                              23.083                                                                             1.00                                                                              35.05                                        ATOM  890                                                                               CG  HIS                                                                               177                                                                               44.670                                                                             1.358                                                                              24.221                                                                             1.00                                                                              39.71                                        ATOM  891                                                                               CD2 HIS                                                                               177                                                                               43.330                                                                             1.519                                                                              24.331                                                                             1.00                                                                              39.99                                        ATOM  892                                                                               ND1 HIS                                                                               177                                                                               45.195                                                                             1.730                                                                              25.442                                                                             1.00                                                                              45.29                                        ATOM  893                                                                               CE1 HIS                                                                               177                                                                               44.215                                                                             2.098                                                                              26.251                                                                             1.00                                                                              43.30                                        ATOM  894                                                                               NE2 HIS                                                                               177                                                                               43.072                                                                             1.979                                                                              25.598                                                                             1.00                                                                              41.68                                        ATOM  895                                                                               C   HIS                                                                               177                                                                               43.827                                                                             1.248                                                                              21.262                                                                             1.00                                                                              31.02                                        ATOM  896                                                                               O   HIS                                                                               177                                                                               42.624                                                                             1.300                                                                              21.534                                                                             1.00                                                                              35.22                                        ATOM  897                                                                               N   PHE                                                                               178                                                                               44.369                                                                             2.050                                                                              20.359                                                                             1.00                                                                              28.97                                        ATOM  898                                                                               CA  PHE                                                                               178                                                                               43.525                                                                             3.023                                                                              19.683                                                                             1.00                                                                              28.86                                        ATOM  899                                                                               CB  PHE                                                                               178                                                                               44.358                                                                             3.929                                                                              18.779                                                                             1.00                                                                              25.66                                        ATOM  900                                                                               CG  PHE                                                                               178                                                                               44.816                                                                             5.209                                                                              19.441                                                                             1.00                                                                              22.69                                        ATOM  901                                                                               CD1 PHE                                                                               178                                                                               46.085                                                                             5.312                                                                              19.993                                                                             1.00                                                                              25.93                                        ATOM  902                                                                               CD2 PHE                                                                               178                                                                               44.019                                                                             6.347                                                                              19.411                                                                             1.00                                                                              23.46                                        ATOM  903                                                                               CE1 PHE                                                                               178                                                                               46.560                                                                             6.537                                                                              20.490                                                                             1.00                                                                              20.31                                        ATOM  904                                                                               CE2 PHE                                                                               178                                                                               44.485                                                                             7.567                                                                              19.906                                                                             1.00                                                                              21.41                                        ATOM  905                                                                               CZ  PHE                                                                               178                                                                               45.757                                                                             7.654                                                                              20.439                                                                             1.00                                                                              21.04                                        ATOM  906                                                                               C   PHE                                                                               178                                                                               42.457                                                                             2.290                                                                              18.875                                                                             1.00                                                                              29.52                                        ATOM  907                                                                               O   PHE                                                                               178                                                                               41.268                                                                             2.545                                                                              19.022                                                                             1.00                                                                              25.37                                        ATOM  908                                                                               N   ARG                                                                               179                                                                               42.888                                                                             1.299                                                                              18.105                                                                             1.00                                                                              32.49                                        ATOM  909                                                                               CA  ARG                                                                               179                                                                               41.989                                                                             0.525                                                                              17.269                                                                             1.00                                                                              30.66                                        ATOM  910                                                                               CB  ARG                                                                               179                                                                               42.733                                                                             -0.654                                                                             16.646                                                                             1.00                                                                              31.64                                        ATOM  911                                                                               CG  ARG                                                                               179                                                                               41.976                                                                             -1.291                                                                             15.519                                                                             1.00                                                                              34.21                                        ATOM  912                                                                               CD  ARG                                                                               179                                                                               42.831                                                                             -2.263                                                                             14.759                                                                             1.00                                                                              41.71                                        ATOM  913                                                                               NE  ARG                                                                               179                                                                               42.897                                                                             -3.560                                                                             15.417                                                                             1.00                                                                              45.91                                        ATOM  914                                                                               CZ  ARG                                                                               179                                                                               44.010                                                                             -4.095                                                                             15.909                                                                             1.00                                                                              52.23                                        ATOM  915                                                                               NH1 ARG                                                                               179                                                                               45.166                                                                             -3.448                                                                             15.815                                                                             1.00                                                                              48.56                                        ATOM  916                                                                               NH2 ARG                                                                               179                                                                               43.961                                                                             -5.278                                                                             16.518                                                                             1.00                                                                              60.56                                        ATOM  917                                                                               C   ARG                                                                               179                                                                               40.780                                                                             0.018                                                                              18.026                                                                             1.00                                                                              29.30                                        ATOM  918                                                                               O   ARG                                                                               179                                                                               39.656                                                                             0.169                                                                              17.574                                                                             1.00                                                                              34.87                                        ATOM  919                                                                               N   ASN                                                                               180                                                                               41.004                                                                             -0.537                                                                             19.201                                                                             1.00                                                                              29.94                                        ATOM  920                                                                               CA  ASN                                                                               180                                                                               39.911                                                                             -1.077                                                                             19.992                                                                             1.00                                                                              32.10                                        ATOM  921                                                                               CB  ASN                                                                               180                                                                               40.418                                                                             -2.277                                                                             20.804                                                                             1.00                                                                              36.87                                        ATOM  922                                                                               CG  ASN                                                                               180                                                                               41.000                                                                             -3.393                                                                             19.917                                                                             1.00                                                                              38.96                                        ATOM  923                                                                               OD1 ASN                                                                               180                                                                               40.358                                                                             -3.861                                                                             18.981                                                                             1.00                                                                              40.44                                        ATOM  924                                                                               ND2 ASN                                                                               180                                                                               42.214                                                                             -3.821                                                                             20.224                                                                             1.00                                                                              42.74                                        ATOM  925                                                                               C   ASN                                                                               180                                                                               39.125                                                                             -0.073                                                                             20.875                                                                             1.00                                                                              32.03                                        ATOM  926                                                                               O   ASN                                                                               180                                                                               38.036                                                                             -0.387                                                                             21.337                                                                             1.00                                                                              34.18                                        ATOM  927                                                                               N   SER                                                                               181                                                                               39.661                                                                             1.126                                                                              21.106                                                                             1.00                                                                              32.59                                        ATOM  928                                                                               CA  SER                                                                               181                                                                               38.965                                                                             2.150                                                                              21.904                                                                             1.00                                                                              26.92                                        ATOM  929                                                                               CB  SER                                                                               181                                                                               39.939                                                                             3.211                                                                              22.429                                                                             1.00                                                                              27.48                                        ATOM  930                                                                               OG  SER                                                                               181                                                                               40.884                                                                             2.658                                                                              23.324                                                                             1.00                                                                              31.01                                        ATOM  931                                                                               C   SER                                                                               181                                                                               37.883                                                                             2.902                                                                              21.134                                                                             1.00                                                                              25.45                                        ATOM  932                                                                               O   SER                                                                               181                                                                               36.871                                                                             3.288                                                                              21.705                                                                             1.00                                                                              25.81                                        ATOM  933                                                                               N   MET                                                                               182                                                                               38.111                                                                             3.143                                                                              19.847                                                                             1.00                                                                              23.99                                        ATOM  934                                                                               CA  MET                                                                               182                                                                               37.169                                                                             3.898                                                                              19.014                                                                             1.00                                                                              24.66                                        ATOM  935                                                                               CB  MET                                                                               182                                                                               37.418                                                                             3.676                                                                              17.519                                                                             1.00                                                                              25.35                                        ATOM  936                                                                               CG  MET                                                                               182                                                                               38.588                                                                             4.436                                                                              16.936                                                                             1.00                                                                              22.11                                        ATOM  937                                                                               SD  MET                                                                               182                                                                               38.582                                                                             6.169                                                                              17.397                                                                             1.00                                                                              31.27                                        ATOM  938                                                                               CE  MET                                                                               182                                                                               40.288                                                                             6.254                                                                              17.748                                                                             1.00                                                                              28.60                                        ATOM  939                                                                               C   MET                                                                               182                                                                               35.697                                                                             3.699                                                                              19.298                                                                             1.00                                                                              22.86                                        ATOM  940                                                                               O   MET                                                                               182                                                                               34.946                                                                             4.674                                                                              19.354                                                                             1.00                                                                              26.55                                        ATOM  941                                                                               N   PRO                                                                               183                                                                               35.257                                                                             2.448                                                                              19.504                                                                             1.00                                                                              20.02                                        ATOM  942                                                                               CD  PRO                                                                               183                                                                               35.911                                                                             1.131                                                                              19.367                                                                             1.00                                                                              17.72                                        ATOM  943                                                                               CA  PRO                                                                               183                                                                               33.814                                                                             2.311                                                                              19.771                                                                             1.00                                                                              20.18                                        ATOM  944                                                                               CB  PRO                                                                               183                                                                               33.626                                                                             0.790                                                                              19.918                                                                             1.00                                                                              19.03                                        ATOM  945                                                                               CG  PRO                                                                               183                                                                               34.758                                                                             0.210                                                                              19.057                                                                             1.00                                                                              15.96                                        ATOM  946                                                                               C   PRO                                                                               183                                                                               33.306                                                                             3.109                                                                              20.990                                                                             1.00                                                                              21.68                                        ATOM  947                                                                               O   PRO                                                                               183                                                                               32.167                                                                             3.557                                                                              20.995                                                                             1.00                                                                              27.17                                        ATOM  948                                                                               N   SER                                                                               184                                                                               34.166                                                                             3.342                                                                              21.986                                                                             1.00                                                                              22.98                                        ATOM  949                                                                               CA  SER                                                                               184                                                                               33.813                                                                             4.107                                                                              23.186                                                                             1.00                                                                              18.39                                        ATOM  950                                                                               CB  SER                                                                               184                                                                               34.968                                                                             4.066                                                                              24.198                                                                             1.00                                                                              15.92                                        ATOM  951                                                                               OG  SER                                                                               184                                                                               35.328                                                                             2.729                                                                              24.522                                                                             1.00                                                                              15.22                                        ATOM  952                                                                               C   SER                                                                               184                                                                               33.432                                                                             5.568                                                                              22.895                                                                             1.00                                                                              21.41                                        ATOM  953                                                                               O   SER                                                                               184                                                                               32.924                                                                             6.254                                                                              23.776                                                                             1.00                                                                              17.59                                        ATOM  954                                                                               N   PHE                                                                               185                                                                               33.702                                                                             6.057                                                                              21.682                                                                             1.00                                                                              20.87                                        ATOM  955                                                                               CA  PHE                                                                               185                                                                               33.367                                                                             7.435                                                                              21.342                                                                             1.00                                                                              21.72                                        ATOM  956                                                                               CB  PHE                                                                               185                                                                               34.591                                                                             8.195                                                                              20.843                                                                             1.00                                                                              19.91                                        ATOM  957                                                                               CG  PHE                                                                               185                                                                               35.865                                                                             7.857                                                                              21.578                                                                             1.00                                                                              23.10                                        ATOM  958                                                                               CD1 PHE                                                                               185                                                                               37.033                                                                             7.561                                                                              20.875                                                                             1.00                                                                              20.78                                        ATOM  959                                                                               CD2 PHE                                                                               185                                                                               35.909                                                                             7.840                                                                              22.960                                                                             1.00                                                                              19.79                                        ATOM  960                                                                               CE1 PHE                                                                               185                                                                               38.226                                                                             7.252                                                                              21.546                                                                             1.00                                                                              23.07                                        ATOM  961                                                                               CE2 PHE                                                                               185                                                                               37.106                                                                             7.529                                                                              23.633                                                                             1.00                                                                              25.58                                        ATOM  962                                                                               CZ  PHE                                                                               185                                                                               38.262                                                                             7.235                                                                              22.920                                                                             1.00                                                                              16.31                                        ATOM  963                                                                               C   PHE                                                                               185                                                                               32.306                                                                             7.429                                                                              20.261                                                                             1.00                                                                              24.33                                        ATOM  964                                                                               O   PHE                                                                               185                                                                               32.075                                                                             8.432                                                                              19.599                                                                             1.00                                                                              24.66                                        ATOM  965                                                                               N   ALA                                                                               186                                                                               31.613                                                                             6.306                                                                              20.134                                                                             1.00                                                                              28.12                                        ATOM  966                                                                               CA  ALA                                                                               186                                                                               30.581                                                                             6.146                                                                              19.116                                                                             1.00                                                                              27.05                                        ATOM  967                                                                               CB  ALA                                                                               186                                                                               31.189                                                                             5.473                                                                              17.870                                                                             1.00                                                                              29.72                                        ATOM  968                                                                               C   ALA                                                                               186                                                                               29.469                                                                             5.283                                                                              19.684                                                                             1.00                                                                              26.76                                        ATOM  969                                                                               O   ALA                                                                               186                                                                               28.840                                                                             4.492                                                                              18.969                                                                             1.00                                                                              26.03                                        ATOM  970                                                                               N   VAL                                                                               187                                                                               29.265                                                                             5.415                                                                              20.986                                                                             1.00                                                                              27.16                                        ATOM  971                                                                               CA  VAL                                                                               187                                                                               28.238                                                                             4.661                                                                              21.689                                                                             1.00                                                                              29.69                                        ATOM  972                                                                               CB  VAL                                                                               187                                                                               28.175                                                                             5.047                                                                              23.170                                                                             1.00                                                                              29.53                                        ATOM  973                                                                               CG1 VAL                                                                               187                                                                               27.451                                                                             3.986                                                                              23.923                                                                             1.00                                                                              32.69                                        ATOM  974                                                                               CG2 VAL                                                                               187                                                                               29.555                                                                             5.282                                                                              23.730                                                                             1.00                                                                              31.55                                        ATOM  975                                                                               C   VAL                                                                               187                                                                               26.867                                                                             4.963                                                                              21.092                                                                             1.00                                                                              30.99                                        ATOM  976                                                                               O   VAL                                                                               187                                                                               26.544                                                                             6.121                                                                              20.818                                                                             1.00                                                                              32.51                                        ATOM  977                                                                               N   SER                                                                               188                                                                               26.045                                                                             3.933                                                                              20.944                                                                             1.00                                                                              33.95                                        ATOM  978                                                                               CA  SER                                                                               188                                                                               24.703                                                                             4.094                                                                              20.392                                                                             1.00                                                                              39.13                                        ATOM  979                                                                               CB  SER                                                                               188                                                                               23.924                                                                             2.782                                                                              20.524                                                                             1.00                                                                              37.12                                        ATOM  980                                                                               OG  SER                                                                               188                                                                               23.056                                                                             2.573                                                                              19.415                                                                             1.00                                                                              42.00                                        ATOM  981                                                                               C   SER                                                                               188                                                                               23.960                                                                             5.228                                                                              21.104                                                                             1.00                                                                              40.12                                        ATOM  982                                                                               O   SER                                                                               188                                                                               24.106                                                                             5.401                                                                              22.316                                                                             1.00                                                                              42.73                                        ATOM  983                                                                               N   LYS                                                                               189                                                                               23.231                                                                             6.038                                                                              20.338                                                                             1.00                                                                              42.68                                        ATOM  984                                                                               CA  LYS                                                                               189                                                                               22.468                                                                             7.158                                                                              20.883                                                                             1.00                                                                              43.93                                        ATOM  985                                                                               CB  LYS                                                                               189                                                                               21.718                                                                             6.715                                                                              22.151                                                                             1.00                                                                              51.42                                        ATOM  986                                                                               CG  LYS                                                                               189                                                                               20.770                                                                             7.737                                                                              22.743                                                                             1.00                                                                              65.46                                        ATOM  987                                                                               CD  LYS                                                                               189                                                                               20.195                                                                             7.249                                                                              24.074                                                                             1.00                                                                              75.80                                        ATOM  988                                                                               CE  LYS                                                                               189                                                                               19.366                                                                             8.343                                                                              24.769                                                                             1.00                                                                              83.02                                        ATOM  989                                                                               NZ  LYS                                                                               189                                                                               18.929                                                                             7.964                                                                              26.159                                                                             1.00                                                                              86.33                                        ATOM  990                                                                               C   LYS                                                                               189                                                                               23.322                                                                             8.395                                                                              21.177                                                                             1.00                                                                              39.73                                        ATOM  991                                                                               O   LYS                                                                               189                                                                               22.799                                                                             9.507                                                                              21.251                                                                             1.00                                                                              40.92                                        ATOM  992                                                                               N   PHE                                                                               190                                                                               24.633                                                                             8.220                                                                              21.297                                                                             1.00                                                                              36.45                                        ATOM  993                                                                               CA  PHE                                                                               190                                                                               25.532                                                                             9.339                                                                              21.596                                                                             1.00                                                                              32.97                                        ATOM  994                                                                               CB  PHE                                                                               190                                                                               26.266                                                                             9.053                                                                              22.906                                                                             1.00                                                                              35.66                                        ATOM  995                                                                               CG  PHE                                                                               190                                                                               25.349                                                                             8.799                                                                              24.059                                                                             1.00                                                                              37.16                                        ATOM  996                                                                               CD1 PHE                                                                               190                                                                               25.169                                                                             7.510                                                                              24.544                                                                             1.00                                                                              37.15                                        ATOM  997                                                                               CD2 PHE                                                                               190                                                                               24.620                                                                             9.841                                                                              24.623                                                                             1.00                                                                              37.31                                        ATOM  998                                                                               CE1 PHE                                                                               190                                                                               24.279                                                                             7.259                                                                              25.568                                                                             1.00                                                                              36.95                                        ATOM  999                                                                               CE2 PHE                                                                               190                                                                               23.722                                                                             9.602                                                                              25.652                                                                             1.00                                                                              37.94                                        ATOM  1000                                                                              CZ  PHE                                                                               190                                                                               23.551                                                                             8.310                                                                              26.124                                                                             1.00                                                                              37.75                                        ATOM  1001                                                                              C   PHE                                                                               190                                                                               26.554                                                                             9.640                                                                              20.499                                                                             1.00                                                                              28.22                                        ATOM  1002                                                                              O   PHE                                                                               190                                                                               27.573                                                                             10.285                                                                             20.746                                                                             1.00                                                                              27.75                                        ATOM  1003                                                                              N   GLU                                                                               191                                                                               26.270                                                                             9.210                                                                              19.280                                                                             1.00                                                                              27.87                                        ATOM  1004                                                                              CA  GLU                                                                               191                                                                               27.212                                                                             9.420                                                                              18.196                                                                             1.00                                                                              25.18                                        ATOM  1005                                                                              CB  GLU                                                                               191                                                                               26.823                                                                             8.642                                                                              16.961                                                                             1.00                                                                              23.69                                        ATOM  1006                                                                              CG  GLU                                                                               191                                                                               26.809                                                                             7.147                                                                              17.187                                                                             1.00                                                                              25.09                                        ATOM  1007                                                                              CD  GLU                                                                               191                                                                               25.416                                                                             6.613                                                                              17.376                                                                             1.00                                                                              26.96                                        ATOM  1008                                                                              OE1 GLU                                                                               191                                                                               25.157                                                                             5.496                                                                              16.884                                                                             1.00                                                                              31.29                                        ATOM  1009                                                                              OE2 GLU                                                                               191                                                                               24.575                                                                             7.304                                                                              18.090                                                                             1.00                                                                              27.39                                        ATOM  1010                                                                              C   GLU                                                                               191                                                                               27.439                                                                             10.865                                                                             17.869                                                                             1.00                                                                              25.02                                        ATOM  1011                                                                              O   GLU                                                                               191                                                                               28.576                                                                             11.247                                                                             17.631                                                                             1.00                                                                              27.85                                        ATOM  1012                                                                              N   VAL                                                                               192                                                                               26.391                                                                             11.686                                                                             17.898                                                                             1.00                                                                              27.84                                        ATOM  1013                                                                              CA  VAL                                                                               192                                                                               26.557                                                                             13.114                                                                             17.620                                                                             1.00                                                                              25.95                                        ATOM  1014                                                                              CB  VAL                                                                               192                                                                               25.232                                                                             13.804                                                                             17.352                                                                             1.00                                                                              26.44                                        ATOM  1015                                                                              CG1 VAL                                                                               192                                                                               25.468                                                                             15.283                                                                             17.037                                                                             1.00                                                                              24.26                                        ATOM  1016                                                                              CG2 VAL                                                                               192                                                                               24.489                                                                             13.089                                                                             16.240                                                                             1.00                                                                              22.90                                        ATOM  1017                                                                              C   VAL                                                                               192                                                                               27.245                                                                             13.824                                                                             18.793                                                                             1.00                                                                              28.20                                        ATOM  1018                                                                              O   VAL                                                                               192                                                                               28.198                                                                             14.584                                                                             18.605                                                                             1.00                                                                              33.10                                        ATOM  1019                                                                              N   LEU                                                                               193                                                                               26.805                                                                             13.541                                                                             20.010                                                                             1.00                                                                              24.52                                        ATOM  1020                                                                              CA  LEU                                                                               193                                                                               27.408                                                                             14.174                                                                             21.178                                                                             1.00                                                                              25.78                                        ATOM  1021                                                                              CB  LEU                                                                               193                                                                               26.669                                                                             13.706                                                                             22.436                                                                             1.00                                                                              25.22                                        ATOM  1022                                                                              CG  LEU                                                                               193                                                                               25.241                                                                             14.207                                                                             22.612                                                                             1.00                                                                              17.24                                        ATOM  1023                                                                              CD1 LEU                                                                               193                                                                               24.489                                                                             13.345                                                                             23.599                                                                             1.00                                                                              24.15                                        ATOM  1024                                                                              CD2 LEU                                                                               193                                                                               25.303                                                                             15.634                                                                             23.111                                                                             1.00                                                                              22.79                                        ATOM  1025                                                                              C   LEU                                                                               193                                                                               28.936                                                                             13.937                                                                             21.316                                                                             1.00                                                                              27.53                                        ATOM  1026                                                                              O   LEU                                                                               193                                                                               29.675                                                                             14.798                                                                             21.835                                                                             1.00                                                                              22.52                                        ATOM  1027                                                                              N   PHE                                                                               194                                                                               29.394                                                                             12.767                                                                             20.860                                                                             1.00                                                                              28.95                                        ATOM  1028                                                                              CA  PHE                                                                               194                                                                               30.809                                                                             12.371                                                                             20.912                                                                             1.00                                                                              27.24                                        ATOM  1029                                                                              CB  PHE                                                                               194                                                                               30.926                                                                             10.838                                                                             21.023                                                                             1.00                                                                              23.99                                        ATOM  1030                                                                              CG  PHE                                                                               194                                                                               30.883                                                                             10.302                                                                             22.424                                                                             1.00                                                                              19.23                                        ATOM  1031                                                                              CD1 PHE                                                                               194                                                                               29.946                                                                             9.331                                                                              22.771                                                                             1.00                                                                              16.74                                        ATOM  1032                                                                              CD2 PHE                                                                               194                                                                               31.806                                                                             10.734                                                                             23.381                                                                             1.00                                                                              12.01                                        ATOM  1033                                                                              CE1 PHE                                                                               194                                                                               29.924                                                                             8.790                                                                              24.058                                                                             1.00                                                                              20.23                                        ATOM  1034                                                                              CE2 PHE                                                                               194                                                                               31.807                                                                             10.213                                                                             24.670                                                                             1.00                                                                              15.47                                        ATOM  1035                                                                              CZ  PHE                                                                               194                                                                               30.862                                                                             9.233                                                                              25.019                                                                             1.00                                                                              21.85                                        ATOM  1036                                                                              C   PHE                                                                               194                                                                               31.597                                                                             12.769                                                                             19.653                                                                             1.00                                                                              30.35                                        ATOM  1037                                                                              O   PHE                                                                               194                                                                               32.771                                                                             12.413                                                                             19.540                                                                             1.00                                                                              33.71                                        ATOM  1038                                                                              N   LEU                                                                               195                                                                               30.990                                                                             13.512                                                                             18.730                                                                             1.00                                                                              27.41                                        ATOM  1039                                                                              CA  LEU                                                                               195                                                                               31.659                                                                             13.845                                                                             17.466                                                                             1.00                                                                              23.44                                        ATOM  1040                                                                              CB  LEU                                                                               195                                                                               30.755                                                                             14.704                                                                             16.592                                                                             1.00                                                                              24.37                                        ATOM  1041                                                                              CG  LEU                                                                               195                                                                               30.899                                                                             14.393                                                                             15.109                                                                             1.00                                                                              30.12                                        ATOM  1042                                                                              CD1 LEU                                                                               195                                                                               30.651                                                                             12.891                                                                             14.842                                                                             1.00                                                                              26.11                                        ATOM  1043                                                                              CD2 LEU                                                                               195                                                                               29.922                                                                             15.244                                                                             14.338                                                                             1.00                                                                              30.52                                        ATOM  1044                                                                              C   LEU                                                                               195                                                                               33.074                                                                             14.407                                                                             17.465                                                                             1.00                                                                              18.68                                        ATOM  1045                                                                              O   LEU                                                                               195                                                                               33.954                                                                             13.869                                                                             16.809                                                                             1.00                                                                              20.43                                        ATOM  1046                                                                              N   PRO                                                                               196                                                                               33.316                                                                             15.503                                                                             18.173                                                                             1.00                                                                              16.00                                        ATOM  1047                                                                              CD  PRO                                                                               196                                                                               32.351                                                                             16.380                                                                             18.850                                                                             1.00                                                                              13.80                                        ATOM  1048                                                                              CA  PRO                                                                               196                                                                               34.668                                                                             16.072                                                                             18.193                                                                             1.00                                                                              14.01                                        ATOM  1049                                                                              CB  PRO                                                                               196                                                                               34.491                                                                             17.343                                                                             18.993                                                                             1.00                                                                              14.53                                        ATOM  1050                                                                              CG  PRO                                                                               196                                                                               33.026                                                                             17.698                                                                             18.756                                                                             1.00                                                                              16.77                                        ATOM  1051                                                                              C   PRO                                                                               196                                                                               35.683                                                                             15.150                                                                             18.848                                                                             1.00                                                                              17.13                                        ATOM  1052                                                                              O   PRO                                                                               196                                                                               36.828                                                                             15.048                                                                             18.395                                                                             1.00                                                                              19.94                                        ATOM  1053                                                                              N   THR                                                                               197                                                                               35.268                                                                             14.499                                                                             19.929                                                                             1.00                                                                              18.61                                        ATOM  1054                                                                              CA  THR                                                                               197                                                                               36.118                                                                             13.557                                                                             20.659                                                                             1.00                                                                              20.79                                        ATOM  1055                                                                              CB  THR                                                                               197                                                                               35.320                                                                             12.890                                                                             21.797                                                                             1.00                                                                              24.29                                        ATOM  1056                                                                              OG1 THR                                                                               197                                                                               34.828                                                                             13.892                                                                             22.688                                                                             1.00                                                                              26.50                                        ATOM  1057                                                                              CG2 THR                                                                               197                                                                               36.182                                                                             11.905                                                                             22.554                                                                             1.00                                                                              20.17                                        ATOM  1058                                                                              C   THR                                                                               197                                                                               36.588                                                                             12.453                                                                             19.699                                                                             1.00                                                                              23.61                                        ATOM  1059                                                                              O   THR                                                                               197                                                                               37.780                                                                             12.111                                                                             19.663                                                                             1.00                                                                              26.22                                        ATOM  1060                                                                              N   TYR                                                                               198                                                                               35.631                                                                             11.891                                                                             18.946                                                                             1.00                                                                              21.68                                        ATOM  1061                                                                              CA  TYR                                                                               198                                                                               35.870                                                                             10.837                                                                             17.953                                                                             1.00                                                                              15.60                                        ATOM  1062                                                                              CB  TYR                                                                               198                                                                               34.545                                                                             10.373                                                                             17.342                                                                             1.00                                                                              12.95                                        ATOM  1063                                                                              CG  TYR                                                                               198                                                                               34.661                                                                             9.276                                                                              16.294                                                                             1.00                                                                              18.00                                        ATOM  1064                                                                              CD1 TYR                                                                               198                                                                               34.391                                                                             7.946                                                                              16.613                                                                             1.00                                                                              14.34                                        ATOM  1065                                                                              CE1 TYR                                                                               198                                                                               34.482                                                                             6.948                                                                              15.659                                                                             1.00                                                                              21.67                                        ATOM  1066                                                                              CD2 TYR                                                                               198                                                                               35.029                                                                             9.569                                                                              14.975                                                                             1.00                                                                              20.14                                        ATOM  1067                                                                              CE2 TYR                                                                               198                                                                               35.121                                                                             8.564                                                                              14.010                                                                             1.00                                                                              20.73                                        ATOM  1068                                                                              CZ  TYR                                                                               198                                                                               34.848                                                                             7.268                                                                              14.360                                                                             1.00                                                                              18.41                                        ATOM  1069                                                                              OH  TYR                                                                               198                                                                               34.917                                                                             6.287                                                                              13.407                                                                             1.00                                                                              24.92                                        ATOM  1070                                                                              C   TYR                                                                               198                                                                               36.807                                                                             11.342                                                                             16.850                                                                             1.00                                                                              19.32                                        ATOM  1071                                                                              O   TYR                                                                               198                                                                               37.813                                                                             10.700                                                                             16.554                                                                             1.00                                                                              19.54                                        ATOM  1072                                                                              N   ALA                                                                               199                                                                               36.494                                                                             12.487                                                                             16.251                                                                             1.00                                                                              14.36                                        ATOM  1073                                                                              CA  ALA                                                                               199                                                                               37.342                                                                             13.020                                                                             15.205                                                                             1.00                                                                              14.32                                        ATOM  1074                                                                              CB  ALA                                                                               199                                                                               36.818                                                                             14.357                                                                             14.748                                                                             1.00                                                                              16.43                                        ATOM  1075                                                                              C   ALA                                                                               199                                                                               38.789                                                                             13.146                                                                             15.694                                                                             1.00                                                                              16.89                                        ATOM  1076                                                                              O   ALA                                                                               199                                                                               39.714                                                                             12.639                                                                             15.044                                                                             1.00                                                                              16.56                                        ATOM  1077                                                                              N   GLN                                                                               200                                                                               38.964                                                                             13.765                                                                             16.868                                                                             1.00                                                                              18.58                                        ATOM  1078                                                                              CA  GLN                                                                               200                                                                               40.281                                                                             13.984                                                                             17.492                                                                             1.00                                                                              18.04                                        ATOM  1079                                                                              CB  GLN                                                                               200                                                                               40.151                                                                             14.844                                                                             18.744                                                                             1.00                                                                              16.98                                        ATOM  1080                                                                              CG  GLN                                                                               200                                                                               39.629                                                                             16.239                                                                             18.489                                                                             1.00                                                                              16.64                                        ATOM  1081                                                                              CD  GLN                                                                               200                                                                               40.593                                                                             17.109                                                                             17.709                                                                             1.00                                                                              17.76                                        ATOM  1082                                                                              CE1 GLN                                                                               200                                                                               41.811                                                                             16.965                                                                             17.821                                                                             1.00                                                                              20.73                                        ATOM  1083                                                                              NE2 GLN                                                                               200                                                                               40.051                                                                             18.032                                                                             16.926                                                                             1.00                                                                              16.40                                        ATOM  1084                                                                              C   GLN                                                                               200                                                                               41.067                                                                             12.721                                                                             17.833                                                                             1.00                                                                              16.13                                        ATOM  1085                                                                              O   GLN                                                                               200                                                                               42.287                                                                             12.732                                                                             17.758                                                                             1.00                                                                              18.50                                        ATOM  1086                                                                              N   ALA                                                                               201                                                                               40.393                                                                             11.665                                                                             18.276                                                                             1.00                                                                              15.14                                        ATOM  1087                                                                              CA  ALA                                                                               201                                                                               41.093                                                                             10.414                                                                             18.578                                                                             1.00                                                                              15.80                                        ATOM  1088                                                                              CB  ALA                                                                               201                                                                               40.244                                                                             9.507                                                                              19.463                                                                             1.00                                                                              11.71                                        ATOM  1089                                                                              C   ALA                                                                               201                                                                               41.447                                                                             9.696                                                                              17.277                                                                             1.00                                                                              15.73                                        ATOM  1090                                                                              O   ALA                                                                               201                                                                               42.521                                                                             9.110                                                                              17.155                                                                             1.00                                                                              23.19                                        ATOM  1091                                                                              N   ALA                                                                               202                                                                               40.528                                                                             9.724                                                                              16.315                                                                             1.00                                                                              16.63                                        ATOM  1092                                                                              CA  ALA                                                                               202                                                                               40.714                                                                             9.105                                                                              15.007                                                                             1.00                                                                              10.64                                        ATOM  1093                                                                              CB  ALA                                                                               202                                                                               39.519                                                                             9.386                                                                              14.120                                                                             1.00                                                                              12.27                                        ATOM  1094                                                                              C   ALA                                                                               202                                                                               41.954                                                                             9.686                                                                              14.376                                                                             1.00                                                                              11.25                                        ATOM  1095                                                                              O   ALA                                                                               202                                                                               42.855                                                                             8.966                                                                              13.963                                                                             1.00                                                                              12.02                                        ATOM  1096                                                                              N   ASN                                                                               203                                                                               42.005                                                                             11.005                                                                             14.328                                                                             1.00                                                                              10.25                                        ATOM  1097                                                                              CA  ASN                                                                               203                                                                               43.143                                                                             11.684                                                                             13.767                                                                             1.00                                                                              14.32                                        ATOM  1098                                                                              CB  ASN                                                                               203                                                                               43.015                                                                             13.167                                                                             14.008                                                                             1.00                                                                              14.52                                        ATOM  1099                                                                              CG  ASN                                                                               203                                                                               44.207                                                                             13.926                                                                             13.501                                                                             1.00                                                                              15.52                                        ATOM  1100                                                                              OD1 ASN                                                                               203                                                                               44.459                                                                             13.939                                                                             12.310                                                                             1.00                                                                              23.18                                        ATOM  1101                                                                              ND2 ASN                                                                               203                                                                               44.934                                                                             14.566                                                                             14.390                                                                             1.00                                                                              12.62                                        ATOM  1102                                                                              C   ASN                                                                               203                                                                               44.473                                                                             11.205                                                                             14.338                                                                             1.00                                                                              19.00                                        ATOM  1103                                                                              O   ASN                                                                               203                                                                               45.457                                                                             11.116                                                                             13.613                                                                             1.00                                                                              27.47                                        ATOM  1104                                                                              N   THR                                                                               204                                                                               44.518                                                                             10.882                                                                             15.628                                                                             1.00                                                                              19.90                                        ATOM  1105                                                                              CA  THR                                                                               204                                                                               45.765                                                                             10.433                                                                             16.249                                                                             1.00                                                                              19.76                                        ATOM  1106                                                                              CB  THR                                                                               204                                                                               45.691                                                                             10.527                                                                             17.761                                                                             1.00                                                                              19.43                                        ATOM  1107                                                                              OG1 THR                                                                               204                                                                               45.409                                                                             11.882                                                                             18.129                                                                             1.00                                                                              23.03                                        ATOM  1108                                                                              CG2 THR                                                                               204                                                                               47.001                                                                             10.115                                                                             18.364                                                                             1.00                                                                              22.47                                        ATOM  1109                                                                              C   THR                                                                               204                                                                               46.119                                                                             9.008                                                                              15.851                                                                             1.00                                                                              20.39                                        ATOM  1110                                                                              O   THR                                                                               204                                                                               47.300                                                                             8.673                                                                              15.663                                                                             1.00                                                                              11.64                                        ATOM  1111                                                                              N   HIS                                                                               205                                                                               45.079                                                                             8.179                                                                              15.718                                                                             1.00                                                                              15.29                                        ATOM  1112                                                                              CA  HIS                                                                               205                                                                               45.246                                                                             6.793                                                                              15.329                                                                             1.00                                                                              12.93                                        ATOM  1113                                                                              CB  HIS                                                                               205                                                                               43.890                                                                             6.119                                                                              15.300                                                                             1.00                                                                              9.41                                         ATOM  1114                                                                              CG  HIS                                                                               205                                                                               43.960                                                                             4.648                                                                              15.077                                                                             1.00                                                                              11.32                                        ATOM  1115                                                                              CD2 HIS                                                                               205                                                                               45.012                                                                             3.796                                                                              15.056                                                                             1.00                                                                              12.67                                        ATOM  1116                                                                              ND1 HIS                                                                               205                                                                               42.842                                                                             3.881                                                                              14.841                                                                             1.00                                                                              11.26                                        ATOM  1117                                                                              CE1 HIS                                                                               205                                                                               43.198                                                                             2.616                                                                              14.686                                                                             1.00                                                                              11.39                                        ATOM  1118                                                                              NE2 HIS                                                                               205                                                                               44.509                                                                             2.536                                                                              14.810                                                                             1.00                                                                              10.23                                        ATOM  1119                                                                              C   HIS                                                                               205                                                                               45.914                                                                             6.731                                                                              13.954                                                                             1.00                                                                              14.03                                        ATOM  1120                                                                              O   HIS                                                                               205                                                                               46.788                                                                             5.912                                                                              13.711                                                                             1.00                                                                              17.30                                        ATOM  1121                                                                              N   LEU                                                                               206                                                                               45.471                                                                             7.605                                                                              13.063                                                                             1.00                                                                              17.93                                        ATOM  1122                                                                              CA  LEU                                                                               206                                                                               45.988                                                                             7.716                                                                              11.705                                                                             1.00                                                                              20.38                                        ATOM  1123                                                                              CB  LEU                                                                               206                                                                               45.030                                                                             8.552                                                                              10.837                                                                             1.00                                                                              15.00                                        ATOM  1124                                                                              CG  LEU                                                                               206                                                                               43.611                                                                             7.985                                                                              10.669                                                                             1.00                                                                              17.79                                        ATOM  1125                                                                              CD1 LEU                                                                               206                                                                               42.902                                                                             8.815                                                                              9.643                                                                              1.00                                                                              16.39                                        ATOM  1126                                                                              CD2 LEU                                                                               206                                                                               43.606                                                                             6.519                                                                              10.256                                                                             1.00                                                                              7.72                                         ATOM  1127                                                                              C   LEU                                                                               206                                                                               47.394                                                                             8.333                                                                              11.670                                                                             1.00                                                                              22.16                                        ATOM  1128                                                                              O   LEU                                                                               206                                                                               48.260                                                                             7.964                                                                              10.811                                                                             1.00                                                                              26.75                                        ATOM  1129                                                                              N   LEU                                                                               207                                                                               47.652                                                                             9.315                                                                              12.541                                                                             1.00                                                                              18.99                                        ATOM  1130                                                                              CA  LEU                                                                               207                                                                               48.959                                                                             9.965                                                                              12.637                                                                             1.00                                                                              17.75                                        ATOM  1131                                                                              CB  LEU                                                                               207                                                                               48.953                                                                             11.016                                                                             13.716                                                                             1.00                                                                              18.85                                        ATOM  1132                                                                              CG  LEU                                                                               207                                                                               48.829                                                                             12.451                                                                             13.261                                                                             1.00                                                                              26.70                                        ATOM  1133                                                                              CD1 LEU                                                                               207                                                                               48.941                                                                             13.280                                                                             14.541                                                                             1.00                                                                              20.06                                        ATOM  1134                                                                              CD2 LEU                                                                               207                                                                               49.924                                                                             12.829                                                                             12.198                                                                             1.00                                                                              20.90                                        ATOM  1135                                                                              C   LEU                                                                               207                                                                               49.982                                                                             8.960                                                                              13.077                                                                             1.00                                                                              19.69                                        ATOM  1136                                                                              O   LEU                                                                               207                                                                               51.156                                                                             9.075                                                                              12.767                                                                             1.00                                                                              25.73                                        ATOM  1137                                                                              N   LEU                                                                               208                                                                               49.534                                                                             8.035                                                                              13.901                                                                             1.00                                                                              20.55                                        ATOM  1138                                                                              CA  LEU                                                                               208                                                                               50.377                                                                             6.989                                                                              14.433                                                                             1.00                                                                              21.59                                        ATOM  1139                                                                              CB  LEU                                                                               208                                                                               49.719                                                                             6.449                                                                              15.683                                                                             1.00                                                                              22.51                                        ATOM  1140                                                                              CG  LEU                                                                               208                                                                               50.338                                                                             5.240                                                                              16.322                                                                             1.00                                                                              25.67                                        ATOM  1141                                                                              CD1 LEU                                                                               208                                                                               51.707                                                                             5.621                                                                              16.833                                                                             1.00                                                                              25.95                                        ATOM  1142                                                                              CD2 LEU                                                                               208                                                                               49.403                                                                             4.792                                                                              17.428                                                                             1.00                                                                              24.34                                        ATOM  1143                                                                              C   LEU                                                                               208                                                                               50.607                                                                             5.874                                                                              13.411                                                                             1.00                                                                              21.91                                        ATOM  1144                                                                              O   LEU                                                                               208                                                                               51.758                                                                             5.505                                                                              13.173                                                                             1.00                                                                              25.74                                        ATOM  1145                                                                              N   LEU                                                                               209                                                                               49.535                                                                             5.367                                                                              12.787                                                                             1.00                                                                              19.26                                        ATOM  1146                                                                              CA  LEU                                                                               209                                                                               49.635                                                                             4.286                                                                              11.777                                                                             1.00                                                                              16.77                                        ATOM  1147                                                                              CB  LEU                                                                               209                                                                               48.271                                                                             3.966                                                                              11.168                                                                             1.00                                                                              13.38                                        ATOM  1148                                                                              CG  LEU                                                                               209                                                                               47.330                                                                             3.000                                                                              11.874                                                                             1.00                                                                              13.06                                        ATOM  1149                                                                              CD1 LEU                                                                               209                                                                               45.921                                                                             3.206                                                                              11.379                                                                             1.00                                                                              7.67                                         ATOM  1150                                                                              CD2 LEU                                                                               209                                                                               47.779                                                                             1.568                                                                              11.664                                                                             1.00                                                                              14.89                                        ATOM  1151                                                                              C   LEU                                                                               209                                                                               50.621                                                                             4.596                                                                              10.639                                                                             1.00                                                                              16.38                                        ATOM  1152                                                                              O   LEU                                                                               209                                                                               51.370                                                                             3.721                                                                              10.186                                                                             1.00                                                                              17.07                                        ATOM  1153                                                                              N   LYS                                                                               210                                                                               50.635                                                                             5.842                                                                              10.187                                                                             1.00                                                                              13.88                                        ATOM  1154                                                                              CA  LYS                                                                               210                                                                               51.536                                                                             6.208                                                                              9.129                                                                              1.00                                                                              14.30                                        ATOM  1155                                                                              CB  LYS                                                                               210                                                                               51.220                                                                             7.624                                                                              8.608                                                                              1.00                                                                              11.99                                        ATOM  1156                                                                              CG  LYS                                                                               210                                                                               51.477                                                                             8.779                                                                              9.526                                                                              1.00                                                                              7.35                                         ATOM  1157                                                                              CD  LYS                                                                               210                                                                               52.797                                                                             9.443                                                                              9.221                                                                              1.00                                                                              6.42                                         ATOM  1158                                                                              CE  LYS                                                                               210                                                                               53.002                                                                             10.669                                                                             10.085                                                                             1.00                                                                              6.47                                         ATOM  1159                                                                              NZ  LYS                                                                               210                                                                               53.263                                                                             10.313                                                                             11.513                                                                             1.00                                                                              14.19                                        ATOM  1160                                                                              C   LYS                                                                               210                                                                               53.008                                                                             6.020                                                                              9.523                                                                              1.00                                                                              17.24                                        ATOM  1161                                                                              O   LYS                                                                               210                                                                               53.845                                                                             5.688                                                                              8.670                                                                              1.00                                                                              21.95                                        ATOM  1162                                                                              N   ASP                                                                               211                                                                               53.306                                                                             6.139                                                                              10.819                                                                             1.00                                                                              19.90                                        ATOM  1163                                                                              CA  ASP                                                                               211                                                                               54.670                                                                             5.983                                                                              11.336                                                                             1.00                                                                              16.45                                        ATOM  1164                                                                              CB  ASP                                                                               211                                                                               54.685                                                                             6.109                                                                              12.854                                                                             1.00                                                                              11.34                                        ATOM  1165                                                                              CG  ASP                                                                               211                                                                               54.823                                                                             7.529                                                                              13.326                                                                             1.00                                                                              13.51                                        ATOM  1166                                                                              OD1 ASP                                                                               211                                                                               55.048                                                                             8.445                                                                              12.522                                                                             1.00                                                                              11.47                                        ATOM  1167                                                                              OD2 ASP                                                                               211                                                                               54.742                                                                             7.740                                                                              14.545                                                                             1.00                                                                              19.85                                        ATOM  1168                                                                              C   ASP                                                                               211                                                                               55.219                                                                             4.628                                                                              10.945                                                                             1.00                                                                              16.72                                        ATOM  1169                                                                              O   ASP                                                                               211                                                                               56.424                                                                             4.461                                                                              10.749                                                                             1.00                                                                              21.07                                        ATOM  1170                                                                              N   ALA                                                                               212                                                                               54.307                                                                             3.679                                                                              10.778                                                                             1.00                                                                              15.96                                        ATOM  1171                                                                              CA  ALA                                                                               212                                                                               54.638                                                                             2.317                                                                              10.395                                                                             1.00                                                                              13.35                                        ATOM  1172                                                                              CB  ALA                                                                               212                                                                               53.406                                                                             1.453                                                                              10.450                                                                             1.00                                                                              9.60                                         ATOM  1173                                                                              C   ALA                                                                               212                                                                               55.246                                                                             2.251                                                                              9.001                                                                              1.00                                                                              17.10                                        ATOM  1174                                                                              O   ALA                                                                               212                                                                               56.055                                                                             1.368                                                                              8.735                                                                              1.00                                                                              21.49                                        ATOM  1175                                                                              N   GLN                                                                               213                                                                               54.860                                                                             3.181                                                                              8.122                                                                              1.00                                                                              17.33                                        ATOM  1176                                                                              CA  GLN                                                                               213                                                                               55.345                                                                             3.228                                                                              6.740                                                                              1.00                                                                              14.16                                        ATOM  1177                                                                              CB  GLN                                                                               213                                                                               54.295                                                                             3.896                                                                              5.838                                                                              1.00                                                                              13.57                                        ATOM  1178                                                                              CG  GLN                                                                               213                                                                               52.895                                                                             3.233                                                                              5.913                                                                              1.00                                                                              8.05                                         ATOM  1179                                                                              CD  GLN                                                                               213                                                                               52.956                                                                             1.733                                                                              5.680                                                                              1.00                                                                              9.09                                         ATOM  1180                                                                              OE1 GLN                                                                               213                                                                               53.641                                                                             1.288                                                                              4.777                                                                              1.00                                                                              13.24                                        ATOM  1181                                                                              NE2 GLN                                                                               213                                                                               52.284                                                                             0.950                                                                              6.518                                                                              1.00                                                                              7.98                                         ATOM  1182                                                                              C   GLN                                                                               213                                                                               56.681                                                                             3.948                                                                              6.661                                                                              1.00                                                                              17.76                                        ATOM  1183                                                                              O   GLN                                                                               213                                                                               57.479                                                                             3.716                                                                              5.752                                                                              1.00                                                                              22.36                                        ATOM  1184                                                                              N   VAL                                                                               214                                                                               56.918                                                                             4.838                                                                              7.614                                                                              1.00                                                                              16.49                                        ATOM  1185                                                                              CA  VAL                                                                               214                                                                               58.181                                                                             5.567                                                                              7.689                                                                              1.00                                                                              16.94                                        ATOM  1186                                                                              CB  VAL                                                                               214                                                                               58.008                                                                             6.922                                                                              8.418                                                                              1.00                                                                              17.23                                        ATOM  1187                                                                              CG1 VAL                                                                               214                                                                               59.328                                                                             7.615                                                                              8.598                                                                              1.00                                                                              17.53                                        ATOM  1188                                                                              CG2 VAL                                                                               214                                                                               57.076                                                                             7.809                                                                              7.631                                                                              1.00                                                                              17.23                                        ATOM  1189                                                                              C   VAL                                                                               214                                                                               59.261                                                                             4.731                                                                              8.396                                                                              1.00                                                                              15.03                                        ATOM  1190                                                                              O   VAL                                                                               214                                                                               60.314                                                                             4.506                                                                              7.833                                                                              1.00                                                                              12.50                                        ATOM  1191                                                                              N   PHE                                                                               215                                                                               58.961                                                                             4.188                                                                              9.576                                                                              1.00                                                                              18.28                                        ATOM  1192                                                                              CA  PHE                                                                               215                                                                               59.943                                                                             3.422                                                                              10.350                                                                             1.00                                                                              13.37                                        ATOM  1193                                                                              CB  PHE                                                                               215                                                                               59.892                                                                             3.849                                                                              11.805                                                                             1.00                                                                              14.35                                        ATOM  1194                                                                              CG  PHE                                                                               215                                                                               60.044                                                                             5.306                                                                              12.011                                                                             1.00                                                                              12.08                                        ATOM  1195                                                                              CD1 PHE                                                                               215                                                                               58.932                                                                             6.092                                                                              12.281                                                                             1.00                                                                              13.84                                        ATOM  1196                                                                              CD2 PHE                                                                               215                                                                               61.284                                                                             5.903                                                                              11.895                                                                             1.00                                                                              11.02                                        ATOM  1197                                                                              CE1 PHE                                                                               215                                                                               59.052                                                                             7.459                                                                              12.425                                                                             1.00                                                                              11.98                                        ATOM  1198                                                                              CE2 PHE                                                                               215                                                                               61.420                                                                             7.264                                                                              12.038                                                                             1.00                                                                              16.66                                        ATOM  1199                                                                              CZ  PHE                                                                               215                                                                               60.294                                                                             8.052                                                                              12.302                                                                             1.00                                                                              17.15                                        ATOM  1200                                                                              C   PHE                                                                               215                                                                               59.854                                                                             1.906                                                                              10.341                                                                             1.00                                                                              15.97                                        ATOM  1201                                                                              O   PHE                                                                               215                                                                               60.826                                                                             1.243                                                                              10.675                                                                             1.00                                                                              19.35                                        ATOM  1202                                                                              N   GLY                                                                               216                                                                               58.700                                                                             1.355                                                                              9.981                                                                              1.00                                                                              16.28                                        ATOM  1203                                                                              CA  GLY                                                                               216                                                                               58.505                                                                             -0.087                                                                             9.975                                                                              1.00                                                                              16.57                                        ATOM  1204                                                                              C   GLY                                                                               216                                                                               59.707                                                                             -0.955                                                                             9.654                                                                              1.00                                                                              21.88                                        ATOM  1205                                                                              O   GLY                                                                               216                                                                               60.073                                                                             -1.849                                                                             10.433                                                                             1.00                                                                              19.41                                        ATOM  1206                                                                              N   GLU                                                                               217                                                                               60.342                                                                             -0.672                                                                             8.521                                                                              1.00                                                                              24.90                                        ATOM  1207                                                                              CA  GLU                                                                               217                                                                               61.488                                                                             -1.439                                                                             8.085                                                                              1.00                                                                              28.00                                        ATOM  1208                                                                              CB  GLU                                                                               217                                                                               61.919                                                                             -1.027                                                                             6.688                                                                              1.00                                                                              35.93                                        ATOM  1209                                                                              CG  GLU                                                                               217                                                                               63.039                                                                             -1.914                                                                             6.163                                                                              1.00                                                                              51.31                                        ATOM  1210                                                                              CD  GLU                                                                               217                                                                               63.279                                                                             -1.749                                                                             4.683                                                                              1.00                                                                              59.93                                        ATOM  1211                                                                              OE1 GLU                                                                               217                                                                               62.298                                                                             -1.817                                                                             3.904                                                                              1.00                                                                              65.77                                        ATOM  1212                                                                              OE2 GLU                                                                               217                                                                               64.456                                                                             -1.556                                                                             4.302                                                                              1.00                                                                              68.04                                        ATOM  1213                                                                              C   GLU                                                                               217                                                                               62.679                                                                             -1.407                                                                             9.025                                                                              1.00                                                                              27.28                                        ATOM  1214                                                                              O   GLU                                                                               217                                                                               63.299                                                                             -2.446                                                                             9.260                                                                              1.00                                                                              31.56                                        ATOM  1215                                                                              N   GLU                                                                               218                                                                               63.029                                                                             -0.229                                                                             9.535                                                                              1.00                                                                              22.80                                        ATOM  1216                                                                              CA  GLU                                                                               218                                                                               64.149                                                                             -0.126                                                                             10.462                                                                             1.00                                                                              19.69                                        ATOM  1217                                                                              CB  GLU                                                                               218                                                                               64.705                                                                             1.302                                                                              10.527                                                                             1.00                                                                              19.03                                        ATOM  1218                                                                              CG  GLU                                                                               218                                                                               63.743                                                                             2.371                                                                              10.982                                                                             1.00                                                                              23.93                                        ATOM  1219                                                                              CD  GLU                                                                               218                                                                               64.270                                                                             3.783                                                                              10.738                                                                             1.00                                                                              31.49                                        ATOM  1220                                                                              OE1 GLU                                                                               218                                                                               64.001                                                                             4.706                                                                              11.543                                                                             1.00                                                                              29.38                                        ATOM  1221                                                                              OE2 GLU                                                                               218                                                                               64.949                                                                             3.977                                                                              9.718                                                                              1.00                                                                              38.81                                        ATOM  1222                                                                              C   GLU                                                                               218                                                                               63.794                                                                             -0.646                                                                             11.850                                                                             1.00                                                                              17.19                                        ATOM  1223                                                                              O   GLU                                                                               218                                                                               64.669                                                                             -0.990                                                                             12.608                                                                             1.00                                                                              25.19                                        ATOM  1224                                                                              N   TRP                                                                               219                                                                               62.514                                                                             -0.735                                                                             12.168                                                                             1.00                                                                              13.68                                        ATOM  1225                                                                              CA  TRP                                                                               219                                                                               62.078                                                                             -1.230                                                                             13.452                                                                             1.00                                                                              11.22                                        ATOM  1226                                                                              CB  TRP                                                                               219                                                                               60.638                                                                             -0.816                                                                             13.740                                                                             1.00                                                                              15.63                                        ATOM  1227                                                                              CG  TRP                                                                               219                                                                               60.475                                                                             0.563                                                                              14.192                                                                             1.00                                                                              19.27                                        ATOM  1228                                                                              CD2 TRP                                                                               219                                                                               59.249                                                                             1.297                                                                              14.263                                                                             1.00                                                                              17.84                                        ATOM  1229                                                                              CE2 TRP                                                                               219                                                                               59.555                                                                             2.568                                                                              14.791                                                                             1.00                                                                              16.01                                        ATOM  1230                                                                              CE3 TRP                                                                               219                                                                               57.918                                                                             1.000                                                                              13.924                                                                             1.00                                                                              22.82                                        ATOM  1231                                                                              CD1 TRP                                                                               219                                                                               61.450                                                                             1.395                                                                              14.658                                                                             1.00                                                                              20.82                                        ATOM  1232                                                                              NE1 TRP                                                                               219                                                                               60.903                                                                             2.600                                                                              15.021                                                                             1.00                                                                              21.26                                        ATOM  1233                                                                              CZ2 TRP                                                                               219                                                                               58.589                                                                             3.547                                                                              14.992                                                                             1.00                                                                              17.84                                        ATOM  1234                                                                              CZ3 TRP                                                                               219                                                                               56.945                                                                             1.982                                                                              14.121                                                                             1.00                                                                              20.61                                        ATOM  1235                                                                              CH2 TRP                                                                               219                                                                               57.289                                                                             3.238                                                                              14.651                                                                             1.00                                                                              24.23                                        ATOM  1236                                                                              C   TRP                                                                               219                                                                               62.093                                                                             -2.729                                                                             13.468                                                                             1.00                                                                              12.69                                        ATOM  1237                                                                              O   TRP                                                                               219                                                                               61.905                                                                             -3.326                                                                             14.498                                                                             1.00                                                                              20.36                                        ATOM  1238                                                                              N   GLY                                                                               220                                                                               62.215                                                                             -3.370                                                                             12.331                                                                             1.00                                                                              14.83                                        ATOM  1239                                                                              CA  GLY                                                                               220                                                                               62.209                                                                             -4.816                                                                             12.384                                                                             1.00                                                                              15.91                                        ATOM  1240                                                                              C   GLY                                                                               220                                                                               60.923                                                                             -5.447                                                                             11.862                                                                             1.00                                                                              19.27                                        ATOM  1241                                                                              O   GLY                                                                               220                                                                               60.858                                                                             -6.662                                                                             11.767                                                                             1.00                                                                              23.97                                        ATOM  1242                                                                              N   TYR                                                                               221                                                                               59.884                                                                             -4.679                                                                             11.563                                                                             1.00                                                                              13.12                                        ATOM  1243                                                                              CA  TYR                                                                               221                                                                               58.684                                                                             -5.297                                                                             11.010                                                                             1.00                                                                              15.79                                        ATOM  1244                                                                              CB  TYR                                                                               221                                                                               57.579                                                                             -4.281                                                                             10.897                                                                             1.00                                                                              14.40                                        ATOM  1245                                                                              CG  TYR                                                                               221                                                                               56.915                                                                             -3.953                                                                             12.186                                                                             1.00                                                                              13.85                                        ATOM  1246                                                                              CD1 TYR                                                                               221                                                                               56.823                                                                             -2.645                                                                             12.607                                                                             1.00                                                                              15.85                                        ATOM  1247                                                                              CE1 TYR                                                                               221                                                                               56.110                                                                             -2.315                                                                             13.725                                                                             1.00                                                                              17.59                                        ATOM  1248                                                                              CD2 TYR                                                                               221                                                                               56.283                                                                             -4.941                                                                             12.939                                                                             1.00                                                                              13.29                                        ATOM  1249                                                                              CE2 TYR                                                                               221                                                                               55.564                                                                             -4.623                                                                             14.063                                                                             1.00                                                                              14.03                                        ATOM  1250                                                                              CZ  TYR                                                                               221                                                                               55.489                                                                             -3.301                                                                             14.443                                                                             1.00                                                                              16.10                                        ATOM  1251                                                                              OH  TYR                                                                               221                                                                               54.791                                                                             -2.942                                                                             15.554                                                                             1.00                                                                              26.08                                        ATOM  1252                                                                              C   TYR                                                                               221                                                                               58.972                                                                             -5.817                                                                             9.595                                                                              1.00                                                                              20.08                                        ATOM  1253                                                                              O   TYR                                                                               221                                                                               59.828                                                                             -5.291                                                                             8.905                                                                              1.00                                                                              25.54                                        ATOM  1254                                                                              N   SER                                                                               222                                                                               58.253                                                                             -6.832                                                                             9.140                                                                              1.00                                                                              22.90                                        ATOM  1255                                                                              CA  SER                                                                               222                                                                               58.481                                                                             -7.354                                                                             7.790                                                                              1.00                                                                              25.01                                        ATOM  1256                                                                              CB  SER                                                                               222                                                                               58.412                                                                             -8.881                                                                             7.807                                                                              1.00                                                                              25.19                                        ATOM  1257                                                                              OG  SER                                                                               222                                                                               57.154                                                                             -9.300                                                                             8.332                                                                              1.00                                                                              30.91                                        ATOM  1258                                                                              C   SER                                                                               222                                                                               57.437                                                                             -6.787                                                                             6.818                                                                              1.00                                                                              23.30                                        ATOM  1259                                                                              O   SER                                                                               222                                                                               56.534                                                                             -6.062                                                                             7.241                                                                              1.00                                                                              24.16                                        ATOM  1260                                                                              N   SER                                                                               223                                                                               57.542                                                                             -7.159                                                                             5.539                                                                              1.00                                                                              24.20                                        ATOM  1261                                                                              CA  SER                                                                               223                                                                               56.613                                                                             -6.7.05                                                                            4.486                                                                              1.00                                                                              22.69                                        ATOM  1262                                                                              CB  SER                                                                               223                                                                               56.827                                                                             -7.473                                                                             3.162                                                                              1.00                                                                              25.01                                        ATOM  1263                                                                              OG  SER                                                                               223                                                                               57.699                                                                             -6.777                                                                             2.293                                                                              1.00                                                                              30.78                                        ATOM  1264                                                                              C   SER                                                                               223                                                                               55.178                                                                             -6.882                                                                             4.910                                                                              1.00                                                                              18.96                                        ATOM  1265                                                                              O   SER                                                                               223                                                                               54.408                                                                             -5.924                                                                             4.904                                                                              1.00                                                                              24.83                                        ATOM  1266                                                                              N   GLU                                                                               224                                                                               54.849                                                                             -8.100                                                                             5.331                                                                              1.00                                                                              14.34                                        ATOM  1267                                                                              CA  GLU                                                                               224                                                                               53.510                                                                             -8.430                                                                             5.768                                                                              1.00                                                                              14.70                                        ATOM  1268                                                                              CB  GLU                                                                               224                                                                               53.452                                                                             -9.881                                                                             6.241                                                                              1.00                                                                              11.94                                        ATOM  1269                                                                              CG  GLU                                                                               224                                                                               53.594                                                                             -10.917                                                                            5.139                                                                              1.00                                                                              6.62                                         ATOM  1270                                                                              CD  GLU                                                                               224                                                                               55.008                                                                             -11.084                                                                            4.574                                                                              1.00                                                                              11.92                                        ATOM  1271                                                                              OE1 GLU                                                                               224                                                                               56.032                                                                             -10.939                                                                            5.277                                                                              1.00                                                                              17.07                                        ATOM  1272                                                                              OE2 GLU                                                                               224                                                                               55.100                                                                             -11.431                                                                            3.392                                                                              1.00                                                                              19.14                                        ATOM  1273                                                                              C   GLU                                                                               224                                                                               53.020                                                                             -7.494                                                                             6.860                                                                              1.00                                                                              16.93                                        ATOM  1274                                                                              O   GLU                                                                               224                                                                               51.982                                                                             -6.859                                                                             6.719                                                                              1.00                                                                              23.58                                        ATOM  1275                                                                              N   ASP                                                                               225                                                                               53.794                                                                             -7.368                                                                             7.928                                                                              1.00                                                                              21.13                                        ATOM  1276                                                                              CA  ASP                                                                               225                                                                               53.423                                                                             -6.518                                                                             9.037                                                                              1.00                                                                              14.44                                        ATOM  1277                                                                              CB  ASP                                                                               225                                                                               54.554                                                                             -6.451                                                                             10.050                                                                             1.00                                                                              20.30                                        ATOM  1278                                                                              CG  ASP                                                                               225                                                                               54.686                                                                             -7.712                                                                             10.863                                                                             1.00                                                                              22.22                                        ATOM  1279                                                                              OD1 ASP                                                                               225                                                                               53.700                                                                             -8.071                                                                             11.531                                                                             1.00                                                                              22.32                                        ATOM  1280                                                                              OD2 ASP                                                                               225                                                                               55.782                                                                             -8.315                                                                             10.861                                                                             1.00                                                                              18.56                                        ATOM  1281                                                                              C   ASP                                                                               225                                                                               53.156                                                                             -5.127                                                                             8.534                                                                              1.00                                                                              19.11                                        ATOM  1282                                                                              O   ASP                                                                               225                                                                               52.081                                                                             -4.583                                                                             8.761                                                                              1.00                                                                              22.45                                        ATOM  1283                                                                              N   VAL                                                                               226                                                                               54.130                                                                             -4.547                                                                             7.843                                                                              1.00                                                                              17.57                                        ATOM  1284                                                                              CA  VAL                                                                               226                                                                               53.972                                                                             -3.206                                                                             7.332                                                                              1.00                                                                              18.36                                        ATOM  1285                                                                              CB  VAL                                                                               226                                                                               55.266                                                                             -2.702                                                                             6.681                                                                              1.00                                                                              17.30                                        ATOM  1286                                                                              CG1 VAL                                                                               226                                                                               55.029                                                                             -1.374                                                                             6.029                                                                              1.00                                                                              16.11                                        ATOM  1287                                                                              CG2 VAL                                                                               226                                                                               56.345                                                                             -2.540                                                                             7.739                                                                              1.00                                                                              16.32                                        ATOM  1288                                                                              C   VAL                                                                               226                                                                               52.762                                                                             -3.050                                                                             6.392                                                                              1.00                                                                              20.92                                        ATOM  1289                                                                              O   VAL                                                                               226                                                                               52.072                                                                             -2.031                                                                             6.467                                                                              1.00                                                                              24.32                                        ATOM  1290                                                                              N   ALA                                                                               227                                                                               52.472                                                                             -4.051                                                                             5.551                                                                              1.00                                                                              19.82                                        ATOM  1291                                                                              CA  ALA                                                                               227                                                                               51.314                                                                             -3.986                                                                             4.634                                                                              1.00                                                                              19.35                                        ATOM  1292                                                                              CB  ALA                                                                               227                                                                               51.397                                                                             -5.063                                                                             3.574                                                                              1.00                                                                              15.70                                        ATOM  1293                                                                              C   ALA                                                                               227                                                                               49.962                                                                             -4.081                                                                             5.380                                                                              1.00                                                                              19.98                                        ATOM  1294                                                                              O   ALA                                                                               227                                                                               48.943                                                                             -3.530                                                                             4.945                                                                              1.00                                                                              21.24                                        ATOM  1295                                                                              N   GLU                                                                               228                                                                               49.947                                                                             -4.797                                                                             6.493                                                                              1.00                                                                              16.52                                        ATOM  1296                                                                              CA  GLU                                                                               228                                                                               48.735                                                                             -4.905                                                                             7.275                                                                              1.00                                                                              15.88                                        ATOM  1297                                                                              CB  GLU                                                                               228                                                                               48.932                                                                             -5.920                                                                             8.395                                                                              1.00                                                                              18.82                                        ATOM  1298                                                                              CG  GLU                                                                               228                                                                               48.725                                                                             -7.341                                                                             7.906                                                                              1.00                                                                              23.82                                        ATOM  1299                                                                              CD  GLU                                                                               228                                                                               49.723                                                                             -8.330                                                                             8.473                                                                              1.00                                                                              28.53                                        ATOM  1300                                                                              OE1 GLU                                                                               228                                                                               50.241                                                                             -9.159                                                                             7.694                                                                              1.00                                                                              30.67                                        ATOM  1301                                                                              OE2 GLU                                                                               228                                                                               49.979                                                                             -8.296                                                                             9.692                                                                              1.00                                                                              32.83                                        ATOM  1302                                                                              C   GLU                                                                               228                                                                               48.381                                                                             -3.535                                                                             7.812                                                                              1.00                                                                              12.58                                        ATOM  1303                                                                              O   GLU                                                                               228                                                                               47.222                                                                             -3.150                                                                             7.817                                                                              1.00                                                                              15.95                                        ATOM  1304                                                                              N   PHE                                                                               229                                                                               49.398                                                                             -2.785                                                                             8.222                                                                              1.00                                                                              13.17                                        ATOM  1305                                                                              CA  PHE                                                                               229                                                                               49.207                                                                             -1.438                                                                             8.730                                                                              1.00                                                                              13.77                                        ATOM  1306                                                                              CB  PHE                                                                               229                                                                               50.512                                                                             -0.911                                                                             9.340                                                                              1.00                                                                              13.96                                        ATOM  1307                                                                              CG  PHE                                                                               229                                                                               50.856                                                                             -1.526                                                                             10.682                                                                             1.00                                                                              12.34                                        ATOM  1308                                                                              CD1 PHE                                                                               229                                                                               52.140                                                                             -2.010                                                                             10.944                                                                             1.00                                                                              12.39                                        ATOM  1309                                                                              CD2 PHE                                                                               229                                                                               49.890                                                                             -1.636                                                                             11.686                                                                             1.00                                                                              12.04                                        ATOM  1310                                                                              CE1 PHE                                                                               229                                                                               52.454                                                                             -2.597                                                                             12.171                                                                             1.00                                                                              8.60                                         ATOM  1311                                                                              CE2 PHE                                                                               229                                                                               50.207                                                                             -2.224                                                                             12.928                                                                             1.00                                                                              9.34                                         ATOM  1312                                                                              CZ  PHE                                                                               229                                                                               51.479                                                                             -2.701                                                                             13.164                                                                             1.00                                                                              6.27                                         ATOM  1313                                                                              C   PHE                                                                               229                                                                               48.698                                                                             -0.501                                                                             7.623                                                                              1.00                                                                              16.58                                        ATOM  1314                                                                              O   PHE                                                                               229                                                                               47.732                                                                             0.240                                                                              7.829                                                                              1.00                                                                              17.11                                        ATOM  1315                                                                              N   TYR                                                                               230                                                                               49.321                                                                             -0.545                                                                             6.443                                                                              1.00                                                                              17.83                                        ATOM  1316                                                                              CA  TYR                                                                               230                                                                               48.889                                                                             0.306                                                                              5.308                                                                              1.00                                                                              18.63                                        ATOM  1317                                                                              CB  TYR                                                                               230                                                                               49.775                                                                             0.095                                                                              4.085                                                                              1.00                                                                              17.05                                        ATOM  1318                                                                              CG  TYR                                                                               230                                                                               49.660                                                                             1.160                                                                              3.027                                                                              1.00                                                                              19.90                                        ATOM  1319                                                                              CD1 TYR                                                                               230                                                                               50.175                                                                             2.435                                                                              3.245                                                                              1.00                                                                              20.56                                        ATOM  1320                                                                              CE1 TYR                                                                               230                                                                               50.141                                                                             3.410                                                                              2.266                                                                              1.00                                                                              17.60                                        ATOM  1321                                                                              CD2 TYR                                                                               230                                                                               49.092                                                                             0.887                                                                              1.786                                                                              1.00                                                                              20.54                                        ATOM  1322                                                                              CE2 TYR                                                                               230                                                                               49.048                                                                             1.858                                                                              0.798                                                                              1.00                                                                              21.92                                        ATOM  1323                                                                              CZ  TYR                                                                               230                                                                               49.583                                                                             3.121                                                                              1.047                                                                              1.00                                                                              24.08                                        ATOM  1324                                                                              OH  TYR                                                                               230                                                                               49.569                                                                             4.100                                                                              0.079                                                                              1.00                                                                              22.12                                        ATOM  1325                                                                              C   TYR                                                                               230                                                                               47.452                                                                             -0.014                                                                             4.941                                                                              1.00                                                                              14.05                                        ATOM  1326                                                                              O   TYR                                                                               230                                                                               46.630                                                                             0.873                                                                              4.867                                                                              1.00                                                                              18.48                                        ATOM  1327                                                                              N   HIS                                                                               231                                                                               47.152                                                                             -1.288                                                                             4.724                                                                              1.00                                                                              15.20                                        ATOM  1328                                                                              CA  HIS                                                                               231                                                                               45.789                                                                             -1.698                                                                             4.408                                                                              1.00                                                                              16.34                                        ATOM  1329                                                                              CB  HIS                                                                               231                                                                               45.657                                                                             -3.218                                                                             4.400                                                                              1.00                                                                              19.85                                        ATOM  1330                                                                              CG  HIS                                                                               231                                                                               46.101                                                                             -3.869                                                                             3.126                                                                              1.00                                                                              27.74                                        ATOM  1331                                                                              CD2 HIS                                                                               231                                                                               47.267                                                                             -3.787                                                                             2.433                                                                              1.00                                                                              30.71                                        ATOM  1332                                                                              ND1 HIS                                                                               231                                                                               45.308                                                                             -4.754                                                                             2.423                                                                              1.00                                                                              28.38                                        ATOM  1333                                                                              CE1 HIS                                                                               231                                                                               45.963                                                                             -5.185                                                                             1.361                                                                              1.00                                                                              29.98                                        ATOM  1334                                                                              NE2 HIS                                                                               231                                                                               47.155                                                                             -4.612                                                                             1.343                                                                              1.00                                                                              22.31                                        ATOM  1335                                                                              C   HIS                                                                               231                                                                               44.846                                                                             -1.125                                                                             5.466                                                                              1.00                                                                              18.40                                        ATOM  1336                                                                              O   HIS                                                                               231                                                                               43.840                                                                             -0.507                                                                             5.141                                                                              1.00                                                                              27.16                                        ATOM  1337                                                                              N   ARG                                                                               232                                                                               45.192                                                                             -1.281                                                                             6.735                                                                              1.00                                                                              18.07                                        ATOM  1338                                                                              CA  ARG                                                                               232                                                                               44.354                                                                             -0.766                                                                             7.806                                                                              1.00                                                                              15.74                                        ATOM  1339                                                                              CB  ARG                                                                               232                                                                               44.940                                                                             -1.137                                                                             9.171                                                                              1.00                                                                              22.99                                        ATOM  1340                                                                              CG  ARG                                                                               232                                                                               44.049                                                                             -0.764                                                                             10.379                                                                             1.00                                                                              22.30                                        ATOM  1341                                                                              CD  ARG                                                                               232                                                                               44.601                                                                             -1.380                                                                             11.641                                                                             1.00                                                                              25.70                                        ATOM  1342                                                                              NE  ARG                                                                               232                                                                               44.646                                                                             -2.838                                                                             11.520                                                                             1.00                                                                              33.18                                        ATOM  1343                                                                              CZ  ARG                                                                               232                                                                               45.690                                                                             -3.613                                                                             11.826                                                                             1.00                                                                              33.26                                        ATOM  1344                                                                              NH1 ARG                                                                               232                                                                               46.835                                                                             -3.093                                                                             12.292                                                                             1.00                                                                              22.03                                        ATOM  1345                                                                              NH2 ARG                                                                               232                                                                               45.572                                                                             -4.932                                                                             11.658                                                                             1.00                                                                              35.05                                        ATOM  1346                                                                              C   ARG                                                                               232                                                                               44.202                                                                             0.738                                                                              7.727                                                                              1.00                                                                              17.28                                        ATOM  1347                                                                              O   ARG                                                                               232                                                                               43.099                                                                             1.246                                                                              7.931                                                                              1.00                                                                              15.75                                        ATOM  1348                                                                              N   GLN                                                                               233                                                                               45.300                                                                             1.448                                                                              7.431                                                                              1.00                                                                              16.95                                        ATOM  1349                                                                              CA  GLN                                                                               233                                                                               45.272                                                                             2.903                                                                              7.343                                                                              1.00                                                                              10.93                                        ATOM  1350                                                                              CB  GLN                                                                               233                                                                               46.656                                                                             3.455                                                                              7.062                                                                              1.00                                                                              12.92                                        ATOM  1351                                                                              CG  GLN                                                                               233                                                                               46.688                                                                             4.957                                                                              6.820                                                                              1.00                                                                              7.74                                         ATOM  1352                                                                              CD  GLN                                                                               233                                                                               48.094                                                                             5.498                                                                              6.787                                                                              1.00                                                                              9.89                                         ATOM  1353                                                                              OE1 GLN                                                                               233                                                                               49.047                                                                             4.762                                                                              6.991                                                                              1.00                                                                              7.65                                         ATOM  1354                                                                              NE2 GLN                                                                               233                                                                               48.227                                                                             6.795                                                                              6.603                                                                              1.00                                                                              10.54                                        ATOM  1355                                                                              C   GLN                                                                               233                                                                               44.310                                                                             3.360                                                                              6.264                                                                              1.00                                                                              15.42                                        ATOM  1356                                                                              O   GLN                                                                               233                                                                               43.520                                                                             4.295                                                                              6.480                                                                              1.00                                                                              17.48                                        ATOM  1357                                                                              N   LEU                                                                               234                                                                               44.360                                                                             2.707                                                                              5.104                                                                              1.00                                                                              11.75                                        ATOM  1358                                                                              CA  LEU                                                                               234                                                                               43.467                                                                             3.080                                                                              4.018                                                                              1.00                                                                              11.38                                        ATOM  1359                                                                              CB  LEU                                                                               234                                                                               43.788                                                                             2.276                                                                              2.753                                                                              1.00                                                                              15.07                                        ATOM  1360                                                                              CG  LEU                                                                               234                                                                               45.197                                                                             2.340                                                                              2.165                                                                              1.00                                                                              16.15                                        ATOM  1361                                                                              CD1 LEU                                                                               234                                                                               45.214                                                                             1.734                                                                              0.753                                                                              1.00                                                                              16.02                                        ATOM  1362                                                                              CD2 LEU                                                                               234                                                                               45.639                                                                             3.778                                                                              2.121                                                                              1.00                                                                              15.26                                        ATOM  1363                                                                              C   LEU                                                                               234                                                                               42.003                                                                             2.849                                                                              4.420                                                                              1.00                                                                              12.48                                        ATOM  1364                                                                              O   LEU                                                                               234                                                                               41.157                                                                             3.716                                                                              4.243                                                                              1.00                                                                              19.53                                        ATOM  1365                                                                              N   LYS                                                                               235                                                                               41.727                                                                             1.681                                                                              4.982                                                                              1.00                                                                              13.76                                        ATOM  1366                                                                              CA  LYS                                                                               235                                                                               40.396                                                                             1.277                                                                              5.413                                                                              1.00                                                                              15.08                                        ATOM  1367                                                                              CB  LYS                                                                               235                                                                               40.483                                                                             -0.131                                                                             5.970                                                                              1.00                                                                              20.96                                        ATOM  1368                                                                              CG  LYS                                                                               235                                                                               39.259                                                                             -0.982                                                                             5.768                                                                              1.00                                                                              30.47                                        ATOM  1369                                                                              CD  LYS                                                                               235                                                                               39.452                                                                             -2.367                                                                             6.394                                                                              1.00                                                                              40.95                                        ATOM  1370                                                                              CE  LYS                                                                               235                                                                               40.776                                                                             -3.043                                                                             5.947                                                                              1.00                                                                              49.89                                        ATOM  1371                                                                              NZ  LYS                                                                               235                                                                               41.705                                                                             -3.351                                                                             7.117                                                                              1.00                                                                              50.92                                        ATOM  1372                                                                              C   LYS                                                                               235                                                                               39.802                                                                             2.186                                                                              6.470                                                                              1.00                                                                              18.56                                        ATOM  1373                                                                              O   LYS                                                                               235                                                                               38.613                                                                             2.442                                                                              6.462                                                                              1.00                                                                              22.95                                        ATOM  1374                                                                              N   LEU                                                                               236                                                                               40.619                                                                             2.649                                                                              7.410                                                                              1.00                                                                              21.51                                        ATOM  1375                                                                              CA  LEU                                                                               236                                                                               40.134                                                                             3.538                                                                              8.462                                                                              1.00                                                                              14.99                                        ATOM  1376                                                                              CB  LEU                                                                               236                                                                               41.000                                                                             3.415                                                                              9.708                                                                              1.00                                                                              19.28                                        ATOM  1377                                                                              CG  LEU                                                                               236                                                                               40.947                                                                             1.987                                                                              10.248                                                                             1.00                                                                              17.90                                        ATOM  1378                                                                              CD1 LEU                                                                               236                                                                               41.728                                                                             1.889                                                                              11.495                                                                             1.00                                                                              22.07                                        ATOM  1379                                                                              CD2 LEU                                                                               236                                                                               39.531                                                                             1.624                                                                              10.530                                                                             1.00                                                                              21.26                                        ATOM  1380                                                                              C   LEU                                                                               236                                                                               40.028                                                                             4.981                                                                              8.019                                                                              1.00                                                                              17.01                                        ATOM  1381                                                                              O   LEU                                                                               236                                                                               39.148                                                                             5.701                                                                              8.477                                                                              1.00                                                                              20.51                                        ATOM  1382                                                                              N   THR                                                                               237                                                                               40.907                                                                             5.427                                                                              7.129                                                                              1.00                                                                              16.17                                        ATOM  1383                                                                              CA  THR                                                                               237                                                                               40.808                                                                             6.803                                                                              6.642                                                                              1.00                                                                              15.50                                        ATOM  1384                                                                              CB  THR                                                                               237                                                                               41.824                                                                             7.070                                                                              5.543                                                                              1.00                                                                              15.39                                        ATOM  1385                                                                              OG1 THR                                                                               237                                                                               43.144                                                                             6.962                                                                              6.077                                                                              1.00                                                                              17.24                                        ATOM  1386                                                                              CG2 THR                                                                               237                                                                               41.627                                                                             8.446                                                                              4.968                                                                              1.00                                                                              16.40                                        ATOM  1387                                                                              C   THR                                                                               237                                                                               39.414                                                                             6.972                                                                              6.028                                                                              1.00                                                                              20.09                                        ATOM  1388                                                                              O   THR                                                                               237                                                                               38.776                                                                             8.002                                                                              6.162                                                                              1.00                                                                              20.01                                        ATOM  1389                                                                              N   GLN                                                                               238                                                                               38.960                                                                             5.933                                                                              5.343                                                                              1.00                                                                              23.44                                        ATOM  1390                                                                              CA  GLN                                                                               238                                                                               37.670                                                                             5.948                                                                              4.714                                                                              1.00                                                                              24.58                                        ATOM  1391                                                                              CB  GLN                                                                               238                                                                               37.559                                                                             4.775                                                                              3.738                                                                              1.00                                                                              24.07                                        ATOM  1392                                                                              CG  GLN                                                                               238                                                                               36.197                                                                             4.628                                                                              3.068                                                                              1.00                                                                              28.51                                        ATOM  1393                                                                              CD  GLN                                                                               238                                                                               35.322                                                                             3.583                                                                              3.724                                                                              1.00                                                                              31.81                                        ATOM  1394                                                                              OE1 GLN                                                                               238                                                                               34.185                                                                             3.857                                                                              4.136                                                                              1.00                                                                              34.84                                        ATOM  1395                                                                              NE2 GLN                                                                               238                                                                               35.840                                                                             2.367                                                                              3.816                                                                              1.00                                                                              34.59                                        ATOM  1396                                                                              C   GLN                                                                               238                                                                               36.614                                                                             5.861                                                                              5.801                                                                              1.00                                                                              26.68                                        ATOM  1397                                                                              O   GLN                                                                               238                                                                               35.709                                                                             6.685                                                                              5.855                                                                              1.00                                                                              28.24                                        ATOM  1398                                                                              N   GLN                                                                               239                                                                               36.750                                                                             4.889                                                                              6.693                                                                              1.00                                                                              28.41                                        ATOM  1399                                                                              CA  GLN                                                                               239                                                                               35.777                                                                             4.718                                                                              7.768                                                                              1.00                                                                              26.98                                        ATOM  1400                                                                              CB  GLN                                                                               239                                                                               36.138                                                                             3.536                                                                              8.644                                                                              1.00                                                                              34.27                                        ATOM  1401                                                                              CG  GLN                                                                               239                                                                               35.788                                                                             2.203                                                                              8.062                                                                              1.00                                                                              42.96                                        ATOM  1402                                                                              CD  GLN                                                                               239                                                                               35.792                                                                             1.116                                                                              9.118                                                                              1.00                                                                              51.22                                        ATOM  1403                                                                              OE1 GLN                                                                               239                                                                               35.586                                                                             1.383                                                                              10.318                                                                             1.00                                                                              51.30                                        ATOM  1404                                                                              NE2 GLN                                                                               239                                                                               36.012                                                                             -0.118                                                                             8.685                                                                              1.00                                                                              54.93                                        ATOM  1405                                                                              C   GLN                                                                               239                                                                               35.585                                                                             5.933                                                                              8.644                                                                              1.00                                                                              22.08                                        ATOM  1406                                                                              O   GLN                                                                               239                                                                               34.460                                                                             6.397                                                                              8.793                                                                              1.00                                                                              24.27                                        ATOM  1407                                                                              N   TYR                                                                               240                                                                               36.669                                                                             6.420                                                                              9.257                                                                              1.00                                                                              22.64                                        ATOM  1408                                                                              CA  TYR                                                                               240                                                                               36.626                                                                             7.607                                                                              10.139                                                                             1.00                                                                              20.71                                        ATOM  1409                                                                              CB  TYR                                                                               240                                                                               38.010                                                                             7.923                                                                              10.729                                                                             1.00                                                                              16.77                                        ATOM  1410                                                                              CG  TYR                                                                               240                                                                               38.618                                                                             6.840                                                                              11.637                                                                             1.00                                                                              17.42                                        ATOM  1411                                                                              CD1 TYR                                                                               240                                                                               37.821                                                                             6.001                                                                              12.432                                                                             1.00                                                                              17.36                                        ATOM  1412                                                                              CE1 TYR                                                                               240                                                                               38.400                                                                             5.024                                                                              13.262                                                                             1.00                                                                              17.77                                        ATOM  1413                                                                              CD2 TYR                                                                               240                                                                               40.004                                                                             6.667                                                                              11.703                                                                             1.00                                                                              19.31                                        ATOM  1414                                                                              CE2 TYR                                                                               240                                                                               40.585                                                                             5.698                                                                              12.525                                                                             1.00                                                                              19.41                                        ATOM  1415                                                                              CZ  TYR                                                                               240                                                                               39.781                                                                             4.881                                                                              13.295                                                                             1.00                                                                              19.35                                        ATOM  1416                                                                              OH  TYR                                                                               240                                                                               40.373                                                                             3.879                                                                              14.031                                                                             1.00                                                                              19.37                                        ATOM  1417                                                                              C   TYR                                                                               240                                                                               36.038                                                                             8.858                                                                              9.463                                                                              1.00                                                                              19.71                                        ATOM  1418                                                                              O   TYR                                                                               240                                                                               35.248                                                                             9.588                                                                              10.077                                                                             1.00                                                                              18.91                                        ATOM  1419                                                                              N   THR                                                                               241                                                                               36.422                                                                             9.082                                                                              8.205                                                                              1.00                                                                              20.29                                        ATOM  1420                                                                              CA  THR                                                                               241                                                                               35.938                                                                             10.195                                                                             7.397                                                                              1.00                                                                              16.59                                        ATOM  1421                                                                              CB  THR                                                                               241                                                                               36.619                                                                             10.194                                                                             5.995                                                                              1.00                                                                              21.67                                        ATOM  1422                                                                              OG1 THR                                                                               241                                                                               38.003                                                                             10.546                                                                             6.133                                                                              1.00                                                                              19.88                                        ATOM  1423                                                                              CG2 THR                                                                               241                                                                               35.923                                                                             11.168                                                                             4.990                                                                              1.00                                                                              20.34                                        ATOM  1424                                                                              C   THR                                                                               241                                                                               34.427                                                                             10.065                                                                             7.222                                                                              1.00                                                                              16.73                                        ATOM  1425                                                                              O   THR                                                                               241                                                                               33.672                                                                             10.988                                                                             7.536                                                                              1.00                                                                              20.54                                        ATOM  1426                                                                              N   ASP                                                                               242                                                                               33.982                                                                             8.916                                                                              6.734                                                                              1.00                                                                              17.09                                        ATOM  1427                                                                              CA  ASP                                                                               242                                                                               32.563                                                                             8.690                                                                              6.533                                                                              1.00                                                                              21.69                                        ATOM  1428                                                                              CB  ASP                                                                               242                                                                               32.299                                                                             7.300                                                                              5.954                                                                              1.00                                                                              21.39                                        ATOM  1429                                                                              CG  ASP                                                                               242                                                                               32.603                                                                             7.197                                                                              4.465                                                                              1.00                                                                              20.65                                        ATOM  1430                                                                              OD1 ASP                                                                               242                                                                               32.855                                                                             8.232                                                                              3.813                                                                              1.00                                                                              18.80                                        ATOM  1431                                                                              OD2 ASP                                                                               242                                                                               32.575                                                                             6.058                                                                              3.951                                                                              1.00                                                                              19.59                                        ATOM  1432                                                                              C   ASP                                                                               242                                                                               31.790                                                                             8.839                                                                              7.847                                                                              1.00                                                                              25.51                                        ATOM  1433                                                                              O   ASP                                                                               242                                                                               30.699                                                                             9.423                                                                              7.855                                                                              1.00                                                                              28.83                                        ATOM  1434                                                                              N   HIS                                                                               243                                                                               32.344                                                                             8.354                                                                              8.961                                                                              1.00                                                                              21.95                                        ATOM  1435                                                                              CA  HIS                                                                               243                                                                               31.615                                                                             8.463                                                                              10.220                                                                             1.00                                                                              18.92                                        ATOM  1436                                                                              CB  HIS                                                                               243                                                                               32.309                                                                             7.708                                                                              11.352                                                                             1.00                                                                              17.61                                        ATOM  1437                                                                              CG  HIS                                                                               243                                                                               31.690                                                                             7.935                                                                              12.700                                                                             1.00                                                                              12.62                                        ATOM  1438                                                                              CD2 HIS                                                                               243                                                                               31.795                                                                             8.970                                                                              13.562                                                                             1.00                                                                              14.95                                        ATOM  1439                                                                              ND1 HIS                                                                               243                                                                               30.935                                                                             6.981                                                                              13.349                                                                             1.00                                                                              16.29                                        ATOM  1440                                                                              CE1 HIS                                                                               243                                                                               30.620                                                                             7.411                                                                              14.557                                                                             1.00                                                                              9.95                                         ATOM  1441                                                                              NE2 HIS                                                                               243                                                                               31.130                                                                             8.616                                                                              14.709                                                                             1.00                                                                              16.91                                        ATOM  1442                                                                              C   HIS                                                                               243                                                                               31.383                                                                             9.904                                                                              10.628                                                                             1.00                                                                              21.10                                        ATOM  1443                                                                              O   HIS                                                                               243                                                                               30.301                                                                             10.249                                                                             11.070                                                                             1.00                                                                              25.20                                        ATOM  1444                                                                              N   CYS                                                                               244                                                                               32.413                                                                             10.734                                                                             10.539                                                                             1.00                                                                              20.17                                        ATOM  1445                                                                              CA  CYS                                                                               244                                                                               32.271                                                                             12.128                                                                             10.916                                                                             1.00                                                                              20.48                                        ATOM  1446                                                                              CB  CYS                                                                               244                                                                               33.624                                                                             12.819                                                                             10.883                                                                             1.00                                                                              18.34                                        ATOM  1447                                                                              SG  CYS                                                                               244                                                                               34.760                                                                             12.105                                                                             12.050                                                                             1.00                                                                              16.47                                        ATOM  1448                                                                              C   CYS                                                                               244                                                                               31.269                                                                             12.890                                                                             10.058                                                                             1.00                                                                              21.21                                        ATOM  1449                                                                              O   CYS                                                                               244                                                                               30.462                                                                             13.654                                                                             10.576                                                                             1.00                                                                              22.28                                        ATOM  1450                                                                              N   VAL                                                                               245                                                                               31.312                                                                             12.683                                                                             8.746                                                                              1.00                                                                              22.25                                        ATOM  1451                                                                              CA  VAL                                                                               245                                                                               30.395                                                                             13.376                                                                             7.841                                                                              1.00                                                                              22.33                                        ATOM  1452                                                                              CB  VAL                                                                               245                                                                               30.781                                                                             13.140                                                                             6.359                                                                              1.00                                                                              19.36                                        ATOM  1453                                                                              CG1 VAL                                                                               245                                                                               29.816                                                                             13.827                                                                             5.446                                                                              1.00                                                                              21.10                                        ATOM  1454                                                                              CG2 VAL                                                                               245                                                                               32.171                                                                             13.691                                                                             6.093                                                                              1.00                                                                              17.45                                        ATOM  1455                                                                              C   VAL                                                                               245                                                                               28.957                                                                             12.942                                                                             8.118                                                                              1.00                                                                              21.40                                        ATOM  1456                                                                              O   VAL                                                                               245                                                                               28.055                                                                             13.770                                                                             8.214                                                                              1.00                                                                              22.33                                        ATOM  1457                                                                              N   ASN                                                                               246                                                                               28.780                                                                             11.651                                                                             8.348                                                                              1.00                                                                              21.90                                        ATOM  1458                                                                              CA  ASN                                                                               246                                                                               27.477                                                                             11.063                                                                             8.620                                                                              1.00                                                                              23.19                                        ATOM  1459                                                                              CB  ASN                                                                               246                                                                               27.639                                                                             9.557                                                                              8.771                                                                              1.00                                                                              34.68                                        ATOM  1460                                                                              CG  ASN                                                                               246                                                                               26.366                                                                             8.855                                                                              9.237                                                                              1.00                                                                              44.33                                        ATOM  1461                                                                              OD1 ASN                                                                               246                                                                               25.741                                                                             9.220                                                                              10.248                                                                             1.00                                                                              48.73                                        ATOM  1462                                                                              ND2 ASN                                                                               246                                                                               26.015                                                                             7.790                                                                              8.530                                                                              1.00                                                                              50.65                                        ATOM  1463                                                                              C   ASN                                                                               246                                                                               26.790                                                                             11.631                                                                             9.854                                                                              1.00                                                                              22.82                                        ATOM  1464                                                                              O   ASN                                                                               246                                                                               25.626                                                                             12.038                                                                             9.797                                                                              1.00                                                                              24.79                                        ATOM  1465                                                                              N   TRP                                                                               247                                                                               27.487                                                                             11.615                                                                             10.981                                                                             1.00                                                                              20.19                                        ATOM  1466                                                                              CA  TRP                                                                               247                                                                               26.906                                                                             12.120                                                                             12.208                                                                             1.00                                                                              18.58                                        ATOM  1467                                                                              CB  TRP                                                                               247                                                                               27.694                                                                             11.620                                                                             13.418                                                                             1.00                                                                              17.89                                        ATOM  1468                                                                              CG  TRP                                                                               247                                                                               27.467                                                                             10.185                                                                             13.549                                                                             1.00                                                                              21.14                                        ATOM  1469                                                                              CD2 TRP                                                                               247                                                                               26.199                                                                             9.532                                                                              13.782                                                                             1.00                                                                              22.32                                        ATOM  1470                                                                              CE2 TRP                                                                               247                                                                               26.388                                                                             8.158                                                                              13.537                                                                             1.00                                                                              22.60                                        ATOM  1471                                                                              CE3 TRP                                                                               247                                                                               24.920                                                                             9.982                                                                              14.167                                                                             1.00                                                                              22.25                                        ATOM  1472                                                                              CD1 TRP                                                                               247                                                                               28.337                                                                             9.210                                                                              13.222                                                                             1.00                                                                              23.88                                        ATOM  1473                                                                              NE1 TRP                                                                               247                                                                               27.701                                                                             7.991                                                                              13.194                                                                             1.00                                                                              25.03                                        ATOM  1474                                                                              CZ2 TRP                                                                               247                                                                               25.348                                                                             7.214                                                                              13.659                                                                             1.00                                                                              22.59                                        ATOM  1475                                                                              CZ3 TRP                                                                               247                                                                               23.883                                                                             9.045                                                                              14.289                                                                             1.00                                                                              15.92                                        ATOM  1476                                                                              CH2 TRP                                                                               247                                                                               24.107                                                                             7.679                                                                              14.036                                                                             1.00                                                                              21.52                                        ATOM  1477                                                                              C   TRP                                                                               247                                                                               26.734                                                                             13.619                                                                             12.203                                                                             1.00                                                                              21.26                                        ATOM  1478                                                                              O   TRP                                                                               247                                                                               25.872                                                                             14.151                                                                             12.888                                                                             1.00                                                                              23.07                                        ATOM  1479                                                                              N   TYR                                                                               248                                                                               27.530                                                                             14.291                                                                             11.385                                                                             1.00                                                                              22.21                                        ATOM  1480                                                                              CA  TYR                                                                               248                                                                               27.469                                                                             15.733                                                                             11.270                                                                             1.00                                                                              19.44                                        ATOM  1481                                                                              CB  TYR                                                                               248                                                                               28.634                                                                             16.262                                                                             10.397                                                                             1.00                                                                              22.06                                        ATOM  1482                                                                              CG  TYR                                                                               248                                                                               28.500                                                                             17.715                                                                             9.992                                                                              1.00                                                                              15.39                                        ATOM  1483                                                                              CD1 TYR                                                                               248                                                                               28.656                                                                             18.733                                                                             10.924                                                                             1.00                                                                              18.30                                        ATOM  1484                                                                              CE1 TYR                                                                               248                                                                               28.429                                                                             20.049                                                                             10.589                                                                             1.00                                                                              19.55                                        ATOM  1485                                                                              CD2 TYR                                                                               248                                                                               28.120                                                                             18.059                                                                             8.700                                                                              1.00                                                                              17.91                                        ATOM  1486                                                                              CE2 TYR                                                                               248                                                                               27.883                                                                             19.376                                                                             8.354                                                                              1.00                                                                              15.27                                        ATOM  1487                                                                              CZ  TYR                                                                               248                                                                               28.037                                                                             20.369                                                                             9.299                                                                              1.00                                                                              17.78                                        ATOM  1488                                                                              OH  TYR                                                                               248                                                                               27.793                                                                             21.684                                                                             8.965                                                                              1.00                                                                              25.83                                        ATOM  1489                                                                              C   TYR                                                                               248                                                                               26.158                                                                             16.041                                                                             10.611                                                                             1.00                                                                              20.61                                        ATOM  1490                                                                              O   TYR                                                                               248                                                                               25.378                                                                             16.842                                                                             11.111                                                                             1.00                                                                              22.05                                        ATOM  1491                                                                              N   ASN                                                                               249                                                                               25.892                                                                             15.369                                                                             9.500                                                                              1.00                                                                              23.02                                        ATOM  1492                                                                              CA  ASN                                                                               249                                                                               24.664                                                                             15.626                                                                             8.778                                                                              1.00                                                                              23.67                                        ATOM  1493                                                                              CB  ASN                                                                               249                                                                               24.597                                                                             14.835                                                                             7.483                                                                              1.00                                                                              21.11                                        ATOM  1494                                                                              CG  ASN                                                                               249                                                                               25.513                                                                             15.393                                                                             6.422                                                                              1.00                                                                              22.16                                        ATOM  1495                                                                              OD1 ASN                                                                               249                                                                               25.870                                                                             16.560                                                                             6.461                                                                              1.00                                                                              29.65                                        ATOM  1496                                                                              ND2 ASN                                                                               249                                                                               25.918                                                                             14.556                                                                             5.478                                                                              1.00                                                                              23.60                                        ATOM  1497                                                                              C   ASN                                                                               249                                                                               23.490                                                                             15.315                                                                             9.655                                                                              1.00                                                                              25.98                                        ATOM  1498                                                                              O   ASN                                                                               249                                                                               22.552                                                                             16.119                                                                             9.737                                                                              1.00                                                                              28.81                                        ATOM  1499                                                                              N   VAL                                                                               250                                                                               23.581                                                                             14.197                                                                             10.378                                                                             1.00                                                                              25.43                                        ATOM  1500                                                                              CA  VAL                                                                               250                                                                               22.507                                                                             13.792                                                                             11.270                                                                             1.00                                                                              23.20                                        ATOM  1501                                                                              CB  VAL                                                                               250                                                                               22.777                                                                             12.430                                                                             11.913                                                                             1.00                                                                              22.17                                        ATOM  1502                                                                              CG1 VAL                                                                               250                                                                               21.826                                                                             12.188                                                                             13.069                                                                             1.00                                                                              17.43                                        ATOM  1503                                                                              CG2 VAL                                                                               250                                                                               22.594                                                                             11.343                                                                             10.894                                                                             1.00                                                                              18.80                                        ATOM  1504                                                                              C   VAL                                                                               250                                                                               22.247                                                                             14.833                                                                             12.345                                                                             1.00                                                                              25.76                                        ATOM  1505                                                                              O   VAL                                                                               250                                                                               21.101                                                                             15.166                                                                             12.599                                                                             1.00                                                                              34.35                                        ATOM  1506                                                                              N   GLY                                                                               251                                                                               23.292                                                                             15.373                                                                             12.955                                                                             1.00                                                                              24.96                                        ATOM  1507                                                                              CA  GLY                                                                               251                                                                               23.092                                                                             16.373                                                                             13.986                                                                             1.00                                                                              23.97                                        ATOM  1508                                                                              C   GLY                                                                               251                                                                               22.657                                                                             17.701                                                                             13.402                                                                             1.00                                                                              28.06                                        ATOM  1509                                                                              O   GLY                                                                               251                                                                               21.793                                                                             18.396                                                                             13.947                                                                             1.00                                                                              31.01                                        ATOM  1510                                                                              N   LEU                                                                               252                                                                               23.273                                                                             18.070                                                                             12.290                                                                             1.00                                                                              29.10                                        ATOM  1511                                                                              CA  LEU                                                                               252                                                                               22.957                                                                             19.321                                                                             11.628                                                                             1.00                                                                              28.66                                        ATOM  1512                                                                              CB  LEU                                                                               252                                                                               23.704                                                                             19.424                                                                             10.309                                                                             1.00                                                                              23.77                                        ATOM  1513                                                                              CG  LEU                                                                               252                                                                               23.320                                                                             20.699                                                                             9.575                                                                              1.00                                                                              22.56                                        ATOM  1514                                                                              CD1 LEU                                                                               252                                                                               23.869                                                                             21.892                                                                             10.323                                                                             1.00                                                                              26.59                                        ATOM  1515                                                                              CD2 LEU                                                                               252                                                                               23.816                                                                             20.672                                                                             8.152                                                                              1.00                                                                              24.48                                        ATOM  1516                                                                              C   LEU                                                                               252                                                                               21.474                                                                             19.391                                                                             11.342                                                                             1.00                                                                              30.41                                        ATOM  1517                                                                              O   LEU                                                                               252                                                                               20.801                                                                             20.344                                                                             11.716                                                                             1.00                                                                              32.91                                        ATOM  1518                                                                              N   ASN                                                                               253                                                                               20.966                                                                             18.347                                                                             10.711                                                                             1.00                                                                              30.60                                        ATOM  1519                                                                              CA  ASN                                                                               253                                                                               19.569                                                                             18.295                                                                             10.351                                                                             1.00                                                                              33.65                                        ATOM  1520                                                                              CB  ASN                                                                               253                                                                               19.316                                                                             17.160                                                                             9.372                                                                              1.00                                                                              35.63                                        ATOM  1521                                                                              CG  ASN                                                                               253                                                                               19.862                                                                             17.463                                                                             7.994                                                                              1.00                                                                              42.54                                        ATOM  1522                                                                              OD1 ASN                                                                               253                                                                               20.855                                                                             18.186                                                                             7.835                                                                              1.00                                                                              42.40                                        ATOM  1523                                                                              ND2 ASN                                                                               253                                                                               19.203                                                                             16.930                                                                             6.981                                                                              1.00                                                                              50.55                                        ATOM  1524                                                                              C   ASN                                                                               253                                                                               18.599                                                                             18.235                                                                             11.507                                                                             1.00                                                                              33.58                                        ATOM  1525                                                                              O   ASN                                                                               253                                                                               17.414                                                                             18.515                                                                             11.336                                                                             1.00                                                                              37.79                                        ATOM  1526                                                                              N   GLY                                                                               254                                                                               19.085                                                                             17.900                                                                             12.693                                                                             1.00                                                                              31.74                                        ATOM  1527                                                                              CA  GLY                                                                               254                                                                               18.189                                                                             17.842                                                                             13.839                                                                             1.00                                                                              29.82                                        ATOM  1528                                                                              C   GLY                                                                               254                                                                               17.844                                                                             19.241                                                                             14.310                                                                             1.00                                                                              29.07                                        ATOM  1529                                                                              O   GLY                                                                               254                                                                               16.876                                                                             19.454                                                                             15.024                                                                             1.00                                                                              29.77                                        ATOM  1530                                                                              N   LEU                                                                               255                                                                               18.645                                                                             20.208                                                                             13.885                                                                             1.00                                                                              28.00                                        ATOM  1531                                                                              CA  LEU                                                                               255                                                                               18.448                                                                             21.586                                                                             14.269                                                                             1.00                                                                              26.04                                        ATOM  1532                                                                              CB  LEU                                                                               255                                                                               19.804                                                                             22.200                                                                             14.577                                                                             1.00                                                                              22.14                                        ATOM  1533                                                                              CG  LEU                                                                               255                                                                               20.563                                                                             21.304                                                                             15.563                                                                             1.00                                                                              27.96                                        ATOM  1534                                                                              CD1 LEU                                                                               255                                                                               22.068                                                                             21.563                                                                             15.626                                                                             1.00                                                                              26.56                                        ATOM  1535                                                                              CD2 LEU                                                                               255                                                                               19.938                                                                             21.483                                                                             16.905                                                                             1.00                                                                              27.86                                        ATOM  1536                                                                              C   LEU                                                                               255                                                                               17.687                                                                             22.391                                                                             13.209                                                                             1.00                                                                              30.33                                        ATOM  1537                                                                              O   LEU                                                                               255                                                                               17.556                                                                             23.608                                                                             13.330                                                                             1.00                                                                              35.36                                        ATOM  1538                                                                              N   ARG                                                                               256                                                                               17.187                                                                             21.726                                                                             12.169                                                                             1.00                                                                              31.16                                        ATOM  1539                                                                              CA  ARG                                                                               256                                                                               16.436                                                                             22.438                                                                             11.145                                                                             1.00                                                                              32.82                                        ATOM  1540                                                                              CB  ARG                                                                               256                                                                               16.244                                                                             21.610                                                                             9.865                                                                              1.00                                                                              31.47                                        ATOM  1541                                                                              CG  ARG                                                                               256                                                                               17.508                                                                             21.568                                                                             9.000                                                                              1.00                                                                              35.00                                        ATOM  1542                                                                              CD  ARG                                                                               256                                                                               17.291                                                                             21.321                                                                             7.501                                                                              1.00                                                                              30.02                                        ATOM  1543                                                                              NE  ARG                                                                               256                                                                               18.344                                                                             22.019                                                                             6.759                                                                              1.00                                                                              34.65                                        ATOM  1544                                                                              CZ  ARG                                                                               256                                                                               19.515                                                                             21.489                                                                             6.394                                                                              1.00                                                                              40.31                                        ATOM  1545                                                                              NH1 ARG                                                                               256                                                                               20.404                                                                             22.236                                                                             5.758                                                                              1.00                                                                              47.05                                        ATOM  1546                                                                              NH2 ARG                                                                               256                                                                               19.788                                                                             20.205                                                                             6.587                                                                              1.00                                                                              44.05                                        ATOM  1547                                                                              C   ARG                                                                               256                                                                               15.106                                                                             22.738                                                                             11.775                                                                             1.00                                                                              36.39                                        ATOM  1548                                                                              O   ARG                                                                               256                                                                               14.455                                                                             21.844                                                                             12.325                                                                             1.00                                                                              39.88                                        ATOM  1549                                                                              N   GLY                                                                               257                                                                               14.772                                                                             24.020                                                                             11.792                                                                             1.00                                                                              37.32                                        ATOM  1550                                                                              CA  GLY                                                                               257                                                                               13.522                                                                             24.492                                                                             12.359                                                                             1.00                                                                              37.66                                        ATOM  1551                                                                              C   GLY                                                                               257                                                                               13.120                                                                             25.647                                                                             11.475                                                                             1.00                                                                              39.38                                        ATOM  1552                                                                              O   GLY                                                                               257                                                                               13.795                                                                             25.892                                                                             10.466                                                                             1.00                                                                              45.14                                        ATOM  1553                                                                              N   SER                                                                               258                                                                               12.069                                                                             26.377                                                                             11.830                                                                             1.00                                                                              39.54                                        ATOM  1554                                                                              CA  SER                                                                               258                                                                               11.625                                                                             27.496                                                                             10.989                                                                             1.00                                                                              40.17                                        ATOM  1555                                                                              CB  SER                                                                               258                                                                               10.131                                                                             27.380                                                                             10.721                                                                             1.00                                                                              39.14                                        ATOM  1556                                                                              OG  SER                                                                               258                                                                               9.461                                                                              27.094                                                                             11.930                                                                             1.00                                                                              43.54                                        ATOM  1557                                                                              C   SER                                                                               258                                                                               11.921                                                                             28.885                                                                             11.518                                                                             1.00                                                                              37.11                                        ATOM  1558                                                                              O   SER                                                                               258                                                                               11.872                                                                             29.862                                                                             10.779                                                                             1.00                                                                              35.66                                        ATOM  1559                                                                              N   THR                                                                               259                                                                               12.259                                                                             28.957                                                                             12.790                                                                             1.00                                                                              37.79                                        ATOM  1560                                                                              CA  THR                                                                               259                                                                               12.518                                                                             30.215                                                                             13.455                                                                             1.00                                                                              41.44                                        ATOM  1561                                                                              CB  THR                                                                               259                                                                               12.301                                                                             30.043                                                                             14.951                                                                             1.00                                                                              45.91                                        ATOM  1562                                                                              OG1 THR                                                                               259                                                                               11.504                                                                             28.874                                                                             15.180                                                                             1.00                                                                              55.55                                        ATOM  1563                                                                              CG2 THR                                                                               259                                                                               11.600                                                                             31.273                                                                             15.530                                                                             1.00                                                                              55.48                                        ATOM  1564                                                                              C   THR                                                                               259                                                                               13.899                                                                             30.826                                                                             13.285                                                                             1.00                                                                              38.35                                        ATOM  1565                                                                              O   THR                                                                               259                                                                               14.813                                                                             30.213                                                                             12.739                                                                             1.00                                                                              41.82                                        ATOM  1566                                                                              N   TYR                                                                               260                                                                               14.020                                                                             32.057                                                                             13.771                                                                             1.00                                                                              35.05                                        ATOM  1567                                                                              CA  TYR                                                                               260                                                                               15.269                                                                             32.786                                                                             13.777                                                                             1.00                                                                              31.66                                        ATOM  1568                                                                              CB  TYR                                                                               260                                                                               15.049                                                                             34.194                                                                             14.305                                                                             1.00                                                                              26.91                                        ATOM  1569                                                                              CG  TYR                                                                               260                                                                               16.340                                                                             34.934                                                                             14.460                                                                             1.00                                                                              26.27                                        ATOM  1570                                                                              CD1 TYR                                                                               260                                                                               16.998                                                                             35.438                                                                             13.349                                                                             1.00                                                                              28.25                                        ATOM  1571                                                                              CE1 TYR                                                                               260                                                                               18.205                                                                             36.077                                                                             13.463                                                                             1.00                                                                              26.96                                        ATOM  1572                                                                              CD2 TYR                                                                               260                                                                               16.933                                                                             35.097                                                                             15.702                                                                             1.00                                                                              28.45                                        ATOM  1573                                                                              CE2 TYR                                                                               260                                                                               18.152                                                                             35.740                                                                             15.828                                                                             1.00                                                                              26.78                                        ATOM  1574                                                                              CZ  TYR                                                                               260                                                                               18.770                                                                             36.224                                                                             14.696                                                                             1.00                                                                              27.71                                        ATOM  1575                                                                              OH  TYR                                                                               260                                                                               19.957                                                                             36.878                                                                             14.774                                                                             1.00                                                                              36.80                                        ATOM  1576                                                                              C   TYR                                                                               260                                                                               16.160                                                                             32.065                                                                             14.773                                                                             1.00                                                                              34.78                                        ATOM  1577                                                                              O   TYR                                                                               260                                                                               17.357                                                                             31.917                                                                             14.557                                                                             1.00                                                                              37.21                                        ATOM  1578                                                                              N   ASP                                                                               261                                                                               15.566                                                                             31.656                                                                             15.891                                                                             1.00                                                                              37.42                                        ATOM  1579                                                                              CA  ASP                                                                               261                                                                               16.295                                                                             30.961                                                                             16.942                                                                             1.00                                                                              40.44                                        ATOM  1580                                                                              CB  ASP                                                                               261                                                                               15.413                                                                             30.745                                                                             18.165                                                                             1.00                                                                              46.19                                        ATOM  1581                                                                              CG  ASP                                                                               261                                                                               16.204                                                                             30.322                                                                             19.386                                                                             1.00                                                                              52.07                                        ATOM  1582                                                                              OD1 ASP                                                                               261                                                                               17.336                                                                             30.836                                                                             19.573                                                                             1.00                                                                              55.53                                        ATOM  1583                                                                              OD2 ASP                                                                               261                                                                               15.692                                                                             29.482                                                                             20.159                                                                             1.00                                                                              54.28                                        ATOM  1584                                                                              C   ASP                                                                               261                                                                               16.734                                                                             29.626                                                                             16.411                                                                             1.00                                                                              40.15                                        ATOM  1585                                                                              O   ASP                                                                               261                                                                               17.863                                                                             29.195                                                                             16.644                                                                             1.00                                                                              40.37                                        ATOM  1586                                                                              N   ALA                                                                               262                                                                               15.823                                                                             28.974                                                                             15.697                                                                             1.00                                                                              40.43                                        ATOM  1587                                                                              CA  ALA                                                                               262                                                                               16.113                                                                             27.679                                                                             15.104                                                                             1.00                                                                              39.06                                        ATOM  1588                                                                              CB  ALA                                                                               262                                                                               14.936                                                                             27.183                                                                             14.297                                                                             1.00                                                                              36.99                                        ATOM  1589                                                                              C   ALA                                                                               262                                                                               17.324                                                                             27.863                                                                             14.209                                                                             1.00                                                                              38.56                                        ATOM  1590                                                                              O   ALA                                                                               262                                                                               18.222                                                                             27.031                                                                             14.213                                                                             1.00                                                                              42.67                                        ATOM  1591                                                                              N   TRP                                                                               263                                                                               17.372                                                                             28.972                                                                             13.475                                                                             1.00                                                                              34.48                                        ATOM  1592                                                                              CA  TRP                                                                               263                                                                               18.501                                                                             29.200                                                                             12.612                                                                             1.00                                                                              30.51                                        ATOM  1593                                                                              CB  TRP                                                                               263                                                                               18.254                                                                             30.341                                                                             11.647                                                                             1.00                                                                              29.10                                        ATOM  1594                                                                              CG  TRP                                                                               263                                                                               19.279                                                                             30.344                                                                             10.580                                                                             1.00                                                                              27.55                                        ATOM  1595                                                                              CD2 TRP                                                                               263                                                                               20.493                                                                             31.087                                                                             10.566                                                                             1.00                                                                              26.16                                        ATOM  1596                                                                              CE2 TRP                                                                               263                                                                               21.195                                                                             30.722                                                                             9.389                                                                              1.00                                                                              27.70                                        ATOM  1597                                                                              CE3 TRP                                                                               263                                                                               21.063                                                                             32.022                                                                             11.434                                                                             1.00                                                                              25.40                                        ATOM  1598                                                                              CD1 TRP                                                                               263                                                                               19.281                                                                             29.586                                                                             9.447                                                                              1.00                                                                              30.08                                        ATOM  1599                                                                              NE1 TRP                                                                               263                                                                               20.429                                                                             29.803                                                                             8.727                                                                              1.00                                                                              25.78                                        ATOM  1600                                                                              CZ2 TRP                                                                               263                                                                               22.441                                                                             31.264                                                                             9.050                                                                              1.00                                                                              26.88                                        ATOM  1601                                                                              CZ3 TRP                                                                               263                                                                               22.307                                                                             32.565                                                                             11.105                                                                             1.00                                                                              32.51                                        ATOM  1602                                                                              CH2 TRP                                                                               263                                                                               22.986                                                                             32.178                                                                             9.912                                                                              1.00                                                                              33.60                                        ATOM  1603                                                                              C   TRP                                                                               263                                                                               19.800                                                                             29.438                                                                             13.373                                                                             1.00                                                                              31.82                                        ATOM  1604                                                                              O   TRP                                                                               263                                                                               20.761                                                                             28.703                                                                             13.176                                                                             1.00                                                                              33.27                                        ATOM  1605                                                                              N   VAL                                                                               264                                                                               19.838                                                                             30.415                                                                             14.269                                                                             1.00                                                                              29.96                                        ATOM  1606                                                                              CA  VAL                                                                               264                                                                               21.088                                                                             30.704                                                                             14.981                                                                             1.00                                                                              33.08                                        ATOM  1607                                                                              CB  VAL                                                                               264                                                                               20.955                                                                             31.885                                                                             15.992                                                                             1.00                                                                              35.92                                        ATOM  1608                                                                              CG1 VAL                                                                               264                                                                               20.488                                                                             33.142                                                                             15.272                                                                             1.00                                                                              35.34                                        ATOM  1609                                                                              CG2 VAL                                                                               264                                                                               19.991                                                                             31.534                                                                             17.130                                                                             1.00                                                                              40.92                                        ATOM  1610                                                                              C   VAL                                                                               264                                                                               21.726                                                                             29.488                                                                             15.651                                                                             1.00                                                                              33.22                                        ATOM  1611                                                                              O   VAL                                                                               264                                                                               22.948                                                                             29.417                                                                             15.762                                                                             1.00                                                                              33.90                                        ATOM  1612                                                                              N   LYS                                                                               265                                                                               20.907                                                                             28.521                                                                             16.059                                                                             1.00                                                                              33.23                                        ATOM  1613                                                                              CA  LYS                                                                               265                                                                               21.414                                                                             27.303                                                                             16.697                                                                             1.00                                                                              34.85                                        ATOM  1614                                                                              CB  LYS                                                                               265                                                                               20.343                                                                             26.643                                                                             17.564                                                                             1.00                                                                              37.37                                        ATOM  1615                                                                              CG  LYS                                                                               265                                                                               20.023                                                                             27.416                                                                             18.819                                                                             1.00                                                                              44.29                                        ATOM  1616                                                                              CD  LYS                                                                               265                                                                               19.068                                                                             26.626                                                                             19.676                                                                             1.00                                                                              55.75                                        ATOM  1617                                                                              CE  LYS                                                                               265                                                                               18.503                                                                             27.475                                                                             20.813                                                                             1.00                                                                              63.56                                        ATOM  1618                                                                              NZ  LYS                                                                               265                                                                               17.404                                                                             26.772                                                                             21.560                                                                             1.00                                                                              68.84                                        ATOM  1619                                                                              C   LYS                                                                               265                                                                               21.912                                                                             26.317                                                                             15.652                                                                             1.00                                                                              32.74                                        ATOM  1620                                                                              O   LYS                                                                               265                                                                               22.906                                                                             25.631                                                                             15.855                                                                             1.00                                                                              31.29                                        ATOM  1621                                                                              N   PHE                                                                               266                                                                               21.189                                                                             26.259                                                                             14.545                                                                             1.00                                                                              30.50                                        ATOM  1622                                                                              CA  PHE                                                                               266                                                                               21.515                                                                             25.422                                                                             13.411                                                                             1.00                                                                              27.65                                        ATOM  1623                                                                              CB  PHE                                                                               266                                                                               20.411                                                                             25.601                                                                             12.373                                                                             1.00                                                                              23.05                                        ATOM  1624                                                                              CG  PHE                                                                               266                                                                               20.742                                                                             25.066                                                                             11.028                                                                             1.00                                                                              26.10                                        ATOM  1625                                                                              CD1 PHE                                                                               266                                                                               20.494                                                                             23.727                                                                             10.714                                                                             1.00                                                                              23.77                                        ATOM  1626                                                                              CD2 PHE                                                                               266                                                                               21.253                                                                             25.915                                                                             16.036                                                                             1.00                                                                              27.75                                        ATOM  1627                                                                              CE1 PHE                                                                               266                                                                               20.746                                                                             23.235                                                                             9.426                                                                              1.00                                                                              20.79                                        ATOM  1628                                                                              CE2 PHE                                                                               266                                                                               21.506                                                                             25.434                                                                             8.748                                                                              1.00                                                                              25.12                                        ATOM  1629                                                                              CZ  PHE                                                                               266                                                                               21.247                                                                             24.079                                                                             8.447                                                                              1.00                                                                              20.14                                        ATOM  1630                                                                              C   PHE                                                                               266                                                                               22.868                                                                             25.865                                                                             12.843                                                                             1.00                                                                              28.95                                        ATOM  1631                                                                              O   PHE                                                                               266                                                                               23.705                                                                             25.034                                                                             12.494                                                                             1.00                                                                              33.21                                        ATOM  1632                                                                              N   ASN                                                                               267                                                                               23.080                                                                             27.177                                                                             12.769                                                                             1.00                                                                              27.02                                        ATOM  1633                                                                              CA  ASN                                                                               267                                                                               24.323                                                                             27.716                                                                             12.244                                                                             1.00                                                                              26.43                                        ATOM  1634                                                                              CB  ASN                                                                               267                                                                               24.175                                                                             29.175                                                                             11.812                                                                             1.00                                                                              25.78                                        ATOM  1635                                                                              CG  ASN                                                                               267                                                                               25.484                                                                             29.752                                                                             11.261                                                                             1.00                                                                              30.92                                        ATOM  1636                                                                              OD1 ASN                                                                               267                                                                               25.979                                                                             29.315                                                                             10.216                                                                             1.00                                                                              34.66                                        ATOM  1637                                                                              ND2 ASN                                                                               267                                                                               26.061                                                                             30.707                                                                             11.975                                                                             1.00                                                                              31.20                                        ATOM  1638                                                                              C   ASN                                                                               267                                                                               25.497                                                                             27.609                                                                             13.197                                                                             1.00                                                                              28.55                                        ATOM  1639                                                                              O   ASN                                                                               267                                                                               26.640                                                                             27.638                                                                             12.760                                                                             1.00                                                                              35.77                                        ATOM  1640                                                                              N   ARG                                                                               268                                                                               25.246                                                                             27.537                                                                             14.498                                                                             1.00                                                                              30.56                                        ATOM  1641                                                                              CA  ARG                                                                               268                                                                               26.345                                                                             27.433                                                                             15.452                                                                             1.00                                                                              26.63                                        ATOM  1642                                                                              CB  ARG                                                                               268                                                                               25.851                                                                             27.773                                                                             16.844                                                                             1.00                                                                              31.27                                        ATOM  1643                                                                              CG  ARG                                                                               268                                                                               26.959                                                                             28.125                                                                             17.764                                                                             1.00                                                                              42.83                                        ATOM  1644                                                                              CD  ARG                                                                               268                                                                               26.452                                                                             28.417                                                                             19.139                                                                             1.00                                                                              52.31                                        ATOM  1645                                                                              NE  ARG                                                                               268                                                                               27.563                                                                             28.446                                                                             20.076                                                                             1.00                                                                              61.73                                        ATOM  1646                                                                              CZ  ARG                                                                               268                                                                               27.510                                                                             27.929                                                                             21.295                                                                             1.00                                                                              68.05                                        ATOM  1647                                                                              NH1 ARG                                                                               268                                                                               28.574                                                                             27.980                                                                             22.086                                                                             1.00                                                                              71.21                                        ATOM  1648                                                                              NH2 ARG                                                                               268                                                                               26.382                                                                             27.374                                                                             21.725                                                                             1.00                                                                              75.05                                        ATOM  1649                                                                              C   ARG                                                                               268                                                                               26.955                                                                             26.028                                                                             15.407                                                                             1.00                                                                              25.08                                        ATOM  1650                                                                              O   ARG                                                                               268                                                                               28.157                                                                             25.861                                                                             15.470                                                                             1.00                                                                              24.26                                        ATOM  1651                                                                              N   PHE                                                                               269                                                                               26.106                                                                             25.020                                                                             15.284                                                                             1.00                                                                              21.54                                        ATOM  1652                                                                              CA  PHE                                                                               269                                                                               26.547                                                                             23.645                                                                             15.194                                                                             1.00                                                                              20.29                                        ATOM  1653                                                                              CB  PHE                                                                               269                                                                               25.315                                                                             22.731                                                                             15.080                                                                             1.00                                                                              17.88                                        ATOM  1654                                                                              CG  PHE                                                                               269                                                                               25.631                                                                             21.252                                                                             14.947                                                                             1.00                                                                              23.71                                        ATOM  1655                                                                              CD1 PHE                                                                               269                                                                               25.620                                                                             20.419                                                                             16.063                                                                             1.00                                                                              22.41                                        ATOM  1656                                                                              CD2 PHE                                                                               269                                                                               25.870                                                                             20.677                                                                             13.691                                                                             1.00                                                                              25.94                                        ATOM  1657                                                                              CE1 PHE                                                                               269                                                                               25.838                                                                             19.062                                                                             15.937                                                                             1.00                                                                              20.65                                        ATOM  1658                                                                              CE2 PHE                                                                               269                                                                               26.091                                                                             19.315                                                                             13.552                                                                             1.00                                                                              17.14                                        ATOM  1659                                                                              CZ  PHE                                                                               269                                                                               26.071                                                                             18.509                                                                             14.679                                                                             1.00                                                                              25.30                                        ATOM  1660                                                                              C   PHE                                                                               269                                                                               27.361                                                                             23.588                                                                             13.917                                                                             1.00                                                                              22.39                                        ATOM  1661                                                                              O   PHE                                                                               269                                                                               28.492                                                                             23.108                                                                             13.910                                                                             1.00                                                                              22.31                                        ATOM  1662                                                                              N   ARG                                                                               270                                                                               26.794                                                                             24.133                                                                             12.841                                                                             1.00                                                                              24.10                                        ATOM  1663                                                                              CA  ARG                                                                               270                                                                               27.461                                                                             24.132                                                                             11.547                                                                             1.00                                                                              22.53                                        ATOM  1664                                                                              CB  ARG                                                                               270                                                                               26.638                                                                             24.864                                                                             10.482                                                                             1.00                                                                              21.20                                        ATOM  1665                                                                              CG  ARG                                                                               270                                                                               27.412                                                                             25.170                                                                             9.196                                                                              1.00                                                                              17.05                                        ATOM  1666                                                                              CD  ARG                                                                               270                                                                               26.472                                                                             25.476                                                                             8.036                                                                              1.00                                                                              20.10                                        ATOM  1667                                                                              NE  ARG                                                                               270                                                                               25.772                                                                             26.749                                                                             8.190                                                                              1.00                                                                              24.43                                        ATOM  1668                                                                              CZ  ARG                                                                               270                                                                               24.661                                                                             27.094                                                                             7.541                                                                              1.00                                                                              19.92                                        ATOM  1669                                                                              NH1 ARG                                                                               270                                                                               24.131                                                                             28.286                                                                             7.754                                                                              1.00                                                                              16.84                                        ATOM  1670                                                                              NH2 ARG                                                                               270                                                                               24.069                                                                             26.257                                                                             6.695                                                                              1.00                                                                              18.36                                        ATOM  1671                                                                              C   ARG                                                                               270                                                                               28.839                                                                             24.730                                                                             11.667                                                                             1.00                                                                              21.46                                        ATOM  1672                                                                              O   ARG                                                                               270                                                                               29.810                                                                             24.131                                                                             11.230                                                                             1.00                                                                              25.30                                        ATOM  1673                                                                              N   ARG                                                                               271                                                                               28.943                                                                             25.893                                                                             12.286                                                                             1.00                                                                              24.12                                        ATOM  1674                                                                              CA  ARG                                                                               271                                                                               30.258                                                                             26.509                                                                             12.435                                                                             1.00                                                                              27.33                                        ATOM  1675                                                                              CB  ARG                                                                               271                                                                               30.155                                                                             27.931                                                                             13.0G5                                                                             1.00                                                                              23.38                                        ATOM  1676                                                                              CG  ARG                                                                               271                                                                               31.492                                                                             28.628                                                                             13.101                                                                             1.00                                                                              19.25                                        ATOM  1677                                                                              CD  ARG                                                                               271                                                                               31.372                                                                             30.006                                                                             13.673                                                                             1.00                                                                              15.09                                        ATOM  1678                                                                              NE  ARG                                                                               271                                                                               30.776                                                                             30.008                                                                             15.006                                                                             1.00                                                                              23.57                                        ATOM  1679                                                                              CZ  ARG                                                                               271                                                                               29.518                                                                             30.367                                                                             15.281                                                                             1.00                                                                              24.60                                        ATOM  1680                                                                              NH1 ARG                                                                               271                                                                               28.683                                                                             30.753                                                                             14.326                                                                             1.00                                                                              23.54                                        ATOM  1681                                                                              NH2 ARG                                                                               271                                                                               29.095                                                                             30.371                                                                             16.531                                                                             1.00                                                                              27.57                                        ATOM  1682                                                                              C   ARG                                                                               271                                                                               31.177                                                                             25.654                                                                             13.306                                                                             1.00                                                                              27.87                                        ATOM  1683                                                                              O   ARG                                                                               271                                                                               32.185                                                                             25.115                                                                             12.827                                                                             1.00                                                                              32.35                                        ATOM  1684                                                                              N   GLU                                                                               272                                                                               30.812                                                                             25.516                                                                             14.574                                                                             1.00                                                                              25.58                                        ATOM  1685                                                                              CA  GLU                                                                               272                                                                               31.603                                                                             24.761                                                                             15.525                                                                             1.00                                                                              23.38                                        ATOM  1686                                                                              CB  GLU                                                                               272                                                                               30.882                                                                             24.679                                                                             16.864                                                                             1.00                                                                              21.26                                        ATOM  1687                                                                              CG  GLU                                                                               272                                                                               30.754                                                                             26.023                                                                             17.597                                                                             1.00                                                                              24.09                                        ATOM  1688                                                                              CD  GLU                                                                               272                                                                               30.583                                                                             25.877                                                                             19.126                                                                             1.00                                                                              28.18                                        ATOM  1689                                                                              OE1 GLU                                                                               272                                                                               30.578                                                                             24.731                                                                             19.638                                                                             1.00                                                                              27.43                                        ATOM  1690                                                                              OE2 GLU                                                                               272                                                                               30.475                                                                             26.912                                                                             19.826                                                                             1.00                                                                              22.15                                        ATOM  1691                                                                              C   GLU                                                                               272                                                                               32.041                                                                             23.376                                                                             15.044                                                                             1.00                                                                              24.71                                        ATOM  1692                                                                              O   GLU                                                                               272                                                                               33.213                                                                             23.038                                                                             15.171                                                                             1.00                                                                              29.53                                        ATOM  1693                                                                              N   MET                                                                               273                                                                               31.152                                                                             22.600                                                                             14.425                                                                             1.00                                                                              24.06                                        ATOM  1694                                                                              CA  MET                                                                               273                                                                               31.550                                                                             21.267                                                                             13.963                                                                             1.00                                                                              21.72                                        ATOM  1695                                                                              CB  MET                                                                               273                                                                               30.346                                                                             20.369                                                                             13.702                                                                             1.00                                                                              18.83                                        ATOM  1696                                                                              CG  MET                                                                               273                                                                               29.513                                                                             20.153                                                                             14.957                                                                             1.00                                                                              25.80                                        ATOM  1697                                                                              SD  MET                                                                               273                                                                               30.469                                                                             19.573                                                                             16.380                                                                             1.00                                                                              26.36                                        ATOM  1698                                                                              CE  MET                                                                               273                                                                               30.020                                                                             18.024                                                                             16.296                                                                             1.00                                                                              25.30                                        ATOM  1699                                                                              C   MET                                                                               273                                                                               32.486                                                                             21.291                                                                             12.766                                                                             1.00                                                                              19.58                                        ATOM  1700                                                                              O   MET                                                                               273                                                                               33.248                                                                             20.352                                                                             12.542                                                                             1.00                                                                              22.39                                        ATOM  1701                                                                              N   THR                                                                               274                                                                               32.444                                                                             22.367                                                                             12.001                                                                             1.00                                                                              20.73                                        ATOM  1702                                                                              CA  THR                                                                               274                                                                               33.326                                                                             22.506                                                                             10.857                                                                             1.00                                                                              20.99                                        ATOM  1703                                                                              CB  THR                                                                               214                                                                               32.921                                                                             23.696                                                                             9.929                                                                              1.00                                                                              23.08                                        ATOM  1704                                                                              OG1 THR                                                                               274                                                                               31.617                                                                             23.470                                                                             9.369                                                                              1.00                                                                              16.49                                        ATOM  1705                                                                              CG2 THR                                                                               274                                                                               33.934                                                                             23.835                                                                             8.788                                                                              1.00                                                                              21.44                                        ATOM  1706                                                                              C   THR                                                                               274                                                                               34.730                                                                             22.765                                                                             11.395                                                                             1.00                                                                              23.86                                        ATOM  1707                                                                              O   THR                                                                               274                                                                               35.666                                                                             22.034                                                                             11.055                                                                             1.00                                                                              25.97                                        ATOM  1708                                                                              N   LEU                                                                               275                                                                               34.869                                                                             23.779                                                                             12.251                                                                             1.00                                                                              21.98                                        ATOM  1709                                                                              CA  LEU                                                                               275                                                                               36.175                                                                             24.142                                                                             12.813                                                                             1.00                                                                              20.62                                        ATOM  1710                                                                              CB  LEU                                                                               275                                                                               36.035                                                                             25.349                                                                             13.741                                                                             1.00                                                                              17.97                                        ATOM  1711                                                                              CG  LEU                                                                               275                                                                               35.412                                                                             26.626                                                                             13.158                                                                             1.00                                                                              20.11                                        ATOM  1712                                                                              CD1 LEU                                                                               275                                                                               35.130                                                                             27.603                                                                             14.269                                                                             1.00                                                                              15.23                                        ATOM  1713                                                                              CD2 LEU                                                                               275                                                                               36.304                                                                             27.264                                                                             12.143                                                                             1.00                                                                              15.87                                        ATOM  1714                                                                              C   LEU                                                                               275                                                                               36.845                                                                             22.996                                                                             13.584                                                                             1.00                                                                              21.58                                        ATOM  1715                                                                              O   LEU                                                                               275                                                                               38.058                                                                             22.839                                                                             13.539                                                                             1.00                                                                              19.28                                        ATOM  1716                                                                              N   THR                                                                               276                                                                               36.029                                                                             22.168                                                                             14.226                                                                             1.00                                                                              21.92                                        ATOM  1717                                                                              CA  THR                                                                               276                                                                               36.489                                                                             21.067                                                                             15.050                                                                             1.00                                                                              20.54                                        ATOM  1718                                                                              CB  THR                                                                               276                                                                               35.589                                                                             20.941                                                                             16.302                                                                             1.00                                                                              20.03                                        ATOM  1719                                                                              OG1 THR                                                                               276                                                                               35.488                                                                             22.205                                                                             16.964                                                                             1.00                                                                              27.51                                        ATOM  1720                                                                              CG2 THR                                                                               276                                                                               36.174                                                                             19.971                                                                             17.264                                                                             1.00                                                                              27.26                                        ATOM  1721                                                                              C   THR                                                                               276                                                                               36.545                                                                             19.692                                                                             14.413                                                                             1.00                                                                              18.29                                        ATOM  1722                                                                              O   THR                                                                               276                                                                               37.294                                                                             18.850                                                                             14.864                                                                             1.00                                                                              24.41                                        ATOM  1723                                                                              N   VAL                                                                               277                                                                               35.728                                                                             19.424                                                                             13.411                                                                             1.00                                                                              18.63                                        ATOM  1724                                                                              CA  VAL                                                                               277                                                                               35.738                                                                             18.103                                                                             12.819                                                                             1.00                                                                              17.30                                        ATOM  1725                                                                              CB  VAL                                                                               277                                                                               34.433                                                                             17.375                                                                             13.124                                                                             1.00                                                                              18.32                                        ATOM  1726                                                                              CG1 VAL                                                                               277                                                                               34.492                                                                             15.951                                                                             12.616                                                                             1.00                                                                              15.85                                        ATOM  1727                                                                              CG2 VAL                                                                               277                                                                               34.166                                                                             17.401                                                                             14.605                                                                             1.00                                                                              13.45                                        ATOM  1728                                                                              C   VAL                                                                               277                                                                               35.974                                                                             18.079                                                                             11.313                                                                             1.00                                                                              24.98                                        ATOM  1729                                                                              O   VAL                                                                               277                                                                               36.990                                                                             17.559                                                                             10.832                                                                             1.00                                                                              29.29                                        ATOM  1730                                                                              N   LEU                                                                               278                                                                               35.027                                                                             18.619                                                                             10.558                                                                             1.00                                                                              26.28                                        ATOM  1731                                                                              CA  LEU                                                                               278                                                                               35.135                                                                             18.639                                                                             9.100                                                                              1.00                                                                              23.05                                        ATOM  1732                                                                              CB  LEU                                                                               278                                                                               33.947                                                                             19.402                                                                             8.480                                                                              1.00                                                                              19.55                                        ATOM  1733                                                                              CG  LEU                                                                               278                                                                               32.553                                                                             18.888                                                                             8.879                                                                              1.00                                                                              22.14                                        ATOM  1734                                                                              CD1 LEU                                                                               278                                                                               31.469                                                                             19.721                                                                             8.211                                                                              1.00                                                                              21.08                                        ATOM  1735                                                                              CD2 LEU                                                                               278                                                                               32.375                                                                             17.427                                                                             8.536                                                                              1.00                                                                              13.56                                        ATOM  1736                                                                              C   LEU                                                                               278                                                                               36.473                                                                             19.220                                                                             8.641                                                                              1.00                                                                              20.62                                        ATOM  1737                                                                              O   LEU                                                                               278                                                                               37.100                                                                             18.691                                                                             7.731                                                                              1.00                                                                              21.36                                        ATOM  1738                                                                              N   ASP                                                                               279                                                                               36.932                                                                             20.269                                                                             9.312                                                                              1.00                                                                              19.88                                        ATOM  1739                                                                              CA  ASP                                                                               279                                                                               38.205                                                                             20.904                                                                             8.965                                                                              1.00                                                                              22.41                                        ATOM  1740                                                                              CB  ASP                                                                               279                                                                               38.353                                                                             22.254                                                                             9.683                                                                              1.00                                                                              24.41                                        ATOM  1741                                                                              CG  ASP                                                                               279                                                                               37.817                                                                             23.425                                                                             8.871                                                                              1.00                                                                              24.32                                        ATOM  1742                                                                              OD1 ASP                                                                               279                                                                               37.241                                                                             23.210                                                                             7.777                                                                              1.00                                                                              23.54                                        ATOM  1743                                                                              OD2 ASP                                                                               279                                                                               38.015                                                                             24.575                                                                             9.323                                                                              1.00                                                                              23.55                                        ATOM  1744                                                                              C   ASP                                                                               279                                                                               39.428                                                                             20.016                                                                             9.242                                                                              1.00                                                                              23.05                                        ATOM  1745                                                                              O   ASP                                                                               279                                                                               40.492                                                                             20.198                                                                             8.657                                                                              1.00                                                                              27.31                                        ATOM  1746                                                                              N   LEU                                                                               280                                                                               39.263                                                                             19.032                                                                             10.113                                                                             1.00                                                                              23.67                                        ATOM  1747                                                                              CA  LEU                                                                               280                                                                               40.345                                                                             18.116                                                                             10.453                                                                             1.00                                                                              17.85                                        ATOM  1748                                                                              CB  LEU                                                                               280                                                                               40.188                                                                             17.700                                                                             11.908                                                                             1.00                                                                              12.01                                        ATOM  1749                                                                              CG  LEU                                                                               280                                                                               41.302                                                                             16.835                                                                             12.494                                                                             1.00                                                                              14.79                                        ATOM  1750                                                                              CD1 LEU                                                                               280                                                                               42.512                                                                             17.735                                                                             12.874                                                                             1.00                                                                              14.08                                        ATOM  1751                                                                              CD2 LEU                                                                               280                                                                               40.761                                                                             16.090                                                                             13.692                                                                             1.00                                                                              2.29                                         ATOM  1752                                                                              C   LEU                                                                               280                                                                               40.324                                                                             16.879                                                                             9.531                                                                              1.00                                                                              14.80                                        ATOM  1753                                                                              O   LEU                                                                               280                                                                               41.348                                                                             16.453                                                                             9.015                                                                              1.00                                                                              14.17                                        ATOM  1754                                                                              N   ILE                                                                               281                                                                               39.136                                                                             16.322                                                                             9.365                                                                              1.00                                                                              12.91                                        ATOM  1755                                                                              CA  ILE                                                                               281                                                                               38.832                                                                             15.173                                                                             8.533                                                                              1.00                                                                              13.11                                        ATOM  1756                                                                              CB  ILE                                                                               281                                                                               37.272                                                                             15.034                                                                             8.580                                                                              1.00                                                                              16.92                                        ATOM  1757                                                                              CG2 ILE                                                                               281                                                                               36.583                                                                             15.195                                                                             7.244                                                                              1.00                                                                              12.65                                        ATOM  1758                                                                              CG1 ILE                                                                               281                                                                               36.890                                                                             13.820                                                                             9.397                                                                              1.00                                                                              21.95                                        ATOM  1759                                                                              CD1 ILE                                                                               281                                                                               37.394                                                                             13.892                                                                             10.805                                                                             1.00                                                                              26.87                                        ATOM  1760                                                                              C   ILE                                                                               281                                                                               39.427                                                                             15.268                                                                             7.089                                                                              1.00                                                                              18.88                                        ATOM  1761                                                                              O   ILE                                                                               281                                                                               39.820                                                                             14.243                                                                             6.490                                                                              1.00                                                                              15.78                                        ATOM  1762                                                                              N   VAL                                                                               282                                                                               39.530                                                                             16.494                                                                             6.555                                                                              1.00                                                                              17.36                                        ATOM  1763                                                                              CA  VAL                                                                               282                                                                               40.089                                                                             16.771                                                                             5.209                                                                              1.00                                                                              14.13                                        ATOM  1764                                                                              CB  VAL                                                                               282                                                                               40.002                                                                             18.262                                                                             4.876                                                                              1.00                                                                              14.53                                        ATOM  1765                                                                              CG1 VAL                                                                               282                                                                               40.212                                                                             18.503                                                                             3.418                                                                              1.00                                                                              14.65                                        ATOM  1766                                                                              CG2 VAL                                                                               282                                                                               38.751                                                                             18.844                                                                             5.403                                                                              1.00                                                                              18.35                                        ATOM  1767                                                                              C   VAL                                                                               282                                                                               41.598                                                                             16.479                                                                             5.106                                                                              1.00                                                                              17.65                                        ATOM  1768                                                                              O   VAL                                                                               282                                                                               42.124                                                                             16.243                                                                             4.014                                                                              1.00                                                                              17.42                                        ATOM  1769                                                                              N   LEU                                                                               283                                                                               42.304                                                                             16.627                                                                             6.221                                                                              1.00                                                                              18.73                                        ATOM  1770                                                                              CA  LEU                                                                               283                                                                               43.745                                                                             16.415                                                                             6.261                                                                              1.00                                                                              16.39                                        ATOM  1771                                                                              CB  LEU                                                                               283                                                                               44.326                                                                             17.141                                                                             7.461                                                                              1.00                                                                              14.57                                        ATOM  1772                                                                              CG  LEU                                                                               283                                                                               44.022                                                                             18.624                                                                             7.450                                                                              1.00                                                                              13.01                                        ATOM  1773                                                                              CD1 LEU                                                                               283                                                                               44.519                                                                             19.279                                                                             8.693                                                                              1.00                                                                              12.84                                        ATOM  1774                                                                              CD2 LEU                                                                               283                                                                               44.674                                                                             19.230                                                                             6.256                                                                              1.00                                                                              16.22                                        ATOM  1775                                                                              C   LEU                                                                               283                                                                               44.170                                                                             14.953                                                                             6.301                                                                              1.00                                                                              17.30                                        ATOM  1776                                                                              O   LEU                                                                               283                                                                               45.294                                                                             14.644                                                                             5.929                                                                              1.00                                                                              22.88                                        ATOM  1777                                                                              N   PHE                                                                               284                                                                               43.277                                                                             14.053                                                                             6.709                                                                              1.00                                                                              15.61                                        ATOM  1778                                                                              CA  PHE                                                                               284                                                                               43.603                                                                             12.626                                                                             6.804                                                                              1.00                                                                              15.45                                        ATOM  1779                                                                              CB  PHE                                                                               284                                                                               42.359                                                                             11.777                                                                             7.096                                                                              1.00                                                                              14.83                                        ATOM  1780                                                                              CG  PHE                                                                               284                                                                               41.812                                                                             11.897                                                                             8.507                                                                              1.00                                                                              18.52                                        ATOM  1781                                                                              CD1 PHE                                                                               284                                                                               42.400                                                                             12.723                                                                             9.451                                                                              1.00                                                                              14.14                                        ATOM  1782                                                                              CD2 PHE                                                                               284                                                                               40.646                                                                             11.184                                                                             8.864                                                                              1.00                                                                              16.50                                        ATOM  1783                                                                              CE1 PHE                                                                               284                                                                               41.825                                                                             12.837                                                                             10.714                                                                             1.00                                                                              15.64                                        ATOM  1784                                                                              CE2 PHE                                                                               284                                                                               40.090                                                                             11.295                                                                             10.092                                                                             1.00                                                                              7.62                                         ATOM  1785                                                                              CZ  PHE                                                                               284                                                                               40.670                                                                             12.122                                                                             11.019                                                                             1.00                                                                              9.46                                         ATOM  1786                                                                              C   PHE                                                                               284                                                                               44.310                                                                             12.002                                                                             5.592                                                                              1.00                                                                              18.21                                        ATOM  1787                                                                              O   PHE                                                                               284                                                                               45.276                                                                             11.266                                                                             5.760                                                                              1.00                                                                              23.49                                        ATOM  1788                                                                              N   PRO                                                                               285                                                                               43.851                                                                             12.276                                                                             4.352                                                                              1.00                                                                              20.88                                        ATOM  1789                                                                              CD  PRO                                                                               285                                                                               42.694                                                                             13.049                                                                             3.863                                                                              1.00                                                                              15.13                                        ATOM  1790                                                                              CA  PRO                                                                               285                                                                               44.556                                                                             11.644                                                                             3.225                                                                              1.00                                                                              17.86                                        ATOM  1791                                                                              CB  PRO                                                                               285                                                                               43.763                                                                             12.122                                                                             2.008                                                                              1.00                                                                              14.52                                        ATOM  1792                                                                              CG  PRO                                                                               285                                                                               42.390                                                                             12.350                                                                             2.575                                                                              1.00                                                                              15.75                                        ATOM  1793                                                                              C   PRO                                                                               285                                                                               46.052                                                                             11.942                                                                             3.079                                                                              1.00                                                                              14.50                                        ATOM  1794                                                                              O   PRO                                                                               285                                                                               46.769                                                                             11.186                                                                             2.424                                                                              1.00                                                                              14.19                                        ATOM  1795                                                                              N   PHE                                                                               286                                                                               46.534                                                                             12.995                                                                             3.722                                                                              1.00                                                                              14.02                                        ATOM  1796                                                                              CA  PHE                                                                               286                                                                               47.937                                                                             13.353                                                                             3.602                                                                              1.00                                                                              11.79                                        ATOM  1797                                                                              CB  PHE                                                                               286                                                                               48.089                                                                             14.849                                                                             3.714                                                                              1.00                                                                              11.85                                        ATOM  1798                                                                              CG  PHE                                                                               286                                                                               47.175                                                                             15.597                                                                             2.800                                                                              1.00                                                                              13.93                                        ATOM  1799                                                                              CD1 PHE                                                                               286                                                                               47.188                                                                             15.346                                                                             1.436                                                                              1.00                                                                              14.94                                        ATOM  1800                                                                              CD2 PHE                                                                               286                                                                               46.257                                                                             16.502                                                                             3.302                                                                              1.00                                                                              11.76                                        ATOM  1801                                                                              CE1 PHE                                                                               286                                                                               46.281                                                                             15.990                                                                             0.576                                                                              1.00                                                                              14.08                                        ATOM  1802                                                                              CE2 PHE                                                                               286                                                                               45.348                                                                             17.150                                                                             2.455                                                                              1.00                                                                              14.35                                        ATOM  1803                                                                              CZ  PHE                                                                               286                                                                               45.365                                                                             16.887                                                                             1.089                                                                              1.00                                                                              13.45                                        ATOM  1804                                                                              C   PHE                                                                               286                                                                               48.849                                                                             12.631                                                                             4.571                                                                              1.00                                                                              16.19                                        ATOM  1805                                                                              O   PHE                                                                               286                                                                               50.038                                                                             12.936                                                                             4.670                                                                              1.00                                                                              21.52                                        ATOM  1806                                                                              N   TYR                                                                               287                                                                               48.291                                                                             11.685                                                                             5.315                                                                              1.00                                                                              19.21                                        ATOM  1807                                                                              CA  TYR                                                                               287                                                                               49.077                                                                             10.892                                                                             6.256                                                                              1.00                                                                              20.55                                        ATOM  1808                                                                              CB  TYR                                                                               287                                                                               48.225                                                                             10.397                                                                             7.441                                                                              1.00                                                                              19.17                                        ATOM  1809                                                                              CG  TYR                                                                               287                                                                               47.739                                                                             11.484                                                                             8.362                                                                              1.00                                                                              16.07                                        ATOM  1810                                                                              CD1 TYR                                                                               287                                                                               48.456                                                                             12.671                                                                             8.498                                                                              1.00                                                                              20.52                                        ATOM  1811                                                                              CE1 TYR                                                                               287                                                                               48.005                                                                             13.696                                                                             9.351                                                                              1.00                                                                              24.03                                        ATOM  1812                                                                              CD2 TYR                                                                               287                                                                               46.560                                                                             11.335                                                                             9.097                                                                              1.00                                                                              15.61                                        ATOM  1813                                                                              CE2 TYR                                                                               287                                                                               46.101                                                                             12.339                                                                             9.943                                                                              1.00                                                                              16.01                                        ATOM  1814                                                                              CZ  TYR                                                                               287                                                                               46.820                                                                             13.517                                                                             10.064                                                                             1.00                                                                              20.29                                        ATOM  1815                                                                              OH  TYR                                                                               287                                                                               46.359                                                                             14.558                                                                             10.833                                                                             1.00                                                                              21.44                                        ATOM  1816                                                                              C   TYR                                                                               287                                                                               49.579                                                                             9.699                                                                              5.457                                                                              1.00                                                                              21.38                                        ATOM  1817                                                                              O   TYR                                                                               287                                                                               50.471                                                                             8.979                                                                              5.898                                                                              1.00                                                                              23.27                                        ATOM  1818                                                                              N   ASP                                                                               288                                                                               48.971                                                                             9.469                                                                              4.298                                                                              1.00                                                                              17.30                                        ATOM  1819                                                                              CA  ASP                                                                               288                                                                               49.378                                                                             8.368                                                                              3.430                                                                              1.00                                                                              17.56                                        ATOM  1820                                                                              CB  ASP                                                                               288                                                                               48.270                                                                             8.102                                                                              2.397                                                                              1.00                                                                              17.03                                        ATOM  1821                                                                              CG  ASP                                                                               288                                                                               48.601                                                                             6.972                                                                              1.427                                                                              1.00                                                                              19.23                                        ATOM  1822                                                                              OD1 ASP                                                                               288                                                                               47.665                                                                             6.510                                                                              0.764                                                                              1.00                                                                              16.04                                        ATOM  1823                                                                              OD2 ASP                                                                               288                                                                               49.766                                                                             6.541                                                                              1.309                                                                              1.00                                                                              19.93                                        ATOM  1824                                                                              C   ASP                                                                               288                                                                               50.666                                                                             8.884                                                                              2.774                                                                              1.00                                                                              17.17                                        ATOM  1825                                                                              O   ASP                                                                               288                                                                               50.652                                                                             9.342                                                                              1.634                                                                              1.00                                                                              15.73                                        ATOM  1826                                                                              N   ILE                                                                               289                                                                               51.788                                                                             8.743                                                                              3.479                                                                              1.00                                                                              18.54                                        ATOM  1827                                                                              CA  ILE                                                                               289                                                                               53.066                                                                             9.246                                                                              3.001                                                                              1.00                                                                              18.37                                        ATOM  1828                                                                              CB  ILE                                                                               289                                                                               54.042                                                                             9.459                                                                              4.194                                                                              1.00                                                                              19.04                                        ATOM  1829                                                                              CG2 ILE                                                                               289                                                                               53.428                                                                             10.472                                                                             5.175                                                                              1.00                                                                              19.10                                        ATOM  1830                                                                              CG1 ILE                                                                               289                                                                               54.324                                                                             8.143                                                                              4.926                                                                              1.00                                                                              12.09                                        ATOM  1831                                                                              CD1 ILE                                                                               289                                                                               55.331                                                                             7.259                                                                              4.239                                                                              1.00                                                                              11.61                                        ATOM  1832                                                                              C   ILE                                                                               289                                                                               53.721                                                                             8.564                                                                              1.782                                                                              1.00                                                                              21.85                                        ATOM  1833                                                                              O   ILE                                                                               289                                                                               54.834                                                                             8.930                                                                              1.363                                                                              1.00                                                                              23.95                                        ATOM  1834                                                                              N   ARG                                                                               290                                                                               53.037                                                                             7.567                                                                              1.224                                                                              1.00                                                                              y9.57                                        ATOM  1835                                                                              CA  ARG                                                                               290                                                                               53.514                                                                             6.884                                                                              0.029                                                                              1.00                                                                              18.74                                        ATOM  1836                                                                              CB  ARG                                                                               290                                                                               53.182                                                                             5.394                                                                              0.051                                                                              1.00                                                                              17.14                                        ATOM  1837                                                                              CG  ARG                                                                               290                                                                               54.014                                                                             4.639                                                                              1.056                                                                              1.00                                                                              23.48                                        ATOM  1838                                                                              CD  ARG                                                                               290                                                                               53.876                                                                             3.149                                                                              0.876                                                                              1.00                                                                              34.60                                        ATOM  1839                                                                              NE  ARG                                                                               290                                                                               54.451                                                                             2.353                                                                              1.973                                                                              1.00                                                                              46.59                                        ATOM  1840                                                                              CZ  ARG                                                                               290                                                                               55.735                                                                             2.347                                                                              2.346                                                                              1.00                                                                              47.76                                        ATOM  1841                                                                              NH1 ARG                                                                               290                                                                               56.626                                                                             3.117                                                                              1.725                                                                              1.00                                                                              51.55                                        ATOM  1842                                                                              NH2 ARG                                                                               290                                                                               56.149                                                                             1.501                                                                              3.292                                                                              1.00                                                                              45.76                                        ATOM  1843                                                                              C   ARG                                                                               290                                                                               52.847                                                                             7.567                                                                              -1.151                                                                             1.00                                                                              16.63                                        ATOM  1844                                                                              O   ARG                                                                               290                                                                               53.488                                                                             7.832                                                                              -2.144                                                                             1.00                                                                              19.86                                        ATOM  1845                                                                              N   LEU                                                                               291                                                                               51.578                                                                             7.914                                                                              -1.011                                                                             1.00                                                                              13.74                                        ATOM  1846                                                                              CA  LEU                                                                               291                                                                               50.849                                                                             8.592                                                                              -2.084                                                                             1.00                                                                              15.52                                        ATOM  1847                                                                              CB  LEU                                                                               291                                                                               49.355                                                                             8.420                                                                              -1.874                                                                             1.00                                                                              13.32                                        ATOM  1848                                                                              CG  LEU                                                                               291                                                                               48.362                                                                             8.707                                                                              -2.984                                                                             1.00                                                                              16.72                                        ATOM  1849                                                                              CD1 LEU                                                                               291                                                                               48.440                                                                             7.651                                                                              -4.049                                                                             1.00                                                                              17.92                                        ATOM  1850                                                                              CD2 LEU                                                                               291                                                                               47.010                                                                             8.654                                                                              -2.355                                                                             1.00                                                                              17.47                                        ATOM  1851                                                                              C   LEU                                                                               291                                                                               51.231                                                                             10.077                                                                             -2.104                                                                             1.00                                                                              18.05                                        ATOM  1852                                                                              O   LEU                                                                               291                                                                               51.168                                                                             10.722                                                                             -3.145                                                                             1.00                                                                              20.46                                        ATOM  1853                                                                              N   TYR                                                                               292                                                                               51.564                                                                             10.638                                                                             -0.941                                                                             1.00                                                                              16.65                                        ATOM  1854                                                                              CA  TYR                                                                               292                                                                               51.995                                                                             12.028                                                                             -0.857                                                                             1.00                                                                              15.57                                        ATOM  1855                                                                              CB  TYR                                                                               292                                                                               50.999                                                                             12.900                                                                             -0.118                                                                             1.00                                                                              13.30                                        ATOM  1856                                                                              CG  TYR                                                                               292                                                                               49.652                                                                             13.041                                                                             -0.770                                                                             1.00                                                                              17.69                                        ATOM  1857                                                                              CD1 TYR                                                                               292                                                                               48.642                                                                             12.118                                                                             -0.519                                                                             1.00                                                                              14.60                                        ATOM  1858                                                                              CE1 TYR                                                                               292                                                                               47.386                                                                             12.269                                                                             -1.084                                                                             1.00                                                                              11.38                                        ATOM  1859                                                                              CD2 TYR                                                                               292                                                                               49.372                                                                             14.125                                                                             -1.614                                                                             1.00                                                                              14.26                                        ATOM  1860                                                                              CE2 TYR                                                                               292                                                                               48.125                                                                             14.279                                                                             -2.186                                                                             1.00                                                                              9.45                                         ATOM  1861                                                                              CZ  TYR                                                                               292                                                                               47.136                                                                             13.349                                                                             -1.913                                                                             1.00                                                                              13.74                                        ATOM  1862                                                                              OH  TYR                                                                               292                                                                               45.880                                                                             13.498                                                                             -2.464                                                                             1.00                                                                              19.44                                        ATOM  1863                                                                              C   TYR                                                                               292                                                                               53.248                                                                             12.005                                                                             -0.040                                                                             1.00                                                                              17.77                                        ATOM  1864                                                                              O   TYR                                                                               292                                                                               53.188                                                                             12.265                                                                             1.140                                                                              1.00                                                                              21.18                                        ATOM  1865                                                                              N   SER                                                                               293                                                                               54.388                                                                             11.715                                                                             -0.652                                                                             1.00                                                                              17.12                                        ATOM  1866                                                                              CA  SER                                                                               293                                                                               55.630                                                                             11.650                                                                             0.098                                                                              1.00                                                                              18.41                                        ATOM  1867                                                                              CB  SER                                                                               293                                                                               56.527                                                                             10.586                                                                             -0.502                                                                             1.00                                                                              22.40                                        ATOM  1868                                                                              OG  SER                                                                               293                                                                               57.151                                                                             11.100                                                                             -1.661                                                                             1.00                                                                              17.65                                        ATOM  1869                                                                              C   SER                                                                               293                                                                               56.437                                                                             12.927                                                                             0.177                                                                              1.00                                                                              20.90                                        ATOM  1870                                                                              O   SER                                                                               293                                                                               57.334                                                                             13.013                                                                             1.008                                                                              1.00                                                                              27.08                                        ATOM  1871                                                                              N   LYS                                                                               294                                                                               56.134                                                                             13.911                                                                             -0.672                                                                             1.00                                                                              21.04                                        ATOM  1872                                                                              CA  LYS                                                                               294                                                                               56.899                                                                             15.174                                                                             -0.741                                                                             1.00                                                                              21.20                                        ATOM  1873                                                                              CB  LYS                                                                               294                                                                               56.888                                                                             15.687                                                                             -2.188                                                                             1.00                                                                              24.69                                        ATOM  1874                                                                              CG  LYS                                                                               294                                                                               57.667                                                                             14.826                                                                             -3.155                                                                             1.00                                                                              30.89                                        ATOM  1875                                                                              CD  LYS                                                                               294                                                                               57.400                                                                             15.182                                                                             -4.601                                                                             1.00                                                                              36.85                                        ATOM  1876                                                                              CE  LYS                                                                               294                                                                               58.381                                                                             14.457                                                                             -5.546                                                                             1.00                                                                              40.74                                        ATOM  1877                                                                              NZ  LYS                                                                               294                                                                               58.259                                                                             12.949                                                                             -5.574                                                                             1.00                                                                              49.08                                        ATOM  1878                                                                              C   LYS                                                                               294                                                                               56.464                                                                             16.329                                                                             0.148                                                                              1.00                                                                              21.21                                        ATOM  1879                                                                              O   LYS                                                                               294                                                                               57.117                                                                             17.375                                                                             0.194                                                                              1.00                                                                              24.04                                        ATOM  1880                                                                              N   GLY                                                                               295                                                                               55.374                                                                             16.150                                                                             0.863                                                                              1.00                                                                              19.05                                        ATOM  1881                                                                              CA  GLY                                                                               295                                                                               54.852                                                                             17.243                                                                             1.660                                                                              1.00                                                                              23.45                                        ATOM  1882                                                                              C   GLY                                                                               295                                                                               53.652                                                                             17.716                                                                             0.870                                                                              1.00                                                                              19.08                                        ATOM  1883                                                                              O   GLY                                                                               295                                                                               53.586                                                                             17.408                                                                             -0.305                                                                             1.00                                                                              25.31                                        ATOM  1884                                                                              N   VAL                                                                               296                                                                               52 691                                                                             18.410                                                                             1.466                                                                              1.00                                                                              16.95                                        ATOM  1885                                                                              CA  VAL                                                                               296                                                                               51.539                                                                             18.844                                                                             0.690                                                                              1.00                                                                              17.59                                        ATOM  1886                                                                              CB  VAL                                                                               296                                                                               50.299                                                                             17.958                                                                             0.980                                                                              1.00                                                                              15.37                                        ATOM  1887                                                                              CG1 VAL                                                                               296                                                                               49.139                                                                             18.372                                                                             0.110                                                                              1.00                                                                              11.50                                        ATOM  1888                                                                              CG2 VAL                                                                               296                                                                               50.612                                                                             16.502                                                                             0.708                                                                              1.00                                                                              18.57                                        ATOM  1889                                                                              C   VAL                                                                               296                                                                               51.182                                                                             20.302                                                                             0.956                                                                              1.00                                                                              20.48                                        ATOM  1890                                                                              O   VAL                                                                               296                                                                               51.102                                                                             20.722                                                                             2.108                                                                              1.00                                                                              27.73                                        ATOM  1891                                                                              N   LYS                                                                               297                                                                               50.985                                                                             21.077                                                                             -0.106                                                                             1.00                                                                              19.95                                        ATOM  1892                                                                              CA  LYS                                                                               297                                                                               50.604                                                                             22.472                                                                             0.027                                                                              1.00                                                                              19.51                                        ATOM  1893                                                                              CB  LYS                                                                               297                                                                               51.444                                                                             23.358                                                                             -0.888                                                                             1.00                                                                              21.95                                        ATOM  1894                                                                              CG  LYS                                                                               297                                                                               51.011                                                                             24.799                                                                             -0.891                                                                             1.00                                                                              23.34                                        ATOM  1895                                                                              CD  LYS                                                                               297                                                                               51.814                                                                             25.617                                                                             -1.892                                                                             1.00                                                                              24.37                                        ATOM  1896                                                                              CE  LYS                                                                               297                                                                               51.247                                                                             27.021                                                                             -2.068                                                                             1.00                                                                              24.23                                        ATOM  1897                                                                              NZ  LYS                                                                               297                                                                               49.881                                                                             27.038                                                                             -2.664                                                                             1.00                                                                              23.46                                        ATOM  1898                                                                              C   LYS                                                                               297                                                                               49.143                                                                             22.532                                                                             -0.371                                                                             1.00                                                                              20.96                                        ATOM  1899                                                                              O   LYS                                                                               297                                                                               48.816                                                                             22.330                                                                             -1.533                                                                             1.00                                                                              21.98                                        ATOM  1900                                                                              N   THR                                                                               298                                                                               48.268                                                                             22.633                                                                             0.626                                                                              1.00                                                                              21.00                                        ATOM  1901                                                                              CA  THR                                                                               298                                                                               46.839                                                                             22.728                                                                             0.400                                                                              1.00                                                                              22.17                                        ATOM  1902                                                                              CB  THR                                                                               298                                                                               46.094                                                                             21.394                                                                             0.679                                                                              1.00                                                                              24.36                                        ATOM  1903                                                                              OG1 THR                                                                               298                                                                               44.705                                                                             21.551                                                                             0.328                                                                              1.00                                                                              21.16                                        ATOM  1904                                                                              CG2 THR                                                                               298                                                                               46.242                                                                             20.949                                                                             2.132                                                                              1.00                                                                              13.02                                        ATOM  1905                                                                              C   THR                                                                               298                                                                               46.203                                                                             23.850                                                                             1.210                                                                              1.00                                                                              21.58                                        ATOM  1906                                                                              O   THR                                                                               298                                                                               46.881                                                                             24.562                                                                             1.936                                                                              1.00                                                                              22.42                                        ATOM  1907                                                                              N   GLU                                                                               299                                                                               44.897                                                                             24.020                                                                             1.069                                                                              1.00                                                                              20.01                                        ATOM  1908                                                                              CA  GLU                                                                               299                                                                               44.202                                                                             25.069                                                                             1.790                                                                              1.00                                                                              23.19                                        ATOM  1909                                                                              CB  GLU                                                                               299                                                                               44.394                                                                             26.388                                                                             1.028                                                                              1.00                                                                              21.52                                        ATOM  1910                                                                              CG  GLU                                                                               299                                                                               44.111                                                                             26.241                                                                             -0.457                                                                             1.00                                                                              24.08                                        ATOM  1911                                                                              CD  GLU                                                                               299                                                                               44.281                                                                             27.511                                                                             -1.246                                                                             1.00                                                                              21.25                                        ATOM  1912                                                                              OE1 GLU                                                                               299                                                                               43.347                                                                             27.904                                                                             -1.952                                                                             1.00                                                                              23.36                                        ATOM  1913                                                                              OE2 GLU                                                                               299                                                                               45.363                                                                             28.099                                                                             -1.199                                                                             1.00                                                                              25.32                                        ATOM  1914                                                                              C   GLU                                                                               299                                                                               42.709                                                                             24.689                                                                             1.942                                                                              1.00                                                                              22.52                                        ATOM  1915                                                                              O   GLU                                                                               299                                                                               42.226                                                                             23.799                                                                             1.218                                                                              1.00                                                                              21.89                                        ATOM  1916                                                                              N   LEU                                                                               300                                                                               42.031                                                                             25.288                                                                             2.935                                                                              1.00                                                                              18.80                                        ATOM  1917                                                                              CA  LEU                                                                               300                                                                               40.599                                                                             25.057                                                                             3.208                                                                              1.00                                                                              17.80                                        ATOM  1918                                                                              CB  LEU                                                                               300                                                                               40.346                                                                             24.957                                                                             4.716                                                                              1.00                                                                              18.20                                        ATOM  1919                                                                              CG  LEU                                                                               300                                                                               41.052                                                                             23.781                                                                             5.409                                                                              1.00                                                                              18.16                                        ATOM  1920                                                                              CD1 LEU                                                                               300                                                                               41.281                                                                             24.050                                                                             6.878                                                                              1.00                                                                              22.65                                        ATOM  1921                                                                              CD2 LEU                                                                               300                                                                               40.232                                                                             22.548                                                                             5.238                                                                              1.00                                                                              21.52                                        ATOM  1922                                                                              C   LEU                                                                               300                                                                               39.835                                                                             26.246                                                                             2.626                                                                              1.00                                                                              15.99                                        ATOM  1923                                                                              O   LEU                                                                               300                                                                               40.070                                                                             27.384                                                                             3.019                                                                              1.00                                                                              15.87                                        ATOM  1924                                                                              N   THR                                                                               301                                                                               38.920                                                                             25.988                                                                             1.697                                                                              1.00                                                                              16.43                                        ATOM  1925                                                                              CA  THR                                                                               301                                                                               38.198                                                                             27.078                                                                             1.039                                                                              1.00                                                                              16.67                                        ATOM  1926                                                                              CB  THR                                                                               301                                                                               38.204                                                                             26.860                                                                             -0.486                                                                             1.00                                                                              15.99                                        ATOM  1927                                                                              OG1 THR                                                                               301                                                                               37.397                                                                             25.725                                                                             -0.795                                                                             1.00                                                                              17.35                                        ATOM  1928                                                                              CG2 THR                                                                               301                                                                               39.629                                                                             26.604                                                                             -1.001                                                                             1.00                                                                              12.86                                        ATOM  1929                                                                              C   THR                                                                               301                                                                               36.750                                                                             27.381                                                                             1.451                                                                              1.00                                                                              16.97                                        ATOM  1930                                                                              O   THR                                                                               301                                                                               36.115                                                                             28.216                                                                             0.849                                                                              1.00                                                                              20.08                                        ATOM  1931                                                                              N   ARG                                                                               302                                                                               36.239                                                                             26.775                                                                             2.509                                                                              1.00                                                                              20.61                                        ATOM  1932                                                                              CA  ARG                                                                               302                                                                               34.849                                                                             27.007                                                                             2.891                                                                              1.00                                                                              21.32                                        ATOM  1933                                                                              CB  ARG                                                                               302                                                                               34.287                                                                             25.864                                                                             3.750                                                                              1.00                                                                              18.48                                        ATOM  1934                                                                              CG  ARG                                                                               302                                                                               34.722                                                                             25.893                                                                             5.198                                                                              1.00                                                                              14.88                                        ATOM  1935                                                                              CD  ARG                                                                               302                                                                               36.172                                                                             25.671                                                                             5.287                                                                              1.00                                                                              9.35                                         ATOM  1936                                                                              NE  ARG                                                                               302                                                                               36.696                                                                             25.844                                                                             6.621                                                                              1.00                                                                              20.42                                        ATOM  1937                                                                              CZ  ARG                                                                               302                                                                               37.108                                                                             27.008                                                                             7.107                                                                              1.00                                                                              22.97                                        ATOM  1938                                                                              NH1 ARG                                                                               302                                                                               37.594                                                                             27.070                                                                             8.346                                                                              1.00                                                                              22.13                                        ATOM  1939                                                                              NH2 ARG                                                                               302                                                                               36.999                                                                             28.107                                                                             6.368                                                                              1.00                                                                              17.69                                        ATOM  1940                                                                              C   ARG                                                                               302                                                                               34.591                                                                             28.299                                                                             3.621                                                                              1.00                                                                              20.20                                        ATOM  1941                                                                              O   ARG                                                                               302                                                                               35.471                                                                             28.855                                                                             4.271                                                                              1.00                                                                              17.57                                        ATOM  1942                                                                              N   ASP                                                                               303                                                                               33.346                                                                             28.737                                                                             3.495                                                                              1.00                                                                              25.15                                        ATOM  1943                                                                              CA  ASP                                                                               303                                                                               32.809                                                                             29.930                                                                             4.140                                                                              1.00                                                                              26.98                                        ATOM  1944                                                                              CB  ASP                                                                               303                                                                               31.470                                                                             30.313                                                                             3.515                                                                              1.00                                                                              26.18                                        ATOM  1945                                                                              CG  ASP                                                                               303                                                                               31.601                                                                             30.933                                                                             2.177                                                                              1.00                                                                              29.18                                        ATOM  1946                                                                              OD1 ASP                                                                               303                                                                               32.703                                                                             31.375                                                                             1.800                                                                              1.00                                                                              37.69                                        ATOM  1947                                                                              OD2 ASP                                                                               303                                                                               30.568                                                                             31.017                                                                             1.497                                                                              1.00                                                                              35.54                                        ATOM  1948                                                                              C   ASP                                                                               303                                                                               32.469                                                                             29.534                                                                             5.571                                                                              1.00                                                                              28.25                                        ATOM  1949                                                                              O   ASP                                                                               303                                                                               31.989                                                                             28.421                                                                             5.828                                                                              1.00                                                                              31.50                                        ATOM  1950                                                                              N   ILE                                                                               304                                                                               32.606                                                                             30.486                                                                             6.475                                                                              1.00                                                                              26.71                                        ATOM  1951                                                                              CA  ILE                                                                               304                                                                               32.283                                                                             30.267                                                                             7.862                                                                              1.00                                                                              25.31                                        ATOM  1952                                                                              CB  ILE                                                                               304                                                                               33.569                                                                             30.156                                                                             8.723                                                                              1.00                                                                              22.72                                        ATOM  1953                                                                              CG2 ILE                                                                               304                                                                               33.322                                                                             30.558                                                                             10.144                                                                             1.00                                                                              20.05                                        ATOM  1954                                                                              CG1 ILE                                                                               304                                                                               34.034                                                                             28.714                                                                             8.723                                                                              1.00                                                                              19.75                                        ATOM  1955                                                                              CD1 ILE                                                                               304                                                                               32.954                                                                             27.806                                                                             9.196                                                                              1.00                                                                              14.92                                        ATOM  1956                                                                              C   ILE                                                                               304                                                                               31.423                                                                             31.448                                                                             8.250                                                                              1.00                                                                              26.33                                        ATOM  1957                                                                              O   ILE                                                                               304                                                                               31.748                                                                             32.595                                                                             7.922                                                                              1.00                                                                              25.80                                        ATOM  1958                                                                              N   PHE                                                                               305                                                                               30.268                                                                             31.152                                                                             8.835                                                                              1.00                                                                              28.50                                        ATOM  1959                                                                              CA  PHE                                                                               305                                                                               29.344                                                                             32.188                                                                             9.293                                                                              1.00                                                                              31.16                                        ATOM  1960                                                                              CB  PHE                                                                               305                                                                               27.912                                                                             31.852                                                                             8.877                                                                              1.00                                                                              36.40                                        ATOM  1961                                                                              CG  PHE                                                                               305                                                                               27.662                                                                             32.026                                                                             7.432                                                                              1.00                                                                              42.07                                        ATOM  1962                                                                              CD1 PHE                                                                               305                                                                               27.899                                                                             30.985                                                                             6.549                                                                              1.00                                                                              46.03                                        ATOM  1963                                                                              CD2 PHE                                                                               305                                                                               27.261                                                                             33.254                                                                             6.938                                                                              1.00                                                                              49.89                                        ATOM  1964                                                                              CE1 PHE                                                                               305                                                                               27.752                                                                             31.156                                                                             5.185                                                                              1.00                                                                              49.49                                        ATOM  1965                                                                              CE2 PHE                                                                               305                                                                               27.106                                                                             33.446                                                                             5.571                                                                              1.00                                                                              54.89                                        ATOM  1966                                                                              CZ  PHE                                                                               305                                                                               27.357                                                                             32.389                                                                             4.689                                                                              1.00                                                                              54.32                                        ATOM  1967                                                                              C   PHE                                                                               305                                                                               29.375                                                                             32.382                                                                             10.814                                                                             1.00                                                                              29.64                                        ATOM  1968                                                                              O   PHE                                                                               305                                                                               28.992                                                                             31.475                                                                             11.567                                                                             1.00                                                                              25.99                                        ATOM  1969                                                                              N   THR                                                                               306                                                                               29.882                                                                             33.533                                                                             11.261                                                                             1.00                                                                              28.12                                        ATOM  1970                                                                              CA  THR                                                                               306                                                                               29.873                                                                             33.837                                                                             12.679                                                                             1.00                                                                              28.81                                        ATOM  1971                                                                              CB  THR                                                                               306                                                                               30.779                                                                             35.048                                                                             13.049                                                                             1.00                                                                              26.16                                        ATOM  1972                                                                              OG1 THR                                                                               306                                                                               30.624                                                                             36.078                                                                             12.082                                                                             1.00                                                                              27.19                                        ATOM  1973                                                                              CG2 THR                                                                               306                                                                               32.246                                                                             34.647                                                                             13.127                                                                             1.00                                                                              20.81                                        ATOM  1974                                                                              C   THR                                                                               306                                                                               28.387                                                                             34.136                                                                             12.965                                                                             1.00                                                                              30.50                                        ATOM  1975                                                                              O   THR                                                                               306                                                                               27.599                                                                             34.289                                                                             12.034                                                                             1.00                                                                              32.53                                        ATOM  1976                                                                              N   ASP                                                                               307                                                                               27.981                                                                             34.164                                                                             14.229                                                                             1.00                                                                              30.85                                        ATOM  1977                                                                              CA  ASP                                                                               307                                                                               26.582                                                                             34.411                                                                             14.551                                                                             1.00                                                                              28.56                                        ATOM  1978                                                                              CB  ASP                                                                               307                                                                               26.331                                                                             34.154                                                                             16.028                                                                             1.00                                                                              27.80                                        ATOM  1979                                                                              CG  ASP                                                                               307                                                                               26.639                                                                             32.741                                                                             16.427                                                                             1.00                                                                              25.34                                        ATOM  1980                                                                              OD1 ASP                                                                               307                                                                               26.394                                                                             31.814                                                                             15.621                                                                             1.00                                                                              27.45                                        ATOM  1981                                                                              OD2 ASP                                                                               307                                                                               27.126                                                                             32.565                                                                             17.556                                                                             1.00                                                                              26.95                                        ATOM  1982                                                                              C   ASP                                                                               307                                                                               26.203                                                                             35.830                                                                             14.234                                                                             1.00                                                                              29.47                                        ATOM  1983                                                                              O   ASP                                                                               307                                                                               27.060                                                                             36.690                                                                             14.098                                                                             1.00                                                                              32.38                                        ATOM  1984                                                                              N   PRO                                                                               308                                                                               24.905                                                                             36.104                                                                             14.119                                                                             1.00                                                                              32.45                                        ATOM  1985                                                                              CD  PRO                                                                               308                                                                               23.768                                                                             35.163                                                                             14.163                                                                             1.00                                                                              31.35                                        ATOM  1986                                                                              CA  PRO                                                                               308                                                                               24.467                                                                             37.472                                                                             13.815                                                                             1.00                                                                              34.04                                        ATOM  1987                                                                              CB  PRO                                                                               308                                                                               22.958                                                                             37.360                                                                             13.956                                                                             1.00                                                                              34.15                                        ATOM  1988                                                                              CG  PRO                                                                               308                                                                               22.694                                                                             35.936                                                                             13.472                                                                             1.00                                                                              32.85                                        ATOM  1989                                                                              C   PRO                                                                               308                                                                               25.098                                                                             38.483                                                                             14.800                                                                             1.00                                                                              37.93                                        ATOM  1990                                                                              O   PRO                                                                               308                                                                               25.202                                                                             38.187                                                                             15.998                                                                             1.00                                                                              37.44                                        ATOM  1991                                                                              N   ILE                                                                               309                                                                               25.503                                                                             39.659                                                                             14.296                                                                             1.00                                                                              40.34                                        ATOM  1992                                                                              CA  ILE                                                                               309                                                                               26.182                                                                             40.696                                                                             15.097                                                                             1.00                                                                              43.93                                        ATOM  1993                                                                              CB  ILE                                                                               309                                                                               26.369                                                                             42.034                                                                             14.319                                                                             1.00                                                                              48.28                                        ATOM  1994                                                                              CG2 ILE                                                                               309                                                                               26.862                                                                             43.148                                                                             15.252                                                                             1.00                                                                              51.65                                        ATOM  1995                                                                              CG1 ILE                                                                               309                                                                               27.437                                                                             41.892                                                                             13.240                                                                             1.00                                                                              49.09                                        ATOM  1996                                                                              CD1 ILE                                                                               309                                                                               27.842                                                                             43.242                                                                             12.649                                                                             1.00                                                                              46.27                                        ATOM  1997                                                                              C   ILE                                                                               309                                                                               25.651                                                                             40.995                                                                             16.506                                                                             1.00                                                                              44.62                                        ATOM  1998                                                                              O   ILE                                                                               309                                                                               26.432                                                                             41.296                                                                             17.431                                                                             1.00                                                                              41.13                                        ATOM  1999                                                                              N   PHE                                                                               310                                                                               24.341                                                                             41.003                                                                             16.675                                                                             1.00                                                                              42.38                                        ATOM  2000                                                                              CA  PHE                                                                               310                                                                               23.843                                                                             41.236                                                                             18.003                                                                             1.00                                                                              41.16                                        ATOM  2001                                                                              CB  PHE                                                                               310                                                                               23.491                                                                             42.705                                                                             18.235                                                                             1.00                                                                              44.88                                        ATOM  2002                                                                              CG  PHE                                                                               310                                                                               22.411                                                                             43.235                                                                             17.351                                                                             1.00                                                                              44.58                                        ATOM  2003                                                                              CD1 PHE                                                                               310                                                                               21.077                                                                             43.166                                                                             17.747                                                                             1.00                                                                              44.20                                        ATOM  2004                                                                              CD2 PHE                                                                               310                                                                               22.724                                                                             43.860                                                                             16.159                                                                             1.00                                                                              38.66                                        ATOM  2005                                                                              CE1 PHE                                                                               310                                                                               20.076                                                                             43.717                                                                             16.967                                                                             1.00                                                                              42.71                                        ATOM  2006                                                                              CE2 PHE                                                                               310                                                                               21.735                                                                             44.406                                                                             15.386                                                                             1.00                                                                              41.33                                        ATOM  2007                                                                              CZ  PHE                                                                               310                                                                               20.404                                                                             44.337                                                                             15.789                                                                             1.00                                                                              42.16                                        ATOM  2008                                                                              C   PHE                                                                               310                                                                               22.717                                                                             40.301                                                                             18.347                                                                             1.00                                                                              44.75                                        ATOM  2009                                                                              O   PHE                                                                               310                                                                               21.985                                                                             39.837                                                                             17.482                                                                             1.00                                                                              43.78                                        ATOM  2010                                                                              N   SER                                                                               311                                                                               22.633                                                                             39.981                                                                             19.627                                                                             1.00                                                                              51.28                                        ATOM  2011                                                                              CA  SER                                                                               311                                                                               21.629                                                                             39.064                                                                             20.151                                                                             1.00                                                                              56.76                                        ATOM  2012                                                                              CB  SER                                                                               311                                                                               22.166                                                                             38.462                                                                             21.440                                                                             1.00                                                                              58.74                                        ATOM  2013                                                                              OG  SER                                                                               311                                                                               23.083                                                                             39.374                                                                             22.031                                                                             1.00                                                                              61.15                                        ATOM  2014                                                                              C   SER                                                                               311                                                                               20.271                                                                             39.696                                                                             20.410                                                                             1.00                                                                              57.21                                        ATOM  2015                                                                              O   SER                                                                               311                                                                               20.125                                                                             40.505                                                                             21.328                                                                             1.00                                                                              59.60                                        ATOM  2016                                                                              N   LEU                                                                               312                                                                               19.275                                                                             39.303                                                                             19.625                                                                             1.00                                                                              57.51                                        ATOM  2017                                                                              CA  LEU                                                                               312                                                                               17.921                                                                             39.828                                                                             19.779                                                                             1.00                                                                              58.49                                        ATOM  2018                                                                              CB  LEU                                                                               312                                                                               17.065                                                                             39.425                                                                             18.573                                                                             1.00                                                                              53.40                                        ATOM  2019                                                                              CG  LEU                                                                               312                                                                               17.575                                                                             39.521                                                                             17.136                                                                             1.00                                                                              49.68                                        ATOM  2020                                                                              CD1 LEU                                                                               312                                                                               16.401                                                                             39.249                                                                             16.208                                                                             1.00                                                                              45.27                                        ATOM  2021                                                                              CD2 LEU                                                                               312                                                                               18.174                                                                             40.885                                                                             16.843                                                                             1.00                                                                              49.90                                        ATOM  2022                                                                              C   LEU                                                                               312                                                                               17.316                                                                             39.231                                                                             21.057                                                                             1.00                                                                              60.36                                        ATOM  2023                                                                              O   LEU                                                                               312                                                                               16.569                                                                             38.269                                                                             21.001                                                                             1.00                                                                              64.66                                        ATOM  2024                                                                              N   ASN                                                                               313                                                                               17.651                                                                             39.786                                                                             22.210                                                                             1.00                                                                              60.93                                        ATOM  2025                                                                              CA  ASN                                                                               313                                                                               17.137                                                                             39.258                                                                             23.471                                                                             1.00                                                                              63.91                                        ATOM  2026                                                                              CB  ASN                                                                               313                                                                               17.737                                                                             40.037                                                                             24.667                                                                             1.00                                                                              71.17                                        ATOM  2027                                                                              CG  ASN                                                                               313                                                                               17.813                                                                             41.566                                                                             24.434                                                                             1.00                                                                              75.38                                        ATOM  2028                                                                              OD1 ASN                                                                               313                                                                               16.997                                                                             42.160                                                                             23.718                                                                             1.00                                                                              78.86                                        ATOM  2029                                                                              ND2 ASN                                                                               313                                                                               18.789                                                                             42.199                                                                             25.067                                                                             1.00                                                                              76.26                                        ATOM  2030                                                                              C   ASN                                                                               313                                                                               15.601                                                                             39.188                                                                             23.555                                                                             1.00                                                                              62.62                                        ATOM  2031                                                                              O   ASN                                                                               313                                                                               14.989                                                                             38.133                                                                             23.364                                                                             1.00                                                                              59.81                                        ATOM  2032                                                                              N   THR                                                                               314                                                                               14.990                                                                             40.330                                                                             23.839                                                                             1.00                                                                              61.63                                        ATOM  2033                                                                              CA  THR                                                                               314                                                                               13.549                                                                             40.458                                                                             23.948                                                                             1.00                                                                              57.86                                        ATOM  2034                                                                              CB  THR                                                                               314                                                                               13.217                                                                             41.790                                                                             24.674                                                                             1.00                                                                              58.51                                        ATOM  2035                                                                              OG1 THR                                                                               314                                                                               13.881                                                                             41.819                                                                             25.946                                                                             1.00                                                                              58.32                                        ATOM  2036                                                                              CG2 THR                                                                               314                                                                               11.724                                                                             41.947                                                                             24.888                                                                             1.00                                                                              59.87                                        ATOM  2037                                                                              C   THR                                                                               314                                                                               12.970                                                                             40.457                                                                             22.523                                                                             1.00                                                                              55.92                                        ATOM  2038                                                                              O   THR                                                                               314                                                                               11.767                                                                             40.260                                                                             22.327                                                                             1.00                                                                              55.62                                        ATOM  2039                                                                              N   LEU                                                                               315                                                                               13.856                                                                             40.624                                                                             21.537                                                                             1.00                                                                              52.11                                        ATOM  2040                                                                              CA  LEU                                                                               315                                                                               13.486                                                                             40.683                                                                             20.122                                                                             1.00                                                                              49.01                                        ATOM  2041                                                                              CB  LEU                                                                               315                                                                               14.320                                                                             41.757                                                                             19.404                                                                             1.00                                                                              50.14                                        ATOM  2042                                                                              CG  LEU                                                                               315                                                                               14.328                                                                             43.217                                                                             19.874                                                                             1.00                                                                              50.23                                        ATOM  2043                                                                              CD1 LEU                                                                               315                                                                               14.815                                                                             44.078                                                                             18.718                                                                             1.00                                                                              51.73                                        ATOM  2044                                                                              CD2 LEU                                                                               315                                                                               12.933                                                                             43.680                                                                             20.328                                                                             1.00                                                                              47.63                                        ATOM  2045                                                                              C   LEU                                                                               315                                                                               13.621                                                                             39.375                                                                             19.347                                                                             1.00                                                                              47.16                                        ATOM  2046                                                                              O   LEU                                                                               315                                                                               13.292                                                                             39.312                                                                             18.157                                                                             1.00                                                                              43.27                                        ATOM  2047                                                                              N   GLN                                                                               316                                                                               14.097                                                                             38.340                                                                             20.023                                                                             1.00                                                                              47.36                                        ATOM  2048                                                                              CA  GLN                                                                               316                                                                               14.311                                                                             37.036                                                                             19.414                                                                             1.00                                                                              48.53                                        ATOM  2049                                                                              CB  GLN                                                                               316                                                                               14.411                                                                             35.977                                                                             20.510                                                                             1.00                                                                              51.64                                        ATOM  2050                                                                              CG  GLN                                                                               316                                                                               15.051                                                                             34.673                                                                             20.073                                                                             1.00                                                                              57.31                                        ATOM  2051                                                                              CD  GLN                                                                               316                                                                               16.565                                                                             34.769                                                                             19.894                                                                             1.00                                                                              60.35                                        ATOM  2052                                                                              OE1 GLN                                                                               316                                                                               17.108                                                                             35.810                                                                             19.506                                                                             1.00                                                                              60.96                                        ATOM  2053                                                                              NE2 GLN                                                                               316                                                                               17.254                                                                             33.665                                                                             20.169                                                                             1.00                                                                              63.62                                        ATOM  2054                                                                              C   GLN                                                                               316                                                                               13.200                                                                             36.663                                                                             18.451                                                                             1.00                                                                              49.57                                        ATOM  2055                                                                              O   GLN                                                                               316                                                                               13.454                                                                             36.241                                                                             17.320                                                                             1.00                                                                              50.18                                        ATOM  2056                                                                              N   GLU                                                                               317                                                                               11.968                                                                             36.870                                                                             18.901                                                                             1.00                                                                              48.85                                        ATOM  2057                                                                              CA  GLU                                                                               317                                                                               10.775                                                                             36.544                                                                             18.126                                                                             1.00                                                                              52.71                                        ATOM  2058                                                                              CB  GLU                                                                               317                                                                               9.501                                                                              36.796                                                                             18.953                                                                             1.00                                                                              60.20                                        ATOM  2059                                                                              CG  GLU                                                                               317                                                                               9.493                                                                              36.204                                                                             20.377                                                                             1.00                                                                              70.71                                        ATOM  2060                                                                              CD  GLU                                                                               317                                                                               9.881                                                                              37.227                                                                             21.456                                                                             1.00                                                                              76.72                                        ATOM  2061                                                                              OE1 GLU                                                                               317                                                                               9.273                                                                              38.333                                                                             21.480                                                                             1.00                                                                              77.12                                        ATOM  2062                                                                              OE2 GLU                                                                               317                                                                               10.787                                                                             36.920                                                                             22.274                                                                             1.00                                                                              77.99                                        ATOM  2063                                                                              C   GLU                                                                               317                                                                               10.657                                                                             37.293                                                                             16.799                                                                             1.00                                                                              48.71                                        ATOM  2064                                                                              O   GLU                                                                               317                                                                               10.071                                                                             36.780                                                                             15.844                                                                             1.00                                                                              48.70                                        ATOM  2065                                                                              N   TYR                                                                               318                                                                               11.214                                                                             38.494                                                                             16.739                                                                             1.00                                                                              43.49                                        ATOM  2066                                                                              CA  TYR                                                                               318                                                                               11.129                                                                             39.300                                                                             15.538                                                                             1.00                                                                              39.92                                        ATOM  2067                                                                              CB  TYR                                                                               318                                                                               10.999                                                                             40.761                                                                             15.918                                                                             1.00                                                                              42.45                                        ATOM  2068                                                                              CG  TYR                                                                               318                                                                               9.803                                                                              40.971                                                                             16.782                                                                             1.00                                                                              42.68                                        ATOM  2069                                                                              CD1 TYR                                                                               318                                                                               9.946                                                                              41.197                                                                             18.144                                                                             1.00                                                                              40.60                                        ATOM  2070                                                                              CE1 TYR                                                                               318                                                                               8.849                                                                              41.304                                                                             18.969                                                                             1.00                                                                              40.01                                        ATOM  2071                                                                              CD2 TYR                                                                               318                                                                               8.526                                                                              40.860                                                                             16.260                                                                             1.00                                                                              38.85                                        ATOM  2072                                                                              CE2 TYR                                                                               318                                                                               7.424                                                                              40.969                                                                             17.078                                                                             1.00                                                                              40.89                                        ATOM  2073                                                                              CZ  TYR                                                                               318                                                                               7.593                                                                              41.189                                                                             18.437                                                                             1.00                                                                              39.14                                        ATOM  2074                                                                              OH  TYR                                                                               318                                                                               6.503                                                                              41.297                                                                             19.273                                                                             1.00                                                                              45.54                                        ATOM  2075                                                                              C   TYR                                                                               318                                                                               12.233                                                                             39.130                                                                             14.522                                                                             1.00                                                                              37.64                                        ATOM  2076                                                                              O   TYR                                                                               318                                                                               12.303                                                                             39.886                                                                             13.561                                                                             1.00                                                                              38.76                                        ATOM  2077                                                                              N   GLY                                                                               319                                                                               13.093                                                                             38.141                                                                             14.703                                                                             1.00                                                                              35.33                                        ATOM  2078                                                                              CA  GLY                                                                               319                                                                               14.154                                                                             37.962                                                                             13.733                                                                             1.00                                                                              31.25                                        ATOM  2079                                                                              C   GLY                                                                               319                                                                               13.662                                                                             37.273                                                                             12.476                                                                             1.00                                                                              30.50                                        ATOM  2080                                                                              O   GLY                                                                               319                                                                               12.575                                                                             36.689                                                                             12.500                                                                             1.00                                                                              32.90                                        ATOM  2081                                                                              N   PRO                                                                               320                                                                               14.385                                                                             37.395                                                                             11.344                                                                             1.00                                                                              26.91                                        ATOM  2082                                                                              CD  PRO                                                                               320                                                                               15.499                                                                             38.333                                                                             11.174                                                                             1.00                                                                              23.64                                        ATOM  2083                                                                              CA  PRO                                                                               320                                                                               14.061                                                                             36.776                                                                             10.053                                                                             1.00                                                                              29.07                                        ATOM  2084                                                                              CB  PRO                                                                               320                                                                               15.295                                                                             37.106                                                                             9.210                                                                              1.00                                                                              29.08                                        ATOM  2085                                                                              CG  PRO                                                                               320                                                                               16.336                                                                             37.590                                                                             10.207                                                                             1.00                                                                              28.14                                        ATOM  2086                                                                              C   PRO                                                                               320                                                                               13.880                                                                             35.251                                                                             10.152                                                                             1.00                                                                              30.61                                        ATOM  2087                                                                              O   PRO                                                                               320                                                                               14.650                                                                             34.591                                                                             10.831                                                                             1.00                                                                              32.60                                        ATOM  2088                                                                              N   THR                                                                               321                                                                               12.899                                                                             34.685                                                                             9.451                                                                              1.00                                                                              32.83                                        ATOM  2089                                                                              CA  THR                                                                               321                                                                               12.676                                                                             33.245                                                                             9.523                                                                              1.00                                                                              36.83                                        ATOM  2090                                                                              CB  THR                                                                               321                                                                               11.362                                                                             32.782                                                                             8.776                                                                              1.00                                                                              41.13                                        ATOM  2091                                                                              OG1 THR                                                                               321                                                                               11.482                                                                             32.904                                                                             7.346                                                                              1.00                                                                              35.95                                        ATOM  2092                                                                              CG2 THR                                                                               321                                                                               10.177                                                                             33.597                                                                             9.267                                                                              1.00                                                                              40.68                                        ATOM  2093                                                                              C   THR                                                                               321                                                                               13.871                                                                             32.438                                                                             9.041                                                                              1.00                                                                              37.20                                        ATOM  2094                                                                              O   THR                                                                               321                                                                               14.789                                                                             32.985                                                                             8.429                                                                              1.00                                                                              41.10                                        ATOM  2095                                                                              N   PHE                                                                               322                                                                               13.873                                                                             31.149                                                                             9.369                                                                              1.00                                                                              38.20                                        ATOM  2096                                                                              CA  PHE                                                                               322                                                                               14.941                                                                             30.216                                                                             8.993                                                                              1.00                                                                              36.64                                        ATOM  2097                                                                              CB  PHE                                                                               322                                                                               14.548                                                                             28.794                                                                             9.455                                                                              1.00                                                                              35.09                                        ATOM  2098                                                                              CG  PHE                                                                               322                                                                               15.669                                                                             27.776                                                                             9.400                                                                              1.00                                                                              37.60                                        ATOM  2099                                                                              CD1 PHE                                                                               322                                                                               16.356                                                                             27.416                                                                             10.554                                                                             1.00                                                                              36.41                                        ATOM  2101                                                                              CE1 PHE                                                                               322                                                                               17.359                                                                             26.466                                                                             10.505                                                                             1.00                                                                              32.41                                        ATOM  2102                                                                              CE2 PHE                                                                               322                                                                               17.012                                                                             26.216                                                                             8.159                                                                              1.00                                                                              25.56                                        ATOM  2103                                                                              CZ  PHE                                                                               322                                                                               17.682                                                                             25.872                                                                             9.307                                                                              1.00                                                                              28.83                                        ATOM  2104                                                                              C   PHE                                                                               322                                                                               15.139                                                                             30.260                                                                             7.470                                                                              1.00                                                                              34.25                                        ATOM  2105                                                                              O   PHE                                                                               322                                                                               16.191                                                                             30.671                                                                             6.987                                                                              1.00                                                                              26.49                                        ATOM  2106                                                                              N   LEU                                                                               323                                                                               14.081                                                                             29.907                                                                             6.739                                                                              1.00                                                                              36.36                                        ATOM  2107                                                                              CA  LEU                                                                               323                                                                               14.078                                                                             29.876                                                                             5.281                                                                              1.00                                                                              39.50                                        ATOM  2108                                                                              CB  LEU                                                                               323                                                                               12.713                                                                             29.427                                                                             4.739                                                                              1.00                                                                              46.13                                        ATOM  2109                                                                              CG  LEU                                                                               323                                                                               12.323                                                                             27.951                                                                             4.927                                                                              1.00                                                                              50.61                                        ATOM  2110                                                                              CD1 LEU                                                                               323                                                                               10.873                                                                             27.714                                                                             4.506                                                                              1.00                                                                              52.63                                        ATOM  2111                                                                              CD2 LEU                                                                               323                                                                               13.267                                                                             27.041                                                                             4.131                                                                              1.00                                                                              52.44                                        ATOM  2112                                                                              C   LEU                                                                               323                                                                               14.486                                                                             31.183                                                                             4.627                                                                              1.00                                                                              41.16                                        ATOM  2113                                                                              O   LEU                                                                               323                                                                               15.230                                                                             31.174                                                                             3.651                                                                              1.00                                                                              45.33                                        ATOM  2114                                                                              N   SER                                                                               324                                                                               14.006                                                                             32.310                                                                             5.132                                                                              1.00                                                                              40.97                                        ATOM  2115                                                                              CA  SER                                                                               324                                                                               14.400                                                                             33.583                                                                             4.545                                                                              1.00                                                                              43.00                                        ATOM  2116                                                                              CB  SER                                                                               324                                                                               13.565                                                                             34.730                                                                             5.111                                                                              1.00                                                                              47.79                                        ATOM  2117                                                                              OG  SER                                                                               324                                                                               13.504                                                                             34.673                                                                             6.527                                                                              1.00                                                                              60.21                                        ATOM  2118                                                                              C   SER                                                                               324                                                                               15.892                                                                             33.840                                                                             4.774                                                                              1.00                                                                              40.32                                        ATOM  2119                                                                              O   SER                                                                               324                                                                               16.524                                                                             34.581                                                                             4.031                                                                              1.00                                                                              40.93                                        ATOM  2120                                                                              N   ILE                                                                               325                                                                               16.457                                                                             33.237                                                                             5.808                                                                              1.00                                                                              38.03                                        ATOM  2121                                                                              CA  ILE                                                                               325                                                                               17.863                                                                             33.420                                                                             6.060                                                                              1.00                                                                              35.42                                        ATOM  2122                                                                              CB  ILE                                                                               325                                                                               18.206                                                                             33.218                                                                             7.502                                                                              1.00                                                                              32.99                                        ATOM  2123                                                                              CG2 ILE                                                                               325                                                                               19.698                                                                             33.445                                                                             7.696                                                                              1.00                                                                              32.52                                        ATOM  2124                                                                              CG1 ILE                                                                               325                                                                               17.402                                                                             34.213                                                                             8.338                                                                              1.00                                                                              29.14                                        ATOM  2125                                                                              CD1 ILE                                                                               325                                                                               17.483                                                                             33.959                                                                             9.785                                                                              1.00                                                                              28.48                                        ATOM  2126                                                                              C   ILE                                                                               325                                                                               18.647                                                                             32.464                                                                             5.204                                                                              1.00                                                                              36.75                                        ATOM  2127                                                                              O   ILE                                                                               325                                                                               19.540                                                                             32.893                                                                             4.493                                                                              1.00                                                                              35.77                                        ATOM  2128                                                                              N   GLU                                                                               326                                                                               18.280                                                                             31.181                                                                             5.228                                                                              1.00                                                                              41.70                                        ATOM  2129                                                                              CA  GLU                                                                               326                                                                               18.958                                                                             30.159                                                                             4.420                                                                              1.00                                                                              45.37                                        ATOM  2130                                                                              CB  GLU                                                                               326                                                                               18.567                                                                             28.733                                                                             4.849                                                                              1.00                                                                              44.39                                        ATOM  2131                                                                              CG  GLU                                                                               326                                                                               19.363                                                                             28.140                                                                             6.032                                                                              1.00                                                                              46.63                                        ATOM  2132                                                                              CD  GLU                                                                               326                                                                               20.865                                                                             27.938                                                                             5.771                                                                              1.00                                                                              48.09                                        ATOM  2133                                                                              OE1 GLU                                                                               326                                                                               21.672                                                                             28.753                                                                             6.258                                                                              1.00                                                                              47.88                                        ATOM  2134                                                                              OE2 GLU                                                                               326                                                                               21.253                                                                             26.941                                                                             5.126                                                                              1.00                                                                              50.34                                        ATOM  2135                                                                              C   GLU                                                                               326                                                                               18.733                                                                             30.312                                                                             2.908                                                                              1.00                                                                              47.91                                        ATOM  2136                                                                              O   GLU                                                                               326                                                                               19.515                                                                             29.795                                                                             2.113                                                                              1.00                                                                              52.83                                        ATOM  2137                                                                              N   ASN                                                                               327                                                                               17.667                                                                             30.992                                                                             2.503                                                                              1.00                                                                              49.53                                        ATOM  2138                                                                              CA  ASN                                                                               327                                                                               17.392                                                                             31.186                                                                             1.077                                                                              1.00                                                                              50.26                                        ATOM  2139                                                                              CB  ASN                                                                               327                                                                               15.883                                                                             31.067                                                                             0.785                                                                              1.00                                                                              57.24                                        ATOM  2140                                                                              CG  ASN                                                                               327                                                                               15.348                                                                             29.639                                                                             0.923                                                                              1.00                                                                              63.35                                        ATOM  2141                                                                              OD1 ASN                                                                               327                                                                               14.362                                                                             29.271                                                                             0.272                                                                              1.00                                                                              65.72                                        ATOM  2142                                                                              ND2 ASN                                                                               327                                                                               15.973                                                                             28.838                                                                             1.787                                                                              1.00                                                                              66.61                                        ATOM  2143                                                                              C   ASN                                                                               327                                                                               17.885                                                                             32.557                                                                             0.602                                                                              1.00                                                                              49.12                                        ATOM  2144                                                                              O   ASN                                                                               327                                                                               17.732                                                                             32.910                                                                             -0.566                                                                             1.00                                                                              48.41                                        ATOM  2145                                                                              N   SER                                                                               328                                                                               18.460                                                                             33.336                                                                             1.513                                                                              1.00                                                                              48.24                                        ATOM  2146                                                                              CA  SER                                                                               328                                                                               18.940                                                                             34.666                                                                             1.177                                                                              1.00                                                                              44.37                                        ATOM  2147                                                                              CB  SER                                                                               328                                                                               18.354                                                                             35.682                                                                             2.141                                                                              1.00                                                                              43.90                                        ATOM  2148                                                                              OG  SER                                                                               328                                                                               18.337                                                                             36.973                                                                             1.573                                                                              1.00                                                                              53.23                                        ATOM  2149                                                                              C   SER                                                                               328                                                                               20.448                                                                             34.713                                                                             1.234                                                                              1.00                                                                              42.82                                        ATOM  2150                                                                              O   SER                                                                               328                                                                               21.068                                                                             35.599                                                                             0.662                                                                              1.00                                                                              44.52                                        ATOM  2151                                                                              N   ILE                                                                               329                                                                               21.043                                                                             33.789                                                                             1.973                                                                              1.00                                                                              41.88                                        ATOM  2152                                                                              CA  ILE                                                                               329                                                                               22.489                                                                             33.739                                                                             2.053                                                                              1.00                                                                              43.60                                        ATOM  2153                                                                              CB  ILE                                                                               329                                                                               23.002                                                                             32.593                                                                             2.976                                                                              1.00                                                                              47.00                                        ATOM  2154                                                                              CG2 ILE                                                                               329                                                                               24.519                                                                             32.637                                                                             3.053                                                                              1.00                                                                              51.01                                        ATOM  2155                                                                              CG1 ILE                                                                               329                                                                               22.439                                                                             32.700                                                                             4.395                                                                              1.00                                                                              45.80                                        ATOM  2156                                                                              CD1 ILE                                                                               329                                                                               23.249                                                                             33.560                                                                             5.348                                                                              1.00                                                                              51.95                                        ATOM  2157                                                                              C   ILE                                                                               329                                                                               22.993                                                                             33.464                                                                             0.632                                                                              1.00                                                                              44.62                                        ATOM  2158                                                                              O   ILE                                                                               329                                                                               22.281                                                                             32.911                                                                             -0.215                                                                             1.00                                                                              42.08                                        ATOM  2159                                                                              N   ARG                                                                               330                                                                               24.244                                                                             33.838                                                                             0.409                                                                              1.00                                                                              47.30                                        ATOM  2160                                                                              CA  ARG                                                                               330                                                                               24.963                                                                             33.693                                                                             -0.851                                                                             1.00                                                                              46.81                                        ATOM  2161                                                                              CB  ARG                                                                               330                                                                               26.279                                                                             34.416                                                                             -0.638                                                                             1.00                                                                              45.98                                        ATOM  2162                                                                              CG  ARG                                                                               330                                                                               27.046                                                                             34.848                                                                             -1.827                                                                             1.00                                                                              44.32                                        ATOM  2163                                                                              CD  ARG                                                                               330                                                                               28.355                                                                             35.373                                                                             -1.277                                                                             1.00                                                                              42.48                                        ATOM  2164                                                                              NE  ARG                                                                               330                                                                               29.270                                                                             35.765                                                                             -2.322                                                                             1.00                                                                              38.20                                        ATOM  2165                                                                              CZ  ARG                                                                               330                                                                               30.584                                                                             35.790                                                                             -2.188                                                                             1.00                                                                              34.54                                        ATOM  2166                                                                              NH1 ARG                                                                               330                                                                               31.303                                                                             36.170                                                                             -3.213                                                                             1.00                                                                              39.28                                        ATOM  2167                                                                              NH2 ARG                                                                               330                                                                               31.172                                                                             35.436                                                                             -1.056                                                                             1.00                                                                              32.79                                        ATOM  2168                                                                              C   ARG                                                                               330                                                                               25.214                                                                             32.203                                                                             -1.154                                                                             1.00                                                                              47.48                                        ATOM  2169                                                                              O   ARG                                                                               330                                                                               25.815                                                                             31.492                                                                             -0.345                                                                             1.00                                                                              49.75                                        ATOM  2170                                                                              N   LYS                                                                               331                                                                               24.788                                                                             31.735                                                                             -2.323                                                                             1.00                                                                              44.85                                        ATOM  2171                                                                              CA  LYS                                                                               331                                                                               24.965                                                                             30.321                                                                             -2.677                                                                             1.00                                                                              45.45                                        ATOM  2172                                                                              CB  LYS                                                                               331                                                                               23.947                                                                             29.905                                                                             -3.755                                                                             1.00                                                                              47.94                                        ATOM  2173                                                                              CG  LYS                                                                               331                                                                               23.989                                                                             30.723                                                                             -5.023                                                                             1.00                                                                              58.90                                        ATOM  2174                                                                              CD  LYS                                                                               331                                                                               22.834                                                                             30.357                                                                             -5.938                                                                             1.00                                                                              66.64                                        ATOM  2175                                                                              CE  LYS                                                                               331                                                                               22.853                                                                             31.194                                                                             -7.215                                                                             1.00                                                                              71.89                                        ATOM  2176                                                                              NZ  LYS                                                                               331                                                                               21.564                                                                             31.088                                                                             -7.969                                                                             1.00                                                                              75.69                                        ATOM  2177                                                                              C   LYS                                                                               331                                                                               26.413                                                                             29.994                                                                             -3.086                                                                             1.00                                                                              39.16                                        ATOM  2178                                                                              O   LYS                                                                               331                                                                               27.229                                                                             30.912                                                                             -3.208                                                                             1.00                                                                              35.42                                        ATOM  2179                                                                              N   PRO                                                                               332                                                                               26.759                                                                             28.687                                                                             -3.243                                                                             1.00                                                                              36.88                                        ATOM  2180                                                                              CD  PRO                                                                               332                                                                               25.907                                                                             27.510                                                                             -2.988                                                                             1.00                                                                              34.11                                        ATOM  2181                                                                              CA  PRO                                                                               332                                                                               28.113                                                                             28.249                                                                             -3.627                                                                             1.00                                                                              35.07                                        ATOM  2182                                                                              CB  PRO                                                                               332                                                                               27.952                                                                             26.732                                                                             -3.834                                                                             1.00                                                                              31.43                                        ATOM  2183                                                                              CG  PRO                                                                               332                                                                               26.465                                                                             26.521                                                                             -3.945                                                                             1.00                                                                              34.71                                        ATOM  2184                                                                              C   PRO                                                                               332                                                                               28.695                                                                             28.993                                                                             -4.837                                                                             1.00                                                                              33.27                                        ATOM  2185                                                                              O   PRO                                                                               332                                                                               28.069                                                                             29.092                                                                             -5.891                                                                             1.00                                                                              32.47                                        ATOM  2186                                                                              N   HIS                                                                               333                                                                               29.927                                                                             29.464                                                                             -4.675                                                                             1.00                                                                              31.69                                        ATOM  2187                                                                              CA  HIS                                                                               333                                                                               30.592                                                                             30.283                                                                             -5.677                                                                             1.00                                                                              29.36                                        ATOM  2188                                                                              CB  HIS                                                                               333                                                                               30.345                                                                             31.755                                                                             -5.284                                                                             1.00                                                                              29.61                                        ATOM  2189                                                                              CG  HIS                                                                               333                                                                               30.759                                                                             32.078                                                                             -3.874                                                                             1.00                                                                              31.85                                        ATOM  2190                                                                              CD2 HIS                                                                               333                                                                               31.978                                                                             32.349                                                                             -3.343                                                                             1.00                                                                              30.11                                        ATOM  2191                                                                              ND1 HIS                                                                               333                                                                               29.879                                                                             32.052                                                                             -2.811                                                                             1.00                                                                              32.89                                        ATOM  2192                                                                              CE1 HIS                                                                               333                                                                               30.540                                                                             32.282                                                                             -1.688                                                                             1.00                                                                              33.67                                        ATOM  2193                                                                              NE2 HIS                                                                               333                                                                               31.815                                                                             32.467                                                                             -1.984                                                                             1.00                                                                              27.12                                        ATOM  2194                                                                              C   HIS                                                                               333                                                                               32.106                                                                             30.062                                                                             -5.781                                                                             1.00                                                                              25.03                                        ATOM  2195                                                                              O   HIS                                                                               333                                                                               32.719                                                                             29.414                                                                             -4.936                                                                             1.00                                                                              25.48                                        ATOM  2196                                                                              N   LEU                                                                               334                                                                               32.706                                                                             30.630                                                                             -6.817                                                                             1.00                                                                              23.62                                        ATOM  2197                                                                              CA  LEU                                                                               334                                                                               34.156                                                                             30.561                                                                             -6.982                                                                             1.00                                                                              25.27                                        ATOM  2198                                                                              CB  LEU                                                                               334                                                                               34.615                                                                             31.210                                                                             -8.298                                                                             1.00                                                                              20.89                                        ATOM  2199                                                                              CG  LEU                                                                               334                                                                               34.198                                                                             30.552                                                                             -9.612                                                                             1.00                                                                              21.30                                        ATOM  2200                                                                              CD1 LEU                                                                               334                                                                               34.810                                                                             31.273                                                                             -10.809                                                                            1.00                                                                              16.30                                        ATOM  2201                                                                              CD2 LEU                                                                               334                                                                               34.625                                                                             29.094                                                                             -9.573                                                                             1.00                                                                              19.51                                        ATOM  2202                                                                              C   LEU                                                                               334                                                                               34.668                                                                             31.415                                                                             -5.837                                                                             1.00                                                                              25.83                                        ATOM  2203                                                                              O   LEU                                                                               334                                                                               34.023                                                                             32.389                                                                             -5.461                                                                             1.00                                                                              27.82                                        ATOM  2204                                                                              N   PHE                                                                               335                                                                               35.832                                                                             31.077                                                                             -5.306                                                                             1.00                                                                              27.75                                        ATOM  2205                                                                              CA  PHE                                                                               335                                                                               36.413                                                                             31.821                                                                             -4.195                                                                             1.00                                                                              24.44                                        ATOM  2206                                                                              CB  PHE                                                                               335                                                                               37.718                                                                             31.140                                                                             -3.764                                                                             1.00                                                                              25.26                                        ATOM  2207                                                                              CG  PHE                                                                               335                                                                               38.196                                                                             31.546                                                                             -2.403                                                                             1.00                                                                              27.14                                        ATOM  2208                                                                              CD1 PHE                                                                               335                                                                               37.761                                                                             30.866                                                                             -1.269                                                                             1.00                                                                              27.42                                        ATOM  2209                                                                              CD2 PHE                                                                               335                                                                               39.077                                                                             32.609                                                                             -2.249                                                                             1.00                                                                              29.95                                        ATOM  2210                                                                              CE1 PHE                                                                               335                                                                               38.191                                                                             31.246                                                                             -0.002                                                                             1.00                                                                              31.73                                        ATOM  2211                                                                              CE2 PHE                                                                               335                                                                               39.514                                                                             32.997                                                                             -0.983                                                                             1.00                                                                              31.29                                        ATOM  2212                                                                              CZ  PHE                                                                               335                                                                               39.073                                                                             32.318                                                                             0.141                                                                              1.00                                                                              29.70                                        ATOM  2213                                                                              C   PHE                                                                               335                                                                               36.719                                                                             33.250                                                                             -4.601                                                                             1.00                                                                              21.92                                        ATOM  2214                                                                              O   PHE                                                                               335                                                                               37.287                                                                             33.463                                                                             -5.653                                                                             1.00                                                                              23.54                                        ATOM  2215                                                                              N   ASP                                                                               336                                                                               36.340                                                                             34.217                                                                             -3.772                                                                             1.00                                                                              21.21                                        ATOM  2216                                                                              CA  ASP                                                                               336                                                                               36.652                                                                             35.623                                                                             -4.018                                                                             1.00                                                                              21.48                                        ATOM  2217                                                                              CB  ASP                                                                               336                                                                               35.525                                                                             36.386                                                                             -4.718                                                                             1.00                                                                              23.79                                        ATOM  2218                                                                              CG  ASP                                                                               336                                                                               34.172                                                                             36.174                                                                             -4.083                                                                             1.00                                                                              23.35                                        ATOM  2219                                                                              OD1 ASP                                                                               336                                                                               34.038                                                                             36.239                                                                             -2.844                                                                             1.00                                                                              22.38                                        ATOM  2220                                                                              OD2 ASP                                                                               336                                                                               33.228                                                                             35.955                                                                             -4.868                                                                             1.00                                                                              31.58                                        ATOM  2221                                                                              C   ASP                                                                               336                                                                               37.061                                                                             36.300                                                                             -2.715                                                                             1.00                                                                              22.29                                        ATOM  2222                                                                              O   ASP                                                                               336                                                                               36.904                                                                             35.720                                                                             -1.661                                                                             1.00                                                                              25.71                                        ATOM  2223                                                                              N   TYR                                                                               337                                                                               37.518                                                                             37.544                                                                             -2.788                                                                             1.00                                                                              20.76                                        ATOM  2224                                                                              CA  TYR                                                                               337                                                                               38.037                                                                             38.268                                                                             -1.632                                                                             1.00                                                                              21.98                                        ATOM  2225                                                                              CB  TYR                                                                               337                                                                               39.538                                                                             38.538                                                                             -1.877                                                                             1.00                                                                              17.10                                        ATOM  2226                                                                              CG  TYR                                                                               337                                                                               40.339                                                                             37.311                                                                             -2.313                                                                             1.00                                                                              17.63                                        ATOM  2227                                                                              CD1 TYR                                                                               337                                                                               40.203                                                                             36.764                                                                             -3.590                                                                             1.00                                                                              20.68                                        ATOM  2228                                                                              CE1 TYR                                                                               337                                                                               40.875                                                                             35.572                                                                             -3.955                                                                             1.00                                                                              23.11                                        ATOM  2229                                                                              CD2 TYR                                                                               337                                                                               41.178                                                                             36.648                                                                             -1.415                                                                             1.00                                                                              23.13                                        ATOM  2230                                                                              CE2 TYR                                                                               337                                                                               41.854                                                                             35.466                                                                             -1.766                                                                             1.00                                                                              23.39                                        ATOM  2231                                                                              CZ  TYR                                                                               337                                                                               41.694                                                                             34.934                                                                             -3.030                                                                             1.00                                                                              24.50                                        ATOM  2232                                                                              OH  TYR                                                                               337                                                                               42.330                                                                             33.758                                                                             -3.332                                                                             1.00                                                                              26.47                                        ATOM  2233                                                                              C   TYR                                                                               337                                                                               37.305                                                                             39.586                                                                             -1.400                                                                             1.00                                                                              22.36                                        ATOM  2234                                                                              O   TYR                                                                               337                                                                               36.807                                                                             40.175                                                                             -2.333                                                                             1.00                                                                              24.56                                        ATOM  2235                                                                              N   LEU                                                                               338                                                                               37.283                                                                             40.079                                                                             -0.170                                                                             1.00                                                                              26.34                                        ATOM  2236                                                                              CA  LEU                                                                               338                                                                               36.590                                                                             41.342                                                                             0.121                                                                              1.00                                                                              29.06                                        ATOM  2237                                                                              CB  LEU                                                                               338                                                                               36.422                                                                             41.557                                                                             1.642                                                                              1.00                                                                              28.21                                        ATOM  2238                                                                              CG  LEU                                                                               338                                                                               35.501                                                                             42.690                                                                             2.150                                                                              1.00                                                                              25.11                                        ATOM  2239                                                                              CD1 LEU                                                                               338                                                                               34.056                                                                             42.386                                                                             1.828                                                                              1.00                                                                              24.92                                        ATOM  2240                                                                              CD2 LEU                                                                               338                                                                               35.645                                                                             42.872                                                                             3.652                                                                              1.00                                                                              24.77                                        ATOM  2241                                                                              C   LEU                                                                               338                                                                               37.318                                                                             42.542                                                                             -0.480                                                                             1.00                                                                              29.54                                        ATOM  2242                                                                              O   LEU                                                                               338                                                                               38.543                                                                             42.674                                                                             -0.332                                                                             1.00                                                                              32.83                                        ATOM  2243                                                                              N   GLN                                                                               339                                                                               36.562                                                                             43.389                                                                             -1.178                                                                             1.00                                                                              28.15                                        ATOM  2244                                                                              CA  GLN                                                                               339                                                                               37.101                                                                             44.605                                                                             -1.793                                                                             1.00                                                                              31.21                                        ATOM  2245                                                                              CB  GLN                                                                               339                                                                               36.617                                                                             44.766                                                                             -3.242                                                                             1.00                                                                              40.03                                        ATOM  2246                                                                              CG  GLN                                                                               339                                                                               37.561                                                                             44.246                                                                             -4.307                                                                             1.00                                                                              49.91                                        ATOM  2247                                                                              CD  GLN                                                                               339                                                                               38.935                                                                             44.882                                                                             -4.220                                                                             1.00                                                                              55.33                                        ATOM  2248                                                                              OE1 GLN                                                                               339                                                                               39.718                                                                             44.570                                                                             -3.316                                                                             1.00                                                                              58.04                                        ATOM  2249                                                                              NE2 GLN                                                                               339                                                                               39.235                                                                             45.786                                                                             -5.155                                                                             1.00                                                                              57.36                                        ATOM  2250                                                                              C   GLN                                                                               339                                                                               36.640                                                                             45.818                                                                             -1.007                                                                             1.00                                                                              27.69                                        ATOM  2251                                                                              O   GLN                                                                               339                                                                               37.430                                                                             46.720                                                                             -0.715                                                                             1.00                                                                              26.69                                        ATOM  2252                                                                              N   GLY                                                                               340                                                                               35.340                                                                             45.869                                                                             -0.744                                                                             1.00                                                                              21.87                                        ATOM  2253                                                                              CA  GLY                                                                               340                                                                               34.800                                                                             46.972                                                                             0.008                                                                              1.00                                                                              23.38                                        ATOM  2254                                                                              C   GLY                                                                               340                                                                               33.382                                                                             46.720                                                                             0.460                                                                              1.00                                                                              24.89                                        ATOM  2255                                                                              O   GLY                                                                               340                                                                               32.747                                                                             45.762                                                                             -0.010                                                                             1.00                                                                              19.77                                        ATOM  2256                                                                              N   ILE                                                                               341                                                                               32.918                                                                             47.555                                                                             1.400                                                                              1.00                                                                              27.43                                        ATOM  2257                                                                              CA  ILE                                                                               341                                                                               31.557                                                                             47.502                                                                             1.942                                                                              1.00                                                                              27.30                                        ATOM  2258                                                                              CB  ILE                                                                               341                                                                               31.492                                                                             47.019                                                                             3.422                                                                              1.00                                                                              27.82                                        ATOM  2259                                                                              CG2 ILE                                                                               341                                                                               30.028                                                                             46.858                                                                             3.859                                                                              1.00                                                                              26.82                                        ATOM  2260                                                                              CG1 ILE                                                                               341                                                                               32.208                                                                             45.678                                                                             3.611                                                                              1.00                                                                              28.32                                        ATOM  2261                                                                              CD1 ILE                                                                               341                                                                               32.064                                                                             45.102                                                                             5.021                                                                              1.00                                                                              20.98                                        ATOM  2262                                                                              C   ILE                                                                               341                                                                               30.975                                                                             48.918                                                                             1.915                                                                              1.00                                                                              29.75                                        ATOM  2263                                                                              O   ILE                                                                               341                                                                               31.653                                                                             49.893                                                                             2.265                                                                              1.00                                                                              30.81                                        ATOM  2264                                                                              N   GLU                                                                               342                                                                               29.727                                                                             49.011                                                                             1.471                                                                              1.00                                                                              29.58                                        ATOM  2265                                                                              CA  GLU                                                                               342                                                                               29.002                                                                             50.263                                                                             1.393                                                                              1.00                                                                              29.98                                        ATOM  2266                                                                              CB  GLU                                                                               342                                                                               28.396                                                                             50.451                                                                             0.001                                                                              1.00                                                                              33.94                                        ATOM  2267                                                                              CG  GLU                                                                               342                                                                               27.313                                                                             51.535                                                                             -0.052                                                                             1.00                                                                              44.76                                        ATOM  2268                                                                              CD  GLU                                                                               342                                                                               26.970                                                                             52.004                                                                             -1.457                                                                             1.00                                                                              47.49                                        ATOM  2269                                                                              OE1 GLU                                                                               342                                                                               27.893                                                                             52.466                                                                             -2.164                                                                             1.00                                                                              50.86                                        ATOM  2270                                                                              OE2 GLU                                                                               342                                                                               25.780                                                                             51.935                                                                             -1.841                                                                             1.00                                                                              48.19                                        ATOM  2271                                                                              C   GLU                                                                               342                                                                               27.896                                                                             50.242                                                                             2.441                                                                              1.00                                                                              30.01                                        ATOM  2272                                                                              O   GLU                                                                               342                                                                               26.846                                                                             49.619                                                                             2.267                                                                              1.00                                                                              30.06                                        ATOM  2273                                                                              N   PHE                                                                               343                                                                               28.135                                                                             50.965                                                                             3.515                                                                              1.00                                                                              29.93                                        ATOM  2274                                                                              CA  PHE                                                                               343                                                                               27.213                                                                             51.059                                                                             4.624                                                                              1.00                                                                              29.27                                        ATOM  2275                                                                              CB  PHE                                                                               343                                                                               27.986                                                                             51.523                                                                             5.836                                                                              1.00                                                                              29.40                                        ATOM  2276                                                                              CG  PHE                                                                               343                                                                               29.021                                                                             50.555                                                                             6.278                                                                              1.00                                                                              35.00                                        ATOM  2277                                                                              CD1 PHE                                                                               343                                                                               30.344                                                                             50.708                                                                             5.888                                                                              1.00                                                                              34.33                                        ATOM  2278                                                                              CD2 PHE                                                                               343                                                                               28.668                                                                             49.471                                                                             7.087                                                                              1.00                                                                              34.94                                        ATOM  2279                                                                              CE1 PHE                                                                               343                                                                               31.301                                                                             49.795                                                                             6.297                                                                              1.00                                                                              32.19                                        ATOM  2280                                                                              CE2 PHE                                                                               343                                                                               29.619                                                                             48.555                                                                             7.501                                                                              1.00                                                                              33.61                                        ATOM  2281                                                                              CZ  PHE                                                                               343                                                                               30.940                                                                             48.720                                                                             7.104                                                                              1.00                                                                              34.76                                        ATOM  2282                                                                              C   PHE                                                                               343                                                                               26.050                                                                             51.998                                                                             4.414                                                                              1.00                                                                              30.11                                        ATOM  2283                                                                              O   PHE                                                                               343                                                                               26.243                                                                             53.182                                                                             4.128                                                                              1.00                                                                              31.52                                        ATOM  2284                                                                              N   HIS                                                                               344                                                                               24.841                                                                             51.475                                                                             4.580                                                                              1.00                                                                              30.38                                        ATOM  2285                                                                              CA  HIS                                                                               344                                                                               23.624                                                                             52.280                                                                             4.450                                                                              1.00                                                                              32.05                                        ATOM  2286                                                                              CB  HIS                                                                               344                                                                               22.596                                                                             51.571                                                                             3.553                                                                              1.00                                                                              32.38                                        ATOM  2287                                                                              CG  HIS                                                                               344                                                                               22.806                                                                             51.818                                                                             2.083                                                                              1.00                                                                              33.83                                        ATOM  2288                                                                              CD2 HIS                                                                               344                                                                               23.922                                                                             51.755                                                                             1.317                                                                              1.00                                                                              32.02                                        ATOM  2289                                                                              ND1 HIS                                                                               344                                                                               21.788                                                                             52.209                                                                             1.238                                                                              1.00                                                                              30.81                                        ATOM  2290                                                                              CE1 HIS                                                                               344                                                                               22.265                                                                             52.376                                                                             0.020                                                                              1.00                                                                              29.92                                        ATOM  2291                                                                              NE2 HIS                                                                               344                                                                               23.558                                                                             52.106                                                                             0.040                                                                              1.00                                                                              32.00                                        ATOM  2292                                                                              C   HIS                                                                               344                                                                               23.076                                                                             52.567                                                                             5.855                                                                              1.00                                                                              30.97                                        ATOM  2293                                                                              O   HIS                                                                               344                                                                               22.927                                                                             51.648                                                                             6.648                                                                              1.00                                                                              31.67                                        ATOM  2294                                                                              N   THR                                                                               345                                                                               22.753                                                                             53.830                                                                             6.142                                                                              1.00                                                                              31.95                                        ATOM  2295                                                                              CA  THR                                                                               345                                                                               22.290                                                                             54.248                                                                             7.471                                                                              1.00                                                                              31.87                                        ATOM  2296                                                                              CB  THR                                                                               345                                                                               23.297                                                                             55.247                                                                             8.060                                                                              1.00                                                                              30.01                                        ATOM  2297                                                                              OG1 THR                                                                               345                                                                               24.621                                                                             54.713                                                                             7.937                                                                              1.00                                                                              37.38                                        ATOM  2298                                                                              CG2 THR                                                                               345                                                                               23.012                                                                             55.496                                                                             9.513                                                                              1.00                                                                              34.79                                        ATOM  2299                                                                              C   THR                                                                               345                                                                               20.900                                                                             54.861                                                                             7.656                                                                              1.00                                                                              30.45                                        ATOM  2306                                                                              O   THR                                                                               345                                                                               20.481                                                                             55.707                                                                             6.907                                                                              1.00                                                                              30.35                                        ATOM  2301                                                                              N   ARG                                                                               346                                                                               20.239                                                                             54.514                                                                             8.742                                                                              1.00                                                                              29.47                                        ATOM  2302                                                                              CA  ARG                                                                               346                                                                               18.931                                                                             55.064                                                                             9.021                                                                              1.00                                                                              33.75                                        ATOM  2303                                                                              CB  ARG                                                                               346                                                                               17.846                                                                             54.082                                                                             8.623                                                                              1.00                                                                              31.11                                        ATOM  2304                                                                              CG  ARG                                                                               346                                                                               17.570                                                                             54.113                                                                             7.156                                                                              1.00                                                                              37.30                                        ATOM  2305                                                                              CD  ARG                                                                               346                                                                               16.698                                                                             52.963                                                                             6.778                                                                              1.00                                                                              40.39                                        ATOM  2306                                                                              NE  ARG                                                                               346                                                                               15.435                                                                             53.390                                                                             6.214                                                                              1.00                                                                              45.12                                        ATOM  2307                                                                              CZ  ARG                                                                               346                                                                               14.267                                                                             53.208                                                                             6.816                                                                              1.00                                                                              53.06                                        ATOM  2308                                                                              NH1 ARG                                                                               346                                                                               13.159                                                                             53.615                                                                             6.225                                                                              1.00                                                                              59.78                                        ATOM  2309                                                                              NH2 ARG                                                                               346                                                                               14.197                                                                             52.647                                                                             8.015                                                                              1.00                                                                              55.83                                        ATOM  2310                                                                              C   ARG                                                                               346                                                                               18.791                                                                             55.423                                                                             10.490                                                                             1.00                                                                              35.43                                        ATOM  2311                                                                              O   ARG                                                                               346                                                                               19.589                                                                             54.982                                                                             11.323                                                                             1.00                                                                              36.81                                        ATOM  2312                                                                              N   LEU                                                                               347                                                                               17.823                                                                             56.288                                                                             10.788                                                                             1.00                                                                              37.54                                        ATOM  2313                                                                              CA  LEU                                                                               347                                                                               17.548                                                                             56.712                                                                             12.156                                                                             1.00                                                                              36.68                                        ATOM  2314                                                                              CB  LEU                                                                               347                                                                               17.019                                                                             58.138                                                                             12.180                                                                             1.00                                                                              38.30                                        ATOM  2315                                                                              CG  LEU                                                                               347                                                                               16.484                                                                             58.548                                                                             13.554                                                                             1.00                                                                              41.60                                        ATOM  2316                                                                              CD1 LEU                                                                               347                                                                               17.617                                                                             58.883                                                                             14.514                                                                             1.00                                                                              42.74                                        ATOM  2317                                                                              CD2 LEU                                                                               347                                                                               15.558                                                                             59.708                                                                             13.397                                                                             1.00                                                                              42.70                                        ATOM  2318                                                                              C   LEU                                                                               347                                                                               16.515                                                                             55.776                                                                             12.800                                                                             1.00                                                                              37.67                                        ATOM  2319                                                                              O   LEU                                                                               347                                                                               15.596                                                                             55.282                                                                             12.136                                                                             1.00                                                                              39.32                                        ATOM  2320                                                                              N   GLN                                                                               348                                                                               16.699                                                                             55.528                                                                             14.090                                                                             1.00                                                                              35.33                                        ATOM  2321                                                                              CA  GLN                                                                               348                                                                               15.829                                                                             54.669                                                                             14.881                                                                             1.00                                                                              32.60                                        ATOM  2322                                                                              CB  GLN                                                                               348                                                                               16.666                                                                             53.583                                                                             15.546                                                                             1.00                                                                              33.20                                        ATOM  2323                                                                              CG  GLN                                                                               348                                                                               15.908                                                                             52.659                                                                             16.428                                                                             1.00                                                                              36.04                                        ATOM  2324                                                                              CD  GLN                                                                               348                                                                               14.852                                                                             51.898                                                                             15.687                                                                             1.00                                                                              41.50                                        ATOM  2325                                                                              OE1 GLN                                                                               348                                                                               13.702                                                                             52.330                                                                             15.616                                                                             1.00                                                                              40.24                                        ATOM  2326                                                                              NE2 GLN                                                                               348                                                                               15.219                                                                             50.731                                                                             15.162                                                                             1.00                                                                              43.99                                        ATOM  2327                                                                              C   GLN                                                                               348                                                                               15.321                                                                             55.653                                                                             15.905                                                                             1.00                                                                              31.09                                        ATOM  2328                                                                              O   GLN                                                                               348                                                                               16.075                                                                             56.120                                                                             16.753                                                                             1.00                                                                              32.14                                        ATOM  2329                                                                              N   PRO                                                                               349                                                                               14.058                                                                             56.060                                                                             15.784                                                                             1.00                                                                              31.17                                        ATOM  2330                                                                              CD  PRO                                                                               349                                                                               13.063                                                                             55.775                                                                             14.740                                                                             1.00                                                                              32.17                                        ATOM  2331                                                                              CA  PRO                                                                               349                                                                               13.533                                                                             57.021                                                                             16.739                                                                             1.00                                                                              33.71                                        ATOM  2332                                                                              CB  PRO                                                                               349                                                                               12.323                                                                             57.590                                                                             15.993                                                                             1.00                                                                              33.92                                        ATOM  2333                                                                              CG  PRO                                                                               349                                                                               11.799                                                                             56.401                                                                             15.298                                                                             1.00                                                                              29.74                                        ATOM  2334                                                                              C   PRO                                                                               349                                                                               13.140                                                                             56.460                                                                             18.082                                                                             1.00                                                                              35.91                                        ATOM  2335                                                                              O   PRO                                                                               349                                                                               12.549                                                                             55.381                                                                             18.177                                                                             1.00                                                                              39.64                                        ATOM  2336                                                                              N   GLY                                                                               350                                                                               13.527                                                                             57.183                                                                             19.124                                                                             1.00                                                                              34.78                                        ATOM  2337                                                                              CA  GLY                                                                               350                                                                               13.145                                                                             56.802                                                                             20.463                                                                             1.00                                                                              29.91                                        ATOM  2338                                                                              C   GLY                                                                               350                                                                               11.810                                                                             57.502                                                                             20.645                                                                             1.00                                                                              28.68                                        ATOM  2339                                                                              O   GLY                                                                               350                                                                               11.538                                                                             58.539                                                                             20.041                                                                             1.00                                                                              28.73                                        ATOM  2340                                                                              N   TYR                                                                               351                                                                               10.968                                                                             56.949                                                                             21.492                                                                             1.00                                                                              31.04                                        ATOM  2341                                                                              CA  TYR                                                                               351                                                                               9.659                                                                              57.522                                                                             21.748                                                                             1.00                                                                              28.15                                        ATOM  2342                                                                              CB  TYR                                                                               351                                                                               8.939                                                                              56.667                                                                             22.782                                                                             1.00                                                                              25.11                                        ATOM  2343                                                                              CG  TYR                                                                               351                                                                               7.527                                                                              57.070                                                                             23.026                                                                             1.00                                                                              28.78                                        ATOM  2344                                                                              CD1 TYR                                                                               351                                                                               6.530                                                                              56.806                                                                             22.090                                                                             1.00                                                                              29.11                                        ATOM  2345                                                                              CE1 TYR                                                                               351                                                                               5.210                                                                              57.197                                                                             22.325                                                                             1.00                                                                              36.47                                        ATOM  2346                                                                              CD2 TYR                                                                               351                                                                               7.181                                                                              57.727                                                                             24.199                                                                             1.00                                                                              32.05                                        ATOM  2347                                                                              CE2 TYR                                                                               351                                                                               5.879                                                                              58.125                                                                             24.451                                                                             1.00                                                                              37.99                                        ATOM  2348                                                                              CZ  TYR                                                                               351                                                                               4.892                                                                              57.866                                                                             23.517                                                                             1.00                                                                              40.84                                        ATOM  2349                                                                              OH  TYR                                                                               351                                                                               3.609                                                                              58.316                                                                             23.786                                                                             1.00                                                                              43.75                                        ATOM  2350                                                                              C   TYR                                                                               351                                                                               9.751                                                                              58.974                                                                             22.194                                                                             1.00                                                                              26.00                                        ATOM  2351                                                                              O   TYR                                                                               351                                                                               8.934                                                                              59.786                                                                             21.809                                                                             1.00                                                                              29.53                                        ATOM  2352                                                                              N   PHE                                                                               352                                                                               10.785                                                                             59.307                                                                             22.952                                                                             1.00                                                                              28.14                                        ATOM  2353                                                                              CA  PHE                                                                               352                                                                               10.978                                                                             60.669                                                                             23.442                                                                             1.00                                                                              30.63                                        ATOM  2354                                                                              CB  PHE                                                                               352                                                                               11.465                                                                             60.650                                                                             24.891                                                                             1.00                                                                              34.55                                        ATOM  2355                                                                              CG  PHE                                                                               352                                                                               10.616                                                                             59.802                                                                             25.810                                                                             1.00                                                                              40.51                                        ATOM  2356                                                                              CD1 PHE                                                                               352                                                                               10.934                                                                             58.454                                                                             26.027                                                                             1.00                                                                              39.36                                        ATOM  2357                                                                              CD2 PHE                                                                               352                                                                               9.512                                                                              60.356                                                                             26.476                                                                             1.00                                                                              39.04                                        ATOM  2358                                                                              CE1 PHE                                                                               352                                                                               10.174                                                                             57.670                                                                             26.891                                                                             1.00                                                                              40.28                                        ATOM  2359                                                                              CE2 PHE                                                                               352                                                                               8.743                                                                              59.589                                                                             27.341                                                                             1.00                                                                              40.04                                        ATOM  2360                                                                              CZ  PHE                                                                               352                                                                               9.073                                                                              58.241                                                                             27.551                                                                             1.00                                                                              43.17                                        ATOM  2361                                                                              C   PHE                                                                               352                                                                               11.942                                                                             61.513                                                                             22.613                                                                             1.00                                                                              35.71                                        ATOM  2362                                                                              O   PHE                                                                               352                                                                               12.403                                                                             62.556                                                                             23.083                                                                             1.00                                                                              39.58                                        ATOM  2363                                                                              N   GLY                                                                               353                                                                               12.317                                                                             61.033                                                                             21.426                                                                             1.00                                                                              36.10                                        ATOM  2364                                                                              CA  GLY                                                                               353                                                                               13.201                                                                             61.791                                                                             20.549                                                                             1.00                                                                              37.76                                        ATOM  2365                                                                              C   GLY                                                                               353                                                                               14.656                                                                             62.037                                                                             20.933                                                                             1.00                                                                              40.10                                        ATOM  2366                                                                              O   GLY                                                                               353                                                                               15.544                                                                             62.011                                                                             20.072                                                                             1.00                                                                              41.93                                        ATOM  2367                                                                              N   LYS                                                                               354                                                                               14.928                                                                             62.314                                                                             22.196                                                                             1.00                                                                              37.55                                        ATOM  2368                                                                              CA  LYS                                                                               354                                                                               16.308                                                                             62.558                                                                             22.585                                                                             1.00                                                                              40.81                                        ATOM  2369                                                                              CB  LYS                                                                               354                                                                               16.381                                                                             63.243                                                                             23.966                                                                             1.00                                                                              46.62                                        ATOM  2370                                                                              CG  LYS                                                                               354                                                                               17.574                                                                             64.209                                                                             24.106                                                                             1.00                                                                              50.82                                        ATOM  2371                                                                              CD  LYS                                                                               354                                                                               17.955                                                                             64.543                                                                             25.558                                                                             1.00                                                                              55.27                                        ATOM  2372                                                                              CE  LYS                                                                               354                                                                               19.409                                                                             65.106                                                                             25.624                                                                             1.00                                                                              59.06                                        ATOM  2373                                                                              NZ  LYS                                                                               354                                                                               19.989                                                                             65.226                                                                             27.011                                                                             1.00                                                                              61.08                                        ATOM  2374                                                                              C   LYS                                                                               354                                                                               17.097                                                                             61.243                                                                             22.597                                                                             1.00                                                                              39.24                                        ATOM  2375                                                                              O   LYS                                                                               354                                                                               18.321                                                                             61.243                                                                             22.467                                                                             1.00                                                                              39.45                                        ATOM  2376                                                                              N   ASP                                                                               355                                                                               16.387                                                                             60.130                                                                             22.746                                                                             1.00                                                                              36.63                                        ATOM  2377                                                                              CA  ASP                                                                               355                                                                               17.014                                                                             58.811                                                                             22.784                                                                             1.00                                                                              36.64                                        ATOM  2378                                                                              CB  ASP                                                                               355                                                                               16.433                                                                             57.956                                                                             23.918                                                                             1.00                                                                              38.81                                        ATOM  2379                                                                              CG  ASP                                                                               355                                                                               14.899                                                                             57.893                                                                             23.905                                                                             1.00                                                                              39.86                                        ATOM  2380                                                                              OD1 ASP                                                                               355                                                                               14.329                                                                             57.075                                                                             24.666                                                                             1.00                                                                              39.20                                        ATOM  2381                                                                              OD2 ASP                                                                               355                                                                               14.258                                                                             58.674                                                                             23.174                                                                             1.00                                                                              41.91                                        ATOM  2382                                                                              C   ASP                                                                               355                                                                               16.921                                                                             58.048                                                                             21.467                                                                             1.00                                                                              36.41                                        ATOM  2383                                                                              O   ASP                                                                               355                                                                               16.687                                                                             56.839                                                                             21.459                                                                             1.00                                                                              39.46                                        ATOM  2384                                                                              N   SER                                                                               356                                                                               17.033                                                                             58.767                                                                             20.358                                                                             1.00                                                                              32.11                                        ATOM  2385                                                                              CA  SER                                                                               356                                                                               16.985                                                                             58.155                                                                             19.049                                                                             1.00                                                                              31.06                                        ATOM  2386                                                                              CB  SER                                                                               356                                                                               16.313                                                                             59.112                                                                             18.075                                                                             1.00                                                                              32.06                                        ATOM  2387                                                                              OG  SER                                                                               356                                                                               15.076                                                                             59.546                                                                             18.599                                                                             1.00                                                                              35.15                                        ATOM  2388                                                                              C   SER                                                                               356                                                                               18.426                                                                             57.884                                                                             18.613                                                                             1.00                                                                              32.46                                        ATOM  2389                                                                              O   SER                                                                               356                                                                               19.356                                                                             58.546                                                                             19.091                                                                             1.00                                                                              33.43                                        ATOM  2390                                                                              N   PHE                                                                               357                                                                               18.635                                                                             56.914                                                                             17.730                                                                             1.00                                                                              31.20                                        ATOM  2391                                                                              CA  PHE                                                                               357                                                                               19.994                                                                             56.635                                                                             17.280                                                                             1.00                                                                              30.41                                        ATOM  2392                                                                              CB  PHE                                                                               357                                                                               20.662                                                                             55.552                                                                             18.150                                                                             1.00                                                                              26.65                                        ATOM  2393                                                                              CG  PHE                                                                               357                                                                               20.023                                                                             54.184                                                                             18.032                                                                             1.00                                                                              26.35                                        ATOM  2394                                                                              CD1 PHE                                                                               357                                                                               20.538                                                                             53.228                                                                             17.146                                                                             1.00                                                                              24.89                                        ATOM  2395                                                                              CD2 PHE                                                                               357                                                                               18.915                                                                             53.852                                                                             18.797                                                                             1.00                                                                              25.64                                        ATOM  2396                                                                              CE1 PHE                                                                               357                                                                               19.963                                                                             51.973                                                                             17.024                                                                             1.00                                                                              20.16                                        ATOM  2397                                                                              CE2 PHE                                                                               357                                                                               18.323                                                                             52.588                                                                             18.685                                                                             1.00                                                                              23.45                                        ATOM  2398                                                                              CZ  PHE                                                                               357                                                                               18.851                                                                             51.649                                                                             17.794                                                                             1.00                                                                              25.99                                        ATOM  2399                                                                              C   PHE                                                                               357                                                                               20.008                                                                             56.223                                                                             15.825                                                                             1.00                                                                              30.71                                        ATOM  2400                                                                              O   PHE                                                                               357                                                                               18.985                                                                             55.809                                                                             15.275                                                                             1.00                                                                              29.78                                        ATOM  2401                                                                              N   ASN                                                                               358                                                                               21.155                                                                             56.405                                                                             15.187                                                                             1.00                                                                              32.57                                        ATOM  2402                                                                              CA  ASN                                                                               358                                                                               21.326                                                                             56.021                                                                             13.795                                                                             1.00                                                                              33.87                                        ATOM  2403                                                                              CB  ASN                                                                               358                                                                               22.252                                                                             57.010                                                                             13.070                                                                             1.00                                                                              35.37                                        ATOM  2404                                                                              CG  ASN                                                                               358                                                                               21.633                                                                             58.398                                                                             12.892                                                                             1.00                                                                              37.55                                        ATOM  2405                                                                              OD1 ASN                                                                               358                                                                               22.327                                                                             59.358                                                                             12.511                                                                             1.00                                                                              38.07                                        ATOM  2406                                                                              ND2 ASN                                                                               358                                                                               20.336                                                                             58.517                                                                             13.162                                                                             1.00                                                                              37.72                                        ATOM  2407                                                                              C   ASN                                                                               358                                                                               21.954                                                                             54.622                                                                             13.846                                                                             1.00                                                                              33.48                                        ATOM  2408                                                                              O   ASN                                                                               358                                                                               22.761                                                                             54.341                                                                             14.736                                                                             1.00                                                                              31.82                                        ATOM  2409                                                                              N   TYR                                                                               359                                                                               21.570                                                                             53.744                                                                             12.924                                                                             1.00                                                                              33.09                                        ATOM  2410                                                                              CA  TYR                                                                               359                                                                               22.093                                                                             52.381                                                                             12.901                                                                             1.00                                                                              33.75                                        ATOM  2411                                                                              CB  TYR                                                                               359                                                                               21.098                                                                             51.434                                                                             13.563                                                                             1.00                                                                              33.52                                        ATOM  2412                                                                              CG  TYR                                                                               359                                                                               19.782                                                                             51.352                                                                             12.818                                                                             1.00                                                                              34.92                                        ATOM  2413                                                                              CD1 TYR                                                                               359                                                                               19.449                                                                             50.224                                                                             12.055                                                                             1.00                                                                              33.07                                        ATOM  2414                                                                              CE1 TYR                                                                               359                                                                               18.265                                                                             50.165                                                                             11.326                                                                             1.00                                                                              29.76                                        ATOM  2415                                                                              CD2 TYR                                                                               359                                                                               18.889                                                                             52.420                                                                             12.834                                                                             1.00                                                                              37.77                                        ATOM  2416                                                                              CE2 TYR                                                                               359                                                                               17.696                                                                             52.374                                                                             12.104                                                                             1.00                                                                              38.88                                        ATOM  2417                                                                              CZ  TYR                                                                               359                                                                               17.396                                                                             51.246                                                                             11.354                                                                             1.00                                                                              36.77                                        ATOM  2418                                                                              OH  TYR                                                                               359                                                                               16.235                                                                             51.223                                                                             10.618                                                                             1.00                                                                              35.92                                        ATOM  2419                                                                              C   TYR                                                                               359                                                                               22.231                                                                             51.978                                                                             11.454                                                                             1.00                                                                              35.05                                        ATOM  2420                                                                              O   TYR                                                                               359                                                                               21.526                                                                             52.545                                                                             10.615                                                                             1.00                                                                              36.86                                        ATOM  2421                                                                              N   TRP                                                                               360                                                                               23.110                                                                             51.022                                                                             11.128                                                                             1.00                                                                              34.37                                        ATOM  2422                                                                              CA  TRP                                                                               360                                                                               23.178                                                                             50.647                                                                             9.731                                                                              1.00                                                                              32.80                                        ATOM  2423                                                                              CB  TRP                                                                               360                                                                               24.568                                                                             50.271                                                                             9.210                                                                              1.00                                                                              38.80                                        ATOM  2424                                                                              CG  TRP                                                                               360                                                                               25.172                                                                             48.996                                                                             9.571                                                                              1.00                                                                              40.63                                        ATOM  2425                                                                              CD2 TRP                                                                               360                                                                               25.669                                                                             48.006                                                                             8.655                                                                              1.00                                                                              39.06                                        ATOM  2426                                                                              CE2 TRP                                                                               360                                                                               26.392                                                                             47.049                                                                             9.423                                                                              1.00                                                                              40.29                                        ATOM  2427                                                                              CE3 TRP                                                                               360                                                                               25.591                                                                             47.840                                                                             7.275                                                                              1.00                                                                              27.60                                        ATOM  2428                                                                              CD1 TRP                                                                               360                                                                               25.564                                                                             48.606                                                                             10.808                                                                             1.00                                                                              46.32                                        ATOM  2429                                                                              NE1 TRP                                                                               360                                                                               26.307                                                                             47.437                                                                             10.732                                                                             1.00                                                                              48.10                                        ATOM  2430                                                                              CZ2 TRP                                                                               360                                                                               27.033                                                                             45.945                                                                             8.852                                                                              1.00                                                                              36.63                                        ATOM  2431                                                                              CZ3 TRP                                                                               360                                                                               26.224                                                                             46.743                                                                             6.708                                                                              1.00                                                                              33.68                                        ATOM  2432                                                                              CH2 TRP                                                                               360                                                                               26.942                                                                             45.810                                                                             7.498                                                                              1.00                                                                              36.39                                        ATOM  2433                                                                              C   TRP                                                                               360                                                                               22.091                                                                             49.678                                                                             9.390                                                                              1.00                                                                              29.48                                        ATOM  2434                                                                              O   TRP                                                                               360                                                                               21.916                                                                             48.662                                                                             10.043                                                                             1.00                                                                              28.40                                        ATOM  2435                                                                              N   SER                                                                               361                                                                               21.291                                                                             50.100                                                                             8.422                                                                              1.00                                                                              24.82                                        ATOM  2436                                                                              CA  SER                                                                               361                                                                               20.118                                                                             49.390                                                                             7.966                                                                              1.00                                                                              25.01                                        ATOM  2437                                                                              CB  SER                                                                               361                                                                               19.040                                                                             50.417                                                                             7.657                                                                              1.00                                                                              25.02                                        ATOM  2438                                                                              OG  SER                                                                               361                                                                               19.534                                                                             51.372                                                                             6.728                                                                              1.00                                                                              28.01                                        ATOM  2439                                                                              C   SER                                                                               361                                                                               20.272                                                                             48.481                                                                             6.770                                                                              1.00                                                                              25.86                                        ATOM  2440                                                                              O   SER                                                                               361                                                                               19.452                                                                             47.584                                                                             6.563                                                                              1.00                                                                              28.24                                        ATOM  2441                                                                              N   GLY                                                                               362                                                                               21.287                                                                             48.721                                                                             5.955                                                                              1.00                                                                              26.61                                        ATOM  2442                                                                              CA  GLY                                                                               362                                                                               21.470                                                                             47.893                                                                             4.775                                                                              1.00                                                                              26.68                                        ATOM  2443                                                                              C   GLY                                                                               362                                                                               22.843                                                                             48.075                                                                             4.174                                                                              1.00                                                                              24.88                                        ATOM  2444                                                                              O   GLY                                                                               362                                                                               23.624                                                                             48.876                                                                             4.681                                                                              1.00                                                                              25.16                                        ATOM  2445                                                                              N   ASN                                                                               363                                                                               23.135                                                                             47.385                                                                             3.078                                                                              1.00                                                                              24.77                                        ATOM  2446                                                                              CA  ASN                                                                               363                                                                               24.459                                                                             47.503                                                                             2.494                                                                              1.00                                                                              25.21                                        ATOM  2447                                                                              CB  ASN                                                                               363                                                                               25.510                                                                             46.904                                                                             3.453                                                                              1.00                                                                              21.78                                        ATOM  2448                                                                              CG  ASN                                                                               363                                                                               25.509                                                                             45.366                                                                             3.479                                                                              1.00                                                                              24.03                                        ATOM  2449                                                                              OD1 ASN                                                                               363                                                                               26.521                                                                             44.736                                                                             3.172                                                                              1.00                                                                              24.61                                        ATOM  2450                                                                              ND2 ASN                                                                               363                                                                               24.396                                                                             44.762                                                                             3.893                                                                              1.00                                                                              26.86                                        ATOM  2451                                                                              C   ASN                                                                               363                                                                               24.598                                                                             46.810                                                                             1.166                                                                              1.00                                                                              28.38                                        ATOM  2452                                                                              O   ASN                                                                               363                                                                               23.737                                                                             46.009                                                                             0.783                                                                              1.00                                                                              27.10                                        ATOM  2453                                                                              N   TYR                                                                               364                                                                               25.684                                                                             47.158                                                                             0.477                                                                              1.00                                                                              29.28                                        ATOM  2454                                                                              CA  TYR                                                                               364                                                                               26.101                                                                             46.545                                                                             -0.782                                                                             1.00                                                                              30.49                                        ATOM  2455                                                                              CB  TYR                                                                               364                                                                               26.241                                                                             47.570                                                                             -1.888                                                                             1.00                                                                              30.92                                        ATOM  2456                                                                              CG  TYR                                                                               364                                                                               24.976                                                                             47.958                                                                             -2.584                                                                             1.00                                                                              35.24                                        ATOM  2457                                                                              CD1 TYR                                                                               364                                                                               24.508                                                                             49.266                                                                             -2.504                                                                             1.00                                                                              37.00                                        ATOM  2458                                                                              CE1 TYR                                                                               364                                                                               23.391                                                                             49.671                                                                             -3.198                                                                             1.00                                                                              37.99                                        ATOM  2459                                                                              CD2 TYR                                                                               364                                                                               24.280                                                                             47.047                                                                             -3.380                                                                             1.00                                                                              33.35                                        ATOM  2460                                                                              CE2 TYR                                                                               364                                                                               23.152                                                                             47.443                                                                             -4.082                                                                             1.00                                                                              38.54                                        ATOM  2461                                                                              CZ  TYR                                                                               364                                                                               22.717                                                                             48.766                                                                             -3.983                                                                             1.00                                                                              38.50                                        ATOM  2462                                                                              OH  TYR                                                                               364                                                                               21.612                                                                             49.214                                                                             -4.665                                                                             1.00                                                                              45.95                                        ATOM  2463                                                                              C   TYR                                                                               364                                                                               27.522                                                                             46.055                                                                             -0.488                                                                             1.00                                                                              32.98                                        ATOM  2464                                                                              O   TYR                                                                               364                                                                               28.281                                                                             46.720                                                                             0.230                                                                              1.00                                                                              33.48                                        ATOM  2465                                                                              N   VAL                                                                               365                                                                               27.899                                                                             44.898                                                                             -1.005                                                                             1.00                                                                              34.46                                        ATOM  2466                                                                              CA  VAL                                                                               365                                                                               29.266                                                                             44.442                                                                             -0.779                                                                             1.00                                                                              35.26                                        ATOM  2467                                                                              CB  VAL                                                                               365                                                                               29.324                                                                             43.174                                                                             0.132                                                                              1.00                                                                              35.22                                        ATOM  2468                                                                              CG1 VAL                                                                               365                                                                               28.544                                                                             42.064                                                                             -0.479                                                                             1.00                                                                              36.06                                        ATOM  2469                                                                              CG2 VAL                                                                               365                                                                               30.774                                                                             42.761                                                                             0.415                                                                              1.00                                                                              32.31                                        ATOM  2470                                                                              C   VAL                                                                               365                                                                               29.946                                                                             44.221                                                                             -2.124                                                                             1.00                                                                              32.82                                        ATOM  2471                                                                              O   VAL                                                                               365                                                                               29.287                                                                             43.928                                                                             -3.127                                                                             1.00                                                                              29.89                                        ATOM  2472                                                                              N   GLU                                                                               366                                                                               31.239                                                                             44.490                                                                             -2.164                                                                             1.00                                                                              30.38                                        ATOM  2473                                                                              CA  GLU                                                                               366                                                                               32.002                                                                             44.298                                                                             -3.378                                                                             1.00                                                                              34.07                                        ATOM  2474                                                                              CB  GLU                                                                               366                                                                               32.648                                                                             45.606                                                                             -3.814                                                                             1.00                                                                              37.91                                        ATOM  2475                                                                              CG  GLU                                                                               366                                                                               31.688                                                                             46.701                                                                             -4.249                                                                             1.00                                                                              41.21                                        ATOM  2476                                                                              CD  GLU                                                                               366                                                                               32.428                                                                             47.937                                                                             -4.782                                                                             1.00                                                                              43.61                                        ATOM  2477                                                                              OE1 GLU                                                                               366                                                                               31.836                                                                             48.651                                                                             -5.635                                                                             1.00                                                                              40.82                                        ATOM  2478                                                                              OE2 GLU                                                                               366                                                                               33.591                                                                             48.184                                                                             -4.350                                                                             1.00                                                                              37.47                                        ATOM  2479                                                                              C   GLU                                                                               366                                                                               33.104                                                                             43.272                                                                             -3.155                                                                             1.00                                                                              33.05                                        ATOM  2480                                                                              O   GLU                                                                               366                                                                               33.875                                                                             43.392                                                                             -2.194                                                                             1.00                                                                              31.68                                        ATOM  2481                                                                              N   THR                                                                               367                                                                               33.169                                                                             42.261                                                                             -4.021                                                                             1.00                                                                              32.11                                        ATOM  2482                                                                              CA  THR                                                                               367                                                                               34.217                                                                             41.249                                                                             -3.923                                                                             1.00                                                                              31.20                                        ATOM  2483                                                                              CB  THR                                                                               367                                                                               33.687                                                                             39.839                                                                             -3.496                                                                             1.00                                                                              27.61                                        ATOM  2484                                                                              OG1 THR                                                                               367                                                                               32.743                                                                             39.357                                                                             -4.444                                                                             1.00                                                                              28.79                                        ATOM  2485                                                                              CG2 THR                                                                               367                                                                               33.031                                                                             39.876                                                                             -2.120                                                                             1.00                                                                              28.94                                        ATOM  2486                                                                              C   THR                                                                               367                                                                               34.979                                                                             41.142                                                                             -5.241                                                                             1.00                                                                              29.56                                        ATOM  2487                                                                              O   THR                                                                               367                                                                               34.447                                                                             41.405                                                                             -6.310                                                                             1.00                                                                              29.90                                        ATOM  2488                                                                              N   ARG                                                                               368                                                                               36.237                                                                             40.756                                                                             -5.142                                                                             1.00                                                                              31.09                                        ATOM  2489                                                                              CA  ARG                                                                               368                                                                               37.123                                                                             40.604                                                                             -6.284                                                                             1.00                                                                              31.96                                        ATOM  2490                                                                              CB  ARG                                                                               368                                                                               38.379                                                                             41.435                                                                             -6.014                                                                             1.00                                                                              29.37                                        ATOM  2491                                                                              CG  ARG                                                                               368                                                                               39.507                                                                             41.187                                                                             -6.926                                                                             1.00                                                                              34.48                                        ATOM  2492                                                                              CD  ARG                                                                               368                                                                               40.493                                                                             40.266                                                                             -6.273                                                                             1.00                                                                              41.51                                        ATOM  2493                                                                              NE  ARG                                                                               368                                                                               41.404                                                                             39.670                                                                             -7.251                                                                             1.00                                                                              47.48                                        ATOM  2494                                                                              CZ  ARG                                                                               368                                                                               42.269                                                                             40.372                                                                             -7.971                                                                             1.00                                                                              51.99                                        ATOM  2495                                                                              NH1 ARG                                                                               368                                                                               43.070                                                                             39.756                                                                             -8.839                                                                             1.00                                                                              54.18                                        ATOM  2496                                                                              NH2 ARG                                                                               368                                                                               42.336                                                                             41.697                                                                             -7.820                                                                             1.00                                                                              53.93                                        ATOM  2497                                                                              C   ARG                                                                               368                                                                               37.451                                                                             39.109                                                                             -6.444                                                                             1.00                                                                              33.34                                        ATOM  2498                                                                              O   ARG                                                                               368                                                                               37.763                                                                             38.436                                                                             -5.464                                                                             1.00                                                                              34.00                                        ATOM  2499                                                                              N   PRO                                                                               369                                                                               37.391                                                                             38.580                                                                             -7.680                                                                             1.00                                                                              34.18                                        ATOM  2500                                                                              CD  PRO                                                                               369                                                                               37.115                                                                             39.364                                                                             -8.888                                                                             1.00                                                                              33.71                                        ATOM  2501                                                                              CA  PRO                                                                               369                                                                               37.656                                                                             37.186                                                                             -8.054                                                                             1.00                                                                              30.61                                        ATOM  2502                                                                              CB  PRO                                                                               369                                                                               37.481                                                                             37.200                                                                             -9.561                                                                             1.00                                                                              31.74                                        ATOM  2503                                                                              CG  PRO                                                                               369                                                                               36.530                                                                             38.326                                                                             -9.771                                                                             1.00                                                                              35.33                                        ATOM  2504                                                                              C   PRO                                                                               369                                                                               39.044                                                                             36.722                                                                             -7.722                                                                             1.00                                                                              29.83                                        ATOM  2505                                                                              O   PRO                                                                               369                                                                               39.924                                                                             37.525                                                                             -7.398                                                                             1.00                                                                              27.32                                        ATOM  2506                                                                              N   SER                                                                               370                                                                               39.255                                                                             35.417                                                                             -7.836                                                                             1.00                                                                              28.62                                        ATOM  2507                                                                              CA  SER                                                                               370                                                                               40.573                                                                             34.883                                                                             -7.554                                                                             1.00                                                                              31.48                                        ATOM  2508                                                                              CB  SER                                                                               370                                                                               40.546                                                                             33.372                                                                             -7.433                                                                             1.00                                                                              27.56                                        ATOM  2509                                                                              OG  SER                                                                               370                                                                               41.406                                                                             33.022                                                                             -6.370                                                                             1.00                                                                              38.88                                        ATOM  2510                                                                              C   SER                                                                               370                                                                               41.553                                                                             35.358                                                                             -8.632                                                                             1.00                                                                              29.79                                        ATOM  2511                                                                              O   SER                                                                               370                                                                               41.136                                                                             35.864                                                                             -9.680                                                                             1.00                                                                              28.74                                        ATOM  2512                                                                              N   ILE                                                                               371                                                                               42.849                                                                             35.217                                                                             -8.367                                                                             1.00                                                                              29.17                                        ATOM  2513                                                                              CA  ILE                                                                               371                                                                               43.867                                                                             35.686                                                                             -9.297                                                                             1.00                                                                              28.44                                        ATOM  2514                                                                              CB  ILE                                                                               371                                                                               45.288                                                                             35.247                                                                             -8.863                                                                             1.00                                                                              24.69                                        ATOM  2515                                                                              CG2 ILE                                                                               371                                                                               45.532                                                                             33.810                                                                             -9.203                                                                             1.00                                                                              24.58                                        ATOM  2516                                                                              CG1 ILE                                                                               371                                                                               46.322                                                                             36.103                                                                             -9.586                                                                             1.00                                                                              29.48                                        ATOM  2517                                                                              CD1 ILE                                                                               371                                                                               47.658                                                                             36.218                                                                             -8.891                                                                             1.00                                                                              30.22                                        ATOM  2518                                                                              C   ILE                                                                               371                                                                               43.560                                                                             35.358                                                                             -10.778                                                                            1.00                                                                              28.82                                        ATOM  2519                                                                              O   ILE                                                                               371                                                                               43.096                                                                             34.268                                                                             -11.119                                                                            1.00                                                                              28.35                                        ATOM  2520                                                                              N   GLY                                                                               372                                                                               43.745                                                                             36.354                                                                             -11.637                                                                            1.00                                                                              30.09                                        ATOM  2521                                                                              CA  GLY                                                                               372                                                                               43.456                                                                             36.181                                                                             -13.049                                                                            1.00                                                                              34.56                                        ATOM  2522                                                                              C   GLY                                                                               372                                                                               42.236                                                                             36.980                                                                             -13.483                                                                            1.00                                                                              36.19                                        ATOM  2523                                                                              O   GLY                                                                               372                                                                               41.849                                                                             36.930                                                                             -14.640                                                                            1.00                                                                              38.57                                        ATOM  2524                                                                              N   SER                                                                               373                                                                               41.608                                                                             37.689                                                                             -12.549                                                                            1.00                                                                              40.47                                        ATOM  2525                                                                              CA  SER                                                                               373                                                                               40.446                                                                             38.522                                                                             -12.841                                                                            1.00                                                                              41.94                                        ATOM  2526                                                                              CB  SER                                                                               373                                                                               39.187                                                                             37.678                                                                             -12.980                                                                            1.00                                                                              41.45                                        ATOM  2527                                                                              OG  SER                                                                               373                                                                               38.126                                                                             38.476                                                                             -13.463                                                                            1.00                                                                              43.54                                        ATOM  2528                                                                              C   SER                                                                               373                                                                               40.251                                                                             39.574                                                                             -11.752                                                                            1.00                                                                              45.16                                        ATOM  2529                                                                              O   SER                                                                               373                                                                               40.044                                                                             39.266                                                                             -10.570                                                                            1.00                                                                              46.16                                        ATOM  2530                                                                              N   SER                                                                               374                                                                               40.308                                                                             40.828                                                                             -12.157                                                                            1.00                                                                              48.44                                        ATOM  2531                                                                              CA  SER                                                                               374                                                                               40.162                                                                             41.911                                                                             -11.202                                                                            1.00                                                                              53.89                                        ATOM  2532                                                                              CB  SER                                                                               374                                                                               41.048                                                                             43.071                                                                             -11.625                                                                            1.00                                                                              57.08                                        ATOM  2533                                                                              OG  SER                                                                               374                                                                               42.301                                                                             42.578                                                                             -12.055                                                                            1.00                                                                              68.67                                        ATOM  2534                                                                              C   SER                                                                               374                                                                               38.735                                                                             42.392                                                                             -11.070                                                                            1.00                                                                              53.37                                        ATOM  2535                                                                              O   SER                                                                               374                                                                               38.358                                                                             42.931                                                                             -10.033                                                                            1.00                                                                              53.57                                        ATOM  2536                                                                              N   LYS                                                                               375                                                                               37.954                                                                             42.204                                                                             -12.130                                                                            1.00                                                                              53.62                                        ATOM  2537                                                                              CA  LYS                                                                               375                                                                               36.565                                                                             42.646                                                                             -12.165                                                                            1.00                                                                              54.04                                        ATOM  2538                                                                              CB  LYS                                                                               375                                                                               35.804                                                                             41.962                                                                             -13.309                                                                            1.00                                                                              61.15                                        ATOM  2539                                                                              CG  LYS                                                                               375                                                                               35.604                                                                             40.453                                                                             -13.172                                                                            1.00                                                                              71.46                                        ATOM  2540                                                                              CD  LYS                                                                               375                                                                               34.757                                                                             39.912                                                                             -14.328                                                                            1.00                                                                              80.46                                        ATOM  2541                                                                              CE  LYS                                                                               375                                                                               34.547                                                                             38.401                                                                             -14.234                                                                            1.00                                                                              85.39                                        ATOM  2542                                                                              NZ  LYS                                                                               375                                                                               33.824                                                                             37.872                                                                             -15.438                                                                            1.00                                                                              89.61                                        ATOM  2543                                                                              C   LYS                                                                               375                                                                               35.869                                                                             42.386                                                                             -10.847                                                                            1.00                                                                              49.20                                        ATOM  2544                                                                              O   LYS                                                                               375                                                                               35.898                                                                             41.276                                                                             -10.352                                                                            1.00                                                                              49.05                                        ATOM  2545                                                                              N   THR                                                                               376                                                                               35.289                                                                             43.420                                                                             -10.255                                                                            1.00                                                                              45.64                                        ATOM  2546                                                                              CA  THR                                                                               376                                                                               34.614                                                                             43.239                                                                             -8.991                                                                             1.00                                                                              43.45                                        ATOM  2547                                                                              CB  THR                                                                               376                                                                               34.597                                                                             44.516                                                                             -8.122                                                                             1.00                                                                              47.21                                        ATOM  2548                                                                              OG1 THR                                                                               376                                                                               33.898                                                                             45.562                                                                             -8.803                                                                             1.00                                                                              50.56                                        ATOM  2549                                                                              CG2 THR                                                                               376                                                                               36.017                                                                             44.975                                                                             -7.798                                                                             1.00                                                                              48.78                                        ATOM  2550                                                                              C   THR                                                                               376                                                                               33.207                                                                             42.747                                                                             -9.207                                                                             1.00                                                                              40.09                                        ATOM  2551                                                                              O   THR                                                                               376                                                                               32.642                                                                             42.852                                                                             -10.300                                                                            1.00                                                                              35.92                                        ATOM  2552                                                                              N   ILE                                                                               377                                                                               32.656                                                                             42.202                                                                             -8.137                                                                             1.00                                                                              37.93                                        ATOM  2553                                                                              CA  ILE                                                                               377                                                                               31.326                                                                             41.653                                                                             -8.137                                                                             1.00                                                                              36.78                                        ATOM  2554                                                                              CB  ILE                                                                               377                                                                               31.362                                                                             40.152                                                                             -7.774                                                                             1.00                                                                              34.83                                        ATOM  2555                                                                              CG2 ILE                                                                               377                                                                               29.980                                                                             39.533                                                                             -7.895                                                                             1.00                                                                              32.45                                        ATOM  2556                                                                              CG1 ILE                                                                               377                                                                               32.348                                                                             39.413                                                                             -8.684                                                                             1.00                                                                              32.69                                        ATOM  2557                                                                              CD1 ILE                                                                               377                                                                               32.748                                                                             38.041                                                                             -8.162                                                                             1.00                                                                              27.92                                        ATOM  2558                                                                              C   ILE                                                                               377                                                                               30.563                                                                             42.415                                                                             -7.072                                                                             1.00                                                                              39.31                                        ATOM  2559                                                                              O   ILE                                                                               377                                                                               30.962                                                                             42.435                                                                             -5.896                                                                             1.00                                                                              38.63                                        ATOM  2560                                                                              N   THR                                                                               378                                                                               29.566                                                                             43.169                                                                             -7.519                                                                             1.00                                                                              41.06                                        ATOM  2561                                                                              CA  THR                                                                               378                                                                               28.712                                                                             43.918                                                                             -6.616                                                                             1.00                                                                              40.06                                        ATOM  2562                                                                              CB  THR                                                                               378                                                                               28.209                                                                             45.243                                                                             -7.226                                                                             1.00                                                                              38.28                                        ATOM  2563                                                                              OG1 THR                                                                               378                                                                               29.316                                                                             46.145                                                                             -7.396                                                                             1.00                                                                              43.42                                        ATOM  2564                                                                              CG2 THR                                                                               378                                                                               27.163                                                                             45.891                                                                             -6.308                                                                             1.00                                                                              36.99                                        ATOM  2565                                                                              C   THR                                                                               378                                                                               27.536                                                                             42.999                                                                             -6.323                                                                             1.00                                                                              40.53                                        ATOM  2566                                                                              O   THR                                                                               378                                                                               27.024                                                                             42.310                                                                             -7.214                                                                             1.00                                                                              42.82                                        ATOM  2567                                                                              N   SER                                                                               379                                                                               27.153                                                                             42.959                                                                             -5.054                                                                             1.00                                                                              41.66                                        ATOM  2568                                                                              CA  SER                                                                               379                                                                               26.057                                                                             42.122                                                                             -4.585                                                                             1.00                                                                              37.15                                        ATOM  2569                                                                              CB  SER                                                                               379                                                                               26.315                                                                             41.774                                                                             -3.123                                                                             1.00                                                                              39.90                                        ATOM  2570                                                                              OG  SER                                                                               379                                                                               26.357                                                                             42.971                                                                             -2.344                                                                             1.00                                                                              39.97                                        ATOM  2571                                                                              C   SER                                                                               379                                                                               24.738                                                                             42.872                                                                             -4.640                                                                             1.00                                                                              34.85                                        ATOM  2572                                                                              O   SER                                                                               379                                                                               24.689                                                                             44.089                                                                             -4.869                                                                             1.00                                                                              34.30                                        ATOM  2573                                                                              N   PRO                                                                               380                                                                               23.638                                                                             42.148                                                                             -4.448                                                                             1.00                                                                              30.97                                        ATOM  2574                                                                              CD  PRO                                                                               380                                                                               23.467                                                                             40.702                                                                             -4.256                                                                             1.00                                                                              30.83                                        ATOM  2575                                                                              CA  PRO                                                                               380                                                                               22.355                                                                             42.837                                                                             -4.467                                                                             1.00                                                                              31.60                                        ATOM  2576                                                                              CB  PRO                                                                               380                                                                               21.355                                                                             41.692                                                                             -4.253                                                                             1.00                                                                              33.86                                        ATOM  2577                                                                              CG  PRO                                                                               380                                                                               22.064                                                                             40.484                                                                             -4.705                                                                             1.00                                                                              29.90                                        ATOM  2578                                                                              C   PRO                                                                               380                                                                               22.365                                                                             43.725                                                                             -3.219                                                                             1.00                                                                              31.83                                        ATOM  2579                                                                              O   PRO                                                                               380                                                                               23.212                                                                             43.544                                                                             -2.338                                                                             1.00                                                                              34.52                                        ATOM  2580                                                                              N   PHE                                                                               381                                                                               21.469                                                                             44.700                                                                             -3.144                                                                             1.00                                                                              31.79                                        ATOM  2581                                                                              CA  PHE                                                                               381                                                                               21.399                                                                             45.514                                                                             -1.940                                                                             1.00                                                                              30.64                                        ATOM  2582                                                                              CB  PHE                                                                               381                                                                               20.547                                                                             46.761                                                                             -2.152                                                                             1.00                                                                              26.26                                        ATOM  2583                                                                              CG  PHE                                                                               381                                                                               20.422                                                                             47.617                                                                             -0.932                                                                             1.00                                                                              24.77                                        ATOM  2584                                                                              CD1 PHE                                                                               381                                                                               21.530                                                                             48.333                                                                             -0.452                                                                             1.00                                                                              26.36                                        ATOM  2585                                                                              CD2 PHE                                                                               381                                                                               19.198                                                                             47.712                                                                             -0.258                                                                             1.00                                                                              21.71                                        ATOM  2586                                                                              CE1 PHE                                                                               381                                                                               21.431                                                                             49.137                                                                             0.684                                                                              1.00                                                                              25.19                                        ATOM  2587                                                                              CE2 PHE                                                                               381                                                                               19.073                                                                             48.501                                                                             0.872                                                                              1.00                                                                              21.85                                        ATOM  2588                                                                              CZ  PHE                                                                               381                                                                               20.201                                                                             49.224                                                                             1.353                                                                              1.00                                                                              27.79                                        ATOM  2589                                                                              C   PHE                                                                               381                                                                               20.751                                                                             44.613                                                                             -0.881                                                                             1.00                                                                              32.40                                        ATOM  2590                                                                              O   PHE                                                                               381                                                                               19.861                                                                             43.801                                                                             -1.185                                                                             1.00                                                                              32.67                                        ATOM  2591                                                                              N   TYR                                                                               382                                                                               21.225                                                                             44.746                                                                             0.351                                                                              1.00                                                                              34.10                                        ATOM  2592                                                                              CA  TYR                                                                               382                                                                               20.732                                                                             43.974                                                                             1.485                                                                              1.00                                                                              30.09                                        ATOM  2593                                                                              CB  TYR                                                                               382                                                                               21.890                                                                             43.185                                                                             2.083                                                                              1.00                                                                              22.37                                        ATOM  2594                                                                              CG  TYR                                                                               382                                                                               22.562                                                                             42.226                                                                             1.140                                                                              1.00                                                                              15.64                                        ATOM  2595                                                                              CD1 TYR                                                                               382                                                                               23.940                                                                             42.249                                                                             0.959                                                                              1.00                                                                              19.25                                        ATOM  2596                                                                              CE1 TYR                                                                               382                                                                               24.576                                                                             41.299                                                                             0.181                                                                              1.00                                                                              17.01                                        ATOM  2597                                                                              CD2 TYR                                                                               382                                                                               21.835                                                                             41.237                                                                             0.501                                                                              1.00                                                                              21.74                                        ATOM  2598                                                                              CE2 TYR                                                                               382                                                                               22.457                                                                             40.278                                                                             -0.286                                                                             1.00                                                                              17.61                                        ATOM  2599                                                                              CZ  TYR                                                                               382                                                                               23.822                                                                             40.315                                                                             -0.436                                                                             1.00                                                                              20.73                                        ATOM  2600                                                                              OH  TYR                                                                               382                                                                               24.406                                                                             39.331                                                                             -1.176                                                                             1.00                                                                              22.81                                        ATOM  2601                                                                              C   TYR                                                                               382                                                                               20.220                                                                             44.975                                                                             2.530                                                                              1.00                                                                              33.35                                        ATOM  2602                                                                              O   TYR                                                                               382                                                                               20.899                                                                             45.969                                                                             2.818                                                                              1.00                                                                              34.99                                        ATOM  2603                                                                              N   GLY                                                                               383                                                                               19.014                                                                             44.748                                                                             3.051                                                                              1.00                                                                              32.94                                        ATOM  2604                                                                              CA  GLY                                                                               383                                                                               18.457                                                                             45.635                                                                             4.064                                                                              1.00                                                                              32.92                                        ATOM  2605                                                                              C   GLY                                                                               383                                                                               17.707                                                                             46.853                                                                             3.548                                                                              1.00                                                                              35.30                                        ATOM  2606                                                                              O   GLY                                                                               383                                                                               17.148                                                                             46.820                                                                             2.454                                                                              1.00                                                                              32.00                                        ATOM  2607                                                                              N   ASP                                                                               384                                                                               17.694                                                                             47.916                                                                             4.354                                                                              1.00                                                                              34.45                                        ATOM  2608                                                                              CA  ASP                                                                               384                                                                               17.015                                                                             49.159                                                                             4.027                                                                              1.00                                                                              33.27                                        ATOM  2609                                                                              CB  ASP                                                                               384                                                                               16.294                                                                             49.698                                                                             5.241                                                                              1.00                                                                              36.97                                        ATOM  2610                                                                              CG  ASP                                                                               384                                                                               14.987                                                                             49.003                                                                             5.484                                                                              1.00                                                                              41.84                                        ATOM  2611                                                                              OD1 ASP                                                                               384                                                                               14.110                                                                             49.050                                                                             4.590                                                                              1.00                                                                              48.37                                        ATOM  2612                                                                              OD2 ASP                                                                               384                                                                               14.828                                                                             48.418                                                                             6.568                                                                              1.00                                                                              42.67                                        ATOM  2613                                                                              C   ASP                                                                               384                                                                               17.936                                                                             50.224                                                                             3.531                                                                              1.00                                                                              35.10                                        ATOM  2614                                                                              O   ASP                                                                               384                                                                               19.068                                                                             50.319                                                                             3.998                                                                              1.00                                                                              34.64                                        ATOM  2615                                                                              N   LYS                                                                               385                                                                               17.447                                                                             51.020                                                                             2.577                                                                              1.00                                                                              39.67                                        ATOM  2616                                                                              CA  LYS                                                                               385                                                                               18.212                                                                             52.128                                                                             1.969                                                                              1.00                                                                              42.47                                        ATOM  2617                                                                              CB  LYS                                                                               385                                                                               17.461                                                                             52.731                                                                             0.766                                                                              1.00                                                                              49.42                                        ATOM  2618                                                                              CG  LYS                                                                               385                                                                               17.308                                                                             51.805                                                                             -0.432                                                                             1.00                                                                              57.29                                        ATOM  2619                                                                              CD  LYS                                                                               385                                                                               18.609                                                                             51.672                                                                             -1.254                                                                             1.00                                                                              63.49                                        ATOM  2620                                                                              CE  LYS                                                                               385                                                                               18.395                                                                             50.774                                                                             -2.495                                                                             1.00                                                                              67.56                                        ATOM  2621                                                                              NZ  LYS                                                                               385                                                                               19.579                                                                             50.684                                                                             -3.406                                                                             1.00                                                                              67.31                                        ATOM  2622                                                                              C   LYS                                                                               385                                                                               18.442                                                                             53.219                                                                             2.993                                                                              1.00                                                                              39.12                                        ATOM  2623                                                                              O   LYS                                                                               385                                                                               17.573                                                                             53.470                                                                             3.838                                                                              1.00                                                                              43.51                                        ATOM  2624                                                                              N   SER                                                                               386                                                                               19.559                                                                             53.931                                                                             2.901                                                                              1.00                                                                              34.02                                        ATOM  2625                                                                              CA  SER                                                                               386                                                                               19.771                                                                             54.934                                                                             3.913                                                                              1.00                                                                              34.23                                        ATOM  2626                                                                              CB  SER                                                                               386                                                                               21.246                                                                             55.265                                                                             4.156                                                                              1.00                                                                              27.24                                        ATOM  2627                                                                              OG  SER                                                                               386                                                                               21.916                                                                             55.575                                                                             2.988                                                                              1.00                                                                              29.42                                        ATOM  2628                                                                              C   SER                                                                               386                                                                               18.928                                                                             56.164                                                                             3.825                                                                              1.00                                                                              39.30                                        ATOM  2629                                                                              O   SER                                                                               386                                                                               18.289                                                                             56.441                                                                             2.814                                                                              1.00                                                                              45.39                                        ATOM  2630                                                                              N   THR                                                                               387                                                                               18.847                                                                             56.790                                                                             4.994                                                                              1.00                                                                              44.75                                        ATOM  2631                                                                              CA  THR                                                                               387                                                                               18.126                                                                             58.011                                                                             5.334                                                                              1.00                                                                              43.08                                        ATOM  2632                                                                              CB  THR                                                                               387                                                                               17.432                                                                             57.749                                                                             6.690                                                                              1.00                                                                              45.54                                        ATOM  2633                                                                              OG1 THR                                                                               387                                                                               16.146                                                                             57.160                                                                             6.456                                                                              1.00                                                                              51.56                                        ATOM  2634                                                                              CG2 THR                                                                               387                                                                               17.365                                                                             58.983                                                                             7.581                                                                              1.00                                                                              48.46                                        ATOM  2635                                                                              C   THR                                                                               387                                                                               19.219                                                                             59.058                                                                             5.509                                                                              1.00                                                                              41.51                                        ATOM  2636                                                                              O   THR                                                                               387                                                                               19.060                                                                             60.229                                                                             5.207                                                                              1.00                                                                              45.34                                        ATOM  2637                                                                              N   GLU                                                                               388                                                                               20.372                                                                             58.578                                                                             5.945                                                                              1.00                                                                              39.65                                        ATOM  2638                                                                              CA  GLU                                                                               388                                                                               21.510                                                                             59.408                                                                             6.192                                                                              1.00                                                                              40.13                                        ATOM  2639                                                                              CB  GLU                                                                               388                                                                               22.079                                                                             58.996                                                                             7.537                                                                              1.00                                                                              42.68                                        ATOM  2640                                                                              CG  GLU                                                                               388                                                                               21.079                                                                             59.112                                                                             8.646                                                                              1.00                                                                              46.20                                        ATOM  2641                                                                              CD  GLU                                                                               388                                                                               20.744                                                                             60.555                                                                             8.979                                                                              1.00                                                                              51.34                                        ATOM  2642                                                                              OE1 GLU                                                                               388                                                                               21.607                                                                             61.454                                                                             8.749                                                                              1.00                                                                              48.83                                        ATOM  2643                                                                              OE2 GLU                                                                               388                                                                               19.615                                                                             60.789                                                                             9.496                                                                              1.00                                                                              54.12                                        ATOM  2644                                                                              C   GLU                                                                               388                                                                               22.554                                                                             59.136                                                                             5.115                                                                              1.00                                                                              40.71                                        ATOM  2645                                                                              O   GLU                                                                               388                                                                               22.342                                                                             58.275                                                                             4.252                                                                              1.00                                                                              39.83                                        ATOM  2646                                                                              N   PRO                                                                               389                                                                               23.702                                                                             59.825                                                                             5.183                                                                              1.00                                                                              42.10                                        ATOM  2647                                                                              CD  PRO                                                                               389                                                                               24.063                                                                             60.916                                                                             6.114                                                                              1.00                                                                              42.78                                        ATOM  2648                                                                              CA  PRO                                                                               389                                                                               24.763                                                                             59.619                                                                             4.198                                                                              1.00                                                                              44.35                                        ATOM  2649                                                                              CB  PRO                                                                               389                                                                               25.851                                                                             60.608                                                                             4.654                                                                              1.00                                                                              45.07                                        ATOM  2650                                                                              CG  PRO                                                                               389                                                                               25.090                                                                             61.684                                                                             5.323                                                                              1.00                                                                              43.93                                        ATOM  2651                                                                              C   PRO                                                                               389                                                                               25.311                                                                             58.169                                                                             4.187                                                                              1.00                                                                              45.36                                        ATOM  2652                                                                              O   PRO                                                                               389                                                                               25.363                                                                             57.489                                                                             5.234                                                                              1.00                                                                              46.15                                        ATOM  2653                                                                              N   VAL                                                                               390                                                                               25.717                                                                             57.715                                                                             3.003                                                                              1.00                                                                              42.43                                        ATOM  2654                                                                              CA  VAL                                                                               390                                                                               26.286                                                                             56.379                                                                             2.838                                                                              1.00                                                                              39.18                                        ATOM  2655                                                                              CB  VAL                                                                               390                                                                               26.062                                                                             55.818                                                                             1.444                                                                              1.00                                                                              33.17                                        ATOM  2656                                                                              CG1 VAL                                                                               390                                                                               24.593                                                                             55.549                                                                             1.257                                                                              1.00                                                                              35.38                                        ATOM  2657                                                                              CG2 VAL                                                                               390                                                                               26.586                                                                             56.788                                                                             0.395                                                                              1.00                                                                              35.87                                        ATOM  2658                                                                              C   VAL                                                                               390                                                                               27.766                                                                             56.466                                                                             3.077                                                                              1.00                                                                              41.43                                        ATOM  2659                                                                              O   VAL                                                                               390                                                                               28.384                                                                             57.471                                                                             2.713                                                                              1.00                                                                              42.32                                        ATOM  2660                                                                              N   GLN                                                                               391                                                                               28.310                                                                             55.434                                                                             3.726                                                                              1.00                                                                              44.86                                        ATOM  2661                                                                              CA  GLN                                                                               391                                                                               29.739                                                                             55.358                                                                             4.638                                                                              1.00                                                                              47.38                                        ATOM  2662                                                                              CB  GLN                                                                               391                                                                               29.982                                                                             55.249                                                                             5.559                                                                              1.00                                                                              49.86                                        ATOM  2663                                                                              CG  GLN                                                                               391                                                                               29.536                                                                             56.490                                                                             6.359                                                                              1.00                                                                              50.20                                        ATOM  2664                                                                              CD  GLN                                                                               391                                                                               29.613                                                                             56.298                                                                             7.868                                                                              1.00                                                                              53.83                                        ATOM  2665                                                                              OE1 GLN                                                                               391                                                                               30.599                                                                             55.765                                                                             8.384                                                                              1.00                                                                              52.70                                        ATOM  2666                                                                              NE2 GLN                                                                               391                                                                               28.575                                                                             56.739                                                                             8.583                                                                              1.00                                                                              48.35                                        ATOM  2667                                                                              C   GLN                                                                               391                                                                               30.334                                                                             54.159                                                                             3.299                                                                              1.00                                                                              45.72                                        ATOM  2668                                                                              O   GLN                                                                               391                                                                               29.836                                                                             53.032                                                                             3.392                                                                              1.00                                                                              46.80                                        ATOM  2669                                                                              N   LYS                                                                               392                                                                               31.412                                                                             54.420                                                                             2.571                                                                              1.00                                                                              44.47                                        ATOM  2670                                                                              CA  LYS                                                                               392                                                                               32.071                                                                             53.407                                                                             1.774                                                                              1.00                                                                              40.66                                        ATOM  2671                                                                              CB  LYS                                                                               392                                                                               32.196                                                                             53.911                                                                             0.335                                                                              1.00                                                                              42.32                                        ATOM  2672                                                                              CG  LYS                                                                               392                                                                               32.828                                                                             52.947                                                                             -0.666                                                                             1.00                                                                              48.87                                        ATOM  2673                                                                              CD  LYS                                                                               392                                                                               32.022                                                                             51.647                                                                             -0.844                                                                             1.00                                                                              51.56                                        ATOM  2674                                                                              CE  LYS                                                                               392                                                                               32.284                                                                             50.967                                                                             -2.202                                                                             1.00                                                                              50.35                                        ATOM  2675                                                                              NZ  LYS                                                                               392                                                                               31.718                                                                             51.738                                                                             -3.365                                                                             1.00                                                                              53.19                                        ATOM  2676                                                                              C   LYS                                                                               392                                                                               33.439                                                                             53.116                                                                             2.328                                                                              1.00                                                                              38.02                                        ATOM  2677                                                                              O   LYS                                                                               392                                                                               34.230                                                                             54.024                                                                             2.578                                                                              1.00                                                                              40.88                                        ATOM  2678                                                                              N   LEU                                                                               393                                                                               33.692                                                                             51.839                                                                             2.562                                                                              1.00                                                                              35.52                                        ATOM  2679                                                                              CA  LEU                                                                               393                                                                               34.978                                                                             51.395                                                                             3.052                                                                              1.00                                                                              33.95                                        ATOM  2680                                                                              CB  LEU                                                                               393                                                                               34.827                                                                             50.700                                                                             4.404                                                                              1.00                                                                              30.25                                        ATOM  2681                                                                              CG  LEU                                                                               393                                                                               34.497                                                                             51.594                                                                             5.596                                                                              1.00                                                                              30.20                                        ATOM  2682                                                                              CD1 LEU                                                                               393                                                                               34.535                                                                             50.778                                                                             6.890                                                                              1.00                                                                              32.88                                        ATOM  2683                                                                              CD2 LEU                                                                               393                                                                               35.506                                                                             52.722                                                                             5.664                                                                              1.00                                                                              31.84                                        ATOM  2684                                                                              C   LEU                                                                               393                                                                               35.528                                                                             50.418                                                                             2.014                                                                              1.00                                                                              34.73                                        ATOM  2685                                                                              O   LEU                                                                               393                                                                               34.796                                                                             49.539                                                                             1.543                                                                              1.00                                                                              36.19                                        ATOM  2686                                                                              N   SER                                                                               394                                                                               36.780                                                                             50.620                                                                             1.614                                                                              1.00                                                                              31.82                                        ATOM  2687                                                                              CA  SER                                                                               394                                                                               37.430                                                                             49.747                                                                             0.652                                                                              1.00                                                                              37.44                                        ATOM  2688                                                                              CB  SER                                                                               394                                                                               37.971                                                                             50.516                                                                             -0.541                                                                             1.00                                                                              41.95                                        ATOM  2689                                                                              OG  SER                                                                               394                                                                               38.489                                                                             49.617                                                                             -1.521                                                                             1.00                                                                              50.00                                        ATOM  2690                                                                              C   SER                                                                               394                                                                               38.591                                                                             49.051                                                                             1.312                                                                              1.00                                                                              39.64                                        ATOM  2691                                                                              O   SER                                                                               394                                                                               39.512                                                                             49.695                                                                             1.835                                                                              1.00                                                                              42.33                                        ATOM  2692                                                                              N   PHE                                                                               395                                                                               38.567                                                                             47.733                                                                             1.248                                                                              1.00                                                                              37.33                                        ATOM  2693                                                                              CA  PHE                                                                               395                                                                               39.605                                                                             46.933                                                                             1.846                                                                              1.00                                                                              39.32                                        ATOM  2694                                                                              CB  PHE                                                                               395                                                                               38.963                                                                             45.836                                                                             2.682                                                                              1.00                                                                              34.54                                        ATOM  2695                                                                              CG  PHE                                                                               395                                                                               37.909                                                                             46.337                                                                             3.615                                                                              1.00                                                                              32.96                                        ATOM  2696                                                                              CD1 PHE                                                                               395                                                                               36.563                                                                             46.226                                                                             3.278                                                                              1.00                                                                              25.90                                        ATOM  2697                                                                              CD2 PHE                                                                               395                                                                               38.258                                                                             46.916                                                                             4.835                                                                              1.00                                                                              30.10                                        ATOM  2698                                                                              CE1 PHE                                                                               395                                                                               35.575                                                                             46.678                                                                             4.138                                                                              1.00                                                                              25.06                                        ATOM  2699                                                                              CE2 PHE                                                                               395                                                                               37.270                                                                             47.376                                                                             5.708                                                                              1.00                                                                              31.10                                        ATOM  2700                                                                              CZ  PHE                                                                               395                                                                               35.921                                                                             47.255                                                                             5.356                                                                              1.00                                                                              27.26                                        ATOM  2701                                                                              C   PHE                                                                               395                                                                               40.555                                                                             46.333                                                                             0.818                                                                              1.00                                                                              42.66                                        ATOM  2702                                                                              O   PHE                                                                               395                                                                               41.275                                                                             45.388                                                                             1.127                                                                              1.00                                                                              43.59                                        ATOM  2703                                                                              N   ASP                                                                               396                                                                               40.544                                                                             46.858                                                                             -0.404                                                                             1.00                                                                              44.49                                        ATOM  2704                                                                              CA  ASP                                                                               396                                                                               41.434                                                                             46.355                                                                             -1.449                                                                             1.00                                                                              46.90                                        ATOM  2705                                                                              CB  ASP                                                                               396                                                                               41.338                                                                             47.261                                                                             -2.693                                                                             1.00                                                                              49.42                                        ATOM  2706                                                                              CG  ASP                                                                               396                                                                               42.396                                                                             46.935                                                                             -3.764                                                                             1.00                                                                              55.28                                        ATOM  2707                                                                              OD1 ASP                                                                               396                                                                               42.247                                                                             45.919                                                                             -4.494                                                                             1.00                                                                              54.98                                        ATOM  2708                                                                              OD2 ASP                                                                               396                                                                               43.374                                                                             47.717                                                                             -3.884                                                                             1.00                                                                              56.58                                        ATOM  2709                                                                              C   ASP                                                                               396                                                                               42.879                                                                             46.293                                                                             -0.914                                                                             1.00                                                                              48.42                                        ATOM  2710                                                                              O   ASP                                                                               396                                                                               43.417                                                                             47.308                                                                             -0.452                                                                             1.00                                                                              51.13                                        ATOM  2711                                                                              N   GLY                                                                               397                                                                               43.465                                                                             45.093                                                                             -0.908                                                                             1.00                                                                              47.37                                        ATOM  2712                                                                              CA  GLY                                                                               397                                                                               44.836                                                                             44.908                                                                             -0.437                                                                             1.00                                                                              49.02                                        ATOM  2713                                                                              C   GLY                                                                               397                                                                               45.040                                                                             44.597                                                                             1.045                                                                              1.00                                                                              49.20                                        ATOM  2714                                                                              O   GLY                                                                               397                                                                               46.155                                                                             44.290                                                                             1.497                                                                              1.00                                                                              50.80                                        ATOM  2715                                                                              N   GLN                                                                               398                                                                               43.949                                                                             44.642                                                                             1.797                                                                              1.00                                                                              48.76                                        ATOM  2716                                                                              CA  GLN                                                                               398                                                                               43.973                                                                             44.402                                                                             3.229                                                                              1.00                                                                              43.09                                        ATOM  2717                                                                              CB  GLN                                                                               398                                                                               43.194                                                                             45.515                                                                             3.957                                                                              1.00                                                                              42.33                                        ATOM  2718                                                                              CG  GLN                                                                               398                                                                               43.622                                                                             46.937                                                                             3.625                                                                              1.00                                                                              40.39                                        ATOM  2719                                                                              CD  GLN                                                                               398                                                                               45.056                                                                             47.224                                                                             4.023                                                                              1.00                                                                              41.78                                        ATOM  2720                                                                              OE1 GLN                                                                               398                                                                               45.473                                                                             46.965                                                                             5.149                                                                              1.00                                                                              40.33                                        ATOM  2721                                                                              NE2 GLN                                                                               398                                                                               45.827                                                                             47.747                                                                             3.088                                                                              1.00                                                                              46.48                                        ATOM  2722                                                                              C   GLN                                                                               398                                                                               43.353                                                                             43.051                                                                             3.576                                                                              1.00                                                                              39.37                                        ATOM  2723                                                                              O   GLN                                                                               398                                                                               42.579                                                                             42.480                                                                             2.793                                                                              1.00                                                                              35.23                                        ATOM  2724                                                                              N   LYS                                                                               399                                                                               43.741                                                                             42.535                                                                             4.740                                                                              1.00                                                                              36.01                                        ATOM  2725                                                                              CA  LYS                                                                               399                                                                               43.220                                                                             41.283                                                                             5.271                                                                              1.00                                                                              32.45                                        ATOM  2726                                                                              CB  LYS                                                                               399                                                                               44.354                                                                             40.298                                                                             5.627                                                                              1.00                                                                              32.95                                        ATOM  2727                                                                              CG  LYS                                                                               399                                                                               45.153                                                                             39.758                                                                             4.467                                                                              1.00                                                                              35.89                                        ATOM  2728                                                                              CD  LYS                                                                               399                                                                               44.318                                                                             38.913                                                                             3.525                                                                              1.00                                                                              45.68                                        ATOM  2729                                                                              CE  LYS                                                                               399                                                                               45.157                                                                             38.442                                                                             2.309                                                                              1.00                                                                              55.14                                        ATOM  2730                                                                              NZ  LYS                                                                               399                                                                               44.438                                                                             37.617                                                                             1.261                                                                              1.00                                                                              52.03                                        ATOM  2731                                                                              C   LYS                                                                               399                                                                               42.506                                                                             41.712                                                                             6.558                                                                              1.00                                                                              28.99                                        ATOM  2732                                                                              O   LYS                                                                               399                                                                               43.163                                                                             42.099                                                                             7.528                                                                              1.00                                                                              27.89                                        ATOM  2733                                                                              N   VAL                                                                               400                                                                               41.178                                                                             41.713                                                                             6.547                                                                              1.00                                                                              21.30                                        ATOM  2734                                                                              CA  VAL                                                                               400                                                                               40.433                                                                             42.091                                                                             7.736                                                                              1.00                                                                              22.51                                        ATOM  2735                                                                              CB  VAL                                                                               400                                                                               39.005                                                                             42.610                                                                             7.399                                                                              1.00                                                                              23.45                                        ATOM  2736                                                                              CG1 VAL                                                                               400                                                                               38.225                                                                             42.938                                                                             8.675                                                                              1.00                                                                              17.30                                        ATOM  2737                                                                              CG2 VAL                                                                               400                                                                               39.120                                                                             43.846                                                                             6.543                                                                              1.00                                                                              22.17                                        ATOM  2738                                                                              C   VAL                                                                               400                                                                               40.385                                                                             40.895                                                                             8.666                                                                              1.00                                                                              20.47                                        ATOM  2739                                                                              O   VAL                                                                               400                                                                               39.623                                                                             39.965                                                                             8.464                                                                              1.00                                                                              20.32                                        ATOM  2740                                                                              N   TYR                                                                               401                                                                               41.177                                                                             40.946                                                                             9.718                                                                              1.00                                                                              22.08                                        ATOM  2741                                                                              CA  TYR                                                                               401                                                                               41.235                                                                             39.832                                                                             10.626                                                                             1.00                                                                              23.87                                        ATOM  2742                                                                              CB  TYR                                                                               401                                                                               42.686                                                                             39.513                                                                             10.967                                                                             1.00                                                                              23.92                                        ATOM  2743                                                                              CG  TYR                                                                               401                                                                               43.399                                                                             40.624                                                                             11.667                                                                             1.00                                                                              21.62                                        ATOM  2744                                                                              CD1 TYR                                                                               401                                                                               43.361                                                                             40.718                                                                             13.049                                                                             1.00                                                                              23.62                                        ATOM  2745                                                                              CE1 TYR                                                                               401                                                                               44.024                                                                             41.725                                                                             13.718                                                                             1.00                                                                              22.25                                        ATOM  2746                                                                              CD2 TYR                                                                               401                                                                               44.124                                                                             41.583                                                                             10.949                                                                             1.00                                                                              23.09                                        ATOM  2747                                                                              CE2 TYR                                                                               401                                                                               44.791                                                                             42.607                                                                             11.602                                                                             1.00                                                                              21.21                                        ATOM  2748                                                                              CZ  TYR                                                                               401                                                                               44.733                                                                             42.663                                                                             12.995                                                                             1.00                                                                              26.42                                        ATOM  2749                                                                              OH  TYR                                                                               401                                                                               45.392                                                                             43.644                                                                             13.698                                                                             1.00                                                                              38.32                                        ATOM  2750                                                                              C   TYR                                                                               401                                                                               40.421                                                                             39.971                                                                             11.886                                                                             1.00                                                                              25.97                                        ATOM  2751                                                                              O   TYR                                                                               401                                                                               40.523                                                                             39.117                                                                             12.762                                                                             1.00                                                                              24.72                                        ATOM  2752                                                                              N   ARG                                                                               402                                                                               39.627                                                                             41.033                                                                             11.999                                                                             1.00                                                                              25.45                                        ATOM  2753                                                                              CA  ARG                                                                               402                                                                               38.797                                                                             41.206                                                                             13.181                                                                             1.00                                                                              21.27                                        ATOM  2754                                                                              CB  ARG                                                                               402                                                                               39.671                                                                             41.438                                                                             14.397                                                                             1.00                                                                              20.74                                        ATOM  2755                                                                              CG  ARG                                                                               402                                                                               38.922                                                                             41.510                                                                             15.687                                                                             1.00                                                                              19.16                                        ATOM  2756                                                                              CD  ARG                                                                               402                                                                               39.831                                                                             42.048                                                                             16.720                                                                             1.00                                                                              16.61                                        ATOM  2757                                                                              NE  ARG                                                                               402                                                                               39.323                                                                             41.788                                                                             18.050                                                                             1.00                                                                              24.94                                        ATOM  2758                                                                              CZ  ARG                                                                               402                                                                               40.054                                                                             41.922                                                                             19.154                                                                             1.00                                                                              34.52                                        ATOM  2759                                                                              NH1 ARG                                                                               402                                                                               39.521                                                                             41.650                                                                             20.337                                                                             1.00                                                                              40.04                                        ATOM  2760                                                                              NH2 ARG                                                                               402                                                                               41.314                                                                             42.347                                                                             19.081                                                                             1.00                                                                              29.20                                        ATOM  2761                                                                              C   ARG                                                                               402                                                                               37.794                                                                             42.340                                                                             13.079                                                                             1.00                                                                              22.04                                        ATOM  2762                                                                              O   ARG                                                                               402                                                                               38.103                                                                             43.401                                                                             12.539                                                                             1.00                                                                              21.07                                        ATOM  2763                                                                              N   THR                                                                               403                                                                               36.622                                                                             42.113                                                                             13.670                                                                             1.00                                                                              23.72                                        ATOM  2764                                                                              CA  THR                                                                               403                                                                               35.519                                                                             43.062                                                                             13.702                                                                             1.00                                                                              22.58                                        ATOM  2765                                                                              CB  THR                                                                               403                                                                               34.395                                                                             42.681                                                                             12.701                                                                             1.00                                                                              26.34                                        ATOM  2766                                                                              OG1 THR                                                                               403                                                                               33.865                                                                             41.394                                                                             13.027                                                                             1.00                                                                              31.05                                        ATOM  2767                                                                              CG2 THR                                                                               403                                                                               34.930                                                                             42.618                                                                             11.297                                                                             1.00                                                                              28.24                                        ATOM  2768                                                                              C   THR                                                                               403                                                                               34.942                                                                             43.074                                                                             15.111                                                                             1.00                                                                              19.93                                        ATOM  2769                                                                              O   THR                                                                               403                                                                               34.810                                                                             42.033                                                                             15.751                                                                             1.00                                                                              17.31                                        ATOM  2770                                                                              N   ILE                                                                               404                                                                               34.672                                                                             44.274                                                                             15.603                                                                             1.00                                                                              21.50                                        ATOM  2771                                                                              CA  ILE                                                                               404                                                                               34.117                                                                             44.490                                                                             16.941                                                                             1.00                                                                              23.42                                        ATOM  2772                                                                              CB  ILE                                                                               404                                                                               35.139                                                                             45.177                                                                             17.888                                                                             1.00                                                                              22.26                                        ATOM  2773                                                                              CG2 ILE                                                                               404                                                                               34.511                                                                             45.385                                                                             19.290                                                                             1.00                                                                              25.17                                        ATOM  2774                                                                              CG1 ILE                                                                               404                                                                               36.436                                                                             44.355                                                                             17.945                                                                             1.00                                                                              19.77                                        ATOM  2775                                                                              CD1 ILE                                                                               404                                                                               37.514                                                                             44.953                                                                             18.807                                                                             1.00                                                                              19.18                                        ATOM  2776                                                                              C   ILE                                                                               404                                                                               32.952                                                                             45.431                                                                             16.738                                                                             1.00                                                                              22.13                                        ATOM  2777                                                                              O   ILE                                                                               404                                                                               33.123                                                                             46.554                                                                             16.251                                                                             1.00                                                                              20.52                                        ATOM  2778                                                                              N   ALA                                                                               405                                                                               31.769                                                                             44.967                                                                             17.091                                                                             1.00                                                                              24.23                                        ATOM  2779                                                                              CA  ALA                                                                               405                                                                               30.566                                                                             45.761                                                                             16.903                                                                             1.00                                                                              29.85                                        ATOM  2780                                                                              CB  ALA                                                                               405                                                                               29.505                                                                             44.951                                                                             16.164                                                                             1.00                                                                              32.90                                        ATOM  2781                                                                              C   ALA                                                                               405                                                                               29.998                                                                             46.268                                                                             18.196                                                                             1.00                                                                              30.65                                        ATOM  2782                                                                              O   ALA                                                                               405                                                                               30.172                                                                             45.654                                                                             19.261                                                                             1.00                                                                              32.26                                        ATOM  2783                                                                              N   ASN                                                                               406                                                                               29.314                                                                             47.401                                                                             18.086                                                                             1.00                                                                              33.60                                        ATOM  2784                                                                              CA  ASN                                                                               406                                                                               28.657                                                                             48.036                                                                             19.213                                                                             1.00                                                                              30.90                                        ATOM  2785                                                                              CB  ASN                                                                               406                                                                               29.353                                                                             49.328                                                                             19.575                                                                             1.00                                                                              35.26                                        ATOM  2786                                                                              CG  ASN                                                                               406                                                                               30.688                                                                             49.082                                                                             20.251                                                                             1.00                                                                              39.28                                        ATOM  2787                                                                              OD1 ASN                                                                               406                                                                               31.716                                                                             49.567                                                                             19.796                                                                             1.00                                                                              46.28                                        ATOM  2788                                                                              ND2 ASN                                                                               406                                                                               30.677                                                                             48.323                                                                             21.345                                                                             1.00                                                                              41.47                                        ATOM  2789                                                                              C   ASN                                                                               406                                                                               27.221                                                                             48.255                                                                             18.823                                                                             1.00                                                                              27.42                                        ATOM  2790                                                                              O   ASN                                                                               406                                                                               26.917                                                                             48.549                                                                             17.680                                                                             1.00                                                                              31.60                                        ATOM  2791                                                                              N   THR                                                                               407                                                                               26.335                                                                             48.093                                                                             19.779                                                                             1.00                                                                              28.95                                        ATOM  2792                                                                              CA  THR                                                                               407                                                                               24.923                                                                             48.210                                                                             19.527                                                                             1.00                                                                              27.59                                        ATOM  2793                                                                              CB  THR                                                                               407                                                                               24.307                                                                             46.799                                                                             19.792                                                                             1.00                                                                              29.44                                        ATOM  2794                                                                              OG1 THR                                                                               407                                                                               23.752                                                                             46.264                                                                             18.585                                                                             1.00                                                                              34.58                                        ATOM  2795                                                                              CG2 THR                                                                               407                                                                               23.274                                                                             46.801                                                                             20.891                                                                             1.00                                                                              32.65                                        ATOM  2796                                                                              C   THR                                                                               407                                                                               24.312                                                                             49.344                                                                             20.376                                                                             1.00                                                                              29.05                                        ATOM  2797                                                                              O   THR                                                                               407                                                                               25.039                                                                             50.103                                                                             21.043                                                                             1.00                                                                              29.87                                        ATOM  2798                                                                              N   ASP                                                                               408                                                                               22.994                                                                             49.517                                                                             20.272                                                                             1.00                                                                              30.18                                        ATOM  2799                                                                              CA  ASP                                                                               408                                                                               22.248                                                                             50.520                                                                             21.040                                                                             1.00                                                                              26.65                                        ATOM  2800                                                                              CB  ASP                                                                               408                                                                               22.396                                                                             51.893                                                                             20.417                                                                             1.00                                                                              26.06                                        ATOM  2801                                                                              CG  ASP                                                                               408                                                                               22.171                                                                             53.004                                                                             21.396                                                                             1.00                                                                              28.54                                        ATOM  2802                                                                              OD1 ASP                                                                               408                                                                               22.823                                                                             54.054                                                                             21.232                                                                             1.00                                                                              32.74                                        ATOM  2803                                                                              OD2 ASP                                                                               408                                                                               21.362                                                                             52.841                                                                             22.322                                                                             1.00                                                                              22.44                                        ATOM  2804                                                                              C   ASP                                                                               408                                                                               20.777                                                                             50.102                                                                             21.089                                                                             1.00                                                                              25.70                                        ATOM  2805                                                                              O   ASP                                                                               408                                                                               20.375                                                                             49.156                                                                             20.412                                                                             1.00                                                                              26.95                                        ATOM  2806                                                                              N   VAL                                                                               409                                                                               19.998                                                                             50.740                                                                             21.949                                                                             1.00                                                                              26.74                                        ATOM  2807                                                                              CA  VAL                                                                               409                                                                               18.579                                                                             50.416                                                                             22.096                                                                             1.00                                                                              29.52                                        ATOM  2808                                                                              CB  VAL                                                                               409                                                                               18.318                                                                             49.460                                                                             23.308                                                                             1.00                                                                              33.88                                        ATOM  2809                                                                              CG1 VAL                                                                               409                                                                               18.152                                                                             48.015                                                                             22.865                                                                             1.00                                                                              32.06                                        ATOM  2810                                                                              CG2 VAL                                                                               409                                                                               19.450                                                                             49.583                                                                             24.330                                                                             1.00                                                                              36.32                                        ATOM  2811                                                                              C   VAL                                                                               409                                                                               17.750                                                                             51.675                                                                             22.354                                                                             1.00                                                                              29.41                                        ATOM  2812                                                                              O   VAL                                                                               409                                                                               18.284                                                                             52.726                                                                             22.744                                                                             1.00                                                                              27.31                                        ATOM  2813                                                                              N   ALA                                                                               410                                                                               16.438                                                                             51.524                                                                             22.174                                                                             1.00                                                                              28.05                                        ATOM  2814                                                                              CA  ALA                                                                               410                                                                               15.450                                                                             52.573                                                                             22.397                                                                             1.00                                                                              21.88                                        ATOM  2815                                                                              CB  ALA                                                                               410                                                                               15.244                                                                             53.387                                                                             21.135                                                                             1.00                                                                              18.08                                        ATOM  2816                                                                              C   ALA                                                                               410                                                                               14.196                                                                             51.772                                                                             22.734                                                                             1.00                                                                              22.70                                        ATOM  2817                                                                              O   ALA                                                                               410                                                                               13.674                                                                             51.018                                                                             21.905                                                                             1.00                                                                              19.65                                        ATOM  2818                                                                              N   ALA                                                                               411                                                                               13.805                                                                             51.820                                                                             24.003                                                                             1.00                                                                              27.52                                        ATOM  2819                                                                              CA  ALA                                                                               411                                                                               12.623                                                                             51.091                                                                             24.470                                                                             1.00                                                                              31.81                                        ATOM  2820                                                                              CB  ALA                                                                               411                                                                               12.873                                                                             50.502                                                                             25.829                                                                             1.00                                                                              33.93                                        ATOM  2821                                                                              C   ALA                                                                               411                                                                               11.431                                                                             52.029                                                                             24.525                                                                             1.00                                                                              34.20                                        ATOM  2822                                                                              O   ALA                                                                               411                                                                               11.535                                                                             53.147                                                                             25.038                                                                             1.00                                                                              34.95                                        ATOM  2823                                                                              N   TRP                                                                               412                                                                               10.306                                                                             51.592                                                                             23.987                                                                             1.00                                                                              33.77                                        ATOM  2824                                                                              CA  TRP                                                                               412                                                                               9.134                                                                              52.436                                                                             23.996                                                                             1.00                                                                              39.98                                        ATOM  2825                                                                              CB  TRP                                                                               412                                                                               8.392                                                                              52.358                                                                             22.669                                                                             1.00                                                                              41.61                                        ATOM  2826                                                                              CG  TRP                                                                               412                                                                               9.054                                                                              53.098                                                                             21.571                                                                             1.00                                                                              43.46                                        ATOM  2827                                                                              CD2 TRP                                                                               412                                                                               8.430                                                                              53.596                                                                             20.392                                                                             1.00                                                                              45.56                                        ATOM  2828                                                                              CE2 TRP                                                                               412                                                                               9.440                                                                              54.195                                                                             19.607                                                                             1.00                                                                              42.47                                        ATOM  2829                                                                              CE3 TRP                                                                               412                                                                               7.110                                                                              53.590                                                                             19.916                                                                             1.00                                                                              46.54                                        ATOM  2830                                                                              CD1 TRP                                                                               412                                                                               10.376                                                                             53.412                                                                             21.467                                                                             1.00                                                                              44.40                                        ATOM  2831                                                                              NE1 TRP                                                                               412                                                                               10.617                                                                             54.067                                                                             20.288                                                                             1.00                                                                              43.38                                        ATOM  2832                                                                              CZ2 TRP                                                                               412                                                                               9.177                                                                              54.788                                                                             18.377                                                                             1.00                                                                              45.51                                        ATOM  2833                                                                              CZ3 TRP                                                                               412                                                                               6.844                                                                              54.179                                                                             18.689                                                                             1.00                                                                              46.75                                        ATOM  2834                                                                              CH2 TRP                                                                               412                                                                               7.877                                                                              54.770                                                                             17.931                                                                             1.00                                                                              48.56                                        ATOM  2835                                                                              C   TRP                                                                               412                                                                               8.213                                                                              52.038                                                                             25.114                                                                             1.00                                                                              44.25                                        ATOM  2836                                                                              O   TRP                                                                               412                                                                               8.109                                                                              50.853                                                                             25.444                                                                             1.00                                                                              42.52                                        ATOM  2837                                                                              N   PRO                                                                               413                                                                               7.519                                                                              53.028                                                                             25.716                                                                             1.00                                                                              50.07                                        ATOM  2838                                                                              CD  PRO                                                                               413                                                                               7.624                                                                              54.477                                                                             25.453                                                                             1.00                                                                              50.83                                        ATOM  2839                                                                              CA  PRO                                                                               413                                                                               6.584                                                                              52.781                                                                             26.815                                                                             1.00                                                                              50.92                                        ATOM  2840                                                                              CB  PRO                                                                               413                                                                               5.903                                                                              54.138                                                                             26.979                                                                             1.00                                                                              50.26                                        ATOM  2841                                                                              CG  PRO                                                                               413                                                                               7.019                                                                              55.079                                                                             26.697                                                                             1.00                                                                              49.66                                        ATOM  2842                                                                              C   PRO                                                                               413                                                                               5.599                                                                              51.690                                                                             26.424                                                                             1.00                                                                              51.13                                        ATOM  2843                                                                              O   PRO                                                                               413                                                                               5.244                                                                              50.846                                                                             27.240                                                                             1.00                                                                              53.47                                        ATOM  2844                                                                              N   ASN                                                                               414                                                                               5.227                                                                              51.674                                                                             25.148                                                                             1.00                                                                              52.31                                        ATOM  2845                                                                              CA  ASN                                                                               414                                                                               4.291                                                                              50.687                                                                             24.624                                                                             1.00                                                                              54.17                                        ATOM  2846                                                                              CB  ASN                                                                               414                                                                               3.559                                                                              51.238                                                                             23.388                                                                             1.00                                                                              58.82                                        ATOM  2847                                                                              CG  ASN                                                                               414                                                                               4.490                                                                              51.960                                                                             22.411                                                                             1.00                                                                              61.33                                        ATOM  2848                                                                              OD1 ASN                                                                               414                                                                               4.680                                                                              53.184                                                                             22.501                                                                             1.00                                                                              64.05                                        ATOM  2849                                                                              ND2 ASN                                                                               414                                                                               5.073                                                                              51.210                                                                             21.480                                                                             1.00                                                                              55.75                                        ATOM  2850                                                                              C   ASN                                                                               414                                                                               4.947                                                                              49.338                                                                             24.321                                                                             1.00                                                                              54.03                                        ATOM  2851                                                                              O   ASN                                                                               414                                                                               4.481                                                                              48.586                                                                             23.466                                                                             1.00                                                                              55.84                                        ATOM  2852                                                                              N   GLY                                                                               415                                                                               6.058                                                                              49.060                                                                             24.992                                                                             1.00                                                                              51.36                                        ATdM  2853                                                                              CA  GLY                                                                               415                                                                               6.737                                                                              47.792                                                                             24.811                                                                             1.00                                                                              50.33                                        ATOM  2854                                                                              C   GLY                                                                               415                                                                               7.639                                                                              47.544                                                                             23.614                                                                             1.00                                                                              49.60                                        ATOM  2855                                                                              O   GLY                                                                               415                                                                               8.402                                                                              46.582                                                                             23.616                                                                             1.00                                                                              55.05                                        ATOM  2856                                                                              N   LYS                                                                               416                                                                               7.578                                                                              48.375                                                                             22.591                                                                             1.00                                                                              46.50                                        ATOM  2857                                                                              CA  LYS                                                                               416                                                                               8.423                                                                              48.147                                                                             21.431                                                                             1.00                                                                              43.10                                        ATOM  2858                                                                              CB  LYS                                                                               416                                                                               7.982                                                                              49.065                                                                             20.294                                                                             1.00                                                                              45.88                                        ATOM  2859                                                                              CG  LYS                                                                               416                                                                               6.489                                                                              49.015                                                                             19.988                                                                             1.00                                                                              48.22                                        ATOM  2860                                                                              CD  LYS                                                                               416                                                                               6.139                                                                              47.815                                                                             19.142                                                                             1.00                                                                              53.88                                        ATOM  2861                                                                              CE  LYS                                                                               416                                                                               4.658                                                                              47.762                                                                             18.779                                                                             1.00                                                                              53.22                                        ATOM  2862                                                                              NZ  LYS                                                                               416                                                                               4.374                                                                              46.692                                                                             17.766                                                                             1.00                                                                              54.21                                        ATOM  2863                                                                              C   LYS                                                                               416                                                                               9.887                                                                              48.429                                                                             21.775                                                                             1.00                                                                              39.40                                        ATOM  2864                                                                              O   LYS                                                                               416                                                                               10.197                                                                             49.492                                                                             22.311                                                                             1.00                                                                              39.18                                        ATOM  2865                                                                              N   VAL                                                                               417                                                                               10.771                                                                             47.453                                                                             21.571                                                                             1.00                                                                              36.07                                        ATOM  2866                                                                              CA  VAL                                                                               417                                                                               12.198                                                                             47.682                                                                             21.818                                                                             1.00                                                                              33.10                                        ATOM  2867                                                                              CB  VAL                                                                               417                                                                               12.851                                                                             46.648                                                                             22.748                                                                             1.00                                                                              32.27                                        ATOM  2868                                                                              CG1 VAL                                                                               417                                                                               14.357                                                                             46.934                                                                             22.860                                                                             1.00                                                                              29.20                                        ATOM  2869                                                                              CG2 VAL                                                                               417                                                                               12.234                                                                             46.738                                                                             24.127                                                                             1.00                                                                              30.38                                        ATOM  2870                                                                              C   VAL                                                                               417                                                                               12.893                                                                             47.682                                                                             20.469                                                                             1.00                                                                              33.32                                        ATOM  2871                                                                              O   VAL                                                                               417                                                                               12.521                                                                             46.923                                                                             19.558                                                                             1.00                                                                              32.49                                        ATOM  2872                                                                              N   TYR                                                                               418                                                                               13.877                                                                             48.562                                                                             20.332                                                                             1.00                                                                              32.46                                        ATOM  2873                                                                              CA  TYR                                                                               418                                                                               14.584                                                                             48.700                                                                             19.078                                                                             1.00                                                                              30.70                                        ATOM  2874                                                                              CB  TYR                                                                               418                                                                               14.201                                                                             50.034                                                                             18.430                                                                             1.00                                                                              35.09                                        ATOM  2875                                                                              CG  TYR                                                                               418                                                                               12.723                                                                             50.142                                                                             18.087                                                                             1.00                                                                              39.67                                        ATOM  2876                                                                              CD1 TYR                                                                               418                                                                               11.830                                                                             50.796                                                                             18.939                                                                             1.00                                                                              41.36                                        ATOM  2877                                                                              CE1 TYR                                                                               418                                                                               10.468                                                                             50.837                                                                             18.656                                                                             1.00                                                                              41.55                                        ATOM  2878                                                                              CD2 TYR                                                                               418                                                                               12.210                                                                             49.539                                                                             16.938                                                                             1.00                                                                              42.74                                        ATOM  2879                                                                              CE2 TYR                                                                               418                                                                               10.858                                                                             49.579                                                                             16.649                                                                             1.00                                                                              41.49                                        ATOM  2880                                                                              CZ  TYR                                                                               418                                                                               9.997                                                                              50.224                                                                             17.512                                                                             1.00                                                                              40.58                                        ATOM  2881                                                                              OH  TYR                                                                               418                                                                               8.660                                                                              50.227                                                                             17.231                                                                             1.00                                                                              43.39                                        ATOM  2882                                                                              C   TYR                                                                               418                                                                               16.087                                                                             48.604                                                                             19.217                                                                             1.00                                                                              31.90                                        ATOM  2883                                                                              O   TYR                                                                               418                                                                               16.674                                                                             49.292                                                                             20.050                                                                             1.00                                                                              34.09                                        ATOM  2884                                                                              N   LEU                                                                               419                                                                               16.697                                                                             47.794                                                                             18.349                                                                             1.00                                                                              35.53                                        ATOM  2885                                                                              CA  LEU                                                                               419                                                                               18.145                                                                             47.575                                                                             18.313                                                                             1.00                                                                              35.73                                        ATOM  2886                                                                              CB  LEU                                                                               419                                                                               18.470                                                                             46.188                                                                             18.875                                                                             1.00                                                                              40.81                                        ATOM  2887                                                                              CG  LEU                                                                               419                                                                               18.374                                                                             46.005                                                                             20.396                                                                             1.00                                                                              45.56                                        ATOM  2888                                                                              CD1 LEU                                                                               419                                                                               17.661                                                                             44.692                                                                             20.771                                                                             1.00                                                                              47.76                                        ATOM  2889                                                                              CD2 LEU                                                                               419                                                                               19.783                                                                             46.064                                                                             20.993                                                                             1.00                                                                              47.90                                        ATOM  2890                                                                              C   LEU                                                                               419                                                                               18.739                                                                             47.717                                                                             16.898                                                                             1.00                                                                              34.04                                        ATOM  2891                                                                              O   LEU                                                                               419                                                                               18.017                                                                             47.650                                                                             15.889                                                                             1.00                                                                              34.32                                        ATOM  2892                                                                              N   GLY                                                                               420                                                                               20.049                                                                             47.940                                                                             16.841                                                                             1.00                                                                              29.29                                        ATOM  2893                                                                              CA  GLY                                                                               420                                                                               20.743                                                                             48.085                                                                             15.576                                                                             1.00                                                                              26.65                                        ATOM  2894                                                                              C   GLY                                                                               420                                                                               22.211                                                                             48.353                                                                             15.836                                                                             1.00                                                                              27.14                                        ATOM  2895                                                                              O   GLY                                                                               420                                                                               22.575                                                                             48.680                                                                             16.964                                                                             1.00                                                                              28.38                                        ATOM  2896                                                                              N   VAL                                                                               421                                                                               23.046                                                                             48.253                                                                             14.803                                                                             1.00                                                                              26.69                                        ATOM  2897                                                                              CA  VAL                                                                               421                                                                               24.490                                                                             48.452                                                                             14.924                                                                             1.00                                                                              24.73                                        ATOM  2898                                                                              CB  VAL                                                                               421                                                                               25.274                                                                             47.527                                                                             13.945                                                                             1.00                                                                              26.82                                        ATOM  2899                                                                              CG1 VAL                                                                               421                                                                               26.784                                                                             47.789                                                                             14.031                                                                             1.00                                                                              25.39                                        ATOM  2900                                                                              CG2 VAL                                                                               421                                                                               24.993                                                                             46.080                                                                             14.252                                                                             1.00                                                                              23.09                                        ATOM  2901                                                                              C   VAL                                                                               421                                                                               24.878                                                                             49.893                                                                             14.640                                                                             1.00                                                                              27.15                                        ATOM  2902                                                                              O   VAL                                                                               421                                                                               24.661                                                                             50.401                                                                             13.539                                                                             1.00                                                                              30.83                                        ATOM  2903                                                                              N   THR                                                                               422                                                                               25.535                                                                             50.521                                                                             15.606                                                                             1.00                                                                              27.69                                        ATOM  2904                                                                              CA  THR                                                                               422                                                                               25.946                                                                             51.910                                                                             15.470                                                                             1.00                                                                              28.13                                        ATOM  2905                                                                              CB  THR                                                                               422                                                                               25.717                                                                             52.692                                                                             16.789                                                                             1.00                                                                              27.76                                        ATOM  2906                                                                              OG1 THR                                                                               422                                                                               26.642                                                                             52.239                                                                             17.782                                                                             1.00                                                                              26.20                                        ATOM  2907                                                                              CG2 THR                                                                               422                                                                               24.285                                                                             52.503                                                                             17.289                                                                             1.00                                                                              22.77                                        ATOM  2908                                                                              C   THR                                                                               422                                                                               27.414                                                                             52.047                                                                             15.133                                                                             1.00                                                                              29.17                                        ATOM  2909                                                                              O   THR                                                                               422                                                                               27.864                                                                             53.111                                                                             14.726                                                                             1.00                                                                              31.06                                        ATOM  2910                                                                              N   LYS                                                                               423                                                                               28.167                                                                             50.974                                                                             15.315                                                                             1.00                                                                              31.17                                        ATOM  2911                                                                              CA  LYS                                                                               423                                                                               29.591                                                                             51.032                                                                             15.079                                                                             1.00                                                                              30.80                                        ATOM  2912                                                                              CB  LYS                                                                               423                                                                               30.242                                                                             51.794                                                                             16.234                                                                             1.00                                                                              27.04                                        ATOM  2913                                                                              CG  LYS                                                                               423                                                                               31.689                                                                             52.148                                                                             16.020                                                                             1.00                                                                              27.11                                        ATOM  2914                                                                              CD  LYS                                                                               423                                                                               32.186                                                                             52.755                                                                             17.273                                                                             1.00                                                                              31.47                                        ATOM  2915                                                                              CE  LYS                                                                               423                                                                               33.668                                                                             52.750                                                                             17.356                                                                             1.00                                                                              32.44                                        ATOM  2916                                                                              NZ  LYS                                                                               423                                                                               33.955                                                                             53.029                                                                             18.792                                                                             1.00                                                                              43.38                                        ATOM  2917                                                                              C   LYS                                                                               423                                                                               30.247                                                                             49.662                                                                             14.914                                                                             1.00                                                                              31.76                                        ATOM  2918                                                                              O   LYS                                                                               423                                                                               29.828                                                                             48.662                                                                             15.529                                                                             1.00                                                                              32.10                                        ATOM  2919                                                                              N   VAL                                                                               424                                                                               31.240                                                                             49.629                                                                             14.026                                                                             1.00                                                                              31.62                                        ATOM  2920                                                                              CA  VAL                                                                               424                                                                               32.015                                                                             48.435                                                                             13.715                                                                             1.00                                                                              30.00                                        ATOM  2921                                                                              CB  VAL                                                                               424                                                                               31.408                                                                             47.626                                                                             12.543                                                                             1.00                                                                              26.10                                        ATOM  2922                                                                              CG1 VAL                                                                               424                                                                               32.157                                                                             46.316                                                                             12.382                                                                             1.00                                                                              24.90                                        ATOM  2923                                                                              CG2 VAL                                                                               424                                                                               29.915                                                                             47.367                                                                             12.769                                                                             1.00                                                                              23.72                                        ATOM  2924                                                                              C   VAL                                                                               424                                                                               33.430                                                                             48.856                                                                             13.329                                                                             1.00                                                                              29.28                                        ATOM  2925                                                                              O   VAL                                                                               424                                                                               33.622                                                                             49.766                                                                             12.524                                                                             1.00                                                                              29.28                                        ATOM  2926                                                                              N   ASP                                                                               425                                                                               34.409                                                                             48.247                                                                             13.984                                                                             1.00                                                                              32.53                                        ATOM  2927                                                                              CA  ASP                                                                               425                                                                               35.816                                                                             48.508                                                                             13.720                                                                             1.00                                                                              32.64                                        ATOM  2928                                                                              CB  ASP                                                                               425                                                                               36.598                                                                             48.641                                                                             15.021                                                                             1.00                                                                              34.95                                        ATOM  2929                                                                              CG  ASP                                                                               425                                                                               36.257                                                                             49.900                                                                             15.769                                                                             1.00                                                                              45.99                                        ATOM  2930                                                                              OD1 ASP                                                                               425                                                                               36.132                                                                             50.961                                                                             15.117                                                                             1.00                                                                              46.60                                        ATOM  2931                                                                              OD2 ASP                                                                               425                                                                               36.107                                                                             49.828                                                                             17.010                                                                             1.00                                                                              52.51                                        ATOM  2932                                                                              C   ASP                                                                               425                                                                               36.369                                                                             47.329                                                                             12.954                                                                             1.00                                                                              30.71                                        ATOM  2933                                                                              O   ASP                                                                               425                                                                               36.189                                                                             46.176                                                                             13.364                                                                             1.00                                                                              28.66                                        ATOM  2934                                                                              N   PHE                                                                               426                                                                               37.035                                                                             47.619                                                                             11.845                                                                             1.00                                                                              30.44                                        ATOM  2935                                                                              CA  PHE                                                                               426                                                                               37.641                                                                             46.599                                                                             11.003                                                                             1.00                                                                              27.35                                        ATOM  2936                                                                              CB  PHE                                                                               426                                                                               37.265                                                                             46.824                                                                             9.533                                                                              1.00                                                                              23.83                                        ATOM  2937                                                                              CG  PHE                                                                               426                                                                               35.811                                                                             46.617                                                                             9.260                                                                              1.00                                                                              22.42                                        ATOM  2938                                                                              CD1 PHE                                                                               426                                                                               34.917                                                                             47.675                                                                             9.353                                                                              1.00                                                                              29.21                                        ATOM  2939                                                                              CD2 PHE                                                                               426                                                                               35.325                                                                             45.356                                                                             8.952                                                                              1.00                                                                              23.84                                        ATOM  2940                                                                              CE1 PHE                                                                               426                                                                               33.535                                                                             47.482                                                                             9.143                                                                              1.00                                                                              30.42                                        ATOM  2941                                                                              CE2 PHE                                                                               426                                                                               33.953                                                                             45.141                                                                             8.738                                                                              1.00                                                                              28.45                                        ATOM  2942                                                                              CZ  PHE                                                                               426                                                                               33.054                                                                             46.211                                                                             8.836                                                                              1.00                                                                              25.84                                        ATOM  2943                                                                              C   PHE                                                                               426                                                                               39.143                                                                             46.651                                                                             11.169                                                                             1.00                                                                              27.60                                        ATOM  2944                                                                              O   PHE                                                                               426                                                                               39.764                                                                             47.605                                                                             10.719                                                                             1.00                                                                              30.18                                        ATOM  2945                                                                              N   SER                                                                               427                                                                               39.704                                                                             45.697                                                                             11.914                                                                             1.00                                                                              28.92                                        ATOM  2946                                                                              CA  SER                                                                               427                                                                               41.159                                                                             45.613                                                                             12.097                                                                             1.00                                                                              31.13                                        ATOM  2947                                                                              CB  SER                                                                               427                                                                               41.527                                                                             44.834                                                                             13.354                                                                             1.00                                                                              23.47                                        ATOM  2948                                                                              OG  SER                                                                               427                                                                               41.323                                                                             45.630                                                                             14.488                                                                             1.00                                                                              34.58                                        ATOM  2949                                                                              C   SER                                                                               427                                                                               41.734                                                                             44.896                                                                             10.885                                                                             1.00                                                                              30.97                                        ATOM  2950                                                                              O   SER                                                                               427                                                                               41.582                                                                             43.678                                                                             10.741                                                                             1.00                                                                              34.75                                        ATOM  2951                                                                              N   GLN                                                                               428                                                                               42.388                                                                             45.647                                                                             10.019                                                                             1.00                                                                              32.50                                        ATOM  2952                                                                              CA  GLN                                                                               428                                                                               42.943                                                                             45.068                                                                             8.819                                                                              1.00                                                                              34.39                                        ATOM  2953                                                                              CB  GLN                                                                               428                                                                               42.474                                                                             45.849                                                                             7.597                                                                              1.00                                                                              35.19                                        ATOM  2954                                                                              CG  GLN                                                                               428                                                                               42.655                                                                             47.358                                                                             7.703                                                                              1.00                                                                              36.26                                        ATOM  2955                                                                              CD  GLN                                                                               428                                                                               41.875                                                                             48.109                                                                             6.636                                                                              1.00                                                                              37.21                                        ATOM  2956                                                                              OE1 GLN                                                                               428                                                                               40.922                                                                             47.576                                                                             6.041                                                                              1.00                                                                              37.62                                        ATOM  2957                                                                              NE2 GLN                                                                               428                                                                               42.263                                                                             49.357                                                                             6.395                                                                              1.00                                                                              37.30                                        ATOM  2958                                                                              C   GLN                                                                               428                                                                               44.445                                                                             45.024                                                                             8.895                                                                              1.00                                                                              34.53                                        ATOM  2959                                                                              O   GLN                                                                               428                                                                               45.047                                                                             45.761                                                                             9.658                                                                              1.00                                                                              32.24                                        ATOM  2960                                                                              N   TYR                                                                               429                                                                               45.026                                                                             44.081                                                                             8.168                                                                              1.00                                                                              39.80                                        ATOM  2961                                                                              CA  TYR                                                                               429                                                                               46.465                                                                             43.909                                                                             8.113                                                                              1.00                                                                              43.52                                        ATOM  2962                                                                              CB  TYR                                                                               429                                                                               46.867                                                                             42.578                                                                             8.733                                                                              1.00                                                                              45.24                                        ATOM  2963                                                                              CG  TYR                                                                               429                                                                               48.340                                                                             42.256                                                                             8.618                                                                              1.00                                                                              44.33                                        ATOM  2964                                                                              CD1 TYR                                                                               429                                                                               49.285                                                                             42.965                                                                             9.350                                                                              1.00                                                                              44.13                                        ATOM  2965                                                                              CE1 TYR                                                                               429                                                                               50.647                                                                             42.652                                                                             9.270                                                                              1.00                                                                              46.61                                        ATOM  2966                                                                              CD2 TYR                                                                               429                                                                               48.784                                                                             41.222                                                                             7.794                                                                              1.00                                                                              45.15                                        ATOM  2967                                                                              CE2 TYR                                                                               429                                                                               50.135                                                                             40.897                                                                             7.709                                                                              1.00                                                                              48.28                                        ATOM  2968                                                                              CZ  TYR                                                                               429                                                                               51.064                                                                             41.614                                                                             8.451                                                                              1.00                                                                              48.90                                        ATOM  2969                                                                              OH  TYR                                                                               429                                                                               52.400                                                                             41.271                                                                             8.405                                                                              1.00                                                                              49.66                                        ATOM  2970                                                                              C   TYR                                                                               429                                                                               46.905                                                                             43.961                                                                             6.653                                                                              1.00                                                                              48.69                                        ATOM  2971                                                                              O   TYR                                                                               429                                                                               46.203                                                                             43.476                                                                             5.759                                                                              1.00                                                                              46.50                                        ATOM  2972                                                                              N   ASP                                                                               430                                                                               48.069                                                                             44.560                                                                             6.431                                                                              1.00                                                                              54.63                                        ATOM  2973                                                                              CA  ASP                                                                               430                                                                               48.649                                                                             44.716                                                                             5.112                                                                              1.00                                                                              58.67                                        ATOM  2974                                                                              CB  ASP                                                                               430                                                                               49.064                                                                             46.175                                                                             4.942                                                                              1.00                                                                              58.82                                        ATOM  2975                                                                              CG  ASP                                                                               430                                                                               49.474                                                                             46.522                                                                             3.518                                                                              1.00                                                                              63.70                                        ATOM  2976                                                                              OD1 ASP                                                                               430                                                                               49.781                                                                             45.612                                                                             2.709                                                                              1.00                                                                              62.99                                        ATOM  2977                                                                              OD2 ASP                                                                               430                                                                               49.494                                                                             47.737                                                                             3.211                                                                              1.00                                                                              65.11                                        ATOM  2978                                                                              C   ASP                                                                               430                                                                               49.874                                                                             43.798                                                                             5.015                                                                              1.00                                                                              63.15                                        ATOM  2979                                                                              O   ASP                                                                               430                                                                               50.820                                                                             43.932                                                                             5.790                                                                              1.00                                                                              62.58                                        ATOM  2980                                                                              N   ASP                                                                               431                                                                               49.846                                                                             42.865                                                                             4.065                                                                              1.00                                                                              69.35                                        ATOM  2981                                                                              CA  ASP                                                                               431                                                                               50.951                                                                             41.916                                                                             3.852                                                                              1.00                                                                              74.25                                        ATOM  2982                                                                              CB  ASP                                                                               431                                                                               50.578                                                                             40.849                                                                             2.802                                                                              1.00                                                                              78.72                                        ATOM  2983                                                                              CG  ASP                                                                               431                                                                               49.404                                                                             39.965                                                                             3.231                                                                              1.00                                                                              83.39                                        ATOM  2984                                                                              OD1 ASP                                                                               431                                                                               49.588                                                                             39.108                                                                             4.127                                                                              1.00                                                                              86.73                                        ATOM  2985                                                                              OD2 ASP                                                                               431                                                                               48.299                                                                             40.117                                                                             2.657                                                                              1.00                                                                              85.57                                        ATOM  2986                                                                              C   ASP                                                                               431                                                                               52.189                                                                             42.659                                                                             3.365                                                                              1.00                                                                              74.94                                        ATOM  2987                                                                              O   ASP                                                                               431                                                                               53.265                                                                             42.526                                                                             3.937                                                                              1.00                                                                              74.05                                        ATOM  2988                                                                              N   GLN                                                                               432                                                                               52.006                                                                             43.437                                                                             2.300                                                                              1.00                                                                              77.50                                        ATOM  2989                                                                              CA  GLN                                                                               432                                                                               53.067                                                                             44.230                                                                             1.683                                                                              1.00                                                                              78.85                                        ATOM  2990                                                                              CB  GLN                                                                               432                                                                               52.469                                                                             45.250                                                                             0.709                                                                              1.00                                                                              84.24                                        ATOM  2991                                                                              CG  GLN                                                                               432                                                                               52.081                                                                             44.770                                                                             -0.664                                                                             1.00                                                                              94.21                                        ATOM  2992                                                                              CD  GLN                                                                               432                                                                               51.874                                                                             45.945                                                                             -1.635                                                                             1.00                                                                              101.21                                       ATOM  2993                                                                              OE1 GLN                                                                               432                                                                               51.963                                                                             45.777                                                                             -2.856                                                                             1.00                                                                              102.84                                       ATOM  2994                                                                              NE2 GLN                                                                               432                                                                               51.620                                                                             47.141                                                                             -1.092                                                                             1.00                                                                              103.92                                       ATOM  2995                                                                              C   GLN                                                                               432                                                                               53.875                                                                             45.043                                                                             2.683                                                                              1.00                                                                              76.88                                        ATOM  2996                                                                              O   GLN                                                                               432                                                                               55.015                                                                             44.727                                                                             3.020                                                                              1.00                                                                              75.05                                        ATOM  2997                                                                              N   LYS                                                                               433                                                                               53.245                                                                             46.122                                                                             3.122                                                                              1.00                                                                              74.75                                        ATOM  2998                                                                              CA  LYS                                                                               433                                                                               53.841                                                                             47.075                                                                             4.032                                                                              1.00                                                                              73.23                                        ATOM  2999                                                                              CB  LYS                                                                               433                                                                               53.030                                                                             48.372                                                                             3.965                                                                              1.00                                                                              77.09                                        ATOM  3000                                                                              CG  LYS                                                                               433                                                                               52.809                                                                             48.809                                                                             2.501                                                                              1.00                                                                              82.48                                        ATOM  3001                                                                              CD  LYS                                                                               433                                                                               51.969                                                                             50.069                                                                             2.321                                                                              1.00                                                                              85.49                                        ATOM  3002                                                                              CE  LYS                                                                               433                                                                               51.789                                                                             50.363                                                                             0.828                                                                              1.00                                                                              85.34                                        ATOM  3003                                                                              NZ  LYS                                                                               433                                                                               51.088                                                                             51.648                                                                             0.574                                                                              1.00                                                                              83.39                                        ATOM  3004                                                                              C   LYS                                                                               433                                                                               53.983                                                                             46.549                                                                             5.446                                                                              1.00                                                                              70.28                                        ATOM  3005                                                                              O   LYS                                                                               433                                                                               54.678                                                                             47.139                                                                             6.266                                                                              1.00                                                                              69.41                                        ATOM  3006                                                                              N   ASN                                                                               434                                                                               53.359                                                                             45.409                                                                             5.711                                                                              1.00                                                                              70.07                                        ATOM  3007                                                                              CA  ASN                                                                               434                                                                               53.424                                                                             44.788                                                                             7.026                                                                              1.00                                                                              69.13                                        ATOM  3008                                                                              CB  ASN                                                                               434                                                                               54.833                                                                             44.269                                                                             7.292                                                                              1.00                                                                              72.41                                        ATOM  3009                                                                              CG  ASN                                                                               434                                                                               54.838                                                                             43.081                                                                             8.213                                                                              1.00                                                                              77.33                                        ATOM  3010                                                                              OD1 ASN                                                                               434                                                                               54.802                                                                             43.220                                                                             9.436                                                                              1.00                                                                              80.62                                        ATOM  3011                                                                              ND2 ASN                                                                               434                                                                               54.833                                                                             41.892                                                                             7.631                                                                              1.00                                                                              82.09                                        ATOM  3012                                                                              C   ASN                                                                               434                                                                               53.018                                                                             45.790                                                                             8.099                                                                              1.00                                                                              66.04                                        ATOM  3013                                                                              O   ASN                                                                               434                                                                               53.745                                                                             46.042                                                                             9.055                                                                              1.00                                                                              66.81                                        ATOM  3014                                                                              N   GLU                                                                               435                                                                               51.862                                                                             46.399                                                                             7.896                                                                              1.00                                                                              63.11                                        ATOM  3015                                                                              CA  GLU                                                                               435                                                                               51.339                                                                             47.376                                                                             8.828                                                                              1.00                                                                              60.05                                        ATOM  3016                                                                              CB  GLU                                                                               435                                                                               51.279                                                                             48.762                                                                             8.171                                                                              1.00                                                                              65.39                                        ATOM  3017                                                                              CG  GLU                                                                               435                                                                               50.404                                                                             48.827                                                                             6.908                                                                              1.00                                                                              71.11                                        ATOM  3018                                                                              CD  GLU                                                                               435                                                                               50.166                                                                             50.249                                                                             6.398                                                                              1.00                                                                              76.12                                        ATOM  3019                                                                              OE1 GLU                                                                               435                                                                               51.151                                                                             50.987                                                                             6.158                                                                              1.00                                                                              77.71                                        ATOM  3020                                                                              OE2 GLU                                                                               435                                                                               48.985                                                                             50.623                                                                             6.221                                                                              1.00                                                                              76.57                                        ATOM  3021                                                                              C   GLU                                                                               435                                                                               49.933                                                                             46.940                                                                             9.207                                                                              1.00                                                                              56.46                                        ATOM  3022                                                                              O   GLU                                                                               435                                                                               49.271                                                                             46.226                                                                             8.443                                                                              1.00                                                                              53.33                                        ATOM  3023                                                                              N   THR                                                                               436                                                                               49.513                                                                             47.310                                                                             10.412                                                                             1.00                                                                              52.67                                        ATOM  3024                                                                              CA  THR                                                                               436                                                                               48.172                                                                             47.011                                                                             10.889                                                                             1.00                                                                              48.22                                        ATOM  3025                                                                              CB  THR                                                                               436                                                                               48.180                                                                             46.265                                                                             12.243                                                                             1.00                                                                              49.49                                        ATOM  3026                                                                              OG1 THR                                                                               436                                                                               48.928                                                                             47.011                                                                             13.217                                                                             1.00                                                                              53.64                                        ATOM  3027                                                                              CG2 THR                                                                               436                                                                               48.786                                                                             44.882                                                                             12.074                                                                             1.00                                                                              50.64                                        ATOM  3028                                                                              C   THR                                                                               436                                                                               47.473                                                                             48.358                                                                             11.032                                                                             1.00                                                                              44.20                                        ATOM  3029                                                                              O   THR                                                                               436                                                                               48.120                                                                             49.373                                                                             11.308                                                                             1.00                                                                              43.15                                        ATOM  3030                                                                              N   SER                                                                               437                                                                               46.172                                                                             48.383                                                                             10.784                                                                             1.00                                                                              39.81                                        ATOM  3031                                                                              CA  SER                                                                               437                                                                               45.404                                                                             49.610                                                                             10.876                                                                             1.00                                                                              35.83                                        ATOM  3032                                                                              CB  SER                                                                               437                                                                               45.525                                                                             50.401                                                                             9.567                                                                              1.00                                                                              34.84                                        ATOM  3033                                                                              OG  SER                                                                               437                                                                               45.215                                                                             49.603                                                                             8.430                                                                              1.00                                                                              26.92                                        ATOM  3034                                                                              C   SER                                                                               437                                                                               43.954                                                                             49.262                                                                             11.147                                                                             1.00                                                                              38.35                                        ATOM  3035                                                                              O   SER                                                                               437                                                                               43.571                                                                             48.082                                                                             11.142                                                                             1.00                                                                              40.79                                        ATOM  3036                                                                              N   THR                                                                               438                                                                               43.138                                                                             50.288                                                                             11.354                                                                             1.00                                                                              37.88                                        ATOM  3037                                                                              CA  THR                                                                               438                                                                               41.723                                                                             50.088                                                                             11.618                                                                             1.00                                                                              31.21                                        ATOM  3038                                                                              CB  THR                                                                               438                                                                               41.421                                                                             50.443                                                                             13.091                                                                             1.00                                                                              30.02                                        ATOM  3039                                                                              OG1 THR                                                                               438                                                                               42.206                                                                             49.607                                                                             13.943                                                                             1.00                                                                              33.35                                        ATOM  3040                                                                              CG2 THR                                                                               438                                                                               39.981                                                                             50.224                                                                             13.428                                                                             1.00                                                                              32.55                                        ATOM  3041                                                                              C   THR                                                                               438                                                                               40.909                                                                             50.974                                                                             10.672                                                                             1.00                                                                              31.00                                        ATOM  3042                                                                              O   THR                                                                               438                                                                               41.434                                                                             51.916                                                                             10.084                                                                             1.00                                                                              31.16                                        ATOM  3043                                                                              N   GLU                                                                               439                                                                               39.676                                                                             50.576                                                                             10.416                                                                             1.00                                                                              30.22                                        ATOM  3044                                                                              CA  GLU                                                                               439                                                                               38.768                                                                             51.358                                                                             9.602                                                                              1.00                                                                              34.37                                        ATOM  3045                                                                              CB  GLU                                                                               439                                                                               38.611                                                                             50.789                                                                             8.204                                                                              1.00                                                                              40.27                                        ATOM  3046                                                                              CG  GLU                                                                               439                                                                               39.717                                                                             51.176                                                                             7.242                                                                              1.00                                                                              42.06                                        ATOM  3047                                                                              CD  GLU                                                                               439                                                                               39.296                                                                             50.989                                                                             5.805                                                                              1.00                                                                              40.04                                        ATOM  3048                                                                              OE1 GLU                                                                               439                                                                               39.526                                                                             49.892                                                                             5.232                                                                              1.00                                                                              36.27                                        ATOM  3049                                                                              OE2 GLU                                                                               439                                                                               38.711                                                                             51.952                                                                             5.267                                                                              1.00                                                                              39.88                                        ATOM  3050                                                                              C   GLU                                                                               439                                                                               37.478                                                                             51.222                                                                             10.377                                                                             1.00                                                                              37.64                                        ATOM  3051                                                                              O   GLU                                                                               439                                                                               37.216                                                                             50.158                                                                             10.948                                                                             1.00                                                                              39.86                                        ATOM  3052                                                                              N   THR                                                                               440                                                                               36.614                                                                             52.224                                                                             10.297                                                                             1.00                                                                              37.34                                        ATOM  3053                                                                              CA  THR                                                                               440                                                                               35.409                                                                             52.209                                                                             11.108                                                                             1.00                                                                              34.42                                        ATOM  3054                                                                              CB  THR                                                                               440                                                                               35.649                                                                             53.180                                                                             12.268                                                                             1.00                                                                              35.98                                        ATOM  3055                                                                              OG1 THR                                                                               440                                                                               36.922                                                                             52.904                                                                             12.871                                                                             1.00                                                                              36.26                                        ATOM  3056                                                                              CG2 THR                                                                               440                                                                               34.523                                                                             53.111                                                                             13.294                                                                             1.00                                                                              40.16                                        ATOM  3057                                                                              C   THR                                                                               440                                                                               34.076                                                                             52.624                                                                             10.496                                                                             1.00                                                                              33.02                                        ATOM  3058                                                                              O   THR                                                                               440                                                                               34.012                                                                             53.522                                                                             9.668                                                                              1.00                                                                              32.99                                        ATOM  3059                                                                              N   TYR                                                                               441                                                                               33.005                                                                             51.984                                                                             10.947                                                                             1.00                                                                              34.71                                        ATOM  3060                                                                              CA  TYR                                                                               441                                                                               31.664                                                                             52.382                                                                             10.548                                                                             1.00                                                                              32.57                                        ATOM  3061                                                                              CB  TYR                                                                               441                                                                               30.798                                                                             51.202                                                                             10.102                                                                             1.00                                                                              30.07                                        ATOM  3062                                                                              CG  TYR                                                                               441                                                                               29.315                                                                             51.543                                                                             10.127                                                                             1.00                                                                              30.12                                        ATOM  3063                                                                              CD1 TYR                                                                               441                                                                               28.777                                                                             52.454                                                                             9.222                                                                              1.00                                                                              28.88                                        ATOM  3064                                                                              CE1 TYR                                                                               441                                                                               27.456                                                                             52.877                                                                             9.325                                                                              1.00                                                                              29.33                                        ATOM  3065                                                                              CD2 TYR                                                                               441                                                                               28.478                                                                             51.046                                                                             11.135                                                                             1.00                                                                              29.87                                        ATOM  3066                                                                              CE2 TYR                                                                               441                                                                               27.164                                                                             51.462                                                                             11.245                                                                             1.00                                                                              27.38                                        ATOM  3067                                                                              CZ  TYR                                                                               441                                                                               26.660                                                                             52.384                                                                             10.337                                                                             1.00                                                                              29.54                                        ATOM  3068                                                                              OH  TYR                                                                               441                                                                               25.372                                                                             52.851                                                                             10.468                                                                             1.00                                                                              30.14                                        ATOM  3069                                                                              C   TYR                                                                               441                                                                               31.047                                                                             52.990                                                                             11.815                                                                             1.00                                                                              34.37                                        ATOM  3070                                                                              O   TYR                                                                               441                                                                               30.872                                                                             52.289                                                                             12.802                                                                             1.00                                                                              33.76                                        ATOM  3071                                                                              N   ASP                                                                               442                                                                               30.749                                                                             54.286                                                                             11.791                                                                             1.00                                                                              35.80                                        ATOM  3072                                                                              CA  ASP                                                                               442                                                                               30.131                                                                             54.987                                                                             12.915                                                                             1.00                                                                              36.42                                        ATOM  3073                                                                              CB  ASP                                                                               442                                                                               31.069                                                                             56.096                                                                             13.429                                                                             1.00                                                                              42.66                                        ATOM  3074                                                                              CG  ASP                                                                               442                                                                               30.795                                                                             56.488                                                                             14.897                                                                             1.00                                                                              48.14                                        ATOM  3075                                                                              OD1 ASP                                                                               442                                                                               29.611                                                                             56.518                                                                             15.319                                                                             1.00                                                                              50.77                                        ATOM  3076                                                                              OD2 ASP                                                                               442                                                                               31.775                                                                             56.770                                                                             15.630                                                                             1.00                                                                              49.26                                        ATOM  3077                                                                              C   ASP                                                                               442                                                                               28.834                                                                             55.595                                                                             12.371                                                                             1.00                                                                              38.05                                        ATOM  3078                                                                              O   ASP                                                                               442                                                                               28.861                                                                             56.412                                                                             11.451                                                                             1.00                                                                              37.61                                        ATOM  3079                                                                              N   SER                                                                               443                                                                               27.694                                                                             55.195                                                                             12.924                                                                             1.00                                                                              39.24                                        ATOM  3080                                                                              CA  SER                                                                               443                                                                               26.406                                                                             55.697                                                                             12.456                                                                             1.00                                                                              40.93                                        ATOM  3081                                                                              CB  SER                                                                               443                                                                               25.257                                                                             54.972                                                                             13.146                                                                             1.00                                                                              43.62                                        ATOM  3082                                                                              OG  SER                                                                               443                                                                               25.233                                                                             55.289                                                                             14.529                                                                             1.00                                                                              44.57                                        ATOM  3083                                                                              C   SER                                                                               443                                                                               26.289                                                                             57.180                                                                             12.714                                                                             1.00                                                                              42.03                                        ATOM  3084                                                                              O   SER                                                                               443                                                                               25.411                                                                             57.851                                                                             12.174                                                                             1.00                                                                              39.08                                        ATOM  3085                                                                              N   LYS                                                                               444                                                                               27.130                                                                             57.661                                                                             13.620                                                                             1.00                                                                              46.56                                        ATOM  3086                                                                              CA  LYS                                                                               444                                                                               27.179                                                                             59.063                                                                             13.977                                                                             1.00                                                                              51.18                                        ATOM  3087                                                                              CB  LYS                                                                               444                                                                               27.357                                                                             59.894                                                                             12.706                                                                             1.00                                                                              53.90                                        ATOM  3088                                                                              CG  LYS                                                                               444                                                                               28.579                                                                             59.425                                                                             11.922                                                                             1.00                                                                              62.90                                        ATOM  3089                                                                              CD  LYS                                                                               444                                                                               28.719                                                                             60.075                                                                             10.563                                                                             1.00                                                                              73.49                                        ATOM  3090                                                                              CE  LYS                                                                               444                                                                               30.022                                                                             59.640                                                                             9.895                                                                              1.00                                                                              77.94                                        ATOM  3091                                                                              NZ  LYS                                                                               444                                                                               30.378                                                                             60.504                                                                             8.729                                                                              1.00                                                                              84.38                                        ATOM  3092                                                                              C   LYS                                                                               444                                                                               26.062                                                                             59.589                                                                             14.892                                                                             1.00                                                                              51.23                                        ATOM  3093                                                                              O   LYS                                                                               444                                                                               25.898                                                                             60.806                                                                             15.039                                                                             1.00                                                                              52.55                                        ATOM  3094                                                                              N   ARG                                                                               445                                                                               25.307                                                                             58.667                                                                             15.496                                                                             1.00                                                                              48.51                                        ATOM  3095                                                                              CA  ARG                                                                               445                                                                               24.265                                                                             59.004                                                                             16.468                                                                             1.00                                                                              45.71                                        ATOM  3096                                                                              CB  ARG                                                                               445                                                                               22.967                                                                             59.507                                                                             15.832                                                                             1.00                                                                              46.38                                        ATOM  3097                                                                              CG  ARG                                                                               445                                                                               22.092                                                                             60.234                                                                             16.859                                                                             1.00                                                                              44.46                                        ATOM  3098                                                                              CD  ARG                                                                               445                                                                               20.753                                                                             60.743                                                                             16.351                                                                             1.00                                                                              45.51                                        ATOM  3099                                                                              NE  ARG                                                                               445                                                                               19.999                                                                             61.330                                                                             17.464                                                                             1.00                                                                              52.32                                        ATOM  3100                                                                              CZ  ARG                                                                               445                                                                               18.887                                                                             62.053                                                                             17.347                                                                             1.00                                                                              53.85                                        ATOM  3101                                                                              NH1 ARG                                                                               445                                                                               18.294                                                                             62.533                                                                             18.437                                                                             1.00                                                                              55.79                                        ATOM  3102                                                                              NH2 ARG                                                                               445                                                                               18.351                                                                             62.286                                                                             16.155                                                                             1.00                                                                              58.42                                        ATOM  3103                                                                              C   ARG                                                                               445                                                                               23.975                                                                             57.834                                                                             17.411                                                                             1.00                                                                              44.59                                        ATOM  3104                                                                              O   ARG                                                                               445                                                                               23.439                                                                             56.801                                                                             17.012                                                                             1.00                                                                              42.64                                        ATOM  3105                                                                              N   ASN                                                                               446                                                                               24.333                                                                             58.018                                                                             18.671                                                                             1.00                                                                              47.32                                        ATOM  3106                                                                              CA  ASN                                                                               446                                                                               24.125                                                                             56.995                                                                             19.683                                                                             1.00                                                                              51.50                                        ATOM  3107                                                                              CB  ASN                                                                               446                                                                               25.218                                                                             55.918                                                                             19.582                                                                             1.00                                                                              50.30                                        ATOM  3108                                                                              CG  ASN                                                                               446                                                                               26.606                                                                             56.478                                                                             19.825                                                                             1.00                                                                              50.32                                        ATOM  3109                                                                              OD1 ASN                                                                               446                                                                               27.349                                                                             56.754                                                                             18.882                                                                             1.00                                                                              52.97                                        ATOM  3110                                                                              ND2 ASN                                                                               446                                                                               26.958                                                                             56.666                                                                             21.088                                                                             1.00                                                                              49.49                                        ATOM  3111                                                                              C   ASN                                                                               446                                                                               24.128                                                                             57.608                                                                             21.078                                                                             1.00                                                                              52.00                                        ATOM  3112                                                                              O   ASN                                                                               446                                                                               24.866                                                                             58.559                                                                             21.351                                                                             1.00                                                                              53.53                                        ATOM  3113                                                                              N   ASN                                                                               447                                                                               23.336                                                                             57.015                                                                             21.967                                                                             1.00                                                                              53.99                                        ATOM  3114                                                                              CA  ASN                                                                               447                                                                               23.195                                                                             57.460                                                                             23.358                                                                             1.00                                                                              54.97                                        ATOM  3115                                                                              CB  ASN                                                                               447                                                                               21.887                                                                             56.927                                                                             23.940                                                                             1.00                                                                              53.00                                        ATOM  3116                                                                              CG  ASN                                                                               447                                                                               20.722                                                                             57.051                                                                             22.976                                                                             1.00                                                                              54.20                                        ATOM  3117                                                                              OD1 ASN                                                                               447                                                                               20.312                                                                             58.160                                                                             22.629                                                                             1.00                                                                              59.45                                        ATOM  3118                                                                              ND2 ASN                                                                               447                                                                               20.189                                                                             55.916                                                                             22.530                                                                             1.00                                                                              53.02                                        ATOM  3119                                                                              C   ASN                                                                               447                                                                               24.345                                                                             56.951                                                                             24.222                                                                             1.00                                                                              57.40                                        ATOM  3120                                                                              O   ASN                                                                               447                                                                               24.547                                                                             57.409                                                                             25.340                                                                             1.00                                                                              62.75                                        ATOM  3121                                                                              N   GLY                                                                               448                                                                               25.075                                                                             55.981                                                                             23.689                                                                             1.00                                                                              58.44                                        ATOM  3122                                                                              CA  GLY                                                                               448                                                                               26.192                                                                             55.389                                                                             24.396                                                                             1.00                                                                              56.36                                        ATOM  3123                                                                              C   GLY                                                                               448                                                                               26.432                                                                             54.065                                                                             23.700                                                                             1.00                                                                              53.77                                        ATOM  3124                                                                              O   GLY                                                                               448                                                                               25.747                                                                             53.771                                                                             22.717                                                                             1.00                                                                              58.09                                        ATOM  3125                                                                              N   HIS                                                                               449                                                                               27.376                                                                             53.258                                                                             24.162                                                                             1.00                                                                              49.50                                        ATOM  3126                                                                              CA  HIS                                                                               449                                                                               27.599                                                                             52.007                                                                             23.458                                                                             1.00                                                                              48.10                                        ATOM  3127                                                                              CB  HIS                                                                               449                                                                               29.005                                                                             51.934                                                                             22.830                                                                             1.00                                                                              55.56                                        ATOM  3128                                                                              CG  HIS                                                                               449                                                                               29.141                                                                             52.749                                                                             21.581                                                                             1.00                                                                              61.28                                        ATOM  3129                                                                              CD2 HIS                                                                               449                                                                               29.963                                                                             53.783                                                                             21.278                                                                             1.00                                                                              61.16                                        ATOM  3130                                                                              ND1 HIS                                                                               449                                                                               28.310                                                                             52.584                                                                             20.490                                                                             1.00                                                                              63.15                                        ATOM  3131                                                                              CE1 HIS                                                                               449                                                                               28.613                                                                             53.486                                                                             19.576                                                                             1.00                                                                              65.47                                        ATOM  3132                                                                              NE2 HIS                                                                               449                                                                               29.610                                                                             54.226                                                                             20.030                                                                             1.00                                                                              65.11                                        ATOM  3133                                                                              C   HIS                                                                               449                                                                               27.338                                                                             50.745                                                                             24.196                                                                             1.00                                                                              40.97                                        ATOM  3134                                                                              O   HIS                                                                               449                                                                               28.120                                                                             50.321                                                                             25.031                                                                             1.00                                                                              42.17                                        ATOM  3135                                                                              N   VAL                                                                               450                                                                               26.212                                                                             50.143                                                                             23.908                                                                             1.00                                                                              33.34                                        ATOM  3136                                                                              CA  VAL                                                                               450                                                                               25.933                                                                             48.883                                                                             24.516                                                                             1.00                                                                              33.89                                        ATOM  3137                                                                              CB  VAL                                                                               450                                                                               24.525                                                                             48.441                                                                             24.179                                                                             1.00                                                                              27.68                                        ATOM  3138                                                                              CG1 VAL                                                                               450                                                                               24.214                                                                             47.106                                                                             24.811                                                                             1.00                                                                              23.45                                        ATOM  3139                                                                              CG2 VAL                                                                               450                                                                               23.555                                                                             49.506                                                                             24.621                                                                             1.00                                                                              19.28                                        ATOM  3140                                                                              C   VAL                                                                               450                                                                               26.961                                                                             48.066                                                                             23.742                                                                             1.00                                                                              42.79                                        ATOM  3141                                                                              O   VAL                                                                               450                                                                               27.421                                                                             48.496                                                                             22.674                                                                             1.00                                                                              48.77                                        ATOM  3142                                                                              N   SER                                                                               451                                                                               27.392                                                                             46.937                                                                             24.273                                                                             1.00                                                                              47.08                                        ATOM  3143                                                                              CA  SER                                                                               451                                                                               28.383                                                                             46.149                                                                             23.550                                                                             1.00                                                                              46.69                                        ATOM  3144                                                                              CB  SER                                                                               451                                                                               29.418                                                                             45.553                                                                             24.529                                                                             1.00                                                                              49.40                                        ATOM  3145                                                                              OG  SER                                                                               451                                                                               30.187                                                                             46.575                                                                             25.155                                                                             1.00                                                                              52.97                                        ATOM  3146                                                                              C   SER                                                                               451                                                                               27.758                                                                             45.054                                                                             22.677                                                                             1.00                                                                              44.69                                        ATOM  3147                                                                              O   SER                                                                               451                                                                               26.524                                                                             44.869                                                                             22.643                                                                             1.00                                                                              43.38                                        ATOM  3148                                                                              N   ALA                                                                               452                                                                               28.612                                                                             44.394                                                                             23.904                                                                             1.00                                                                              40.41                                        ATOM  3149                                                                              CA  ALA                                                                               452                                                                               28.181                                                                             43.315                                                                             21.037                                                                             1.00                                                                              37.56                                        ATOM  3150                                                                              CB  ALA                                                                               452                                                                               27.379                                                                             43.865                                                                             19.841                                                                             1.00                                                                              35.98                                        ATOM  3151                                                                              C   ALA                                                                               452                                                                               29.378                                                                             42.474                                                                             20.577                                                                             1.00                                                                              35.17                                        ATOM  3152                                                                              O   ALA                                                                               452                                                                               30.446                                                                             42.482                                                                             21.188                                                                             1.00                                                                              34.47                                        ATOM  3153                                                                              N   GLN                                                                               453                                                                               29.215                                                                             41.832                                                                             19.438                                                                             1.00                                                                              31.36                                        ATOM  3154                                                                              CA  GLN                                                                               453                                                                               30.208                                                                             40.947                                                                             18.882                                                                             1.00                                                                              28.35                                        ATOM  3155                                                                              CB  GLN                                                                               453                                                                               29.638                                                                             40.360                                                                             17.578                                                                             1.00                                                                              31.30                                        ATOM  3156                                                                              CG  GLN                                                                               453                                                                               30.246                                                                             39.018                                                                             17.163                                                                             1.00                                                                              32.89                                        ATOM  3157                                                                              CD  GLN                                                                               453                                                                               29.737                                                                             38.530                                                                             15.832                                                                             1.00                                                                              31.23                                        ATOM  3158                                                                              OE1 GLN                                                                               453                                                                               30.143                                                                             39.026                                                                             14.779                                                                             1.00                                                                              34.14                                        ATOM  3159                                                                              NE2 GLN                                                                               453                                                                               28.845                                                                             37.556                                                                             15.868                                                                             1.00                                                                              28.65                                        ATOM  3160                                                                              C   GLN                                                                               453                                                                               31.681                                                                             41.343                                                                             18.676                                                                             1.00                                                                              25.25                                        ATOM  3161                                                                              O   GLN                                                                               453                                                                               32.005                                                                             42.349                                                                             18.039                                                                             1.00                                                                              25.08                                        ATOM  3162                                                                              N   ASP                                                                               454                                                                               32.565                                                                             40.513                                                                             19.222                                                                             1.00                                                                              24.22                                        ATOM  3163                                                                              CA  ASP                                                                               454                                                                               33.998                                                                             40.645                                                                             19.019                                                                             1.00                                                                              23.88                                        ATOM  3164                                                                              CB  ASP                                                                               454                                                                               34.776                                                                             40.663                                                                             20.321                                                                             1.00                                                                              23.71                                        ATOM  3165                                                                              CG  ASP                                                                               454                                                                               36.292                                                                             40.678                                                                             20.099                                                                             1.00                                                                              27.65                                        ATOM  3166                                                                              OD1 ASP                                                                               454                                                                               36.752                                                                             40.687                                                                             18.941                                                                             1.00                                                                              26.59                                        ATOM  3167                                                                              OD2 ASP                                                                               454                                                                               37.040                                                                             40.670                                                                             21.098                                                                             1.00                                                                              34.10                                        ATOM  3168                                                                              C   ASP                                                                               454                                                                               34.274                                                                             39.332                                                                             18.299                                                                             1.00                                                                              28.07                                        ATOM  3169                                                                              O   ASP                                                                               454                                                                               33.990                                                                             38.257                                                                             18.841                                                                             1.00                                                                              26.35                                        ATOM  3170                                                                              N   SER                                                                               455                                                                               34.800                                                                             39.409                                                                             17.077                                                                             1.00                                                                              30.04                                        ATOM  3171                                                                              CA  SER                                                                               455                                                                               35.073                                                                             38.204                                                                             16.273                                                                             1.00                                                                              27.99                                        ATOM  3172                                                                              CB  SER                                                                               455                                                                               35.589                                                                             38.575                                                                             14.877                                                                             1.00                                                                              23.39                                        ATOM  3173                                                                              OG  SER                                                                               455                                                                               36.916                                                                             39.063                                                                             14.946                                                                             1.00                                                                              32.54                                        ATOM  3174                                                                              C   SER                                                                               455                                                                               35.966                                                                             37.112                                                                             16.882                                                                             1.00                                                                              26.74                                        ATOM  3175                                                                              O   SER                                                                               455                                                                               35.650                                                                             35.928                                                                             16.736                                                                             1.00                                                                              28.30                                        ATOM  3176                                                                              N   ILE                                                                               456                                                                               37.057                                                                             37.482                                                                             17.563                                                                             1.00                                                                              23.67                                        ATOM  3177                                                                              CA  ILE                                                                               456                                                                               37.948                                                                             36.485                                                                             18.155                                                                             1.00                                                                              18.04                                        ATOM  3178                                                                              CB  ILE                                                                               456                                                                               39.083                                                                             37.138                                                                             18.933                                                                             1.00                                                                              23.55                                        ATOM  3179                                                                              CG2 ILE                                                                               456                                                                               39.990                                                                             37.911                                                                             17.978                                                                             1.00                                                                              17.58                                        ATOM  3180                                                                              CG1 ILE                                                                               456                                                                               38.498                                                                             38.012                                                                             20.047                                                                             1.00                                                                              30.14                                        ATOM  3181                                                                              CD1 ILE                                                                               456                                                                               39.487                                                                             38.426                                                                             21.128                                                                             1.00                                                                              35.57                                        ATOM  3182                                                                              C   ILE                                                                               456                                                                               37.246                                                                             35.486                                                                             19.077                                                                             1.00                                                                              20.83                                        ATOM  3183                                                                              O   ILE                                                                               456                                                                               37.703                                                                             34.354                                                                             19.260                                                                             1.00                                                                              16.93                                        ATOM  3184                                                                              N   ASP                                                                               457                                                                               36.138                                                                             35.896                                                                             19.673                                                                             1.00                                                                              22.41                                        ATOM  3185                                                                              CA  ASP                                                                               457                                                                               35.416                                                                             34.996                                                                             20.550                                                                             1.00                                                                              27.43                                        ATOM  3186                                                                              CB  ASP                                                                               457                                                                               34.324                                                                             35.751                                                                             21.328                                                                             1.00                                                                              34.30                                        ATOM  3187                                                                              CG  ASP                                                                               457                                                                               34.900                                                                             36.788                                                                             22.308                                                                             1.00                                                                              41.24                                        ATOM  3188                                                                              OD1 ASP                                                                               457                                                                               34.382                                                                             37.925                                                                             22.363                                                                             1.00                                                                              44.36                                        ATOM  3189                                                                              OD2 ASP                                                                               457                                                                               35.874                                                                             36.471                                                                             23.032                                                                             1.00                                                                              50.52                                        ATOM  3190                                                                              C   ASP                                                                               457                                                                               34.847                                                                             33.825                                                                             19.742                                                                             1.00                                                                              27.01                                        ATOM  3191                                                                              O   ASP                                                                               457                                                                               34.839                                                                             32.685                                                                             20.210                                                                             1.00                                                                              31.27                                        ATOM  3192                                                                              N   GLN                                                                               458                                                                               34.413                                                                             34.096                                                                             18.515                                                                             1.00                                                                              27.92                                        ATOM  3193                                                                              CA  GLN                                                                               458                                                                               33.883                                                                             33.044                                                                             17.632                                                                             1.00                                                                              30.33                                        ATOM  3194                                                                              CB  GLN                                                                               458                                                                               32.932                                                                             33.614                                                                             16.573                                                                             1.00                                                                              29.37                                        ATOM  3195                                                                              CG  GLN                                                                               458                                                                               31.866                                                                             34.561                                                                             17.053                                                                             1.00                                                                              32.48                                        ATOM  3196                                                                              CD  GLN                                                                               458                                                                               30.514                                                                             33.939                                                                             16.989                                                                             1.00                                                                              33.02                                        ATOM  3197                                                                              OE1 GLN                                                                               458                                                                               29.750                                                                             33.981                                                                             17.947                                                                             1.00                                                                              41.92                                        ATOM  3198                                                                              NE2 GLN                                                                               458                                                                               30.212                                                                             33.316                                                                             15.872                                                                             1.00                                                                              37.05                                        ATOM  3199                                                                              C   GLN                                                                               458                                                                               35.037                                                                             32.357                                                                             16.869                                                                             1.00                                                                              28.95                                        ATOM  3200                                                                              O   GLN                                                                               458                                                                               35.049                                                                             31.133                                                                             16.719                                                                             1.00                                                                              26.34                                        ATOM  3201                                                                              N   LEU                                                                               459                                                                               35.982                                                                             33.158                                                                             16.368                                                                             1.00                                                                              24.82                                        ATOM  3202                                                                              CA  LEU                                                                               459                                                                               37.107                                                                             32.652                                                                             15.587                                                                             1.00                                                                              19.59                                        ATOM  3203                                                                              CB  LEU                                                                               459                                                                               37.033                                                                             33.236                                                                             14.183                                                                             1.00                                                                              17.07                                        ATOM  3204                                                                              CG  LEU                                                                               459                                                                               35.684                                                                             32.976                                                                             13.504                                                                             1.00                                                                              19.32                                        ATOM  3205                                                                              CD1 LEU                                                                               459                                                                               35.541                                                                             33.890                                                                             12.331                                                                             1.00                                                                              16.44                                        ATOM  3206                                                                              CD2 LEU                                                                               459                                                                               35.549                                                                             31.523                                                                             13.074                                                                             1.00                                                                              11.36                                        ATOM  3207                                                                              C   LEU                                                                               459                                                                               38.455                                                                             32.987                                                                             16.182                                                                             1.00                                                                              15.91                                        ATOM  3208                                                                              O   LEU                                                                               459                                                                               39.175                                                                             33.815                                                                             15.651                                                                             1.00                                                                              14.53                                        ATOM  3209                                                                              N   PRO                                                                               460                                                                               38.820                                                                             32.339                                                                             17.299                                                                             1.00                                                                              16.20                                        ATOM  3210                                                                              CD  PRO                                                                               460                                                                               38.042                                                                             31.315                                                                             18.012                                                                             1.00                                                                              17.21                                        ATOM  3211                                                                              CA  PRO                                                                               460                                                                               40.106                                                                             32.589                                                                             17.960                                                                             1.00                                                                              15.73                                        ATOM  3212                                                                              CB  PRO                                                                               460                                                                               40.133                                                                             31.541                                                                             19.086                                                                             1.00                                                                              17.01                                        ATOM  3213                                                                              CG  PRO                                                                               460                                                                               39.123                                                                             30.494                                                                             18.642                                                                             1.00                                                                              17.80                                        ATOM  3214                                                                              C   PRO                                                                               460                                                                               41.257                                                                             32.386                                                                             17.008                                                                             1.00                                                                              16.53                                        ATOM  3215                                                                              O   PRO                                                                               460                                                                               41.079                                                                             31.758                                                                             15.967                                                                             1.00                                                                              22.97                                        ATOM  3216                                                                              N   PRO                                                                               461                                                                               42.426                                                                             32.982                                                                             17.302                                                                             1.00                                                                              16.43                                        ATOM  3217                                                                              CD  PRO                                                                               461                                                                               42.687                                                                             33.873                                                                             18.451                                                                             1.00                                                                              16.11                                        ATOM  3218                                                                              CA  PRO                                                                               461                                                                               43.615                                                                             32.858                                                                             16.455                                                                             1.00                                                                              19.04                                        ATOM  3219                                                                              CB  PRO                                                                               461                                                                               44.550                                                                             33.938                                                                             17.011                                                                             1.00                                                                              17.90                                        ATOM  3220                                                                              CG  PRO                                                                               461                                                                               44.190                                                                             33.962                                                                             18.467                                                                             1.00                                                                              17.10                                        ATOM  3221                                                                              C   PRO                                                                               461                                                                               44.217                                                                             31.470                                                                             16.624                                                                             1.00                                                                              22.01                                        ATOM  3222                                                                              O   PRO                                                                               461                                                                               43.757                                                                             30.678                                                                             17.448                                                                             1.00                                                                              25.54                                        ATOM  3223                                                                              N   GLU                                                                               462                                                                               45.247                                                                             31.169                                                                             15.856                                                                             1.00                                                                              25.14                                        ATOM  3224                                                                              CA  GLU                                                                               462                                                                               45.888                                                                             29.877                                                                             15.958                                                                             1.00                                                                              28.39                                        ATOM  3225                                                                              CB  GLU                                                                               462                                                                               46.625                                                                             29.560                                                                             14.674                                                                             1.00                                                                              22.97                                        ATOM  3226                                                                              CG  GLU                                                                               462                                                                               45.675                                                                             29.090                                                                             13.627                                                                             1.00                                                                              21.83                                        ATOM  3227                                                                              CD  GLU                                                                               462                                                                               46.320                                                                             28.834                                                                             12.299                                                                             1.00                                                                              25.80                                        ATOM  3228                                                                              OE1 GLU                                                                               462                                                                               47.571                                                                             28.780                                                                             12.227                                                                             1.00                                                                              29.20                                        ATOM  3229                                                                              OE2 GLU                                                                               462                                                                               45.562                                                                             28.693                                                                             11.318                                                                             1.00                                                                              20.77                                        ATOM  3230                                                                              C   GLU                                                                               462                                                                               46.780                                                                             29.678                                                                             17.181                                                                             1.00                                                                              33.43                                        ATOM  3231                                                                              O   GLU                                                                               462                                                                               46.989                                                                             28.533                                                                             17.586                                                                             1.00                                                                              35.01                                        ATOM  3232                                                                              N   THR                                                                               463                                                                               47.307                                                                             30.775                                                                             17.745                                                                             1.00                                                                              37.95                                        ATOM  3233                                                                              CA  THR                                                                               463                                                                               48.170                                                                             30.767                                                                             18.946                                                                             1.00                                                                              40.65                                        ATOM  3234                                                                              CB  THR                                                                               463                                                                               49.674                                                                             30.861                                                                             18.635                                                                             1.00                                                                              40.48                                        ATOM  3235                                                                              OG1 THR                                                                               463                                                                               49.945                                                                             30.372                                                                             17.321                                                                             1.00                                                                              44.41                                        ATOM  3236                                                                              CG2 THR                                                                               463                                                                               50.464                                                                             30.089                                                                             19.671                                                                             1.00                                                                              40.34                                        ATOM  3237                                                                              C   THR                                                                               463                                                                               47.920                                                                             32.088                                                                             19.616                                                                             1.00                                                                              42.47                                        ATOM  3238                                                                              O   THR                                                                               463                                                                               47.497                                                                             33.022                                                                             18.952                                                                             1.00                                                                              41.83                                        ATOM  3239                                                                              N   THR                                                                               464                                                                               48.331                                                                             32.210                                                                             20.874                                                                             1.00                                                                              48.42                                        ATOM  3240                                                                              CA  THR                                                                               464                                                                               48.155                                                                             33.457                                                                             21.622                                                                             1.00                                                                              55.33                                        ATOM  3241                                                                              CB  THR                                                                               464                                                                               47.453                                                                             33.204                                                                             22.959                                                                             1.00                                                                              57.02                                        ATOM  3242                                                                              OG1 THR                                                                               464                                                                               48.099                                                                             32.118                                                                             23.633                                                                             1.00                                                                              62.71                                        ATOM  3243                                                                              CG2 THR                                                                               464                                                                               45.984                                                                             32.855                                                                             22.730                                                                             1.00                                                                              59.94                                        ATOM  3244                                                                              C   THR                                                                               464                                                                               49.474                                                                             34.195                                                                             21.879                                                                             1.00                                                                              58.07                                        ATOM  3245                                                                              O   THR                                                                               464                                                                               49.500                                                                             35.416                                                                             22.085                                                                             1.00                                                                              58.66                                        ATOM  3246                                                                              N   ASP                                                                               465                                                                               50.573                                                                             33.453                                                                             21.878                                                                             1.00                                                                              61.40                                        ATOM  3247                                                                              CA  ASP                                                                               465                                                                               51.881                                                                             34.065                                                                             22.091                                                                             1.00                                                                              65.65                                        ATOM  3248                                                                              CB  ASP                                                                               465                                                                               52.843                                                                             33.061                                                                             22.731                                                                             1.00                                                                              66.43                                        ATOM  3249                                                                              CG  ASP                                                                               465                                                                               52.793                                                                             31.700                                                                             22.069                                                                             1.00                                                                              64.17                                        ATOM  3250                                                                              OD1 ASP                                                                               465                                                                               52.245                                                                             30.777                                                                             22.709                                                                             1.00                                                                              61.40                                        ATOM  3251                                                                              OD2 ASP                                                                               465                                                                               53.302                                                                             31.556                                                                             20.929                                                                             1.00                                                                              62.59                                        ATOM  3252                                                                              C   ASP                                                                               465                                                                               52.431                                                                             34.573                                                                             20.757                                                                             1.00                                                                              66.66                                        ATOM  3253                                                                              O   ASP                                                                               465                                                                               53.641                                                                             34.569                                                                             20.518                                                                             1.00                                                                              70.16                                        ATOM  3254                                                                              N   GLU                                                                               466                                                                               51.520                                                                             35.002                                                                             19.893                                                                             1.00                                                                              64.93                                        ATOM  3255                                                                              CA  GLU                                                                               466                                                                               51.851                                                                             35.511                                                                             18.577                                                                             1.00                                                                              60.06                                        ATOM  3256                                                                              CB  GLU                                                                               466                                                                               51.574                                                                             34.444                                                                             17.528                                                                             1.00                                                                              64.82                                        ATOM  3257                                                                              CG  GLU                                                                               466                                                                               52.657                                                                             33.415                                                                             17.372                                                                             1.00                                                                              71.79                                        ATOM  3258                                                                              CD  GLU                                                                               466                                                                               53.441                                                                             33.627                                                                             16.098                                                                             1.00                                                                              76.80                                        ATOM  3259                                                                              OE1 GLU                                                                               466                                                                               52.797                                                                             33.726                                                                             15.024                                                                             1.00                                                                              78.10                                        ATOM  3260                                                                              OE2 GLU                                                                               466                                                                               54.691                                                                             33.703                                                                             16.173                                                                             1.00                                                                              79.01                                        ATOM  3261                                                                              C   GLU                                                                               466                                                                               50.918                                                                             36.674                                                                             18.332                                                                             1.00                                                                              56.09                                        ATOM  3262                                                                              O   GLU                                                                               466                                                                               49.742                                                                             36.607                                                                             18.684                                                                             1.00                                                                              56.03                                        ATOM  3263                                                                              N   PRO                                                                               467                                                                               51.447                                                                             37.799                                                                             17.831                                                                             1.00                                                                              51.07                                        ATOM  3264                                                                              CD  PRO                                                                               467                                                                               52.847                                                                             38.171                                                                             17.597                                                                             1.00                                                                              49.21                                        ATOM  3265                                                                              CA  PRO                                                                               467                                                                               50.566                                                                             38.933                                                                             17.572                                                                             1.00                                                                              46.48                                        ATOM  3266                                                                              CB  PRO                                                                               467                                                                               51.486                                                                             39.931                                                                             16.858                                                                             1.00                                                                              48.89                                        ATOM  3267                                                                              CG  PRO                                                                               467                                                                               52.701                                                                             39.128                                                                             16.465                                                                             1.00                                                                              47.91                                        ATOM  3268                                                                              C   PRO                                                                               467                                                                               49.408                                                                             38.481                                                                             16.695                                                                             1.00                                                                              44.45                                        ATOM  3269                                                                              O   PRO                                                                               467                                                                               49.600                                                                             37.737                                                                             15.721                                                                             1.00                                                                              42.21                                        ATOM  3270                                                                              N   LEU                                                                               468                                                                               48.212                                                                             38.924                                                                             17.059                                                                             1.00                                                                              40.59                                        ATOM  3271                                                                              CA  LEU                                                                               468                                                                               46.995                                                                             38.561                                                                             16.352                                                                             1.00                                                                              40.01                                        ATOM  3272                                                                              CB  LEU                                                                               468                                                                               45.839                                                                             39.431                                                                             16.837                                                                             1.00                                                                              41.89                                        ATOM  3273                                                                              CG  LEU                                                                               468                                                                               44.463                                                                             39.052                                                                             16.305                                                                             1.00                                                                              41.02                                        ATOM  3274                                                                              CD1 LEU                                                                               468                                                                               44.105                                                                             37.664                                                                             16.775                                                                             1.00                                                                              42.02                                        ATOM  3275                                                                              CD2 LEU                                                                               468                                                                               43.447                                                                             40.052                                                                             16.786                                                                             1.00                                                                              44.91                                        ATOM  3276                                                                              C   LEU                                                                               468                                                                               47.086                                                                             38.602                                                                             14.824                                                                             1.00                                                                              37.52                                        ATOM  3277                                                                              O   LEU                                                                               468                                                                               46.714                                                                             37.647                                                                             14.153                                                                             1.00                                                                              36.89                                        ATOM  3278                                                                              N   GLU                                                                               469                                                                               47.622                                                                             39.690                                                                             14.286                                                                             1.00                                                                              38.63                                        ATOM  3279                                                                              CA  GLU                                                                               469                                                                               47.761                                                                             39.881                                                                             12.831                                                                             1.00                                                                              36.54                                        ATOM  3280                                                                              CB  GLU                                                                               469                                                                               48.312                                                                             41.280                                                                             12.543                                                                             1.00                                                                              36.96                                        ATOM  3281                                                                              CG  GLU                                                                               469                                                                               49.822                                                                             41.402                                                                             12.774                                                                             1.00                                                                              36.18                                        ATOM  3282                                                                              CD  GLU                                                                               469                                                                               50.168                                                                             42.065                                                                             14.072                                                                             1.00                                                                              33.77                                        ATOM  3283                                                                              OE1 GLU                                                                               469                                                                               51.233                                                                             42.715                                                                             14.107                                                                             1.00                                                                              36.01                                        ATOM  3284                                                                              OE2 GLU                                                                               469                                                                               49.382                                                                             41.945                                                                             15.043                                                                             1.00                                                                              30.63                                        AT6M  3285                                                                              C   GLU                                                                               469                                                                               48.682                                                                             38.859                                                                             12.174                                                                             1.00                                                                              35.12                                        ATOM  3286                                                                              O   GLU                                                                               469                                                                               48.816                                                                             38.801                                                                             10.941                                                                             1.00                                                                              32.72                                        ATOM  3287                                                                              N   LYS                                                                               470                                                                               49.357                                                                             38.106                                                                             13.033                                                                             1.00                                                                              37.81                                        ATOM  3288                                                                              CA  LYS                                                                               470                                                                               50.305                                                                             37.094                                                                             12.640                                                                             1.00                                                                              36.11                                        ATOM  3289                                                                              CB  LYS                                                                               470                                                                               51.646                                                                             37.391                                                                             13.271                                                                             1.00                                                                              40.29                                        ATOM  3290                                                                              CG  LYS                                                                               470                                                                               52.622                                                                             37.924                                                                             12.260                                                                             1.00                                                                              50.88                                        ATOM  3291                                                                              CD  LYS                                                                               470                                                                               53.757                                                                             36.936                                                                             12.100                                                                             1.00                                                                              59.58                                        ATOM  3292                                                                              CE  LYS                                                                               470                                                                               53.236                                                                             35.529                                                                             11.834                                                                             1.00                                                                              61.72                                        ATOM  3293                                                                              NZ  LYS                                                                               470                                                                               53.976                                                                             34.506                                                                             12.630                                                                             1.00                                                                              64.89                                        ATOM  3294                                                                              C   LYS                                                                               470                                                                               49.865                                                                             35.711                                                                             13.034                                                                             1.00                                                                              36.21                                        ATOM  3295                                                                              O   LYS                                                                               470                                                                               50.504                                                                             34.733                                                                             12.659                                                                             1.00                                                                              39.63                                        ATOM  3296                                                                              N   ALA                                                                               471                                                                               48.771                                                                             35.613                                                                             13.779                                                                             1.00                                                                              33.18                                        ATOM  3297                                                                              CA  ALA                                                                               471                                                                               48.284                                                                             34.310                                                                             14.182                                                                             1.00                                                                              29.06                                        ATOM  3298                                                                              CB  ALA                                                                               471                                                                               48.598                                                                             34.060                                                                             15.651                                                                             1.00                                                                              25.21                                        ATOM  3299                                                                              C   ALA                                                                               471                                                                               46.799                                                                             34.083                                                                             13.911                                                                             1.00                                                                              29.06                                        ATOM  3300                                                                              O   ALA                                                                               471                                                                               46.295                                                                             33.013                                                                             14.238                                                                             1.00                                                                              31.11                                        ATOM  3301                                                                              N   TYR                                                                               472                                                                               46.091                                                                             35.046                                                                             13.311                                                                             1.00                                                                              26.54                                        ATOM  3302                                                                              CA  TYR                                                                               472                                                                               44.650                                                                             34.861                                                                             13.057                                                                             1.00                                                                              23.18                                        ATOM  3303                                                                              CB  TYR                                                                               472                                                                               43.999                                                                             36.124                                                                             12.507                                                                             1.00                                                                              18.72                                        ATOM  3304                                                                              CG  TYR                                                                               472                                                                               44.489                                                                             36.511                                                                             11.157                                                                             1.00                                                                              22.75                                        ATOM  3305                                                                              CD1 TYR                                                                               472                                                                               43.860                                                                             36.031                                                                             10.020                                                                             1.00                                                                              25.95                                        ATOM  3306                                                                              CE1 TYR                                                                               472                                                                               44.294                                                                             36.381                                                                             8.756                                                                              1.00                                                                              27.97                                        ATOM  3307                                                                              CD2 TYR                                                                               472                                                                               45.575                                                                             37.365                                                                             11.003                                                                             1.00                                                                              22.21                                        ATOM  3308                                                                              CE2 TYR                                                                               472                                                                               46.022                                                                             37.738                                                                             9.739                                                                              1.00                                                                              26.59                                        ATOM  3309                                                                              CZ  TYR                                                                               472                                                                               45.372                                                                             37.233                                                                             8.609                                                                              1.00                                                                              32.17                                        ATOM  3310                                                                              OH  TYR                                                                               472                                                                               45.797                                                                             37.549                                                                             7.327                                                                              1.00                                                                              36.52                                        ATOM  3311                                                                              C   TYR                                                                               472                                                                               44.325                                                                             33.647                                                                             12.183                                                                             1.00                                                                              20.40                                        ATOM  3312                                                                              O   TYR                                                                               472                                                                               45.114                                                                             33.226                                                                             11.354                                                                             1.00                                                                              22.10                                        ATOM  3313                                                                              N   SER                                                                               473                                                                               43.161                                                                             33.073                                                                             12.393                                                                             1.00                                                                              15.42                                        ATOM  3314                                                                              CA  SER                                                                               473                                                                               42.773                                                                             31.901                                                                             11.654                                                                             1.00                                                                              18.76                                        ATOM  3315                                                                              CB  SER                                                                               473                                                                               42.068                                                                             30.968                                                                             12.596                                                                             1.00                                                                              20.56                                        ATOM  3316                                                                              OG  SER                                                                               473                                                                               40.944                                                                             31.663                                                                             13.113                                                                             1.00                                                                              18.80                                        ATOM  3317                                                                              C   SER                                                                               473                                                                               41.843                                                                             32.190                                                                             10.482                                                                             1.00                                                                              21.56                                        ATOM  3318                                                                              O   SER                                                                               473                                                                               41.654                                                                             31.317                                                                             9.623                                                                              1.00                                                                              22.66                                        ATOM  3319                                                                              N   HIS                                                                               474                                                                               41.203                                                                             33.366                                                                             10.478                                                                             1.00                                                                              21.81                                        ATOM  3320                                                                              CA  HIS                                                                               474                                                                               40.269                                                                             33.739                                                                             9.405                                                                              1.00                                                                              19.11                                        ATOM  3321                                                                              CB  HIS                                                                               474                                                                               38.841                                                                             33.314                                                                             9.752                                                                              1.00                                                                              15.89                                        ATOM  3322                                                                              CG  HIS                                                                               474                                                                               38.702                                                                             31.860                                                                             10.093                                                                             1.00                                                                              12.80                                        ATOM  3323                                                                              CD2 HIS                                                                               474                                                                               39.069                                                                             31.170                                                                             11.192                                                                             1.00                                                                              8.32                                         ATOM  3324                                                                              ND1 HIS                                                                               474                                                                               38.030                                                                             30.966                                                                             9.289                                                                              1.00                                                                              17.15                                        ATOM  3325                                                                              CE1 HIS                                                                               474                                                                               37.981                                                                             29.793                                                                             9.880                                                                              1.00                                                                              13.99                                        ATOM  3326                                                                              NE2 HIS                                                                               474                                                                               38.605                                                                             29.889                                                                             11.040                                                                             1.00                                                                              16.43                                        ATOM  3327                                                                              C   HIS                                                                               474                                                                               40.234                                                                             35.218                                                                             9.045                                                                              1.00                                                                              20.13                                        ATOM  3328                                                                              O   HIS                                                                               474                                                                               40.591                                                                             36.079                                                                             9.837                                                                              1.00                                                                              22.30                                        ATOM  3329                                                                              N   GLN                                                                               475                                                                               39.750                                                                             35.493                                                                             7.844                                                                              1.00                                                                              22.49                                        ATOM  3330                                                                              CA  GLN                                                                               475                                                                               39.613                                                                             36.848                                                                             7.328                                                                              1.00                                                                              23.06                                        ATOM  3331                                                                              CB  GLN                                                                               475                                                                               40.571                                                                             37.061                                                                             6.155                                                                              1.00                                                                              27.55                                        ATOM  3332                                                                              CG  GLN                                                                               475                                                                               40.762                                                                             35.814                                                                             5.317                                                                              1.00                                                                              44.65                                        ATOM  3333                                                                              CD  GLN                                                                               475                                                                               41.572                                                                             36.048                                                                             4.068                                                                              1.00                                                                              53.46                                        ATOM  3334                                                                              OE1 GLN                                                                               475                                                                               42.346                                                                             35.175                                                                             3.640                                                                              1.00                                                                              61.88                                        ATOM  3335                                                                              NE2 GLN                                                                               475                                                                               41.399                                                                             37.226                                                                             3.458                                                                              1.00                                                                              53.85                                        ATOM  3336                                                                              C   GLN                                                                               475                                                                               38.161                                                                             37.067                                                                             6.880                                                                              1.00                                                                              20.99                                        ATOM  3337                                                                              O   GLN                                                                               475                                                                               37.449                                                                             36.108                                                                             6.561                                                                              1.00                                                                              19.73                                        ATOM  3338                                                                              N   LEU                                                                               476                                                                               37.700                                                                             38.314                                                                             6.965                                                                              1.00                                                                              23.59                                        ATOM  3339                                                                              CA  LEU                                                                               476                                                                               36.337                                                                             38.691                                                                             6.566                                                                              1.00                                                                              23.47                                        ATOM  3340                                                                              CB  LEU                                                                               476                                                                               36.004                                                                             40.117                                                                             7.035                                                                              1.00                                                                              18.61                                        ATOM  3341                                                                              CG  LEU                                                                               476                                                                               34.553                                                                             40.579                                                                             6.997                                                                              1.00                                                                              13.45                                        ATOM  3342                                                                              CD1 LEU                                                                               476                                                                               33.742                                                                             39.763                                                                             7.990                                                                              1.00                                                                              17.94                                        ATOM  3343                                                                              CD2 LEU                                                                               476                                                                               34.476                                                                             42.042                                                                             7.354                                                                              1.00                                                                              16.38                                        ATOM  3344                                                                              C   LEU                                                                               476                                                                               36.224                                                                             38.573                                                                             5.037                                                                              1.00                                                                              25.91                                        ATOM  3345                                                                              O   LEU                                                                               476                                                                               37.137                                                                             38.974                                                                             4.278                                                                              1.00                                                                              24.64                                        ATOM  3346                                                                              N   ASN                                                                               477                                                                               35.111                                                                             37.999                                                                             4.601                                                                              1.00                                                                              23.61                                        ATOM  3347                                                                              CA  ASN                                                                               477                                                                               34.851                                                                             37.764                                                                             3.200                                                                              1.00                                                                              25.65                                        ATOM  3348                                                                              CB  ASN                                                                               477                                                                               34.815                                                                             36.245                                                                             2.978                                                                              1.00                                                                              26.73                                        ATOM  3349                                                                              CG  ASN                                                                               477                                                                               34.376                                                                             35.858                                                                             1.594                                                                              1.00                                                                              30.01                                        ATOM  3350                                                                              OD1 ASN                                                                               477                                                                               33.219                                                                             35.499                                                                             1.369                                                                              1.00                                                                              34.38                                        ATOM  3351                                                                              ND2 ASN                                                                               477                                                                               35.299                                                                             35.899                                                                             0.659                                                                              1.00                                                                              27.30                                        ATOM  3352                                                                              C   ASN                                                                               477                                                                               33.560                                                                             38.435                                                                             2.701                                                                              1.00                                                                              27.24                                        ATOM  3353                                                                              O   ASN                                                                               477                                                                               33.509                                                                             38.929                                                                             1.575                                                                              1.00                                                                              30.67                                        ATOM  3354                                                                              N   TYR                                                                               478                                                                               32.583                                                                             38.597                                                                             3.587                                                                              1.00                                                                              28.03                                        ATOM  3355                                                                              CA  TYR                                                                               478                                                                               31.283                                                                             39.159                                                                             3.214                                                                              1.00                                                                              26.02                                        ATOM  3356                                                                              CB  TYR                                                                               478                                                                               30.437                                                                             38.021                                                                             2.617                                                                              1.00                                                                              28.82                                        ATOM  3357                                                                              CG  TYR                                                                               478                                                                               29.454                                                                             38.399                                                                             1.528                                                                              1.00                                                                              29.16                                        ATOM  3358                                                                              CD1 TYR                                                                               478                                                                               29.910                                                                             38.749                                                                             0.244                                                                              1.00                                                                              29.31                                        ATOM  3359                                                                              CE1 TYR                                                                               478                                                                               29.019                                                                             39.022                                                                             -0.799                                                                             1.00                                                                              29.21                                        ATOM  3360                                                                              CD2 TYR                                                                               478                                                                               28.072                                                                             38.337                                                                             1.746                                                                              1.00                                                                              25.53                                        ATOM  3361                                                                              CE2 TYR                                                                               478                                                                               27.170                                                                             38.609                                                                             0.702                                                                              1.00                                                                              31.35                                        ATOM  3362                                                                              CZ  TYR                                                                               478                                                                               27.663                                                                             38.949                                                                             -0.565                                                                             1.00                                                                              28.53                                        ATOM  3363                                                                              OH  TYR                                                                               478                                                                               26.818                                                                             39.188                                                                             -1.609                                                                             1.00                                                                              29.12                                        ATOM  3364                                                                              C   TYR                                                                               478                                                                               30.536                                                                             39.751                                                                             4.435                                                                              1.00                                                                              27.26                                        ATOM  3365                                                                              O   TYR                                                                               478                                                                               30.816                                                                             39.412                                                                             5.582                                                                              1.00                                                                              26.91                                        ATOM  3366                                                                              N   ALA                                                                               479                                                                               29.592                                                                             40.642                                                                             4.163                                                                              1.00                                                                              26.82                                        ATOM  3367                                                                              CA  ALA                                                                               479                                                                               28.761                                                                             41.273                                                                             5.178                                                                              1.00                                                                              26.75                                        ATOM  3368                                                                              CB  ALA                                                                               479                                                                               29.283                                                                             42.665                                                                             5.500                                                                              1.00                                                                              26.06                                        ATOM  3369                                                                              C   ALA                                                                               479                                                                               27.377                                                                             41.336                                                                             4.519                                                                              1.00                                                                              25.07                                        ATOM  3370                                                                              O   ALA                                                                               479                                                                               27.265                                                                             41.549                                                                             3.309                                                                              1.00                                                                              28.22                                        ATOM  3371                                                                              N   GLU                                                                               480                                                                               26.329                                                                             41.078                                                                             5.275                                                                              1.00                                                                              24.88                                        ATOM  3372                                                                              CA  GLU                                                                               480                                                                               25.008                                                                             41.108                                                                             4.677                                                                              1.00                                                                              30.15                                        ATOM  3373                                                                              CB  GLU                                                                               480                                                                               24.750                                                                             39.764                                                                             4.005                                                                              1.00                                                                              30.81                                        ATOM  3374                                                                              CG  GLU                                                                               480                                                                               23.335                                                                             39.525                                                                             3.511                                                                              1.00                                                                              34.30                                        ATOM  3375                                                                              CD  GLU                                                                               480                                                                               23.158                                                                             38.143                                                                             2.856                                                                              1.00                                                                              37.80                                        ATOM  3376                                                                              OE1 GLU                                                                               480                                                                               22.025                                                                             37.848                                                                             2.398                                                                              1.00                                                                              38.54                                        ATOM  3377                                                                              OE2 GLU                                                                               480                                                                               24.138                                                                             37.352                                                                             2.802                                                                              1.00                                                                              38.29                                        ATOM  3378                                                                              C   GLU                                                                               480                                                                               23.955                                                                             41.400                                                                             5.725                                                                              1.00                                                                              31.66                                        ATOM  3379                                                                              O   GLU                                                                               480                                                                               23.977                                                                             40.780                                                                             6.787                                                                              1.00                                                                              34.86                                        ATOM  3380                                                                              N   CYS                                                                               481                                                                               23.077                                                                             42.373                                                                             5.453                                                                              1.00                                                                              32.22                                        ATOM  3381                                                                              CA  CYS                                                                               481                                                                               22.013                                                                             42.740                                                                             6.391                                                                              1.00                                                                              31.34                                        ATOM  3382                                                                              CB  CYS                                                                               481                                                                               21.725                                                                             44.221                                                                             6.334                                                                              1.00                                                                              27.71                                        ATOM  3383                                                                              SG  CYS                                                                               481                                                                               23.102                                                                             45.167                                                                             6.880                                                                              1.00                                                                              33.86                                        ATOM  3384                                                                              C   CYS                                                                               481                                                                               20.719                                                                             42.008                                                                             6.158                                                                              1.00                                                                              33.16                                        ATOM  3385                                                                              O   CYS                                                                               481                                                                               20.363                                                                             41.713                                                                             5.027                                                                              1.00                                                                              36.23                                        ATOM  3386                                                                              N   PHE                                                                               482                                                                               20.033                                                                             41.691                                                                             7.247                                                                              1.00                                                                              34.11                                        ATOM  3387                                                                              CA  PHE                                                                               482                                                                               18.753                                                                             41.009                                                                             7.206                                                                              1.00                                                                              30.22                                        ATOM  3388                                                                              CB  PHE                                                                               482                                                                               18.845                                                                             39.637                                                                             7.849                                                                              1.00                                                                              34.49                                        ATOM  3389                                                                              CG  PHE                                                                               482                                                                               19.608                                                                             38.641                                                                             7.023                                                                              1.00                                                                              40.80                                        ATOM  3390                                                                              CD1 PHE                                                                               482                                                                               20.998                                                                             38.659                                                                             6.989                                                                              1.00                                                                              42.96                                        ATOM  3391                                                                              CD2 PHE                                                                               482                                                                               18.937                                                                             37.683                                                                             6.265                                                                              1.00                                                                              46.84                                        ATOM  3392                                                                              CE1 PHE                                                                               482                                                                               21.717                                                                             37.738                                                                             6.212                                                                              1.00                                                                              44.53                                        ATOM  3393                                                                              CE2 PHE                                                                               482                                                                               19.646                                                                             36.751                                                                             5.478                                                                              1.00                                                                              47.79                                        ATOM  3394                                                                              CZ  PHE                                                                               482                                                                               21.040                                                                             36.783                                                                             5.456                                                                              1.00                                                                              46.14                                        ATOM  3395                                                                              C   PHE                                                                               482                                                                               17.850                                                                             41.918                                                                             7.987                                                                              1.00                                                                              30.71                                        ATOM  3396                                                                              O   PHE                                                                               482                                                                               18.312                                                                             42.716                                                                             8.798                                                                              1.00                                                                              33.95                                        ATOM  3397                                                                              N   LEU                                                                               483                                                                               16.561                                                                             41.811                                                                             7.758                                                                              1.00                                                                              27.58                                        ATOM  3398                                                                              CA  LEU                                                                               483                                                                               15.647                                                                             42.703                                                                             8.420                                                                              1.00                                                                              27.73                                        ATOM  3399                                                                              CB  LEU                                                                               483                                                                               14.738                                                                             43.377                                                                             7.394                                                                              1.00                                                                              24.99                                        ATOM  3400                                                                              CG  LEU                                                                               483                                                                               15.270                                                                             44.192                                                                             6.226                                                                              1.00                                                                              21.74                                        ATOM  3401                                                                              CD1 LEU                                                                               483                                                                               14.098                                                                             44.627                                                                             5.397                                                                              1.00                                                                              25.27                                        ATOM  3402                                                                              CD2 LEU                                                                               483                                                                               16.019                                                                             45.395                                                                             6.678                                                                              1.00                                                                              21.38                                        ATOM  3403                                                                              C   LEU                                                                               483                                                                               14.778                                                                             41.959                                                                             9.401                                                                              1.00                                                                              31.66                                        ATOM  3404                                                                              O   LEU                                                                               483                                                                               14.371                                                                             40.810                                                                             9.164                                                                              1.00                                                                              31.14                                        ATOM  3405                                                                              N   MET                                                                               484                                                                               14.447                                                                             42.645                                                                             10.481                                                                             1.00                                                                              33.44                                        ATOM  3406                                                                              CA  MET                                                                               484                                                                               13.585                                                                             42.068                                                                             11.479                                                                             1.00                                                                              36.28                                        ATOM  3407                                                                              CB  MET                                                                               484                                                                               13.973                                                                             42.576                                                                             12.866                                                                             1.00                                                                              36.13                                        ATOM  3408                                                                              CG  MET                                                                               484                                                                               15.308                                                                             42.089                                                                             13.352                                                                             1.00                                                                              38.45                                        ATOM  3409                                                                              SD  MET                                                                               484                                                                               15.491                                                                             42.483                                                                             15.082                                                                             1.00                                                                              45.99                                        ATOM  3410                                                                              CE  MET                                                                               484                                                                               16.389                                                                             43.963                                                                             15.012                                                                             1.00                                                                              41.27                                        ATOM  3411                                                                              C   MET                                                                               484                                                                               12.132                                                                             42.427                                                                             11.152                                                                             1.00                                                                              38.11                                        ATOM  3412                                                                              O   MET                                                                               484                                                                               11.852                                                                             43.387                                                                             10.416                                                                             1.00                                                                              41.32                                        ATOM  3413                                                                              N   GLN                                                                               485                                                                               11.219                                                                             41.624                                                                             11.680                                                                             1.00                                                                              42.45                                        ATOM  3414                                                                              CA  GLN                                                                               485                                                                               9.782                                                                              41.819                                                                             11.511                                                                             1.00                                                                              46.46                                        ATOM  3415                                                                              CB  GLN                                                                               485                                                                               9.037                                                                              40.519                                                                             11.822                                                                             1.00                                                                              47.26                                        ATOM  3416                                                                              CG  GLN                                                                               485                                                                               9.396                                                                              39.376                                                                             10.884                                                                             1.00                                                                              48.83                                        ATOM  3417                                                                              CD  GLN                                                                               485                                                                               8.697                                                                              38.093                                                                             11.257                                                                             1.00                                                                              51.68                                        ATOM  3418                                                                              OE1 GLN                                                                               485                                                                               9.325                                                                              37.185                                                                             11.774                                                                             1.00                                                                              56.20                                        ATOM  3419                                                                              NE2 GLN                                                                               485                                                                               7.386                                                                              38.015                                                                             11.014                                                                             1.00                                                                              54.56                                        ATOM  3420                                                                              C   GLN                                                                               485                                                                               9.303                                                                              42.928                                                                             12.446                                                                             1.00                                                                              46.51                                        ATOM  3421                                                                              O   GLN                                                                               485                                                                               10.050                                                                             43.400                                                                             13.307                                                                             1.00                                                                              43.94                                        ATOM  3422                                                                              N   ASP                                                                               486                                                                               8.054                                                                              43.344                                                                             12.278                                                                             1.00                                                                              48.98                                        ATOM  3423                                                                              CA  ASP                                                                               486                                                                               7.502                                                                              44.417                                                                             13.099                                                                             1.00                                                                              51.60                                        ATOM  3424                                                                              CB  ASP                                                                               486                                                                               7.163                                                                              43.889                                                                             14.498                                                                             1.00                                                                              55.79                                        ATOM  3425                                                                              CG  ASP                                                                               486                                                                               6.188                                                                              44.788                                                                             15.242                                                                             1.00                                                                              60.84                                        ATOM  3426                                                                              OD1 ASP                                                                               486                                                                               5.712                                                                              45.784                                                                             14.657                                                                             1.00                                                                              66.91                                        ATOM  3427                                                                              OD2 ASP                                                                               486                                                                               5.899                                                                              44.500                                                                             16.424                                                                             1.00                                                                              65.08                                        ATOM  3428                                                                              C   ASP                                                                               486                                                                               8.507                                                                              45.588                                                                             13.163                                                                             1.00                                                                              50.17                                        ATOM  3429                                                                              O   ASP                                                                               486                                                                               8.714                                                                              46.203                                                                             14.213                                                                             1.00                                                                              51.11                                        ATOM  3430                                                                              N   ARG                                                                               487                                                                               9.168                                                                              45.826                                                                             12.030                                                                             1.00                                                                              49.23                                        ATOM  3431                                                                              CA  ARG                                                                               487                                                                               10.150                                                                             46.895                                                                             11.851                                                                             1.00                                                                              50.67                                        ATOM  3432                                                                              CB  ARG                                                                               487                                                                               9.443                                                                              48.192                                                                             11.482                                                                             1.00                                                                              59.54                                        ATOM  3433                                                                              CG  ARG                                                                               487                                                                               8.846                                                                              48.250                                                                             10.104                                                                             1.00                                                                              69.48                                        ATOM  3434                                                                              CD  ARG                                                                               487                                                                               7.999                                                                              49.490                                                                             10.008                                                                             1.00                                                                              77.95                                        ATOM  3435                                                                              NE  ARG                                                                               487                                                                               7.637                                                                              49.805                                                                             8.634                                                                              1.00                                                                              90.05                                        ATOM  3436                                                                              CZ  ARG                                                                               487                                                                               7.217                                                                              51.006                                                                             8.243                                                                              1.00                                                                              96.14                                        ATOM  3437                                                                              NH1 ARG                                                                               487                                                                               6.905                                                                              51.221                                                                             6.961                                                                              1.00                                                                              99.29                                        ATOM  3438                                                                              NH2 ARG                                                                               487                                                                               7.108                                                                              51.995                                                                             9.138                                                                              1.00                                                                              97.66                                        ATOM  3439                                                                              C   ARG                                                                               487                                                                               11.067                                                                             47.204                                                                             13.017                                                                             1.00                                                                              48.25                                        ATOM  3440                                                                              O   ARG                                                                               487                                                                               11.190                                                                             48.369                                                                             13.405                                                                             1.00                                                                              50.28                                        ATOM  3441                                                                              N   ARG                                                                               488                                                                               11.721                                                                             46.198                                                                             13.580                                                                             1.00                                                                              43.30                                        ATOM  3442                                                                              CA  ARG                                                                               488                                                                               12.622                                                                             46.470                                                                             14.693                                                                             1.00                                                                              44.26                                        ATOM  3443                                                                              CB  ARG                                                                               488                                                                               12.667                                                                             45.285                                                                             15.667                                                                             1.00                                                                              45.30                                        ATOM  3444                                                                              CG  ARG                                                                               488                                                                               11.324                                                                             44.941                                                                             16.242                                                                             1.00                                                                              38.80                                        ATOM  3445                                                                              CD  ARG                                                                               488                                                                               10.692                                                                             46.175                                                                             16.832                                                                             1.00                                                                              34.28                                        ATOM  3446                                                                              NE  ARG                                                                               488                                                                               9.310                                                                              45.889                                                                             17.157                                                                             1.00                                                                              33.22                                        ATOM  3447                                                                              CZ  ARG                                                                               488                                                                               8.922                                                                              45.236                                                                             18.248                                                                             1.00                                                                              34.98                                        ATOM  3448                                                                              NH1 ARG                                                                               488                                                                               9.815                                                                              44.815                                                                             19.131                                                                             1.00                                                                              34.60                                        ATOM  3449                                                                              NH2 ARG                                                                               488                                                                               7.641                                                                              44.928                                                                             18.422                                                                             1.00                                                                              38.53                                        ATOM  3450                                                                              C   ARG                                                                               488                                                                               14.037                                                                             46.883                                                                             14.252                                                                             1.00                                                                              44.49                                        ATOM  3451                                                                              O   ARG                                                                               488                                                                               14.851                                                                             47.349                                                                             15.075                                                                             1.00                                                                              44.38                                        ATOM  3452                                                                              N   GLY                                                                               489                                                                               14.323                                                                             46.738                                                                             12.958                                                                             1.00                                                                              40.82                                        ATOM  3453                                                                              CA  GLY                                                                               489                                                                               15.634                                                                             47.110                                                                             12.461                                                                             1.00                                                                              38.10                                        ATOM  3454                                                                              C   GLY                                                                               489                                                                               16.300                                                                             46.037                                                                             11.622                                                                             1.00                                                                              37.57                                        ATOM  3455                                                                              O   GLY                                                                               489                                                                               15.618                                                                             45.144                                                                             11.094                                                                             1.00                                                                              36.28                                        ATOM  3456                                                                              N   THR                                                                               490                                                                               17.628                                                                             46.125                                                                             11.493                                                                             1.00                                                                              35.19                                        ATOM  3457                                                                              CA  THR                                                                               490                                                                               18.379                                                                             45.152                                                                             10.711                                                                             1.00                                                                              30.90                                        ATOM  3458                                                                              CB  THR                                                                               490                                                                               18.837                                                                             45.747                                                                             9.348                                                                              1.00                                                                              29.73                                        ATOM  3459                                                                              OG1 THR                                                                               490                                                                               20.169                                                                             46.257                                                                             9.440                                                                              1.00                                                                              33.88                                        ATOM  3460                                                                              CG2 THR                                                                               490                                                                               17.924                                                                             46.870                                                                             8.941                                                                              1.00                                                                              24.06                                        ATOM  3461                                                                              C   THR                                                                               490                                                                               19.566                                                                             44.566                                                                             11.478                                                                             1.00                                                                              31.16                                        ATOM  3462                                                                              O   THR                                                                               490                                                                               20.287                                                                             45.296                                                                             12.156                                                                             1.00                                                                              31.36                                        ATOM  3463                                                                              N   ILE                                                                               491                                                                               19.705                                                                             43.235                                                                             11.423                                                                             1.00                                                                              28.86                                        ATOM  3464                                                                              CA  ILE                                                                               491                                                                               20.802                                                                             42.496                                                                             12.073                                                                             1.00                                                                              26.73                                        ATOM  3465                                                                              CB  ILE                                                                               491                                                                               20.320                                                                             41.170                                                                             12.803                                                                             1.00                                                                              26.17                                        ATOM  3466                                                                              CG2 ILE                                                                               491                                                                               20.602                                                                             41.207                                                                             14.292                                                                             1.00                                                                              29.86                                        ATOM  3467                                                                              CG1 ILE                                                                               491                                                                               18.854                                                                             40.882                                                                             12.535                                                                             1.00                                                                              27.37                                        ATOM  3468                                                                              CD1 ILE                                                                               491                                                                               18.659                                                                             39.784                                                                             11.547                                                                             1.00                                                                              32.39                                        ATOM  3469                                                                              C   ILE                                                                               491                                                                               21.786                                                                             42.045                                                                             10.992                                                                             1.00                                                                              24.72                                        ATOM  3470                                                                              O   ILE                                                                               491                                                                               21.402                                                                             41.341                                                                             10.055                                                                             1.00                                                                              27.21                                        ATOM  3471                                                                              N   PRO                                                                               492                                                                               23.041                                                                             42.490                                                                             11.061                                                                             1.00                                                                              23.25                                        ATOM  3472                                                                              CD  PRO                                                                               492                                                                               23.497                                                                             43.732                                                                             11.703                                                                             1.00                                                                              20.04                                        ATOM  3473                                                                              CA  PRO                                                                               492                                                                               24.005                                                                             42.064                                                                             10.036                                                                             1.00                                                                              24.76                                        ATOM  3474                                                                              CB  PRO                                                                               492                                                                               25.050                                                                             43.171                                                                             10.010                                                                             1.00                                                                              23.01                                        ATOM  3475                                                                              CG  PRO                                                                               492                                                                               24.301                                                                             44.338                                                                             10.611                                                                             1.00                                                                              24.54                                        ATOM  3476                                                                              C   PRO                                                                               492                                                                               24.634                                                                             40.677                                                                             10.326                                                                             1.00                                                                              27.40                                        ATOM  3477                                                                              O   PRO                                                                               492                                                                               24.626                                                                             40.210                                                                             11.476                                                                             1.00                                                                              27.66                                        ATOM  3478                                                                              N   PHE                                                                               493                                                                               25.124                                                                             40.027                                                                             9.263                                                                              1.00                                                                              30.29                                        ATOM  3479                                                                              CA  PHE                                                                               493                                                                               25.775                                                                             38.701                                                                             9.293                                                                              1.00                                                                              30.16                                        ATOM  3480                                                                              CB  PHE                                                                               493                                                                               25.033                                                                             37.677                                                                             8.406                                                                              1.00                                                                              36.53                                        ATOM  3481                                                                              CG  PHE                                                                               493                                                                               23.702                                                                             37.212                                                                             8.925                                                                              1.00                                                                              45.55                                        ATOM  3482                                                                              CD1 PHE                                                                               493                                                                               22.830                                                                             38.075                                                                             9.597                                                                              1.00                                                                              52.04                                        ATOM  3483                                                                              CD2 PHE                                                                               493                                                                               23.279                                                                             35.916                                                                             8.660                                                                              1.00                                                                              47.34                                        ATOM  3484                                                                              CE1 PHE                                                                               493                                                                               21.540                                                                             37.651                                                                             9.992                                                                              1.00                                                                              52.95                                        ATOM  3485                                                                              CE2 PHE                                                                               493                                                                               22.007                                                                             35.486                                                                             9.044                                                                              1.00                                                                              51.52                                        ATOM  3486                                                                              CZ  PHE                                                                               493                                                                               21.131                                                                             36.354                                                                             9.713                                                                              1.00                                                                              52.07                                        ATOM  3487                                                                              C   PHE                                                                               493                                                                               27.141                                                                             38.832                                                                             8.601                                                                              1.00                                                                              28.46                                        ATOM  3488                                                                              O   PHE                                                                               493                                                                               27.207                                                                             39.375                                                                             7.490                                                                              1.00                                                                              27.20                                        ATOM  3489                                                                              N   PHE                                                                               494                                                                               28.194                                                                             38.268                                                                             9.193                                                                              1.00                                                                              22.47                                        ATOM  3490                                                                              CA  PHE                                                                               494                                                                               29.525                                                                             38.266                                                                             8.576                                                                              1.00                                                                              21.79                                        ATOM  3491                                                                              CB  PHE                                                                               494                                                                               30.585                                                                             38.704                                                                             9.569                                                                              1.00                                                                              24.52                                        ATOM  3492                                                                              CG  PHE                                                                               494                                                                               30.596                                                                             40.163                                                                             9.819                                                                              1.00                                                                              31.15                                        ATOM  3493                                                                              CD1 PHE                                                                               494                                                                               30.974                                                                             40.662                                                                             11.056                                                                             1.00                                                                              28.30                                        ATOM  3494                                                                              CD2 PHE                                                                               494                                                                               30.267                                                                             41.059                                                                             8.793                                                                              1.00                                                                              33.44                                        ATOM  3495                                                                              CE1 PHE                                                                               494                                                                               31.028                                                                             42.043                                                                             11.265                                                                             1.00                                                                              31.41                                        ATOM  3496                                                                              CE2 PHE                                                                               494                                                                               30.315                                                                             42.445                                                                             8.992                                                                              1.00                                                                              29.26                                        ATOM  3497                                                                              CZ  PHE                                                                               494                                                                               30.700                                                                             42.935                                                                             10.227                                                                             1.00                                                                              25.91                                        ATOM  3498                                                                              C   PHE                                                                               494                                                                               29.882                                                                             36.851                                                                             8.065                                                                              1.00                                                                              24.01                                        ATOM  3499                                                                              O   PHE                                                                               494                                                                               29.352                                                                             35.851                                                                             8.568                                                                              1.00                                                                              20.12                                        ATOM  3500                                                                              N   THR                                                                               495                                                                               30.753                                                                             36.786                                                                             7.057                                                                              1.00                                                                              20.49                                        ATOM  3501                                                                              CA  THR                                                                               495                                                                               31.220                                                                             35.533                                                                             6.467                                                                              1.00                                                                              18.98                                        ATOM  3502                                                                              CB  THR                                                                               495                                                                               30.712                                                                             35.369                                                                             5.053                                                                              1.00                                                                              22.01                                        ATOM  3503                                                                              OG1 THR                                                                               495                                                                               29.297                                                                             35.571                                                                             5.035                                                                              1.00                                                                              19.23                                        ATOM  3504                                                                              CG2 THR                                                                               495                                                                               31.056                                                                             33.962                                                                             4.531                                                                              1.00                                                                              19.98                                        ATOM  3505                                                                              C   THR                                                                               495                                                                               32.745                                                                             35.571                                                                             6.397                                                                              1.00                                                                              19.99                                        ATOM  3506                                                                              O   THR                                                                               495                                                                               33.314                                                                             36.519                                                                             5.857                                                                              1.00                                                                              17.46                                        ATOM  3507                                                                              N   TRP                                                                               496                                                                               33.403                                                                             34.527                                                                             6.893                                                                              1.00                                                                              19.16                                        ATOM  3508                                                                              CA  TRP                                                                               496                                                                               34.858                                                                             34.492                                                                             6.921                                                                              1.00                                                                              19.00                                        ATOM  3509                                                                              CB  TRP                                                                               496                                                                               35.328                                                                             34.416                                                                             8.378                                                                              1.00                                                                              19.02                                        ATOM  3510                                                                              CG  TRP                                                                               496                                                                               34.732                                                                             35.457                                                                             9.277                                                                              1.00                                                                              17.89                                        ATOM  3511                                                                              CD2 TRP                                                                               496                                                                               35.405                                                                             36.601                                                                             9.851                                                                              1.00                                                                              20.54                                        ATOM  3512                                                                              CE2 TRP                                                                               496                                                                               34.438                                                                             37.342                                                                             10.579                                                                             1.00                                                                              20.61                                        ATOM  3513                                                                              CE3 TRP                                                                               496                                                                               36.730                                                                             37.071                                                                             9.825                                                                              1.00                                                                              19.34                                        ATOM  3514                                                                              CD1 TRP                                                                               496                                                                               33.424                                                                             35.543                                                                             9.681                                                                              1.00                                                                              19.86                                        ATOM  3515                                                                              NE1 TRP                                                                               496                                                                               33.241                                                                             36.680                                                                             10.458                                                                             1.00                                                                              23.72                                        ATOM  3516                                                                              CZ2 TRP                                                                               496                                                                               34.756                                                                             38.525                                                                             11.263                                                                             1.00                                                                              18.67                                        ATOM  3517                                                                              CZ3 TRP                                                                               496                                                                               37.044                                                                             38.263                                                                             10.521                                                                             1.00                                                                              15.75                                        ATOM  3518                                                                              CH2 TRP                                                                               496                                                                               36.059                                                                             38.963                                                                             11.223                                                                             1.00                                                                              12.02                                        ATOM  3519                                                                              C   TRP                                                                               496                                                                               35.465                                                                             33.318                                                                             6.147                                                                              1.00                                                                              18.54                                        ATOM  3520                                                                              O   TRP                                                                               496                                                                               34.789                                                                             32.321                                                                             5.914                                                                              1.00                                                                              16.59                                        ATOM  3521                                                                              N   THR                                                                               497                                                                               36.729                                                                             33.459                                                                             5.735                                                                              1.00                                                                              17.86                                        ATOM  3522                                                                              CA  THR                                                                               497                                                                               37.463                                                                             32.391                                                                             5.040                                                                              1.00                                                                              20.19                                        ATOM  3523                                                                              CB  THR                                                                               497                                                                               37.694                                                                             32.650                                                                             3.524                                                                              1.00                                                                              19.90                                        ATOM  3524                                                                              OG1 THR                                                                               497                                                                               38.546                                                                             33.787                                                                             3.320                                                                              1.00                                                                              19.60                                        ATOM  3525                                                                              CG2 THR                                                                               497                                                                               36.390                                                                             32.884                                                                             2.835                                                                              1.00                                                                              18.46                                        ATOM  3526                                                                              C   THR                                                                               497                                                                               38.811                                                                             32.171                                                                             5.773                                                                              1.00                                                                              23.90                                        ATOM  3527                                                                              O   THR                                                                               497                                                                               39.338                                                                             33.085                                                                             6.443                                                                              1.00                                                                              24.61                                        ATOM  3528                                                                              N   HIS                                                                               498                                                                               39.328                                                                             30.947                                                                             5.681                                                                              1.00                                                                              20.24                                        ATOM  3529                                                                              CA  HIS                                                                               498                                                                               40.544                                                                             30.546                                                                             6.355                                                                              1.00                                                                              18.34                                        ATOM  3530                                                                              CB  HIS                                                                               498                                                                               40.721                                                                             29.034                                                                             6.233                                                                              1.00                                                                              17.33                                        ATOM  3531                                                                              CG  HIS                                                                               498                                                                               41.575                                                                             28.440                                                                             7.312                                                                              1.00                                                                              19.72                                        ATOM  3532                                                                              CD2 HIS                                                                               498                                                                               41.296                                                                             28.147                                                                             8.603                                                                              1.00                                                                              17.68                                        ATOM  3533                                                                              ND1 HIS                                                                               498                                                                               42.889                                                                             28.069                                                                             7.112                                                                              1.00                                                                              18.83                                        ATOM  3534                                                                              CE1 HIS                                                                               498                                                                               43.385                                                                             27.578                                                                             8.233                                                                              1.00                                                                              18.42                                        ATOM  3535                                                                              NE2 HIS                                                                               498                                                                               42.438                                                                             27.615                                                                             9.154                                                                              1.00                                                                              20.50                                        ATOM  3536                                                                              C   HIS                                                                               498                                                                               41.795                                                                             31.233                                                                             5.871                                                                              1.00                                                                              19.67                                        ATOM  3537                                                                              O   HIS                                                                               498                                                                               42.023                                                                             31.388                                                                             4.674                                                                              1.00                                                                              22.08                                        ATOM  3538                                                                              N   ARG                                                                               499                                                                               42.679                                                                             31.520                                                                             6.809                                                                              1.00                                                                              21.68                                        ATOM  3539                                                                              CA  ARG                                                                               499                                                                               43.937                                                                             32.177                                                                             6.475                                                                              1.00                                                                              24.21                                        ATOM  3540                                                                              CB  ARG                                                                               499                                                                               44.705                                                                             32.506                                                                             7.753                                                                              1.00                                                                              27.17                                        ATOM  3541                                                                              CG  ARG                                                                               499                                                                               45.003                                                                             31.299                                                                             8.637                                                                              1.00                                                                              33.94                                        ATOM  3542                                                                              CD  ARG                                                                               499                                                                               46.383                                                                             30.756                                                                             8.400                                                                              1.00                                                                              38.30                                        ATOM  3543                                                                              NE  ARG                                                                               499                                                                               46.458                                                                             29.344                                                                             8.771                                                                              1.00                                                                              51.54                                        ATOM  3544                                                                              CZ  ARG                                                                               499                                                                               47.386                                                                             28.500                                                                             8.324                                                                              1.00                                                                              55.23                                        ATOM  3545                                                                              NH1 ARG                                                                               499                                                                               47.369                                                                             27.229                                                                             8.722                                                                              1.00                                                                              57.57                                        ATOM  3546                                                                              NH2 ARG                                                                               499                                                                               48.322                                                                             28.920                                                                             7.473                                                                              1.00                                                                              55.32                                        ATOM  3547                                                                              C   ARG                                                                               499                                                                               44.813                                                                             31.328                                                                             5.556                                                                              1.00                                                                              23.51                                        ATOM  3548                                                                              O   ARG                                                                               499                                                                               45.787                                                                             31.816                                                                             4.999                                                                              1.00                                                                              27.69                                        ATOM  3549                                                                              N   SER                                                                               500                                                                               44.476                                                                             30.060                                                                             5.390                                                                              1.00                                                                              19.69                                        ATOM  3550                                                                              CA  SER                                                                               500                                                                               45.300                                                                             29.227                                                                             4.561                                                                              1.00                                                                              21.75                                        ATOM  3551                                                                              CB  SER                                                                               500                                                                               45.031                                                                             27.736                                                                             4.818                                                                              1.00                                                                              21.16                                        ATOM  3552                                                                              OG  SER                                                                               500                                                                               43.708                                                                             27.365                                                                             4.461                                                                              1.00                                                                              15.96                                        ATOM  3553                                                                              C   SER                                                                               500                                                                               45.178                                                                             29.533                                                                             3.082                                                                              1.00                                                                              25.26                                        ATOM  3554                                                                              O   SER                                                                               500                                                                               46.068                                                                             29.152                                                                             2.323                                                                              1.00                                                                              31.57                                        ATOM  3555                                                                              N   VAL                                                                               501                                                                               44.089                                                                             30.184                                                                             2.656                                                                              1.00                                                                              24.13                                        ATOM  3556                                                                              CA  VAL                                                                               501                                                                               43.888                                                                             30.486                                                                             1.226                                                                              1.00                                                                              21.77                                        ATOM  3557                                                                              CB  VAL                                                                               501                                                                               42.554                                                                             31.137                                                                             0.974                                                                              1.00                                                                              18.09                                        ATOM  3558                                                                              CG1 VAL                                                                               501                                                                               42.479                                                                             31.606                                                                             -0.440                                                                             1.00                                                                              15.04                                        ATOM  3559                                                                              CG2 VAL                                                                               501                                                                               41.437                                                                             30.158                                                                             1.276                                                                              1.00                                                                              18.35                                        ATOM  3560                                                                              C   VAL                                                                               501                                                                               44.976                                                                             31.359                                                                             0.599                                                                              1.00                                                                              25.52                                        ATOM  3561                                                                              O   VAL                                                                               501                                                                               45.155                                                                             32.518                                                                             0.963                                                                              1.00                                                                              31.84                                        ATOM  3562                                                                              N   ASP                                                                               502                                                                               45.666                                                                             30.800                                                                             -0.385                                                                             1.00                                                                              26.11                                        ATOM  3563                                                                              CA  ASP                                                                               502                                                                               46.751                                                                             31.478                                                                             -1.073                                                                             1.00                                                                              25.59                                        ATOM  3564                                                                              CB  ASP                                                                               502                                                                               47.673                                                                             30.432                                                                             -1.694                                                                             1.00                                                                              25.96                                        ATOM  3565                                                                              CG  ASP                                                                               502                                                                               48.924                                                                             31.022                                                                             -2.302                                                                             1.00                                                                              29.25                                        ATOM  3566                                                                              OD1 ASP                                                                               502                                                                               49.141                                                                             32.243                                                                             -2.177                                                                             1.00                                                                              32.80                                        ATOM  3567                                                                              OD2 ASP                                                                               502                                                                               49.702                                                                             30.241                                                                             -2.904                                                                             1.00                                                                              28.44                                        ATOM  3568                                                                              C   ASP                                                                               502                                                                               46.153                                                                             32.319                                                                             -2.170                                                                             1.00                                                                              27.90                                        ATOM  3569                                                                              O   ASP                                                                               502                                                                               45.642                                                                             31.780                                                                             -3.153                                                                             1.00                                                                              29.56                                        ATOM  3570                                                                              N   PHE                                                                               503                                                                               46.230                                                                             33.635                                                                             -2.030                                                                             1.00                                                                              29.10                                        ATOM  3571                                                                              CA  PHE                                                                               503                                                                               45.691                                                                             34.514                                                                             -3.059                                                                             1.00                                                                              29.42                                        ATOM  3572                                                                              CB  PHE                                                                               503                                                                               45.842                                                                             35.970                                                                             -2.639                                                                             1.00                                                                              31.35                                        ATOM  3573                                                                              CG  PHE                                                                               503                                                                               45.414                                                                             36.927                                                                             -3.690                                                                             1.00                                                                              32.60                                        ATOM  3574                                                                              CD1 PHE                                                                               503                                                                               44.084                                                                             37.022                                                                             -4.043                                                                             1.00                                                                              31.44                                        ATOM  3575                                                                              CD2 PHE                                                                               503                                                                               46.351                                                                             37.691                                                                             -4.368                                                                             1.00                                                                              35.02                                        ATOM  3576                                                                              CE1 PHE                                                                               503                                                                               43.682                                                                             37.862                                                                             -5.059                                                                             1.00                                                                              34.84                                        ATOM  3577                                                                              CE2 PHE                                                                               503                                                                               45.965                                                                             38.535                                                                             -5.383                                                                             1.00                                                                              35.77                                        ATOM  3578                                                                              CZ  PHE                                                                               503                                                                               44.623                                                                             38.623                                                                             -5.733                                                                             1.00                                                                              35.90                                        ATOM  3579                                                                              C   PHE                                                                               503                                                                               46.367                                                                             34.296                                                                             -4.430                                                                             1.00                                                                              30.03                                        ATOM  3580                                                                              O   PHE                                                                               503                                                                               45.708                                                                             34.347                                                                             -5.480                                                                             1.00                                                                              30.07                                        ATOM  3581                                                                              N   PHE                                                                               504                                                                               47.667                                                                             34.001                                                                             -4.401                                                                             1.00                                                                              25.40                                        ATOM  3582                                                                              CA  PHE                                                                               504                                                                               48.459                                                                             33.792                                                                             -5.606                                                                             1.00                                                                              20.19                                        ATOM  3583                                                                              CB  PHE                                                                               504                                                                               49.896                                                                             34.175                                                                             -5.308                                                                             1.00                                                                              21.87                                        ATOM  3584                                                                              CG  PHE                                                                               504                                                                               50.033                                                                             35.605                                                                             -4.960                                                                             1.00                                                                              26.09                                        ATOM  3585                                                                              CD1 PHE                                                                               504                                                                               50.089                                                                             36.004                                                                             -3.635                                                                             1.00                                                                              23.60                                        ATOM  3586                                                                              CD2 PHE                                                                               504                                                                               49.954                                                                             36.579                                                                             -5.963                                                                             1.00                                                                              25.37                                        ATOM  3587                                                                              CE1 PHE                                                                               504                                                                               50.051                                                                             37.354                                                                             -3.310                                                                             1.00                                                                              26.79                                        ATOM  3588                                                                              CE2 PHE                                                                               504                                                                               49.914                                                                             37.927                                                                             -5.653                                                                             1.00                                                                              27.28                                        ATOM  3589                                                                              CZ  PHE                                                                               504                                                                               49.959                                                                             38.321                                                                             -4.323                                                                             1.00                                                                              26.34                                        ATOM  3590                                                                              C   PHE                                                                               504                                                                               48.421                                                                             32.462                                                                             -6.321                                                                             1.00                                                                              20.08                                        ATOM  3591                                                                              O   PHE                                                                               504                                                                               49.106                                                                             32.285                                                                             -7.328                                                                             1.00                                                                              19.90                                        ATOM  3592                                                                              N   ASN                                                                               505                                                                               47.650                                                                             31.518                                                                             -5.809                                                                             1.00                                                                              19.82                                        ATOM  3593                                                                              CA  ASN                                                                               505                                                                               47.581                                                                             30.208                                                                             -6.433                                                                             1.00                                                                              19.32                                        ATOM  3594                                                                              CB  ASN                                                                               505                                                                               46.744                                                                             30.294                                                                             -7.702                                                                             1.00                                                                              24.30                                        ATOM  3595                                                                              CG  ASN                                                                               505                                                                               45.284                                                                             30.542                                                                             -7.415                                                                             1.00                                                                              25.23                                        ATOM  3596                                                                              OD1 ASN                                                                               505                                                                               44.874                                                                             30.529                                                                             -6.261                                                                             1.00                                                                              31.04                                        ATOM  3597                                                                              ND2 ASN                                                                               505                                                                               44.488                                                                             30.756                                                                             -8.461                                                                             1.00                                                                              26.30                                        ATOM  3598                                                                              C   ASN                                                                               505                                                                               48.983                                                                             29.683                                                                             -6.756                                                                             1.00                                                                              20.70                                        ATOM  3599                                                                              O   ASN                                                                               505                                                                               49.216                                                                             29.101                                                                             -7.817                                                                             1.00                                                                              20.32                                        ATOM  3600                                                                              N   THR                                                                               506                                                                               49.917                                                                             29.914                                                                             -5.842                                                                             1.00                                                                              16.35                                        ATOM  3601                                                                              CA  THR                                                                               506                                                                               51.305                                                                             29.505                                                                             -6.010                                                                             1.00                                                                              20.86                                        ATOM  3602                                                                              CB  THR                                                                               506                                                                               52.150                                                                             30.067                                                                             -4.801                                                                             1.00                                                                              24.90                                        ATOM  3603                                                                              OG1 THR                                                                               506                                                                               51.926                                                                             31.483                                                                             -4.667                                                                             1.00                                                                              30.23                                        ATOM  3604                                                                              CG2 THR                                                                               506                                                                               53.640                                                                             29.820                                                                             -4.972                                                                             1.00                                                                              22.07                                        ATOM  3605                                                                              C   THR                                                                               506                                                                               51.514                                                                             27.973                                                                             -6.141                                                                             1.00                                                                              23.99                                        ATOM  3606                                                                              O   THR                                                                               506                                                                               50.883                                                                             27.197                                                                             -5.423                                                                             1.00                                                                              27.58                                        ATOM  3607                                                                              N   ILE                                                                               507                                                                               52.354                                                                             27.542                                                                             -7.086                                                                             1.00                                                                              22.61                                        ATOM  3608                                                                              CA  ILE                                                                               507                                                                               52.684                                                                             26.128                                                                             -7.255                                                                             1.00                                                                              18.50                                        ATOM  3609                                                                              CB  ILE                                                                               507                                                                               52.811                                                                             25.719                                                                             -8.720                                                                             1.00                                                                              17.29                                        ATOM  3610                                                                              CG2 ILE                                                                               507                                                                               53.059                                                                             24.277                                                                             -8.808                                                                             1.00                                                                              15.63                                        ATOM  3611                                                                              CG1 ILE                                                                               507                                                                               51.570                                                                             26.091                                                                             -9.523                                                                             1.00                                                                              20.82                                        ATOM  3612                                                                              CD1 ILE                                                                               507                                                                               50.307                                                                             25.413                                                                             -9.066                                                                             1.00                                                                              29.01                                        ATOM  3613                                                                              C   ILE                                                                               507                                                                               54.082                                                                             26.024                                                                             -6.663                                                                             1.00                                                                              22.48                                        ATOM  3614                                                                              O   ILE                                                                               507                                                                               55.009                                                                             26.678                                                                             -7.147                                                                             1.00                                                                              24.75                                        ATOM  3615                                                                              N   ASP                                                                               508                                                                               54.220                                                                             25.237                                                                             -5.598                                                                             1.00                                                                              28.69                                        ATOM  3616                                                                              CA  ASP                                                                               508                                                                               55.490                                                                             25.018                                                                             -4.872                                                                             1.00                                                                              29.24                                        ATOM  3617                                                                              CB  ASP                                                                               508                                                                               55.196                                                                             24.244                                                                             -3.576                                                                             1.00                                                                              30.26                                        ATOM  3618                                                                              CG  ASP                                                                               508                                                                               56.258                                                                             24.441                                                                             -2.513                                                                             1.00                                                                              30.30                                        ATOM  3619                                                                              OD1 ASP                                                                               508                                                                               56.151                                                                             25.441                                                                             -1.789                                                                             1.00                                                                              40.59                                        ATOM  3620                                                                              OD2 ASP                                                                               508                                                                               57.179                                                                             23.608                                                                             -2.368                                                                             1.00                                                                              33.88                                        ATOM  3621                                                                              C   ASP                                                                               508                                                                               56.497                                                                             24.218                                                                             -5.700                                                                             1.00                                                                              28.60                                        ATOM  3622                                                                              O   ASP                                                                               508                                                                               56.116                                                                             23.312                                                                             -6.426                                                                             1.00                                                                              31.91                                        ATOM  3623                                                                              N   ALA                                                                               509                                                                               57.785                                                                             24.472                                                                             -5.518                                                                             1.00                                                                              28.24                                        ATOM  3624                                                                              CA  ALA                                                                               509                                                                               58.805                                                                             23.760                                                                             -6.296                                                                             1.00                                                                              29.33                                        ATOM  3625                                                                              CB  ALA                                                                               509                                                                               60.049                                                                             24.613                                                                             -6.412                                                                             1.00                                                                              35.65                                        ATOM  3626                                                                              C   ALA                                                                               509                                                                               59.201                                                                             22.391                                                                             -5.788                                                                             1.00                                                                              27.56                                        ATOM  3627                                                                              O   ALA                                                                               509                                                                               59.779                                                                             21.599                                                                             -6.547                                                                             1.00                                                                              25.79                                        ATOM  3628                                                                              N   GLU                                                                               510                                                                               58.963                                                                             22.166                                                                             -4.491                                                                             1.00                                                                              27.06                                        ATOM  3629                                                                              CA  GLU                                                                               510                                                                               59.303                                                                             20.920                                                                             -3.783                                                                             1.00                                                                              29.89                                        ATOM  3630                                                                              CB  GLU                                                                               510                                                                               60.020                                                                             21.242                                                                             -2.458                                                                             1.00                                                                              38.97                                        ATOM  3631                                                                              CG  GLU                                                                               510                                                                               61.233                                                                             22.188                                                                             -2.502                                                                             1.00                                                                              49.84                                        ATOM  3632                                                                              CD  GLU                                                                               510                                                                               62.515                                                                             21.514                                                                             -2.997                                                                             1.00                                                                              58.12                                        ATOM  3633                                                                              OE1 GLU                                                                               510                                                                               63.358                                                                             22.221                                                                             -3.599                                                                             1.00                                                                              60.55                                        ATOM  3634                                                                              OE2 GLU                                                                               510                                                                               62.691                                                                             20.286                                                                             -2.779                                                                             1.00                                                                              63.36                                        ATOM  3635                                                                              C   GLU                                                                               510                                                                               58.076                                                                             20.055                                                                             -3.435                                                                             1.00                                                                              29.54                                        ATOM  3636                                                                              O   GLU                                                                               510                                                                               58.046                                                                             18.858                                                                             -3.696                                                                             1.00                                                                              30.98                                        ATOM  3637                                                                              N   LYS                                                                               511                                                                               57.101                                                                             20.655                                                                             -2.764                                                                             1.00                                                                              22.60                                        ATOM  3638                                                                              CA  LYS                                                                               511                                                                               55.905                                                                             19.944                                                                             -2.366                                                                             1.00                                                                              22.05                                        ATOM  3639                                                                              CB  LYS                                                                               511                                                                               55.161                                                                             20.748                                                                             -1.307                                                                             1.00                                                                              26.10                                        ATOM  3640                                                                              CG  LYS                                                                               511                                                                               55.963                                                                             21.228                                                                             -0.151                                                                             1.00                                                                              26.97                                        ATOM  3641                                                                              CD  LYS                                                                               511                                                                               55.046                                                                             21.938                                                                             0.826                                                                              1.00                                                                              27.62                                        ATOM  3642                                                                              CE  LYS                                                                               511                                                                               55.824                                                                             22.589                                                                             1.947                                                                              1.00                                                                              27.53                                        ATOM  3643                                                                              NZ  LYS                                                                               511                                                                               56.428                                                                             23.877                                                                             1.516                                                                              1.00                                                                              38.15                                        ATOM  3644                                                                              C   LYS                                                                               511                                                                               54.900                                                                             19.680                                                                             -3.493                                                                             1.00                                                                              20.67                                        ATOM  3645                                                                              O   LYS                                                                               511                                                                               54.972                                                                             20.269                                                                             -4.573                                                                             1.00                                                                              17.60                                        ATOM  3646                                                                              N   ILE                                                                               512                                                                               53.932                                                                             18.819                                                                             -3.180                                                                             1.00                                                                              19.36                                        ATOM  3647                                                                              CA  ILE                                                                               512                                                                               52.829                                                                             18.484                                                                             -4.068                                                                             1.00                                                                              20.42                                        ATOM  3648                                                                              CB  ILE                                                                               512                                                                               52.170                                                                             17.166                                                                             -3.668                                                                             1.00                                                                              16.67                                        ATOM  3649                                                                              CG2 ILE                                                                               512                                                                               50.863                                                                             16.971                                                                             -4.416                                                                             1.00                                                                              9.97                                         ATOM  3650                                                                              CG1 ILE                                                                               512                                                                               53.148                                                                             16.022                                                                             -3.921                                                                             1.00                                                                              12.77                                        ATOM  3651                                                                              CD1 ILE                                                                               512                                                                               52.728                                                                             14.748                                                                             -3.293                                                                             1.00                                                                              12.13                                        ATOM  3652                                                                              C   ILE                                                                               512                                                                               51.860                                                                             19.607                                                                             -3.748                                                                             1.00                                                                              25.62                                        ATOM  3653                                                                              O   ILE                                                                               512                                                                               51.643                                                                             19.919                                                                             -2.569                                                                             1.00                                                                              26.02                                        ATOM  3654                                                                              N   THR                                                                               513                                                                               51.299                                                                             20.224                                                                             -4.781                                                                             1.00                                                                              23.63                                        ATOM  3655                                                                              CA  THR                                                                               513                                                                               50.398                                                                             21.344                                                                             -4.594                                                                             1.00                                                                              21.04                                        ATOM  3656                                                                              CB  THR                                                                               513                                                                               50.929                                                                             22.537                                                                             -5.378                                                                             1.00                                                                              21.80                                        ATOM  3657                                                                              OG1 THR                                                                               513                                                                               52.250                                                                             22.847                                                                             -4.910                                                                             1.00                                                                              19.60                                        ATOM  3658                                                                              CG2 THR                                                                               513                                                                               50.041                                                                             23.733                                                                             -5.217                                                                             1.00                                                                              16.11                                        ATOM  3659                                                                              C   THR                                                                               513                                                                               48.980                                                                             21.046                                                                             -5.013                                                                             1.00                                                                              21.44                                        ATOM  3660                                                                              O   THR                                                                               513                                                                               48.760                                                                             20.534                                                                             -6.089                                                                             1.00                                                                              22.73                                        ATOM  3661                                                                              N   GLN                                                                               514                                                                               48.024                                                                             21.302                                                                             -4.125                                                                             1.00                                                                              24.53                                        ATOM  3662                                                                              CA  GLN                                                                               514                                                                               46.605                                                                             21.088                                                                             -4.432                                                                             1.00                                                                              24.32                                        ATOM  3663                                                                              CB  GLN                                                                               514                                                                               45.826                                                                             20.522                                                                             -3.230                                                                             1.00                                                                              19.75                                        ATOM  3664                                                                              CG  GLN                                                                               514                                                                               46.008                                                                             19.039                                                                             -2.972                                                                             1.00                                                                              16.42                                        ATOM  3665                                                                              CD  GLN                                                                               514                                                                               44.859                                                                             18.416                                                                             -2.171                                                                             1.00                                                                              17.95                                        ATOM  3666                                                                              OE1 GLN                                                                               514                                                                               44.379                                                                             17.318                                                                             -2.501                                                                             1.00                                                                              13.78                                        ATOM  3667                                                                              NE2 GLN                                                                               514                                                                               44.395                                                                             19.121                                                                             -1.141                                                                             1.00                                                                              10.87                                        ATOM  3668                                                                              C   GLN                                                                               514                                                                               46.004                                                                             22.441                                                                             -4.799                                                                             1.00                                                                              22.49                                        ATOM  3669                                                                              O   GLN                                                                               514                                                                               46.181                                                                             23.397                                                                             -4.047                                                                             1.00                                                                              25.77                                        ATOM  3670                                                                              N   LEU                                                                               515                                                                               45.357                                                                             22.522                                                                             -5.970                                                                             1.00                                                                              20.22                                        ATOM  3671                                                                              CA  LEU                                                                               515                                                                               44.694                                                                             23.734                                                                             -6.442                                                                             1.00                                                                              19.38                                        ATOM  3672                                                                              CB  LEU                                                                               515                                                                               45.116                                                                             24.108                                                                             -7.883                                                                             1.00                                                                              24.66                                        ATOM  3673                                                                              CG  LEU                                                                               515                                                                               44.498                                                                             25.381                                                                             -8.514                                                                             1.00                                                                              19.43                                        ATOM  3674                                                                              CD1 LEU                                                                               515                                                                               44.854                                                                             26.618                                                                             -7.735                                                                             1.00                                                                              17.74                                        ATOM  3675                                                                              CD2 LEU                                                                               515                                                                               44.941                                                                             25.544                                                                             -9.931                                                                             1.00                                                                              20.58                                        ATOM  3676                                                                              C   LEU                                                                               515                                                                               43.197                                                                             23.474                                                                             -6.393                                                                             1.00                                                                              21.82                                        ATOM  3677                                                                              O   LEU                                                                               515                                                                               42.670                                                                             22.664                                                                             -7.172                                                                             1.00                                                                              20.91                                        ATOM  3678                                                                              N   PRO                                                                               516                                                                               42.509                                                                             24.057                                                                             -5.391                                                                             1.00                                                                              23.18                                        ATOM  3679                                                                              CD  PRO                                                                               516                                                                               43.000                                                                             24.926                                                                             -4.299                                                                             1.00                                                                              20.43                                        ATOM  3680                                                                              CA  PRO                                                                               516                                                                               41.062                                                                             23.849                                                                             -5.293                                                                             1.00                                                                              20.71                                        ATOM  3681                                                                              CB  PRO                                                                               516                                                                               40.677                                                                             24.713                                                                             -4.086                                                                             1.00                                                                              22.88                                        ATOM  3682                                                                              CG  PRO                                                                               516                                                                               41.941                                                                             24.755                                                                             -3.249                                                                             1.00                                                                              18.38                                        ATOM  3683                                                                              C   PRO                                                                               516                                                                               40.457                                                                             24.382                                                                             -6.600                                                                             1.00                                                                              21.60                                        ATOM  3684                                                                              O   PRO                                                                               516                                                                               40.820                                                                             25.459                                                                             -7.105                                                                             1.00                                                                              20.78                                        ATOM  3685                                                                              N   VAL                                                                               517                                                                               39.550                                                                             23.624                                                                             -7.174                                                                             1.00                                                                              19.37                                        ATOM  3686                                                                              CA  VAL                                                                               517                                                                               38.964                                                                             24.045                                                                             -8.431                                                                             1.00                                                                              19.42                                        ATOM  3687                                                                              CB  VAL                                                                               517                                                                               38.135                                                                             22.859                                                                             -9.010                                                                             1.00                                                                              17.07                                        ATOM  3688                                                                              CG1 VAL                                                                               517                                                                               36.717                                                                             22.848                                                                             -8.468                                                                             1.00                                                                              18.76                                        ATOM  3689                                                                              CG2 VAL                                                                               517                                                                               38.203                                                                             22.842                                                                             -10.505                                                                            1.00                                                                              19.36                                        ATOM  3690                                                                              C   VAL                                                                               511                                                                               38.206                                                                             25.410                                                                             -8.324                                                                             1.00                                                                              20.59                                        ATOM  3691                                                                              O   VAL                                                                               517                                                                               38.076                                                                             26.146                                                                             -9.307                                                                             1.00                                                                              16.82                                        ATOM  3692                                                                              N   VAL                                                                               518                                                                               37.813                                                                             25.785                                                                             -7.10b                                                                             1.00                                                                              23.40                                        ATOM  3693                                                                              CA  VAL                                                                               518                                                                               37.115                                                                             27.053                                                                             -6.842                                                                             1.00                                                                              19.17                                        ATOM  3694                                                                              CB  VAL                                                                               518                                                                               36.353                                                                             27.093                                                                             -5.486                                                                             1.00                                                                              10.97                                        ATOM  3695                                                                              CG1 VAL                                                                               518                                                                               35.202                                                                             26.153                                                                             -5.513                                                                             1.00                                                                              7.06                                         ATOM  3696                                                                              CG2 VAL                                                                               518                                                                               37.302                                                                             26.810                                                                             -4.333                                                                             1.00                                                                              9.27                                         ATOM  3697                                                                              C   VAL                                                                               518                                                                               38.049                                                                             28.258                                                                             -6.877                                                                             1.00                                                                              21.48                                        ATOM  3698                                                                              O   VAL                                                                               518                                                                               37.595                                                                             29.399                                                                             -6.689                                                                             1.00                                                                              23.23                                        ATOM  3699                                                                              N   LYS                                                                               519                                                                               39.342                                                                             28.022                                                                             -7.089                                                                             1.00                                                                              18.73                                        ATOM  3700                                                                              CA  LYS                                                                               519                                                                               40.297                                                                             29.124                                                                             -7.173                                                                             1.00                                                                              19.19                                        ATOM  3701                                                                              CB  LYS                                                                               519                                                                               41.681                                                                             28.685                                                                             -6.676                                                                             1.00                                                                              21.90                                        ATOM  3702                                                                              CG  LYS                                                                               519                                                                               41.673                                                                             28.268                                                                             -5.224                                                                             1.00                                                                              21.02                                        ATOM  3703                                                                              CD  LYS                                                                               519                                                                               41.574                                                                             29.452                                                                             -4.322                                                                             1.00                                                                              12.82                                        ATOM  3704                                                                              CE  LYS                                                                               519                                                                               42.966                                                                             29.886                                                                             -4.023                                                                             1.00                                                                              12.46                                        ATOM  3705                                                                              NZ  LYS                                                                               519                                                                               42.930                                                                             31.325                                                                             -4.032                                                                             1.00                                                                              21.04                                        ATOM  3706                                                                              C   LYS                                                                               519                                                                               40.376                                                                             29.653                                                                             -8.608                                                                             1.00                                                                              19.96                                        ATOM  3707                                                                              O   LYS                                                                               519                                                                               41.147                                                                             30.566                                                                             -8.897                                                                             1.00                                                                              23.17                                        ATOM  3708                                                                              N   ALA                                                                               520                                                                               39.642                                                                             29.016                                                                             -9.517                                                                             1.00                                                                              21.32                                        ATOM  3709                                                                              CA  ALA                                                                               520                                                                               39.572                                                                             29.439                                                                             -10.916                                                                            1.00                                                                              24.50                                        ATOM  3710                                                                              CB  ALA                                                                               520                                                                               38.624                                                                             28.531                                                                             -11.700                                                                            1.00                                                                              18.52                                        ATOM  3711                                                                              C   ALA                                                                               520                                                                               39.008                                                                             30.844                                                                             -10.906                                                                            1.00                                                                              28.46                                        ATOM  3712                                                                              O   ALA                                                                               520                                                                               38.227                                                                             31.196                                                                             -10.012                                                                            1.00                                                                              31.25                                        ATOM  3713                                                                              N   TYR                                                                               521                                                                               39.373                                                                             31.649                                                                             -11.893                                                                            1.00                                                                              31.66                                        ATOM  3714                                                                              CA  TYR                                                                               521                                                                               38.844                                                                             32.996                                                                             -11.943                                                                            1.00                                                                              30.02                                        ATOM  3715                                                                              CB  TYR                                                                               521                                                                               39.943                                                                             33.981                                                                             -12.295                                                                            1.00                                                                              33.11                                        ATOM  3716                                                                              CG  TYR                                                                               521                                                                               40.519                                                                             33.781                                                                             -13.660                                                                            1.00                                                                              39.15                                        ATOM  3717                                                                              CD1 TYR                                                                               521                                                                               39.878                                                                             34.304                                                                             -14.777                                                                            1.00                                                                              39.69                                        ATOM  3718                                                                              CE1 TYR                                                                               521                                                                               40.423                                                                             34.180                                                                             -16.043                                                                            1.00                                                                              44.05                                        ATOM  3719                                                                              CD2 TYR                                                                               521                                                                               41.733                                                                             33.115                                                                             -13.840                                                                            1.00                                                                              44.01                                        ATOM  3720                                                                              CE2 TYR                                                                               521                                                                               42.299                                                                             32.982                                                                             -15.116                                                                            1.00                                                                              44.87                                        ATOM  3721                                                                              CZ  TYR                                                                               521                                                                               41.635                                                                             33.527                                                                             -16.213                                                                            1.00                                                                              44.96                                        ATOM  3722                                                                              OH  TYR                                                                               521                                                                               42.177                                                                             33.480                                                                             -17.480                                                                            1.00                                                                              46.99                                        ATOM  3723                                                                              C   TYR                                                                               521                                                                               37.663                                                                             33.115                                                                             -12.897                                                                            1.00                                                                              29.31                                        ATOM  3724                                                                              O   TYR                                                                               521                                                                               36.953                                                                             34.115                                                                             -12.892                                                                            1.00                                                                              30.01                                        ATOM  3725                                                                              N   ALA                                                                               522                                                                               37.405                                                                             32.058                                                                             -13.654                                                                            1.00                                                                              27.46                                        ATOM  3726                                                                              CA  ALA                                                                               522                                                                               36.321                                                                             32.062                                                                             -14.626                                                                            1.00                                                                              25.98                                        ATOM  3727                                                                              CB  ALA                                                                               522                                                                               36.836                                                                             32.608                                                                             -15.952                                                                            1.00                                                                              25.45                                        ATOM  3728                                                                              C   ALA                                                                               522                                                                               35.783                                                                             30.654                                                                             -14.814                                                                            1.00                                                                              24.28                                        ATOM  3729                                                                              O   ALA                                                                               522                                                                               36.520                                                                             29.701                                                                             -14.620                                                                            1.00                                                                              28.55                                        ATOM  3730                                                                              N   LEU                                                                               523                                                                               34.501                                                                             30.524                                                                             -15.152                                                                            1.00                                                                              22.39                                        ATOM  3731                                                                              CA  LEU                                                                               523                                                                               33.873                                                                             29.215                                                                             -15.368                                                                            1.00                                                                              25.19                                        ATOM  3732                                                                              CB  LEU                                                                               523                                                                               32.917                                                                             28.831                                                                             -14.244                                                                            1.00                                                                              22.10                                        ATOM  3733                                                                              CG  LEU                                                                               523                                                                               33.289                                                                             28.143                                                                             -12.941                                                                            1.00                                                                              21.99                                        ATOM  3734                                                                              CD1 LEU                                                                               523                                                                               31.973                                                                             27.665                                                                             -12.307                                                                            1.00                                                                              17.94                                        ATOM  3735                                                                              CD2 LEU                                                                               523                                                                               34.212                                                                             26.962                                                                             -13.171                                                                            1.00                                                                              21.88                                        ATOM  3736                                                                              C   LEU                                                                               523                                                                               33.028                                                                             29.278                                                                             -16.617                                                                            1.00                                                                              29.42                                        ATOM  3737                                                                              O   LEU                                                                               523                                                                               32.535                                                                             30.348                                                                             -16.958                                                                            1.00                                                                              34.90                                        ATOM  3738                                                                              N   SER                                                                               524                                                                               32.802                                                                             28.133                                                                             -17.258                                                                            1.00                                                                              30.06                                        ATOM  3739                                                                              CA  SER                                                                               524                                                                               31.998                                                                             28.085                                                                             -18.463                                                                            1.00                                                                              31.24                                        ATOM  3740                                                                              CB  SER                                                                               524                                                                               32.529                                                                             27.015                                                                             -19.437                                                                            1.00                                                                              30.18                                        ATOM  3741                                                                              OG  SER                                                                               524                                                                               31.702                                                                             25.859                                                                             -19.512                                                                            1.00                                                                              33.88                                        ATOM  3742                                                                              C   SER                                                                               524                                                                               30.558                                                                             27.827                                                                             -18.055                                                                            1.00                                                                              34.56                                        ATOM  3743                                                                              O   SER                                                                               524                                                                               30.298                                                                             27.349                                                                             -16.955                                                                            1.00                                                                              35.42                                        ATOM  3744                                                                              N   SER                                                                               525                                                                               29.630                                                                             28.145                                                                             -18.953                                                                            1.00                                                                              40.50                                        ATOM  3745                                                                              CA  SER                                                                               525                                                                               28.186                                                                             27.978                                                                             -18.745                                                                            1.00                                                                              41.55                                        ATOM  3746                                                                              CB  SER                                                                               525                                                                               27.443                                                                             28.284                                                                             -20.053                                                                            1.00                                                                              44.75                                        ATOM  3747                                                                              OG  SER                                                                               525                                                                               28.180                                                                             29.192                                                                             -20.862                                                                            1.00                                                                              50.22                                        ATOM  3748                                                                              C   SER                                                                               525                                                                               27.793                                                                             26.570                                                                             -18.310                                                                            1.00                                                                              41.55                                        ATOM  3749                                                                              O   SER                                                                               525                                                                               26.793                                                                             26.386                                                                             -17.615                                                                            1.00                                                                              41.77                                        ATOM  3750                                                                              N   GLY                                                                               526                                                                               28.565                                                                             25.579                                                                             -18.748                                                                            1.00                                                                              41.99                                        ATOM  3751                                                                              CA  GLY                                                                               526                                                                               28.251                                                                             24.200                                                                             -18.427                                                                            1.00                                                                              42.33                                        ATOM  3752                                                                              C   GLY                                                                               526                                                                               28.766                                                                             23.641                                                                             -17.118                                                                            1.00                                                                              39.74                                        ATOM  3753                                                                              O   GLY                                                                               526                                                                               28.651                                                                             22.443                                                                             -16.887                                                                            1.00                                                                              41.33                                        ATOM  3754                                                                              N   ALA                                                                               527                                                                               29.321                                                                             24.483                                                                             -16.262                                                                            1.00                                                                              35.00                                        ATOM  3755                                                                              CA  ALA                                                                               527                                                                               29.840                                                                             24.010                                                                             -15.005                                                                            1.00                                                                              31.00                                        ATOM  3756                                                                              CB  ALA                                                                               527                                                                               31.339                                                                             24.130                                                                             -15.004                                                                            1.00                                                                              25.11                                        ATOM  3757                                                                              C   ALA                                                                               527                                                                               29.241                                                                             24.865                                                                             -13.917                                                                            1.00                                                                              32.01                                        ATOM  3758                                                                              O   ALA                                                                               527                                                                               28.887                                                                             26.013                                                                             -14.153                                                                            1.00                                                                              35.83                                        ATOM  3759                                                                              N   SER                                                                               528                                                                               29.079                                                                             24.303                                                                             -12.732                                                                            1.00                                                                              31.08                                        ATOM  3760                                                                              CA  SER                                                                               528                                                                               28.546                                                                             25.076                                                                             -11.624                                                                            1.00                                                                              31.31                                        ATOM  3761                                                                              CB  SER                                                                               528                                                                               27.040                                                                             24.870                                                                             -11.516                                                                            1.00                                                                              30.58                                        ATOM  3762                                                                              OG  SER                                                                               528                                                                               26.734                                                                             23.533                                                                             -11.161                                                                            1.00                                                                              36.73                                        ATOM  3763                                                                              C   SER                                                                               528                                                                               29.232                                                                             24.686                                                                             -10.315                                                                            1.00                                                                              29.29                                        ATOM  3764                                                                              O   SER                                                                               528                                                                               29.679                                                                             23.545                                                                             -10.159                                                                            1.00                                                                              26.49                                        ATOM  3765                                                                              N   ILE                                                                               529                                                                               29.409                                                                             25.659                                                                             -9.424                                                                             1.00                                                                              27.83                                        ATOM  3766                                                                              CA  ILE                                                                               529                                                                               30.005                                                                             25.375                                                                             -8.130                                                                             1.00                                                                              27.64                                        ATOM  3767                                                                              CB  ILE                                                                               529                                                                               30.721                                                                             26.596                                                                             -7.498                                                                             1.00                                                                              27.04                                        ATOM  3768                                                                              CG2 ILE                                                                               529                                                                               31.322                                                                             26.216                                                                             -6.134                                                                             1.00                                                                              18.53                                        ATOM  3769                                                                              CG1 ILE                                                                               529                                                                               31.846                                                                             27.094                                                                             -8.415                                                                             1.00                                                                              19.40                                        ATOM  3770                                                                              CD1 ILE                                                                               529                                                                               32.895                                                                             26.065                                                                             -8.767                                                                             1.00                                                                              21.82                                        ATOM  3771                                                                              C   ILE                                                                               529                                                                               28.834                                                                             24.871                                                                             -7.275                                                                             1.00                                                                              30.57                                        ATOM  3772                                                                              O   ILE                                                                               529                                                                               27.726                                                                             25.411                                                                             -7.288                                                                             1.00                                                                              32.70                                        ATOM  3773                                                                              N   ILE                                                                               530                                                                               29.084                                                                             23.801                                                                             -6.556                                                                             1.00                                                                              31.83                                        ATOM  3774                                                                              CA  ILE                                                                               530                                                                               28.059                                                                             23.163                                                                             -5.786                                                                             1.00                                                                              31.82                                        ATOM  3775                                                                              CB  ILE                                                                               530                                                                               27.571                                                                             21.955                                                                             -6.653                                                                             1.00                                                                              32.98                                        ATOM  3776                                                                              CG2 ILE                                                                               530                                                                               27.538                                                                             20.628                                                                             -5.926                                                                             1.00                                                                              32.68                                        ATOM  3777                                                                              CG1 ILE                                                                               530                                                                               26.272                                                                             22.355                                                                             -7.338                                                                             1.00                                                                              39.74                                        ATOM  3778                                                                              CD1 ILE                                                                               530                                                                               25.682                                                                             21.281                                                                             -8.215                                                                             1.00                                                                              51.04                                        ATOM  3779                                                                              C   ILE                                                                               530                                                                               28.594                                                                             22.862                                                                             -4.382                                                                             1.00                                                                              33.34                                        ATOM  3780                                                                              O   ILE                                                                               530                                                                               29.791                                                                             23.012                                                                             -4.129                                                                             1.00                                                                              34.98                                        ATOM  3781                                                                              N   GLU                                                                               531                                                                               27.705                                                                             22.578                                                                             -3.441                                                                             1.00                                                                              31.94                                        ATOM  3782                                                                              CA  GLU                                                                               531                                                                               28.123                                                                             22.303                                                                             -2.083                                                                             1.00                                                                              34.44                                        ATOM  3783                                                                              CB  GLU                                                                               531                                                                               26.929                                                                             22.278                                                                             -1.159                                                                             1.00                                                                              45.98                                        ATOM  3784                                                                              CG  GLU                                                                               531                                                                               26.914                                                                             23.434                                                                             -0.196                                                                             1.00                                                                              66.36                                        ATOM  3785                                                                              CD  GLU                                                                               531                                                                               26.232                                                                             23.083                                                                             1.115                                                                              1.00                                                                              77.90                                        ATOM  3786                                                                              OE1 GLU                                                                               531                                                                               24.979                                                                             22.972                                                                             1.130                                                                              1.00                                                                              81.37                                        ATOM  3787                                                                              OE2 GLU                                                                               531                                                                               26.962                                                                             22.911                                                                             2.124                                                                              1.00                                                                              82.42                                        ATOM  3788                                                                              C   GLU                                                                               531                                                                               28.895                                                                             21.012                                                                             -1.933                                                                             1.00                                                                              32.72                                        ATOM  3789                                                                              O   GLU                                                                               531                                                                               28.470                                                                             19.961                                                                             -2.401                                                                             1.00                                                                              29.66                                        ATOM  3790                                                                              N   GLY                                                                               532                                                                               30.021                                                                             21.093                                                                             -1.232                                                                             1.00                                                                              30.18                                        ATOM  3791                                                                              CA  GLY                                                                               532                                                                               30.846                                                                             19.927                                                                             -1.030                                                                             1.00                                                                              27.98                                        ATOM  3792                                                                              C   GLY                                                                               532                                                                               30.138                                                                             18.922                                                                             -0.153                                                                             1.00                                                                              29.77                                        ATOM  3793                                                                              O   GLY                                                                               532                                                                               29.254                                                                             19.277                                                                             0.632                                                                              1.00                                                                              29.92                                        ATOM  3794                                                                              N   PRO                                                                               533                                                                               30.529                                                                             17.651                                                                             -0.251                                                                             1.00                                                                              28.01                                        ATOM  3795                                                                              CD  PRO                                                                               533                                                                               31.657                                                                             17.234                                                                             -1.095                                                                             1.00                                                                              26.16                                        ATOM  3796                                                                              CA  PRO                                                                               533                                                                               29.991                                                                             16.517                                                                             0.499                                                                              1.00                                                                              28.35                                        ATOM  3797                                                                              CB  PRO                                                                               533                                                                               30.744                                                                             15.341                                                                             -0.105                                                                             1.00                                                                              30.57                                        ATOM  3798                                                                              CG  PRO                                                                               533                                                                               32.064                                                                             15.941                                                                             -0.451                                                                             1.00                                                                              31.83                                        ATOM  3799                                                                              C   PRO                                                                               533                                                                               30.261                                                                             16.645                                                                             2.000                                                                              1.00                                                                              28.68                                        ATOM  3800                                                                              O   PRO                                                                               533                                                                               29.501                                                                             16.132                                                                             2.846                                                                              1.00                                                                              30.87                                        ATOM  3801                                                                              N   GLY                                                                               534                                                                               31.365                                                                             17.301                                                                             2.333                                                                              1.00                                                                              26.38                                        ATOM  3802                                                                              CA  GLY                                                                               534                                                                               31.669                                                                             17.488                                                                             3.734                                                                              1.00                                                                              22.29                                        ATOM  3803                                                                              C   GLY                                                                               534                                                                               33.105                                                                             17.254                                                                             4.099                                                                              1.00                                                                              22.73                                        ATOM  3804                                                                              O   GLY                                                                               534                                                                               33.609                                                                             17.901                                                                             5.014                                                                              1.00                                                                              24.94                                        ATOM  3805                                                                              N   PHE                                                                               535                                                                               33.772                                                                             16.350                                                                             3.386                                                                              1.00                                                                              20.12                                        ATOM  3806                                                                              CA  PHE                                                                               535                                                                               35.165                                                                             16.021                                                                             3.690                                                                              1.00                                                                              18.54                                        ATOM  3807                                                                              CB  PHE                                                                               535                                                                               35.314                                                                             14.500                                                                             3.811                                                                              1.00                                                                              15.96                                        ATOM  3808                                                                              CG  PHE                                                                               535                                                                               34.747                                                                             13.766                                                                             2.642                                                                              1.00                                                                              18.55                                        ATOM  3809                                                                              CD1 PHE                                                                               535                                                                               35.480                                                                             13.633                                                                             1.461                                                                              1.00                                                                              17.25                                        ATOM  3810                                                                              CD2 PHE                                                                               535                                                                               33.434                                                                             13.320                                                                             2.667                                                                              1.00                                                                              15.57                                        ATOM  3811                                                                              CE1 PHE                                                                               535                                                                               34.904                                                                             13.080                                                                             0.323                                                                              1.00                                                                              16.51                                        ATOM  3812                                                                              CE2 PHE                                                                               535                                                                               32.853                                                                             12.764                                                                             1.528                                                                              1.00                                                                              17.82                                        ATOM  3813                                                                              CZ  PHE                                                                               535                                                                               33.588                                                                             12.647                                                                             0.357                                                                              1.00                                                                              13.09                                        ATOM  3814                                                                              C   PHE                                                                               535                                                                               36.195                                                                             16.550                                                                             2.686                                                                              1.00                                                                              18.37                                        ATOM  3815                                                                              O   PHE                                                                               535                                                                               37.365                                                                             16.192                                                                             2.771                                                                              1.00                                                                              18.67                                        ATOM  3816                                                                              N   THR                                                                               536                                                                               35.797                                                                             17.366                                                                             1.717                                                                              1.00                                                                              17.09                                        ATOM  3817                                                                              CA  THR                                                                               536                                                                               36.803                                                                             17.850                                                                             0.793                                                                              1.00                                                                              20.39                                        ATOM  3818                                                                              CB  THR                                                                               536                                                                               36.269                                                                             17.966                                                                             -0.610                                                                             1.00                                                                              19.96                                        ATOM  3819                                                                              OG1 THR                                                                               536                                                                               35.193                                                                             18.909                                                                             -0.632                                                                             1.00                                                                              17.87                                        ATOM  3820                                                                              CG2 THR                                                                               536                                                                               35.820                                                                             16.617                                                                             -1.094                                                                             1.00                                                                              19.15                                        ATOM  3821                                                                              C   THR                                                                               536                                                                               37.412                                                                             19.165                                                                             1.262                                                                              1.00                                                                              23.00                                        ATOM  3822                                                                              O   THR                                                                               536                                                                               37.941                                                                             19.960                                                                             0.491                                                                              1.00                                                                              24.82                                        ATOM  3823                                                                              N   GLY                                                                               537                                                                               37.357                                                                             19.402                                                                             2.551                                                                              1.00                                                                              27.76                                        ATOM  3824                                                                              CA  GLY                                                                               537                                                                               37.947                                                                             20.616                                                                             3.033                                                                              1.00                                                                              33.89                                        ATOM  3825                                                                              C   GLY                                                                               537                                                                               37.002                                                                             21.709                                                                             2.752                                                                              1.00                                                                              33.32                                        ATOM  3826                                                                              O   GLY                                                                               537                                                                               35.911                                                                             21.463                                                                             2.287                                                                              1.00                                                                              38.06                                        ATOM  3827                                                                              N   GLY                                                                               538                                                                               37.449                                                                             22.924                                                                             2.980                                                                              1.00                                                                              37.93                                        ATOM  3828                                                                              CA  GLY                                                                               538                                                                               36.582                                                                             24.038                                                                             2.771                                                                              1.00                                                                              42.84                                        ATOM  3829                                                                              C   GLY                                                                               538                                                                               35.777                                                                             23.873                                                                             1.519                                                                              1.00                                                                              47.29                                        ATOM  3830                                                                              O   GLY                                                                               538                                                                               34.558                                                                             24.065                                                                             1.468                                                                              1.00                                                                              54.74                                        ATOM  3831                                                                              N   ASP                                                                               539                                                                               36.477                                                                             23.366                                                                             0.535                                                                              1.00                                                                              45.55                                        ATOM  3832                                                                              CA  ASP                                                                               539                                                                               35.907                                                                             23.168                                                                             -0.756                                                                             1.00                                                                              41.92                                        ATOM  3833                                                                              CB  ASP                                                                               539                                                                               36.785                                                                             22.204                                                                             -1.574                                                                             1.00                                                                              45.21                                        ATOM  3834                                                                              CG  ASP                                                                               539                                                                               37.857                                                                             22.920                                                                             -2.353                                                                             1.00                                                                              49.53                                        ATOM  3835                                                                              OD1 ASP                                                                               539                                                                               38.701                                                                             23.577                                                                             -1.693                                                                             1.00                                                                              44.03                                        ATOM  3836                                                                              OD2 ASP                                                                               539                                                                               37.835                                                                             22.831                                                                             -3.616                                                                             1.00                                                                              51.70                                        ATOM  3837                                                                              C   ASP                                                                               539                                                                               34.450                                                                             22.797                                                                             -0.928                                                                             1.00                                                                              34.91                                        ATOM  3838                                                                              O   ASP                                                                               539                                                                               33.806                                                                             22.129                                                                             -0.116                                                                             1.00                                                                              26.81                                        ATOM  3839                                                                              N   LEU                                                                               540                                                                               33.969                                                                             23.372                                                                             -2.011                                                                             1.00                                                                              29.82                                        ATOM  3840                                                                              CA  LEU                                                                               540                                                                               32.688                                                                             23.155                                                                             -2.588                                                                             1.00                                                                              27.20                                        ATOM  3841                                                                              CB  LEU                                                                               540                                                                               32.005                                                                             24.485                                                                             -2.857                                                                             1.00                                                                              24.69                                        ATOM  3842                                                                              CG  LEU                                                                               540                                                                               31.540                                                                             25.134                                                                             -1.561                                                                             1.00                                                                              20.73                                        ATOM  3843                                                                              CD1 LEU                                                                               540                                                                               30.836                                                                             26.432                                                                             -1.858                                                                             1.00                                                                              25.75                                        ATOM  3844                                                                              CD2 LEU                                                                               540                                                                               30.620                                                                             24.208                                                                             -0.826                                                                             1.00                                                                              15.49                                        ATOM  3845                                                                              C   LEU                                                                               540                                                                               33.270                                                                             22.506                                                                             -3.863                                                                             1.00                                                                              25.13                                        ATOM  3846                                                                              O   LEU                                                                               540                                                                               34.456                                                                             22.645                                                                             -4.147                                                                             1.00                                                                              22.50                                        ATOM  3847                                                                              N   LEU                                                                               541                                                                               32.488                                                                             21.736                                                                             -4.587                                                                             1.00                                                                              26.66                                        ATOM  3848                                                                              CA  LEU                                                                               541                                                                               33.029                                                                             21.059                                                                             -5.759                                                                             1.00                                                                              29.40                                        ATOM  3849                                                                              CB  LEU                                                                               541                                                                               32.562                                                                             19.590                                                                             -5.753                                                                             1.00                                                                              24.79                                        ATOM  3850                                                                              CG  LEU                                                                               541                                                                               32.965                                                                             18.655                                                                             -4.619                                                                             1.00                                                                              19.38                                        ATOM  3851                                                                              CD1 LEU                                                                               541                                                                               32.132                                                                             17.434                                                                             -4.653                                                                             1.00                                                                              23.37                                        ATOM  3852                                                                              CD2 LEU                                                                               541                                                                               34.394                                                                             18.273                                                                             -4.756                                                                             1.00                                                                              26.40                                        ATOM  3853                                                                              C   LEU                                                                               541                                                                               32.437                                                                             21.707                                                                             -6.967                                                                             1.00                                                                              31.74                                        ATOM  3854                                                                              O   LEU                                                                               541                                                                               31.630                                                                             22.614                                                                             -6.830                                                                             1.00                                                                              35.14                                        ATOM  3855                                                                              N   PHE                                                                               542                                                                               32.874                                                                             21.319                                                                             -8.156                                                                             1.00                                                                              33.03                                        ATOM  3856                                                                              CA  PHE                                                                               542                                                                               32.165                                                                             21.827                                                                             -9.305                                                                             1.00                                                                              34.85                                        ATOM  3857                                                                              CB  PHE                                                                               542                                                                               32.946                                                                             22.894                                                                             -10.101                                                                            1.00                                                                              41.04                                        ATOM  3858                                                                              CG  PHE                                                                               542                                                                               33.556                                                                             22.451                                                                             -11.401                                                                            1.00                                                                              41.46                                        ATOM  3859                                                                              CD1 PHE                                                                               542                                                                               34.706                                                                             23.080                                                                             -11.832                                                                            1.00                                                                              43.22                                        ATOM  3860                                                                              CD2 PHE                                                                               542                                                                               33.007                                                                             21.453                                                                             -12.192                                                                            1.00                                                                              43.55                                        ATOM  3861                                                                              CE1 PHE                                                                               542                                                                               35.299                                                                             22.725                                                                             -13.010                                                                            1.00                                                                              50.04                                        ATOM  3862                                                                              CE2 PHE                                                                               542                                                                               33.583                                                                             21.080                                                                             -13.372                                                                            1.00                                                                              51.19                                        ATOM  3863                                                                              CZ  PHE                                                                               542                                                                               34.740                                                                             21.715                                                                             -13.791                                                                            1.00                                                                              54.39                                        ATOM  3864                                                                              C   PHE                                                                               542                                                                               31.563                                                                             20.654                                                                             -10.066                                                                            1.00                                                                              35.15                                        ATOM  3865                                                                              O   PHE                                                                               542                                                                               32.207                                                                             19.597                                                                             -10.215                                                                            1.00                                                                              34.08                                        ATOM  3866                                                                              N   LEU                                                                               543                                                                               30.273                                                                             20.786                                                                             -10.371                                                                            1.00                                                                              32.50                                        ATOM  3867                                                                              CA  LEU                                                                               543                                                                               29.531                                                                             19.770                                                                             -11.111                                                                            1.00                                                                              31.66                                        ATOM  3868                                                                              CB  LEU                                                                               543                                                                               28.057                                                                             19.692                                                                             -10.650                                                                            1.00                                                                              29.24                                        ATOM  3869                                                                              CG  LEU                                                                               543                                                                               27.107                                                                             18.714                                                                             -11.379                                                                            1.00                                                                              31.50                                        ATOM  3870                                                                              CD1 LEU                                                                               543                                                                               27.411                                                                             17.275                                                                             -11.030                                                                            1.00                                                                              30.64                                        ATOM  3871                                                                              CD2 LEU                                                                               543                                                                               25.663                                                                             19.008                                                                             -11.049                                                                            1.00                                                                              31.69                                        ATOM  3872                                                                              C   LEU                                                                               543                                                                               29.610                                                                             20.159                                                                             -12.587                                                                            1.00                                                                              29.13                                        ATOM  3873                                                                              O   LEU                                                                               543                                                                               29.603                                                                             21.340                                                                             -12.933                                                                            1.00                                                                              23.01                                        ATOM  3874                                                                              N   LYS                                                                               544                                                                               29.727                                                                             19.165                                                                             -13.455                                                                            1.00                                                                              32.67                                        ATOM  3875                                                                              CA  LYS                                                                               544                                                                               29.813                                                                             19.442                                                                             -14.876                                                                            1.00                                                                              36.80                                        ATOM  3876                                                                              CB  LYS                                                                               544                                                                               31.056                                                                             18.803                                                                             -15.476                                                                            1.00                                                                              37.11                                        ATOM  3877                                                                              CG  LYS                                                                               544                                                                               31.272                                                                             19.198                                                                             -16.904                                                                            1.00                                                                              37.33                                        ATOM  3878                                                                              CD  LYS                                                                               544                                                                               32.647                                                                             18.823                                                                             -17.345                                                                            1.00                                                                              42.84                                        ATOM  3879                                                                              CE  LYS                                                                               544                                                                               33.093                                                                             17.482                                                                             -16.791                                                                            1.00                                                                              40.97                                        ATOM  3880                                                                              NZ  LYS                                                                               544                                                                               33.958                                                                             17.669                                                                             -15.599                                                                            1.00                                                                              48.30                                        ATOM  3881                                                                              C   LYS                                                                               544                                                                               28.579                                                                             18.979                                                                             -15.606                                                                            1.00                                                                              36.90                                        ATOM  3882                                                                              O   LYS                                                                               544                                                                               28.158                                                                             17.827                                                                             -15.449                                                                            1.00                                                                              32.22                                        ATOM  3883                                                                              N   GLU                                                                               545                                                                               27.993                                                                             19.919                                                                             -16.352                                                                            1.00                                                                              40.87                                        ATOM  3884                                                                              CA  GLU                                                                               545                                                                               26.786                                                                             19.708                                                                             -17.158                                                                            1.00                                                                              49.67                                        ATOM  3885                                                                              CB  GLU                                                                               545                                                                               25.803                                                                             20.872                                                                             -16.986                                                                            1.00                                                                              57.26                                        ATOM  3886                                                                              CG  GLU                                                                               545                                                                               26.062                                                                             21.808                                                                             -15.801                                                                            1.00                                                                              70.57                                        ATOM  3887                                                                              CD  GLU                                                                               545                                                                               25.347                                                                             21.393                                                                             -14.524                                                                            1.00                                                                              79.49                                        ATOM  3888                                                                              OE1 GLU                                                                               545                                                                               24.824                                                                             20.253                                                                             -14.461                                                                            1.00                                                                              82.86                                        ATOM  3889                                                                              OE2 GLU                                                                               545                                                                               25.300                                                                             22.223                                                                             -13.581                                                                            1.00                                                                              84.89                                        ATOM  3890                                                                              C   GLU                                                                               545                                                                               27.132                                                                             19.591                                                                             -18.652                                                                            1.00                                                                              49.21                                        ATOM  3891                                                                              O   GLU                                                                               545                                                                               26.745                                                                             18.634                                                                             -19.318                                                                            1.00                                                                              47.69                                        ATOM  3892                                                                              N   SER                                                                               546                                                                               27.831                                                                             20.593                                                                             -19.176                                                                            1.00                                                                              52.91                                        ATOM  3893                                                                              CA  SER                                                                               546                                                                               28.236                                                                             20.626                                                                             -20.585                                                                            1.00                                                                              56.07                                        ATOM  3894                                                                              CB  SER                                                                               546                                                                               27.641                                                                             21.863                                                                             -21.289                                                                            1.00                                                                              59.19                                        ATOM  3895                                                                              OG  SER                                                                               546                                                                               26.228                                                                             21.789                                                                             -21.462                                                                            1.00                                                                              58.56                                        ATOM  3896                                                                              C   SER                                                                               546                                                                               29.760                                                                             20.718                                                                             -20.596                                                                            1.00                                                                              55.58                                        ATOM  3897                                                                              O   SER                                                                               546                                                                               30.338                                                                             21.272                                                                             -19.659                                                                            1.00                                                                              56.91                                        ATOM  3898                                                                              N   SER                                                                               547                                                                               30.397                                                                             20.214                                                                             -21.654                                                                            1.00                                                                              54.06                                        ATOM  3899                                                                              CA  SER                                                                               547                                                                               31.859                                                                             20.228                                                                             -21.759                                                                            1.00                                                                              54.75                                        ATOM  3900                                                                              CB  SER                                                                               547                                                                               32.336                                                                             18.833                                                                             -22.125                                                                            1.00                                                                              55.22                                        ATOM  3901                                                                              6G  SER                                                                               547                                                                               31.784                                                                             17.902                                                                             -21.213                                                                            1.00                                                                              58.09                                        ATOM  3902                                                                              C   SER                                                                               547                                                                               32.417                                                                             21.251                                                                             -22.753                                                                            1.00                                                                              53.95                                        ATOM  3903                                                                              O   SER                                                                               547                                                                               31.722                                                                             21.596                                                                             -23.705                                                                            1.00                                                                              58.59                                        ATOM  3904                                                                              N   ASN                                                                               548                                                                               33.662                                                                             21.716                                                                             -22.544                                                                            1.00                                                                              52.76                                        ATOM  3905                                                                              CA  ASN                                                                               548                                                                               34.306                                                                             22.712                                                                             -23.428                                                                            1.00                                                                              51.19                                        ATOM  3906                                                                              CB  ASN                                                                               548                                                                               33.366                                                                             23.914                                                                             -23.633                                                                            1.00                                                                              56.75                                        ATOM  3907                                                                              CG  ASN                                                                               548                                                                               32.797                                                                             24.464                                                                             -22.328                                                                            1.00                                                                              58.52                                        ATOM  3908                                                                              OD1 ASN                                                                               548                                                                               33.076                                                                             23.955                                                                             -21.249                                                                            1.00                                                                              58.90                                        ATOM  3909                                                                              ND2 ASN                                                                               548                                                                               32.001                                                                             25.517                                                                             -22.431                                                                            1.00                                                                              67.62                                        ATOM  3910                                                                              C   ASN                                                                               548                                                                               35.720                                                                             23.222                                                                             -23.044                                                                            1.00                                                                              48.17                                        ATOM  3911                                                                              O   ASN                                                                               548                                                                               36.727                                                                             22.791                                                                             -23.663                                                                            1.00                                                                              46.64                                        ATOM  3912                                                                              N   SER                                                                               549                                                                               35.751                                                                             24.252                                                                             -22.199                                                                            1.00                                                                              47.03                                        ATOM  3913                                                                              CA  SER                                                                               549                                                                               36.959                                                                             24.892                                                                             -21.650                                                                            1.00                                                                              38.92                                        ATOM  3914                                                                              CB  SER                                                                               549                                                                               37.491                                                                             25.999                                                                             -22.547                                                                            1.00                                                                              42.82                                        ATOM  3915                                                                              OG  SER                                                                               549                                                                               37.544                                                                             27.249                                                                             -21.877                                                                            1.00                                                                              43.37                                        ATOM  3916                                                                              C   SER                                                                               549                                                                               36.313                                                                             25.450                                                                             -20.394                                                                            1.00                                                                              34.96                                        ATOM  3917                                                                              O   SER                                                                               549                                                                               35.966                                                                             26.625                                                                             -20.271                                                                            1.00                                                                              31.37                                        ATOM  3918                                                                              N   ILE                                                                               550                                                                               36.020                                                                             24.485                                                                             -19.541                                                                            1.00                                                                              32.88                                        ATOM  3919                                                                              CA  ILE                                                                               550                                                                               35.342                                                                             24.657                                                                             -18.291                                                                            1.00                                                                              32.30                                        ATOM  3920                                                                              CB  ILE                                                                               550                                                                               35.247                                                                             23.317                                                                             -17.576                                                                            1.00                                                                              31.25                                        ATOM  3921                                                                              CG2 ILE                                                                               550                                                                               34.300                                                                             23.433                                                                             -16.429                                                                            1.00                                                                              34.89                                        ATOM  3922                                                                              CG1 ILE                                                                               550                                                                               34.674                                                                             22.283                                                                             -18.542                                                                            1.00                                                                              30.40                                        ATOM  3923                                                                              CD1 ILE                                                                               550                                                                               34.896                                                                             20.896                                                                             -18.129                                                                            1.00                                                                              36.71                                        ATOM  3924                                                                              C   ILE                                                                               550                                                                               35.865                                                                             25.727                                                                             -17.364                                                                            1.00                                                                              31.36                                        ATOM  3925                                                                              O   ILE                                                                               550                                                                               35.151                                                                             26.673                                                                             -17.068                                                                            1.00                                                                              36.41                                        ATOM  3926                                                                              N   ALA                                                                               551                                                                               37.109                                                                             25.629                                                                             -16.932                                                                            1.00                                                                              28.45                                        ATOM  3927                                                                              CA  ALA                                                                               551                                                                               37.595                                                                             26.631                                                                             -16.020                                                                            1.00                                                                              23.43                                        ATOM  3928                                                                              CB  ALA                                                                               551                                                                               37.505                                                                             26.093                                                                             -14.589                                                                            1.00                                                                              21.57                                        ATOM  3929                                                                              C   ALA                                                                               551                                                                               38.994                                                                             27.128                                                                             -16.350                                                                            1.00                                                                              22.09                                        ATOM  3930                                                                              O   ALA                                                                               551                                                                               39.793                                                                             26.406                                                                             -16.951                                                                            1.00                                                                              20.34                                        ATOM  3931                                                                              N   LYS                                                                               552                                                                               39.260                                                                             28.387                                                                             -16.008                                                                            1.00                                                                              21.43                                        ATOM  3932                                                                              CA  LYS                                                                               552                                                                               40.561                                                                             28.996                                                                             -16.251                                                                            1.00                                                                              23.88                                        ATOM  3933                                                                              CB  LYS                                                                               552                                                                               40.452                                                                             30.215                                                                             -17.161                                                                            1.00                                                                              23.98                                        ATOM  3934                                                                              CG  LYS                                                                               552                                                                               39.861                                                                             29.894                                                                             -18.522                                                                            1.00                                                                              32.51                                        ATOM  3935                                                                              CD  LYS                                                                               552                                                                               39.797                                                                             31.113                                                                             -19.444                                                                            1.00                                                                              37.66                                        ATOM  3936                                                                              CE  LYS                                                                               552                                                                               38.344                                                                             31.508                                                                             -19.707                                                                            1.00                                                                              46.35                                        ATOM  3937                                                                              Z   LYS                                                                               552                                                                               37.473                                                                             30.364                                                                             -20.166                                                                            1.00                                                                              51.47                                        ATOM  3938                                                                              C   LYS                                                                               552                                                                               41.122                                                                             29.414                                                                             -14.924                                                                            1.00                                                                              24.89                                        ATOM  3939                                                                              O   LYS                                                                               552                                                                               40.390                                                                             29.870                                                                             -14.049                                                                            1.00                                                                              25.99                                        ATOM  3940                                                                              N   PHE                                                                               553                                                                               42.435                                                                             29.291                                                                             -14.790                                                                            1.00                                                                              27.07                                        ATOM  3941                                                                              CA  PHE                                                                               553                                                                               43.116                                                                             29.623                                                                             -13.555                                                                            1.00                                                                              26.79                                        ATOM  3942                                                                              CB  PHE                                                                               553                                                                               43.630                                                                             28.346                                                                             -12.810                                                                            1.00                                                                              28.52                                        ATOM  3943                                                                              CG  PHE                                                                               553                                                                               42.560                                                                             27.342                                                                             -12.397                                                                            1.00                                                                              24.78                                        ATOM  3944                                                                              CD1 PHE                                                                               553                                                                               42.189                                                                             26.305                                                                             -13.251                                                                            1.00                                                                              25.89                                        ATOM  3945                                                                              CD2 PHE                                                                               553                                                                               41.967                                                                             27.407                                                                             -11.135                                                                            1.00                                                                              25.91                                        ATOM  3946                                                                              CE1 PHE                                                                               553                                                                               41.238                                                                             25.352                                                                             -12.853                                                                            1.00                                                                              29.14                                        ATOM  3947                                                                              CE2 PHE                                                                               553                                                                               41.021                                                                             26.461                                                                             -10.726                                                                            1.00                                                                              25.20                                        ATOM  3948                                                                              CZ  PHE                                                                               553                                                                               40.652                                                                             25.433                                                                             -11.584                                                                            1.00                                                                              24.73                                        ATOM  3949                                                                              C   PHE                                                                               553                                                                               44.366                                                                             30.352                                                                             -13.957                                                                            1.00                                                                              25.61                                        ATOM  3950                                                                              O   PHE                                                                               553                                                                               44.850                                                                             30.198                                                                             -15.065                                                                            1.00                                                                              25.20                                        ATOM  3951                                                                              N   LYS                                                                               554                                                                               44.874                                                                             31.171                                                                             -13.062                                                                            1.00                                                                              25.03                                        ATOM  3952                                                                              CA  LYS                                                                               554                                                                               46.157                                                                             31.764                                                                             -13.296                                                                            1.00                                                                              27.95                                        ATOM  3953                                                                              CB  LYS                                                                               554                                                                               46.126                                                                             33.275                                                                             -13.408                                                                            1.00                                                                              30.03                                        ATOM  3954                                                                              CG  LYS                                                                               554                                                                               47.524                                                                             33.810                                                                             -13.114                                                                            1.00                                                                              39.43                                        ATOM  3955                                                                              CD  LYS                                                                               554                                                                               47.787                                                                             35.200                                                                             -13.624                                                                            1.00                                                                              50.21                                        ATOM  3956                                                                              CE  LYS                                                                               554                                                                               49.197                                                                             35.626                                                                             -13.209                                                                            1.00                                                                              54.07                                        ATOM  3957                                                                              NZ  LYS                                                                               554                                                                               49.529                                                                             36.998                                                                             -13.675                                                                            1.00                                                                              56.26                                        ATOM  3958                                                                              C   LYS                                                                               554                                                                               46.907                                                                             31.312                                                                             -12.029                                                                            1.00                                                                              28.45                                        ATOM  3959                                                                              O   LYS                                                                               554                                                                               46.364                                                                             31.376                                                                             -10.913                                                                            1.00                                                                              28.90                                        ATOM  3960                                                                              N   VAL                                                                               555                                                                               48.106                                                                             30.771                                                                             -12.205                                                                            1.00                                                                              26.35                                        ATOM  3961                                                                              CA  VAL                                                                               555                                                                               48.886                                                                             30.278                                                                             -11.082                                                                            1.00                                                                              23.89                                        ATOM  3962                                                                              CB  VAL                                                                               555                                                                               49.143                                                                             28.753                                                                             -11.215                                                                            1.00                                                                              23.89                                        ATdM  3963                                                                              CG1 VAL                                                                               555                                                                               47.848                                                                             27.965                                                                             -11.005                                                                            1.00                                                                              19.80                                        ATOM  3964                                                                              CG2 VAL                                                                               555                                                                               49.693                                                                             28.436                                                                             -12.580                                                                            1.00                                                                              24.10                                        ATOM  3965                                                                              C   VAL                                                                               555                                                                               50.203                                                                             31.036                                                                             -10.957                                                                            1.00                                                                              26.91                                        ATOM  3966                                                                              O   VAL                                                                               555                                                                               50.634                                                                             31.705                                                                             -11.892                                                                            1.00                                                                              29.30                                        ATOM  3967                                                                              N   THR                                                                               556                                                                               50.819                                                                             30.966                                                                             -9.785                                                                             1.00                                                                              27.03                                        ATOM  3968                                                                              CA  THR                                                                               556                                                                               52.077                                                                             31.644                                                                             -9.544                                                                             1.00                                                                              23.49                                        ATOM  3969                                                                              CB  THR                                                                               556                                                                               51.953                                                                             32.599                                                                             -8.367                                                                             1.00                                                                              23.49                                        ATOM  3970                                                                              OG1 THR                                                                               556                                                                               51.091                                                                             33.676                                                                             -8.743                                                                             1.00                                                                              24.29                                        ATOM  3971                                                                              CG2 THR                                                                               556                                                                               53.315                                                                             33.174                                                                             -7.982                                                                             1.00                                                                              22.99                                        ATOM  3972                                                                              C   THR                                                                               556                                                                               53.234                                                                             30.690                                                                             -9.289                                                                             1.00                                                                              26.69                                        ATOM  3973                                                                              O   THR                                                                               556                                                                               53.159                                                                             29.815                                                                             -8.420                                                                             1.00                                                                              27.95                                        ATOM  3974                                                                              N   LEU                                                                               557                                                                               54.317                                                                             30.872                                                                             -10.035                                                                            1.00                                                                              27.71                                        ATOM  3975                                                                              CA  LEU                                                                               557                                                                               55.500                                                                             30.038                                                                             -9.877                                                                             1.00                                                                              30.22                                        ATOM  3976                                                                              CB  LEU                                                                               557                                                                               55.827                                                                             29.295                                                                             -11.180                                                                            1.00                                                                              21.61                                        ATOM  3977                                                                              CG  LEU                                                                               557                                                                               54.939                                                                             28.087                                                                             -11.479                                                                            1.00                                                                              15.95                                        ATOM  3978                                                                              CD1 LEU                                                                               557                                                                               53.843                                                                             28.430                                                                             -12.423                                                                            1.00                                                                              12.75                                        ATOM  3979                                                                              CD2 LEU                                                                               557                                                                               55.766                                                                             26.986                                                                             -12.049                                                                            1.00                                                                              14.32                                        ATOM  3980                                                                              C   LEU                                                                               557                                                                               56.644                                                                             30.948                                                                             -9.506                                                                             1.00                                                                              36.22                                        ATOM  3981                                                                              O   LEU                                                                               557                                                                               56.571                                                                             32.146                                                                             -9.733                                                                             1.00                                                                              42.68                                        ATOM  3982                                                                              N   ASN                                                                               558                                                                               57.646                                                                             30.402                                                                             -8.834                                                                             1.00                                                                              42.11                                        ATOM  3983                                                                              CA  ASN                                                                               558                                                                               58.828                                                                             31.174                                                                             -8.458                                                                             1.00                                                                              43.14                                        ATOM  3984                                                                              CB  ASN                                                                               558                                                                               59.146                                                                             31.050                                                                             -6.950                                                                             1.00                                                                              47.42                                        ATOM  3985                                                                              CG  ASN                                                                               558                                                                               59.198                                                                             29.602                                                                             -6.457                                                                             1.00                                                                              51.14                                        ATOM  3986                                                                              OD1 ASN                                                                               558                                                                               60.280                                                                             29.070                                                                             -6.176                                                                             1.00                                                                              45.86                                        ATOM  3987                                                                              ND2 ASN                                                                               558                                                                               58.022                                                                             28.969                                                                             -6.316                                                                             1.00                                                                              53.80                                        ATOM  3988                                                                              C   ASN                                                                               558                                                                               59.952                                                                             30.628                                                                             -9.328                                                                             1.00                                                                              44.63                                        ATOM  3989                                                                              O   ASN                                                                               558                                                                               59.741                                                                             29.657                                                                             -10.066                                                                            1.00                                                                              46.90                                        ATOM  3990                                                                              N   SER                                                                               559                                                                               61.128                                                                             31.247                                                                             -9.270                                                                             1.00                                                                              43.06                                        ATOM  3991                                                                              CA  SER                                                                               559                                                                               62.270                                                                             30.812                                                                             -10.079                                                                            1.00                                                                              43.61                                        ATOM  3992                                                                              CB  SER                                                                               559                                                                               63.496                                                                             31.652                                                                             -9.741                                                                             1.00                                                                              44.38                                        ATOM  3993                                                                              OG  SER                                                                               559                                                                               63.328                                                                             32.976                                                                             -10.226                                                                            1.00                                                                              50.82                                        ATOM  3994                                                                              C   SER                                                                               559                                                                               62.598                                                                             29.315                                                                             -9.984                                                                             1.00                                                                              41.12                                        ATOM  3995                                                                              O   SER                                                                               559                                                                               62.856                                                                             28.652                                                                             -10.995                                                                            1.00                                                                              41.23                                        ATOM  3996                                                                              N   ALA                                                                               560                                                                               62.598                                                                             28.786                                                                             -8.768                                                                             1.00                                                                              39.09                                        ATOM  3997                                                                              CA  ALA                                                                               560                                                                               62.868                                                                             27.378                                                                             -8.580                                                                             1.00                                                                              34.53                                        ATOM  3998                                                                              CB  ALA                                                                               560                                                                               63.016                                                                             27.069                                                                             -7.113                                                                             1.00                                                                              37.40                                        ATOM  3999                                                                              C   ALA                                                                               560                                                                               61.719                                                                             26.583                                                                             -9.189                                                                             1.00                                                                              33.31                                        ATOM  4000                                                                              O   ALA                                                                               560                                                                               61.945                                                                             25.591                                                                             -9.869                                                                             1.00                                                                              35.43                                        ATOM  4001                                                                              N   ALA                                                                               561                                                                               60.489                                                                             27.052                                                                             -8.999                                                                             1.00                                                                              31.76                                        ATOM  4002                                                                              CA  ALA                                                                               561                                                                               59.330                                                                             26.347                                                                             -9.544                                                                             1.00                                                                              29.93                                        ATOM  4003                                                                              CB  ALA                                                                               561                                                                               58.064                                                                             26.850                                                                             -8.906                                                                             1.00                                                                              28.61                                        ATOM  4004                                                                              C   ALA                                                                               561                                                                               59.249                                                                             26.449                                                                             -11.066                                                                            1.00                                                                              30.20                                        ATOM  4005                                                                              O   ALA                                                                               561                                                                               58.607                                                                             25.630                                                                             -11.713                                                                            1.00                                                                              31.33                                        ATOM  4006                                                                              N   LEU                                                                               562                                                                               59.922                                                                             27.442                                                                             -11.638                                                                            1.00                                                                              32.60                                        ATOM  4007                                                                              CA  LEU                                                                               562                                                                               59.933                                                                             27.635                                                                             -13.088                                                                            1.00                                                                              34.08                                        ATOM  4008                                                                              CB  LEU                                                                               562                                                                               60.209                                                                             29.106                                                                             -13.438                                                                            1.00                                                                              33.88                                        ATOM  4009                                                                              CG  LEU                                                                               562                                                                               59.000                                                                             30.047                                                                             -13.329                                                                            1.00                                                                              34.94                                        ATOM  4010                                                                              CD1 LEU                                                                               562                                                                               59.424                                                                             31.495                                                                             -13.482                                                                            1.00                                                                              35.38                                        ATOM  4011                                                                              CD2 LEU                                                                               562                                                                               57.953                                                                             29.681                                                                             -14.373                                                                            1.00                                                                              32.01                                        ATOM  4612                                                                              C   LEU                                                                               562                                                                               60.899                                                                             26.703                                                                             -13.835                                                                            1.00                                                                              34.58                                        ATOM  4013                                                                              O   LEU                                                                               562                                                                               60.647                                                                             26.331                                                                             -14.979                                                                            1.00                                                                              33.64                                        ATOM  4014                                                                              N   LEU                                                                               563                                                                               61.992                                                                             26.314                                                                             -13.182                                                                            1.00                                                                              37.75                                        ATOM  4015                                                                              CA  LEU                                                                               563                                                                               62.990                                                                             25.406                                                                             -13.773                                                                            1.00                                                                              40.21                                        ATOM  4016                                                                              CB  LEU                                                                               563                                                                               64.290                                                                             25.475                                                                             -12.963                                                                            1.00                                                                              41.41                                        ATOM  4017                                                                              CG  LEU                                                                               563                                                                               65.333                                                                             26.561                                                                             -13.202                                                                            1.00                                                                              42.05                                        ATOM  4018                                                                              CD1 LEU                                                                               563                                                                               66.149                                                                             26.819                                                                             -11.939                                                                            1.00                                                                              43.00                                        ATOM  4019                                                                              CD2 LEU                                                                               563                                                                               66.231                                                                             26.107                                                                             -14.322                                                                            1.00                                                                              44.06                                        ATOM  4020                                                                              C   LEU                                                                               563                                                                               62.492                                                                             23.961                                                                             -13.691                                                                            1.00                                                                              41.90                                        ATOM  4021                                                                              O   LEU                                                                               563                                                                               63.112                                                                             23.034                                                                             -14.212                                                                            1.00                                                                              45.81                                        ATOM  4022                                                                              N   GLN                                                                               564                                                                               61.357                                                                             23.789                                                                             -13.036                                                                            1.00                                                                              41.36                                        ATOM  4023                                                                              CA  GLN                                                                               564                                                                               60.777                                                                             22.487                                                                             -12.774                                                                            1.00                                                                              39.60                                        ATOM  4024                                                                              CB  GLN                                                                               564                                                                               60.189                                                                             22.569                                                                             -11.349                                                                            1.00                                                                              43.83                                        ATOM  4025                                                                              CG  GLN                                                                               564                                                                               60.106                                                                             21.286                                                                             -10.543                                                                            1.00                                                                              50.18                                        ATOM  4026                                                                              CD  GLN                                                                               564                                                                               61.469                                                                             20.739                                                                             -10.147                                                                            1.00                                                                              53.72                                        ATOM  4027                                                                              OE1 GLN                                                                               564                                                                               62.310                                                                             21.439                                                                             -9.558                                                                             1.00                                                                              55.36                                        ATOM  4028                                                                              NE2 GLN                                                                               564                                                                               61.690                                                                             19.470                                                                             -10.460                                                                            1.00                                                                              59.83                                        ATOM  4029                                                                              C   GLN                                                                               564                                                                               59.683                                                                             22.074                                                                             -13.761                                                                            1.00                                                                              35.38                                        ATOM  4030                                                                              O   GLN                                                                               564                                                                               59.102                                                                             22.912                                                                             -14.449                                                                            1.00                                                                              36.05                                        ATOM  4031                                                                              N   ARG                                                                               565                                                                               59.416                                                                             20.771                                                                             -13.818                                                                            1.00                                                                              33.68                                        ATOM  4032                                                                              CA  ARG                                                                               565                                                                               58.333                                                                             20.220                                                                             -14.637                                                                            1.00                                                                              34.60                                        ATOM  4033                                                                              CB  ARG                                                                               565                                                                               58.830                                                                             19.257                                                                             -15.726                                                                            1.00                                                                              38.02                                        ATOM  4034                                                                              CG  ARG                                                                               565                                                                               59.353                                                                             19.990                                                                             -16.363                                                                            1.00                                                                              40.53                                        ATOM  4035                                                                              CD  ARG                                                                               565                                                                               59.021                                                                             19.276                                                                             -18.259                                                                            1.00                                                                              38.89                                        ATOM  4036                                                                              NE  ARG                                                                               565                                                                               58.289                                                                             20.150                                                                             -19.172                                                                            1.00                                                                              40.20                                        ATOM  4037                                                                              CZ  ARG                                                                               565                                                                               57.235                                                                             19.770                                                                             -19.887                                                                            1.00                                                                              42.15                                        ATOM  4038                                                                              NH1 ARG                                                                               565                                                                               56.630                                                                             20.637                                                                             -20.684                                                                            1.00                                                                              42.80                                        ATOM  4039                                                                              NH2 ARG                                                                               565                                                                               56.793                                                                             18.519                                                                             -19.821                                                                            1.00                                                                              45.49                                        ATOM  4040                                                                              C   ARG                                                                               565                                                                               57.386                                                                             19.528                                                                             -13.658                                                                            1.00                                                                              29.39                                        ATOM  4041                                                                              O   ARG                                                                               565                                                                               57.806                                                                             19.117                                                                             -12.573                                                                            1.00                                                                              26.69                                        ATOM  4042                                                                              N   TYR                                                                               566                                                                               56.131                                                                             19.368                                                                             -14.052                                                                            1.00                                                                              27.44                                        ATOM  4043                                                                              CA  TYR                                                                               566                                                                               55.125                                                                             18.807                                                                             -13.162                                                                            1.00                                                                              24.88                                        ATOM  4044                                                                              CB  TYR                                                                               566                                                                               54.241                                                                             19.954                                                                             -12.630                                                                            1.00                                                                              24.68                                        ATOM  4045                                                                              CG  TYR                                                                               566                                                                               55.022                                                                             21.022                                                                             -11.889                                                                            1.00                                                                              24.57                                        ATOM  4046                                                                              CD1 TYR                                                                               566                                                                               55.656                                                                             22.065                                                                             -12.580                                                                            1.00                                                                              23.18                                        ATOM  4047                                                                              CE1 TYR                                                                               566                                                                               56.479                                                                             22.981                                                                             -11.908                                                                            1.00                                                                              22.35                                        ATOM  4048                                                                              CD2 TYR                                                                               566                                                                               55.218                                                                             20.933                                                                             -10.504                                                                            1.00                                                                              21.68                                        ATOM  4049                                                                              CE2 TYR                                                                               566                                                                               56.027                                                                             21.835                                                                             -9.833                                                                             1.00                                                                              23.53                                        ATOM  4050                                                                              CZ  TYR                                                                               566                                                                               56.657                                                                             22.845                                                                             -10.539                                                                            1.00                                                                              19.14                                        ATOM  4051                                                                              OH  TYR                                                                               566                                                                               57.511                                                                             23.668                                                                             -9.870                                                                             1.00                                                                              29.33                                        ATOM  4052                                                                              C   TYR                                                                               566                                                                               54.215                                                                             17.762                                                                             -13.760                                                                            1.00                                                                              26.96                                        ATOM  4053                                                                              O   TYR                                                                               566                                                                               53.827                                                                             17.845                                                                             -14.923                                                                            1.00                                                                              26.47                                        ATOM  4054                                                                              N   ARG                                                                               567                                                                               53.861                                                                             16.785                                                                             -12.937                                                                            1.00                                                                              28.74                                        ATOM  4055                                                                              CA  ARG                                                                               567                                                                               52.938                                                                             15.725                                                                             -13.318                                                                            1.00                                                                              27.05                                        ATOM  4056                                                                              CB  ARG                                                                               567                                                                               53.342                                                                             14.413                                                                             -12.647                                                                            1.00                                                                              25.39                                        ATOM  4057                                                                              CG  ARG                                                                               567                                                                               52.790                                                                             13.157                                                                             -13.294                                                                            1.00                                                                              33.50                                        ATOM  4058                                                                              CD  ARG                                                                               567                                                                               53.135                                                                             11.892                                                                             -12.489                                                                            1.00                                                                              35.21                                        ATOM  4059                                                                              NE  ARG                                                                               567                                                                               52.052                                                                             11.476                                                                             -11.599                                                                            1.00                                                                              37.84                                        ATOM  4060                                                                              CZ  ARG                                                                               567                                                                               52.230                                                                             10.952                                                                             -10.389                                                                            1.00                                                                              37.80                                        ATOM  4061                                                                              NH1 ARG                                                                               567                                                                               51.186                                                                             10.619                                                                             -9.660                                                                             1.00                                                                              36.93                                        ATOM  4062                                                                              NH2 ARG                                                                               567                                                                               53.443                                                                             10.783                                                                             -9.891                                                                             1.00                                                                              42.04                                        ATOM  4063                                                                              C   ARG                                                                               567                                                                               51.645                                                                             16.261                                                                             -12.689                                                                            1.00                                                                              29.34                                        ATOM  4064                                                                              O   ARG                                                                               567                                                                               51.678                                                                             16.847                                                                             -11.607                                                                            1.00                                                                              28.88                                        ATOM  4065                                                                              N   VAL                                                                               568                                                                               50.537                                                                             16.155                                                                             -13.406                                                                            1.00                                                                              29.48                                        ATOM  4066                                                                              CA  VAL                                                                               568                                                                               49.240                                                                             16.616                                                                             -12.929                                                                            1.00                                                                              23.50                                        ATOM  4067                                                                              CB  VAL                                                                               568                                                                               48.517                                                                             17.435                                                                             -14.054                                                                            1.00                                                                              29.72                                        ATOM  4068                                                                              CG1 VAL                                                                               568                                                                               47.083                                                                             17.817                                                                             -13.659                                                                            1.00                                                                              25.49                                        ATOM  4069                                                                              CG2 VAL                                                                               568                                                                               49.309                                                                             18.685                                                                             -14.382                                                                            1.00                                                                              28.25                                        ATOM  4070                                                                              C   VAL                                                                               568                                                                               48.390                                                                             15.395                                                                             -12.545                                                                            1.00                                                                              23.91                                        ATOM  4071                                                                              O   VAL                                                                               568                                                                               48.400                                                                             14.367                                                                             -13.236                                                                            1.00                                                                              26.41                                        ATOM  4072                                                                              N   ARG                                                                               569                                                                               47.707                                                                             15.500                                                                             -11.411                                                                            1.00                                                                              22.32                                        ATOM  4073                                                                              CA  ARG                                                                               569                                                                               46.798                                                                             14.475                                                                             -10.887                                                                            1.00                                                                              21.06                                        ATOM  4074                                                                              CB  ARG                                                                               569                                                                               47.270                                                                             14.042                                                                             -9.543                                                                             1.00                                                                              19.44                                        ATOM  4075                                                                              CG  ARG                                                                               569                                                                               47.930                                                                             12.741                                                                             -9.372                                                                             1.00                                                                              20.01                                        ATOM  4076                                                                              CD  ARG                                                                               569                                                                               47.969                                                                             12.675                                                                             -7.867                                                                             1.00                                                                              16.43                                        ATOM  4077                                                                              NE  ARG                                                                               569                                                                               48.963                                                                             11.790                                                                             -7.329                                                                             1.00                                                                              17.92                                        ATOM  4078                                                                              CZ  ARG                                                                               569                                                                               49.377                                                                             11.807                                                                             -6.069                                                                             1.00                                                                              12.56                                        ATOM  4079                                                                              NH1 ARG                                                                               569                                                                               50.295                                                                             10.928                                                                             -5.686                                                                             1.00                                                                              8.11                                         ATOM  4080                                                                              NH2 ARG                                                                               569                                                                               48.885                                                                             12.683                                                                             -5.215                                                                             1.00                                                                              7.02                                         ATOM  4081                                                                              C   ARG                                                                               569                                                                               45.492                                                                             15.220                                                                             -10.600                                                                            1.00                                                                              22.50                                        ATOM  4082                                                                              O   ARG                                                                               569                                                                               45.535                                                                             16.336                                                                             -10.105                                                                            1.00                                                                              25.09                                        ATOM  4083                                                                              N   ILE                                                                               570                                                                               44.343                                                                             14.598                                                                             -10.799                                                                            1.00                                                                              21.96                                        ATOM  4084                                                                              CA  ILE                                                                               570                                                                               43.072                                                                             15.268                                                                             -10.535                                                                            1.00                                                                              21.79                                        ATOM  4085                                                                              CB  ILE                                                                               570                                                                               42.279                                                                             15.497                                                                             -11.871                                                                            1.00                                                                              24.30                                        ATOM  4086                                                                              CG2 ILE                                                                               570                                                                               40.750                                                                             15.555                                                                             -11.652                                                                            1.00                                                                              21.29                                        ATOM  4087                                                                              CG1 ILE                                                                               570                                                                               42.745                                                                             16.804                                                                             -12.494                                                                            1.00                                                                              21.98                                        ATOM  4088                                                                              CD1 ILE                                                                               570                                                                               43.373                                                                             16.637                                                                             -13.802                                                                            1.00                                                                              22.97                                        ATOM  4089                                                                              C   ILE                                                                               570                                                                               42.240                                                                             14.451                                                                             -9.563                                                                             1.00                                                                              19.98                                        ATOM  4090                                                                              O   ILE                                                                               570                                                                               42.061                                                                             13.258                                                                             -9.775                                                                             1.00                                                                              22.62                                        ATOM  4091                                                                              N   ARG                                                                               571                                                                               41.764                                                                             15.073                                                                             -8.484                                                                             1.00                                                                              22.31                                        ATOM  4092                                                                              CA  ARG                                                                               571                                                                               40.927                                                                             14.380                                                                             -7.502                                                                             1.00                                                                              19.02                                        ATOM  4093                                                                              CB  ARG                                                                               571                                                                               41.173                                                                             14.917                                                                             -6.091                                                                             1.00                                                                              20.56                                        ATOM  4094                                                                              CG  ARG                                                                               571                                                                               40.276                                                                             14.283                                                                             -5.015                                                                             1.00                                                                              30.48                                        ATOM  4095                                                                              CD  ARG                                                                               571                                                                               41.093                                                                             13.628                                                                             -3.905                                                                             1.00                                                                              37.09                                        ATOM  4096                                                                              NE  ARG                                                                               571                                                                               40.302                                                                             13.065                                                                             -2.802                                                                             1.00                                                                              44.17                                        ATOM  4097                                                                              CZ  ARG                                                                               571                                                                               39.627                                                                             13.786                                                                             -1.896                                                                             1.00                                                                              49.87                                        ATOM  4098                                                                              NH1 ARG                                                                               571                                                                               39.607                                                                             15.129                                                                             -1.950                                                                             1.00                                                                              44.30                                        ATOM  4099                                                                              NH2 ARG                                                                               571                                                                               39.057                                                                             13.163                                                                             -0.861                                                                             1.00                                                                              47.17                                        ATOM  4100                                                                              C   ARG                                                                               571                                                                               39.505                                                                             14.657                                                                             -7.982                                                                             1.00                                                                              18.92                                        ATOM  4101                                                                              O   ARG                                                                               571                                                                               39.075                                                                             15.825                                                                             -8.064                                                                             1.00                                                                              15.94                                        ATOM  4102                                                                              N   TYR                                                                               572                                                                               38.784                                                                             13.588                                                                             -8.316                                                                             1.00                                                                              16.89                                        ATOM  4103                                                                              CA  TYR                                                                               572                                                                               37.441                                                                             13.715                                                                             -8.860                                                                             1.00                                                                              14.77                                        ATOM  4104                                                                              CB  TYR                                                                               572                                                                               37.537                                                                             13.636                                                                             -10.385                                                                            1.00                                                                              16.10                                        ATOM  4105                                                                              CG  TYR                                                                               572                                                                               37.920                                                                             12.249                                                                             -10.863                                                                            1.00                                                                              19.08                                        ATOM  4106                                                                              CD1 TYR                                                                               572                                                                               36.942                                                                             11.366                                                                             -11.339                                                                            1.00                                                                              19.90                                        ATOM  4107                                                                              CE1 TYR                                                                               572                                                                               37.245                                                                             10.048                                                                             -11.669                                                                            1.00                                                                              16.28                                        ATOM  4108                                                                              CD2 TYR                                                                               572                                                                               39.237                                                                             11.778                                                                             -10.742                                                                            1.00                                                                              20.80                                        ATOM  4109                                                                              CE2 TYR                                                                               572                                                                               39.561                                                                             10.445                                                                             -11.070                                                                            1.00                                                                              22.00                                        ATOM  4110                                                                              CZ  TYR                                                                               572                                                                               38.551                                                                             9.582                                                                              -11.525                                                                            1.00                                                                              21.96                                        ATOM  4111                                                                              OH  TYR                                                                               572                                                                               38.799                                                                             8.241                                                                              -11.769                                                                            1.00                                                                              17.33                                        ATOM  4112                                                                              C   TYR                                                                               572                                                                               36.551                                                                             12.579                                                                             -8.398                                                                             1.00                                                                              16.70                                        ATOM  4113                                                                              O   TYR                                                                               572                                                                               36.994                                                                             11.674                                                                             -7.706                                                                             1.00                                                                              17.05                                        ATOM  4114                                                                              N   ALA                                                                               573                                                                               35.298                                                                             12.634                                                                             -8.830                                                                             1.00                                                                              17.73                                        ATOM  4115                                                                              CA  ALA                                                                               573                                                                               34.280                                                                             11.618                                                                             -8.558                                                                             1.00                                                                              18.71                                        ATOM  4116                                                                              CB  ALA                                                                               573                                                                               33.439                                                                             12.013                                                                             -7.357                                                                             1.00                                                                              15.72                                        ATOM  4117                                                                              C   ALA                                                                               573                                                                               33.440                                                                             11.645                                                                             -9.845                                                                             1.00                                                                              19.61                                        ATOM  4118                                                                              O   ALA                                                                               573                                                                               33.025                                                                             12.709                                                                             -10.291                                                                            1.00                                                                              21.78                                        ATOM  4119                                                                              N   SER                                                                               574                                                                               33.174                                                                             10.496                                                                             -10.444                                                                            1.00                                                                              20.78                                        ATOM  4120                                                                              CA  SER                                                                               574                                                                               32.442                                                                             10.490                                                                             -11.702                                                                            1.00                                                                              18.28                                        ATOM  4121                                                                              CB  SER                                                                               574                                                                               33.441                                                                             10.726                                                                             -12.839                                                                            1.00                                                                              20.54                                        ATOM  4122                                                                              OG  SER                                                                               574                                                                               32.924                                                                             10.279                                                                             -14.066                                                                            1.00                                                                              18.88                                        ATOM  4123                                                                              C   SER                                                                               574                                                                               31.695                                                                             9.201                                                                              -11.954                                                                            1.00                                                                              19.42                                        ATOM  4124                                                                              O   SER                                                                               574                                                                               32.129                                                                             8.135                                                                              -11.518                                                                            1.00                                                                              20.80                                        ATOM  4125                                                                              N   THR                                                                               575                                                                               30.594                                                                             9.292                                                                              -12.694                                                                            1.00                                                                              17.84                                        ATOM  4126                                                                              CA  THR                                                                               575                                                                               29.802                                                                             8.107                                                                              -13.017                                                                            1.00                                                                              20.27                                        ATOM  4127                                                                              CB  THR                                                                               575                                                                               28.302                                                                             8.391                                                                              -13.007                                                                            1.00                                                                              16.07                                        ATOM  4128                                                                              OG1 THR                                                                               575                                                                               28.007                                                                             9.424                                                                              -13.948                                                                            1.00                                                                              22.01                                        ATOM  4129                                                                              CG2 THR                                                                               575                                                                               27.875                                                                             8.857                                                                              -11.661                                                                            1.00                                                                              20.62                                        ATOM  4130                                                                              C   THR                                                                               575                                                                               30.138                                                                             7.475                                                                              -14.364                                                                            1.00                                                                              26.24                                        ATOM  4131                                                                              O   THR                                                                               575                                                                               29.468                                                                             6.511                                                                              -14.758                                                                            1.00                                                                              32.16                                        ATOM  4132                                                                              N   THR                                                                               576                                                                               31.146                                                                             8.009                                                                              -15.065                                                                            1.00                                                                              25.53                                        ATOM  4133                                                                              CA  THR                                                                               576                                                                               31.574                                                                             7.489                                                                              -16.365                                                                            1.00                                                                              28.39                                        ATOM  4134                                                                              CB  THR                                                                               576                                                                               30.923                                                                             8.210                                                                              -17.577                                                                            1.00                                                                              31.77                                        ATOM  4135                                                                              OG1 THR                                                                               576                                                                               30.795                                                                             9.612                                                                              -17.303                                                                            1.00                                                                              31.40                                        ATOM  4136                                                                              CG2 THR                                                                               576                                                                               29.604                                                                             7.570                                                                              -17.985                                                                            1.00                                                                              34.68                                        ATOM  4137                                                                              C   THR                                                                               576                                                                               33.029                                                                             7.746                                                                              -16.597                                                                            1.00                                                                              29.87                                        ATOM  4138                                                                              O   THR                                                                               576                                                                               33.623                                                                             8.601                                                                              -15.950                                                                            1.00                                                                              34.81                                        ATOM  4139                                                                              N   ASN                                                                               577                                                                               33.585                                                                             7.029                                                                              -17.567                                                                            1.00                                                                              31.68                                        ATOM  4140                                                                              CA  ASN                                                                               577                                                                               34.965                                                                             7.234                                                                              -17.962                                                                            1.00                                                                              32.54                                        ATOM  4141                                                                              CB  ASN                                                                               577                                                                               35.513                                                                             6.018                                                                              -18.723                                                                            1.00                                                                              38.35                                        ATOM  4142                                                                              CG  ASN                                                                               577                                                                               35.575                                                                             4.757                                                                              -17.863                                                                            1.00                                                                              45.89                                        ATOM  4143                                                                              OD1 ASN                                                                               577                                                                               34.795                                                                             4.587                                                                              -16.924                                                                            1.00                                                                              53.01                                        ATOM  4144                                                                              ND2 ASN                                                                               577                                                                               36.505                                                                             3.863                                                                              -18.185                                                                            1.00                                                                              47.10                                        ATOM  4145                                                                              C   ASN                                                                               577                                                                               34.830                                                                             8.438                                                                              -18.898                                                                            1.00                                                                              29.69                                        ATOM  4146                                                                              O   ASN                                                                               577                                                                               33.765                                                                             8.651                                                                              -19.490                                                                            1.00                                                                              29.69                                        ATOM  4147                                                                              N   LEU                                                                               578                                                                               35.876                                                                             9.243                                                                              -18.999                                                                            1.00                                                                              25.93                                        ATOM  4148                                                                              CA  LEU                                                                               578                                                                               35.851                                                                             10.419                                                                             -19.856                                                                            1.00                                                                              24.60                                        ATOM  4149                                                                              CB  LEU                                                                               578                                                                               34.984                                                                             11.510                                                                             -19.216                                                                            1.00                                                                              24.64                                        ATOM  4150                                                                              CG  LEU                                                                               578                                                                               34.712                                                                             12.813                                                                             -19.972                                                                            1.00                                                                              22.62                                        ATOM  4151                                                                              CD1 LEU                                                                               578                                                                               33.537                                                                             12.583                                                                             -20.895                                                                            1.00                                                                              27.61                                        ATOM  4152                                                                              CD2 LEU                                                                               578                                                                               34.365                                                                             13.949                                                                             -19.023                                                                            1.00                                                                              21.47                                        ATOM  4153                                                                              C   LEU                                                                               578                                                                               37.278                                                                             10.923                                                                             -19.968                                                                            1.00                                                                              24.35                                        ATOM  4154                                                                              O   LEU                                                                               578                                                                               38.134                                                                             10.526                                                                             -19.191                                                                            1.00                                                                              29.74                                        ATOM  4155                                                                              N   ARG                                                                               579                                                                               37.560                                                                             11.745                                                                             -20.963                                                                            1.00                                                                              22.26                                        ATOM  4156                                                                              CA  ARG                                                                               579                                                                               38.888                                                                             12.318                                                                             -21.086                                                                            1.00                                                                              20.20                                        ATOM  4157                                                                              CB  ARG                                                                               579                                                                               39.371                                                                             12.315                                                                             -22.528                                                                            1.00                                                                              22.68                                        ATOM  4158                                                                              CG  ARG                                                                               579                                                                               39.639                                                                             10.946                                                                             -23.095                                                                            1.00                                                                              28.06                                        ATOM  4159                                                                              CD  ARG                                                                               579                                                                               40.144                                                                             11.045                                                                             -24.534                                                                            1.00                                                                              27.95                                        ATOM  4160                                                                              NE  ARG                                                                               579                                                                               39.100                                                                             11.464                                                                             -25.456                                                                            1.00                                                                              26.06                                        ATOM  4161                                                                              CZ  ARG                                                                               579                                                                               39.351                                                                             12.036                                                                             -26.621                                                                            1.00                                                                              27.53                                        ATOM  4162                                                                              NH1 ARG                                                                               579                                                                               40.606                                                                             12.248                                                                             -26.993                                                                            1.00                                                                              28.69                                        ATOM  4163                                                                              NH2 ARG                                                                               579                                                                               38.354                                                                             12.417                                                                             -27.401                                                                            1.00                                                                              29.94                                        ATOM  4164                                                                              C   ARG                                                                               579                                                                               38.750                                                                             13.752                                                                             -20.664                                                                            1.00                                                                              18.59                                        ATOM  4165                                                                              O   ARG                                                                               579                                                                               37.763                                                                             14.411                                                                             -20.995                                                                            1.00                                                                              20.40                                        ATOM  4166                                                                              N   LEU                                                                               580                                                                               39.721                                                                             14.235                                                                             -19.920                                                                            1.00                                                                              19.86                                        ATOM  4167                                                                              CA  LEU                                                                               580                                                                               39.738                                                                             15.617                                                                             -19.481                                                                            1.00                                                                              23.93                                        ATOM  4168                                                                              CB  LEU                                                                               580                                                                               39.916                                                                             15.744                                                                             -17.970                                                                            1.00                                                                              28.52                                        ATOM  4169                                                                              CG  LEU                                                                               580                                                                               38.899                                                                             15.198                                                                             -16.973                                                                            1.00                                                                              28.66                                        ATOM  4170                                                                              CD1 LEU                                                                               580                                                                               39.238                                                                             15.819                                                                             -15.627                                                                            1.00                                                                              34.80                                        ATOM  4171                                                                              CD2 LEU                                                                               580                                                                               37.484                                                                             15.569                                                                             -17.365                                                                            1.00                                                                              29.91                                        ATOM  4172                                                                              C   LEU                                                                               580                                                                               40.984                                                                             16.140                                                                             -20.148                                                                            1.00                                                                              25.88                                        ATOM  4173                                                                              O   LEU                                                                               580                                                                               41.891                                                                             15.363                                                                             -20.481                                                                            1.00                                                                              28.77                                        ATOM  4174                                                                              N   PHE                                                                               581                                                                               41.051                                                                             17.445                                                                             -20.334                                                                            1.00                                                                              24.42                                        ATOM  4175                                                                              CA  PHE                                                                               581                                                                               42.207                                                                             18.039                                                                             -20.982                                                                            1.00                                                                              23.21                                        ATOM  4176                                                                              CB  PHE                                                                               581                                                                               41.802                                                                             18.666                                                                             -22.324                                                                            1.00                                                                              23.26                                        ATOM  4177                                                                              CG  PHE                                                                               581                                                                               40.999                                                                             17.757                                                                             -23.193                                                                            1.00                                                                              23.59                                        ATOM  4178                                                                              CD1 PHE                                                                               581                                                                               39.694                                                                             18.090                                                                             -23.540                                                                            1.00                                                                              24.13                                        ATOM  4179                                                                              CD2 PHE                                                                               581                                                                               41.528                                                                             16.541                                                                             -23.623                                                                            1.00                                                                              21.60                                        ATOM  4180                                                                              CE1 PHE                                                                               581                                                                               38.917                                                                             17.225                                                                             -24.294                                                                            1.00                                                                              17.92                                        ATOM  4181                                                                              CE2 PHE                                                                               581                                                                               40.766                                                                             15.668                                                                             -24.375                                                                            1.00                                                                              20.87                                        ATOM  4182                                                                              CZ  PHE                                                                               581                                                                               39.452                                                                             16.007                                                                             -24.711                                                                            1.00                                                                              20.99                                        ATOM  4183                                                                              C   PHE                                                                               581                                                                               42.719                                                                             19.128                                                                             -20.092                                                                            1.00                                                                              18.97                                        ATOM  4184                                                                              O   PHE                                                                               581                                                                               41.943                                                                             19.854                                                                             -19.505                                                                            1.00                                                                              21.90                                        ATOM  4185                                                                              N   VAL                                                                               582                                                                               44.023                                                                             19.212                                                                             -19.942                                                                            1.00                                                                              21.20                                        ATOM  4186                                                                              CA  VAL                                                                               582                                                                               44.601                                                                             20.274                                                                             -19.151                                                                            1.00                                                                              24.84                                        ATOM  4187                                                                              CB  VAL                                                                               582                                                                               45.280                                                                             19.739                                                                             -17.894                                                                            1.00                                                                              27.84                                        ATOM  4188                                                                              CG1 VAL                                                                               582                                                                               45.931                                                                             20.889                                                                             -17.126                                                                            1.00                                                                              26.34                                        ATOM  4189                                                                              CG2 VAL                                                                               582                                                                               44.247                                                                             18.998                                                                             -17.019                                                                            1.00                                                                              30.24                                        ATOM  4190                                                                              C   VAL                                                                               582                                                                               45.579                                                                             20.970                                                                             -20.079                                                                            1.00                                                                              25.68                                        ATOM  4191                                                                              O   VAL                                                                               582                                                                               46.323                                                                             20.322                                                                             -20.792                                                                            1.00                                                                              23.96                                        ATOM  4192                                                                              N   GLN                                                                               583                                                                               45.499                                                                             22.291                                                                             -20.129                                                                            1.00                                                                              31.11                                        ATOM  4193                                                                              CA  GLN                                                                               583                                                                               46.341                                                                             23.103                                                                             -20.995                                                                            1.00                                                                              30.37                                        ATOM  4194                                                                              CB  GLN                                                                               583                                                                               45.485                                                                             23.732                                                                             -22.078                                                                            1.00                                                                              37.03                                        ATOM  4195                                                                              CG  GLN                                                                               583                                                                               44.573                                                                             22.758                                                                             -22.772                                                                            1.00                                                                              46.47                                        ATOM  4196                                                                              CD  GLN                                                                               583                                                                               43.483                                                                             23.449                                                                             -23.566                                                                            1.00                                                                              49.92                                        ATOM  4197                                                                              OE1 GLN                                                                               583                                                                               42.307                                                                             23.070                                                                             -23.475                                                                            1.00                                                                              54.21                                        ATOM  4198                                                                              NE2 GLN                                                                               583                                                                               43.856                                                                             24.471                                                                             -24.340                                                                            1.00                                                                              43.85                                        ATOM  4199                                                                              C   GLN                                                                               583                                                                               46.903                                                                             24.236                                                                             -20.188                                                                            1.00                                                                              27.68                                        ATOM  4200                                                                              O   GLN                                                                               583                                                                               46.271                                                                             24.679                                                                             -19.247                                                                            1.00                                                                              27.53                                        ATOM  4201                                                                              N   ASN                                                                               584                                                                               48.074                                                                             24.722                                                                             -20.565                                                                            1.00                                                                              25.21                                        ATOM  4202                                                                              CA  ASN                                                                               584                                                                               48.667                                                                             25.839                                                                             -19.862                                                                            1.00                                                                              25.95                                        ATOM  4203                                                                              CB  ASN                                                                               584                                                                               49.861                                                                             25.395                                                                             -19.017                                                                            1.00                                                                              27.68                                        ATOM  4204                                                                              CG  ASN                                                                               584                                                                               51.060                                                                             25.037                                                                             -19.837                                                                            1.00                                                                              24.49                                        ATOM  4205                                                                              OD1 ASN                                                                               584                                                                               50.977                                                                             24.927                                                                             -21.044                                                                            1.00                                                                              28.26                                        ATOM  4206                                                                              ND2 ASN                                                                               584                                                                               52.197                                                                             24.858                                                                             -19.181                                                                            1.00                                                                              25.26                                        ATOM  4207                                                                              C   ASN                                                                               584                                                                               49.059                                                                             26.829                                                                             -20.945                                                                            1.00                                                                              28.49                                        ATOM  4208                                                                              O   ASN                                                                               584                                                                               48.928                                                                             26.500                                                                             -22.129                                                                            1.00                                                                              29.88                                        ATOM  4209                                                                              N   SER                                                                               585                                                                               49.496                                                                             28.036                                                                             -20.579                                                                            1.00                                                                              27.45                                        ATOM  4210                                                                              CA  SER                                                                               585                                                                               49.875                                                                             29.035                                                                             -21 596                                                                            1.00                                                                              30.77                                        ATOM  4211                                                                              CB  SER                                                                               585                                                                               49.765                                                                             30.456                                                                             -21.039                                                                            1.00                                                                              29.03                                        ATOM  4212                                                                              OG  SER                                                                               585                                                                               50.325                                                                             30.548                                                                             -19.741                                                                            1.00                                                                              34.88                                        ATOM  4213                                                                              C   SER                                                                               585                                                                               51.253                                                                             28.811                                                                             -22.246                                                                            1.00                                                                              34.38                                        ATOM  4214                                                                              O   SER                                                                               585                                                                               51.708                                                                             29.622                                                                             -23.057                                                                            1.00                                                                              31.24                                        ATOM  4215                                                                              N   ASN                                                                               586                                                                               51.899                                                                             27.703                                                                             -21.867                                                                            1.00                                                                              37.42                                        ATOM  4216                                                                              CA  ASN                                                                               586                                                                               53.203                                                                             27.294                                                                             -22.371                                                                            1.00                                                                              35.38                                        ATOM  4217                                                                              CB  ASN                                                                               586                                                                               53.971                                                                             26.624                                                                             -21.236                                                                            1.00                                                                              41.48                                        ATOM  4218                                                                              CG  ASN                                                                               586                                                                               55.458                                                                             26.554                                                                             -21.491                                                                            1.00                                                                              47.03                                        ATOM  4219                                                                              OD1 ASN                                                                               586                                                                               56.116                                                                             25.553                                                                             -21.166                                                                            1.00                                                                              53.23                                        ATOM  4220                                                                              ND2 ASN                                                                               586                                                                               56.012                                                                             27.626                                                                             -22.041                                                                            1.00                                                                              48.92                                        ATOM  4221                                                                              C   ASN                                                                               586                                                                               52.915                                                                             26.292                                                                             -23.494                                                                            1.00                                                                              37.30                                        ATOM  4222                                                                              O   ASN                                                                               586                                                                               53.795                                                                             25.601                                                                             -23.990                                                                            1.00                                                                              40.09                                        ATOM  4223                                                                              N   ASN                                                                               587                                                                               51.641                                                                             26.196                                                                             -23.852                                                                            1.00                                                                              37.02                                        ATOM  4224                                                                              CA  ASN                                                                               587                                                                               51.159                                                                             25.321                                                                             -24.903                                                                            1.00                                                                              36.39                                        ATOM  4225                                                                              CB  ASN                                                                               587                                                                               51.752                                                                             25.738                                                                             -26.243                                                                            1.00                                                                              39.55                                        ATOM  4226                                                                              CG  ASN                                                                               587                                                                               51.245                                                                             27.096                                                                             -26.691                                                                            1.00                                                                              44.89                                        ATOM  4227                                                                              OD1 ASN                                                                               587                                                                               50.047                                                                             27.283                                                                             -26.893                                                                            1.00                                                                              46.33                                        ATOM  4228                                                                              ND2 ASN                                                                               587                                                                               52.148                                                                             28.064                                                                             -26.807                                                                            1.00                                                                              48.96                                        ATOM  4229                                                                              C   ASN                                                                               587                                                                               51.285                                                                             23.826                                                                             -24.668                                                                            1.00                                                                              35.84                                        ATOM  4230                                                                              O   ASN                                                                               587                                                                               51.377                                                                             23.051                                                                             -25.616                                                                            1.00                                                                              37.37                                        ATOM  4231                                                                              N   ASP                                                                               588                                                                               51.315                                                                             23.415                                                                             -23.405                                                                            1.00                                                                              32.62                                        ATOM  4232                                                                              CA  ASP                                                                               588                                                                               51.367                                                                             21.994                                                                             -23.085                                                                            1.00                                                                              27.76                                        ATOM  4233                                                                              CB  ASP                                                                               588                                                                               51.890                                                                             21.743                                                                             -21.662                                                                            1.00                                                                              27.66                                        ATOM  4234                                                                              CG  ASP                                                                               588                                                                               53.360                                                                             22.117                                                                             -21.482                                                                            1.00                                                                              32.14                                        ATOM  4235                                                                              OD1 ASP                                                                               588                                                                               54.196                                                                             21.764                                                                             -22.342                                                                            1.00                                                                              34.35                                        ATOM  4236                                                                              OD2 ASP                                                                               588                                                                               53.689                                                                             22.743                                                                             -20.448                                                                            1.00                                                                              37.89                                        ATOM  4237                                                                              C   ASP                                                                               588                                                                               49.898                                                                             21.604                                                                             -23.153                                                                            1.00                                                                              24.16                                        ATOM  4238                                                                              O   ASP                                                                               588                                                                               49.042                                                                             22.424                                                                             -22.859                                                                            1.00                                                                              29.81                                        ATOM  4239                                                                              N   PHE                                                                               589                                                                               49.601                                                                             20.378                                                                             -23.561                                                                            1.00                                                                              22.69                                        ATOM  4240                                                                              CA  PHE                                                                               589                                                                               48.233                                                                             19.911                                                                             -23.653                                                                            1.00                                                                              19.26                                        ATOM  4241                                                                              CB  PHE                                                                               589                                                                               47.781                                                                             19.909                                                                             -25.115                                                                            1.00                                                                              19.07                                        ATOM  4242                                                                              CG  PHE                                                                               589                                                                               46.329                                                                             19.561                                                                             -25.308                                                                            1.00                                                                              17.33                                        ATOM  4243                                                                              CD1 PHE                                                                               589                                                                               45.382                                                                             20.555                                                                             -25.464                                                                            1.00                                                                              13.39                                        ATOM  4244                                                                              CD2 PHE                                                                               589                                                                               45.913                                                                             18.242                                                                             -25.294                                                                            1.00                                                                              14.50                                        ATOM  4245                                                                              CE1 PHE                                                                               589                                                                               44.041                                                                             20.230                                                                             -25.595                                                                            1.00                                                                              14.12                                        ATOM  4246                                                                              CE2 PHE                                                                               589                                                                               44.581                                                                             17.923                                                                             -25.426                                                                            1.00                                                                              16.69                                        ATOM  4247                                                                              CZ  PHE                                                                               589                                                                               43.645                                                                             18.923                                                                             -25.576                                                                            1.00                                                                              13.30                                        ATOM  4248                                                                              C   PHE                                                                               589                                                                               48.277                                                                             18.496                                                                             -23.113                                                                            1.00                                                                              24.44                                        ATOM  4249                                                                              O   PHE                                                                               589                                                                               48.926                                                                             17.640                                                                             -23.703                                                                            1.00                                                                              27.71                                        ATOM  4250                                                                              N   LEU                                                                               590                                                                               47.610                                                                             18.239                                                                             -21.991                                                                            1.00                                                                              26.31                                        ATOM  4251                                                                              CA  LEU                                                                               590                                                                               47.632                                                                             16.907                                                                             -21.393                                                                            1.00                                                                              24.82                                        ATOM  4252                                                                              CB  LEU                                                                               590                                                                               48.088                                                                             16.974                                                                             -19.927                                                                            1.00                                                                              31.03                                        ATOM  4253                                                                              CG  LEU                                                                               590                                                                               49.371                                                                             17.763                                                                             -19.647                                                                            1.00                                                                              34.58                                        ATOM  4254                                                                              CD1 LEU                                                                               590                                                                               49.688                                                                             17.755                                                                             -18.166                                                                            1.00                                                                              39.41                                        ATOM  4255                                                                              CD2 LEU                                                                               590                                                                               50.529                                                                             17.193                                                                             -20.440                                                                            1.00                                                                              40.80                                        ATOM  4256                                                                              C   LEU                                                                               590                                                                               46.264                                                                             16.285                                                                             -21.475                                                                            1.00                                                                              22.29                                        ATOM  4257                                                                              O   LEU                                                                               590                                                                               45.268                                                                             16.965                                                                             -21.365                                                                            1.00                                                                              24.04                                        ATOM  4258                                                                              N   VAL                                                                               591                                                                               46.220                                                                             14.983                                                                             -21.670                                                                            1.00                                                                              21.66                                        ATOM  4259                                                                              CA  VAL                                                                               591                                                                               44.955                                                                             14.302                                                                             -21.773                                                                            1.00                                                                              24.60                                        ATOM  4260                                                                              CB  VAL                                                                               591                                                                               44.860                                                                             13.505                                                                             -23.076                                                                            1.00                                                                              25.35                                        ATOM  4261                                                                              CG1 VAL                                                                               591                                                                               43.700                                                                             12.514                                                                             -23.01                                                                             1.00                                                                              25.77                                        ATOM  4262                                                                              CG2 VAL                                                                               591                                                                               44.694                                                                             14.474                                                                             -24.248                                                                            1.00                                                                              25.42                                        ATOM  4263                                                                              C   VAL                                                                               591                                                                               44.873                                                                             13.383                                                                             -20.599                                                                            1.00                                                                              29.13                                        ATOM  4264                                                                              O   VAL                                                                               591                                                                               45.784                                                                             12.564                                                                             -20.389                                                                            1.00                                                                              34.66                                        ATOM  4265                                                                              N   ILE                                                                               592                                                                               43.773                                                                             13.510                                                                             -19.851                                                                            1.00                                                                              29.73                                        ATOM  4266                                                                              CA  ILE                                                                               592                                                                               43.530                                                                             12.726                                                                             -18.640                                                                            1.00                                                                              23.90                                        ATOM  4267                                                                              CB  ILE                                                                               592                                                                               43.552                                                                             13.666                                                                             -17.407                                                                            1.00                                                                              21.74                                        ATOM  4268                                                                              CG2 ILE                                                                               592                                                                               43.189                                                                             12.927                                                                             -16.148                                                                            1.00                                                                              16.67                                        ATOM  4269                                                                              CG1 ILE                                                                               592                                                                               44.940                                                                             14.319                                                                             -17.319                                                                            1.00                                                                              19.32                                        ATOM  4270                                                                              CD1 ILE                                                                               592                                                                               45.293                                                                             14.941                                                                             -15.995                                                                            1.00                                                                              24.87                                        ATOM  4271                                                                              C   ILE                                                                               592                                                                               42.245                                                                             11.903                                                                             -18.715                                                                            1.00                                                                              21.42                                        ATOM  4272                                                                              O   ILE                                                                               592                                                                               41.171                                                                             12.448                                                                             -18.843                                                                            1.00                                                                              19.52                                        ATOM  4273                                                                              N   TYR                                                                               593                                                                               42.380                                                                             10.580                                                                             -18.684                                                                            1.00                                                                              22.86                                        ATOM  4274                                                                              CA  TYR                                                                               593                                                                               41.242                                                                             9.680                                                                              -18.751                                                                            1.00                                                                              26.10                                        ATOM  4275                                                                              CB  TYR                                                                               593                                                                               41.630                                                                             8.313                                                                              -19.346                                                                            1.00                                                                              34.27                                        ATOM  4276                                                                              CG  TYR                                                                               593                                                                               42.224                                                                             8.392                                                                              -20.722                                                                            1.00                                                                              43.75                                        ATOM  4277                                                                              CD1 TYR                                                                               593                                                                               43.577                                                                             8.706                                                                              -20.903                                                                            1.00                                                                              47.60                                        ATOM  4278                                                                              CE1 TYR                                                                               593                                                                               44.120                                                                             8.903                                                                              -22.183                                                                            1.00                                                                              51.15                                        ATOM  4279                                                                              CD2 TYR                                                                               593                                                                               41.419                                                                             8.257                                                                              -21.854                                                                            1.00                                                                              51.36                                        ATOM  4280                                                                              CE2 TYR                                                                               593                                                                               41.951                                                                             8.450                                                                              -23.147                                                                            1.00                                                                              54.75                                        ATOM  4281                                                                              CZ  TYR                                                                               593                                                                               43.300                                                                             8.780                                                                              -23.301                                                                            1.00                                                                              56.25                                        ATOM  4282                                                                              OH  TYR                                                                               593                                                                               43.805                                                                             9.043                                                                              -24.569                                                                            1.00                                                                              63.62                                        ATOM  4283                                                                              C   TYR                                                                               593                                                                               40.806                                                                             9.431                                                                              -17.344                                                                            1.00                                                                              27.01                                        ATOM  4284                                                                              O   TYR                                                                               593                                                                               41.552                                                                             8.843                                                                              -16.581                                                                            1.00                                                                              30.49                                        ATOM  4285                                                                              N   ILE                                                                               594                                                                               39.633                                                                             9.918                                                                              -16.971                                                                            1.00                                                                              28.13                                        ATOM  4286                                                                              CA  ILE                                                                               594                                                                               39.126                                                                             9.668                                                                              -15.640                                                                            1.00                                                                              24.97                                        ATOM  4287                                                                              CB  ILE                                                                               594                                                                               38.397                                                                             10.914                                                                             -15.060                                                                            1.00                                                                              26.87                                        ATOM  4288                                                                              CG2 ILE                                                                               594                                                                               39.366                                                                             12.111                                                                             -15.052                                                                            1.00                                                                              24.59                                        ATOM  4289                                                                              CG1 ILE                                                                               594                                                                               37.127                                                                             11.250                                                                             -15.855                                                                            1.00                                                                              25.95                                        ATOM  4290                                                                              CD1 ILE                                                                               594                                                                               36.068                                                                             12.055                                                                             -15.092                                                                            1.00                                                                              20.64                                        ATOM  4291                                                                              C   ILE                                                                               594                                                                               38.236                                                                             8.425                                                                              -15.778                                                                            1.00                                                                              26.39                                        ATOM  4292                                                                              O   ILE                                                                               594                                                                               37.811                                                                             8.087                                                                              -16.886                                                                            1.00                                                                              29.00                                        ATOM  4293                                                                              N   ASN                                                                               595                                                                               38.083                                                                             7.658                                                                              -14.703                                                                            1.00                                                                              28.31                                        ATOM  4294                                                                              CA  ASN                                                                               595                                                                               37.256                                                                             6.446                                                                              -14.731                                                                            1.00                                                                              27.72                                        ATOM  4295                                                                              CB  ASN                                                                               595                                                                               38.030                                                                             5.188                                                                              -14.310                                                                            1.00                                                                              30.83                                        ATOM  4296                                                                              CG  ASN                                                                               595                                                                               39.106                                                                             4.793                                                                              -15.305                                                                            1.00                                                                              32.89                                        ATOM  4297                                                                              OD1 ASN                                                                               595                                                                               40.238                                                                             5.267                                                                              -15.224                                                                            1.00                                                                              36.90                                        ATOM  4298                                                                              ND2 ASN                                                                               595                                                                               38.770                                                                             3.900                                                                              -16.225                                                                            1.00                                                                              33.97                                        ATOM  4299                                                                              C   ASN                                                                               595                                                                               36.075                                                                             6.583                                                                              -13.807                                                                            1.00                                                                              28.15                                        ATOM  4300                                                                              O   ASN                                                                               595                                                                               36.057                                                                             7.435                                                                              -12.909                                                                            1.00                                                                              27.50                                        ATOM  4301                                                                              N   LYS                                                                               596                                                                               35.107                                                                             5.701                                                                              -14.021                                                                            1.00                                                                              27.21                                        ATOM  4302                                                                              CA  LYS                                                                               596                                                                               33.883                                                                             5.672                                                                              -13.244                                                                            1.00                                                                              25.84                                        ATOM  4303                                                                              CB  LYS                                                                               596                                                                               32.955                                                                             4.603                                                                              -13.805                                                                            1.00                                                                              24.28                                        ATOM  4304                                                                              CG  LYS                                                                               596                                                                               31.686                                                                             4.499                                                                              -13.047                                                                            1.00                                                                              24.79                                        ATOM  4305                                                                              CD  LYS                                                                               596                                                                               30.841                                                                             3.335                                                                              -13.480                                                                            1.00                                                                              28.00                                        ATOM  4306                                                                              CE  LYS                                                                               596                                                                               29.412                                                                             3.630                                                                              -13.058                                                                            1.00                                                                              28.21                                        ATOM  4307                                                                              NZ  LYS                                                                               596                                                                               28.558                                                                             2.421                                                                              -13.029                                                                            1.00                                                                              39.48                                        ATOM  4308                                                                              C   LYS                                                                               596                                                                               34.231                                                                             5.304                                                                              -11.819                                                                            1.00                                                                              26.80                                        ATOM  4309                                                                              O   LYS                                                                               596                                                                               34.908                                                                             4.308                                                                              -11.599                                                                            1.00                                                                              33.76                                        ATOM  4310                                                                              N   THR                                                                               597                                                                               33.764                                                                             6.075                                                                              -10.848                                                                            1.00                                                                              23.21                                        ATOM  4311                                                                              CA  THR                                                                               597                                                                               34.057                                                                             5.755                                                                              -9.465                                                                             1.00                                                                              19.85                                        ATOM  4312                                                                              CB  THR                                                                               597                                                                               34.832                                                                             6.899                                                                              -8.789                                                                             1.00                                                                              17.47                                        ATOM  4313                                                                              OG1 THR                                                                               597                                                                               34.170                                                                             8.134                                                                              -9.045                                                                             1.00                                                                              23.13                                        ATOM  4314                                                                              CG2 THR                                                                               597                                                                               36.252                                                                             7.008                                                                              -9.346                                                                             1.00                                                                              20.56                                        ATOM  4315                                                                              C   THR                                                                               597                                                                               32.796                                                                             5.445                                                                              -8.660                                                                             1.00                                                                              23.42                                        ATOM  4316                                                                              O   THR                                                                               597                                                                               32.881                                                                             4.846                                                                              -7.583                                                                             1.00                                                                              25.02                                        ATOM  4317                                                                              N   MET                                                                               598                                                                               31.626                                                                             5.762                                                                              -9.217                                                                             1.00                                                                              24.63                                        ATOM  4318                                                                              CA  MET                                                                               598                                                                               30.350                                                                             5.574                                                                              -8.508                                                                             1.00                                                                              29.69                                        ATOM  4319                                                                              CB  MET                                                                               598                                                                               30.064                                                                             6.832                                                                              -7.678                                                                             1.00                                                                              31.74                                        ATOM  4320                                                                              CG  MET                                                                               598                                                                               30.027                                                                             8.092                                                                              -8.549                                                                             1.00                                                                              36.11                                        ATOM  4321                                                                              SD  MET                                                                               598                                                                               29.755                                                                             9.702                                                                              -7.775                                                                             1.00                                                                              37.36                                        ATOM  4322                                                                              CE  MET                                                                               598                                                                               27.948                                                                             9.542                                                                              -7.233                                                                             1.00                                                                              43.52                                        ATOM  4323                                                                              C   MET                                                                               598                                                                               29.201                                                                             5.415                                                                              -9.479                                                                             1.00                                                                              28.31                                        ATOM  4324                                                                              O   MET                                                                               598                                                                               29.351                                                                             5.702                                                                              -10.642                                                                            1.00                                                                              36.08                                        ATOM  4325                                                                              N   ASN                                                                               599                                                                               28.046                                                                             4.978                                                                              -9.015                                                                             1.00                                                                              29.59                                        ATOM  4326                                                                              CA  ASN                                                                               599                                                                               26.909                                                                             4.878                                                                              -9.914                                                                             1.00                                                                              34.34                                        ATOM  4327                                                                              CB  ASN                                                                               599                                                                               26.040                                                                             3.662                                                                              -9.612                                                                             1.00                                                                              36.17                                        ATOM  4328                                                                              CG  ASN                                                                               599                                                                               26.744                                                                             2.360                                                                              -9.880                                                                             1.00                                                                              37.88                                        ATOM  4329                                                                              OD1 ASN                                                                               599                                                                               27.835                                                                             2.326                                                                              -10.422                                                                            1.00                                                                              44.96                                        ATOM  4330                                                                              ND2 ASN                                                                               599                                                                               26.124                                                                             1.271                                                                              -9.484                                                                             1.00                                                                              46.10                                        ATOM  4331                                                                              C   ASN                                                                               599                                                                               26.129                                                                             6.147                                                                              -9.654                                                                             1.00                                                                              38.09                                        ATOM  4332                                                                              O   ASN                                                                               599                                                                               26.335                                                                             6.794                                                                              -8.638                                                                             1.00                                                                              42.60                                        ATOM  4333                                                                              N   LYS                                                                               600                                                                               25.187                                                                             6.470                                                                              -10.525                                                                            1.00                                                                              43.32                                        ATOM  4334                                                                              CA  LYS                                                                               600                                                                               24.405                                                                             7.696                                                                              -10.380                                                                            1.00                                                                              46.30                                        ATOM  4335                                                                              CB  LYS                                                                               600                                                                               23.445                                                                             7.836                                                                              -11.562                                                                            1.00                                                                              52.15                                        ATOM  4336                                                                              CG  LYS                                                                               600                                                                               24.108                                                                             7.719                                                                              -12.922                                                                            1.00                                                                              58.49                                        ATOM  4337                                                                              CD  LYS                                                                               600                                                                               23.111                                                                             7.956                                                                              -14.047                                                                            1.00                                                                              64.43                                        ATOM  4338                                                                              CE  LYS                                                                               600                                                                               23.755                                                                             7.665                                                                              -15.395                                                                            1.00                                                                              69.24                                        ATOM  4339                                                                              NZ  LYS                                                                               600                                                                               22.804                                                                             7.771                                                                              -16.540                                                                            1.00                                                                              75.49                                        ATOM  4340                                                                              C   LYS                                                                               600                                                                               23.622                                                                             7.799                                                                              -9.077                                                                             1.00                                                                              46.95                                        ATOM  4341                                                                              O   LYS                                                                               600                                                                               23.478                                                                             8.882                                                                              -8.502                                                                             1.00                                                                              46.03                                        ATOM  4342                                                                              N   ASP                                                                               601                                                                               23.092                                                                             6.662                                                                              -8.642                                                                             1.00                                                                              49.46                                        ATOM  4343                                                                              CA  ASP                                                                               601                                                                               22.289                                                                             6.577                                                                              -7.425                                                                             1.00                                                                              49.50                                        ATOM  4344                                                                              CB  ASP                                                                               601                                                                               21.352                                                                             5.366                                                                              -7.507                                                                             1.00                                                                              50.83                                        ATOM  4345                                                                              CG  ASP                                                                               601                                                                               22.079                                                                             4.065                                                                              -7.887                                                                             1.00                                                                              55.52                                        ATOM  4346                                                                              OD1 ASP                                                                               601                                                                               21.381                                                                             3.044                                                                              -8.093                                                                             1.00                                                                              57.44                                        ATOM  4347                                                                              OD2 ASP                                                                               601                                                                               23.330                                                                             4.050                                                                              -7.985                                                                             1.00                                                                              53.34                                        ATOM  4348                                                                              C   ASP                                                                               601                                                                               23.130                                                                             6.516                                                                              -6.152                                                                             1.00                                                                              50.82                                        ATOM  4349                                                                              O   ASP                                                                               601                                                                               22.613                                                                             6.263                                                                              -5.055                                                                             1.00                                                                              54.21                                        ATOM  4350                                                                              N   ASP                                                                               602                                                                               24.434                                                                             6.710                                                                              -6.302                                                                             1.00                                                                              48.64                                        ATOM  4351                                                                              CA  ASP                                                                               602                                                                               25.330                                                                             6.691                                                                              -5.159                                                                             1.00                                                                              44.01                                        ATOM  4352                                                                              CB  ASP                                                                               602                                                                               26.717                                                                             6.214                                                                              -5.575                                                                             1.00                                                                              40.23                                        ATOM  4353                                                                              CG  ASP                                                                               602                                                                               26.791                                                                             4.738                                                                              -5.737                                                                             1.00                                                                              37.25                                        ATOM  4354                                                                              OD1 ASP                                                                               602                                                                               27.816                                                                             4.259                                                                              -6.264                                                                             1.00                                                                              36.68                                        ATOM  4355                                                                              OD2 ASP                                                                               602                                                                               25.833                                                                             4.054                                                                              -5.321                                                                             1.00                                                                              42.23                                        ATOM  4356                                                                              C   ASP                                                                               602                                                                               25.467                                                                             8.073                                                                              -4.558                                                                             1.00                                                                              44.20                                        ATOM  4357                                                                              O   ASP                                                                               602                                                                               25.306                                                                             9.086                                                                              -5.248                                                                             1.00                                                                              45.97                                        ATOM  4358                                                                              N   ASP                                                                               603                                                                               25.764                                                                             8.107                                                                              -3.265                                                                             1.00                                                                              43.46                                        ATOM  4359                                                                              CA  ASP                                                                               603                                                                               25.978                                                                             9.361                                                                              -2.571                                                                             1.00                                                                              38.92                                        ATOM  4360                                                                              CB  ASP                                                                               603                                                                               25.448                                                                             9.294                                                                              -1.135                                                                             1.00                                                                              48.43                                        ATOM  4361                                                                              CG  ASP                                                                               603                                                                               23.964                                                                             9.623                                                                              -1.042                                                                             1.00                                                                              58.48                                        ATOM  4362                                                                              OD1 ASP                                                                               603                                                                               23.139                                                                             8.684                                                                              -1.123                                                                             1.00                                                                              62.56                                        ATOM  4363                                                                              OD2 ASP                                                                               603                                                                               23.626                                                                             10.824                                                                             -0.878                                                                             1.00                                                                              63.75                                        ATOM  4364                                                                              C   ASP                                                                               603                                                                               27.477                                                                             9.613                                                                              -2.573                                                                             1.00                                                                              31.62                                        ATOM  4365                                                                              O   ASP                                                                               603                                                                               28.274                                                                             8.688                                                                              -2.729                                                                             1.00                                                                              23.41                                        ATOM  4366                                                                              N   LEU                                                                               604                                                                               27.842                                                                             10.881                                                                             -2.448                                                                             1.00                                                                              28.74                                        ATOM  4367                                                                              CA  LEU                                                                               604                                                                               29.226                                                                             11.278                                                                             -2.422                                                                             1.00                                                                              27.24                                        ATOM  4368                                                                              CB  LEU                                                                               604                                                                               29.357                                                                             12.764                                                                             -2.664                                                                             1.00                                                                              22.42                                        ATOM  4369                                                                              CG  LEU                                                                               604                                                                               29.148                                                                             13.160                                                                             -4.095                                                                             1.00                                                                              19.01                                        ATOM  4370                                                                              CD1 LEU                                                                               604                                                                               29.691                                                                             14.557                                                                             -4.260                                                                             1.00                                                                              22.34                                        ATOM  4371                                                                              CD2 LEU                                                                               604                                                                               29.876                                                                             12.206                                                                             -4.987                                                                             1.00                                                                              23.64                                        ATOM  4372                                                                              C   LEU                                                                               604                                                                               29.915                                                                             10.933                                                                             -1.117                                                                             1.00                                                                              26.64                                        ATOM  4373                                                                              O   LEU                                                                               604                                                                               29.977                                                                             11.739                                                                             -0.206                                                                             1.00                                                                              30.89                                        ATOM  4374                                                                              N   THR                                                                               605                                                                               30.398                                                                             9.713                                                                              -1.020                                                                             1.00                                                                              27.07                                        ATOM  4375                                                                              CA  THR                                                                               605                                                                               31.118                                                                             9.302                                                                              0.160                                                                              1.00                                                                              27.67                                        ATOM  4376                                                                              CB  THR                                                                               605                                                                               30.660                                                                             7.934                                                                              0.637                                                                              1.00                                                                              26.78                                        ATOM  4377                                                                              OG1 THR                                                                               605                                                                               30.956                                                                             6.950                                                                              -0.361                                                                             1.00                                                                              35.48                                        ATOM  4378                                                                              CG2 THR                                                                               605                                                                               29.155                                                                             7.972                                                                              0.902                                                                              1.00                                                                              28.06                                        ATOM  4379                                                                              C   THR                                                                               605                                                                               32.613                                                                             9.291                                                                              -0.151                                                                             1.00                                                                              26.21                                        ATOM  4380                                                                              O   THR                                                                               605                                                                               33.032                                                                             9.490                                                                              -1.307                                                                             1.00                                                                              26.25                                        ATOM  4381                                                                              N   TYR                                                                               606                                                                               33.416                                                                             9.058                                                                              0.879                                                                              1.00                                                                              24.88                                        ATOM  4382                                                                              CA  TYR                                                                               606                                                                               34.852                                                                             9.038                                                                              0.722                                                                              1.00                                                                              21.81                                        ATOM  4383                                                                              CB  TYR                                                                               606                                                                               35.530                                                                             8.580                                                                              2.010                                                                              1.00                                                                              19.51                                        ATOM  4384                                                                              CG  TYR                                                                               606                                                                               37.025                                                                             8.692                                                                              1.931                                                                              1.00                                                                              19.63                                        ATOM  4385                                                                              CD1 TYR                                                                               606                                                                               37.659                                                                             9.942                                                                              2.019                                                                              1.00                                                                              19.75                                        ATOM  4386                                                                              CE1 TYR                                                                               606                                                                               39.032                                                                             10.068                                                                             1.821                                                                              1.00                                                                              17.57                                        ATOM  4387                                                                              CD2 TYR                                                                               606                                                                               37.806                                                                             7.566                                                                              1.655                                                                              1.00                                                                              16.29                                        ATOM  4388                                                                              CE2 TYR                                                                               606                                                                               39.176                                                                             7.674                                                                              1.457                                                                              1.00                                                                              16.64                                        ATOM  4389                                                                              CZ  TYR                                                                               606                                                                               39.782                                                                             8.923                                                                              1.544                                                                              1.00                                                                              18.29                                        ATOM  4390                                                                              OH  TYR                                                                               606                                                                               41.144                                                                             9.001                                                                              1.411                                                                              1.00                                                                              23.20                                        ATOM  4391                                                                              C   TYR                                                                               606                                                                               35.281                                                                             8.184                                                                              -0.471                                                                             1.00                                                                              23.40                                        ATOM  4392                                                                              O   TYR                                                                               606                                                                               35.921                                                                             8.691                                                                              -1.389                                                                             1.00                                                                              22.13                                        ATOM  4393                                                                              N   GLN                                                                               607                                                                               34.870                                                                             6.924                                                                              -0.509                                                                             1.00                                                                              27.60                                        ATOM  4394                                                                              CA  GLN                                                                               607                                                                               35.250                                                                             6.036                                                                              -1.607                                                                             1.00                                                                              29.41                                        ATOM  4395                                                                              CB  GLN                                                                               607                                                                               34.811                                                                             4.594                                                                              -1.320                                                                             1.00                                                                              37.18                                        ATOM  4396                                                                              CG  GLN                                                                               607                                                                               33.310                                                                             4.398                                                                              -1.147                                                                             1.00                                                                              50.31                                        ATOM  4397                                                                              CD  GLN                                                                               607                                                                               32.949                                                                             2.961                                                                              -0.777                                                                             1.00                                                                              59.10                                        ATOM  4398                                                                              OE1 GLN                                                                               607                                                                               33.005                                                                             2.048                                                                              -1.610                                                                             1.00                                                                              66.18                                        ATOM  4399                                                                              NE2 GLN                                                                               607                                                                               32.595                                                                             2.752                                                                              0.483                                                                              1.00                                                                              64.92                                        ATOM  4400                                                                              C   GLN                                                                               607                                                                               34.832                                                                             6.451                                                                              -3.027                                                                             1.00                                                                              29.69                                        ATOM  4401                                                                              O   GLN                                                                               607                                                                               35.347                                                                             5.892                                                                              -4.005                                                                             1.00                                                                              33.55                                        ATOM  4402                                                                              N   THR                                                                               608                                                                               33.935                                                                             7.430                                                                              -3.167                                                                             1.00                                                                              26.45                                        ATOM  4403                                                                              CA  THR                                                                               608                                                                               33.535                                                                             7.861                                                                              -4.512                                                                             1.00                                                                              22.19                                        ATOM  4404                                                                              CB  THR                                                                               608                                                                               32.188                                                                             8.600                                                                              -4.519                                                                             1.00                                                                              18.19                                        ATOM  4405                                                                              OG1 THR                                                                               608                                                                               32.268                                                                             9.728                                                                              -3.649                                                                             1.00                                                                              22.75                                        ATOM  4406                                                                              CG2 THR                                                                               608                                                                               31.052                                                                             7.685                                                                              -4.072                                                                             1.00                                                                              15.16                                        ATOM  4407                                                                              C   THR                                                                               608                                                                               34.596                                                                             8.751                                                                              -5.200                                                                             1.00                                                                              24.93                                        ATOM  4408                                                                              O   THR                                                                               608                                                                               34.521                                                                             8.982                                                                              -6.403                                                                             1.00                                                                              30.46                                        ATOM  4409                                                                              N   PHE                                                                               609                                                                               35.547                                                                             9.301                                                                              -4.450                                                                             1.00                                                                              20.11                                        ATOM  4410                                                                              CA  PHE                                                                               609                                                                               36.575                                                                             10.116                                                                             -5.073                                                                             1.00                                                                              17.66                                        ATOM  4411                                                                              CB  PHE                                                                               609                                                                               36.904                                                                             11.346                                                                             -4.251                                                                             1.00                                                                              16.23                                        ATOM  4412                                                                              CG  PHE                                                                               609                                                                               35.841                                                                             12.399                                                                             -4.296                                                                             1.00                                                                              15.72                                        ATOM  4413                                                                              CD1 PHE                                                                               609                                                                               34.710                                                                             12.290                                                                             -3.510                                                                             1.00                                                                              14.16                                        ATOM  4414                                                                              CD2 PHE                                                                               609                                                                               36.012                                                                             13.537                                                                             -5.062                                                                             1.00                                                                              19.17                                        ATOM  4415                                                                              CE1 PHE                                                                               609                                                                               33.785                                                                             13.285                                                                             -3.467                                                                             1.00                                                                              13.99                                        ATOM  4416                                                                              CE2 PHE                                                                               609                                                                               35.080                                                                             14.554                                                                             -5.031                                                                             1.00                                                                              17.80                                        ATOM  4417                                                                              CZ  PHE                                                                               609                                                                               33.965                                                                             14.430                                                                             -4.226                                                                             1.00                                                                              19.15                                        ATOM  4418                                                                              C   PHE                                                                               609                                                                               37.822                                                                             9.306                                                                              -5.368                                                                             1.00                                                                              17.82                                        ATOM  4419                                                                              O   PHE                                                                               609                                                                               38.097                                                                             8.300                                                                              -4.704                                                                             1.00                                                                              18.54                                        ATOM  4420                                                                              N   ASP                                                                               610                                                                               38.589                                                                             9.760                                                                              -6.354                                                                             1.00                                                                              16.24                                        ATOM  4421                                                                              CA  ASP                                                                               610                                                                               39.774                                                                             9.048                                                                              -6.783                                                                             1.00                                                                              17.82                                        ATOM  4422                                                                              CB  ASP                                                                               610                                                                               39.332                                                                             7.956                                                                              -7.763                                                                             1.00                                                                              28.02                                        ATOM  4423                                                                              CG  ASP                                                                               610                                                                               40.381                                                                             6.868                                                                              -7.980                                                                             1.00                                                                              30.47                                        ATOM  4424                                                                              OD1 ASP                                                                               610                                                                               40.134                                                                             5.962                                                                              -8.812                                                                             1.00                                                                              36.74                                        ATOM  4425                                                                              OD2 ASP                                                                               610                                                                               41.442                                                                             6.910                                                                              -7.330                                                                             1.00                                                                              35.21                                        ATOM  4426                                                                              C   ASP                                                                               610                                                                               40.746                                                                             10.006                                                                             -7.437                                                                             1.00                                                                              15.64                                        ATOM  4427                                                                              O   ASP                                                                               610                                                                               40.479                                                                             11.198                                                                             -7.502                                                                             1.00                                                                              18.05                                        ATOM  4428                                                                              N   LEU                                                                               611                                                                               41.888                                                                             9.489                                                                              -7.888                                                                             1.00                                                                              19.89                                        ATOM  4429                                                                              CA  LEU                                                                               611                                                                               42.934                                                                             10.287                                                                             -8.539                                                                             1.00                                                                              22.31                                        ATOM  4430                                                                              CB  LEU                                                                               611                                                                               44.226                                                                             10.295                                                                             -7.718                                                                             1.00                                                                              18.56                                        ATOM  4431                                                                              CG  LEU                                                                               611                                                                               44.209                                                                             10.950                                                                             -6.347                                                                             1.00                                                                              20.61                                        ATOM  4432                                                                              CD1 LEU                                                                               611                                                                               45.472                                                                             10.479                                                                             -5.583                                                                             1.00                                                                              22.97                                        ATOM  4433                                                                              CD2 LEU                                                                               611                                                                               44.143                                                                             12.474                                                                             -6.485                                                                             1.00                                                                              16.32                                        ATOM  4434                                                                              C   LEU                                                                               611                                                                               43.289                                                                             9.779                                                                              -9.923                                                                             1.00                                                                              24.26                                        ATOM  4435                                                                              O   LEU                                                                               611                                                                               43.798                                                                             8.672                                                                              -10.070                                                                            1.00                                                                              28.19                                        ATOM  4436                                                                              N   ALA                                                                               612                                                                               43.054                                                                             10.620                                                                             -10.922                                                                            1.00                                                                              26.15                                        ATOM  4437                                                                              CA  ALA                                                                               612                                                                               43.367                                                                             10.303                                                                             -12.297                                                                            1.00                                                                              25.40                                        ATOM  4438                                                                              CB  ALA                                                                               612                                                                               42.212                                                                             10.717                                                                             -13.206                                                                            1.00                                                                              18.53                                        ATOM  4439                                                                              C   ALA                                                                               612                                                                               44.604                                                                             11.145                                                                             -12.583                                                                            1.00                                                                              26.87                                        ATOM  4440                                                                              O   ALA                                                                               612                                                                               44.722                                                                             12.255                                                                             -12.073                                                                            1.00                                                                              29.03                                        ATOM  4441                                                                              N   THR                                                                               613                                                                               45.563                                                                             10.589                                                                             -13.316                                                                            1.00                                                                              30.85                                        ATOM  4442                                                                              CA  THR                                                                               613                                                                               46.790                                                                             11.306                                                                             -13.677                                                                            1.00                                                                              30.80                                        ATOM  4443                                                                              CB  THR                                                                               613                                                                               47.954                                                                             11.021                                                                             -12.682                                                                            1.00                                                                              31.03                                        ATOM  4444                                                                              OG1 THR                                                                               613                                                                               49.138                                                                             11.733                                                                             -13.085                                                                            1.00                                                                              30.18                                        ATOM  4445                                                                              CG2 THR                                                                               613                                                                               48.230                                                                             9.526                                                                              -12.581                                                                            1.00                                                                              26.60                                        ATOM  4446                                                                              C   THR                                                                               613                                                                               47.203                                                                             10.922                                                                             -15.095                                                                            1.00                                                                              32.15                                        ATOM  4447                                                                              O   THR                                                                               613                                                                               46.509                                                                             10.148                                                                             -15.777                                                                            1.00                                                                              28.30                                        ATOM  4448                                                                              N   THR                                                                               614                                                                               48.293                                                                             11.511                                                                             -15.559                                                                            1.00                                                                              33.49                                        ATOM  4449                                                                              CA  THR                                                                               614                                                                               48.793                                                                             11.217                                                                             -16.885                                                                            1.00                                                                              37.88                                        ATOM  4450                                                                              CB  THR                                                                               614                                                                               48.422                                                                             12.345                                                                             -17.907                                                                            1.00                                                                              39.76                                        ATOM  4451                                                                              OG1 THR                                                                               614                                                                               48.954                                                                             12.044                                                                             -19.206                                                                            1.00                                                                              41.06                                        ATOM  4452                                                                              CG2 THR                                                                               614                                                                               48.905                                                                             13.698                                                                             -17.434                                                                            1.00                                                                              37.77                                        ATOM  4453                                                                              C   THR                                                                               614                                                                               50.285                                                                             11.049                                                                             -16.701                                                                            1.00                                                                              41.10                                        ATOM  4454                                                                              O   THR                                                                               614                                                                               50.842                                                                             11.420                                                                             -15.662                                                                            1.00                                                                              41.53                                        ATOM  4455                                                                              N   ASN                                                                               615                                                                               50.925                                                                             10.411                                                                             -17.662                                                                            1.00                                                                              45.48                                        ATOM  4456                                                                              CA  ASN                                                                               615                                                                               52.356                                                                             10.191                                                                             -17.563                                                                            1.00                                                                              50.76                                        ATOM  4457                                                                              CB  ASN                                                                               615                                                                               52.724                                                                             8.742                                                                              -17.888                                                                            1.00                                                                              56.94                                        ATOM  4458                                                                              CG  ASN                                                                               615                                                                               51.730                                                                             8.072                                                                              -18.820                                                                            1.00                                                                              64.66                                        ATOM  4459                                                                              OD1 ASN                                                                               615                                                                               50.839                                                                             8.714                                                                              -19.386                                                                            1.00                                                                              70.36                                        ATOM  4460                                                                              ND2 ASN                                                                               615                                                                               51.861                                                                             6.759                                                                              -18.964                                                                            1.00                                                                              69.92                                        ATOM  4461                                                                              C   ASN                                                                               615                                                                               53.157                                                                             11.179                                                                             -18.397                                                                            1.00                                                                              52.54                                        ATOM  4462                                                                              O   ASN                                                                               615                                                                               54.353                                                                             10.975                                                                             -18.645                                                                            1.00                                                                              58.56                                        ATOM  4463                                                                              N   SER                                                                               616                                                                               52.491                                                                             12.244                                                                             -18.838                                                                            1.00                                                                              47.84                                        ATOM  4464                                                                              CA  SER                                                                               616                                                                               53.146                                                                             13.299                                                                             -19.602                                                                            1.00                                                                              43.54                                        ATOM  4465                                                                              CB  SER                                                                               616                                                                               52.307                                                                             13.715                                                                             -20.805                                                                            1.00                                                                              43.84                                        ATOM  4466                                                                              G   SER                                                                               616                                                                               51.844                                                                             12.577                                                                             -21.512                                                                            1.00                                                                              54.32                                        ATOM  4467                                                                              C   SER                                                                               616                                                                               53.147                                                                             14.417                                                                             -18.589                                                                            1.00                                                                              40.19                                        ATOM  4468                                                                              O   SER                                                                               616                                                                               52.263                                                                             14.471                                                                             -17.742                                                                            1.00                                                                              42.93                                        ATOM  4469                                                                              N   ASN                                                                               617                                                                               54.150                                                                             15.273                                                                             -18.617                                                                            1.00                                                                              37.04                                        ATOM  4470                                                                              CA  ASN                                                                               617                                                                               54.177                                                                             16.358                                                                             -17.663                                                                            1.00                                                                              35.69                                        ATOM  4471                                                                              CB  ASN                                                                               617                                                                               55.374                                                                             16.225                                                                             -16.707                                                                            1.00                                                                              37.96                                        ATOM  4472                                                                              CG  ASN                                                                               617                                                                               56.672                                                                             15.997                                                                             -17.423                                                                            1.00                                                                              39.01                                        ATOM  4473                                                                              OD1 ASN                                                                               617                                                                               56.979                                                                             14.882                                                                             -17.808                                                                            1.00                                                                              43.35                                        ATOM  4474                                                                              ND2 ASN                                                                               617                                                                               57.455                                                                             17.044                                                                             -17.583                                                                            1.00                                                                              36.32                                        ATOM  4475                                                                              C   ASN                                                                               617                                                                               54.119                                                                             17.732                                                                             -18.325                                                                            1.00                                                                              34.05                                        ATOM  4476                                                                              O   ASN                                                                               617                                                                               54.092                                                                             17.853                                                                             -19.554                                                                            1.00                                                                              30.94                                        ATOM  4477                                                                              N   MET                                                                               618                                                                               54.030                                                                             18.767                                                                             -17.500                                                                            1.00                                                                              33.24                                        ATOM  4478                                                                              CA  MET                                                                               618                                                                               53.970                                                                             20.117                                                                             -18.013                                                                            1.00                                                                              33.10                                        ATOM  4479                                                                              CB  MET                                                                               618                                                                               52.520                                                                             20.636                                                                             -18.025                                                                            1.00                                                                              32.29                                        ATOM  4480                                                                              CG  MET                                                                               618                                                                               51.949                                                                             21.088                                                                             -16.702                                                                            1.00                                                                              29.92                                        ATOM  4481                                                                              SD  MET                                                                               618                                                                               50.249                                                                             21.651                                                                             -16.931                                                                            1.00                                                                              30.97                                        ATOM  4482                                                                              CE  MET                                                                               618                                                                               50.471                                                                             23.199                                                                             -16.787                                                                            1.00                                                                              32.23                                        ATOM  4483                                                                              C   MET                                                                               618                                                                               54.921                                                                             21.078                                                                             -17.297                                                                            1.00                                                                              31.41                                        ATOM  4484                                                                              O   MET                                                                               618                                                                               55.356                                                                             20.833                                                                             -16.165                                                                            1.00                                                                              31.17                                        ATOM  4485                                                                              N   GLY                                                                               619                                                                               55.309                                                                             22.120                                                                             -18.018                                                                            1.00                                                                              27.75                                        ATOM  4486                                                                              CA  GLY                                                                               619                                                                               56.210                                                                             23.112                                                                             -17.481                                                                            1.00                                                                              27.31                                        ATOM  4487                                                                              C   GLY                                                                               619                                                                               55.584                                                                             24.468                                                                             -17.688                                                                            1.00                                                                              27.73                                        ATOM  4488                                                                              O   GLY                                                                               619                                                                               54.616                                                                             24.605                                                                             -18.457                                                                            1.00                                                                              23.45                                        ATOM  4489                                                                              N   PHE                                                                               620                                                                               56.173                                                                             25.472                                                                             -17.046                                                                            1.00                                                                              32.05                                        ATOM  4490                                                                              CA  PHE                                                                               620                                                                               55.670                                                                             26.836                                                                             -17.087                                                                            1.00                                                                              34.44                                        ATOM  4491                                                                              CB  PHE                                                                               620                                                                               55.100                                                                             27.179                                                                             -15.715                                                                            1.00                                                                              33.94                                        ATOM  4492                                                                              CG  PHE                                                                               620                                                                               53.926                                                                             26.321                                                                             -15.312                                                                            1.00                                                                              28.19                                        ATOM  4493                                                                              CD1 PHE                                                                               620                                                                               54.124                                                                             25.157                                                                             -14.594                                                                            1.00                                                                              26.00                                        ATOM  4494                                                                              CD2 PHE                                                                               620                                                                               52.626                                                                             26.704                                                                             -15.632                                                                            1.00                                                                              28.04                                        ATOM  4495                                                                              CE1 PHE                                                                               620                                                                               53.063                                                                             24.389                                                                             -14.199                                                                            1.00                                                                              27.86                                        ATOM  4496                                                                              CE2 PHE                                                                               620                                                                               51.545                                                                             25.945                                                                             -15.237                                                                            1.00                                                                              24.13                                        ATOM  4497                                                                              CZ  PHE                                                                               620                                                                               51.762                                                                             24.786                                                                             -14.518                                                                            1.00                                                                              29.09                                        ATOM  4498                                                                              C   PHE                                                                               620                                                                               56.743                                                                             27.854                                                                             -17.445                                                                            1.00                                                                              40.11                                        ATOM  4499                                                                              O   PHE                                                                               620                                                                               57.936                                                                             27.577                                                                             -17.300                                                                            1.00                                                                              43.33                                        ATOM  4500                                                                              N   SER                                                                               621                                                                               56.317                                                                             29.042                                                                             -17.877                                                                            1.00                                                                              46.66                                        ATOM  4501                                                                              CA  SER                                                                               621                                                                               57.239                                                                             30.115                                                                             -18.269                                                                            1.00                                                                              53.27                                        ATOM  4502                                                                              CB  SER                                                                               621                                                                               57.435                                                                             30.146                                                                             -19.794                                                                            1.00                                                                              53.87                                        ATOM  4503                                                                              OG  SER                                                                               621                                                                               58.551                                                                             29.390                                                                             -20.252                                                                            1.00                                                                              59.49                                        ATOM  4504                                                                              C   SER                                                                               621                                                                               56.763                                                                             31.502                                                                             -17.826                                                                            1.00                                                                              56.51                                        ATOM  4505                                                                              O   SER                                                                               621                                                                               55.563                                                                             31.802                                                                             -17.846                                                                            1.00                                                                              56.27                                        ATOM  4506                                                                              N   GLY                                                                               622                                                                               57.720                                                                             32.347                                                                             -17.453                                                                            1.00                                                                              58.36                                        ATOM  4507                                                                              CA  GLY                                                                               622                                                                               57.412                                                                             33.705                                                                             -17.050                                                                            1.00                                                                              60.94                                        ATOM  4508                                                                              C   GLY                                                                               622                                                                               56.503                                                                             33.879                                                                             -15.858                                                                            1.00                                                                              62.66                                        ATOM  4509                                                                              O   GLY                                                                               622                                                                               56.282                                                                             32.946                                                                             -15.085                                                                            1.00                                                                              61.90                                        ATOM  4510                                                                              N   ASP                                                                               623                                                                               55.975                                                                             35.092                                                                             -15.723                                                                            1.00                                                                              66.16                                        ATOM  4511                                                                              CA  ASP                                                                               623                                                                               55.087                                                                             35.438                                                                             -14.618                                                                            1.00                                                                              70.95                                        ATOM  4512                                                                              CB  ASP                                                                               623                                                                               55.539                                                                             36.754                                                                             -13.940                                                                            1.00                                                                              73.92                                        ATOM  4513                                                                              CG  ASP                                                                               623                                                                               55.538                                                                             37.966                                                                             -14.885                                                                            1.00                                                                              79.61                                        ATOM  4514                                                                              OD1 ASP                                                                               623                                                                               55.879                                                                             37.814                                                                             -16.085                                                                            1.00                                                                              81.17                                        ATOM  4515                                                                              OD2 ASP                                                                               623                                                                               55.216                                                                             39.087                                                                             -14.406                                                                            1.00                                                                              81.72                                        ATOM  4516                                                                              C   ASP                                                                               623                                                                               53.583                                                                             35.457                                                                             -14.972                                                                            1.00                                                                              71.09                                        ATOM  4517                                                                              O   ASP                                                                               623                                                                               52.732                                                                             35.653                                                                             -14.091                                                                            1.00                                                                              71.06                                        ATOM  4518                                                                              N   LYS                                                                               624                                                                               53.260                                                                             35.226                                                                             -16.247                                                                            1.00                                                                              69.73                                        ATOM  4519                                                                              CA  LYS                                                                               624                                                                               51.864                                                                             35.193                                                                             -16.704                                                                            1.00                                                                              65.87                                        ATOM  4520                                                                              CB  LYS                                                                               624                                                                               51.632                                                                             36.207                                                                             -17.838                                                                            1.00                                                                              71.81                                        ATOM  4521                                                                              CG  LYS                                                                               624                                                                               52.482                                                                             35.977                                                                             -19.090                                                                            1.00                                                                              81.96                                        ATOM  4522                                                                              CD  LYS                                                                               624                                                                               52.057                                                                             36.892                                                                             -20.248                                                                            1.00                                                                              88.09                                        ATOM  4523                                                                              CE  LYS                                                                               624                                                                               52.741                                                                             36.515                                                                             -21.580                                                                            1.00                                                                              91.31                                        ATOM  4524                                                                              NZ  LYS                                                                               624                                                                               52.259                                                                             37.339                                                                             -22.749                                                                            1.00                                                                              90.55                                        ATOM  4525                                                                              C   LYS                                                                               624                                                                               51.448                                                                             33.764                                                                             -17.119                                                                            1.00                                                                              59.37                                        ATOM  4526                                                                              O   LYS                                                                               624                                                                               51.266                                                                             33.448                                                                             -18.302                                                                            1.00                                                                              58.24                                        ATOM  4527                                                                              N   ASN                                                                               625                                                                               51.314                                                                             32.906                                                                             -16.115                                                                            1.00                                                                              49.44                                        ATOM  4528                                                                              CA  ASN                                                                               625                                                                               50.948                                                                             31.519                                                                             -16.317                                                                            1.00                                                                              43.23                                        ATOM  4529                                                                              CB  ASN                                                                               625                                                                               51.789                                                                             30.642                                                                             -15.417                                                                            1.00                                                                              42.10                                        ATOM  4530                                                                              CG  ASN                                                                               625                                                                               53.236                                                                             30.661                                                                             -15.816                                                                            1.00                                                                              40.84                                        ATOM  4531                                                                              OD1 ASN                                                                               625                                                                               53.650                                                                             29.911                                                                             -16.696                                                                            1.00                                                                              43.01                                        ATOM  4532                                                                              ND2 ASN                                                                               625                                                                               54.009                                                                             31.556                                                                             -15.215                                                                            1.00                                                                              39.55                                        ATOM  4533                                                                              C   ASN                                                                               625                                                                               49.479                                                                             31.251                                                                             -16.093                                                                            1.00                                                                              39.80                                        ATOM  4534                                                                              O   ASN                                                                               625                                                                               48.923                                                                             31.608                                                                             -15.064                                                                            1.00                                                                              39.13                                        ATOM  4535                                                                              N   GLU                                                                               626                                                                               48.845                                                                             30.629                                                                             -17.075                                                                            1.00                                                                              36.93                                        ATOM  4536                                                                              CA  GLU                                                                               626                                                                               47.423                                                                             30.335                                                                             -16.993                                                                            1.00                                                                              38.81                                        ATOM  4537                                                                              CB  GLU                                                                               626                                                                               46.619                                                                             31.272                                                                             -17.915                                                                            1.00                                                                              43.39                                        ATOM  4538                                                                              CG  GLU                                                                               626                                                                               47.131                                                                             32.752                                                                             -17.888                                                                            1.00                                                                              54.84                                        ATOM  4539                                                                              CD  GLU                                                                               626                                                                               46.114                                                                             33.803                                                                             -17.389                                                                            1.00                                                                              56.51                                        ATOM  4540                                                                              OE1 GLU                                                                               626                                                                               44.916                                                                             33.718                                                                             -17.760                                                                            1.00                                                                              58.31                                        ATOM  4541                                                                              OE2 GLU                                                                               626                                                                               46.538                                                                             34.745                                                                             -16.664                                                                            1.00                                                                              56.35                                        ATOM  4542                                                                              C   GLU                                                                               626                                                                               47.183                                                                             28.865                                                                             -17.313                                                                            1.00                                                                              34.04                                        ATOM  4543                                                                              O   GLU                                                                               626                                                                               47.992                                                                             28.227                                                                             -17.991                                                                            1.00                                                                              28.90                                        ATOM  4544                                                                              N   LEU                                                                               627                                                                               46.117                                                                             28.322                                                                             -16.734                                                                            1.00                                                                              33.32                                        ATOM  4545                                                                              CA  LEU                                                                               627                                                                               45.757                                                                             26.925                                                                             -16.893                                                                            1.00                                                                              31.13                                        ATOM  4546                                                                              CB  LEU                                                                               627                                                                               46.061                                                                             26.154                                                                             -15.584                                                                            1.00                                                                              28.96                                        ATOM  4547                                                                              CG  LEU                                                                               627                                                                               46.022                                                                             24.613                                                                             -15.610                                                                            1.00                                                                              27.57                                        ATOM  4548                                                                              CD1 LEU                                                                               627                                                                               47.403                                                                             24.059                                                                             -15.709                                                                            1.00                                                                              22.93                                        ATOM  4549                                                                              CD2 LEU                                                                               627                                                                               45.351                                                                             24.073                                                                             -14.391                                                                            1.00                                                                              28.78                                        ATOM  4550                                                                              C   LEU                                                                               627                                                                               44.271                                                                             26.838                                                                             -17.208                                                                            1.00                                                                              29.90                                        ATOM  4551                                                                              O   LEU                                                                               627                                                                               43.467                                                                             27.467                                                                             -16.538                                                                            1.00                                                                              33.36                                        ATOM  4552                                                                              N   ILE                                                                               628                                                                               43.912                                                                             26.083                                                                             -18.241                                                                            1.00                                                                              30.36                                        ATOM  4553                                                                              CA  ILE                                                                               628                                                                               42.519                                                                             25.902                                                                             -18.620                                                                            1.00                                                                              25.02                                        ATOM  4554                                                                              CB  ILE                                                                               628                                                                               42.269                                                                             26.290                                                                             -20.073                                                                            1.00                                                                              25.94                                        ATOM  4555                                                                              CG2 ILE                                                                               628                                                                               40.813                                                                             26.445                                                                             -20.299                                                                            1.00                                                                              34.05                                        ATOM  4556                                                                              CG1 ILE                                                                               628                                                                               43.022                                                                             27.565                                                                             -20.466                                                                            1.00                                                                              27.41                                        ATOM  4557                                                                              CD1 ILE                                                                               628                                                                               42.755                                                                             28.745                                                                             -19.614                                                                            1.00                                                                              29.63                                        ATOM  4558                                                                              C   ILE                                                                               628                                                                               42.263                                                                             24.411                                                                             -18.541                                                                            1.00                                                                              26.03                                        ATOM  4559                                                                              O   ILE                                                                               628                                                                               43.131                                                                             23.609                                                                             -18.886                                                                            1.00                                                                              28.68                                        ATOM  4560                                                                              N   ILE                                                                               629                                                                               41.090                                                                             24.033                                                                             -18.057                                                                            1.00                                                                              28.18                                        ATOM  4561                                                                              CA  ILE                                                                               629                                                                               40.700                                                                             22.627                                                                             -17.960                                                                            1.00                                                                              25.83                                        ATOM  4562                                                                              CB  ILE                                                                               629                                                                               40.135                                                                             22.262                                                                             -16.550                                                                            1.00                                                                              29.86                                        ATOM  4563                                                                              CG2 ILE                                                                               629                                                                               39.803                                                                             20.774                                                                             -16.463                                                                            1.00                                                                              32.13                                        ATOM  4564                                                                              CG1 ILE                                                                               629                                                                               41.152                                                                             22.594                                                                             -15.466                                                                            1.00                                                                              36.05                                        ATOM  4565                                                                              CD1 ILE                                                                               629                                                                               42.503                                                                             21.916                                                                             -15.642                                                                            1.00                                                                              41.73                                        ATOM  4566                                                                              C   ILE                                                                               629                                                                               39.561                                                                             22.478                                                                             -18.967                                                                            1.00                                                                              23.61                                        ATOM  4567                                                                              O   ILE                                                                               629                                                                               38.693                                                                             23.343                                                                             -19.063                                                                            1.00                                                                              19.96                                        ATOM  4568                                                                              N   GLY                                                                               630                                                                               39.558                                                                             21.396                                                                             -19.721                                                                            1.00                                                                              20.85                                        ATOM  4569                                                                              CA  GLY                                                                               630                                                                               38.500                                                                             21.188                                                                             -20.682                                                                            1.00                                                                              23.85                                        ATOM  4570                                                                              C   GLY                                                                               630                                                                               38.068                                                                             19.749                                                                             -20.561                                                                            1.00                                                                              23.37                                        ATOM  4571                                                                              O   GLY                                                                               630                                                                               38.690                                                                             19.001                                                                             -19.823                                                                            1.00                                                                              24.82                                        ATOM  4572                                                                              N   ALA                                                                               631                                                                               37.033                                                                             19.350                                                                             -21.286                                                                            1.00                                                                              20.81                                        ATOM  4573                                                                              CA  ALA                                                                               631                                                                               36.569                                                                             17.982                                                                             -21.226                                                                            1.00                                                                              23.26                                        ATOM  4574                                                                              CB  ALA                                                                               631                                                                               35.565                                                                             17.804                                                                             -20.091                                                                            1.00                                                                              20.73                                        ATOM  4575                                                                              C   ALA                                                                               631                                                                               35.916                                                                             17.661                                                                             -22.557                                                                            1.00                                                                              27.62                                        ATOM  4576                                                                              O   ALA                                                                               631                                                                               35.650                                                                             18.556                                                                             -23.356                                                                            1.00                                                                              29.95                                        ATOM  4577                                                                              N   GLU                                                                               632                                                                               35.732                                                                             16.377                                                                             -22.829                                                                            1.00                                                                              31.92                                        ATOM  4578                                                                              CA  GLU                                                                               632                                                                               35.078                                                                             15.963                                                                             -24.059                                                                            1.00                                                                              32.85                                        ATOM  4579                                                                              CB  GLU                                                                               632                                                                               35.650                                                                             14.644                                                                             -24.570                                                                            1.00                                                                              31.26                                        ATOM  4580                                                                              CG  GLU                                                                               632                                                                               35.053                                                                             13.414                                                                             -23.921                                                                            1.00                                                                              27.95                                        ATOM  4581                                                                              CD  GLU                                                                               632                                                                               35.713                                                                             12.143                                                                             -24.385                                                                            1.00                                                                              36.80                                        ATOM  4582                                                                              OE1 GLU                                                                               632                                                                               36.369                                                                             12.154                                                                             -25.451                                                                            1.00                                                                              40.53                                        ATOM  4583                                                                              OE2 GLU                                                                               632                                                                               35.590                                                                             11.123                                                                             -23.678                                                                            1.00                                                                              41.05                                        ATOM  4584                                                                              C   GLU                                                                               632                                                                               33.625                                                                             15.776                                                                             -23.674                                                                            1.00                                                                              33.61                                        ATOM  4585                                                                              O   GLU                                                                               632                                                                               33.280                                                                             15.718                                                                             -22.494                                                                            1.00                                                                              38.27                                        ATOM  4586                                                                              N   SER                                                                               633                                                                               32.788                                                                             15.582                                                                             -24.665                                                                            1.00                                                                              32.84                                        ATOM  4587                                                                              CA  SER                                                                               633                                                                               31.371                                                                             15.420                                                                             -24.418                                                                            1.00                                                                              35.35                                        ATOM  4588                                                                              CB  SER                                                                               633                                                                               30.627                                                                             15.688                                                                             -25.723                                                                            1.00                                                                              38.12                                        ATOM  4589                                                                              OG  SER                                                                               633                                                                               30.955                                                                             16.994                                                                             -26.189                                                                            1.00                                                                              46.45                                        ATOM  4590                                                                              C   SER                                                                               633                                                                               30.937                                                                             14.092                                                                             -23.809                                                                            1.00                                                                              34.15                                        ATOM  4591                                                                              O   SER                                                                               633                                                                               31.566                                                                             13.058                                                                             -24.025                                                                            1.00                                                                              35.25                                        ATOM  4592                                                                              N   PHE                                                                               634                                                                               29.839                                                                             14.135                                                                             -23.064                                                                            1.00                                                                              34.80                                        ATOM  4593                                                                              CA  PHE                                                                               634                                                                               29.262                                                                             12.960                                                                             -22.419                                                                            1.00                                                                              37.23                                        ATOM  4594                                                                              CB  PHE                                                                               634                                                                               29.754                                                                             12.854                                                                             -20.976                                                                            1.00                                                                              34.83                                        ATOM  4595                                                                              CG  PHE                                                                               634                                                                               29.346                                                                             14.010                                                                             -20.117                                                                            1.00                                                                              30.25                                        ATOM  4596                                                                              CD1 PHE                                                                               634                                                                               28.262                                                                             13.895                                                                             -19.245                                                                            1.00                                                                              28.96                                        ATOM  4597                                                                              CD2 PHE                                                                               634                                                                               30.016                                                                             15.226                                                                             -20.203                                                                            1.00                                                                              27.74                                        ATOM  4598                                                                              CE1 PHE                                                                               634                                                                               27.846                                                                             14.974                                                                             -18.475                                                                            1.00                                                                              24.91                                        ATOM  4599                                                                              CE2 PHE                                                                               634                                                                               29.610                                                                             16.314                                                                             -19.437                                                                            1.00                                                                              29.50                                        ATOM  4600                                                                              CZ  PHE                                                                               634                                                                               28.520                                                                             16.187                                                                             -18.571                                                                            1.00                                                                              25.99                                        ATOM  4601                                                                              C   PHE                                                                               634                                                                               27.746                                                                             13.173                                                                             -22.433                                                                            1.00                                                                              42.26                                        ATOM  4602                                                                              O   PHE                                                                               634                                                                               27.280                                                                             14.313                                                                             -22.607                                                                            1.00                                                                              43.66                                        ATOM  4603                                                                              N   VAL                                                                               635                                                                               26.969                                                                             12.105                                                                             -22.263                                                                            1.00                                                                              44.81                                        ATOM  4604                                                                              CA  VAL                                                                               635                                                                               25.510                                                                             12.249                                                                             -22.268                                                                            1.00                                                                              49.75                                        ATOM  4605                                                                              CB  VAL                                                                               635                                                                               24.773                                                                             10.914                                                                             -22.408                                                                            1.00                                                                              48.09                                        ATOM  4606                                                                              CG1 VAL                                                                               635                                                                               24.749                                                                             10.479                                                                             -23.868                                                                            1.00                                                                              54.19                                        ATOM  4607                                                                              CG2 VAL                                                                               635                                                                               25.427                                                                             9.860                                                                              -21.545                                                                            1.00                                                                              48.38                                        ATOM  4608                                                                              C   VAL                                                                               635                                                                               25.045                                                                             12.875                                                                             -20.989                                                                            1.00                                                                              52.73                                        ATOM  4609                                                                              O   VAL                                                                               635                                                                               25.668                                                                             12.694                                                                             -19.947                                                                            1.00                                                                              56.22                                        ATOM  4610                                                                              N   SER                                                                               636                                                                               23.955                                                                             13.622                                                                             -21.064                                                                            1.00                                                                              56.71                                        ATOM  4611                                                                              CA  SER                                                                               636                                                                               23.401                                                                             14.258                                                                             -19.876                                                                            1.00                                                                              60.84                                        ATOM  4612                                                                              CB  SER                                                                               636                                                                               22.250                                                                             15.197                                                                             -20.266                                                                            1.00                                                                              66.55                                        ATOM  4613                                                                              OG  SER                                                                               636                                                                               21.286                                                                             14.545                                                                             -21.094                                                                            1.00                                                                              74.32                                        ATOM  4614                                                                              C   SER                                                                               636                                                                               22.925                                                                             13.169                                                                             -18.895                                                                            1.00                                                                              59.04                                        ATOM  4615                                                                              O   SER                                                                               636                                                                               22.573                                                                             12.049                                                                             -19.303                                                                            1.00                                                                              58.56                                        ATOM  4616                                                                              N   GLY                                                                               637                                                                               22.934                                                                             13.489                                                                             -17.605                                                                            1.00                                                                              55.58                                        ATOM  4617                                                                              CA  GLY                                                                               637                                                                               22.523                                                                             12.511                                                                             -16.616                                                                            1.00                                                                              52.89                                        ATOM  4618                                                                              C   GLY                                                                               637                                                                               23.713                                                                             11.817                                                                             -15.963                                                                            1.00                                                                              50.21                                        ATOM  4619                                                                              O   GLY                                                                               637                                                                               23.534                                                                             10.968                                                                             -15.100                                                                            1.00                                                                              54.08                                        ATOM  4620                                                                              N   GLU                                                                               638                                                                               24.924                                                                             12.120                                                                             -16.417                                                                            1.00                                                                              45.05                                        ATOM  4621                                                                              CA  GLU                                                                               638                                                                               26.123                                                                             11.544                                                                             -15.830                                                                            1.00                                                                              38.98                                        ATOM  4622                                                                              CB  GLU                                                                               638                                                                               27.134                                                                             11.150                                                                             -16.902                                                                            1.00                                                                              40.82                                        ATOM  4623                                                                              CG  GLU                                                                               638                                                                               26.651                                                                             10.070                                                                             -17.846                                                                            1.00                                                                              41.29                                        ATOM  4624                                                                              CD  GLU                                                                               638                                                                               26.536                                                                             8.713                                                                              -17.198                                                                            1.00                                                                              44.15                                        ATOM  4625                                                                              OE1 GLU                                                                               638                                                                               26.859                                                                             8.570                                                                              -16.008                                                                            1.00                                                                              51.56                                        ATOM  4626                                                                              OE2 GLU                                                                               638                                                                               26.140                                                                             7.758                                                                              -17.887                                                                            1.00                                                                              48.24                                        ATOM  4627                                                                              C   GLU                                                                               638                                                                               26.694                                                                             12.632                                                                             -14.936                                                                            1.00                                                                              37.82                                        ATOM  4628                                                                              O   GLU                                                                               638                                                                               26.748                                                                             13.809                                                                             -15.318                                                                            1.00                                                                              40.61                                        ATOM  4629                                                                              N   LYS                                                                               639                                                                               27.078                                                                             12.246                                                                             -13.730                                                                            1.00                                                                              31.64                                        ATOM  4630                                                                              CA  LYS                                                                               639                                                                               27.601                                                                             13.190                                                                             -12.765                                                                            1.00                                                                              25.56                                        ATOM  4631                                                                              CB  LYS                                                                               639                                                                               27.080                                                                             12.853                                                                             -11.366                                                                            1.00                                                                              29.28                                        ATOM  4632                                                                              CG  LYS                                                                               639                                                                               25.593                                                                             12.600                                                                             -11.246                                                                            1.00                                                                              34.14                                        ATOM  4633                                                                              CD  LYS                                                                               639                                                                               25.316                                                                             11.994                                                                             -9.867                                                                             1.00                                                                              48.20                                        ATOM  4634                                                                              CE  LYS                                                                               639                                                                               23.830                                                                             11.816                                                                             -9.571                                                                             1.00                                                                              50.33                                        ATOM  4635                                                                              NZ  LYS                                                                               639                                                                               23.172                                                                             10.838                                                                             -10.481                                                                            1.00                                                                              57.45                                        ATOM  4636                                                                              C   LYS                                                                               639                                                                               29.110                                                                             13.139                                                                             -12.733                                                                            1.00                                                                              20.16                                        ATOM  4637                                                                              O   LYS                                                                               639                                                                               29.686                                                                             12.056                                                                             -12.594                                                                            1.00                                                                              21.41                                        ATOM  4638                                                                              N   ILE                                                                               640                                                                               29.734                                                                             14.308                                                                             -12.856                                                                            1.00                                                                              16.72                                        ATOM  4639                                                                              CA  ILE                                                                               640                                                                               31.177                                                                             14.457                                                                             -12.802                                                                            1.00                                                                              13.62                                        ATOM  4640                                                                              CB  ILE                                                                               640                                                                               31.825                                                                             14.866                                                                             -14.158                                                                            1.00                                                                              13.79                                        ATOM  4641                                                                              CG2 ILE                                                                               640                                                                               33.295                                                                             15.154                                                                             -13.943                                                                            1.00                                                                              15.50                                        ATOM  4642                                                                              CG1 ILE                                                                               640                                                                               31.751                                                                             13.734                                                                             -15.191                                                                            1.00                                                                              13.55                                        ATOM  4643                                                                              CD1 ILE                                                                               640                                                                               30.610                                                                             13.831                                                                             -16.190                                                                            1.00                                                                              11.62                                        ATOM  4644                                                                              C   ILE                                                                               640                                                                               31.418                                                                             15.572                                                                             -11.809                                                                            1.00                                                                              18.26                                        ATOM  4645                                                                              O   ILE                                                                               640                                                                               30.845                                                                             16.646                                                                             -11.936                                                                            1.00                                                                              20.94                                        ATOM  4646                                                                              N   TYR                                                                               641                                                                               32.210                                                                             15.288                                                                             -10.778                                                                            1.00                                                                              20.12                                        ATOM  4647                                                                              CA  TYR                                                                               641                                                                               32.548                                                                             16.254                                                                             -9.741                                                                             1.00                                                                              17.06                                        ATOM  4648                                                                              CB  TYR                                                                               641                                                                               32.093                                                                             15.736                                                                             -8.394                                                                             1.00                                                                              12.33                                        ATOM  4649                                                                              CG  TYR                                                                               641                                                                               30.629                                                                             15.427                                                                             -8.353                                                                             1.00                                                                              19.71                                        ATOM  4650                                                                              CD1 TYR                                                                               641                                                                               30.170                                                                             14.134                                                                             -8.582                                                                             1.00                                                                              20.72                                        ATOM  4651                                                                              CE1 TYR                                                                               641                                                                               28.821                                                                             13.833                                                                             -8.508                                                                             1.00                                                                              25.35                                        ATOM  4652                                                                              CD2 TYR                                                                               641                                                                               29.697                                                                             16.421                                                                             -8.050                                                                             1.00                                                                              18.05                                        ATOM  4653                                                                              CE2 TYR                                                                               641                                                                               28.358                                                                             16.132                                                                             -7.968                                                                             1.00                                                                              26.09                                        ATOM  4654                                                                              CZ  TYR                                                                               641                                                                               27.924                                                                             14.834                                                                             -8.191                                                                             1.00                                                                              24.94                                        ATOM  4655                                                                              OH  TYR                                                                               641                                                                               26.597                                                                             14.530                                                                             -8.023                                                                             1.00                                                                              32.32                                        ATOM  4656                                                                              C   TYR                                                                               641                                                                               34.060                                                                             16.389                                                                             -9.708                                                                             1.00                                                                              18.01                                        ATOM  4657                                                                              O   TYR                                                                               641                                                                               34.779                                                                             15.391                                                                             -9.614                                                                             1.00                                                                              18.42                                        ATOM  4658                                                                              N   ILE                                                                               642                                                                               34.550                                                                             17.606                                                                             -9.833                                                                             1.00                                                                              16.45                                        ATOM  4659                                                                              CA  ILE                                                                               642                                                                               35.988                                                                             17.808                                                                             -9.791                                                                             1.00                                                                              20.87                                        ATOM  4660                                                                              CB  ILE                                                                               642                                                                               36.491                                                                             18.575                                                                             -11.029                                                                            1.00                                                                              20.47                                        ATOM  4661                                                                              CG2 ILE                                                                               642                                                                               37.958                                                                             18.793                                                                             -10.911                                                                            1.00                                                                              20.81                                        ATOM  4662                                                                              CG1 ILE                                                                               642                                                                               36.235                                                                             17.760                                                                             -12.306                                                                            1.00                                                                              19.36                                        ATOM  4663                                                                              CD1 ILE                                                                               642                                                                               36.571                                                                             18.515                                                                             -13.566                                                                            1.00                                                                              21.85                                        ATOM  4664                                                                              C   ILE                                                                               642                                                                               36.246                                                                             18.593                                                                             -8.512                                                                             1.00                                                                              20.68                                        ATOM  4665                                                                              O   ILE                                                                               642                                                                               35.470                                                                             19.494                                                                             -8.187                                                                             1.00                                                                              22.38                                        ATOM  4666                                                                              N   ASP                                                                               643                                                                               37.304                                                                             18.230                                                                             -7.783                                                                             1.00                                                                              20.18                                        ATOM  4667                                                                              CA  ASP                                                                               643                                                                               37.655                                                                             18.879                                                                             -6.508                                                                             1.00                                                                              18.65                                        ATOM  4668                                                                              CB  ASP                                                                               643                                                                               37.531                                                                             17.821                                                                             -5.382                                                                             1.00                                                                              22.35                                        ATOM  4669                                                                              CG  ASP                                                                               643                                                                               38.028                                                                             18.294                                                                             -4.024                                                                             1.00                                                                              26.15                                        ATOM  4670                                                                              OD1 ASP                                                                               643                                                                               37.750                                                                             19.453                                                                             -3.625                                                                             1.00                                                                              25.20                                        ATOM  4671                                                                              OD2 ASP                                                                               643                                                                               38.684                                                                             17.464                                                                             -3.338                                                                             1.00                                                                              24.16                                        ATOM  4672                                                                              C   ASP                                                                               643                                                                               39.030                                                                             19.587                                                                             -6.511                                                                             1.00                                                                              20.45                                        ATOM  4673                                                                              O   ASP                                                                               643                                                                               39.096                                                                             20.821                                                                             -6.361                                                                             1.00                                                                              24.99                                        ATOM  4674                                                                              N   LYS                                                                               644                                                                               40.116                                                                             18.842                                                                             -6.724                                                                             1.00                                                                              16.96                                        ATOM  4675                                                                              CA  LYS                                                                               644                                                                               41.457                                                                             19.428                                                                             -6.714                                                                             1.00                                                                              17.58                                        ATOM  4676                                                                              CB  LYS                                                                               644                                                                               42.246                                                                             18.997                                                                             -5.470                                                                             1.00                                                                              19.80                                        ATOM  4677                                                                              CG  LYS                                                                               644                                                                               41.6&2                                                                             19.216                                                                             -4.117                                                                             1.00                                                                              22.38                                        ATOM  4678                                                                              CD  LYS                                                                               644                                                                               41.412                                                                             20.668                                                                             -3.773                                                                             1.00                                                                              23.96                                        ATOM  4679                                                                              CE  LYS                                                                               644                                                                               41.051                                                                             20.791                                                                             -2.310                                                                             1.00                                                                              20.00                                        ATOM  4680                                                                              NZ  LYS                                                                               644                                                                               40.046                                                                             19.745                                                                             -1.948                                                                             1.00                                                                              20.46                                        ATOM  4681                                                                              C   LYS                                                                               644                                                                               42.332                                                                             19.024                                                                             -7.884                                                                             1.00                                                                              18.74                                        ATOM  4682                                                                              O   LYS                                                                               644                                                                               42.322                                                                             17.872                                                                             -8.296                                                                             1.00                                                                              21.48                                        ATOM  4683                                                                              N   ILE                                                                               645                                                                               43.168                                                                             19.954                                                                             -8.329                                                                             1.00                                                                              17.54                                        ATOM  4684                                                                              CA  ILE                                                                               645                                                                               44.132                                                                             19.717                                                                             -9.388                                                                             1.00                                                                              17.59                                        ATOM  4685                                                                              CB  ILE                                                                               645                                                                               44.241                                                                             20.931                                                                             -10.352                                                                            1.00                                                                              21.58                                        ATOM  4686                                                                              CG2 ILE                                                                               645                                                                               45.150                                                                             20.602                                                                             -11.541                                                                            1.00                                                                              23.33                                        ATOM  4687                                                                              CG1 ILE                                                                               645                                                                               42.860                                                                             21.330                                                                             -10.878                                                                            1.00                                                                              25.80                                        ATOM  4688                                                                              CD1 ILE                                                                               645                                                                               42.170                                                                             20.258                                                                             -11.698                                                                            1.00                                                                              23.99                                        ATOM  4689                                                                              C   ILE                                                                               645                                                                               45.416                                                                             19.643                                                                             -8.565                                                                             1.00                                                                              16.72                                        ATOM  4690                                                                              O   ILE                                                                               645                                                                               45.684                                                                             20.540                                                                             -7.782                                                                             1.00                                                                              19.90                                        ATOM  4691                                                                              N   GLU                                                                               646                                                                               46.185                                                                             18.568                                                                             -8.686                                                                             1.00                                                                              18.31                                        ATOM  4692                                                                              CA  GLU                                                                               646                                                                               47.429                                                                             18.450                                                                             -7.922                                                                             1.00                                                                              16.72                                        ATOM  4693                                                                              CB  GLU                                                                               646                                                                               47.459                                                                             17.158                                                                             -7.100                                                                             1.00                                                                              13.74                                        ATOM  4694                                                                              CG  GLU                                                                               646                                                                               46.218                                                                             16.841                                                                             -6.292                                                                             1.00                                                                              11.87                                        ATOM  4695                                                                              CD  GLU                                                                               646                                                                               46.475                                                                             15.711                                                                             -5.331                                                                             1.00                                                                              21.72                                        ATOM  4696                                                                              OE1 GLU                                                                               646                                                                               47.074                                                                             14.707                                                                             -5.762                                                                             1.00                                                                              22.74                                        ATOM  4697                                                                              OE2 GLU                                                                               646                                                                               46.104                                                                             15.822                                                                             -4.146                                                                             1.00                                                                              25.76                                        ATOM  4698                                                                              C   GLU                                                                               646                                                                               48.679                                                                             18.501                                                                             -8.804                                                                             1.00                                                                              15.32                                        ATOM  4699                                                                              O   GLU                                                                               646                                                                               48.728                                                                             17.894                                                                             -9.855                                                                             1.00                                                                              17.66                                        ATOM  4700                                                                              N   PHE                                                                               647                                                                               49.701                                                                             19.198                                                                             -8.337                                                                             1.00                                                                              18.90                                        ATOM  4701                                                                              CA  PHE                                                                               647                                                                               50.950                                                                             19.316                                                                             -9.060                                                                             1.00                                                                              20.74                                        ATOM  4702                                                                              CB  PHE                                                                               647                                                                               51.299                                                                             20.783                                                                             -9.253                                                                             1.00                                                                              22.54                                        ATOM  4703                                                                              CG  PHE                                                                               647                                                                               50.309                                                                             21.508                                                                             -10.096                                                                            1.00                                                                              16.80                                        ATOM  4704                                                                              CD1 PHE                                                                               647                                                                               49.263                                                                             22.185                                                                             -9.513                                                                             1.00                                                                              15.88                                        ATOM  4705                                                                              CD2 PHE                                                                               647                                                                               50.388                                                                             21.442                                                                             -11.474                                                                            1.00                                                                              15.98                                        ATOM  4706                                                                              CE1 PHE                                                                               647                                                                               48.297                                                                             22.779                                                                             -10.285                                                                            1.00                                                                              19.07                                        ATOM  4707                                                                              CE2 PHE                                                                               647                                                                               49.440                                                                             22.026                                                                             -12.251                                                                            1.00                                                                              17.20                                        ATOM  4708                                                                              CZ  PHE                                                                               647                                                                               48.385                                                                             22.699                                                                             -11.658                                                                            1.00                                                                              21.92                                        ATOM  4709                                                                              C   PHE                                                                               647                                                                               52.048                                                                             18.597                                                                             -8.327                                                                             1.00                                                                              23.01                                        ATOM  4710                                                                              O   PHE                                                                               647                                                                               52.285                                                                             18.827                                                                             -7.145                                                                             1.00                                                                              25.26                                        ATOM  4711                                                                              N   ILE                                                                               648                                                                               52.682                                                                             17.676                                                                             -9.032                                                                             1.00                                                                              27.24                                        ATOM  4712                                                                              CA  ILE                                                                               648                                                                               53.766                                                                             16.884                                                                             -8.481                                                                             1.00                                                                              28.26                                        ATOM  4713                                                                              CB  ILE                                                                               648                                                                               53.499                                                                             15.385                                                                             -8.728                                                                             1.00                                                                              28.25                                        ATOM  4714                                                                              CG2 ILE                                                                               648                                                                               54.433                                                                             14.542                                                                             -7.874                                                                             1.00                                                                              30.94                                        ATOM  4715                                                                              CG1 ILE                                                                               648                                                                               52.033                                                                             15.045                                                                             -8.428                                                                             1.00                                                                              26.62                                        ATOM  4716                                                                              CD1 ILE                                                                               648                                                                               51.634                                                                             13.616                                                                             -8.796                                                                             1.00                                                                              24.38                                        ATOM  4717                                                                              C   ILE                                                                               648                                                                               55.009                                                                             17.299                                                                             -9.260                                                                             1.00                                                                              29.24                                        ATOM  4718                                                                              O   ILE                                                                               648                                                                               54.979                                                                             17.314                                                                             -10.488                                                                            1.00                                                                              29.14                                        ATOM  4719                                                                              N   PRO                                                                               649                                                                               56.079                                                                             17.735                                                                             -8.566                                                                             1.00                                                                              29.81                                        ATOM  4720                                                                              CD  PRO                                                                               649                                                                               56.096                                                                             18.156                                                                             -7.167                                                                             1.00                                                                              26.84                                        ATOM  4721                                                                              CA  PRO                                                                               649                                                                               57.323                                                                             18.153                                                                             -9.232                                                                             1.00                                                                              33.95                                        ATOM  4722                                                                              CB  PRO                                                                               649                                                                               58.101                                                                             18.818                                                                             -8.111                                                                             1.00                                                                              25.42                                        ATOM  4723                                                                              CG  PRO                                                                               649                                                                               57.039                                                                             19.324                                                                             -7.242                                                                             1.00                                                                              30.57                                        ATOM  4724                                                                              C   PRO                                                                               649                                                                               58.075                                                                             16.947                                                                             -9.760                                                                             1.00                                                                              39.61                                        ATOM  4725                                                                              O   PRO                                                                               649                                                                               58.648                                                                             16.186                                                                             -8.980                                                                             1.00                                                                              44.73                                        ATOM  4726                                                                              N   VAL                                                                               650                                                                               58.046                                                                             16.755                                                                             -11.075                                                                            1.00                                                                              44.21                                        ATOM  4727                                                                              CA  VAL                                                                               650                                                                               58.714                                                                             15.616                                                                             -11.696                                                                            1.00                                                                              48.14                                        ATOM  4728                                                                              CB  VAL                                                                               650                                                                               58.401                                                                             15.483                                                                             -13.180                                                                            1.00                                                                              45.37                                        ATOM  4729                                                                              CG1 VAL                                                                               650                                                                               59.150                                                                             14.313                                                                             -13.731                                                                            1.00                                                                              47.12                                        ATOM  4730                                                                              CG2 VAL                                                                               650                                                                               56.923                                                                             15.311                                                                             -13.407                                                                            1.00                                                                              44.38                                        ATOM  4731                                                                              C   VAL                                                                               650                                                                               60.196                                                                             15.817                                                                             -11.595                                                                            1.00                                                                              54.89                                        ATOM  4732                                                                              O   VAL                                                                               650                                                                               60.766                                                                             16.662                                                                             -12.294                                                                            1.00                                                                              56.42                                        ATOM  4733                                                                              N   GLN                                                                               651                                                                               60.817                                                                             15.043                                                                             -10.718                                                                            1.00                                                                              62.10                                        ATOM  4734                                                                              CA  GLN                                                                               651                                                                               62.253                                                                             15.136                                                                             -10.510                                                                            1.00                                                                              71.53                                        ATOM  4735                                                                              CB  GLN                                                                               651                                                                               62.568                                                                             15.175                                                                             -9.013                                                                             1.00                                                                              74.84                                        ATOM  4736                                                                              CG  GLN                                                                               651                                                                               61.980                                                                             16.384                                                                             -8.294                                                                             1.00                                                                              80.23                                        ATOM  4737                                                                              CD  GLN                                                                               651                                                                               62.380                                                                             16.453                                                                             -6.828                                                                             1.00                                                                              86.44                                        ATOM  4738                                                                              OE1 GLN                                                                               651                                                                               61.827                                                                             17.251                                                                             -6.065                                                                             1.00                                                                              88.07                                        ATOM  4739                                                                              NE2 GLN                                                                               651                                                                               63.341                                                                             15.616                                                                             -6.420                                                                             1.00                                                                              88.91                                        ATOM  4740                                                                              C   GLN                                                                               651                                                                               62.978                                                                             13.981                                                                             -11.185                                                                            1.00                                                                              75.09                                        ATOM  4741                                                                              O   GLN                                                                               651                                                                               63.591                                                                             13.140                                                                             -10.517                                                                            1.00                                                                              76.97                                        ATOM  4742                                                                              N   LEU                                                                               652                                                                               62.892                                                                             13.966                                                                             -12.513                                                                            1.00                                                                              78.20                                        ATOM  4743                                                                              CA  LEU                                                                               652                                                                               63.505                                                                             12.943                                                                             -13.354                                                                            1.00                                                                              80.82                                        ATOM  4744                                                                              CB  LEU                                                                               652                                                                               63.468                                                                             13.404                                                                             -14.811                                                                            1.00                                                                              83.43                                        ATOM  4745                                                                              CG  LEU                                                                               652                                                                               62.069                                                                             13.518                                                                             -15.418                                                                            1.00                                                                              84.78                                        ATOM  4746                                                                              CD1 LEU                                                                               652                                                                               62.119                                                                             14.172                                                                             -16.798                                                                            1.00                                                                              86.36                                        ATOM  4747                                                                              CD2 LEU                                                                               652                                                                               61.447                                                                             12.120                                                                             -15.483                                                                            1.00                                                                              85.69                                        ATOM  4748                                                                              C   LEU                                                                               652                                                                               64.942                                                                             12.620                                                                             -12.960                                                                            1.00                                                                              82.59                                        ATOM  4749                                                                              OT1 LEU                                                                               652                                                                               65.216                                                                             11.449                                                                             -12.608                                                                            1.00                                                                              84.20                                        ATOM  4750                                                                              OT2 LEU                                                                               652                                                                               65.772                                                                             13.555                                                                             -13.013                                                                            1.00                                                                              86.03                                        ATOM  4751                                                                              O   HOH                                                                               1  39.600                                                                             24.576                                                                             11.813                                                                             1.00                                                                              12.17                                        ATOM  4752                                                                              O   HOH                                                                               2  40.792                                                                             27.069                                                                             11.597                                                                             1.00                                                                              25.65                                        ATOM  4753                                                                              O   HOH                                                                               3  43.758                                                                             26.829                                                                             11.570                                                                             1.00                                                                              13.86                                        ATOM  4754                                                                              O   HOH                                                                               4  55.446                                                                             23.281                                                                             8.689                                                                              1.00                                                                              39.72                                        ATOM  4755                                                                              O   HOH                                                                               5  54.367                                                                             13.815                                                                             2.943                                                                              1.00                                                                              30.80                                        ATOM  4756                                                                              O   HOH                                                                               6  57.911                                                                             14.284                                                                             16.519                                                                             1.00                                                                              30.98                                        ATOM  4757                                                                              O   HOH                                                                               7  38.642                                                                             1.242                                                                              15.206                                                                             1.00                                                                              35.24                                        ATOM  4758                                                                              O   HOH                                                                               8  39.462                                                                             -1.232                                                                             13.462                                                                             1.00                                                                              39.99                                        ATOM  4759                                                                              O   HOH                                                                               9  30.581                                                                             9.208                                                                              17.185                                                                             1.00                                                                              12.58                                        ATOM  4760                                                                              O   HOH                                                                               10 43.871                                                                             15.044                                                                             17.131                                                                             1.00                                                                              13.07                                        ATOM  4761                                                                              O   HOH                                                                               11 57.356                                                                             -3.646                                                                             2.453                                                                              1.00                                                                              47.02                                        ATOM  4762                                                                              O   HOH                                                                               12 45.059                                                                             -5.877                                                                             8.478                                                                              1.00                                                                              34.13                                        ATOM  4763                                                                              O   HOH                                                                               13 42.458                                                                             6.455                                                                              1.498                                                                              1.00                                                                              37.54                                        ATOM  4764                                                                              O   HOH                                                                               14 38.876                                                                             8.797                                                                              -1.848                                                                             1.00                                                                              29.14                                        ATOM  4765                                                                              O   HOH                                                                               15 29.008                                                                             5.736                                                                              8.141                                                                              1.00                                                                              33.53                                        ATOM  4766                                                                              O   HOH                                                                               16 26.319                                                                             10.581                                                                             4.483                                                                              0.50                                                                              34.39                                        ATOM  4767                                                                              O   HOH                                                                               17 28.858                                                                             9.435                                                                              5.261                                                                              1.00                                                                              27.54                                        ATOM  4768                                                                              O   HOH                                                                               18 30.989                                                                             23.542                                                                             6.740                                                                              1.00                                                                              27.62                                        ATOM  4769                                                                              O   HOH                                                                               19 29.511                                                                             28.588                                                                             9.501                                                                              1.00                                                                              33.81                                        ATOM  4770                                                                              O   HOH                                                                               20 45.641                                                                             8.025                                                                              6.242                                                                              1.00                                                                              20.04                                        ATOM  4771                                                                              O   HOH                                                                               21 57.722                                                                             6.464                                                                              1.525                                                                              1.00                                                                              54.78                                        ATOM  4772                                                                              O   HOH                                                                               22 48.699                                                                             27.494                                                                             1.748                                                                              1.00                                                                              30.06                                        ATOM  4773                                                                              O   HOH                                                                               23 22.565                                                                             23.551                                                                             4.174                                                                              1.00                                                                              50.71                                        ATOM  4774                                                                              O   HOH                                                                               24 31.780                                                                             26.111                                                                             1.799                                                                              1.00                                                                              36.59                                        ATOM  4775                                                                              O   HOH                                                                               25 35.833                                                                             19.538                                                                             5.174                                                                              1.00                                                                              22.44                                        ATOM  4776                                                                              O   HOH                                                                               26 31.698                                                                             41.144                                                                             14.808                                                                             1.00                                                                              26.75                                        ATOM  4777                                                                              O   HOH                                                                               27 22.848                                                                             21.286                                                                             -7.106                                                                             0.50                                                                              44.55                                        ATOM  4778                                                                              O   HOH                                                                               28 28.149                                                                             35.263                                                                             -5.749                                                                             0.50                                                                              27.52                                        ATOM  4779                                                                              O   HOH                                                                               29 38.768                                                                             38.465                                                                             1.897                                                                              1.00                                                                              23.59                                        ATOM  4780                                                                              O   HOH                                                                               30 36.036                                                                             48.871                                                                             -3.323                                                                             1.00                                                                              37.96                                        ATOM  4781                                                                              O   HOH                                                                               31 15.228                                                                             54.291                                                                             25.146                                                                             1.00                                                                              38.59                                        ATOM  4782                                                                              O   HOH                                                                               32 30.188                                                                             40.575                                                                             -3.853                                                                             1.00                                                                              25.30                                        ATOM  4783                                                                              O   HOH                                                                               33 41.541                                                                             42.499                                                                             -1.499                                                                             1.00                                                                              33.25                                        ATOM  4784                                                                              O   HOH                                                                               34 38.585                                                                             45.910                                                                             14.986                                                                             1.00                                                                              46.67                                        ATOM  4785                                                                              O   HOH                                                                               35 39.850                                                                             41.334                                                                             2.080                                                                              1.00                                                                              44.36                                        ATOM  4786                                                                              O   HOH                                                                               36 42.846                                                                             31.690                                                                             -10.923                                                                            1.00                                                                              21.98                                        ATOM  4787                                                                              O   HOH                                                                               37 43.450                                                                             12.688                                                                             -1.919                                                                             1.00                                                                              24.87                                        ATOM  4788                                                                              O   HOH                                                                               38 39.038                                                                             13.837                                                                             2.118                                                                              1.00                                                                              27.10                                        ATOM  4789                                                                              O   HOH                                                                               39 37.928                                                                             5.313                                                                              -6.284                                                                             1.00                                                                              50.72                                        ATOM  4790                                                                              O   HOH                                                                               40 24.875                                                                             4.116                                                                              -12.560                                                                            0.50                                                                              29.43                                        ATOM  4791                                                                              O   HOH                                                                               41 55.553                                                                             35.810                                                                             -18.611                                                                            0.50                                                                              42.33                                        ATOM  4792                                                                              O   HOH                                                                               42 46.764                                                                             34.401                                                                             3.319                                                                              1.00                                                                              52.37                                        ATOM  4793                                                                              O   HOH                                                                               43 38.723                                                                             6.598                                                                              -19.519                                                                            1.00                                                                              45.34                                        ATOM  4794                                                                              O   HOH                                                                               44 65.474                                                                             2.330                                                                              6.882                                                                              0.50                                                                              53.47                                        ATOM  4795                                                                              O   HOH                                                                               45 62.312                                                                             4.587                                                                              26.852                                                                             0.50                                                                              32.00                                        ATOM  4796                                                                              O   HOH                                                                               46 71.750                                                                             -5.969                                                                             18.706                                                                             1.00                                                                              37.47                                        ATOM  4797                                                                              O   HOH                                                                               47 58.775                                                                             1.057                                                                              6.153                                                                              1.00                                                                              30.94                                        ATOM  4798                                                                              O   HOH                                                                               48 45.175                                                                             6.998                                                                              1.494                                                                              1.00                                                                              34.82                                        ATOM  4799                                                                              O   HOH                                                                               49 63.008                                                                             22.148                                                                             -6.426                                                                             0.50                                                                              29.98                                        ATOM  4800                                                                              O   HOH                                                                               50 41.462                                                                             18.172                                                                             -0.139                                                                             1.00                                                                              30.33                                        ATOM  4801                                                                              O   HOH                                                                               51 32.560                                                                             21.73                                                                              2.331                                                                              1.00                                                                              29.61                                        ATOM  4802                                                                              O   HOH                                                                               52 14.519                                                                             37.667                                                                             0.321                                                                              0.50                                                                              37.60                                        ATOM  4803                                                                              O   HOH                                                                               53 42.144                                                                             26.546                                                                             23.602                                                                             1.00                                                                              41.27                                        ATOM  4804                                                                              O   HOH                                                                               54 54.172                                                                             23.431                                                                             6.327                                                                              1.00                                                                              37.79                                        ATOM  4805                                                                              O   HOH                                                                               55 58.450                                                                             21.703                                                                             4.673                                                                              1.00                                                                              52.24                                        ATOM  4806                                                                              O   HOH                                                                               56 53.956                                                                             13.326                                                                             12.026                                                                             1.00                                                                              49.78                                        ATOM  4807                                                                              O   HOH                                                                               57 44.302                                                                             20.733                                                                             35.040                                                                             0.50                                                                              36.95                                        ATOM  4808                                                                              O   HOH                                                                               58 25.387                                                                             22.349                                                                             29.206                                                                             1.00                                                                              51.45                                        ATOM  4809                                                                              O   HOH                                                                               59 34.276                                                                             5.690                                                                              35.854                                                                             1.00                                                                              57.79                                        ATOM  4810                                                                              O   HOH                                                                               60 32.551                                                                             5.395                                                                              26.460                                                                             1.00                                                                              44.81                                        ATOM  4811                                                                              O   HOH                                                                               61 68.914                                                                             9.067                                                                              22.100                                                                             1.00                                                                              30.57                                        ATOM  4812                                                                              O   HOH                                                                               62 69.607                                                                             4.862                                                                              7.019                                                                              1.00                                                                              68.86                                        ATOM  4813                                                                              O   HOH                                                                               63 49.122                                                                             -5.437                                                                             19.972                                                                             0.50                                                                              32.90                                        ATOM  4814                                                                              O   HOH                                                                               64 35.071                                                                             2.983                                                                              13.525                                                                             1.00                                                                              57.51                                        ATOM  4815                                                                              O   HOH                                                                               65 69.205                                                                             -0.072                                                                             8.173                                                                              0.50                                                                              30.67                                        ATOM  4816                                                                              O   HOH                                                                               66 59.499                                                                             -8.456                                                                             0.875                                                                              1.00                                                                              42.81                                        ATOM  4817                                                                              O   HOH                                                                               67 43.513                                                                             -7.338                                                                             4.202                                                                              1.00                                                                              58.46                                        ATOM  4818                                                                              O   HOH                                                                               68 24.836                                                                             23.892                                                                             5.544                                                                              1.00                                                                              25.95                                        ATOM  4819                                                                              O   HOH                                                                               69 12.711                                                                             29.928                                                                             21.875                                                                             1.00                                                                              59.62                                        ATOM  4820                                                                              O   HOH                                                                               70 11.349                                                                             34.141                                                                             13.154                                                                             1.00                                                                              37.81                                        ATOM  4821                                                                              O   HOH                                                                               71 24.776                                                                             30.568                                                                             19.682                                                                             1.00                                                                              32.79                                        ATOM  4822                                                                              O   HOH                                                                               72 35.674                                                                             22.015                                                                             5.914                                                                              1.00                                                                              25.68                                        ATOM  4823                                                                              O   HOH                                                                               73 39.992                                                                             22.649                                                                             0.839                                                                              1.00                                                                              26.71                                        ATOM  4824                                                                              O   HOH                                                                               74 33.304                                                                             19.359                                                                             1.262                                                                              1.00                                                                              21.88                                        ATOM  4825                                                                              O   HOH                                                                               75 34.676                                                                             25.968                                                                             -1.544                                                                             1.00                                                                              25.47                                        ATOM  4826                                                                              O   HOH                                                                               76 38.335                                                                             29.492                                                                             3.495                                                                              1.00                                                                              26.33                                        ATOM  4827                                                                              O   HOH                                                                               77 34.285                                                                             32.668                                                                             -0.876                                                                             1.00                                                                              32.85                                        ATOM  4828                                                                              O   HOH                                                                               78 26.762                                                                             34.664                                                                             2.474                                                                              1.00                                                                              38.71                                        ATOM  4829                                                                              O   HOH                                                                               79 26.382                                                                             37.981                                                                             -5.606                                                                             1.00                                                                              42.31                                        ATOM  4830                                                                              O   HOH                                                                               80 14.711                                                                             48.855                                                                             -4.418                                                                             0.50                                                                              35.57                                        ATOM  4831                                                                              O   HOH                                                                               81 48.032                                                                             50.318                                                                             1.569                                                                              1.00                                                                              49.00                                        ATOM  4832                                                                              O   HOH                                                                               82 40.081                                                                             36.290                                                                             12.462                                                                             1.00                                                                              18.52                                        ATOM  4833                                                                              O   HOH                                                                               83 48.045                                                                             27.052                                                                             -4.303                                                                             1.00                                                                              33.60                                        ATOM  4834                                                                              O   HOH                                                                               84 55.768                                                                             32.124                                                                             -2.269                                                                             0.50                                                                              25.70                                        ATOM  4835                                                                              O   HOH                                                                               85 58.944                                                                             26.970                                                                             -4.766                                                                             1.00                                                                              33.86                                        ATOM  4836                                                                              O   HOH                                                                               86 29.248                                                                             24.775                                                                             -22.246                                                                            1.00                                                                              25.41                                        ATOM  4837                                                                              O   HOH                                                                               87 26.155                                                                             13.359                                                                             -0.686                                                                             1.00                                                                              50.23                                        ATOM  4838                                                                              O   HOH                                                                               88 28.166                                                                             13.371                                                                             2.556                                                                              1.00                                                                              53.78                                        ATOM  4839                                                                              O   HOH                                                                               89 31.879                                                                             55.238                                                                             18.930                                                                             0.50                                                                              45.82                                        ATOM  4840                                                                              O   HOH                                                                               90 32.757                                                                             29.484                                                                             16.842                                                                             1.00                                                                              30.62                                        ATOM  4841                                                                              O   HOH                                                                               91 34.578                                                                             30.002                                                                             24.337                                                                             0.50                                                                              45.60                                        ATOM  4842                                                                              O   HOH                                                                               92 66.362                                                                             10.141                                                                             11.805                                                                             1.00                                                                              55.07                                        ATOM  4843                                                                              O   HOH                                                                               93 65.292                                                                             7.242                                                                              12.256                                                                             1.00                                                                              30.58                                        ATOM  4844                                                                              O   HOH                                                                               94 56.297                                                                             13.563                                                                             14.593                                                                             1.00                                                                              24.51                                        ATOM  4845                                                                              O   HOH                                                                               95 45.123                                                                             21.767                                                                             30.085                                                                             1.00                                                                              49.84                                        ATOM  4846                                                                              O   HOH                                                                               96 67.321                                                                             6.836                                                                              9.353                                                                              1.00                                                                              42.45                                        ATOM  4847                                                                              O   HOH                                                                               97 51.532                                                                             37.990                                                                             -11.584                                                                            0.50                                                                              33.54                                        ATOM  4848                                                                              O   HOH                                                                               98 34.637                                                                             24.900                                                                             25.435                                                                             0.50                                                                              36.72                                        ATOM  4849                                                                              O   HOH                                                                               99 47.745                                                                             21.275                                                                             29.129                                                                             1.00                                                                              50.32                                        ATOM  4850                                                                              O   HOH                                                                               100                                                                               29.797                                                                             24.486                                                                             22.331                                                                             1.00                                                                              29.64                                        ATOM  4851                                                                              O   HOH                                                                               101                                                                               22.812                                                                             10.827                                                                             33.352                                                                             0.50                                                                              23.42                                        ATOM  4852                                                                              O   HOH                                                                               102                                                                               30.142                                                                             2.352                                                                              26.582                                                                             1.00                                                                              58.88                                        ATOM  4853                                                                              O   HOH                                                                               103                                                                               42.498                                                                             2.698                                                                              29.895                                                                             1.00                                                                              33.97                                        ATOM  4854                                                                              O   HOH                                                                               104                                                                               45.548                                                                             1.707                                                                              29.609                                                                             1.00                                                                              35.08                                        ATOM  4855                                                                              O   HOH                                                                               105                                                                               73.449                                                                             -5.044                                                                             16.464                                                                             1.00                                                                              48.73                                        ATOM  4856                                                                              O   HOH                                                                               106                                                                               51.401                                                                             5.777                                                                              4.853                                                                              1.00                                                                              37.62                                        ATOM  4857                                                                              O   HOH                                                                               107                                                                               59.811                                                                             -3.998                                                                             4.731                                                                              1.00                                                                              49.23                                        ATOM  4858                                                                              O   HOH                                                                               108                                                                               23.913                                                                             36.019                                                                             17.692                                                                             1.00                                                                              51.86                                        ATOM  4859                                                                              O   HOH                                                                               109                                                                               15.955                                                                             40.383                                                                             5.523                                                                              1.00                                                                              57.03                                        ATOM  4860                                                                              O   HOH                                                                               110                                                                               24.683                                                                             23.216                                                                             -3.359                                                                             1.00                                                                              47.03                                        ATOM  4861                                                                              O   HOH                                                                               111                                                                               27.878                                                                             49.199                                                                             -5.908                                                                             0.50                                                                              37.58                                        ATOM  4862                                                                              O   HOH                                                                               112                                                                               40.089                                                                             51.139                                                                             -3.822                                                                             0.50                                                                              28.49                                        ATOM  4863                                                                              O   HOH                                                                               113                                                                               1.194                                                                              48.031                                                                             17.761                                                                             0.50                                                                              31.30                                        ATOM  4864                                                                              O   HOH                                                                               114                                                                               15.911                                                                             47.963                                                                             -1.509                                                                             0.50                                                                              41.57                                        ATOM  4865                                                                              O   HOH                                                                               115                                                                               15.594                                                                             57.329                                                                             9.243                                                                              0.50                                                                              35.83                                        ATOM  4866                                                                              O   HOH                                                                               116                                                                               18.349                                                                             44.617                                                                             -4.211                                                                             0.50                                                                              25.42                                        ATOM  4867                                                                              O   HOH                                                                               117                                                                               33.773                                                                             56.268                                                                             5.129                                                                              1.00                                                                              50.98                                        ATOM  4868                                                                              O   HOH                                                                               118                                                                               42.261                                                                             50.708                                                                             2.854                                                                              0.50                                                                              23.17                                        ATOM  4869                                                                              O   HOH                                                                               119                                                                               31.149                                                                             49.232                                                                             23.790                                                                             1.00                                                                              48.45                                        ATOM  4870                                                                              O   HOH                                                                               120                                                                               47.467                                                                             26.554                                                                             -0.478                                                                             1.00                                                                              35.12                                        ATOM  4871                                                                              O   HOH                                                                               121                                                                               20.282                                                                             27.249                                                                             1.269                                                                              0.50                                                                              25.52                                        ATOM  4872                                                                              O   HOH                                                                               122                                                                               17.915                                                                             27.001                                                                             0.130                                                                              0.50                                                                              43.66                                        ATOM  4873                                                                              O   HOH                                                                               123                                                                               64.315                                                                             18.441                                                                             -9.136                                                                             0.50                                                                              50.91                                        ATOM  4874                                                                              O   HOH                                                                               124                                                                               51.346                                                                             15.323                                                                             -23.558                                                                            1.00                                                                              49.83                                        ATOM  4875                                                                              O   HOH                                                                               125                                                                               20.796                                                                             11.150                                                                             -11.607                                                                            0.50                                                                              30.99                                        ATOM  4876                                                                              O   HOH                                                                               126                                                                               52.824                                                                             44.504                                                                             12.282                                                                             0.50                                                                              32.83                                        ATOM  4877                                                                              O   HOH                                                                               127                                                                               53.398                                                                             41.694                                                                             12.905                                                                             1.00                                                                              48.52                                        ATOM  4878                                                                              O   HOH                                                                               128                                                                               20.223                                                                             5.133                                                                              20.272                                                                             0.50                                                                              29.69                                        ATOM  4879                                                                              O   HOH                                                                               129                                                                               27.206                                                                             1.320                                                                              21.447                                                                             1.00                                                                              27.19                                        ATOM  4880                                                                              O   HOH                                                                               130                                                                               24.082                                                                             11.809                                                                             20.686                                                                             1.00                                                                              40.93                                        ATOM  4881                                                                              O   HOH                                                                               131                                                                               23.900                                                                             10.267                                                                             17.824                                                                             1.00                                                                              50.50                                        ATOM  4882                                                                              O   HOH                                                                               132                                                                               28.117                                                                             5.220                                                                              10.701                                                                             0.50                                                                              25.36                                        ATOM  4883                                                                              O   HOH                                                                               133                                                                               31.375                                                                             10.930                                                                             3.919                                                                              1.00                                                                              33.16                                        ATOM  4884                                                                              O   HOH                                                                               134                                                                               43.293                                                                             29.293                                                                             19.633                                                                             1.00                                                                              26.02                                        ATOM  4885                                                                              O   HOH                                                                               135                                                                               47.906                                                                             33.111                                                                             9.169                                                                              1.00                                                                              37.21                                        ATOM  4886                                                                              O   HOH                                                                               136                                                                               52.105                                                                             14.532                                                                             4.067                                                                              1.00                                                                              12.30                                        ATOM  4887                                                                              O   HOH                                                                               137                                                                               59.327                                                                             14.609                                                                             8.309                                                                              1.00                                                                              27.43                                        ATOM  4888                                                                              O   HOH                                                                               138                                                                               61.489                                                                             16.241                                                                             7.756                                                                              1.00                                                                              36.45                                        ATOM  4889                                                                              O   HOH                                                                               139                                                                               59.814                                                                             12.113                                                                             -0.094                                                                             1.00                                                                              41.19                                        ATOM  4890                                                                              O   HOH                                                                               140                                                                               61.602                                                                             19.322                                                                             14.212                                                                             1.00                                                                              39.66                                        ATOM  4891                                                                              O   HOH                                                                               141                                                                               44.822                                                                             14.088                                                                             27.205                                                                             1.00                                                                              43.44                                        ATOM  4892                                                                              O   HOH                                                                               142                                                                               32.324                                                                             15.005                                                                             22.197                                                                             1.00                                                                              37.81                                        ATOM  4893                                                                              O   HOH                                                                               143                                                                               23.735                                                                             25.109                                                                             18.876                                                                             1.00                                                                              34.70                                        ATOM  4894                                                                              O   HOH                                                                               144                                                                               47.464                                                                             8.852                                                                              31.617                                                                             1.00                                                                              42.97                                        ATOM  4895                                                                              O   HOH                                                                               145                                                                               63.649                                                                             6.056                                                                              25.352                                                                             1.00                                                                              24.23                                        ATOM  4896                                                                              O   HOH                                                                               146                                                                               57.557                                                                             -8.767                                                                             13.297                                                                             1.00                                                                              54.16                                        ATOM  4897                                                                              O   HOH                                                                               147                                                                               65.381                                                                             -8.112                                                                             17.380                                                                             1.00                                                                              53.12                                        ATOM  4898                                                                              O   HOH                                                                               148                                                                               54.869                                                                             -3.233                                                                             3.058                                                                              1.00                                                                              20.55                                        ATOM  4899                                                                              O   HOH                                                                               149                                                                               50.284                                                                             2.436                                                                              7.783                                                                              1.00                                                                              21.77                                        ATOM  4900                                                                              O   HOH                                                                               150                                                                               40.450                                                                             4.556                                                                              1.629                                                                              1.00                                                                              36.03                                        ATOM  4901                                                                              O   HOH                                                                               151                                                                               38.315                                                                             4.435                                                                              -0.621                                                                             1.00                                                                              54.82                                        ATOM  4902                                                                              O   HOH                                                                               152                                                                               39.033                                                                             12.192                                                                             4.575                                                                              1.00                                                                              23.18                                        ATOM  4903                                                                              O   HOH                                                                               153                                                                               20.487                                                                             17.422                                                                             16.380                                                                             1.00                                                                              42.43                                        ATOM  4904                                                                              O   HOH                                                                               154                                                                               7.330                                                                              29.380                                                                             14.617                                                                             1.00                                                                              59.85                                        ATOM  4905                                                                              O   HOH                                                                               155                                                                               11.575                                                                             29.095                                                                             8.037                                                                              1.00                                                                              27.89                                        ATOM  4906                                                                              O   HOH                                                                               156                                                                               60.466                                                                             18.094                                                                             -3.688                                                                             1.00                                                                              39.21                                        ATOM  4907                                                                              O   HOH                                                                               157                                                                               34.227                                                                             30.218                                                                             -0.200                                                                             1.00                                                                              16.99                                        ATOM  4908                                                                              O   HOH                                                                               158                                                                               29.064                                                                             33.844                                                                             1.330                                                                              1.00                                                                              39.62                                        ATOM  4909                                                                              O   HOH                                                                               159                                                                               27.587                                                                             37.46                                                                              5.225                                                                              1.00                                                                              26.48                                        ATOM  4910                                                                              O   HOH                                                                               160                                                                               37.792                                                                             35.558                                                                             1.617                                                                              1.00                                                                              40.88                                        ATOM  4911                                                                              O   HOH                                                                               161                                                                               22.032                                                                             47.398                                                                             12.372                                                                             1.00                                                                              29.56                                        ATOM  4912                                                                              O   HOH                                                                               162                                                                               17.084                                                                             42.773                                                                             3.217                                                                              1.00                                                                              59.52                                        ATOM  4913                                                                              O   HOH                                                                               163                                                                               38.184                                                                             53.069                                                                             2.626                                                                              1.00                                                                              37.51                                        ATOM  4914                                                                              O   HOH                                                                               164                                                                               33.711                                                                             48.526                                                                             17.994                                                                             1.00                                                                              58.73                                        ATOM  4915                                                                              O   HOH                                                                               165                                                                               32.371                                                                             44.192                                                                             22.263                                                                             0.50                                                                              33.76                                        ATOM  4916                                                                              O   HOH                                                                               166                                                                               37.657                                                                             54.587                                                                             9.034                                                                              0.50                                                                              31.48                                        ATOM  4917                                                                              O   HOH                                                                               167                                                                               27.552                                                                             46.211                                                                             26.991                                                                             1.00                                                                              61.96                                        ATOM  4918                                                                              O   HOH                                                                               168                                                                               32.011                                                                             38.955                                                                             21.518                                                                             1.00                                                                              25.08                                        ATOM  4919                                                                              O   HOH                                                                               169                                                                               47.499                                                                             35.638                                                                             18.696                                                                             1.00                                                                              35.40                                        ATOM  4920                                                                              O   HOH                                                                               170                                                                               28.459                                                                             38.533                                                                             12.567                                                                             1.00                                                                              51.70                                        ATOM  4921                                                                              O   HOH                                                                               171                                                                               53.929                                                                             21.580                                                                             -6.399                                                                             1.00                                                                              24.95                                        ATOM  4922                                                                              O   HOH                                                                               172                                                                               26.651                                                                             18.234                                                                             -2.713                                                                             0.50                                                                              33.29                                        ATOM  4923                                                                              O   HOH                                                                               173                                                                               42.655                                                                             15.443                                                                             -1.278                                                                             1.00                                                                              30.29                                        ATOM  4924                                                                              O   HOH                                                                               174                                                                               45.560                                                                             26.974                                                                             -24.441                                                                            0.50                                                                              26.40                                        ATOM  4925                                                                              O   HOH                                                                               175                                                                               52.934                                                                             29.907                                                                             -19.523                                                                            0.50                                                                              32.71                                        ATOM  4926                                                                              O   HOH                                                                               176                                                                               26.381                                                                             16.979                                                                             -21.475                                                                            1.00                                                                              55.80                                        ATOM  4927                                                                              O   HOH                                                                               177                                                                               46.523                                                                             8.953                                                                              -25.135                                                                            1.00                                                                              55.70                                        ATOM  4928                                                                              O   HOH                                                                               178                                                                               41.397                                                                             7.159                                                                              -12.350                                                                            1.00                                                                              49.45                                        ATOM  4929                                                                              O   HOH                                                                               179                                                                               37.051                                                                             1.869                                                                              -16.152                                                                            0.50                                                                              22.12                                        ATOM  4930                                                                              O   HOH                                                                               180                                                                               48.915                                                                             13.423                                                                             -22.645                                                                            0.50                                                                              38.37                                        ATOM  4931                                                                              O   HOH                                                                               181                                                                               51.414                                                                             33.545                                                                             -13.567                                                                            1.00                                                                              27.21                                        ATOM  4932                                                                              O   HOH                                                                               182                                                                               40.136                                                                             20.409                                                                             14.870                                                                             1.00                                                                              50.68                                        ATOM  4933                                                                              O   HOH                                                                               183                                                                               27.368                                                                             20.586                                                                             29.572                                                                             0.50                                                                              22.75                                        ATOM  4934                                                                              O   HOH                                                                               184                                                                               33.144                                                                             15.340                                                                             33.325                                                                             0.50                                                                              34.27                                        ATOM  4935                                                                              O   HOH                                                                               185                                                                               41.866                                                                             10.270                                                                             32.855                                                                             0.50                                                                              27.94                                        ATOM  4936                                                                              O   HOH                                                                               186                                                                               36.169                                                                             7.373                                                                              38.507                                                                             0.50                                                                              28.46                                        ATOM  4937                                                                              O   HOH                                                                               187                                                                               65.230                                                                             13.163                                                                             12.508                                                                             0.50                                                                              29.96                                        ATOM  4938                                                                              O   HOH                                                                               188                                                                               69.243                                                                             -3.143                                                                             14.989                                                                             0.50                                                                              21.97                                        ATOM  4939                                                                              O   HOH                                                                               189                                                                               70.109                                                                             8.508                                                                              12.586                                                                             0.50                                                                              40.05                                        ATOM  4940                                                                              O   HOH                                                                               190                                                                               68.136                                                                             1.192                                                                              12.530                                                                             1.00                                                                              30.68                                        ATOM  4941                                                                              O   HOH                                                                               191                                                                               46.519                                                                             -1.841                                                                             24.920                                                                             1.00                                                                              51.89                                        ATOM  4942                                                                              O   HOH                                                                               192                                                                               35.512                                                                             0.276                                                                              23.742                                                                             1.00                                                                              58.13                                        ATOM  4943                                                                              O   HOH                                                                               193                                                                               27.272                                                                             4.449                                                                              13.576                                                                             1.00                                                                              41.45                                        ATOM  4944                                                                              O   HOH                                                                               194                                                                               20.663                                                                             4.047                                                                              27.178                                                                             0.50                                                                              42.21                                        ATOM  4945                                                                              O   HOH                                                                               195                                                                               62.540                                                                             2.570                                                                              8.192                                                                              1.00                                                                              35.49                                        ATOM  4946                                                                              O   HOH                                                                               196                                                                               56.134                                                                             -12.022                                                                            8.682                                                                              1.00                                                                              51.96                                        ATOM  4947                                                                              O   HOH                                                                               197                                                                               51.156                                                                             -5.845                                                                             11.368                                                                             1.00                                                                              38.51                                        ATOM  4948                                                                              O   HOH                                                                               198                                                                               47.936                                                                             -5.942                                                                             12.718                                                                             1.00                                                                              46.17                                        ATOM  4949                                                                              O   HOH                                                                               199                                                                               46.547                                                                             -7.383                                                                             10.304                                                                             1.00                                                                              42.53                                        ATOM  4950                                                                              O   HOH                                                                               200                                                                               31.686                                                                             4.036                                                                              10.011                                                                             0.50                                                                              39.93                                        ATOM  4951                                                                              O   HOH                                                                               201                                                                               18.345                                                                             18.429                                                                             18.069                                                                             1.00                                                                              52.41                                        ATOM  4952                                                                              O   HOH                                                                               202                                                                               8.319                                                                              32.684                                                                             12.203                                                                             1.00                                                                              58.05                                        ATOM  4953                                                                              O   HOH                                                                               203                                                                               30.148                                                                             26.964                                                                             7.489                                                                              0.50                                                                              17.11                                        ATOM  4954                                                                              O   HOH                                                                               204                                                                               30.520                                                                             29.659                                                                             18.757                                                                             1.00                                                                              41.82                                        ATOM  4955                                                                              O   HOH                                                                               205                                                                               41.389                                                                             15.889                                                                             1.196                                                                              1.00                                                                              41.86                                        ATOM  4956                                                                              O   HOH                                                                               206                                                                               59.747                                                                             12.116                                                                             -2.964                                                                             1.00                                                                              42.54                                        ATOM  4957                                                                              O   HOH                                                                               207                                                                               59.220                                                                             20.606                                                                             1.293                                                                              0.50                                                                              33.12                                        ATOM  4958                                                                              O   HOH                                                                               208                                                                               45.462                                                                             27.614                                                                             -3.993                                                                             1.00                                                                              53.13                                        ATOM  4959                                                                              O   HOH                                                                               209                                                                               8.977                                                                              42.303                                                                             22.785                                                                             0.50                                                                              28.98                                        ATOM  4960                                                                              O   HOH                                                                               210                                                                               7.375                                                                              36.792                                                                             15.794                                                                             0.50                                                                              25.08                                        ATOM  4961                                                                              O   HOH                                                                               211                                                                               20.262                                                                             31.233                                                                             -0.791                                                                             0.50                                                                              23.07                                        ATOM  4962                                                                              O   HOH                                                                               212                                                                               22.775                                                                             37.068                                                                             -1.456                                                                             0.50                                                                              26.21                                        ATOM  4963                                                                              O   HOH                                                                               213                                                                               31.515                                                                             33.290                                                                             -8.299                                                                             1.00                                                                              39.56                                        ATOM  4964                                                                              O   HOH                                                                               214                                                                               32.528                                                                             28.894                                                                             -2.045                                                                             0.50                                                                              30.57                                        ATOM  4965                                                                              O   HOH                                                                               215                                                                               23.556                                                                             52.964                                                                             -3.369                                                                             0.50                                                                              37.73                                        ATOM  4966                                                                              O   HOH                                                                               216                                                                               12.291                                                                             55.849                                                                             23.454                                                                             1.00                                                                              31.77                                        ATOM  4967                                                                              O   HOH                                                                               217                                                                               24.234                                                                             62.724                                                                             15.579                                                                             1.00                                                                              62.11                                        ATOM  4968                                                                              O   HOH                                                                               218                                                                               16.102                                                                             49.162                                                                             8.905                                                                              1.00                                                                              25.74                                        ATOM  4969                                                                              O   HOH                                                                               219                                                                               28.120                                                                             39.039                                                                             -4.114                                                                             1.00                                                                              29.56                                        ATOM  4970                                                                              O   HOH                                                                               220                                                                               44.251                                                                             45.804                                                                             -12.595                                                                            0.50                                                                              34.94                                        ATOM  4971                                                                              O   HOH                                                                               221                                                                               29.607                                                                             44.784                                                                             -10.015                                                                            1.00                                                                              60.29                                        ATOM  4972                                                                              O   HOH                                                                               222                                                                               25.270                                                                             58.721                                                                             8.796                                                                              1.00                                                                              53.22                                        ATOM  4973                                                                              O   HOH                                                                               223                                                                               34.170                                                                             56.320                                                                             7.918                                                                              1.00                                                                              50.34                                        ATOM  4974                                                                              O   HOH                                                                               224                                                                               35.135                                                                             51.082                                                                             -1.204                                                                             0.50                                                                              45.57                                        ATOM  4975                                                                              O   HOH                                                                               225                                                                               45.412                                                                             41.610                                                                             0.691                                                                              0.50                                                                              25.74                                        ATOM  4976                                                                              O   HOH                                                                               226                                                                               46.994                                                                             48.580                                                                             6.406                                                                              1.00                                                                              47.90                                        ATOM  4977                                                                              O   HOH                                                                               227                                                                               27.014                                                                             55.791                                                                             16.344                                                                             1.00                                                                              33.70                                        ATOM  4978                                                                              O   HOH                                                                               228                                                                               20.619                                                                             63.647                                                                             20.163                                                                             0.50                                                                              25.46                                        ATOM  4979                                                                              O   HOH                                                                               229                                                                               27.098                                                                             63.600                                                                             13.977                                                                             1.00                                                                              52.38                                        ATOM  4980                                                                              O   HOH                                                                               230                                                                               29.921                                                                             62.241                                                                             15.115                                                                             0.50                                                                              31.33                                        ATOM  4981                                                                              O   HOH                                                                               231                                                                               39.209                                                                             34.131                                                                             21.722                                                                             1.00                                                                              44.63                                        ATOM  4982                                                                              O   HOH                                                                               232                                                                               27.446                                                                             37.346                                                                             19.046                                                                             1.00                                                                              53.39                                        ATOM  4983                                                                              O   HOH                                                                               233                                                                               41.629                                                                             34.505                                                                             14.339                                                                             1.00                                                                              49.50                                        ATOM  4984                                                                              O   HOH                                                                               234                                                                               49.929                                                                             25.940                                                                             20.363                                                                             0.50                                                                              65.78                                        ATOM  4985                                                                              O   HOH                                                                               235                                                                               46.595                                                                             25.050                                                                             21.969                                                                             1.00                                                                              60.97                                        ATOM  4986                                                                              O   HOH                                                                               236                                                                               45.546                                                                             28.752                                                                             21.088                                                                             1.00                                                                              60.57                                        ATOM  4987                                                                              O   HOH                                                                               237                                                                               11.993                                                                             48.397                                                                             8.380                                                                              1.00                                                                              50.42                                        ATOM  4988                                                                              O   HOH                                                                               238                                                                               47.384                                                                             34.817                                                                             0.402                                                                              1.00                                                                              45.46                                        ATOM  4989                                                                              O   HOH                                                                               239                                                                               24.707                                                                             20.747                                                                             3.321                                                                              0.50                                                                              36.30                                        ATOM  4990                                                                              O   HOH                                                                               240                                                                               24.997                                                                             27.004                                                                             0.759                                                                              0.50                                                                              31.67                                        ATOM  4991                                                                              O   HOH                                                                               241                                                                               35.294                                                                             20.250                                                                             -2.672                                                                             1.00                                                                              55.67                                        ATOM  4992                                                                              O   HOH                                                                               242                                                                               25.636                                                                             12.744                                                                             -6.207                                                                             0.50                                                                              34.82                                        ATOM  4993                                                                              O   HOH                                                                               243                                                                               50.790                                                                             14.313                                                                             -15.411                                                                            1.00                                                                              40.65                                        ATOM  4994                                                                              O   HOH                                                                               244                                                                               60.682                                                                             29.709                                                                             -18.658                                                                            1.00                                                                              63.57                                        ATOM  4995                                                                              O   HOH                                                                               245                                                                               55.814                                                                             30.382                                                                             -22.340                                                                            0.50                                                                              42.64                                        ATOM  4996                                                                              O   HOH                                                                               246                                                                               35.354                                                                             4.428                                                                              -6.477                                                                             1.00                                                                              37.57                                        ATOM  4997                                                                              O   HOH                                                                               247                                                                               28.238                                                                             6.114                                                                              -2.367                                                                             1.00                                                                              50.71                                        ATOM  4998                                                                              O   HOH                                                                               248                                                                               55.861                                                                             14.928                                                                             -21.178                                                                            1.00                                                                              56.34                                        ATOM  4999                                                                              O   HOH                                                                               249                                                                               59.791                                                                             24.221                                                                             -18.460                                                                            1.00                                                                              49.24                                        ATOM  5000                                                                              O   HOH                                                                               250                                                                               28.695                                                                             10.159                                                                             -21.579                                                                            1.00                                                                              57.39                                        ATOM  5001                                                                              O   HOH                                                                               251                                                                               23.322                                                                             9.183                                                                              -18.681                                                                            0.50                                                                              36.90                                        END                                                                            8.2 CRYSTAL COORDINATES OF CRY3A                                               HEADER   TOXIN            22-JUN-94    1DLC        1DLC  2                     COMPND   DELTA-ENDOTOXIN CRYIIIA (BT13)            1DLC  3                     SOURCE   (BACILLUS THURINGIENSIS, SUBSPECIES TENEBRIONIS)                                                                         1DLC  4                     AUTHOR   J. LI                                     1DLC  5                     REVDAT                                                                               1  30-SEP-94 1DLC  0                         1DLC  6                     REMARK                                                                               1                                            1DLC  7                     REMARK                                                                               1  REFERENCE 1                               1DLC  8                     REMARK                                                                               1  AUTH                                                                               J. LI, J. CARROLL, D. J. ELLAR        1DLC  9                     REMARK                                                                               1  TITL                                                                               CRYSTAL STRUCTURE OF INSECTICIDAL DELTA-ENDOTOXIN                                                                    1DLC 10                     REMARK                                                                               1  TITL 2                                                                             FROM BACILLUS THURINGIENSIS AT 2.5 ANGSTROMS                                                                         1DLC 11                     REMARK                                                                               1  TITL 3                                                                             RESOLUTION                            1DLC 12                     REMARK                                                                               1  REF NATURE    V. 353  815 1991            1DLC 13                     REMARK                                                                               1  REFN                                                                               ASTM NATUAS UK ISSN 0028-0836     0006                                                                               1DLC 14                     REMARK                                                                               1  REFERENCE 2                               1DLC 15                     REMARK                                                                               1  AUTH                                                                               J. LI, R. HENDERSON, J. CARROLL, D. ELLAR                                                                            1DLC 16                     REMARK                                                                               1  TITL                                                                               X-RAY ANALYSIS OF THE CRYSTALLINE PARASPORAL                                                                         1DLC 17                     REMARK                                                                               1  TITL 2                                                                             INCLUSION IN BACILLUS THURINGIENSIS VAR.                                                                             1DLC 18                     REMARK                                                                               1  TITL 3                                                                             TENEBRIONIS                           1DLC 19                     REMARK                                                                               1  REF J. MOL. BIOL.     V. 199 543 1988     1DLC 20                     REMARK                                                                               1  REFN                                                                               ASTM JMOBAK UK ISSN 0022-2836    0070 1DLC 21                     REMARK                                                                               2                                            1DLC 22                     REMARK                                                                               2  RESOLUTION. 2.5 ANGSTROMS.                1DLC 23                     REMARK                                                                               3                                            1DLC 24                     REMARK                                                                               3  REFINEMENT.                               1DLC 25                     REMARK                                                                               3  PROGRAM         X-PLOR                    1DLC 26                     REMARK                                                                               3  AUTHORS         BRUNGER                   1DLC 27                     REMARK                                                                               3  R VALUE         0.183                     1DLC 28                     REMARK                                                                               3  RMSD BOND DISTANCES                                                                            0.011 ANGSTROMS           1DLC 29                     REMARK                                                                               3  RMSD BOND ANGLES                                                                               1.58 DEGREES              1DLC 30                     REMARK                                                                               3  RMSD DIHEDRAL ANGLES                                                                           25.06 DEGREES             1DLC 31                     REMARK                                                                               3  RMSD IMPROPER ROTATION                                                                         1.471 DEGREES             1DLC 32                     REMARK                                                                               3                                            1DLC 33                     REMARK                                                                               3  NUMBER OF REFLECTIONS                                                                          27726                     1DLC 34                     REMARK                                                                               3  RESOLUTION RANGE                                                                               16.0-2.5 ANGSTROMS        1DLC 35                     REMARK                                                                               3  DATA CUTOFF     0.0 SIGMA(F)              1DLC 36                     REMARK                                                                               3  PERCENT COMPLETION                                                                             100.                      1DLC 37                     REMARK                                                                               3                                            1DLC 38                     REMARK                                                                               3  NUMBER OF PROTEIN ATOMS                                                                        4697                      1DLC 39                     REMARK                                                                               3  NUMBER OF SOLVENT ATOMS                                                                        106                       1DLC 40                     REMARK                                                                               3                                            1DLC 41                     REMARK                                                                               3  THE ATOMIC MODEL INCLUDES RESIDUES 61-644 OF THE                                                                         1DLC 42                     REMARK                                                                               3  AND 106 BOUND WATER MOLECULES. BULK SOLVENT CONTRIBUTION                                                                 1DLC 43                     REMARK                                                                               3  TO THE STRUCTURE FACTOR WAS CALCULATED USING THE                                                                         1DLC 44                     REMARK                                                                               3  PROGRAM SFALL AND INCLUDED IN THIS REFINEMENT.                                                                           1DLC 45                     REMARK                                                                               3                                            1DLC 46                     REMARK                                                                               4                                            1DLC 47                     REMARK                                                                               4  CRYIIIA BELONGS TO THE "1CRY" FAMILY OF DELTA-ENDOTOXINS,                                                                1DLC 48                     REMARK                                                                               4  WHICH ARE PORE-FORMING INSECTICIDAL PROTEIN TOXINS                                                                       1DLC 49                     REMARK                                                                               4  CONTAINED IN THE CRYSTALLINE PARASPORAL INCLUSIONS                                                                       1DLC 50                     REMARK                                                                               4  BACILLUS THURINGIENSIS. THE SUBCLASS III IS TOXIC                                                                        1DLC 51                     REMARK                                                                               4  SPECIFICALLY TO COLEOPTERAN INSECTS, I.E., BEETLES.                                                                      1DLC 52                     REMARK                                                                               4  FUNCTION BY BINDING TO MIDGUT EPITHELIAL CELLS AND                                                                       1DLC 53                     REMARK                                                                               4  COLLOIDOSMOTIC LYSIS.                     1DLC 54                     REMARK                                                                               5                                            1DLC SS                     REMARK                                                                               5  THE SEQUENCE OF CRYIIIA IN THE ATOMIC MODEL IS TAKEN                                                                     1DLC 56                     REMARK                                                                               5  HOEFTE, H., SEURINCK, J., VAN HOUTVEN, A. AND VAECK,                                                                     1DLC 57                     REMARK                                                                               5  (1987) NUCLEIC ACIDS RES. 15:7183. EMBL ACCESSION                                                                        1DLC 58                     REMARK                                                                               5  P07130, ENTRY NAME CR70.sub.-- BACTT. RESIDUES 1-57                                                                      1DLC 59                     REMARK                                                                               5  REMOVED IN THE MATURE TOXIN. RESIDUES 58-60 ARE                                                                          1DLC 60                     REMARK                                                                               5  INVISIBLE IN THE CRYSTAL STRUCTURE.       1DLC 61                     REMARK                                                                               6                                            1DLC 62                     REMARK                                                                               6  THE STRUCTURE WAS REPORTED IN PAPER [1] ABOVE AFTER                                                                      1DLC 63                     REMARK                                                                               6  PRELIMIMARY REFINEMENT. THE COORDINATES BEING DEPOSITED                                                                  1DLC 64                     REMARK                                                                               6  HERE RESULTED FROM FURTHER REFINEMENT.    1DLC 65                     REMARK                                                                               7                                            1DLC 66                     REMARK                                                                               7  CROSS REFERENCE TO SEQUENCE DATABASE      1DLC 67                     REMARK                                                                               7  SWISS-PROT ENTRY NAME   PDB ENTRY CHAIN NAME                                                                             1DLC 68                     REMARK                                                                               7  CR70.sub.-- BACTT                         1DLC 69                     SEQRES                                                                               1  584                                                                               THR                                                                               THR                                                                               LYS                                                                               ASP                                                                               VAL                                                                               ILE                                                                               GLN                                                                               LYS                                                                               GLY                                                                               ILE                                                                               SER                                                                               VAL                                                                               VAL                                                                               1DLC 70                     SEQRES                                                                               2  584                                                                               GLY                                                                               ASP                                                                               LEU                                                                               LEU                                                                               GLY                                                                               VAL                                                                               VAL                                                                               GLY                                                                               PHE                                                                               PRO                                                                               PHE                                                                               GLY                                                                               GLY                                                                               1DLC 71                     SEQRES                                                                               3  584                                                                               ALA                                                                               LEU                                                                               VAL                                                                               SER                                                                               PHE                                                                               TYR                                                                               THR                                                                               ASN                                                                               PHE                                                                               LEU                                                                               ASN                                                                               THR                                                                               ILE                                                                               1DLC 72                     SEQRES                                                                               4  584                                                                               TRP                                                                               PRO                                                                               SER                                                                               GLU                                                                               ASP                                                                               PRO                                                                               TRP                                                                               LYS                                                                               ALA                                                                               PHE                                                                               MET                                                                               GLU                                                                               GLN                                                                               1DLC 73                     SEQRES                                                                               5  584                                                                               VAL                                                                               GLU                                                                               ALA                                                                               LEU                                                                               MET                                                                               ASP                                                                               GLN                                                                               LYS                                                                               ILE                                                                               ALA                                                                               ASP                                                                               TYR                                                                               ALA                                                                               1DLC 74                     SEQRES                                                                               6  584                                                                               LYS                                                                               ASN                                                                               LYS                                                                               ALA                                                                               LEU                                                                               ALA                                                                               GLU                                                                               LEU                                                                               GLN                                                                               GLY                                                                               LEU                                                                               GLN                                                                               ASN                                                                               1DLC 75                     SEQRES                                                                               7  584                                                                               ASN                                                                               VAL                                                                               GLU                                                                               ASP                                                                               TYR                                                                               VAL                                                                               SER                                                                               ALA                                                                               LEU                                                                               SER                                                                               SER                                                                               TRP                                                                               GLN                                                                               1DLC 76                     SEQRES                                                                               8  584                                                                               LYS                                                                               ASN                                                                               PRO                                                                               VAL                                                                               SER                                                                               SER                                                                               ARG                                                                               ASN                                                                               PRO                                                                               HIS                                                                               SER                                                                               GLN                                                                               GLY                                                                               1DLC 77                     SEQRES                                                                               9  584                                                                               ARG                                                                               ILE                                                                               ARG                                                                               GLU                                                                               LEU                                                                               PHE                                                                               SER                                                                               GLN                                                                               ALA                                                                               GLU                                                                               SER                                                                               HIS                                                                               PHE                                                                               1DLC 78                     SEQRES                                                                               10 584                                                                               ARG                                                                               ASN                                                                               SER                                                                               MET                                                                               PRO                                                                               SER                                                                               PHE                                                                               ALA                                                                               ILE                                                                               SER                                                                               GLY                                                                               TYR                                                                               GLU                                                                               1DLC 79                     SEQRES                                                                               11 584                                                                               VAL                                                                               LEU                                                                               PHE                                                                               LEU                                                                               THR                                                                               THR                                                                               TYR                                                                               ALA                                                                               GLN                                                                               ALA                                                                               ALA                                                                               ASN                                                                               THR                                                                               1DLC 80                     SEQRES                                                                               12 584                                                                               HIS                                                                               LEU                                                                               PHE                                                                               LEU                                                                               LEU                                                                               LYS                                                                               ASP                                                                               ALA                                                                               GLN                                                                               ILE                                                                               TYR                                                                               GLY                                                                               GLU                                                                               1DLC 81                     SEQRES                                                                               13 584                                                                               GLU                                                                               TRP                                                                               GLY                                                                               TYR                                                                               GLU                                                                               LYS                                                                               GLU                                                                               ASP                                                                               ILE                                                                               ALA                                                                               GLU                                                                               PHE                                                                               TYR                                                                               1DLC 82                     SEQRES                                                                               14 584                                                                               LYS                                                                               ARG                                                                               GLN                                                                               LEU                                                                               LYS                                                                               LEU                                                                               THR                                                                               GLN                                                                               GLU                                                                               TYR                                                                               THR                                                                               ASP                                                                               HIS                                                                               1DLC 83                     SEQRES                                                                               15 584                                                                               CYS                                                                               VAL                                                                               LYS                                                                               TRP                                                                               TYR                                                                               ASN                                                                               VAL                                                                               GLY                                                                               LEU                                                                               ASP                                                                               LYS                                                                               LEU                                                                               ARG                                                                               1DLC 84                     SEQRES                                                                               16 584                                                                               GLY                                                                               SER                                                                               SER                                                                               TYR                                                                               GLU                                                                               SER                                                                               TRP                                                                               VAL                                                                               ASN                                                                               PHE                                                                               ASN                                                                               ARG                                                                               TYR                                                                               1DLC 85                     SEQRES                                                                               17 584                                                                               ARG                                                                               ARG                                                                               GLU                                                                               MET                                                                               THR                                                                               LEU                                                                               THR                                                                               VAL                                                                               LEU                                                                               ASP                                                                               LEU                                                                               ILE                                                                               ALA                                                                               1DLC 86                     SEQRES                                                                               18 584                                                                               LEU                                                                               PHE                                                                               PRO                                                                               LEU                                                                               TYR                                                                               ASP                                                                               VAL                                                                               ARG                                                                               LEU                                                                               TYR                                                                               PRD                                                                               LYS                                                                               GLU                                                                               1DLC 87                     SEQRES                                                                               19 584                                                                               VAL                                                                               LYS                                                                               THR                                                                               GLU                                                                               LEU                                                                               THR                                                                               ARG                                                                               ASP                                                                               VAL                                                                               LEU                                                                               THR                                                                               ASP                                                                               PRO                                                                               1DLC 88                     SEQRES                                                                               20 584                                                                               ILE                                                                               VAL                                                                               GLY                                                                               VAL                                                                               ASN                                                                               ASN                                                                               LEU                                                                               ARG                                                                               GLY                                                                               TYR                                                                               GLY                                                                               THR                                                                               THR                                                                               1DLC 89                     SEQRES                                                                               21 584                                                                               PHE                                                                               SER                                                                               ASN                                                                               ILE                                                                               GLU                                                                               ASN                                                                               TYR                                                                               ILE                                                                               ARG                                                                               LYS                                                                               PRO                                                                               HIS                                                                               LEU                                                                               1DLC 90                     SEQRES                                                                               22 584                                                                               PHE                                                                               ASP                                                                               TYR                                                                               LEU                                                                               HIS                                                                               ARG                                                                               ILE                                                                               GLN                                                                               PHE                                                                               HIS                                                                               THR                                                                               ARG                                                                               PHE                                                                               1DLC 91                     SEQRES                                                                               23 584                                                                               GLN                                                                               PRO                                                                               GLY                                                                               TYR                                                                               TYR                                                                               GLY                                                                               ASN                                                                               ASP                                                                               SER                                                                               PHE                                                                               ASN                                                                               TYR                                                                               TRP                                                                               1DLC 92                     SEQRES                                                                               24 584                                                                               SER                                                                               GLY                                                                               ASN                                                                               TYR                                                                               VAL                                                                               SER                                                                               THR                                                                               ARG                                                                               PRO                                                                               SER                                                                               ILE                                                                               GLY                                                                               SER                                                                               1DLC 93                     SEQRES                                                                               25 584                                                                               ASN                                                                               ASP                                                                               ILE                                                                               ILE                                                                               THR                                                                               SER                                                                               PRO                                                                               PHE                                                                               TYR                                                                               GLY                                                                               ASN                                                                               LYS                                                                               SER                                                                               1DLC 94                     SEQRES                                                                               26 584                                                                               SER                                                                               GLU                                                                               PRO                                                                               VAL                                                                               GLN                                                                               ASN                                                                               LEU                                                                               GLU                                                                               PHE                                                                               ASN                                                                               GLY                                                                               GLU                                                                               LYS                                                                               1DLC 95                     SEQRES                                                                               27 584                                                                               VAL                                                                               TYR                                                                               ARG                                                                               ALA                                                                               VAL                                                                               ALA                                                                               ASN                                                                               THR                                                                               ASN                                                                               LEU                                                                               ALA                                                                               VAL                                                                               TRP                                                                               1DLC 96                     SEQRES                                                                               28 584                                                                               PRO                                                                               SER                                                                               ALA                                                                               VAL                                                                               TYR                                                                               SER                                                                               GLY                                                                               VAL                                                                               THR                                                                               LYS                                                                               VAL                                                                               GLU                                                                               PHE                                                                               1DLC 97                     SEQRES                                                                               29 584                                                                               SER                                                                               GLN                                                                               TYR                                                                               ASN                                                                               ASP                                                                               GLN                                                                               THR                                                                               ASP                                                                               GLU                                                                               ALA                                                                               SER                                                                               THR                                                                               GLN                                                                               1DLC 98                     SEQRES                                                                               30 584                                                                               THR                                                                               TYR                                                                               ASP                                                                               SER                                                                               LYS                                                                               ARG                                                                               ASN                                                                               VAL                                                                               GLY                                                                               ALA                                                                               VAL                                                                               SER                                                                               TRP                                                                               1DLC 99                     SEQRES                                                                               31 584                                                                               ASP                                                                               SER                                                                               ILE                                                                               ASP                                                                               GLN                                                                               LEU                                                                               PRO                                                                               PRO                                                                               GLU                                                                               THR                                                                               THR                                                                               ASP                                                                               GLU                                                                               1DLC 100                    SEQRES                                                                               32 584                                                                               PRO                                                                               LEU                                                                               GLU                                                                               LYS                                                                               GLY                                                                               TYR                                                                               SER                                                                               HIS                                                                               GLN                                                                               LEU                                                                               ASN                                                                               TYR                                                                               VAL                                                                               1DLC 101                    SEQRES                                                                               33 584                                                                               MET                                                                               CYS                                                                               PHE                                                                               LEU                                                                               MET                                                                               GLN                                                                               GLY                                                                               SER                                                                               ARG                                                                               GLY                                                                               THR                                                                               ILE                                                                               PRO                                                                               1DLC 102                    SEQRES                                                                               34 584                                                                               VAL                                                                               LEU                                                                               THR                                                                               TRP                                                                               THR                                                                               HIS                                                                               LYS                                                                               SER                                                                               VAL                                                                               ASP                                                                               PHE                                                                               PHE                                                                               ASN                                                                               1DLC 103                    SEQRES                                                                               35 584                                                                               MET                                                                               ILE                                                                               ASP                                                                               SER                                                                               LYS                                                                               LYS                                                                               ILE                                                                               THR                                                                               GLN                                                                               LEU                                                                               PRO                                                                               LEU                                                                               VAL                                                                               1DLC 104                    SEQRES                                                                               36 584                                                                               LYS                                                                               ALA                                                                               TYR                                                                               LYS                                                                               LEU                                                                               GLN                                                                               SER                                                                               GLY                                                                               ALA                                                                               SER                                                                               VAL                                                                               VAL                                                                               ALA                                                                               1DLC 105                    SEQRES                                                                               37 584                                                                               GLY                                                                               PRO                                                                               ARG                                                                               PHE                                                                               THR                                                                               GLY                                                                               GLY                                                                               ASP                                                                               ILE                                                                               ILE                                                                               GLN                                                                               CYS                                                                               THR                                                                               1DLC 106                    SEQRES                                                                               38 584                                                                               GLU                                                                               ASN                                                                               GLY                                                                               SER                                                                               ALA                                                                               ALA                                                                               THR                                                                               ILE                                                                               TYR                                                                               VAL                                                                               THR                                                                               PRO                                                                               ASP                                                                               1DLC 107                    SEQRES                                                                               39 584                                                                               VAL                                                                               SER                                                                               TYR                                                                               SER                                                                               GLN                                                                               LYS                                                                               TYR                                                                               ARG                                                                               ALA                                                                               ARG                                                                               ILE                                                                               HIS                                                                               TYR                                                                               1DLC 108                    SEQRES                                                                               40 584                                                                               ALA                                                                               SER                                                                               THR                                                                               SER                                                                               GLN                                                                               ILE                                                                               THR                                                                               PHE                                                                               THR                                                                               LEU                                                                               SER                                                                               LEU                                                                               ASP                                                                               1DLC 109                    SEQRES                                                                               41 584                                                                               GLY                                                                               ALA                                                                               PRO                                                                               PHE                                                                               ASN                                                                               GLN                                                                               TYR                                                                               TYR                                                                               PHE                                                                               ASP                                                                               LYS                                                                               THR                                                                               ILE                                                                               1DLC 110                    SEQRES                                                                               42 584                                                                               ASN                                                                               LYS                                                                               GLY                                                                               ASP                                                                               THR                                                                               LEU                                                                               THR                                                                               TYR                                                                               ASN                                                                               SER                                                                               PHE                                                                               ASN                                                                               LEU                                                                               1DLC 111                    SEQRES                                                                               43 584                                                                               ALA                                                                               SER                                                                               PHE                                                                               SER                                                                               THR                                                                               PRO                                                                               PHE                                                                               GLU                                                                               LEU                                                                               SER                                                                               GLY                                                                               ASN                                                                               ASN                                                                               1DLC 112                    SEQRES                                                                               44 584                                                                               LEU                                                                               GLN                                                                               ILE                                                                               GLY                                                                               VAL                                                                               THR                                                                               GLY                                                                               LEU                                                                               SER                                                                               ALA                                                                               GLY                                                                               ASP                                                                               LYS                                                                               1DLC 113                    SEQRES                                                                               45 584                                                                               VAL                                                                               TYR                                                                               ILE                                                                               ASP                                                                               LYS                                                                               ILE                                                                               GLU                                                                               PHE                                                                               ILE                                                                               PRO                                                                               VAL                                                                               ASN   1DLC 114                    FTNOTE                                                                               1                                            1DLC 115                    FTNOTE                                                                               1  RESIDUE ARG 443 IS MODELED IN TWO CONFORMATIONS.                                                                         1DLC 116                    FORMUL                                                                               2  HOH  *106(H2 O1)                          1DLC 117                    CRYST1                                                                               117.090                                                                            134.260                                                                            104.500                                                                            90.00                                                                             90.00                                                                             90.00                                                                             C 2 2 21   8            1DLC 118                    ORIGX1                                                                               1.000000                                                                            0.000000                                                                            0.000000                                                                            0.00000                       1DLC 119                    ORIGX2                                                                               0.000000                                                                            1.000000                                                                            0.000000                                                                            0.00000                       1DLC 120                    ORIGX3                                                                               0.000000                                                                            0.000000                                                                            1.000000                                                                            0.00000                       1DLC 121                    SCALE1                                                                               0.008540                                                                            0.000000                                                                            0.000000                                                                            0.00000                       1DLC 122                    SCALE2                                                                               0.000000                                                                            0.007448                                                                            0.000000                                                                            0.00000                       1DLC 123                    SCALE3                                                                               0.000000                                                                            0.000000                                                                            0.009569                                                                            0.00000                       1DLC 124                    ATOM  1  N  THR 61 29.687                                                                             34.216                                                                             28.976                                                                             1.00                                                                              81.05            1DLC 125                    ATOM  2  CA THR 61 29.891                                                                             35.382                                                                             28.051                                                                             1.00                                                                              79.92            1DLC 126                    ATOM  3  C  THR 61 30.511                                                                             36.562                                                                             28.809                                                                             1.00                                                                              78.01            1DLC 127                    ATOM  4  O  THR 61 30.542                                                                             36.553                                                                             30.039                                                                             1.00                                                                              78.99            1DLC 128                    ATOM  5  CB THR 61 28.566                                                                             35.808                                                                             27.359                                                                             1.00                                                                              81.30            1DLC 129                    ATOM  6  OG1                                                                               THR 61 28.815                                                                             36.906                                                                             26.470                                                                             1.00                                                                              81.70            1DLC 130                    ATOM  7  CG2                                                                               THR 61 27.514                                                                             36.206                                                                             28.388                                                                             1.00                                                                              82.00            1DLC 131                    ATOM  8  N  THR 62 31.035                                                                             37.542                                                                             28.074                                                                             1.00                                                                              74.62            1DLC 132                    ATOM  9  CA THR 62 31.689                                                                             38.735                                                                             28.648                                                                             1.00                                                                              71.74            1DLC 133                    ATOM  10 C  THR 62 32.886                                                                             38.447                                                                             29.565                                                                             1.00                                                                              68.69            1DLC 134                    ATOM  11 O  THR 62 33.402                                                                             39.348                                                                             30.227                                                                             1.00                                                                              67.78            1DLC 135                    ATOM  12 CB THR 62 30.702                                                                             39.676                                                                             29.416                                                                             1.00                                                                              72.26            1DLC 136                    ATOM  13 OG1                                                                               THR 62 30.353                                                                             39.108                                                                             30.689                                                                             1.00                                                                              70.81            1DLC 137                    ATOM  14 CG2                                                                               THR 62 29.446                                                                             39.935                                                                             28.595                                                                             1.00                                                                              72.45            1DLC 138                    ATOM  15 N  LYS 63 33.367                                                                             37.206                                                                             29.542                                                                             1.00                                                                              65.97            1DLC 139                    ATOM  16 CA LYS 63 34.505                                                                             36.792                                                                             30.369                                                                             1.00                                                                              64.35            1DLC 140                    ATOM  17 C  LYS 63 35.716                                                                             37.704                                                                             30.142                                                                             1.00                                                                              60.39            1DLC 141                    ATOM  18 O  LYS 63 36.514                                                                             37.928                                                                             31.050                                                                             1.00                                                                              58.79            1DLC 142                    ATOM  19 CB LYS 63 34.903                                                                             35.327                                                                             30.097                                                                             1.00                                                                              67.19            1DLC 143                    ATOM  20 CG LYS 63 33.799                                                                             34.413                                                                             29.553                                                                             1.00                                                                              71.54            1DLC 144                    ATOM  21 CD LYS 63 33.671                                                                             34.566                                                                             28.032                                                                             1.00                                                                              77.47            1DLC 145                    ATOM  22 CE LYS 63 32.583                                                                             33.671                                                                             27.434                                                                             1.00                                                                              79.28            1DLC 146                    ATOM  23 NZ LYS 63 32.253                                                                             34.062                                                                             26.018                                                                             1.00                                                                              79.70            1DLC 147                    ATOM  24 N  ASP 64 35.829                                                                             38.242                                                                             28.928                                                                             1.00                                                                              56.53            1DLC 148                    ATOM  25 CA ASP 64 36.919                                                                             39.146                                                                             28.568                                                                             1.00                                                                              52.15            1DLC 149                    ATOM  26 C  ASP 64 37.009                                                                             40.333                                                                             29.526                                                                             1.00                                                                              46.41            1DLC 150                    ATOM  27 O  ASP 64 38.033                                                                             40.514                                                                             30.176                                                                             1.00                                                                              45.73            1DLC 151                    ATOM  28 CB ASP 64 36.747                                                                             39.647                                                                             27.131                                                                             1.00                                                                              59.48            1DLC 152                    ATOM  29 CG ASP 64 37.811                                                                             40.666                                                                             26.729                                                                             1.00                                                                              66.90            1DLC 153                    ATOM  30 OD1                                                                               ASP 64 39.020                                                                             40.354                                                                             26.864                                                                             1.00                                                                              70.25            1DLC 154                    ATOM  31 OD2                                                                               ASP 64 37.436                                                                             41.780                                                                             26.280                                                                             1.00                                                                              70.28            1DLC 155                    ATOM  32 N  VAL 65 35.937                                                                             41.120                                                                             29.631                                                                             1.00                                                                              40.49            1DLC 156                    ATOM  33 CA VAL 65 35.929                                                                             42.276                                                                             30.535                                                                             1.00                                                                              36.43            1DLC 157                    ATOM  34 C  VAL 65 35.981                                                                             41.865                                                                             31.998                                                                             1.00                                                                              33.19            1DLC 158                    ATOM  35 O  VAL 65 36.481                                                                             42.612                                                                             32.843                                                                             1.00                                                                              33.95            1DLC 159                    ATOM  36 CB VAL 65 34.721                                                                             43.233                                                                             30.319                                                                             1.00                                                                              34.54            1DLC 160                    ATOM  37 CG1                                                                               VAL 65 34.823                                                                             43.903                                                                             28.969                                                                             1.00                                                                              35.83            1DLC 161                    ATOM  38 CG2                                                                               VAL 65 33.405                                                                             42.501                                                                             30.473                                                                             1.00                                                                              36.36            1DLC 162                    ATOM  39 N  ILE 66 35.474                                                                             40.676                                                                             32.299                                                                             1.00                                                                              28.34            1DLC 163                    ATOM  40 CA ILE 66 35.506                                                                             40.187                                                                             33.666                                                                             1.00                                                                              26.84            1DLC 164                    ATOM  41 C  ILE 66 36.953                                                                             39.854                                                                             34.029                                                                             1.00                                                                              27.43            1DLC 165                    ATOM  42 O  ILE 66 37.405                                                                             40.153                                                                             35.138                                                                             1.00                                                                              27.70            1DLC 166                    ATOM  43 CB ILE 66 34.576                                                                             38.962                                                                             33.857                                                                             1.00                                                                              26.34            1DLC 167                    ATOM  44 CG1                                                                               ILE 66 33.138                                                                             39.362                                                                             33.533                                                                             1.00                                                                              26.70            1DLC 168                    ATOM  45 CG2                                                                               ILE 66 34.627                                                                             38.459                                                                             35.299                                                                             1.00                                                                              23.41            1DLC 169                    ATOM  46 CD1                                                                               ILE 66 32.625                                                                             40.529                                                                             34.377                                                                             1.00                                                                              27.75            1DLC 170                    ATOM  47 N  GLN 67 37.696                                                                             39.313                                                                             33.063                                                                             1.00                                                                              26.53            1DLC 171                    ATOM  48 CA GLN 67 39.100                                                                             38.962                                                                             33.278                                                                             1.00                                                                              27.75            1DLC 172                    ATOM  49 C  GLN 67 39.931                                                                             40.231                                                                             33.442                                                                             1.00                                                                              25.84            1DLC 173                    ATOM  50 O  GLN 67 40.772                                                                             40.315                                                                             34.340                                                                             1.00                                                                              23.91            1DLC 174                    ATOM  51 CB GLN 67 39.639                                                                             38.122                                                                             32.122                                                                             1.00                                                                              32.89            1DLC 175                    ATOM  52 CG GLN 67 40.360                                                                             36.852                                                                             32.576                                                                             1.00                                                                              39.52            1DLC 176                    ATOM  53 CD GLN 67 41.866                                                                             37.006                                                                             32.729                                                                             1.00                                                                              44.36            1DLC 177                    ATOM  54 OE1                                                                               GLN 67 42.613                                                                             36.080                                                                             32.442                                                                             1.00                                                                              52.02            1DLC 178                    ATOM  55 NE2                                                                               GLN 67 42.316                                                                             38.156                                                                             33.188                                                                             1.00                                                                              45.86            1DLC 179                    ATOM  56 N  LYS 68 39.688                                                                             41.216                                                                             32.580                                                                             1.00                                                                              22.97            1DLC 180                    ATOM  57 CA LYS 68 40.388                                                                             42.496                                                                             32.664                                                                             1.00                                                                              24.69            1DLC 181                    ATOM  58 C  LYS 68 40.100                                                                             43.123                                                                             34.030                                                                             1.00                                                                              24.93            1DLC 182                    ATOM  59 O  LYS 68 41.010                                                                             43.577                                                                             34.725                                                                             1.00                                                                              28.51            1DLC 183                    ATOM  60 CB LYS 68 39.926                                                                             43.436                                                                             31.550                                                                             1.00                                                                              26.18            1DLC 184                    ATOM  61 CG LYS 68 40.265                                                                             42.946                                                                             30.158                                                                             1.00                                                                              29.43            1DLC 185                    ATOM  62 CD LYS 68 39.812                                                                             43.936                                                                             29.098                                                                             1.00                                                                              35.76            1DLC 186                    ATOM  63 CE LYS 68 40.187                                                                             43.453                                                                             27.710                                                                             1.00                                                                              37.35            1DLC 187                    ATOM  64 NZ LYS 68 41.635                                                                             43.087                                                                             27.651                                                                             1.00                                                                              43.99            1DLC 188                    ATOM  65 N  GLY 69 38.832                                                                             43.092                                                                             34.431                                                                             1.00                                                                              24.56            1DLC 189                    ATOM  66 CA GLY 69 38.443                                                                             43.632                                                                             35.717                                                                             1.00                                                                              22.62            1DLC 190                    ATOM  67 C  GLY 69 39.161                                                                             42.937                                                                             36.859                                                                             1.00                                                                              22.36            1DLC 191                    ATOM  68 O  GLY 69 39.750                                                                             43.599                                                                             37.709                                                                             1.00                                                                              25.64            1DLC 192                    ATOM  69 N  ILE 70 39.144                                                                             41.606                                                                             36.862                                                                             1.00                                                                              20.46            1DLC 193                    ATOM  70 CA ILE 70 39.801                                                                             40.821                                                                             37.908                                                                             1.00                                                                              19.46            1DLC 194                    ATOM  71 C  ILE 70 41.318                                                                             41.037                                                                             37.943                                                                             1.00                                                                              21.56            1DLC 195                    ATOM  72 O  ILE 70 41.911                                                                             41.211                                                                             39.015                                                                             1.00                                                                              20.57            1DLC 196                    ATOM  73 CB ILE 70 39.452                                                                             39.303                                                                             37.773                                                                             1.00                                                                              21.33            1DLC 197                    ATOM  74 CG1                                                                               ILE 70 37.984                                                                             39.074                                                                             38.191                                                                             1.00                                                                              21.90            1DLC 198                    ATOM  75 CG2                                                                               ILE 70 40.413                                                                             38.437                                                                             38.609                                                                             1.00                                                                              17.07            1DLC 199                    ATOM  76 CD1                                                                               ILE 70 37.517                                                                             37.621                                                                             38.227                                                                             1.00                                                                              15.87            1DLC 200                    ATOM  77 N  SER 71 41.929                                                                             41.072                                                                             36.763                                                                             1.00                                                                              22.90            1DLC 201                    ATOM  78 CA SER 71 43.371                                                                             41.277                                                                             36.627                                                                             1.00                                                                              24.32            1DLC 202                    ATOM  79 C  SER 71 43.861                                                                             42.628                                                                             37.141                                                                             1.00                                                                              23.60            1DLC 203                    ATOM  80 O  SER 71 44.873                                                                             42.697                                                                             37.845                                                                             1.00                                                                              23.30            1DLC 204                    ATOM  81 CB SER 71 43.795                                                                             41.111                                                                             35.171                                                                             1.00                                                                              25.61            1DLC 205                    ATOM  82 OG SER 71 43.497                                                                             39.802                                                                             34.733                                                                             1.00                                                                              34.05            1DLC 206                    ATOM  83 N  VAL 72 43.153                                                                             43.698                                                                             36.787                                                                             1.00                                                                              20.94            1DLC 207                    ATOM  84 CA VAL 72 43.532                                                                             45.037                                                                             37.232                                                                             1.00                                                                              20.83            1DLC 208                    ATOM  85 C  VAL 72 43.556                                                                             45.113                                                                             38.755                                                                             1.00                                                                              21.24            1DLC 209                    ATOM  86 O  VAL 72 44.528                                                                             45.584                                                                             39.346                                                                             1.00                                                                              23.21            1DLC 210                    ATOM  87 CB VAL 72 42.572                                                                             46.104                                                                             36.673                                                                             1.00                                                                              22.69            1DLC 211                    ATOM  88 CG1                                                                               VAL 72 42.850                                                                             47.458                                                                             37.309                                                                             1.00                                                                              24.49            1DLC 212                    ATOM  89 CG2                                                                               VAL 72 42.738                                                                             46.203                                                                             35.165                                                                             1.00                                                                              25.89            1DLC 213                    ATOM  90 N  VAL 73 42.493                                                                             44.613                                                                             39.380                                                                             1.00                                                                              19.28            1DLC 214                    ATOM  91 CA VAL 73 42.377                                                                             44.600                                                                             40.834                                                                             1.00                                                                              15.95            1DLC 215                    ATOM  92 C  VAL 73 43.523                                                                             43.777                                                                             41.408                                                                             1.00                                                                              15.90            1DLC 216                    ATOM  93 O  VAL 73 44.169                                                                             44.181                                                                             42.373                                                                             1.00                                                                              19.54            1DLC 217                    ATOM  94 CB VAL 73 40.993                                                                             44.023                                                                             41.277                                                                             1.00                                                                              15.19            1DLC 218                    ATOM  95 CG1                                                                               VAL 73 40.977                                                                             43.726                                                                             42.762                                                                             1.00                                                                              11.40            1DLC 219                    ATOM  96 CG2                                                                               VAL 73 39.882                                                                             45.005                                                                             40.936                                                                             1.00                                                                              8.14             1DLC 220                    ATOM  97 N  GLY 74 43.804                                                                             42.643                                                                             40.773                                                                             1.00                                                                              18.80            1DLC 221                    ATOM  98 CA GLY 74 44.888                                                                             41.786                                                                             41.225                                                                             1.00                                                                              20.25            1DLC 222                    ATOM  99 C  GLY 74 46.250                                                                             42.465                                                                             41.136                                                                             1.00                                                                              22.94            1DLC 223                    ATOM  100                                                                               O  GLY 74 47.061                                                                             42.353                                                                             42.051                                                                             1.00                                                                              24.08            1DLC 224                    ATOM  101                                                                               N  ASP 75 46.493                                                                             43.183                                                                             40.043                                                                             1.00                                                                              21.18            1DLC 225                    ATOM  102                                                                               CA ASP 75 47.750                                                                             43.892                                                                             39.849                                                                             1.00                                                                              25.01            1DLC 226                    ATOM  103                                                                               C  ASP 75 47.858                                                                             45.070                                                                             40.810                                                                             1.00                                                                              25.78            1DLC 227                    ATOM  104                                                                               O  ASP 75 48.904                                                                             45.296                                                                             41.423                                                                             1.00                                                                              27.64            1DLC 228                    ATOM  105                                                                               CB ASP 75 47.873                                                                             44.394                                                                             38.404                                                                             1.00                                                                              31.86            1DLC 229                    ATOM  106                                                                               CG ASP 75 48.091                                                                             43.263                                                                             37.397                                                                             1.00                                                                              35.66            1DLC 230                    ATOM  107                                                                               OD1                                                                               ASP 75 48.511                                                                             42.153                                                                             37.802                                                                             1.00                                                                              39.68            1DLC 231                    ATOM  108                                                                               OD2                                                                               ASP 75 47.847                                                                             43.487                                                                             36.189                                                                             1.00                                                                              42.21            1DLC 232                    ATOM  109                                                                               N  LEU 76 46.772                                                                             45.819                                                                             40.947                                                                             1.00                                                                              26.59            1DLC 233                    ATOM  110                                                                               CA LEU 76 46.755                                                                             46.967                                                                             41.847                                                                             1.00                                                                              24.97            1DLC 234                    ATOM  111                                                                               C  LEU 76 47.065                                                                             46.549                                                                             43.276                                                                             1.00                                                                              23.34            1DLC 235                    ATOM  112                                                                               O  LEU 76 47.690                                                                             47.303                                                                             44.018                                                                             1.00                                                                              23.84            1DLC 236                    ATOM  113                                                                               CB LEU 76 45.410                                                                             47.678                                                                             41.790                                                                             1.00                                                                              24.54            1DLC 237                    ATOM  114                                                                               CG LEU 76 45.214                                                                             48.589                                                                             40.588                                                                             1.00                                                                              21.89            1DLC 238                    ATOM  115                                                                               CD1                                                                               LEU 76 43.743                                                                             48.951                                                                             40.475                                                                             1.00                                                                              23.58            1DLC 239                    ATOM  116                                                                               CD2                                                                               LEU 76 46.081                                                                             49.830                                                                             40.737                                                                             1.00                                                                              20.30            1DLC 240                    ATOM  117                                                                               N  LEU 77 46.655                                                                             45.339                                                                             43.649                                                                             1.00                                                                              22.54            1DLC 241                    ATOM  118                                                                               CA LEU 77 46.928                                                                             44.834                                                                             44.992                                                                             1.00                                                                              23.75            1DLC 242                    ATOM  119                                                                               C  LEU 77 48.440                                                                             44.786                                                                             45.278                                                                             1.00                                                                              24.55            1DLC 243                    ATOM  120                                                                               O  LEU 77 48.864                                                                             44.713                                                                             46.435                                                                             1.00                                                                              25.25            1DLC 244                    ATOM  121                                                                               CB LEU 77 46.290                                                                             43.453                                                                             45.198                                                                             1.00                                                                              22.14            1DLC 245                    ATOM  122                                                                               CG LEU 77 44.817                                                                             43.440                                                                             45.633                                                                             1.00                                                                              23.83            1DLC 246                    ATOM  123                                                                               CD1                                                                               LEU 77 44.298                                                                             42.016                                                                             45.692                                                                             1.00                                                                              21.52            1DLC 247                    ATOM  124                                                                               CD2                                                                               LEU 77 44.652                                                                             44.116                                                                             46.991                                                                             1.00                                                                              19.85            1DLC 248                    ATOM  125                                                                               N  GLY 78 49.240                                                                             44.837                                                                             44.215                                                                             1.00                                                                              24.11            1DLC 249                    ATOM  126                                                                               CA GLY 78 50.684                                                                             44.823                                                                             44.356                                                                             1.00                                                                              23.63            1DLC 250                    ATOM  127                                                                               C  GLY 78 51.337                                                                             46.203                                                                             44.380                                                                             1.00                                                                              25.07            1DLC 251                    ATOM  128                                                                               O  GLY 78 52.481                                                                             46.329                                                                             44.795                                                                             1.00                                                                              28.69            1DLC 252                    ATOM  129                                                                               N  VAL 79 50.634                                                                             47.238                                                                             43.930                                                                             1.00                                                                              24.83            1DLC 253                    ATOM  130                                                                               CA VAL 79 51.190                                                                             48.599                                                                             43.920                                                                             1.00                                                                              22.91            1DLC 254                    ATOM  131                                                                               C  VAL 79 50.332                                                                             49.576                                                                             44.728                                                                             1.00                                                                              23.48            1DLC 255                    ATOM  132                                                                               O  VAL 79 50.285                                                                             50.775                                                                             44.461                                                                             1.00                                                                              28.13            1DLC 256                    ATOM  133                                                                               CB VAL 79 51.361                                                                             49.136                                                                             42.474                                                                             1.00                                                                              19.52            1DLC 257                    ATOM  134                                                                               CG1                                                                               VAL 79 52.454                                                                             48.379                                                                             41.769                                                                             1.00                                                                              19.64            1DLC 258                    ATOM  135                                                                               CG2                                                                               VAL 79 50.072                                                                             49.007                                                                             41.701                                                                             1.00                                                                              18.98            1DLC 259                    ATOM  136                                                                               N  VAL 80 49.666                                                                             49.047                                                                             45.736                                                                             1.00                                                                              23.04            1DLC 260                    ATOM  137                                                                               CA VAL 80 48.795                                                                             49.835                                                                             46.588                                                                             1.00                                                                              21.33            1DLC 261                    ATOM  138                                                                               C  VAL 80 49.632                                                                             50.446                                                                             47.753                                                                             1.00                                                                              24.09            1DLC 262                    ATOM  139                                                                               O  VAL 80 50.565                                                                             49.810                                                                             48.267                                                                             1.00                                                                              24.41            1DLC 263                    ATOM  140                                                                               CB VAL 80 47.575                                                                             48.936                                                                             46.982                                                                             1.00                                                                              16.03            1DLC 264                    ATOM  141                                                                               CG1                                                                               VAL 80 47.581                                                                             48.546                                                                             48.431                                                                             1.00                                                                              16.04            1DLC 265                    ATOM  142                                                                               CG2                                                                               VAL 80 46.295                                                                             49.576                                                                             46.531                                                                             1.00                                                                              8.70             1DLC 266                    ATOM  143                                                                               N  GLY 81 49.345                                                                             51.694                                                                             48.123                                                                             1.00                                                                              23.56            1DLC 267                    ATOM  144                                                                               CA GLY 81 50.134                                                                             52.364                                                                             49.150                                                                             1.00                                                                              20.79            1DLC 268                    ATOM  145                                                                               C  GLY 81 51.281                                                                             53.059                                                                             48.416                                                                             1.00                                                                              24.82            1DLC 269                    ATOM  146                                                                               O  GLY 81 51.128                                                                             53.400                                                                             47.244                                                                             1.00                                                                              26.66            1DLC 270                    ATOM  147                                                                               N  PHE 82 52.419                                                                             53.292                                                                             49.067                                                                             1.00                                                                              26.10            1DLC 271                    ATOM  148                                                                               CA PHE 82 53.567                                                                             53.934                                                                             48.401                                                                             1.00                                                                              24.09            1DLC 272                    ATOM  149                                                                               C  PHE 82 54.383                                                                             52.816                                                                             47.747                                                                             1.00                                                                              24.46            1DLC 273                    ATOM  150                                                                               O  PHE 82 55.143                                                                             52.114                                                                             48.425                                                                             1.00                                                                              26.54            1DLC 274                    ATOM  151                                                                               CB PHE 82 54.429                                                                             54.684                                                                             49.417                                                                             1.00                                                                              22.55            1DLC 275                    ATOM  152                                                                               CG PHE 82 55.329                                                                             55.721                                                                             48.808                                                                             1.00                                                                              27.94            1DLC 276                    ATOM  153                                                                               CD1                                                                               PHE 82 56.374                                                                             55.359                                                                             47.963                                                                             1.00                                                                              31.41            1DLC 277                    ATOM  154                                                                               CD2                                                                               PHE 82 55.136                                                                             57.069                                                                             49.080                                                                             1.00                                                                              30.52            1DLC 278                    ATOM  155                                                                               CE1                                                                               PHE 82 57.215                                                                             56.327                                                                             47.395                                                                             1.00                                                                              31.44            1DLC 279                    ATOM  156                                                                               CE2                                                                               PHE 82 55.972                                                                             58.048                                                                             48.518                                                                             1.00                                                                              31.81            1DLC 280                    ATOM  157                                                                               CZ PHE 82 57.012                                                                             57.673                                                                             47.674                                                                             1.00                                                                              30.74            1DLC 281                    ATOM  158                                                                               N  PRO 83 54.278                                                                             52.671                                                                             46.412                                                                             1.00                                                                              23.78            1DLC 282                    ATOM  159                                                                               CA PRO 83 54.988                                                                             51.632                                                                             45.663                                                                             1.00                                                                              26.68            1DLC 283                    ATOM  160                                                                               C  PRO 83 56.418                                                                             51.983                                                                             45.255                                                                             1.00                                                                              30.99            1DLC 284                    ATOM  161                                                                               O  PRO 83 56.763                                                                             53.156                                                                             45.095                                                                             1.00                                                                              31.60            1DLC 285                    ATOM  162                                                                               CB PRO 83 54.107                                                                             51.475                                                                             44.430                                                                             1.00                                                                              23.32            1DLC 286                    ATOM  163                                                                               CG PRO 83 53.801                                                                             52.905                                                                             44.103                                                                             1.00                                                                              24.30            1DLC 287                    ATOM  164                                                                               CD PRO 83 53.578                                                                             53.578                                                                             45.481                                                                             1.00                                                                              24.78            1DLC 288                    ATOM  165                                                                               N  PHE 84 57.248                                                                             50.962                                                                             45.054                                                                             1.00                                                                              35.72            1DLC 289                    ATOM  166                                                                               CA PHE 84 58.610                                                                             51.222                                                                             44.622                                                                             1.00                                                                              37.68            1DLC 290                    ATOM  167                                                                               C  PHE 84 58.622                                                                             51.455                                                                             43.101                                                                             1.00                                                                              36.16            1DLC 291                    ATOM  168                                                                               O  PHE 84 57.928                                                                             50.768                                                                             42.344                                                                             1.00                                                                              35.44            1DLC 292                    ATOM  169                                                                               CB PHE 84 59.585                                                                             50.142                                                                             45.149                                                                             1.00                                                                              43.35            1DLC 293                    ATOM  170                                                                               CG PHE 84 60.018                                                                             49.109                                                                             44.139                                                                             1.00                                                                              53.50            1DLC 294                    ATOM  171                                                                               CD1                                                                               PHE 84 60.836                                                                             49.450                                                                             43.055                                                                             1.00                                                                              55.35            1DLC 295                    ATOM  172                                                                               CD2                                                                               PHE 84 59.682                                                                             47.768                                                                             44.324                                                                             1.00                                                                              58.10            1DLC 296                    ATOM  173                                                                               CE1                                                                               PHE 84 61.311                                                                             48.473                                                                             42.178                                                                             1.00                                                                              57.42            1DLC 297                    ATOM  174                                                                               CE2                                                                               PHE 84 60.156                                                                             46.778                                                                             43.448                                                                             1.00                                                                              59.43            1DLC 298                    ATOM  175                                                                               CZ PHE 84 60.971                                                                             47.133                                                                             42.375                                                                             1.00                                                                              58.66            1DLC 299                    ATOM  176                                                                               N  GLY 85 59.320                                                                             52.515                                                                             42.701                                                                             1.00                                                                              34.26            1DLC 300                    ATOM  177                                                                               CA GLY 85 59.427                                                                             52.923                                                                             41.308                                                                             1.00                                                                              31.90            1DLC 301                    ATOM  178                                                                               C  GLY 85 59.414                                                                             51.874                                                                             40.213                                                                             1.00                                                                              31.82            1DLC 302                    ATOM  179                                                                               O  GLY 85 58.751                                                                             52.062                                                                             39.193                                                                             1.00                                                                              33.93            1DLC 303                    ATOM  180                                                                               N  GLY 86 60.183                                                                             50.803                                                                             40.385                                                                             1.00                                                                              30.52            1DLC 304                    ATOM  181                                                                               CA GLY 86 60.205                                                                             49.750                                                                             39.380                                                                             1.00                                                                              30.25            1DLC 305                    ATOM  182                                                                               C  GLY 86 58.868                                                                             49.035                                                                             39.291                                                                             1.00                                                                              29.35            1DLC 306                    ATOM  183                                                                               O  GLY 86 58.369                                                                             48.752                                                                             38.204                                                                             1.00                                                                              29.94            1DLC 307                    ATOM  184                                                                               N  ALA 87 58.273                                                                             48.764                                                                             40.445                                                                             1.00                                                                              27.51            1DLC 308                    ATOM  185                                                                               CA ALA 87 56.980                                                                             48.103                                                                             40.492                                                                             1.00                                                                              26.98            1DLC 309                    ATOM  186                                                                               C  ALA 87 55.905                                                                             48.972                                                                             39.833                                                                             1.00                                                                              27.22            1DLC 310                    ATOM  187                                                                               O  ALA 87 55.085                                                                             48.473                                                                             39.064                                                                             1.00                                                                              31.29            1DLC 311                    ATOM  188                                                                               CB ALA 87 56.606                                                                             47.796                                                                             41.927                                                                             1.00                                                                              28.74            1DLC 312                    ATOM  189                                                                               N  LEU 88 55.944                                                                             50.276                                                                             40.106                                                                             1.00                                                                              26.83            1DLC 313                    ATOM  190                                                                               CA LEU 88 54.982                                                                             51.239                                                                             39.551                                                                             1.00                                                                              25.69            1DLC 314                    ATOM  191                                                                               C  LEU 88 55.005                                                                             51.264                                                                             38.018                                                                             1.00                                                                              27.21            1DLC 315                    ATOM  192                                                                               O  LEU 88 53.955                                                                             51.221                                                                             37.364                                                                             1.00                                                                              27.87            1DLC 316                    ATOM  193                                                                               CB LEU 88 55.274                                                                             52.637                                                                             40.110                                                                             1.00                                                                              27.08            1DLC 317                    ATOM  194                                                                               CG LEU 88 54.208                                                                             53.744                                                                             40.185                                                                             1.00                                                                              27.37            1DLC 318                    ATOM  195                                                                               CD1                                                                               LEU 88 54.504                                                                             54.862                                                                             39.217                                                                             1.00                                                                              24.51            1DLC 319                    ATOM  196                                                                               CD2                                                                               LEU 88 52.817                                                                             53.179                                                                             39.972                                                                             1.00                                                                              30.41            1DLC 320                    ATOM  197                                                                               N  VAL 89 56.207                                                                             51.308                                                                             37.448                                                                             1.00                                                                              28.98            1DLC 321                    ATOM  198                                                                               CA VAL 89 56.369                                                                             51.325                                                                             35.993                                                                             1.00                                                                              28.90            1DLC 322                    ATOM  199                                                                               C  VAL 89 55.898                                                                             50.001                                                                             35.387                                                                             1.00                                                                              29.01            1DLC 323                    ATOM  200                                                                               O  VAL 89 55.165                                                                             49.999                                                                             34.396                                                                             1.00                                                                              28.22            1DLC 324                    ATOM  201                                                                               CB VAL 89 57.828                                                                             51.644                                                                             35.594                                                                             1.00                                                                              27.87            1DLC 325                    ATOM  202                                                                               CG1                                                                               VAL 89 57.975                                                                             51.678                                                                             34.082                                                                             1.00                                                                              24.97            1DLC 326                    ATOM  203                                                                               CG2                                                                               VAL 89 58.222                                                                             52.996                                                                             36.169                                                                             1.00                                                                              28.04            1DLC 327                    ATOM  204                                                                               N  SER 90 56.278                                                                             48.885                                                                             36.013                                                                             1.00                                                                              30.42            1DLC 328                    ATOM  205                                                                               CA SER 90 55.856                                                                             47.551                                                                             35.559                                                                             1.00                                                                              32.29            1DLC 329                    ATOM  206                                                                               C  SER 90 54.342                                                                             47.506                                                                             35.485                                                                             1.00                                                                              32.55            1DLC 330                    ATOM  207                                                                               O  SER 90 53.765                                                                             47.085                                                                             34.479                                                                             1.00                                                                              34.09            1DLC 331                    ATOM  208                                                                               CB SER 90 56.295                                                                             46.472                                                                             36.544                                                                             1.00                                                                              34.34            1DLC 332                    ATOM  209                                                                               OG SER 90 57.694                                                                             46.292                                                                             36.525                                                                             1.00                                                                              46.73            1DLC 333                    ATOM  210                                                                               N  PHE 91 53.701                                                                             47.924                                                                             36.575                                                                             1.00                                                                              31.31            1DLC 334                    ATOM  211                                                                               CA PHE 91 52.249                                                                             47.956                                                                             36.633                                                                             1.00                                                                              29.77            1DLC 335                    ATOM  212                                                                               C  PHE 91 51.712                                                                             48.737                                                                             35.441                                                                             1.00                                                                              29.48            1DLC 336                    ATOM  213                                                                               O  PHE 91 50.912                                                                             48.224                                                                             34.668                                                                             1.00                                                                              31.29            1DLC 337                    ATOM  214                                                                               CB PHE 91 51.758                                                                             48.622                                                                             37.924                                                                             1.00                                                                              29.25            1DLC 338                    ATOM  215                                                                               CG PHE 91 50.285                                                                             48.926                                                                             37.911                                                                             1.00                                                                              27.24            1DLC 339                    ATOM  216                                                                               CD1                                                                               PHE 91 49.354                                                                             47.923                                                                             38.151                                                                             1.00                                                                              24.90            1DLC 340                    ATOM  217                                                                               CD2                                                                               PHE 91 49.828                                                                             50.197                                                                             37.584                                                                             1.00                                                                              24.88            1DLC 341                    ATOM  218                                                                               CE1                                                                               PHE 91 47.996                                                                             48.176                                                                             38.057                                                                             1.00                                                                              24.42            1DLC 342                    ATOM  219                                                                               CE2                                                                               PHE 91 48.469                                                                             50.458                                                                             37.489                                                                             1.00                                                                              23.79            1DLC 343                    ATOM  220                                                                               CZ PHE 91 47.554                                                                             49.446                                                                             37.724                                                                             1.00                                                                              22.85            1DLC 344                    ATOM  221                                                                               N  TYR 92 52.176                                                                             49.972                                                                             35.294                                                                             1.00                                                                              29.52            1DLC 345                    ATOM  222                                                                               CA TYR 92 51.736                                                                             50.835                                                                             34.211                                                                             1.00                                                                              29.00            1DLC 346                    ATOM  223                                                                               C  TYR 92 51.764                                                                             50.214                                                                             32.815                                                                             1.00                                                                              30.26            1DLC 347                    ATOM  224                                                                               O  TYR 92 50.858                                                                             50.466                                                                             32.017                                                                             1.00                                                                              30.35            1DLC 348                    ATOM  225                                                                               CB TYR 92 52.524                                                                             52.141                                                                             34.222                                                                             1.00                                                                              29.47            1DLC 349                    ATOM  226                                                                               CG TYR 92 51.925                                                                             53.227                                                                             35.088                                                                             1.00                                                                              27.60            1DLC 350                    ATOM  227                                                                               CD1                                                                               TYR 92 50.587                                                                             53.603                                                                             34.947                                                                             1.00                                                                              27.51            1DLC 351                    ATOM  228                                                                               CD2                                                                               TYR 92 52.716                                                                             53.938                                                                             35.993                                                                             1.00                                                                              24.64            1DLC 352                    ATOM  229                                                                               CE1                                                                               TYR 92 50.062                                                                             54.669                                                                             35.677                                                                             1.00                                                                              25.83            1DLC 353                    ATOM  230                                                                               CE2                                                                               TYR 92 52.197                                                                             54.999                                                                             36.726                                                                             1.00                                                                              21.65            1DLC 354                    ATOM  231                                                                               CZ TYR 92 50.876                                                                             55.363                                                                             36.562                                                                             1.00                                                                              23.23            1DLC 355                    ATOM  232                                                                               OH TYR 92 50.380                                                                             56.440                                                                             37.260                                                                             1.00                                                                              21.02            1DLC 356                    ATOM  233                                                                               N  THR 93 52.774                                                                             49.396                                                                             32.515                                                                             1.00                                                                              30.64            1DLC 357                    ATOM  234                                                                               CA THR 93 52.839                                                                             48.771                                                                             31.190                                                                             1.00                                                                              32.20            1DLC 358                    ATOM  235                                                                               C  THR 93 51.743                                                                             47.724                                                                             31.004                                                                             1.00                                                                              33.10            1DLC 359                    ATOM  236                                                                               O  THR 93 51.126                                                                             47.658                                                                             29.945                                                                             1.00                                                                              34.96            1DLC 360                    ATOM  237                                                                               CB THR 93 54.226                                                                             48.171                                                                             30.866                                                                             1.00                                                                              33.29            1DLC 361                    ATOM  238                                                                               OG1                                                                               THR 93 54.487                                                                             47.041                                                                             31.704                                                                             1.00                                                                              39.40            1DLC 362                    ATOM  239                                                                               CG2                                                                               THR 93 55.308                                                                             49.213                                                                             31.080                                                                             1.00                                                                              34.17            1DLC 363                    ATOM  240                                                                               N  ASN 94 51.479                                                                             46.926                                                                             32.038                                                                             1.00                                                                              33.43            1DLC 364                    ATOM  241                                                                               CA ASN 94 50.406                                                                             45.929                                                                             31.965                                                                             1.00                                                                              36.98            1DLC 365                    ATOM  242                                                                               C  ASN 94 49.089                                                                             46.685                                                                             31.856                                                                             1.00                                                                              35.78            1DLC 366                    ATOM  243                                                                               O  ASN 94 48.244                                                                             46.375                                                                             31.018                                                                             1.00                                                                              37.99            1DLC 367                    ATOM  244                                                                               CB ASN 94 50.348                                                                             45.068                                                                             33.230                                                                             1.00                                                                              44.19            1DLC 368                    ATOM  245                                                                               CG ASN 94 51.398                                                                             43.978                                                                             33.253                                                                             1.00                                                                              51.52            1DLC 369                    ATOM  246                                                                               OD1                                                                               ASN 94 52.109                                                                             43.753                                                                             32.272                                                                             1.00                                                                              54.17            1DLC 370                    ATOM  247                                                                               ND2                                                                               ASN 94 51.490                                                                             43.277                                                                             34.381                                                                             1.00                                                                              54.88            1DLC 371                    ATOM  248                                                                               N  PHE 95 48.942                                                                             47.692                                                                             32.713                                                                             1.00                                                                              33.93            1DLC 372                    ATOM  249                                                                               CA PHE 95 47.755                                                                             48.538                                                                             32.771                                                                             1.00                                                                              33.38            1DLC 373                    ATOM  250                                                                               C  PHE 95 47.398                                                                             49.047                                                                             31.385                                                                             1.00                                                                              32.29            1DLC 374                    ATOM  251                                                                               O  PHE 95 46.270                                                                             48.895                                                                             30.927                                                                             1.00                                                                              34.55            1DLC 375                    ATOM  252                                                                               CB PHE 95 48.017                                                                             49.715                                                                             33.713                                                                             1.00                                                                              33.16            1DLC 376                    ATOM  253                                                                               CG PHE 95 46.806                                                                             50.551                                                                             34.005                                                                             1.00                                                                              32.63            1DLC 377                    ATOM  254                                                                               CD1                                                                               PHE 95 45.602                                                                             49.953                                                                             34.386                                                                             1.00                                                                              30.05            1DLC 378                    ATOM  255                                                                               CD2                                                                               PHE 95 46.873                                                                             51.941                                                                             33.920                                                                             1.00                                                                              31.23            1DLC 379                    ATOM  256                                                                               CE1                                                                               PHE 95 44.485                                                                             50.726                                                                             34.678                                                                             1.00                                                                              29.10            1DLC 380                    ATOM  257                                                                               CE2                                                                               PHE 95 45.761                                                                             52.726                                                                             34.210                                                                             1.00                                                                              28.92            1DLC 381                    ATOM  258                                                                               CZ PHE 95 44.566                                                                             52.117                                                                             34.590                                                                             1.00                                                                              31.14            1DLC 382                    ATOM  259                                                                               N  LEU 96 48.380                                                                             49.614                                                                             30.702                                                                             1.00                                                                              34.97            1DLC 383                    ATOM  260                                                                               CA LEU 96 48.166                                                                             50.126                                                                             29.360                                                                             1.00                                                                              35.92            1DLC 384                    ATOM  261                                                                               C  LEU 96 47.771                                                                             49.028                                                                             28.384                                                                             1.00                                                                              36.69            1DLC 385                    ATOM  262                                                                               O  LEU 96 46.903                                                                             49.230                                                                             27.539                                                                             1.00                                                                              39.72            1DLC 386                    ATOM  263                                                                               CB LEU 96 49.409                                                                             50.869                                                                             28.862                                                                             1.00                                                                              39.72            1DLC 387                    ATOM  264                                                                               CG LEU 96 49.427                                                                             52.393                                                                             29.075                                                                             1.00                                                                              42.79            1DLC 388                    ATOM  265                                                                               CD1                                                                               LEU 96 49.134                                                                             52.771                                                                             30.537                                                                             1.00                                                                              43.39            1DLC 389                    ATOM  266                                                                               CD2                                                                               LEU 96 50.776                                                                             52.937                                                                             28.633                                                                             1.00                                                                              45.04            1DLC 390                    ATOM  267                                                                               N  ASN 97 48.371                                                                             47.853                                                                             28.523                                                                             1.00                                                                              37.06            1DLC 391                    ATOM  268                                                                               CA ASN 97 48.050                                                                             46.738                                                                             27.630                                                                             1.00                                                                              40.47            1DLC 392                    ATOM  269                                                                               C  ASN 97 46.665                                                                             46.150                                                                             27.893                                                                             1.00                                                                              39.49            1DLC 393                    ATOM  270                                                                               O  ASN 97 45.986                                                                             45.680                                                                             26.981                                                                             1.00                                                                              41.34            1DLC 394                    ATOM  271                                                                               CB ASN 97 49.103                                                                             45.629                                                                             27.741                                                                             1.00                                                                              49.91            1DLC 395                    ATOM  272                                                                               CG ASN 97 50.459                                                                             46.054                                                                             27.219                                                                             1.00                                                                              42.87            1DLC 396                    ATOM  273                                                                               OD1                                                                               ASN 97 51.489                                                                             45.589                                                                             27.699                                                                             1.00                                                                              47.11            1DLC 397                    ATOM  274                                                                               ND2                                                                               ASN 97 50.469                                                                             46.941                                                                             26.234                                                                             1.00                                                                              38.77            1DLC 398                    ATOM  275                                                                               N  THR 98 46.244                                                                             46.214                                                                             29.144                                                                             1.00                                                                              38.36            1DLC 399                    ATOM  276                                                                               CA THR 98 44.959                                                                             45.677                                                                             29.543                                                                             1.00                                                                              36.23            1DLC 400                    ATOM  277                                                                               C  THR 98 43.798                                                                             46.638                                                                             29.306                                                                             1.00                                                                              33.62            1DLC 401                    ATOM  278                                                                               O  THR 98 42.957                                                                             46.412                                                                             28.445                                                                             1.00                                                                              34.42            1DLC 402                    ATOM  279                                                                               CB THR 98 44.983                                                                             45.290                                                                             31.039                                                                             1.00                                                                              37.03            1DLC 403                    ATOM  280                                                                               OG1                                                                               THR 98 46.134                                                                             44.479                                                                             31.302                                                                             1.00                                                                              36.69            1DLC 404                    ATOM  281                                                                               CG2                                                                               THR 98 43.726                                                                             44.516                                                                             31.427                                                                             1.00                                                                              39.60            1DLC 405                    ATOM  282                                                                               N  ILE 99 43.796                                                                             47.740                                                                             30.045                                                                             1.00                                                                              31.37            1DLC 406                    ATOM  283                                                                               CA ILE 99 42.720                                                                             48.722                                                                             29.983                                                                             1.00                                                                              28.14            1DLC 407                    ATOM  284                                                                               C  ILE 99 42.837                                                                             49.822                                                                             28.923                                                                             1.00                                                                              30.20            1DLC 408                    ATOM  285                                                                               O  ILE 99 41.827                                                                             50.244                                                                             28.351                                                                             1.00                                                                              30.60            1DLC 409                    ATOM  286                                                                               CB ILE 99 42.523                                                                             49.378                                                                             31.383                                                                             1.00                                                                              25.44            1DLC 410                    ATOM  287                                                                               CG1                                                                               ILE 99 42.274                                                                             48.301                                                                             32.445                                                                             1.00                                                                              23.31            1DLC 411                    ATOM  288                                                                               CG2                                                                               ILE 99 41.389                                                                             50.388                                                                             31.362                                                                             1.00                                                                              24.47            1DLC 412                    ATOM  289                                                                               CD1                                                                               ILE 99 41.002                                                                             47.504                                                                             32.253                                                                             1.00                                                                              24.55            1DLC 413                    ATOM  290                                                                               N  TRP 100                                                                               44.056                                                                             50.270                                                                             28.631                                                                             1.00                                                                              29.78            1DLC 414                    ATOM  291                                                                               CA TRP 100                                                                               44.226                                                                             51.355                                                                             27.661                                                                             1.00                                                                              30.90            1DLC 415                    ATOM  292                                                                               C  TRP 100                                                                               44.913                                                                             51.060                                                                             26.312                                                                             1.00                                                                              34.13            1DLC 416                    ATOM  293                                                                               O  TRP 100                                                                               45.593                                                                             51.932                                                                             25.755                                                                             1.00                                                                              37.64            1DLC 417                    ATOM  294                                                                               CB TRP 100                                                                               44.916                                                                             52.548                                                                             28.341                                                                             1.00                                                                              25.25            1DLC 418                    ATOM  295                                                                               CG TRP 100                                                                               44.160                                                                             53.138                                                                             29.509                                                                             1.00                                                                              21.47            1DLC 419                    ATOM  296                                                                               CD1                                                                               TRP 100                                                                               44.326                                                                             52.835                                                                             30.836                                                                             1.00                                                                              19.22            1DLC 420                    ATOM  297                                                                               CD2                                                                               TRP 100                                                                               43.173                                                                             54.181                                                                             29.459                                                                             1.00                                                                              19.56            1DLC 421                    ATOM  298                                                                               NE1                                                                               TRP 100                                                                               43.517                                                                             53.635                                                                             31.611                                                                             1.00                                                                              19.74            1DLC 422                    ATOM  299                                                                               CE2                                                                               TRP 100                                                                               42.799                                                                             54.469                                                                             30.795                                                                             1.00                                                                              19.03            1DLC 423                    ATOM  300                                                                               CE3                                                                               TRP 100                                                                               42.576                                                                             54.905                                                                             28.418                                                                             1.00                                                                              16.14            1DLC 424                    ATOM  301                                                                               CZ2                                                                               TRP 100                                                                               41.856                                                                             55.455                                                                             31.116                                                                             1.00                                                                              20.11            1DLC 425                    ATOM  302                                                                               CZ3                                                                               TRP 100                                                                               41.635                                                                             55.887                                                                             28.739                                                                             1.00                                                                              18.05            1DLC 426                    ATOM  303                                                                               CH2                                                                               TRP 100                                                                               41.287                                                                             56.150                                                                             30.079                                                                             1.00                                                                              18.97            1DLC 427                    ATOM  304                                                                               N  PRO 101                                                                               44.702                                                                             49.859                                                                             25.738                                                                             1.00                                                                              35.80            1DLC 428                    ATOM  305                                                                               CA PRO 101                                                                               45.347                                                                             49.557                                                                             24.455                                                                             1.00                                                                              37.30            1DLC 429                    ATOM  306                                                                               C  PRO 101                                                                               44.651                                                                             50.132                                                                             23.217                                                                             1.00                                                                              38.37            1DLC 430                    ATOM  307                                                                               O  PRO 101                                                                               45.309                                                                             50.557                                                                             22.271                                                                             1.00                                                                              39.64            1DLC 431                    ATOM  308                                                                               CB PRO 101                                                                               45.322                                                                             48.034                                                                             24.431                                                                             1.00                                                                              38.85            1DLC 432                    ATOM  309                                                                               CG PRO 101                                                                               44.017                                                                             47.726                                                                             25.088                                                                             1.00                                                                              35.28            1DLC 433                    ATOM  310                                                                               CD PRO 101                                                                               44.032                                                                             48.658                                                                             26.274                                                                             1.00                                                                              36.12            1DLC 434                    ATOM  311                                                                               N  SER 102                                                                               43.322                                                                             50.129                                                                             23.227                                                                             1.00                                                                              40.19            1DLC 435                    ATOM  312                                                                               CA SER 102                                                                               42.514                                                                             50.620                                                                             22.105                                                                             1.00                                                                              41.68            1DLC 436                    ATOM  313                                                                               C  SER 102                                                                               41.097                                                                             50.916                                                                             22.592                                                                             1.00                                                                              41.86            1DLC 437                    ATOM  314                                                                               O  SER 102                                                                               40.831                                                                             50.852                                                                             23.789                                                                             1.00                                                                              41.66            1DLC 438                    ATOM  315                                                                               CB SER 102                                                                               42.439                                                                             49.547                                                                             21.019                                                                             1.00                                                                              43.16            1DLC 439                    ATOM  316                                                                               OG SER 102                                                                               41.925                                                                             48.330                                                                             21.556                                                                             1.00                                                                              45.57            1DLC 440                    ATOM  317                                                                               N  GLU 103                                                                               40.178                                                                             51.206                                                                             21.674                                                                             1.00                                                                              41.50            1DLC 441                    ATOM  318                                                                               CA GLU 103                                                                               38.800                                                                             51.482                                                                             22.080                                                                             1.00                                                                              43.73            1DLC 442                    ATOM  319                                                                               C  GLU 103                                                                               37.989                                                                             50.207                                                                             22.334                                                                             1.00                                                                              41.43            1DLC 443                    ATOM  320                                                                               O  GLU 103                                                                               36.916                                                                             50.251                                                                             22.937                                                                             1.00                                                                              40.77            1DLC 444                    ATOM  321                                                                               CB GLU 103                                                                               38.078                                                                             52.403                                                                             21.076                                                                             1.00                                                                              48.24            1DLC 445                    ATOM  322                                                                               CG GLU 103                                                                               37.564                                                                             51.764                                                                             19.782                                                                             1.00                                                                              56.59            1DLC 446                    ATOM  323                                                                               CD GLU 103                                                                               38.656                                                                             51.448                                                                             18.766                                                                             1.00                                                                              63.51            1DLC 447                    ATOM  324                                                                               OE1                                                                               GLU 103                                                                               39.739                                                                             52.096                                                                             18.786                                                                             1.00                                                                              66.38            1DLC 448                    ATOM  325                                                                               OE2                                                                               GLU 103                                                                               38.417                                                                             50.544                                                                             17.931                                                                             1.00                                                                              65.54            1DLC 449                    ATOM  326                                                                               N  ASP 104                                                                               38.544                                                                             49.065                                                                             21.947                                                                             1.00                                                                              40.07            1DLC 450                    ATOM  327                                                                               CA ASP 104                                                                               37.856                                                                             47.791                                                                             22.132                                                                             1.00                                                                              41.15            1DLC 451                    ATOM  328                                                                               C  ASP 104                                                                               37.437                                                                             47.481                                                                             23.572                                                                             1.00                                                                              38.99            1DLC 452                    ATOM  329                                                                               O  ASP 104                                                                               36.282                                                                             47.118                                                                             23.816                                                                             1.00                                                                              39.97            1DLC 453                    ATOM  330                                                                               CB ASP 104                                                                               38.674                                                                             46.634                                                                             21.543                                                                             1.00                                                                              44.04            1DLC 454                    ATOM  331                                                                               CG ASP 104                                                                               38.713                                                                             46.656                                                                             20.016                                                                             1.00                                                                              50.06            1DLC 455                    ATOM  332                                                                               OD1                                                                               ASP 104                                                                               37.649                                                                             46.852                                                                             19.375                                                                             1.00                                                                              53.14            1DLC 456                    ATOM  333                                                                               OD2                                                                               ASP 104                                                                               39.811                                                                             46.468                                                                             19.454                                                                             1.00                                                                              53.68            1DLC 457                    ATOM  334                                                                               N  PRO 105                                                                               38.351                                                                             47.651                                                                             24.551                                                                             1.00                                                                              36.35            1DLC 458                    ATOM  335                                                                               CA PRO 105                                                                               37.984                                                                             47.364                                                                             25.944                                                                             1.00                                                                              34.16            1DLC 459                    ATOM  336                                                                               C  PRO 105                                                                               36.845                                                                             48.263                                                                             26.449                                                                             1.00                                                                              33.17            1DLC 460                    ATOM  337                                                                               O  PRO 105                                                                               35.899                                                                             47.794                                                                             27.089                                                                             1.00                                                                              31.65            1DLC 461                    ATOM  338                                                                               CB PRO 105                                                                               39.286                                                                             47.640                                                                             26.703                                                                             1.00                                                                              32.33            1DLC 462                    ATOM  339                                                                               CG PRO 105                                                                               40.336                                                                             47.374                                                                             25.695                                                                             1.00                                                                              32.70            1DLC 463                    ATOM  340                                                                               CD PRO 105                                                                               39.773                                                                             48.023                                                                             24.464                                                                             1.00                                                                              33.69            1DLC 464                    ATOM  341                                                                               N  TRP 106                                                                               36.933                                                                             49.548                                                                             26.127                                                                             1.00                                                                              30.91            1DLC 465                    ATOM  342                                                                               CA TRP 106                                                                               35.928                                                                             50.519                                                                             26.543                                                                             1.00                                                                              31.51            1DLC 466                    ATOM  343                                                                               C  TRP 106                                                                               34.573                                                                             50.226                                                                             25.925                                                                             1.00                                                                              30.83            1DLC 467                    ATOM  344                                                                               O  TRP 106                                                                               33.539                                                                             50.353                                                                             26.572                                                                             1.00                                                                              31.34            1DLC 468                    ATOM  345                                                                               CB TRP 106                                                                               36.404                                                                             51.928                                                                             26.200                                                                             1.00                                                                              30.77            1DLC 469                    ATOM  346                                                                               CG TRP 106                                                                               37.688                                                                             52.230                                                                             26.890                                                                             1.00                                                                              31.17            1DLC 470                    ATOM  347                                                                               CD1                                                                               TRP 106                                                                               38.940                                                                             52.165                                                                             26.356                                                                             1.00                                                                              28.87            1DLC 471                    ATOM  348                                                                               CD2                                                                               TRP 106                                                                               37.858                                                                             52.537                                                                             28.277                                                                             1.00                                                                              31.01            1DLC 472                    ATOM  349                                                                               NE1                                                                               TRP 106                                                                               39.879                                                                             52.396                                                                             27.327                                                                             1.00                                                                              27.96            1DLC 473                    ATOM  350                                                                               CE2                                                                               TRP 106                                                                               39.245                                                                             52.629                                                                             28.517                                                                             1.00                                                                              29.45            1DLC 474                    ATOM  351                                                                               CE3                                                                               TRP 106                                                                               36.971                                                                             52.737                                                                             29.346                                                                             1.00                                                                              32.12            1DLC 475                    ATOM  352                                                                               CZ2                                                                               TRP 106                                                                               39.771                                                                             52.912                                                                             29.781                                                                             1.00                                                                              31.59            1DLC 476                    ATOM  353                                                                               CZ3                                                                               TRP 106                                                                               37.495                                                                             53.019                                                                             30.607                                                                             1.00                                                                              33.16            1DLC 477                    ATOM  354                                                                               CH2                                                                               TRP 106                                                                               38.884                                                                             53.103                                                                             30.811                                                                             1.00                                                                              31.59            1DLC 478                    ATOM  355                                                                               N  LYS 107                                                                               34.588                                                                             49.786                                                                             24.678                                                                             1.00                                                                              33.17            1DLC 479                    ATOM  356                                                                               CA LYS 107                                                                               33.356                                                                             49.445                                                                             23.979                                                                             1.00                                                                              35.51            1DLC 480                    ATOM  357                                                                               C  LYS 107                                                                               32.718                                                                             48.208                                                                             24.638                                                                             1.00                                                                              31.75            1DLC 481                    ATOM  358                                                                               O  LYS 107                                                                               31.499                                                                             48.136                                                                             24.818                                                                             1.00                                                                              27.83            1DLC 482                    ATOM  359                                                                               CB LYS 107                                                                               33.674                                                                             49.188                                                                             22.506                                                                             1.00                                                                              40.04            1DLC 483                    ATOM  360                                                                               CG LYS 107                                                                               32.519                                                                             49.475                                                                             21.568                                                                             1.00                                                                              49.75            1DLC 484                    ATOM  361                                                                               CD LYS 107                                                                               33.032                                                                             49.919                                                                             20.204                                                                             1.00                                                                              56.89            1DLC 485                    ATOM  362                                                                               CE LYS 107                                                                               34.066                                                                             48.945                                                                             19.643                                                                             1.00                                                                              62.13            1DLC 486                    ATOM  363                                                                               NZ LYS 107                                                                               34.425                                                                             49.301                                                                             18.238                                                                             1.00                                                                              68.80            1DLC 487                    ATOM  364                                                                               N  ALA 108                                                                               33.574                                                                             47.276                                                                             25.055                                                                             1.00                                                                              29.83            1DLC 488                    ATOM  365                                                                               CA ALA 108                                                                               33.160                                                                             46.045                                                                             25.720                                                                             1.00                                                                              28.62            1DLC 489                    ATOM  366                                                                               C  ALA 108                                                                               32.569                                                                             46.312                                                                             27.115                                                                             1.00                                                                              29.18            1DLC 490                    ATOM  367                                                                               O  ALA 108                                                                               31.662                                                                             45.598                                                                             27.559                                                                             1.00                                                                              28.23            1DLC 491                    ATOM  368                                                                               C  ALA 108                                                                               34.344                                                                             45.083                                                                             25.810                                                                             1.00                                                                              27.06            1DLC 492                    ATOM  369                                                                               N  PHE 109                                                                               33.092                                                                             47.327                                                                             27.806                                                                             1.00                                                                              27.51            1DLC 493                    ATOM  370                                                                               CA PHE 109                                                                               32.589                                                                             47.701                                                                             29.129                                                                             1.00                                                                              26.94            1DLC 494                    ATOM  371                                                                               C  PHE 109                                                                               31.193                                                                             48.301                                                                             29.013                                                                             1.00                                                                              27.69            1DLC 495                    ATOM  372                                                                               O  PHE 109                                                                               30.338                                                                             48.104                                                                             29.876                                                                             1.00                                                                              29.41            1DLC 496                    ATOM  373                                                                               CB PHE 109                                                                               33.525                                                                             48.703                                                                             29.805                                                                             1.00                                                                              27.56            1DLC 497                    ATOM  374                                                                               CG PHE 109                                                                               34.672                                                                             48.064                                                                             30.528                                                                             1.00                                                                              32.09            1DLC 498                    ATOM  375                                                                               CD1                                                                               PHE 109                                                                               34.465                                                                             46.954                                                                             31.344                                                                             1.00                                                                              33.41            1DLC 499                    ATOM  376                                                                               CD2                                                                               PHE 109                                                                               35.962                                                                             48.566                                                                             30.396                                                                             1.00                                                                              32.21            1DLC 500                    ATOM  377                                                                               CE1                                                                               PHE 109                                                                               35.523                                                                             46.351                                                                             32.018                                                                             1.00                                                                              34.60            1DLC 501                    ATOM  378                                                                               CE2                                                                               PHE 109                                                                               37.025                                                                             47.972                                                                             31.065                                                                             1.00                                                                              34.23            1DLC 502                    ATOM  379                                                                               CZ PHE 109                                                                               36.805                                                                             46.860                                                                             31.879                                                                             1.00                                                                              34.84            1DLC 503                    ATOM  380                                                                               N  MET 110                                                                               30.970                                                                             49.047                                                                             27.942                                                                             1.00                                                                              26.88            1DLC 504                    ATOM  381                                                                               CA MET 110                                                                               29.671                                                                             49.653                                                                             27.713                                                                             1.00                                                                              29.57            1DLC 505                    ATOM  382                                                                               C  MET 110                                                                               28.666                                                                             48.544                                                                             27.402                                                                             1.00                                                                              31.10            1DLC 506                    ATOM  383                                                                               O  MET 110                                                                               27.614                                                                             48.442                                                                             28.038                                                                             1.00                                                                              30.88            1DLC 507                    ATOM  384                                                                               CB MET 110                                                                               29.751                                                                             50.664                                                                             26.564                                                                             1.00                                                                              29.18            1DLC 508                    ATOM  385                                                                               CG MET 110                                                                               30.604                                                                             51.894                                                                             26.869                                                                             1.00                                                                              28.37            1DLC 509                    ATOM  386                                                                               CD MET 110                                                                               30.715                                                                             53.039                                                                             25.473                                                                             1.00                                                                              32.63            1DLC 510                    ATOM  387                                                                               CE MET 110                                                                               31.965                                                                             54.148                                                                             26.035                                                                             1.00                                                                              35.77            1DLC 511                    ATOM  388                                                                               N  GLU 111                                                                               29.033                                                                             47.672                                                                             26.467                                                                             1.00                                                                              33.04            1DLC 512                    ATOM  389                                                                               CA GLU 111                                                                               28.179                                                                             46.553                                                                             26.078                                                                             1.00                                                                              33.48            1DLC 513                    ATOM  390                                                                               C  GLU 111                                                                               27.885                                                                             45.632                                                                             27.257                                                                             1.00                                                                              31.71            1DLC 514                    ATOM  391                                                                               O  GLU 111                                                                               26.801                                                                             45.054                                                                             27.338                                                                             1.00                                                                              30.92            1DLC 515                    ATOM  392                                                                               CB GLU 111                                                                               28.818                                                                             45.755                                                                             24.937                                                                             1.00                                                                              37.35            1DLC 516                    ATOM  393                                                                               CG GLU 111                                                                               28.863                                                                             46.510                                                                             23.607                                                                             1.00                                                                              45.28            1DLC 517                    ATOM  394                                                                               CD GLU 111                                                                               29.578                                                                             45.753                                                                             22.491                                                                             1.00                                                                              48.00            1DLC 518                    ATOM  395                                                                               OE1                                                                               GLU 111                                                                               29.969                                                                             44.577                                                                             22.690                                                                             1.00                                                                              52.24            1DLC 519                    ATOM  396                                                                               OE2                                                                               GLU 111                                                                               29.755                                                                             46.350                                                                             21.407                                                                             1.00                                                                              49.92            1DLC 520                    ATOM  397                                                                               N  GLN 112                                                                               28.839                                                                             45.526                                                                             28.183                                                                             1.00                                                                              30.24            1DLC 521                    ATOM  398                                                                               CA GLN 112                                                                               28.671                                                                             44.682                                                                             29.368                                                                             1.00                                                                              28.58            1DLC 522                    ATOM  399                                                                               C  GLN 112                                                                               27.431                                                                             45.058                                                                             30.182                                                                             1.00                                                                              28.06            1DLC 523                    ATOM  400                                                                               O  GLN 112                                                                               26.565                                                                             44.217                                                                             30.454                                                                             1.00                                                                              29.19            1DLC 524                    ATOM  401                                                                               CB GLN 112                                                                               29.896                                                                             44.760                                                                             30.280                                                                             1.00                                                                              26.24            1DLC 525                    ATOM  402                                                                               CG GLN 112                                                                               29.763                                                                             43.882                                                                             31.517                                                                             1.00                                                                              27.12            1DLC 526                    ATOM  403                                                                               CD GLN 112                                                                               30.677                                                                             44.295                                                                             32.644                                                                             1.00                                                                              27.16            1DLC 527                    ATOM  404                                                                               OE1                                                                               GLN 112                                                                               31.050                                                                             45.456                                                                             32.767                                                                             1.00                                                                              27.74            1DLC 528                    ATOM  405                                                                               NE2                                                                               GLN 112                                                                               31.032                                                                             43.348                                                                             33.484                                                                             1.00                                                                              29.40            1DLC 529                    ATOM  406                                                                               N  VAL 113                                                                               27.337                                                                             46.325                                                                             30.560                                                                             1.00                                                                              24.97            1DLC 530                    ATOM  407                                                                               CA VAL 113                                                                               26.201                                                                             46.764                                                                             31.349                                                                             1.00                                                                              23.68            1DLC 531                    ATOM  408                                                                               C  VAL 113                                                                               24.932                                                                             46.792                                                                             30.519                                                                             1.00                                                                              24.60            1DLC 532                    ATOM  409                                                                               O  VAL 113                                                                               23.853                                                                             46.539                                                                             31.031                                                                             1.00                                                                              27.38            1DLC 533                    ATOM  410                                                                               CB VAL 113                                                                               26.462                                                                             48.114                                                                             32.003                                                                             1.00                                                                              20.75            1DLC 534                    ATOM  411                                                                               CG1                                                                               VAL 113                                                                               25.401                                                                             48.398                                                                             33.048                                                                             1.00                                                                              16.74            1DLC 535                    ATOM  412                                                                               CG2                                                                               VAL 113                                                                               27.846                                                                             48.106                                                                             32.642                                                                             1.00                                                                              21.83            1DLC 536                    ATOM  413                                                                               N  GLU 114                                                                               25.060                                                                             47.071                                                                             29.228                                                                             1.00                                                                              28.20            1DLC 537                    ATOM  414                                                                               CA GLU 114                                                                               23.894                                                                             47.081                                                                             28.351                                                                             1.00                                                                              27.34            1DLC 538                    ATOM  415                                                                               C  GLU 114                                                                               23.268                                                                             45.681                                                                             28.368                                                                             1.00                                                                              27.33            1DLC 539                    ATOM  416                                                                               O  GLU 114                                                                               22.048                                                                             45.527                                                                             28.410                                                                             1.00                                                                              27.26            1DLC 540                    ATOM  417                                                                               CB GLU 114                                                                               24.305                                                                             47.455                                                                             26.929                                                                             1.00                                                                              27.02            1DLC 541                    ATOM  418                                                                               CG GLU 114                                                                               24.757                                                                             48.893                                                                             26.776                                                                             1.00                                                                              29.51            1DLC 542                    ATOM  419                                                                               CD GLU 114                                                                               25.075                                                                             49.250                                                                             25.338                                                                             1.00                                                                              29.59            1DLC 543                    ATOM  420                                                                               OE1                                                                               GLU 114                                                                               25.765                                                                             48.464                                                                             24.654                                                                             1.00                                                                              33.56            1DLC 544                    ATOM  421                                                                               OE2                                                                               GLU 114                                                                               24.629                                                                             50.319                                                                             24.883                                                                             1.00                                                                              30.80            1DLC 545                    ATOM  422                                                                               N  ALA 115                                                                               24.128                                                                             44.667                                                                             28.384                                                                             1.00                                                                              25.38            1DLC 546                    ATOM  423                                                                               CA ALA 115                                                                               23.700                                                                             43.276                                                                             28.425                                                                             1.00                                                                              23.38            1DLC 547                    ATOM  424                                                                               C  ALA 115                                                                               22.994                                                                             42.964                                                                             29.735                                                                             1.00                                                                              24.92            1DLC 548                    ATOM  425                                                                               O  ALA 115                                                                               21.939                                                                             42.357                                                                             29.731                                                                             1.00                                                                              30.01            1DLC 549                    ATOM  426                                                                               CB ALA 115                                                                               24.892                                                                             42.357                                                                             28.248                                                                             1.00                                                                              23.08            1DLC 550                    ATOM  427                                                                               N  LEU 116                                                                               23.584                                                                             43.381                                                                             30.850                                                                             1.00                                                                              25.64            1DLC 551                    ATOM  428                                                                               CA LEU 116                                                                               23.008                                                                             43.153                                                                             32.179                                                                             1.00                                                                              26.66            1DLC 552                    ATOM  429                                                                               C  LEU 116                                                                               21.688                                                                             43.895                                                                             32.397                                                                             1.00                                                                              27.99            1DLC 553                    ATOM  430                                                                               O  LEU 116                                                                               20.761                                                                             43.382                                                                             33.023                                                                             1.00                                                                              29.24            1DLC 554                    ATOM  431                                                                               CB LEU 116                                                                               23.992                                                                             43.598                                                                             33.270                                                                             1.00                                                                              25.03            1DLC 555                    ATOM  432                                                                               CG LEU 116                                                                               25.261                                                                             42.770                                                                             33.501                                                                             1.00                                                                              28.01            1DLC 556                    ATOM  433                                                                               CD1                                                                               LEU 116                                                                               26.257                                                                             43.525                                                                             34.380                                                                             1.00                                                                              26.20            1DLC 557                    ATOM  434                                                                               CD2                                                                               LEU 116                                                                               24.890                                                                             41.442                                                                             34.132                                                                             1.00                                                                              27.91            1DLC 558                    ATOM  435                                                                               N  MET 117                                                                               21.614                                                                             45.109                                                                             31.873                                                                             1.00                                                                              28.41            1DLC 559                    ATOM  436                                                                               CA MET 117                                                                               20.442                                                                             45.957                                                                             32.032                                                                             1.00                                                                              30.17            1DLC 560                    ATOM  437                                                                               C  MET 117                                                                               19.390                                                                             45.825                                                                             30.934                                                                             1.00                                                                              31.82            1DLC 561                    ATOM  438                                                                               O  MET 117                                                                               18.252                                                                             46.256                                                                             31.102                                                                             1.00                                                                              31.84            1DLC 562                    ATOM  439                                                                               CB MET 117                                                                               20.903                                                                             47.408                                                                             32.099                                                                             1.00                                                                              30.05            1DLC 563                    ATOM  440                                                                               CG MET 117                                                                               20.528                                                                             48.129                                                                             33.361                                                                             1.00                                                                              31.75            1DLC 564                    ATOM  441                                                                               SD MET 117                                                                               20.999                                                                             47.259                                                                             34.847                                                                             1.00                                                                              32.52            1DLC 565                    ATOM  442                                                                               CE MET 117                                                                               19.682                                                                             47.817                                                                             35.885                                                                             1.00                                                                              24.44            1DLC 566                    ATOM  443                                                                               N  ASP 118                                                                               19.776                                                                             45.223                                                                             29.818                                                                             1.00                                                                              33.29            1DLC 567                    ATOM  444                                                                               CA ASP 118                                                                               18.894                                                                             45.073                                                                             28.666                                                                             1.00                                                                              37.23            1DLC 568                    ATOM  445                                                                               C  ASP 118                                                                               18.412                                                                             46.445                                                                             28.203                                                                             1.00                                                                              37.19            1DLC 569                    ATOM  446                                                                               O  ASP 118                                                                               17.225                                                                             46.683                                                                             27.979                                                                             1.00                                                                              37.25            1DLC 570                    ATOM  447                                                                               CB ASP 118                                                                               17.716                                                                             44.144                                                                             28.956                                                                             1.00                                                                              42.38            1DLC 571                    ATOM  448                                                                               CG ASP 118                                                                               17.205                                                                             43.450                                                                             27.697                                                                             1.00                                                                              47.50            1DLC 572                    ATOM  449                                                                               OD1                                                                               ASP 118                                                                               18.027                                                                             42.797                                                                             27.009                                                                             1.00                                                                              50.29            1DLC 573                    ATOM  450                                                                               OD2                                                                               ASP 118                                                                               15.993                                                                             43.564                                                                             27.392                                                                             1.00                                                                              50.50            1DLC 574                    ATOM  451                                                                               N  GLN 119                                                                               19.372                                                                             47.355                                                                             28.106                                                                             1.00                                                                              39.11            1DLC 575                    ATOM  452                                                                               CA GLN 119                                                                               19.151                                                                             48.722                                                                             27.660                                                                             1.00                                                                              39.37            1DLC 576                    ATOM  453                                                                               C  GLN 119                                                                               20.371                                                                             49.116                                                                             26.849                                                                             1.00                                                                              39.51            1DLC 577                    ATOM  454                                                                               O  GLN 119                                                                               21.416                                                                             48.478                                                                             26.946                                                                             1.00                                                                              41.09            1DLC 578                    ATOM  455                                                                               CB GLN 119                                                                               19.029                                                                             49.674                                                                             28.841                                                                             1.00                                                                              41.10            1DLC 579                    ATOM  456                                                                               CG GLN 119                                                                               17.784                                                                             49.520                                                                             29.657                                                                             1.00                                                                              47.05            1DLC 580                    ATOM  457                                                                               CD GLN 119                                                                               17.628                                                                             50.660                                                                             30.637                                                                             1.00                                                                              52.24            1DLC 581                    ATOM  458                                                                               OE1                                                                               GLN 119                                                                               17.745                                                                             50.484                                                                             31.851                                                                             1.00                                                                              54.31            1DLC 582                    ATOM  459                                                                               NE2                                                                               GLN 119                                                                               17.385                                                                             51.850                                                                             30.111                                                                             1.00                                                                              55.17            1DLC 583                    ATOM  460                                                                               N  LYS 120                                                                               20.250                                                                             50.179                                                                             26.066                                                                             1.00                                                                              41.11            1DLC 584                    ATOM  461                                                                               CA LYS 120                                                                               21.361                                                                             50.647                                                                             25.250                                                                             1.00                                                                              38.74            1DLC 585                    ATOM  462                                                                               C  LYS 120                                                                               21.613                                                                             52.129                                                                             25.433                                                                             1.00                                                                              38.08            1DLC 586                    ATOM  463                                                                               O  LYS 120                                                                               20.710                                                                             52.890                                                                             25.773                                                                             1.00                                                                              39.76            1DLC 587                    ATOM  464                                                                               CB LYS 120                                                                               21.100                                                                             50.341                                                                             23.779                                                                             1.00                                                                              41.32            1DLC 588                    ATOM  465                                                                               CG LYS 120                                                                               21.203                                                                             48.862                                                                             23.444                                                                             1.00                                                                              47.56            1DLC 589                    ATOM  466                                                                               CD LYS 120                                                                               20.881                                                                             48.608                                                                             21.991                                                                             1.00                                                                              54.97            1DLC 590                    ATOM  467                                                                               CE LYS 120                                                                               21.147                                                                             47.160                                                                             21.615                                                                             1.00                                                                              59.79            1DLC 591                    ATOM  468                                                                               NZ LYS 120                                                                               20.761                                                                             46.901                                                                             20.190                                                                             1.00                                                                              67.72            1DLC 592                    ATOM  469                                                                               N  ILE 121                                                                               22.863                                                                             52.524                                                                             25.265                                                                             1.00                                                                              37.13            1DLC 593                    ATOM  470                                                                               CA ILE 121                                                                               23.241                                                                             53.921                                                                             25.385                                                                             1.00                                                                              37.29            1DLC 594                    ATOM  471                                                                               C  ILE 121                                                                               22.939                                                                             54.602                                                                             24.039                                                                             1.00                                                                              38.92            1DLC 595                    ATOM  472                                                                               O  ILE 121                                                                               23.157                                                                             54.009                                                                             22.977                                                                             1.00                                                                              39.34            1DLC 596                    ATOM  473                                                                               CB ILE 121                                                                               24.749                                                                             54.063                                                                             25.715                                                                             1.00                                                                              34.38            1DLC 597                    ATOM  474                                                                               CG1                                                                               ILE 121                                                                               25.097                                                                             53.244                                                                             26.961                                                                             1.00                                                                              35.00            1DLC 598                    ATOM  475                                                                               CG2                                                                               ILE 121                                                                               25.089                                                                             55.514                                                                             25.969                                                                             1.00                                                                              34.52            1DLC 599                    ATOM  476                                                                               CD1                                                                               ILE 121                                                                               26.580                                                                             53.116                                                                             27.247                                                                             1.00                                                                              31.52            1DLC 600                    ATOM  477                                                                               N  ALA 122                                                                               22.383                                                                             55.811                                                                             24.081                                                                             1.00                                                                              37.83            1DLC 601                    ATOM  478                                                                               CA ALA 122                                                                               22.083                                                                             56.545                                                                             22.854                                                                             1.00                                                                              37.13            1DLC 602                    ATOM  479                                                                               C  ALA 122                                                                               23.388                                                                             56.682                                                                             22.075                                                                             1.00                                                                              38.77            1DLC 603                    ATOM  480                                                                               O  ALA 122                                                                               24.391                                                                             57.131                                                                             22.629                                                                             1.00                                                                              42.15            1DLC 604                    ATOM  481                                                                               CB ALA 122                                                                               21.528                                                                             57.909                                                                             23.189                                                                             1.00                                                                              31.82            1DLC 605                    ATOM  482                                                                               N  ASP 123                                                                               23.386                                                                             56.275                                                                             20.808                                                                             1.00                                                                              40.84            1DLC 606                    ATOM  483                                                                               CA ASP 123                                                                               24.588                                                                             56.342                                                                             19.971                                                                             1.00                                                                              42.51            1DLC 607                    ATOM  484                                                                               C  ASP 123                                                                               25.452                                                                             57.587                                                                             20.115                                                                             1.00                                                                              40.46            1DLC 608                    ATOM  485                                                                               O  ASP 123                                                                               26.671                                                                             57.482                                                                             20.157                                                                             1.00                                                                              37.07            1DLC 609                    ATOM  486                                                                               CB ASP 123                                                                               24.239                                                                             56.135                                                                             18.501                                                                             1.00                                                                              51.37            1DLC 610                    ATOM  487                                                                               CG ASP 123                                                                               24.397                                                                             54.690                                                                             18.069                                                                             1.00                                                                              59.26            1DLC 611                    ATOM  488                                                                               OD1                                                                               ASP 123                                                                               25.508                                                                             54.135                                                                             18.240                                                                             1.00                                                                              63.83            1DLC 612                    ATOM  489                                                                               OD2                                                                               ASP 123                                                                               23.414                                                                             54.107                                                                             17.560                                                                             1.00                                                                              65.85            1DLC 613                    ATOM  490                                                                               N  TYR 124                                                                               24.821                                                                             58.756                                                                             20.210                                                                             1.00                                                                              41.62            1DLC 614                    ATOM  491                                                                               CA TYR 124                                                                               25.554                                                                             60.015                                                                             20.361                                                                             1.00                                                                              41.32            1DLC 615                    ATOM  492                                                                               C  TYR 124                                                                               26.390                                                                             59.997                                                                             21.645                                                                             1.00                                                                              41.19            1DLC 616                    ATOM  493                                                                               O  TYR 124                                                                               27.575                                                                             60.341                                                                             21.633                                                                             1.00                                                                              44.09            1DLC 617                    ATOM  494                                                                               CB TYR 124                                                                               24.590                                                                             61.220                                                                             20.349                                                                             1.00                                                                              41.20            1DLC 618                    ATOM  495                                                                               CG TYR 124                                                                               23.913                                                                             61.533                                                                             21.674                                                                             1.00                                                                              45.22            1DLC 619                    ATOM  496                                                                               CD1                                                                               TYR 124                                                                               24.551                                                                             62.322                                                                             22.634                                                                             1.00                                                                              46.84            1DLC 620                    ATOM  497                                                                               CD2                                                                               TYR 124                                                                               22.643                                                                             61.038                                                                             21.972                                                                             1.00                                                                              46.22            1DLC 621                    ATOM  498                                                                               CE1                                                                               TYR 124                                                                               23.948                                                                             62.606                                                                             23.856                                                                             1.00                                                                              48.97            1DLC 622                    ATOM  499                                                                               CE2                                                                               TYR 124                                                                               22.025                                                                             61.320                                                                             23.199                                                                             1.00                                                                              48.29            1DLC 623                    ATOM  500                                                                               CZ TYR 124                                                                               22.688                                                                             62.105                                                                             24.135                                                                             1.00                                                                              50.39            1DLC 624                    ATOM  501                                                                               OH TYR 124                                                                               22.109                                                                             62.394                                                                             25.353                                                                             1.00                                                                              51.34            1DLC 625                    ATOM  502                                                                               N  ALA 125                                                                               25.775                                                                             59.545                                                                             22.738                                                                             1.00                                                                              38.41            1DLC 626                    ATOM  503                                                                               CA ALA 125                                                                               26.442                                                                             59.468                                                                             24.033                                                                             1.00                                                                              36.03            1DLC 627                    ATOM  504                                                                               C  ALA 125                                                                               27.544                                                                             58.411                                                                             24.021                                                                             1.00                                                                              35.18            1DLC 628                    ATOM  505                                                                               O  ALA 125                                                                               28.569                                                                             58.567                                                                             24.676                                                                             1.00                                                                              36.66            1DLC 629                    ATOM  506                                                                               CB ALA 125                                                                               25.429                                                                             59.169                                                                             25.127                                                                             1.00                                                                              36.03            1DLC 630                    ATOM  507                                                                               N  LYS 126                                                                               27.332                                                                             57.349                                                                             23.253                                                                             1.00                                                                              34.60            1DLC 631                    ATOM  508                                                                               CA LYS 126                                                                               28.300                                                                             56.259                                                                             23.132                                                                             1.00                                                                              35.76            1DLC 632                    ATOM  509                                                                               C  LYS 126                                                                               29.519                                                                             56.726                                                                             22.325                                                                             1.00                                                                              36.46            1DLC 633                    ATOM  510                                                                               O  LYS 126                                                                               30.669                                                                             56.513                                                                             22.719                                                                             1.00                                                                              36.95            1DLC 634                    ATOM  511                                                                               CB LYS 126                                                                               27.621                                                                             55.071                                                                             22.445                                                                             1.00                                                                              38.14            1DLC 635                    ATOM  512                                                                               CG LYS 126                                                                               28.249                                                                             53.708                                                                             22.678                                                                             1.00                                                                              39.63            1DLC 636                    ATOM  513                                                                               CD LYS 126                                                                               27.180                                                                             52.619                                                                             22.514                                                                             1.00                                                                              43.72            1DLC 637                    ATOM  514                                                                               CE LYS 126                                                                               27.763                                                                             51.210                                                                             22.428                                                                             1.00                                                                              45.37            1DLC 638                    ATOM  515                                                                               NZ LYS 126                                                                               28.477                                                                             50.752                                                                             23.655                                                                             1.00                                                                              48.58            1DLC 639                    ATOM  516                                                                               N  ASN 127                                                                               29.258                                                                             57.409                                                                             21.215                                                                             1.00                                                                              38.31            1DLC 640                    ATOM  517                                                                               CA ASN 127                                                                               30.321                                                                             57.915                                                                             20.353                                                                             1.00                                                                              39.87            1DLC 641                    ATOM  518                                                                               C  ASN 127                                                                               31.184                                                                             58.966                                                                             21.032                                                                             1.00                                                                              38.46            1DLC 642                    ATOM  519                                                                               O  ASN 127                                                                               32.404                                                                             58.932                                                                             20.904                                                                             1.00                                                                              39.48            1DLC 643                    ATOM  520                                                                               CB ASN 127                                                                               29.749                                                                             58.479                                                                             19.051                                                                             1.00                                                                              42.71            1DLC 644                    ATOM  521                                                                               CG ASN 127                                                                               29.088                                                                             57.415                                                                             18.198                                                                             1.00                                                                              46.61            1DLC 645                    ATOM  522                                                                               OD1                                                                               ASN 127                                                                               28.081                                                                             57.675                                                                             17.543                                                                             1.00                                                                              52.98            1DLC 646                    ATOM  523                                                                               ND2                                                                               ASN 127                                                                               29.648                                                                             56.209                                                                             18.198                                                                             1.00                                                                              42.83            1DLC 647                    ATOM  524                                                                               N  LYS 128                                                                               30.563                                                                             59.911                                                                             21.733                                                                             1.00                                                                              38.09            1DLC 648                    ATOM  525                                                                               CA LYS 128                                                                               31.349                                                                             60.929                                                                             22.415                                                                             1.00                                                                              39.08            1DLC 649                    ATOM  526                                                                               C  LYS 128                                                                               32.237                                                                             60.300                                                                             23.472                                                                             1.00                                                                              38.69            1DLC 650                    ATOM  527                                                                               O  LYS 128                                                                               33.415                                                                             60.642                                                                             23.577                                                                             1.00                                                                              42.45            1DLC 651                    ATOM  528                                                                               CB LYS 128                                                                               30.495                                                                             62.006                                                                             23.071                                                                             1.00                                                                              41.87            1DLC 652                    ATOM  529                                                                               CG LYS 128                                                                               31.380                                                                             62.951                                                                             23.880                                                                             1.00                                                                              46.08            1DLC 653                    ATOM  530                                                                               CD LYS 128                                                                               30.689                                                                             64.221                                                                             24.295                                                                             1.00                                                                              49.62            1DLC 654                    ATOM  531                                                                               CE LYS 128                                                                               31.726                                                                             65.260                                                                             24.666                                                                             1.00                                                                              47.91            1DLC 655                    ATOM  532                                                                               NZ LYS 128                                                                               32.699                                                                             65.442                                                                             23.547                                                                             1.00                                                                              50.26            1DLC 656                    ATOM  533                                                                               N  ALA 129                                                                               31.668                                                                             59.381                                                                             24.248                                                                             1.00                                                                              34.82            1DLC 657                    ATOM  534                                                                               CA ALA 129                                                                               32.420                                                                             58.691                                                                             25.287                                                                             1.00                                                                              33.08            1DLC 658                    ATOM  535                                                                               C  ALA 129                                                                               33.673                                                                             58.059                                                                             24.676                                                                             1.00                                                                              32.09            1DLC 659                    ATOM  536                                                                               O  ALA 129                                                                               34.793                                                                             58.278                                                                             25.150                                                                             1.00                                                                              31.18            1DLC 660                    ATOM  537                                                                               CB ALA 129                                                                               31.552                                                                             57.628                                                                             25.953                                                                             1.00                                                                              30.56            1DLC 661                    ATOM  538                                                                               N  LEU 130                                                                               33.486                                                                             57.327                                                                             23.582                                                                             1.00                                                                              32.74            1DLC 662                    ATOM  539                                                                               CA LEU 130                                                                               34.600                                                                             56.673                                                                             22.903                                                                             1.00                                                                              30.32            1DLC 663                    ATOM  540                                                                               C  LEU 130                                                                               35.640                                                                             57.669                                                                             22.407                                                                             1.00                                                                              31.27            1DLC 664                    ATOM  541                                                                               O  LEU 130                                                                               36.849                                                                             57.410                                                                             22.474                                                                             1.00                                                                              31.13            1DLC 665                    ATOM  542                                                                               CB LEU 130                                                                               34.081                                                                             55.813                                                                             21.755                                                                             1.00                                                                              29.76            1DLC 666                    ATOM  543                                                                               CG LEU 130                                                                               33.435                                                                             54.489                                                                             22.182                                                                             1.00                                                                              30.23            1DLC 667                    ATOM  544                                                                               CD1                                                                               LEU 130                                                                               32.732                                                                             53.832                                                                             21.000                                                                             1.00                                                                              30.62            1DLC 668                    ATOM  545                                                                               CD2                                                                               LEU 130                                                                               34.499                                                                             53.559                                                                             22.764                                                                             1.00                                                                              26.30            1DLC 669                    ATOM  546                                                                               N  ALA 131                                                                               35.166                                                                             58.829                                                                             21.960                                                                             1.00                                                                              32.32            1DLC 670                    ATOM  547                                                                               CA ALA 131                                                                               36.046                                                                             59.883                                                                             21.460                                                                             1.00                                                                              32.99            1DLC 671                    ATOM  548                                                                               C  ALA 131                                                                               36.929                                                                             60.416                                                                             22.584                                                                             1.00                                                                              34.16            1DLC 672                    ATOM  549                                                                               O  ALA 131                                                                               38.145                                                                             60.515                                                                             22.427                                                                             1.00                                                                              37.33            1DLC 673                    ATOM  550                                                                               CB ALA 131                                                                               35.229                                                                             61.008                                                                             20.847                                                                             1.00                                                                              31.10            1DLC 674                    ATOM  551                                                                               N  GLU 132                                                                               36.318                                                                             60.735                                                                             23.725                                                                             1.00                                                                              34.14            1DLC 675                    ATOM  552                                                                               CA GLU 132                                                                               37.054                                                                             61.234                                                                             24.891                                                                             1.00                                                                              31.85            1DLC 676                    ATOM  553                                                                               C  GLU 132                                                                               38.128                                                                             60.232                                                                             25.296                                                                             1.00                                                                              30.73            1DLC 677                    ATOM  554                                                                               O  GLU 132                                                                               39.279                                                                             60.598                                                                             25.536                                                                             1.00                                                                              30.23            1DLC 678                    ATOM  555                                                                               CB GLU 132                                                                               36.109                                                                             61.439                                                                             26.072                                                                             1.00                                                                              28.74            1DLC 679                    ATOM  556                                                                               CG GLU 132                                                                               35.049                                                                             62.483                                                                             25.842                                                                             1.00                                                                              33.99            1DLC 680                    ATOM  557                                                                               CD GLU 132                                                                               35.617                                                                             63.884                                                                             25.722                                                                             1.00                                                                              40.12            1DLC 681                    ATOM  558                                                                               OE1                                                                               GLU 132                                                                               36.787                                                                             64.104                                                                             26.104                                                                             1.00                                                                              41.36            1DLC 682                    ATOM  559                                                                               OE2                                                                               GLU 132                                                                               34.882                                                                             64.778                                                                             25.251                                                                             1.00                                                                              46.52            1DLC 683                    ATOM  560                                                                               N  LEU 133                                                                               37.739                                                                             58.961                                                                             25.320                                                                             1.00                                                                              31.50            1DLC 684                    ATOM  561                                                                               CA LEU 133                                                                               38.627                                                                             57.866                                                                             25.692                                                                             1.00                                                                              32.60            1DLC 685                    ATOM  562                                                                               C  LEU 133                                                                               39.845                                                                             57.712                                                                             24.785                                                                             1.00                                                                              34.20            1DLC 686                    ATOM  563                                                                               O  LEU 133                                                                               40.930                                                                             57.388                                                                             25.261                                                                             1.00                                                                              34.43            1DLC 687                    ATOM  564                                                                               CB LEU 133                                                                               37.833                                                                             56.561                                                                             25.795                                                                             1.00                                                                              30.47            1DLC 688                    ATOM  565                                                                               CG LEU 133                                                                               36.896                                                                             56.525                                                                             27.009                                                                             1.00                                                                              30.33            1DLC 689                    ATOM  566                                                                               CD1                                                                               LEU 133                                                                               35.766                                                                             55.538                                                                             26.796                                                                             1.00                                                                              26.58            1DLC 690                    ATOM  567                                                                               CD2                                                                               LEU 133                                                                               37.693                                                                             56.206                                                                             28.271                                                                             1.00                                                                              24.25            1DLC 691                    ATOM  568                                                                               N  GLN 134                                                                               39.679                                                                             57.952                                                                             23.486                                                                             1.00                                                                              37.63            1DLC 692                    ATOM  569                                                                               CA GLN 134                                                                               40.812                                                                             57.866                                                                             22.564                                                                             1.00                                                                              39.17            1DLC 693                    ATOM  570                                                                               C  GLN 134                                                                               41.814                                                                             58.949                                                                             22.945                                                                             1.00                                                                              36.45            1DLC 694                    ATOM  571                                                                               O  GLN 134                                                                               43.015                                                                             58.701                                                                             23.038                                                                             1.00                                                                              38.66            1DLC 695                    ATOM  572                                                                               CB GLN 134                                                                               40.363                                                                             58.083                                                                             21.119                                                                             1.00                                                                              47.75            1DLC 696                    ATOM  573                                                                               CG GLN 134                                                                               39.344                                                                             57.074                                                                             20.614                                                                             1.00                                                                              61.82            1DLC 697                    ATOM  574                                                                               CD GLN 134                                                                               39.792                                                                             55.634                                                                             20.821                                                                             1.00                                                                              70.74            1DLC 698                    ATOM  575                                                                               OE1                                                                               GLN 134                                                                               40.513                                                                             55.060                                                                             19.996                                                                             1.00                                                                              73.31            1DLC 699                    ATOM  576                                                                               NE2                                                                               GLN 134                                                                               39.359                                                                             55.041                                                                             21.928                                                                             1.00                                                                              73.58            1DLC 700                    ATOM  577                                                                               N  GLY 135                                                                               41.301                                                                             60.147                                                                             23.207                                                                             1.00                                                                              32.99            1DLC 701                    ATOM  578                                                                               CA GLY 135                                                                               42.156                                                                             61.255                                                                             23.599                                                                             1.00                                                                              32.54            1DLC 702                    ATOM  579                                                                               C  GLY 135                                                                               42.871                                                                             61.024                                                                             24.921                                                                             1.00                                                                              32.17            1DLC 703                    ATOM  580                                                                               O  GLY 135                                                                               44.039                                                                             61.378                                                                             25.080                                                                             1.00                                                                              34.18            1DLC 704                    ATOM  581                                                                               N  LEU 136                                                                               42.160                                                                             60.445                                                                             25.881                                                                             1.00                                                                              30.44            1DLC 705                    ATOM  582                                                                               CA LEU 136                                                                               42.729                                                                             60.151                                                                             27.190                                                                             1.00                                                                              30.39            1DLC 706                    ATOM  583                                                                               C  LEU 136                                                                               43.818                                                                             59.084                                                                             27.081                                                                             1.00                                                                              31.99            1DLC 707                    ATOM  584                                                                               O  LEU 136                                                                               44.794                                                                             59.096                                                                             27.828                                                                             1.00                                                                              32.33            1DLC 708                    ATOM  585                                                                               CB LEU 136                                                                               41.637                                                                             59.668                                                                             28.141                                                                             1.00                                                                              28.24            1DLC 709                    ATOM  586                                                                               CG LEU 136                                                                               40.578                                                                             60.685                                                                             28.552                                                                             1.00                                                                              25.44            1DLC 710                    ATOM  587                                                                               CD1                                                                               LEU 136                                                                               39.432                                                                             59.977                                                                             29.232                                                                             1.00                                                                              20.57            1DLC 711                    ATOM  588                                                                               CD2                                                                               LEU 136                                                                               41.202                                                                             61.714                                                                             29.468                                                                             1.00                                                                              23.94            1DLC 712                    ATOM  589                                                                               N  GLN 137                                                                               43.644                                                                             58.159                                                                             26.144                                                                             1.00                                                                              34.65            1DLC 713                    ATOM  590                                                                               CA GLN 137                                                                               44.612                                                                             57.091                                                                             25.937                                                                             1.00                                                                              36.83            1DLC 714                    ATOM  591                                                                               C  GLN 137                                                                               45.968                                                                             57.692                                                                             25.570                                                                             1.00                                                                              37.51            1DLC 715                    ATOM  592                                                                               O  GLN 137                                                                               46.980                                                                             57.410                                                                             26.221                                                                             1.00                                                                              35.29            1DLC 716                    ATOM  593                                                                               CB GLN 137                                                                               44.138                                                                             56.152                                                                             24.829                                                                             1.00                                                                              39.14            1DLC 717                    ATOM  594                                                                               CG GLN 137                                                                               44.992                                                                             54.905                                                                             24.664                                                                             1.00                                                                              43.17            1DLC 718                    ATOM  595                                                                               CD GLN 137                                                                               44.607                                                                             54.094                                                                             23.445                                                                             1.00                                                                              45.19            1DLC 719                    ATOM  596                                                                               OE1                                                                               GLN 137                                                                               43.460                                                                             54.127                                                                             22.989                                                                             1.00                                                                              47.54            1DLC 720                    ATOM  597                                                                               NE2                                                                               GLN 137                                                                               45.562                                                                             53.355                                                                             22.911                                                                             1.00                                                                              46.02            1DLC 721                    ATOM  598                                                                               N  ASN 138                                                                               45.970                                                                             58.561                                                                             24.561                                                                             1.00                                                                              37.22            1DLC 722                    ATOM  599                                                                               CA ASN 138                                                                               47.195                                                                             59.219                                                                             24.119                                                                             1.00                                                                              39.24            1DLC 723                    ATOM  600                                                                               C  ASN 138                                                                               47.872                                                                             59.935                                                                             25.281                                                                             1.00                                                                              36.46            1DLC 724                    ATOM  601                                                                               O  ASN 138                                                                               49.078                                                                             59.799                                                                             25.478                                                                             1.00                                                                              36.61            1DLC 725                    ATOM  602                                                                               CB ASN 138                                                                               46.898                                                                             60.203                                                                             22.989                                                                             1.00                                                                              43.17            1DLC 726                    ATOM  603                                                                               CG ASN 138                                                                               46.319                                                                             59.516                                                                             21.764                                                                             1.00                                                                              50.90            1DLC 727                    ATOM  604                                                                               OD1                                                                               ASN 138                                                                               46.471                                                                             58.303                                                                             21.580                                                                             1.00                                                                              54.32            1DLC 728                    ATOM  605                                                                               ND2                                                                               ASN 138                                                                               45.640                                                                             60.283                                                                             20.923                                                                             1.00                                                                              51.88            1DLC 729                    ATOM  606                                                                               N  ASN 139                                                                               47.079                                                                             60.639                                                                             26.085                                                                             1.00                                                                              33.80            1DLC 730                    ATOM  607                                                                               CA ASN 139                                                                               47.601                                                                             61.358                                                                             27.247                                                                             1.00                                                                              31.83            1DLC 731                    ATOM  608                                                                               C  ASN 139                                                                               48.263                                                                             60.412                                                                             28.233                                                                             1.00                                                                              30.17            1DLC 732                    ATOM  609                                                                               O  ASN 139                                                                               49.350                                                                             60.691                                                                             28.733                                                                             1.00                                                                              29.01            1DLC 733                    ATOM  610                                                                               CB ASN 139                                                                               46.485                                                                             62.115                                                                             27.969                                                                             1.00                                                                              32.59            1DLC 734                    ATOM  611                                                                               CG ASN 139                                                                               45.928                                                                             63.270                                                                             27.154                                                                             1.00                                                                              37.15            1DLC 735                    ATOM  612                                                                               OD1                                                                               ASN 139                                                                               45.081                                                                             64.014                                                                             27.634                                                                             1.00                                                                              42.84            1DLC 736                    ATOM  613                                                                               ND2                                                                               ASN 139                                                                               46.392                                                                             63.425                                                                             25.926                                                                             1.00                                                                              35.37            1DLC 737                    ATOM  614                                                                               N  VAL 140                                                                               47.611                                                                             59.281                                                                             28.493                                                                             1.00                                                                              30.85            1DLC 738                    ATOM  615                                                                               CA VAL 140                                                                               48.141                                                                             58.301                                                                             29.436                                                                             1.00                                                                              35.20            1DLC 739                    ATOM  616                                                                               C  VAL 140                                                                               49.421                                                                             57.652                                                                             28.911                                                                             1.00                                                                              35.66            1DLC 740                    ATOM  617                                                                               O  VAL 140                                                                               50.406                                                                             57.516                                                                             29.645                                                                             1.00                                                                              36.30            1DLC 741                    ATOM  618                                                                               CB VAL 140                                                                               47.097                                                                             57.202                                                                             29.794                                                                             1.00                                                                              33.23            1DLC 742                    ATOM  619                                                                               CG1                                                                               VAL 140                                                                               47.596                                                                             56.370                                                                             30.970                                                                             1.00                                                                              30.81            1DLC 743                    ATOM  620                                                                               CG2                                                                               VAL 140                                                                               45.772                                                                             57.829                                                                             30.158                                                                             1.00                                                                              34.27            1DLC 744                    ATOM  621                                                                               N  GLU 141                                                                               49.412                                                                             57.280                                                                             27.635                                                                             1.00                                                                              36.48            1DLC 745                    ATOM  622                                                                               CA GLU 141                                                                               50.575                                                                             56.655                                                                             27.016                                                                             1.00                                                                              37.87            1DLC 746                    ATOM  623                                                                               C  GLU 141                                                                               51.777                                                                             57.606                                                                             26.989                                                                             1.00                                                                              36.94            1DLC 747                    ATOM  624                                                                               O  GLU 141                                                                               52.868                                                                             57.250                                                                             27.451                                                                             1.00                                                                              36.22            1DLC 748                    ATOM  625                                                                               CB GLU 141                                                                               50.223                                                                             56.142                                                                             25.613                                                                             1.00                                                                              39.44            1DLC 749                    ATOM  626                                                                               CG GLU 141                                                                               49.194                                                                             55.010                                                                             25.647                                                                             1.00                                                                              46.15            1DLC 750                    ATOM  627                                                                               CD GLU 141                                                                               48.815                                                                             54.460                                                                             24.273                                                                             1.00                                                                              50.50            1DLC 751                    ATOM  628                                                                               OE1                                                                               GLU 141                                                                               48.932                                                                             55.189                                                                             23.255                                                                             1.00                                                                              48.49            1DLC 752                    ATOM  629                                                                               OE2                                                                               GLU 141                                                                               48.377                                                                             53.286                                                                             24.225                                                                             1.00                                                                              52.05            1DLC 753                    ATOM  630                                                                               N  ASP 142                                                                               51.562                                                                             58.831                                                                             26.514                                                                             1.00                                                                              34.71            1DLC 754                    ATOM  631                                                                               CA ASP 142                                                                               52.633                                                                             59.819                                                                             26.462                                                                             1.00                                                                              33.53            1DLC 755                    ATOM  632                                                                               C  ASP 142                                                                               53.214                                                                             59.998                                                                             27.849                                                                             1.00                                                                              32.09            1DLC 756                    ATOM  633                                                                               O  ASP 142                                                                               54.434                                                                             60.066                                                                             28.019                                                                             1.00                                                                              33.76            1DLC 757                    ATOM  634                                                                               CB ASP 142                                                                               52.124                                                                             61.168                                                                             25.943                                                                             1.00                                                                              34.47            1DLC 758                    ATOM  635                                                                               CG ASP 142                                                                               51.806                                                                             61.150                                                                             24.452                                                                             1.00                                                                              37.60            1DLC 759                    ATOM  636                                                                               OD1                                                                               ASP 142                                                                               52.150                                                                             60.158                                                                             23.765                                                                             1.00                                                                              37.44            1DLC 760                    ATOM  637                                                                               OD2                                                                               ASP 142                                                                               51.204                                                                             62.135                                                                             23.967                                                                             1.00                                                                              37.76            1DLC 761                    ATOM  638                                                                               N  TYR 143                                                                               52.336                                                                             60.020                                                                             28.847                                                                             1.00                                                                              29.85            1DLC 762                    ATOM  639                                                                               CA TYR 143                                                                               52.770                                                                             60.180                                                                             30.228                                                                             1.00                                                                              31.12            1DLC 763                    ATOM  640                                                                               C  TYR 143                                                                               53.619                                                                             59.010                                                                             30.741                                                                             1.00                                                                              31.96            1DLC 764                    ATOM  641                                                                               O  TYR 143                                                                               54.655                                                                             59.221                                                                             31.373                                                                             1.00                                                                              29.33            1DLC 765                    ATOM  642                                                                               CB TYR 143                                                                               51.569                                                                             60.394                                                                             31.162                                                                             1.00                                                                              29.85            1DLC 766                    ATOM  643                                                                               CG TYR 143                                                                               51.951                                                                             60.326                                                                             32.627                                                                             1.00                                                                              28.37            1DLC 767                    ATOM  644                                                                               CD1                                                                               TYR 143                                                                               52.705                                                                             61.347                                                                             33.220                                                                             1.00                                                                              27.51            1DLC 768                    ATOM  645                                                                               CD2                                                                               TYR 143                                                                               51.631                                                                             59.207                                                                             33.397                                                                             1.00                                                                              26.05            1DLC 769                    ATOM  646                                                                               CE1                                                                               TYR 143                                                                               53.135                                                                             61.251                                                                             34.532                                                                             1.00                                                                              25.76            1DLC 770                    ATOM  647                                                                               CE2                                                                               TYR 143                                                                               52.057                                                                             59.101                                                                             34.716                                                                             1.00                                                                              26.39            1DLC 771                    ATOM  648                                                                               CZ TYR 143                                                                               52.809                                                                             60.124                                                                             35.274                                                                             1.00                                                                              27.82            1DLC 772                    ATOM  649                                                                               OH TYR 143                                                                               53.252                                                                             60.012                                                                             36.569                                                                             1.00                                                                              30.91            1DLC 773                    ATOM  650                                                                               N  VAL 144                                                                               53.156                                                                             57.784                                                                             30.499                                                                             1.00                                                                              34.31            1DLC 774                    ATOM  651                                                                               CA VAL 144                                                                               53.863                                                                             56.587                                                                             30.951                                                                             1.00                                                                              35.26            1DLC 775                    ATOM  652                                                                               C  VAL 144                                                                               55.239                                                                             56.440                                                                             30.316                                                                             1.00                                                                              36.56            1DLC 776                    ATOM  653                                                                               O  VAL 144                                                                               56.205                                                                             56.111                                                                             31.008                                                                             1.00                                                                              37.15            1DLC 777                    ATOM  654                                                                               CB VAL 144                                                                               53.033                                                                             55.298                                                                             30.720                                                                             1.00                                                                              35.68            1DLC 778                    ATOM  655                                                                               CG1                                                                               VAL 144                                                                               53.836                                                                             54.065                                                                             31.131                                                                             1.00                                                                              32.11            1DLC 779                    ATOM  656                                                                               CG2                                                                               VAL 144                                                                               51.747                                                                             55.363                                                                             31.529                                                                             1.00                                                                              33.51            1DLC 780                    ATOM  657                                                                               N  SER 145                                                                               55.341                                                                             56.699                                                                             29.011                                                                             1.00                                                                              37.88            1DLC 781                    ATOM  658                                                                               CA SER 145                                                                               56.642                                                                             56.601                                                                             28.332                                                                             1.00                                                                              38.87            1DLC 782                    ATOM  659                                                                               C  SER 145                                                                               57.635                                                                             57.535                                                                             29.031                                                                             1.00                                                                              34.99            1DLC 783                    ATOM  660                                                                               O  SER 145                                                                               58.720                                                                             57.117                                                                             29.437                                                                             1.00                                                                              38.01            1DLC 784                    ATOM  661                                                                               CB SER 145                                                                               56.534                                                                             56.951                                                                             26.834                                                                             1.00                                                                              39.91            1DLC 785                    ATOM  662                                                                               OG SER 145                                                                               56.444                                                                             58.350                                                                             26.596                                                                             1.00                                                                              46.34            1DLC 786                    ATOM  663                                                                               N  ALA 146                                                                               57.207                                                                             58.772                                                                             29.258                                                                             1.00                                                                              30.82            1DLC 787                    ATOM  664                                                                               CA ALA 146                                                                               58.031                                                                             59.761                                                                             29.931                                                                             1.00                                                                              30.30            1DLC 788                    ATOM  665                                                                               C  ALA 146                                                                               58.359                                                                             59.340                                                                             31.364                                                                             1.00                                                                              31.85            1DLC 789                    ATOM  666                                                                               O  ALA 146                                                                               59.509                                                                             59.426                                                                             31.790                                                                             1.00                                                                              35.45            1DLC 790                    ATOM  667                                                                               CB ALA 146                                                                               57.345                                                                             61.123                                                                             29.915                                                                             1.00                                                                              27.74            1DLC 791                    ATOM  668                                                                               N  LEU 147                                                                               57.362                                                                             58.863                                                                             32.103                                                                             1.00                                                                              32.59            1DLC 792                    ATOM  669                                                                               CA LEU 147                                                                               57.595                                                                             58.432                                                                             33.477                                                                             1.00                                                                              32.81            1DLC 793                    ATOM  670                                                                               C  LEU 147                                                                               58.607                                                                             57.297                                                                             33.490                                                                             1.00                                                                              33.53            1DLC 794                    ATOM  671                                                                               O  LEU 147                                                                               59.496                                                                             57.252                                                                             34.337                                                                             1.00                                                                              35.25            1DLC 795                    ATOM  672                                                                               CB LEU 147                                                                               56.300                                                                             57.968                                                                             34.150                                                                             1.00                                                                              32.39            1DLC 796                    ATOM  673                                                                               CG LEU 147                                                                               56.502                                                                             57.425                                                                             35.574                                                                             1.00                                                                              30.47            1DLC 797                    ATOM  674                                                                               CD1                                                                               LEU 147                                                                               57.043                                                                             58.522                                                                             36.480                                                                             1.00                                                                              29.60            1DLC 798                    ATOM  675                                                                               CD2                                                                               LEU 147                                                                               55.204                                                                             56.866                                                                             36.129                                                                             1.00                                                                              32.87            1DLC 799                    ATOM  676                                                                               N  SER 148                                                                               58.489                                                                             56.399                                                                             32.523                                                                             1.00                                                                              34.54            1DLC 800                    ATOM  677                                                                               CA SER 148                                                                               59.400                                                                             55.270                                                                             32.416                                                                             1.00                                                                              38.01            1DLC 801                    ATOM  678                                                                               C  SER 148                                                                               60.844                                                                             55.766                                                                             32.240                                                                             1.00                                                                              38.45            1DLC 802                    ATOM  679                                                                               O  SER 148                                                                               61.767                                                                             55.311                                                                             32.931                                                                             1.00                                                                              38.67            1DLC 803                    ATOM  680                                                                               CB SER 148                                                                               58.993                                                                             54.388                                                                             31.237                                                                             1.00                                                                              41.71            1DLC 804                    ATOM  681                                                                               OG SER 148                                                                               59.823                                                                             53.242                                                                             31.146                                                                             1.00                                                                              52.18            1DLC 805                    ATOM  682                                                                               N  SER 149                                                                               61.031                                                                             56.724                                                                             31.338                                                                             1.00                                                                              37.6D            1DLC 806                    ATOM  683                                                                               CA SER 149                                                                               62.355                                                                             57.292                                                                             31.098                                                                             1.00                                                                              36.97            1DLC 807                    ATOM  684                                                                               C  SER 149                                                                               62.888                                                                             57.943                                                                             32.369                                                                             1.00                                                                              36.69            1DLC 808                    ATOM  685                                                                               O  SER 149                                                                               64.015                                                                             57.693                                                                             32.768                                                                             1.00                                                                              40.93            1DLC 809                    ATOM  686                                                                               CB SER 149                                                                               62.317                                                                             58.329                                                                             29.968                                                                             1.00                                                                              40.27            1DLC 810                    ATOM  687                                                                               OG SER 149                                                                               61.927                                                                             57.753                                                                             28.725                                                                             1.00                                                                              42.78            1DLC 811                    ATOM  688                                                                               N  TRP 150                                                                               62.057                                                                             58.739                                                                             33.030                                                                             1.00                                                                              36.23            1DLC 812                    ATOM  689                                                                               CA TRP 150                                                                               62.458                                                                             59.417                                                                             34.260                                                                             1.00                                                                              35.43            1DLC 813                    ATOM  69D                                                                               C  TRP 150                                                                               62.997                                                                             58.455                                                                             35.332                                                                             1.00                                                                              40.04            1DLC 814                    ATOM  691                                                                               O  TRP 150                                                                               64.055                                                                             58.695                                                                             35.912                                                                             1.00                                                                              41.77            1DLC 815                    ATOM  692                                                                               CB TRP 150                                                                               61.286                                                                             60.237                                                                             34.813                                                                             1.00                                                                              29.63            1DLC 816                    ATOM  693                                                                               CG TRP 150                                                                               61.601                                                                             60.987                                                                             36.069                                                                             1.00                                                                              25.67            1DLC 817                    ATOM  694                                                                               CD1                                                                               TRP 150                                                                               61.510                                                                             60.519                                                                             37.348                                                                             1.00                                                                              25.82            1DLC 818                    ATOM  695                                                                               CD2                                                                               TRP 150                                                                               62.068                                                                             62.339                                                                             36.170                                                                             1.00                                                                              26.03            1DLC 819                    ATOM  696                                                                               NE1                                                                               TRP 150                                                                               61.895                                                                             61.491                                                                             38.236                                                                             1.00                                                                              23.31            1DLC 820                    ATOM  697                                                                               CE2                                                                               TRP 150                                                                               62.241                                                                             62.619                                                                             37.541                                                                             1.00                                                                              22.80            1DLC 821                    ATOM  698                                                                               CE3                                                                               TRP 150                                                                               62.354                                                                             63.342                                                                             35.235                                                                             1.00                                                                              25.92            1DLC 822                    ATOM  699                                                                               CZ2                                                                               TRP 150                                                                               62.687                                                                             63.857                                                                             38.001                                                                             1.00                                                                              25.85            1DLC 823                    ATOM  700                                                                               CZ3                                                                               TRP 150                                                                               62.797                                                                             64.578                                                                             35.696                                                                             1.00                                                                              26.29            1DLC 824                    ATOM  701                                                                               CH2                                                                               TRP 150                                                                               62.958                                                                             64.822                                                                             37.065                                                                             1.00                                                                              25.55            1DLC 825                    ATOM  702                                                                               N  GLN 151                                                                               62.263                                                                             57.378                                                                             35.602                                                                             1.00                                                                              44.57            1DLC 826                    ATOM  703                                                                               CA GLN 151                                                                               62.687                                                                             56.396                                                                             36.602                                                                             1.00                                                                              48.28            1DLC 827                    ATOM  704                                                                               C  GLN 151                                                                               64.013                                                                             55.747                                                                             36.227                                                                             1.00                                                                              50.95            1DLC 828                    ATOM  705                                                                               O  GLN 151                                                                               64.902                                                                             55.586                                                                             37.061                                                                             1.00                                                                              50.37            1DLC 829                    ATOM  706                                                                               CB GLN 151                                                                               61.627                                                                             55.304                                                                             36.763                                                                             1.00                                                                              48.02            1DLC 830                    ATOM  707                                                                               CG GLN 151                                                                               60.751                                                                             55.460                                                                             37.990                                                                             1.00                                                                              51.89            1DLC 831                    ATOM  708                                                                               CD GLN 151                                                                               61.539                                                                             55.351                                                                             39.287                                                                             1.00                                                                              55.39            1DLC 832                    ATOM  709                                                                               OE1                                                                               GLN 151                                                                               62.270                                                                             54.382                                                                             39.506                                                                             1.00                                                                              56.87            1DLC 833                    ATOM  710                                                                               NE2                                                                               GLN 151                                                                               61.397                                                                             56.345                                                                             40.153                                                                             1.00                                                                              54.44            1DLC 834                    ATOM  711                                                                               N  LYS 152                                                                               64.116                                                                             55.379                                                                             34.954                                                                             1.00                                                                              55.10            1DLC 835                    ATOM  712                                                                               CA LYS 152                                                                               65.296                                                                             54.729                                                                             34.388                                                                             1.00                                                                              59.98            1DLC 836                    ATOM  713                                                                               C  LYS 152                                                                               66.545                                                                             55.624                                                                             34.404                                                                             1.00                                                                              62.63            1DLC 837                    ATOM  714                                                                               O  LYS 152                                                                               67.645                                                                             55.172                                                                             34.734                                                                             1.00                                                                              63.39            1DLC 838                    ATOM  715                                                                               CB LYS 152                                                                               64.974                                                                             54.300                                                                             32.953                                                                             1.00                                                                              59.73            1DLC 839                    ATOM  716                                                                               CG LYS 152                                                                               65.960                                                                             53.357                                                                             32.301                                                                             1.00                                                                              62.85            1DLC 840                    ATOM  717                                                                               CD LYS 152                                                                               65.440                                                                             52.978                                                                             30.920                                                                             1.00                                                                              68.02            1DLC 841                    ATOM  718                                                                               CE LYS 152                                                                               66.367                                                                             52.023                                                                             30.168                                                                             1.00                                                                              69.39            1DLC 842                    ATOM  719                                                                               NZ LYS 152                                                                               65.842                                                                             51.764                                                                             28.785                                                                             1.00                                                                              68.57            1DLC 843                    ATOM  720                                                                               N  ASN 153                                                                               66.367                                                                             56.891                                                                             34.044                                                                             1.00                                                                              64.53            1DLC 844                    ATOM  721                                                                               CA ASN 153                                                                               67.472                                                                             57.839                                                                             34.003                                                                             1.00                                                                              66.57            1DLC 845                    ATOM  722                                                                               C  ASN 153                                                                               67.961                                                                             58.271                                                                             35.384                                                                             1.00                                                                              68.87            1DLC 846                    ATOM  723                                                                               O  ASN 153                                                                               67.165                                                                             58.560                                                                             36.283                                                                             1.00                                                                              68.08            1DLC 847                    ATOM  724                                                                               CB ASN 153                                                                               67.097                                                                             59.057                                                                             33.153                                                                             1.00                                                                              67.50            1DLC 848                    ATOM  725                                                                               CG ASN 153                                                                               67.050                                                                             58.743                                                                             31.656                                                                             1.00                                                                              69.77            1DLC 849                    ATOM  726                                                                               DD1                                                                               ASN 153                                                                               66.936                                                                             59.649                                                                             30.831                                                                             1.00                                                                              71.11            1DLC 850                    ATOM  727                                                                               ND2                                                                               ASN 153                                                                               67.150                                                                             57.464                                                                             31.300                                                                             1.00                                                                              68.53            1DLC 8S1                    ATOM  728                                                                               N  PRO 154                                                                               69.294                                                                             58.308                                                                             35.570                                                                             1.00                                                                              71.40            1DLC 852                    ATOM  729                                                                               CA PRO 154                                                                               69.934                                                                             58.697                                                                             36.830                                                                             1.00                                                                              71.82            1DLC 853                    ATOM  730                                                                               C  PRO 154                                                                               69.610                                                                             60.141                                                                             37.198                                                                             1.00                                                                              72.79            1DLC 854                    ATOM  731                                                                               O  PRO 154                                                                               69.311                                                                             60.961                                                                             36.324                                                                             1.00                                                                              73.90            1DLC 855                    ATOM  732                                                                               CB PRO 154                                                                               71.424                                                                             58.545                                                                             36.516                                                                             1.00                                                                              71.42            1DLC 856                    ATOM  733                                                                               CG PRO 154                                                                               71.450                                                                             57.498                                                                             35.443                                                                             1.00                                                                              71.51            1DLC 857                    ATOM  734                                                                               CD PRO 154                                                                               70.312                                                                             57.939                                                                             34.570                                                                             1.00                                                                              71.69            1DLC 858                    ATOM  735                                                                               N  VAL 155                                                                               69.768                                                                             60.470                                                                             38.477                                                                             1.00                                                                              73.01            1DLC 859                    ATOM  736                                                                               CA VAL 155                                                                               69.491                                                                             61.818                                                                             38.977                                                                             1.00                                                                              73.15            1DLC 860                    ATOM  737                                                                               C  VAL 155                                                                               70.486                                                                             62.875                                                                             38.445                                                                             1.00                                                                              75.28            1DLC 861                    ATOM  738                                                                               O  VAL 155                                                                               70.723                                                                             63.903                                                                             39.077                                                                             1.00                                                                              75.71            1DLC 862                    ATOM  739                                                                               CB VAL 155                                                                               69.476                                                                             61.835                                                                             40.528                                                                             1.00                                                                              71.19            1DLC 863                    ATOM  740                                                                               CG1                                                                               VAL 155                                                                               68.762                                                                             63.078                                                                             41.040                                                                             1.00                                                                              70.94            1DLC 864                    ATOM  741                                                                               CG2                                                                               VAL 155                                                                               68.801                                                                             60.577                                                                             41.069                                                                             1.00                                                                              69.36            1DLC 865                    ATOM  742                                                                               N  SER 156                                                                               71.065                                                                             62.602                                                                             37.280                                                                             1.00                                                                              77.11            1DLC 866                    ATOM  743                                                                               CA SER 156                                                                               72.021                                                                             63.495                                                                             36.635                                                                             1.00                                                                              78.87            1DLC 867                    ATOM  744                                                                               C  SER 156                                                                               71.400                                                                             64.161                                                                             35.408                                                                             1.00                                                                              79.29            1DLC 868                    ATOM  745                                                                               O  SER 156                                                                               71.396                                                                             65.386                                                                             35.299                                                                             1.00                                                                              82.25            1DLC 869                    ATOM  746                                                                               CB SER 156                                                                               73.261                                                                             62.709                                                                             36.206                                                                             1.00                                                                              80.07            1DLC 870                    ATOM  747                                                                               OG SER 156                                                                               72.912                                                                             61.680                                                                             35.287                                                                             1.00                                                                              82.65            1DLC 871                    ATOM  748                                                                               N  SER 157                                                                               70.853                                                                             63.352                                                                             34.500                                                                             1.00                                                                              76.97            1DLC 872                    ATOM  749                                                                               CA SER 157                                                                               70.225                                                                             63.867                                                                             33.274                                                                             1.00                                                                              75.30            1DLC 873                    ATOM  750                                                                               C  SER 157                                                                               68.956                                                                             64.689                                                                             33.534                                                                             1.00                                                                              72.28            1DLC 874                    ATOM  751                                                                               O  SER 157                                                                               68.296                                                                             65.162                                                                             32.599                                                                             1.00                                                                              72.55            1DLC 875                    ATOM  752                                                                               CB SER 157                                                                               69.896                                                                             62.715                                                                             32.317                                                                             1.00                                                                              78.07            1DLC 876                    ATOM  753                                                                               OG SER 157                                                                               69.458                                                                             63.189                                                                             31.047                                                                             1.00                                                                              80.58            1DLC 877                    ATOM  754                                                                               N  ARG 158                                                                               68.597                                                                             64.824                                                                             34.805                                                                             1.00                                                                              67.95            1DLC 878                    ATOM  755                                                                               CA ARG 158                                                                               67.422                                                                             65.585                                                                             35.193                                                                             1.00                                                                              62.74            1DLC 879                    ATOM  756                                                                               C  ARG 158                                                                               67.736                                                                             67.076                                                                             35.191                                                                             1.00                                                                              59.17            1DLC 880                    ATOM  757                                                                               O  ARG 158                                                                               68.229                                                                             67.636                                                                             36.170                                                                             1.00                                                                              60.26            1DLC 881                    ATOM  758                                                                               CB ARG 158                                                                               66.933                                                                             65.122                                                                             36.561                                                                             1.00                                                                              62.84            1DLC 882                    ATOM  759                                                                               CG ARG 158                                                                               66.524                                                                             63.677                                                                             36.539                                                                             1.00                                                                              64.01            1DLC 883                    ATOM  760                                                                               CD ARG 158                                                                               66.356                                                                             63.122                                                                             37.919                                                                             1.00                                                                              64.75            1DLC 884                    ATOM  761                                                                               NE ARG 158                                                                               66.051                                                                             61.699                                                                             37.848                                                                             1.00                                                                              67.56            1DLC 885                    ATOM  762                                                                               CZ ARG 158                                                                               65.638                                                                             60.970                                                                             38.879                                                                             1.00                                                                              71.03            1DLC 886                    ATOM  763                                                                               NH1                                                                               ARG 158                                                                               65.479                                                                             61.529                                                                             40.079                                                                             1.00                                                                              70.73            1DLC 887                    ATOM  764                                                                               NH2                                                                               ARG 158                                                                               65.372                                                                             59.678                                                                             38.706                                                                             1.00                                                                              73.39            1DLC 888                    ATOM  765                                                                               N  ASN 159                                                                               67.500                                                                             67.692                                                                             34.045                                                                             1.00                                                                              52.90            1DLC 889                    ATOM  766                                                                               CA ASN 159                                                                               67.737                                                                             69.110                                                                             33.868                                                                             1.00                                                                              46.95            1DLC 890                    ATOM  767                                                                               C  ASN 159                                                                               66.389                                                                             69.826                                                                             33.888                                                                             1.00                                                                              44.55            1DLC 891                    ATOM  768                                                                               O  ASN 159                                                                               65.351                                                                             69.202                                                                             33.666                                                                             1.00                                                                              45.26            1DLC 892                    ATOM  769                                                                               CB ASN 159                                                                               68.435                                                                             69.331                                                                             32.532                                                                             1.00                                                                              45.92            1DLC 893                    ATOM  770                                                                               CG ASN 159                                                                               67.630                                                                             68.811                                                                             31.374                                                                             1.00                                                                              40.97            1DLC 894                    ATOM  771                                                                               OD1                                                                               ASN 159                                                                               66.694                                                                             69.453                                                                             30.928                                                                             1.00                                                                              44.27            1DLC 895                    ATOM  772                                                                               ND2                                                                               ASN 159                                                                               67.971                                                                             67.632                                                                             30.898                                                                             1.00                                                                              42.45            1DLC 896                    ATOM  773                                                                               N  PRO 160                                                                               66.383                                                                             71.148                                                                             34.126                                                                             1.00                                                                              43.08            1DLC 897                    ATOM  774                                                                               CA PRO 160                                                                               65.129                                                                             71.908                                                                             34.161                                                                             1.00                                                                              40.97            1DLC 898                    ATOM  775                                                                               C  PRO 160                                                                               64.253                                                                             71.635                                                                             32.942                                                                             1.00                                                                              40.72            1DLC 899                    ATOM  776                                                                               O  PRO 160                                                                               63.033                                                                             71.541                                                                             33.039                                                                             1.00                                                                              43.29            1DLC 900                    ATOM  777                                                                               CB PRO 160                                                                               65.617                                                                             73.359                                                                             34.167                                                                             1.00                                                                              37.69            1DLC 901                    ATOM  778                                                                               CG PRO 160                                                                               66.883                                                                             73.275                                                                             34.935                                                                             1.00                                                                              38.08            1DLC 902                    ATOM  779                                                                               CD PRO 160                                                                               67.537                                                                             72.036                                                                             34.363                                                                             1.00                                                                              41.86            1DLC 903                    ATOM  780                                                                               N  HIS 161                                                                               64.898                                                                             71.454                                                                             31.800                                                                             1.00                                                                              41.25            1DLC 904                    ATOM  781                                                                               CA HIS 161                                                                               64.199                                                                             71.210                                                                             30.551                                                                             1.00                                                                              41.19            1DLC 905                    ATOM  782                                                                               C  HIS 161                                                                               63.404                                                                             69.905                                                                             30.481                                                                             1.00                                                                              38.76            1DLC 906                    ATOM  783                                                                               O  HIS 161                                                                               62.324                                                                             69.880                                                                             29.901                                                                             1.00                                                                              40.73            1DLC 907                    ATOM  784                                                                               CB HIS 161                                                                               65.191                                                                             71.365                                                                             29.393                                                                             1.00                                                                              46.06            1DLC 908                    ATOM  785                                                                               CG HIS 161                                                                               64.907                                                                             70.490                                                                             28.220                                                                             1.00                                                                              51.42            1DLC 909                    ATOM  786                                                                               ND1                                                                               HIS 161                                                                               63.840                                                                             70.697                                                                             27.371                                                                             1.00                                                                              53.89            1DLC 910                    ATOM  787                                                                               CD2                                                                               HIS 161                                                                               65.564                                                                             69.405                                                                             27.749                                                                             1.00                                                                              54.97            1DLC 911                    ATOM  788                                                                               CE1                                                                               HIS 161                                                                               63.851                                                                             69.775                                                                             26.428                                                                             1.00                                                                              57.18            1DLC 912                    ATOM  789                                                                               NE2                                                                               HIS 161                                                                               64.887                                                                             68.979                                                                             26.633                                                                             1.00                                                                              60.77            1DLC 913                    ATOM  790                                                                               N  SER 162                                                                               63.927                                                                             68.824                                                                             31.048                                                                             1.00                                                                              37.14            1DLC 914                    ATOM  791                                                                               CA SER 162                                                                               63.201                                                                             67.547                                                                             31.031                                                                             1.00                                                                              37.50            1DLC 915                    ATOM  792                                                                               C  SER 162                                                                               62.112                                                                             67.523                                                                             32.108                                                                             1.00                                                                              35.54            1DLC 916                    ATOM  793                                                                               O  SER 162                                                                               61.074                                                                             66.881                                                                             31.944                                                                             1.00                                                                              35.11            1DLC 917                    ATOM  794                                                                               CB SER 162                                                                               64.147                                                                             66.347                                                                             31.188                                                                             1.00                                                                              35.89            1DLC 918                    ATOM  795                                                                               CG SER 162                                                                               64.975                                                                             66.468                                                                             32.332                                                                             1.00                                                                              43.72            1DLC 919                    ATOM  796                                                                               N  GLN 163                                                                               62.349                                                                             68.245                                                                             33.197                                                                             1.00                                                                              33.11            1DLC 920                    ATOM  797                                                                               CA GLN 163                                                                               61.382                                                                             68.351                                                                             34.283                                                                             1.00                                                                              34.19            1DLC 921                    ATOM  798                                                                               C  GLN 163                                                                               60.081                                                                             68.977                                                                             33.769                                                                             1.00                                                                              34.41            1DLC 922                    ATOM  799                                                                               O  GLN 163                                                                               58.986                                                                             68.508                                                                             34.072                                                                             1.00                                                                              35.10            1DLC 923                    ATOM  800                                                                               CB GLN 163                                                                               61.924                                                                             69.248                                                                             35.385                                                                             1.00                                                                              31.93            1DLC 924                    ATOM  801                                                                               CG GLN 163                                                                               63.188                                                                             68.789                                                                             36.034                                                                             1.00                                                                              31.11            1DLC 925                    ATOM  802                                                                               CD GLN 163                                                                               63.564                                                                             69.707                                                                             37.178                                                                             1.00                                                                              37.44            1DLC 926                    ATOM  803                                                                               OE1                                                                               GLN 163                                                                               63.862                                                                             69.258                                                                             38.281                                                                             1.00                                                                              39.60            1DLC 927                    ATOM  804                                                                               NE2                                                                               GLN 163                                                                               63.508                                                                             71.009                                                                             36.932                                                                             1.00                                                                              39.57            1DLC 928                    ATOM  805                                                                               N  GLY 164                                                                               60.216                                                                             70.052                                                                             33.001                                                                             1.00                                                                              33.81            1DLC 929                    ATOM  806                                                                               CA GLY 164                                                                               59.058                                                                             70.733                                                                             32.446                                                                             1.00                                                                              35.60            1DLC 930                    ATOM  807                                                                               C  GLY 164                                                                               58.297                                                                             69.918                                                                             31.416                                                                             1.00                                                                              35.04            1DLC 931                    ATOM  808                                                                               O  GLY 164                                                                               57.116                                                                             70.156                                                                             31.188                                                                             1.00                                                                              36.07            1DLC 932                    ATOM  809                                                                               N  ARG 165                                                                               58.985                                                                             68.971                                                                             30.785                                                                             1.00                                                                              36.94            1DLC 933                    ATOM  810                                                                               CA ARG 165                                                                               58.392                                                                             68.094                                                                             29.774                                                                             1.00                                                                              38.83            1DLC 934                    ATOM  811                                                                               C  ARG 165                                                                               57.436                                                                             67.133                                                                             30.467                                                                             1.00                                                                              38.42            1DLC 935                    ATOM  812                                                                               O  ARG 165                                                                               56.289                                                                             66.960                                                                             30.043                                                                             1.00                                                                              41.35            1DLC 936                    ATOM  813                                                                               CB ARG 165                                                                               59.496                                                                             67.291                                                                             29.061                                                                             1.00                                                                              43.60            1DLC 937                    ATOM  814                                                                               CG ARG 165                                                                               59.010                                                                             66.120                                                                             28.187                                                                             1.00                                                                              49.27            1DLC 938                    ATOM  815                                                                               CD ARG 165                                                                               60.160                                                                             65.155                                                                             27.855                                                                             1.00                                                                              55.07            1DLC 939                    ATOM  816                                                                               NE ARG 165                                                                               59.759                                                                             64.046                                                                             26.979                                                                             1.00                                                                              59.97            1DLC 940                    ATOM  817                                                                               CZ ARG 165                                                                               60.243                                                                             62.804                                                                             27.059                                                                             1.00                                                                              64.96            1DLC 941                    ATOM  818                                                                               NH1                                                                               ARG 165                                                                               61.153                                                                             62.491                                                                             27.981                                                                             1.00                                                                              64.66            1DLC 942                    ATOM  819                                                                               NH2                                                                               ARG 165                                                                               59.843                                                                             61.869                                                                             26.199                                                                             1.00                                                                              64.23            1DLC 943                    ATOM  820                                                                               N  ILE 166                                                                               57.915                                                                             66.523                                                                             31.548                                                                             1.00                                                                              35.09            1DLC 944                    ATOM  821                                                                               CA ILE 166                                                                               57.118                                                                             65.572                                                                             32.310                                                                             1.00                                                                              33.64            1DLC 945                    ATOM  822                                                                               C  ILE 166                                                                               55.992                                                                             66.289                                                                             33.081                                                                             1.00                                                                              33.53            1DLC 946                    ATOM  823                                                                               O  ILE 166                                                                               54.861                                                                             65.806                                                                             33.128                                                                             1.00                                                                              31.99            1DLC 947                    ATOM  824                                                                               CB ILE 166                                                                               58.024                                                                             64.698                                                                             33.236                                                                             1.00                                                                              30.93            1DLC 948                    ATOM  825                                                                               CG1                                                                               ILE 166                                                                               57.315                                                                             63.392                                                                             33.595                                                                             1.00                                                                              30.98            1DLC 949                    ATOM  826                                                                               CG2                                                                               ILE 166                                                                               58.432                                                                             65.459                                                                             34.481                                                                             1.00                                                                              24.94            1DLC 950                    ATOM  827                                                                               CD1                                                                               ILE 166                                                                               58.200                                                                             62.399                                                                             34.321                                                                             1.00                                                                              34.42            1DLC 951                    ATOM  828                                                                               N  ARG 167                                                                               56.292                                                                             67.473                                                                             33.611                                                                             1.00                                                                              34.45            1DLC 952                    ATOM  829                                                                               CA ARG 167                                                                               55.308                                                                             68.267                                                                             34.342                                                                             1.00                                                                              32.89            1DLC 953                    ATOM  830                                                                               C  ARG 167                                                                               54.109                                                                             68.617                                                                             33.476                                                                             1.00                                                                              34.17            1DLC 954                    ATOM  831                                                                               O  ARG 167                                                                               52.969                                                                             68.487                                                                             33.917                                                                             1.00                                                                              35.50            1DLC 955                    ATOM  832                                                                               CB ARG 167                                                                               55.918                                                                             69.559                                                                             34.891                                                                             1.00                                                                              31.58            1DLC 956                    ATOM  833                                                                               CG ARG 167                                                                               56.805                                                                             69.377                                                                             36.112                                                                             1.00                                                                              32.53            1DLC 957                    ATOM  834                                                                               CD ARG 167                                                                               56.993                                                                             70.697                                                                             36.848                                                                             1.00                                                                              33.11            1DLC 958                    ATOM  835                                                                               NE ARG 167                                                                               57.385                                                                             71.778                                                                             35.944                                                                             1.00                                                                              37.56            1DLC 959                    ATOM  836                                                                               CZ ARG 167                                                                               58.639                                                                             72.165                                                                             35.720                                                                             1.00                                                                              35.70            1DLC 960                    ATOM  837                                                                               NH1                                                                               ARG 167                                                                               59.647                                                                             71.567                                                                             36.335                                                                             1.00                                                                              35.92            1DLC 961                    ATOM  838                                                                               NH2                                                                               ARG 167                                                                               58.883                                                                             73.154                                                                             34.873                                                                             1.00                                                                              36.61            1DLC 962                    ATOM  839                                                                               N  GLU 168                                                                               54.346                                                                             69.050                                                                             32.242                                                                             1.00                                                                              34.64            1DLC 963                    ATOM  840                                                                               CA GLU 168                                                                               53.213                                                                             69.388                                                                             31.390                                                                             1.00                                                                              38.41            1DLC 964                    ATOM  841                                                                               C  GLU 168                                                                               52.484                                                                             68.185                                                                             30.790                                                                             1.00                                                                              37.42            1DLC 965                    ATOM  842                                                                               O  GLU 168                                                                               51.286                                                                             68.266                                                                             30.497                                                                             1.00                                                                              37.11            1DLC 966                    ATOM  843                                                                               CB GLU 168                                                                               53.550                                                                             70.461                                                                             30.348                                                                             1.00                                                                              41.15            1DLC 967                    ATOM  844                                                                               CG GLU 168                                                                               54.653                                                                             70.159                                                                             29.376                                                                             1.00                                                                              47.25            1DLC 968                    ATOM  845                                                                               CD GLU 168                                                                               55.073                                                                             71.413                                                                             28.623                                                                             1.00                                                                              50.54            1DLC 969                    ATOM  846                                                                               OE1                                                                               GLU 168                                                                               55.649                                                                             72.322                                                                             29.266                                                                             1.00                                                                              51.72            1DLC 970                    ATOM  847                                                                               OE2                                                                               GLU 168                                                                               54.808                                                                             71.504                                                                             27.402                                                                             1.00                                                                              49.76            1DLC 971                    ATOM  848                                                                               N  LEU 169                                                                               53.187                                                                             67.065                                                                             30.639                                                                             1.00                                                                              35.43            1DLC 972                    ATOM  849                                                                               CA LEU 169                                                                               52.553                                                                             65.849                                                                             30.137                                                                             1.00                                                                              33.88            1DLC 973                    ATOM  850                                                                               C  LEU 169                                                                               51.561                                                                             65.385                                                                             31.216                                                                             1.00                                                                              35.40            1DLC 974                    ATOM  851                                                                               O  LEU 169                                                                               50.422                                                                             64.987                                                                             30.921                                                                             1.00                                                                              33.65            1DLC 975                    ATOM  852                                                                               CB LEU 169                                                                               53.593                                                                             64.752                                                                             29.876                                                                             1.00                                                                              34.42            1DLC 976                    ATOM  853                                                                               CG LEU 169                                                                               54.409                                                                             64.833                                                                             28.582                                                                             1.00                                                                              32.40            1DLC 977                    ATOM  854                                                                               CD1                                                                               LEU 169                                                                               55.219                                                                             63.568                                                                             28.399                                                                             1.00                                                                              29.86            1DLC 978                    ATOM  855                                                                               CD2                                                                               LEU 169                                                                               53.477                                                                             65.002                                                                             27.412                                                                             1.00                                                                              30.50            1DLC 979                    ATOM  856                                                                               N  PHE 170                                                                               52.003                                                                             65.476                                                                             32.470                                                                             1.00                                                                              34.05            1DLC 980                    ATOM  857                                                                               CA PHE 170                                                                               51.193                                                                             65.107                                                                             33.625                                                                             1.00                                                                              31.26            1DLC 981                    ATOM  858                                                                               C  PHE 170                                                                               49.989                                                                             66.045                                                                             33.765                                                                             1.00                                                                              31.02            1DLC 982                    ATOM  859                                                                               O  PHE 170                                                                               48.861                                                                             65.584                                                                             33.885                                                                             1.00                                                                              32.68            1DLC 983                    ATOM  860                                                                               CB PHE 170                                                                               52.038                                                                             65.150                                                                             34.901                                                                             1.00                                                                              28.00            1DLC 984                    ATOM  861                                                                               CG PHE 170                                                                               51.288                                                                             64.746                                                                             36.135                                                                             1.00                                                                              27.48            1DLC 985                    ATOM  862                                                                               CD1                                                                               PHE 170                                                                               51.194                                                                             63.407                                                                             36.499                                                                             1.00                                                                              26.84            1DLC 986                    ATOM  863                                                                               CD2                                                                               PHE 170                                                                               50.657                                                                             65.698                                                                             36.923                                                                             1.00                                                                              24.94            1DLC 987                    ATOM  864                                                                               CE1                                                                               PHE 170                                                                               50.479                                                                             63.021                                                                             37.630                                                                             1.00                                                                              24.21            1DLC 988                    ATOM  865                                                                               CE2                                                                               PHE 170                                                                               49.941                                                                             65.320                                                                             38.052                                                                             1.00                                                                              26.51            1DLC 989                    ATOM  866                                                                               CZ PHE 170                                                                               49.852                                                                             63.977                                                                             38.405                                                                             1.00                                                                              24.66            1DLC 990                    ATOM  867                                                                               N  SER 171                                                                               50.231                                                                             67.356                                                                             33.759                                                                             1.00                                                                              31.26            1DLC 991                    ATOM  868                                                                               CA SER 171                                                                               49.147                                                                             68.335                                                                             33.867                                                                             1.00                                                                              30.81            1DLC 992                    ATOM  869                                                                               C  SER 171                                                                               48.107                                                                             68.152                                                                             32.770                                                                             1.00                                                                              32.20            1DLC 993                    ATOM  870                                                                               O  SER 171                                                                               46.915                                                                             68.359                                                                             32.996                                                                             1.00                                                                              32.31            1DLC 994                    ATOM  871                                                                               CB SER 171                                                                               49.681                                                                             69.766                                                                             33.821                                                                             1.00                                                                              30.26            1DLC 995                    ATOM  872                                                                               OG SER 171                                                                               50.166                                                                             70.179                                                                             35.089                                                                             1.00                                                                              36.66            1DLC 996                    ATOM  873                                                                               N  GLN 172                                                                               48.563                                                                             67.781                                                                             31.577                                                                             1.00                                                                              31.91            1DLC 997                    ATOM  874                                                                               CA GLN 172                                                                               47.659                                                                             67.552                                                                             30.455                                                                             1.00                                                                              33.14            1DLC 998                    ATOM  875                                                                               C  GLN 172                                                                               46.733                                                                             66.365                                                                             30.710                                                                             1.00                                                                              29.58            1DLC 999                    ATOM  876                                                                               O  GLN 172                                                                               45.516                                                                             66.488                                                                             30.614                                                                             1.00                                                                              30.17            1DLC1000                    ATOM  877                                                                               CB GLN 172                                                                               48.445                                                                             67.330                                                                             29.155                                                                             1.00                                                                              37.12            1DLC1001                    ATOM  878                                                                               CG GLN 172                                                                               48.917                                                                             68.614                                                                             28.486                                                                             1.00                                                                              45.43            1DLC1002                    ATOM  879                                                                               CD GLN 172                                                                               47.759                                                                             69.492                                                                             28.022                                                                             1.00                                                                              49.43            1DLC1003                    ATOM  880                                                                               OE1                                                                               GLN 172                                                                               46.967                                                                             69.099                                                                             27.163                                                                             1.00                                                                              52.00            1DLC1004                    ATOM  881                                                                               NE2                                                                               GLN 172                                                                               47.660                                                                             70.688                                                                             28.586                                                                             1.00                                                                              49.43            1DLC1005                    ATOM  882                                                                               N  ALA 173                                                                               47.313                                                                             65.223                                                                             31.057                                                                             1.00                                                                              24.78            1DLC1006                    ATOM  883                                                                               CA ALA 173                                                                               46.533                                                                             64.027                                                                             31.321                                                                             1.00                                                                              22.98            1DLC1007                    ATOM  884                                                                               C  ALA 173                                                                               45.524                                                                             64.270                                                                             32.442                                                                             1.00                                                                              24.72            1DLC1008                    ATOM  885                                                                               O  ALA 173                                                                               44.319                                                                             64.077                                                                             32.254                                                                             1.00                                                                              28.98            1DLC1009                    ATOM  886                                                                               CB ALA 173                                                                               47.448                                                                             62.864                                                                             31.662                                                                             1.00                                                                              17.04            1DLC1010                    ATOM  887                                                                               N  GLU 174                                                                               46.007                                                                             64.756                                                                             33.583                                                                             1.00                                                                              22.65            1DLC1011                    ATOM  888                                                                               CA GLU 174                                                                               45.153                                                                             65.032                                                                             34.739                                                                             1.00                                                                              22.62            1DLC1012                    ATOM  889                                                                               C  GLU 174                                                                               43.983                                                                             65.962                                                                             34.379                                                                             1.00                                                                              23.92            1DLC1013                    ATOM  890                                                                               O  GLU 174                                                                               42.821                                                                             65.690                                                                             34.703                                                                             1.00                                                                              24.12            1DLC1014                    ATOM  891                                                                               CB GLU 174                                                                               45.993                                                                             65.646                                                                             35.862                                                                             1.00                                                                              20.71            1DLC1015                    ATOM  892                                                                               CG GLU 174                                                                               45.347                                                                             65.635                                                                             37.245                                                                             1.00                                                                              27.17            1DLC1016                    ATOM  893                                                                               CD GLU 174                                                                               44.233                                                                             66.665                                                                             37.422                                                                             1.00                                                                              26.70            1DLC1017                    ATOM  894                                                                               OE1                                                                               GLU 174                                                                               44.464                                                                             67.856                                                                             37.132                                                                             1.00                                                                              30.91            1DLC1018                    ATOM  895                                                                               OE2                                                                               GLU 174                                                                               43.129                                                                             66.287                                                                             37.864                                                                             1.00                                                                              25.52            1DLC1019                    ATOM  896                                                                               N  SER 175                                                                               44.301                                                                             67.045                                                                             33.684                                                                             1.00                                                                              25.54            1DLC1020                    ATOM  897                                                                               CA SER 175                                                                               43.308                                                                             68.022                                                                             33.262                                                                             1.00                                                                              25.56            1DLC1021                    ATOM  898                                                                               C  SER 175                                                                               42.301                                                                             67.409                                                                             32.283                                                                             1.00                                                                              27.17            1DLC1022                    ATOM  899                                                                               O  SER 175                                                                               41.097                                                                             67.641                                                                             32.389                                                                             1.00                                                                              27.41            1DLC1023                    ATOM  900                                                                               CB SER 175                                                                               44.006                                                                             69.214                                                                             32.611                                                                             1.00                                                                              23.74            1DLC1024                    ATOM  901                                                                               OG SER 175                                                                               43.135                                                                             70.322                                                                             32.527                                                                             1.00                                                                              33.11            1DLC1025                    ATOM  902                                                                               N  HIS 176                                                                               42.794                                                                             66.593                                                                             31.354                                                                             1.00                                                                              29.90            1DLC1026                    ATOM  903                                                                               CA HIS 176                                                                               41.941                                                                             65.937                                                                             30.364                                                                             1.00                                                                              30.36            1DLC1027                    ATOM  904                                                                               C  HIS 176                                                                               40.948                                                                             65.023                                                                             31.080                                                                             1.00                                                                              28.97            1DLC1028                    ATOM  905                                                                               O  HIS 176                                                                               39.793                                                                             64.905                                                                             30.675                                                                             1.00                                                                              29.85            1DLC1029                    ATOM  906                                                                               CB HIS 176                                                                               42.795                                                                             65.139                                                                             29.367                                                                             1.00                                                                              34.90            1DLC1030                    ATOM  907                                                                               CG HIS 176                                                                               42.059                                                                             64.703                                                                             28.131                                                                             1.00                                                                              46.08            1DLC1031                    ATOM  908                                                                               ND1                                                                               HIS 176                                                                               40.692                                                                             64.506                                                                             28.094                                                                             1.00                                                                              49.82            1DLC1032                    ATOM  909                                                                               CD2                                                                               HIS 176                                                                               42.510                                                                             64.405                                                                             26.888                                                                             1.00                                                                              48.94            1DLC1033                    ATOM  910                                                                               CE1                                                                               HIS 176                                                                               40.335                                                                             64.107                                                                             26.886                                                                             1.00                                                                              50.00            1DLC1034                    ATOM  911                                                                               NE2                                                                               HIS 176                                                                               41.421                                                                             64.036                                                                             26.135                                                                             1.00                                                                              50.95            1DLC1035                    ATOM  912                                                                               N  PHE 177                                                                               41.386                                                                             64.401                                                                             32.165                                                                             1.00                                                                              26.81            1DLC1036                    ATOM  913                                                                               CA PHE 177                                                                               40.501                                                                             63.525                                                                             32.916                                                                             1.00                                                                              27.11            1DLC1037                    ATOM  914                                                                               C  PHE 177                                                                               39.326                                                                             64.261                                                                             33.562                                                                             1.00                                                                              25.34            1DLC1038                    ATOM  915                                                                               O  PHE 177                                                                               38.188                                                                             63.814                                                                             33.482                                                                             1.00                                                                              26.87            1DLC1039                    ATOM  916                                                                               CB PHE 177                                                                               41.285                                                                             62.731                                                                             33.961                                                                             1.00                                                                              27.16            1DLC1040                    ATOM  917                                                                               CG PHE 177                                                                               41.851                                                                             61.443                                                                             33.439                                                                             1.00                                                                              27.15            1DLC1041                    ATOM  918                                                                               CD1                                                                               PHE 177                                                                               41.033                                                                             60.321                                                                             33.292                                                                             1.00                                                                              26.85            1DLC1042                    ATOM  919                                                                               CD2                                                                               PHE 177                                                                               43.188                                                                             61.352                                                                             33.074                                                                             1.00                                                                              24.38            1DLC1043                    ATOM  920                                                                               CE1                                                                               PHE 177                                                                               41.544                                                                             59.127                                                                             32.787                                                                             1.00                                                                              26.71            1DLC1044                    ATOM  921                                                                               CE2                                                                               PHE 177                                                                               43.706                                                                             60.172                                                                             32.571                                                                             1.00                                                                              26.25            1DLC1045                    ATOM  922                                                                               CZ PHE 177                                                                               42.882                                                                             59.055                                                                             32.426                                                                             1.00                                                                              27.48            1DLC1046                    ATOM  923                                                                               N  ARG 178                                                                               39.595                                                                             65.400                                                                             34.183                                                                             1.00                                                                              24.09            1DLC1047                    ATOM  924                                                                               CA ARG 178                                                                               38.534                                                                             66.168                                                                             34.821                                                                             1.00                                                                              21.85            1DLC1048                    ATOM  925                                                                               C  ARG 178                                                                               37.544                                                                             66.715                                                                             33.796                                                                             1.00                                                                              25.36            1DLC1049                    ATOM  926                                                                               O  ARG 178                                                                               36.344                                                                             66.828                                                                             34.949                                                                             1.00                                                                              28.72            1DLC1050                    ATOM  927                                                                               CB ARG 178                                                                               39.128                                                                             67.309                                                                             35.637                                                                             1.00                                                                              18.36            1DLC1051                    ATOM  928                                                                               CG ARG 178                                                                               39.744                                                                             66.866                                                                             36.940                                                                             1.00                                                                              19.50            1DLC1052                    ATOM  929                                                                               CD ARG 178                                                                               40.263                                                                             68.050                                                                             37.730                                                                             1.00                                                                              18.54            1DLC1053                    ATOM  930                                                                               NE ARG 178                                                                               41.446                                                                             68.641                                                                             37.119                                                                             1.00                                                                              19.88            1DLC1054                    ATOM  931                                                                               CZ ARG 178                                                                               41.544                                                                             69.911                                                                             36.742                                                                             1.00                                                                              23.68            1DLC1055                    ATOM  932                                                                               NH1                                                                               ARG 178                                                                               40.522                                                                             70.739                                                                             36.906                                                                             1.00                                                                              25.01            1DLC1056                    ATOM  933                                                                               NH2                                                                               ARG 178                                                                               42.669                                                                             70.356                                                                             36.202                                                                             1.00                                                                              22.04            1DLC1057                    ATOM  934                                                                               N  ASN 179                                                                               38.056                                                                             67.009                                                                             32.614                                                                             1.00                                                                              26.63            1DLC1058                    ATOM  935                                                                               CA ASN 179                                                                               37.241                                                                             67.544                                                                             31.548                                                                             1.00                                                                              30.38            1DLC1059                    ATOM  936                                                                               C  ASN 179                                                                               36.323                                                                             66.476                                                                             30.938                                                                             1.00                                                                              32.76            1DLC1060                    ATOM  937                                                                               O  ASN 179                                                                               35.156                                                                             66.742                                                                             30.636                                                                             1.00                                                                              33.01            1DLC1061                    ATOM  938                                                                               CB ASN 179                                                                               38.163                                                                             68.128                                                                             30.487                                                                             1.00                                                                              38.68            1DLC1062                    ATOM  939                                                                               CG ASN 179                                                                               37.478                                                                             69.159                                                                             29.638                                                                             1.00                                                                              50.42            1DLC1063                    ATOM  940                                                                               OD1                                                                               ASN 179                                                                               37.101                                                                             68.889                                                                             28.496                                                                             1.00                                                                              58.00            1DLC1064                    ATOM  941                                                                               ND2                                                                               ASN 179                                                                               37.295                                                                             70.353                                                                             30.191                                                                             1.00                                                                              56.89            1DLC1065                    ATOM  942                                                                               N  SER 180                                                                               36.849                                                                             65.257                                                                             30.815                                                                             1.00                                                                              31.80            1DLC1066                    ATOM  943                                                                               CA SER 180                                                                               36.123                                                                             64.128                                                                             30.229                                                                             1.00                                                                              29.25            1DLC1067                    ATOM  944                                                                               C  SER 180                                                                               35.138                                                                             63.345                                                                             31.101                                                                             1.00                                                                              28.52            1DLC1068                    ATOM  945                                                                               O  SER 180                                                                               34.139                                                                             62.844                                                                             30.592                                                                             1.00                                                                              29.31            1DLC1069                    ATOM  946                                                                               CB SER 180                                                                               37.108                                                                             63.140                                                                             29.606                                                                             1.00                                                                              26.37            1DLC1070                    ATOM  947                                                                               OG SER 180                                                                               37.889                                                                             63.786                                                                             28.624                                                                             1.00                                                                              28.28            1DLC1071                    ATOM  948                                                                               N  MET 181                                                                               35.411                                                                             63.222                                                                             32.397                                                                             1.00                                                                              25.80            1DLC1072                    ATOM  949                                                                               CA MET 181                                                                               34.535                                                                             62.467                                                                             33.295                                                                             1.00                                                                              24.36            1DLC1073                    ATOM  950                                                                               C  MET 181                                                                               33.013                                                                             62.660                                                                             33.109                                                                             1.00                                                                              25.40            1DLC1074                    ATOM  951                                                                               O  MET 181                                                                               32.260                                                                             61.678                                                                             33.070                                                                             1.00                                                                              25.51            1DLC1075                    ATOM  952                                                                               CB MET 181                                                                               34.939                                                                             62.674                                                                             34.760                                                                             1.00                                                                              19.33            1DLC1076                    ATOM  953                                                                               CG MET 181                                                                               36.253                                                                             61.994                                                                             35.152                                                                             1.00                                                                              20.86            1DLC1077                    ATOM  954                                                                               SD MET 181                                                                               36.411                                                                             60.263                                                                             34.634                                                                             1.00                                                                              21.66            1DLC1078                    ATOM  955                                                                               CE MET 181                                                                               35.276                                                                             59.487                                                                             35.735                                                                             1.00                                                                              16.01            1DLC1079                    ATOM  956                                                                               N  PRO 182                                                                               32.545                                                                             63.913                                                                             32.954                                                                             1.00                                                                              25.51            1DLC1080                    ATOM  957                                                                               CA PRO 182                                                                               31.103                                                                             64.138                                                                             32.772                                                                             1.00                                                                              25.99            1DLC1081                    ATOM  958                                                                               C  PRO 182                                                                               30.491                                                                             63.331                                                                             31.615                                                                             1.00                                                                              25.29            1DLC1082                    ATOM  959                                                                               O  PRO 182                                                                               29.311                                                                             63.003                                                                             31.640                                                                             1.00                                                                              27.08            1DLC1083                    ATOM  960                                                                               CB PRO 182                                                                               31.031                                                                             65.640                                                                             32.507                                                                             1.00                                                                              25.60            1DLC1084                    ATOM  961                                                                               CG PRO 182                                                                               32.160                                                                             66.174                                                                             33.318                                                                             1.00                                                                              23.18            1DLC1085                    ATOM  962                                                                               CD PRO 182                                                                               33.264                                                                             65.200                                                                             33.017                                                                             1.00                                                                              25.77            1DLC1086                    ATOM  963                                                                               N  SER 183                                                                               31.303                                                                             63.000                                                                             30.617                                                                             1.00                                                                              24.96            1DLC1087                    ATOM  964                                                                               CA SER 183                                                                               30.842                                                                             62.226                                                                             29.465                                                                             1.00                                                                              26.52            1DLC1088                    ATOM  965                                                                               C  SER 183                                                                               30.491                                                                             60.792                                                                             29.817                                                                             1.00                                                                              26.32            1DLC1089                    ATOM  966                                                                               O  SER 183                                                                               29.785                                                                             60.122                                                                             29.068                                                                             1.00                                                                              29.73            1DLC1090                    ATOM  967                                                                               CB SER 183                                                                               31.899                                                                             62.204                                                                             28.356                                                                             1.00                                                                              25.87            1DLC1091                    ATOM  968                                                                               OG SER 183                                                                               31.952                                                                             63.438                                                                             27.666                                                                             1.00                                                                              34.94            1DLC1092                    ATOM  969                                                                               N  PHE 184                                                                               31.025                                                                             60.300                                                                             30.928                                                                             1.00                                                                              26.09            1DLC1093                    ATOM  970                                                                               CA PHE 184                                                                               30.754                                                                             58.928                                                                             31.357                                                                             1.00                                                                              25.51            1DLC1094                    ATOM  971                                                                               C  PHE 184                                                                               29.683                                                                             58.923                                                                             32.447                                                                             1.00                                                                              24.26            1DLC1095                    ATOM  972                                                                               O  PHE 184                                                                               29.529                                                                             57.957                                                                             33.188                                                                             1.00                                                                              24.61            1DLC1096                    ATOM  973                                                                               CB PHE 184                                                                               32.039                                                                             58.266                                                                             31.859                                                                             1.00                                                                              23.91            1DLC1097                    ATOM  974                                                                               CG PHE 184                                                                               33.248                                                                             58.594                                                                             31.031                                                                             1.00                                                                              25.50            1DLC1098                    ATOM  975                                                                               CD1                                                                               PHE 184                                                                               33.228                                                                             58.437                                                                             29.648                                                                             1.00                                                                              25.62            1DLC1099                    ATOM  976                                                                               CD2                                                                               PHE 184                                                                               34.402                                                                             59.085                                                                             31.630                                                                             1.00                                                                              23.80            1DLC1100                    ATOM  977                                                                               CE1                                                                               PHE 184                                                                               34.339                                                                             58.767                                                                             28.876                                                                             1.00                                                                              26.43            1DLC1101                    ATOM  978                                                                               CE2                                                                               PHE 184                                                                               35.515                                                                             59.418                                                                             30.866                                                                             1.00                                                                              24.57            1DLC1102                    ATOM  979                                                                               CZ PHE 184                                                                               35.485                                                                             59.260                                                                             29.488                                                                             1.00                                                                              23.14            1DLC1103                    ATOM  980                                                                               N  ALA 185                                                                               28.925                                                                             60.007                                                                             32.522                                                                             1.00                                                                              23.06            1DLC1104                    ATOM  981                                                                               CA ALA 185                                                                               27.879                                                                             60.119                                                                             33.518                                                                             1.00                                                                              24.13            1DLC1105                    ATOM  982                                                                               C  ALA 185                                                                               26.708                                                                             60.976                                                                             33.041                                                                             1.00                                                                              23.68            1DLC1106                    ATOM  983                                                                               O  ALA 185                                                                               26.076                                                                             61.650                                                                             33.841                                                                             1.00                                                                              27.10            1DLC1107                    ATOM  984                                                                               CB ALA 185                                                                               28.461                                                                             60.681                                                                             34.803                                                                             1.00                                                                              19.53            1DLC1108                    ATOM  985                                                                               N  ILE 186                                                                               26.396                                                                             60.930                                                                             31.749                                                                             1.00                                                                              26.51            1DLC1109                    ATOM  986                                                                               CA ILE 186                                                                               25.287                                                                             61.737                                                                             31.219                                                                             1.00                                                                              30.55            1DLC1110                    ATOM  987                                                                               C  ILE 186                                                                               23.923                                                                             61.273                                                                             31.738                                                                             1.00                                                                              31.15            1DLC1111                    ATOM  988                                                                               O  ILE 186                                                                               23.660                                                                             60.073                                                                             31.881                                                                             1.00                                                                              30.54            1DLC1112                    ATOM  989                                                                               CB ILE 186                                                                               25.310                                                                             61.876                                                                             29.645                                                                             1.00                                                                              32.49            1DLC1113                    ATOM  990                                                                               CG1                                                                               ILE 186                                                                               23.994                                                                             61.413                                                                             29.014                                                                             1.00                                                                              35.37            1DLC1114                    ATOM  991                                                                               CG2                                                                               ILE 186                                                                               26.506                                                                             61.164                                                                             29.036                                                                             1.00                                                                              32.13            1DLC1115                    ATOM  992                                                                               CD1                                                                               ILE 186                                                                               22.958                                                                             62.522                                                                             28.851                                                                             1.00                                                                              41.70            1DLC1116                    ATOM  993                                                                               N  SER 187                                                                               23.061                                                                             62.243                                                                             32.025                                                                             1.00                                                                              34.59            1DLC1117                    ATOM  994                                                                               CA SER 187                                                                               21.730                                                                             61.969                                                                             32.570                                                                             1.00                                                                              35.55            1DLC1118                    ATOM  995                                                                               C  SER 187                                                                               20.948                                                                             60.887                                                                             31.836                                                                             1.00                                                                              32.95            1DLC1119                    ATOM  996                                                                               O  SER 187                                                                               20.761                                                                             60.942                                                                             30.620                                                                             1.00                                                                              33.44            1DLC1120                    ATOM  997                                                                               CB SER 187                                                                               20.905                                                                             63.252                                                                             32.665                                                                             1.00                                                                              35.13            1DLC1121                    ATOM  998                                                                               OG SER 187                                                                               19.848                                                                             63.077                                                                             33.595                                                                             1.00                                                                              42.12            1DLC1122                    ATOM  999                                                                               N  GLY 188                                                                               20.493                                                                             59.899                                                                             32.593                                                                             1.00                                                                              30.43            1DLC1123                    ATOM  1000                                                                              CA GLY 188                                                                               19.761                                                                             58.799                                                                             32.001                                                                             1.00                                                                              28.56            1DLC1124                    ATOM  1001                                                                              C  GLY 188                                                                               20.642                                                                             57.624                                                                             31.609                                                                             1.00                                                                              28.57            1DLC1125                    ATOM  1002                                                                              O  GLY 188                                                                               20.135                                                                             56.536                                                                             31.335                                                                             1.00                                                                              31.17            1DLC1126                    ATOM  1003                                                                              N  TYR 189                                                                               21.957                                                                             57.821                                                                             31.584                                                                             1.00                                                                              27.24            1DLC1127                    ATOM  1004                                                                              CA TYR 189                                                                               22.870                                                                             56.734                                                                             31.222                                                                             1.00                                                                              27.78            1DLC1128                    ATOM  1005                                                                              C  TYR 189                                                                               23.913                                                                             56.391                                                                             32.282                                                                             1.00                                                                              25.94            1DLC1129                    ATOM  1006                                                                              O  TYR 189                                                                               24.832                                                                             55.615                                                                             32.031                                                                             1.00                                                                              27.94            1DLC1130                    ATOM  1007                                                                              CB TYR 189                                                                               23.541                                                                             57.031                                                                             29.883                                                                             1.00                                                                              30.52            1DLC1131                    ATOM  1008                                                                              CG TYR 189                                                                               22.541                                                                             57.088                                                                             28.765                                                                             1.00                                                                              35.63            1DLC1132                    ATOM  1009                                                                              CD1                                                                               TYR 189                                                                               21.957                                                                             55.925                                                                             28.280                                                                             1.00                                                                              37.70            1DLC1133                    ATOM  1010                                                                              CD2                                                                               TYR 189                                                                               22.125                                                                             58.307                                                                             28.237                                                                             1.00                                                                              38.49            1DLC1134                    ATOM  1011                                                                              CE1                                                                               TYR 189                                                                               20.979                                                                             55.967                                                                             27.302                                                                             1.00                                                                              44.20            1DLC1135                    ATOM  1012                                                                              CE2                                                                               TYR 189                                                                               21.146                                                                             58.366                                                                             27.255                                                                             1.00                                                                              43.26            1DLC1136                    ATOM  1013                                                                              CZ TYR 189                                                                               20.573                                                                             57.190                                                                             26.791                                                                             1.00                                                                              47.00            1DLC1137                    ATOM  1014                                                                              OH TYR 189                                                                               19.593                                                                             57.227                                                                             25.816                                                                             1.00                                                                              53.52            1DLC1138                    ATOM  1015                                                                              N  GLU 190                                                                               23.719                                                                             56.921                                                                             33.484                                                                             1.00                                                                              24.53            1DLC1139                    ATOM  1016                                                                              CA GLU 190                                                                               24.624                                                                             56.700                                                                             34.609                                                                             1.00                                                                              23.53            1DLC1140                    ATOM  1017                                                                              C  GLU 190                                                                               24.978                                                                             55.243                                                                             34.900                                                                             1.00                                                                              24.17            1DLC1141                    ATOM  1018                                                                              O  GLU 190                                                                               26.153                                                                             54.912                                                                             35.031                                                                             1.00                                                                              27.99            1DLC1142                    ATOM  1019                                                                              CB GLU 190                                                                               24.068                                                                             57.352                                                                             35.872                                                                             1.00                                                                              24.72            1DLC1143                    ATOM  1020                                                                              CG GLU 190                                                                               23.907                                                                             58.865                                                                             35.776                                                                             1.00                                                                              26.76            1DLC1144                    ATOM  1021                                                                              CD GLU 190                                                                               22.541                                                                             59.318                                                                             35.278                                                                             1.00                                                                              25.80            1DLC1145                    ATOM  1022                                                                              OE1                                                                               GLU 190                                                                               21.778                                                                             58.510                                                                             34.718                                                                             1.00                                                                              26.88            1DLC1146                    ATOM  1023                                                                              OE2                                                                               GLU 190                                                                               22.219                                                                             60.502                                                                             35.471                                                                             1.00                                                                              30.62            1DLC1147                    ATOM  1024                                                                              N  VAL 191                                                                               23.973                                                                             54.375                                                                             34.996                                                                             1.00                                                                              23.30            1DLC1148                    ATOM  1025                                                                              CA VAL 191                                                                               24.207                                                                             52.952                                                                             35.272                                                                             1.00                                                                              19.79            1DLC1149                    ATOM  1026                                                                              C  VAL 191                                                                               24.897                                                                             52.243                                                                             34.108                                                                             1.00                                                                              19.46            1DLC1150                    ATOM  1027                                                                              O  VAL 191                                                                               25.799                                                                             51.432                                                                             34.308                                                                             1.00                                                                              22.56            1DLC1151                    ATOM  1028                                                                              CB VAL 191                                                                               22.889                                                                             52.203                                                                             35.615                                                                             1.00                                                                              18.04            1DLC1152                    ATOM  1029                                                                              CG1                                                                               VAL 191                                                                               23.163                                                                             50.719                                                                             35.865                                                                             1.00                                                                              18.90            1DLC1153                    ATOM  1030                                                                              CG2                                                                               VAL 191                                                                               22.232                                                                             52.824                                                                             36.845                                                                             1.00                                                                              20.32            1DLC1154                    ATOM  1031                                                                              N  LEU 192                                                                               24.491                                                                             52.566                                                                             32.890                                                                             1.00                                                                              18 69            1DLC1155                    ATOM  1032                                                                              CA LEU 192                                                                               25.082                                                                             51.941                                                                             31.717                                                                             1.00                                                                              19.74            1DLC1156                    ATOM  1033                                                                              C  LEU 192                                                                               26.572                                                                             52.295                                                                             31.545                                                                             1.00                                                                              20.71            1DLC1157                    ATOM  1034                                                                              G  LEU 192                                                                               27.359                                                                             51.487                                                                             31.061                                                                             1.00                                                                              21.17            1DLC1158                    ATOM  1035                                                                              CB LEU 192                                                                               24.271                                                                             52.294                                                                             30.464                                                                             1.00                                                                              18.07            1DLC1159                    ATOM  1036                                                                              CG LEU 192                                                                               22.806                                                                             51.827                                                                             30.419                                                                             1.00                                                                              20.22            1DLC1160                    ATOM  1037                                                                              CD1                                                                               LEU 192                                                                               22.152                                                                             52.272                                                                             29.115                                                                             1.00                                                                              18.09            1DLC1161                    ATOM  1038                                                                              CD2                                                                               LEU 192                                                                               22.717                                                                             50.312                                                                             30.547                                                                             1.00                                                                              20.02            1DLC1162                    ATOM  1039                                                                              N  PHE 193                                                                               26.955                                                                             53.496                                                                             31.962                                                                             1.00                                                                              20.56            1DLC1163                    ATOM  1040                                                                              CA PHE 193                                                                               28.348                                                                             53.942                                                                             31.871                                                                             1.00                                                                              20.78            1DLC1164                    ATOM  1041                                                                              C  PHE 193                                                                               29.168                                                                             53.568                                                                             33.104                                                                             1.00                                                                              21.28            1DLC1165                    ATOM  1042                                                                              O  PHE 193                                                                               30.340                                                                             53.907                                                                             33.174                                                                             1.00                                                                              23.88            1DLC1166                    ATOM  1043                                                                              CB PHE 193                                                                               28.408                                                                             55.470                                                                             31.765                                                                             1.00                                                                              20.19            1DLC1167                    ATOM  1044                                                                              CG PHE 193                                                                               28.185                                                                             56.011                                                                             30.386                                                                             1.00                                                                              23.31            1DLC1168                    ATOM  1045                                                                              CD1                                                                               PHE 193                                                                               29.016                                                                             55.646                                                                             29.333                                                                             1.00                                                                              20.93            1DLC1169                    ATOM  1046                                                                              CD2                                                                               PHE 193                                                                               27.178                                                                             56.943                                                                             30.151                                                                             1.00                                                                              23.78            1DLC1170                    ATOM  1047                                                                              CE1                                                                               PHE 193                                                                               28.848                                                                             56.205                                                                             28.066                                                                             1.00                                                                              23.90            1DLC1171                    ATOM  1048                                                                              CE2                                                                               PHE 193                                                                               27.005                                                                             57.506                                                                             28.886                                                                             1.00                                                                              25.20            1DLC1172                    ATOM  1049                                                                              CZ PHE 193                                                                               27.842                                                                             57.137                                                                             27.845                                                                             1.00                                                                              20.39            1DLC1173                    ATOM  1050                                                                              N  LEU 194                                                                               28.566                                                                             52.872                                                                             34.065                                                                             1.00                                                                              22.74            1DLC1174                    ATOM  1051                                                                              CA LEU 194                                                                               29.242                                                                             52.536                                                                             35.324                                                                             1.00                                                                              21.21            1DLC1175                    ATOM  1052                                                                              C  LEU 194                                                                               30.634                                                                             51.887                                                                             35.302                                                                             1.00                                                                              21.36            1DLC1176                    ATOM  1053                                                                              O  LEU 194                                                                               31.533                                                                             52.328                                                                             36.019                                                                             1.00                                                                              20.76            1DLC1177                    ATOM  1054                                                                              CB LEU 194                                                                               28.297                                                                             51.768                                                                             36.263                                                                             1.00                                                                              17.75            1DLC1178                    ATOM  1055                                                                              CG LEU 194                                                                               28.574                                                                             51.962                                                                             37.766                                                                             1.00                                                                              16.29            1DLC1179                    ATOM  1056                                                                              CD1                                                                               LEU 194                                                                               28.602                                                                             53.452                                                                             38.103                                                                             1.00                                                                              11.60            1DLC1180                    ATOM  1057                                                                              CD2                                                                               LEU 194                                                                               27.528                                                                             51.257                                                                             38.608                                                                             1.00                                                                              12.55            1DLC1181                    ATOM  1058                                                                              N  THR 195                                                                               30.825                                                                             50.841                                                                             34.507                                                                             1.00                                                                              22.96            1DLC1182                    ATOM  1059                                                                              CA THR 195                                                                               32.140                                                                             50.197                                                                             34.451                                                                             1.00                                                                              22.99            1DLC1183                    ATOM  1060                                                                              C  THR 195                                                                               33.160                                                                             51.083                                                                             33.716                                                                             1.00                                                                              22.92            1DLC1184                    ATOM  1061                                                                              O  THR 195                                                                               34.343                                                                             51.108                                                                             34.061                                                                             1.00                                                                              24.03            1DLC1185                    ATOM  1062                                                                              CB THR 195                                                                               32.067                                                                             48.777                                                                             33.832                                                                             1.00                                                                              22.11            1DLC1186                    ATOM  1063                                                                              OG1                                                                               THR 195                                                                               31.554                                                                             48.855                                                                             32.498                                                                             1.00                                                                              27.92            1DLC1187                    ATOM  1064                                                                              CG2                                                                               THR 195                                                                               31.150                                                                             47.896                                                                             34.663                                                                             1.00                                                                              19.33            1DLC1188                    ATOM  1065                                                                              N  THR 196                                                                               32.681                                                                             51.845                                                                             32.738                                                                             1.00                                                                              19.98            1DLC1189                    ATOM  1066                                                                              CA THR 196                                                                               33.521                                                                             52.768                                                                             31.987                                                                             1.00                                                                              19.69            1DLC1190                    ATOM  1067                                                                              C  THR 196                                                                               33.958                                                                             53.893                                                                             32.925                                                                             1.00                                                                              20.38            1DLC1191                    ATOM  1068                                                                              O  THR 196                                                                               35.132                                                                             54.233                                                                             32.983                                                                             1.00                                                                              25.74            1DLC1192                    ATOM  1069                                                                              CB THR 196                                                                               32.748                                                                             53.374                                                                             30.805                                                                             1.00                                                                              21.39            1DLC1193                    ATOM  1070                                                                              OG1                                                                               THR 196                                                                               32.366                                                                             52.330                                                                             29.903                                                                             1.00                                                                              23.90            1DLC1194                    ATOM  1071                                                                              CG2                                                                               THR 196                                                                               33.598                                                                             54.387                                                                             30.064                                                                             1.00                                                                              22.13            1DLC1195                    ATOM  1072                                                                              N  TYR 197                                                                               33.011                                                                             54.457                                                                             33.671                                                                             1.00                                                                              20.18            1DLC1196                    ATOM  1073                                                                              CA TYR 197                                                                               33.292                                                                             55.529                                                                             34.630                                                                             1.00                                                                              19.63            1DLC1197                    ATOM  1074                                                                              C  TYR 197                                                                               34.236                                                                             55.009                                                                             35.717                                                                             1.00                                                                              21.21            1DLC1198                    ATOM  1075                                                                              O  TYR 197                                                                               35.208                                                                             55.668                                                                             36.072                                                                             1.00                                                                              23.03            1DLC1199                    ATOM  1076                                                                              CB TYR 197                                                                               31.986                                                                             56.019                                                                             35.271                                                                             1.00                                                                              18.30            1DLC1200                    ATOM  1077                                                                              CG TYR 197                                                                               32.119                                                                             57.108                                                                             36.326                                                                             1.00                                                                              14.96            1DLC1201                    ATOM  1078                                                                              CD1                                                                               TYR 197                                                                               32.471                                                                             56.799                                                                             37.639                                                                             1.00                                                                              16.47            1DLC1202                    ATOM  1079                                                                              CD2                                                                               TYR 197                                                                               31.840                                                                             58.443                                                                             36.020                                                                             1.00                                                                              16.19            1DLC1203                    ATOM  1080                                                                              CE1                                                                               TYR 197                                                                               32.540                                                                             57.784                                                                             38.620                                                                             1.00                                                                              16.31            1DLC1204                    ATOM  1081                                                                              CE2                                                                               TYR 197                                                                               31.903                                                                             59.442                                                                             36.995                                                                             1.00                                                                              14.65            1DLC1205                    ATOM  1082                                                                              CZ TYR 197                                                                               32.252                                                                             59.103                                                                             38.296                                                                             1.0C                                                                              18.45            1DLC1206                    ATOM  1083                                                                              OH TYR 197                                                                               32.292                                                                             60.067                                                                             39.287                                                                             1.00                                                                              22.05            1DLC1207                    ATOM  1084                                                                              N  ALA 198                                                                               33.961                                                                             53.815                                                                             36.229                                                                             1.00                                                                              21.80            1DLC1208                    ATOM  1085                                                                              CA ALA 198                                                                               34.793                                                                             53.225                                                                             37.277                                                                             1.00                                                                              21.41            1DLC1209                    ATOM  1086                                                                              C  ALA 198                                                                               36.259                                                                             53.101                                                                             36.852                                                                             1.00                                                                              20.73            1DLC1210                    ATOM  1087                                                                              O  ALA 198                                                                               37.157                                                                             53.523                                                                             37.579                                                                             1.00                                                                              19.18            1DLC1211                    ATOM  1088                                                                              CB GLN 199                                                                               34.239                                                                             51.867                                                                             37.687                                                                             1.00                                                                              21.88            1DLC1212                    ATOM  1089                                                                              N  GLN 199                                                                               36.478                                                                             52.560                                                                             35.654                                                                             1.00                                                                              19.43            1DLC1213                    ATOM  1090                                                                              CA GLN 199                                                                               37.816                                                                             52.374                                                                             35.100                                                                             1.00                                                                              19.21            1DLC1214                    ATOM  1091                                                                              C  GLN 199                                                                               38.515                                                                             53.708                                                                             34.780                                                                             1.00                                                                              21.06            1DLC1215                    ATOM  1092                                                                              O  GLN 199                                                                               39.726                                                                             53.849                                                                             34.969                                                                             1.00                                                                              22.54            1DLC1216                    ATOM  1093                                                                              CB GLN 199                                                                               37.747                                                                             51.488                                                                             33.855                                                                             1.00                                                                              19.94            1DLC1217                    ATOM  1094                                                                              CG GLN 199                                                                               37.211                                                                             50.082                                                                             34.106                                                                             1.00                                                                              21.16            1DLC1218                    ATOM  1095                                                                              CD GLN 199                                                                               38.146                                                                             49.221                                                                             34.949                                                                             1.00                                                                              26.14            1DLC1219                    ATOM  1096                                                                              OE1                                                                               GLN 199                                                                               39.348                                                                             49.465                                                                             35.003                                                                             1.00                                                                              28.88            1DLC1220                    ATOM  1097                                                                              NE2                                                                               GLN 199                                                                               37.594                                                                             48.201                                                                             35.605                                                                             1.00                                                                              26.51            1DLC1221                    ATOM  1098                                                                              N  ALA 200                                                                               37.755                                                                             54.690                                                                             34.309                                                                             1.00                                                                              18.59            1DLC1222                    ATOM  1099                                                                              CA ALA 200                                                                               38.318                                                                             56.002                                                                             34.006                                                                             1.00                                                                              17.37            1DLC1223                    ATOM  1100                                                                              C  ALA 200                                                                               38.668                                                                             56.712                                                                             35.316                                                                             1.00                                                                              19.35            1DLC1224                    ATOM  1101                                                                              O  ALA 200                                                                               39.754                                                                             57.287                                                                             35.455                                                                             1.00                                                                              22.44            1DLC1225                    ATOM  1102                                                                              CB ALA 200                                                                               37.331                                                                             56.827                                                                             33.203                                                                             1.00                                                                              12.83            1DLC1226                    ATOM  1103                                                                              N  ALA 201                                                                               37.762                                                                             56.625                                                                             36.291                                                                             1.00                                                                              21.10            1DLC1227                    ATOM  1104                                                                              CA ALA 201                                                                               37.946                                                                             57.232                                                                             37.612                                                                             1.00                                                                              18.23            1DLC1228                    ATOM  1105                                                                              C  ALA 201                                                                               39.206                                                                             56.667                                                                             38.259                                                                             1.00                                                                              18.71            1DLC1229                    ATOM  1106                                                                              O  ALA 201                                                                               40.045                                                                             57.404                                                                             38.769                                                                             1.00                                                                              22.55            1DLC1230                    ATOM  1107                                                                              CB ALA 201                                                                               36.737                                                                             56.948                                                                             38.497                                                                             1.00                                                                              14.73            1DLC1231                    ATOM  1108                                                                              N  ASN 202                                                                               39.342                                                                             55.349                                                                             38.211                                                                             1.00                                                                              18.93            1DLC1232                    ATOM  1109                                                                              CA ASN 202                                                                               40.506                                                                             54.674                                                                             38.773                                                                             1.00                                                                              19.98            1DLC1233                    ATOM  1110                                                                              C  ASN 202                                                                               41.795                                                                             55.231                                                                             38.172                                                                             1.00                                                                              20.62            1DLC1234                    ATOM  1111                                                                              O  ASN 202                                                                               42.723                                                                             55.601                                                                             38.897                                                                             1.00                                                                              20.33            1DLC1235                    ATOM  1112                                                                              CB ASN 202                                                                               40.418                                                                             53.172                                                                             38.501                                                                             1.00                                                                              19.83            1DLC1236                    ATOM  1113                                                                              CG ASN 202                                                                               41.612                                                                             52.418                                                                             39.032                                                                             1.00                                                                              19.77            1DLC1237                    ATOM  1114                                                                              DD1                                                                               ASN 202                                                                               42.334                                                                             51.761                                                                             38.278                                                                             1.00                                                                              23.18            1DLC1238                    ATOM  1115                                                                              ND2                                                                               ASN 202                                                                               41.835                                                                             52.509                                                                             40.332                                                                             1.00                                                                              14.55            1DLC1239                    ATOM  1116                                                                              N  THR 203                                                                               41.842                                                                             55.287                                                                             36.844                                                                             1.00                                                                              21.70            1DLC1240                    ATOM  1117                                                                              CA THR 203                                                                               43.007                                                                             55.805                                                                             36.138                                                                             1.00                                                                              22.47            1DLC1241                    ATOM  1118                                                                              C  THR 203                                                                               43.322                                                                             57.223                                                                             36.631                                                                             1.00                                                                              23.03            1DLC1242                    ATOM  1119                                                                              O  THR 203                                                                               44.428                                                                             57.496                                                                             37.091                                                                             1.00                                                                              24.63            1DLC1243                    ATOM  1120                                                                              CB THR 203                                                                               42.789                                                                             55.827                                                                             34.593                                                                             1.00                                                                              24.20            1DLC1244                    ATOM  1121                                                                              DG1                                                                               THR 203                                                                               42.470                                                                             54.507                                                                             34.123                                                                             1.00                                                                              17.39            1DLC1245                    ATOM  1122                                                                              CG2                                                                               THR 203                                                                               44.058                                                                             56.319                                                                             33.877                                                                             1.00                                                                              22.82            1DLC1246                    ATOM  1123                                                                              N  HIS 204                                                                               42.318                                                                             58.091                                                                             36.619                                                                             1.00                                                                              20.16            1DLC1247                    ATOM  1124                                                                              CA HIS 204                                                                               42.485                                                                             59.468                                                                             37.064                                                                             1.00                                                                              18.30            1DLC1248                    ATOM  1125                                                                              C  HIS 204                                                                               43.123                                                                             59.566                                                                             38.451                                                                             1.00                                                                              19.42            1DLC1249                    ATOM  1126                                                                              O  HIS 204                                                                               44.064                                                                             60.328                                                                             38.651                                                                             1.00                                                                              23.12            1DLC1250                    ATOM  1127                                                                              CB HIS 204                                                                               41.131                                                                             60.190                                                                             37.066                                                                             1.00                                                                              15.98            1DLC1251                    ATOM  1128                                                                              CG HIS 204                                                                               41.224                                                                             61.664                                                                             37.314                                                                             1.00                                                                              15.26            1DLC1252                    ATOM  1129                                                                              ND1                                                                               HIS 204                                                                               40.123                                                                             62.443                                                                             37.582                                                                             1.00                                                                              18.22            1DLC1253                    ATOM  1130                                                                              CD2                                                                               HIS 204                                                                               42.285                                                                             62.508                                                                             37.302                                                                             1.00                                                                              14.66            1DLC1254                    ATOM  1131                                                                              CE1                                                                               HIS 204                                                                               40.495                                                                             63.703                                                                             37.719                                                                             1.00                                                                              17.73            1DLC1255                    ATOM  1132                                                                              NE2                                                                               HIS 204                                                                               41.803                                                                             63.768                                                                             37.554                                                                             1.00                                                                              15.61            1DLC1256                    ATOM  1133                                                                              N  LEU 205                                                                               42.603                                                                             58.810                                                                             39.410                                                                             1.00                                                                              19.20            1DLC1257                    ATOM  1134                                                                              CA LEU 205                                                                               43.131                                                                             58.845                                                                             40.772                                                                             1.00                                                                              19.71            1DLC1258                    ATOM  1135                                                                              C  LEU 205                                                                               44.519                                                                             58.227                                                                             40.904                                                                             1.00                                                                              21.25            1DLC1259                    ATOM  1136                                                                              O  LEU 205                                                                               45.356                                                                             58.725                                                                             41.666                                                                             1.00                                                                              21.63            1DLC1260                    ATOM  1137                                                                              CB LEU 205                                                                               42.168                                                                             58.161                                                                             41.745                                                                             1.00                                                                              18.84            1DLC1261                    ATOM  1138                                                                              CG LEU 205                                                                               40.886                                                                             58.921                                                                             42.052                                                                             1.00                                                                              18.00            1DLC1262                    ATOM  1139                                                                              CD1                                                                               LEU 205                                                                               40.010                                                                             58.052                                                                             42.908                                                                             1.00                                                                              20.41            1DLC1263                    ATOM  1140                                                                              CD2                                                                               LEU 205                                                                               41.197                                                                             60.226                                                                             42.759                                                                             1.00                                                                              18.32            1DLC1264                    ATOM  1141                                                                              N  PHE 206                                                                               44.761                                                                             57.137                                                                             40.177                                                                             1.00                                                                              20.18            1DLC1265                    ATOM  1142                                                                              CA PHE 206                                                                               46.060                                                                             56.477                                                                             40.233                                                                             1.00                                                                              20.34            1DLC1266                    ATOM  1143                                                                              C  PHE 206                                                                               47.117                                                                             57.423                                                                             39.677                                                                             1.00                                                                              20.04            1DLC1267                    ATOM  1144                                                                              O  PHE 206                                                                               48.221                                                                             57.522                                                                             40.192                                                                             1.00                                                                              21.09            1DLC1268                    ATOM  1145                                                                              CB PHE 206                                                                               46.051                                                                             55.175                                                                             39.438                                                                             1.00                                                                              18.45            1DLC1269                    ATOM  1146                                                                              CG PHE 206                                                                               47.169                                                                             54.263                                                                             39.798                                                                             1.00                                                                              16.28            1DLC1270                    ATOM  1147                                                                              CD1                                                                               PHE 206                                                                               47.221                                                                             53.683                                                                             41.063                                                                             1.00                                                                              14.90            1DLC1271                    ATOM  1148                                                                              CD2                                                                               PHE 206                                                                               48.196                                                                             54.006                                                                             38.897                                                                             1.00                                                                              16.65            1DLC1272                    ATOM  1149                                                                              CE1                                                                               PHE 206                                                                               48.279                                                                             52.863                                                                             41.423                                                                             1.00                                                                              15.74            1DLC1273                    ATOM  1150                                                                              CE2                                                                               PHE 206                                                                               49.259                                                                             53.185                                                                             39.247                                                                             1.00                                                                              14.95            1DLC1274                    ATOM  1151                                                                              CZ PHE 206                                                                               49.303                                                                             52.612                                                                             40.510                                                                             1.00                                                                              13.30            1DLC1275                    ATOM  1152                                                                              N  LEU 207                                                                               46.737                                                                             58.124                                                                             38.621                                                                             1.00                                                                              21.24            1DLC1276                    ATOM  1153                                                                              CA LEU 207                                                                               47.575                                                                             59.112                                                                             37.955                                                                             1.00                                                                              22.23            1DLC1277                    ATOM  1154                                                                              C  LEU 207                                                                               47.927                                                                             60.224                                                                             38.966                                                                             1.00                                                                              23.44            1DLC1278                    ATOM  1155                                                                              O  LEU 207                                                                               49.098                                                                             60.547                                                                             39.190                                                                             1.00                                                                              22.70            1DLC1279                    ATOM  1156                                                                              CB LEU 207                                                                               46.758                                                                             59.698                                                                             36.801                                                                             1.00                                                                              23.02            1DLC1280                    ATOM  1157                                                                              CG LEU 207                                                                               47.360                                                                             60.368                                                                             35.571                                                                             1.00                                                                              31.73            1DLC1281                    ATOM  1158                                                                              CD1                                                                               LEU 207                                                                               47.968                                                                             61.698                                                                             35.942                                                                             1.00                                                                              33.70            1DLC1282                    ATOM  1159                                                                              CD2                                                                               LEU 207                                                                               48.369                                                                             59.439                                                                             34.915                                                                             1.00                                                                              34.96            1DLC1283                    ATOM  1160                                                                              N  LEU 208                                                                               46.894                                                                             60.762                                                                             39.610                                                                             1.00                                                                              22.59            1DLC1284                    ATOM  1161                                                                              CA LEU 208                                                                               47.044                                                                             61.837                                                                             40.584                                                                             1.00                                                                              20.00            1DLC1285                    ATOM  1162                                                                              C  LEU 208                                                                               48.056                                                                             61.607                                                                             41.704                                                                             1.00                                                                              20.94            1DLC1286                    ATOM  1163                                                                              O  LEU 208                                                                               48.819                                                                             62.514                                                                             42.046                                                                             1.00                                                                              22.20            1DLC1287                    ATOM  1164                                                                              CB LEU 208                                                                               45.686                                                                             62.194                                                                             41.188                                                                             1.00                                                                              16.43            1DLC1288                    ATOM  1165                                                                              CG LEU 208                                                                               44.872                                                                             63.256                                                                             40.452                                                                             1.00                                                                              17.48            1DLC1289                    ATOM  1166                                                                              CD1                                                                               LEU 208                                                                               43.449                                                                             63.277                                                                             40.998                                                                             1.00                                                                              19.96            1DLC1290                    ATOM  1167                                                                              CD2                                                                               LEU 208                                                                               45.527                                                                             64.630                                                                             40.597                                                                             1.00                                                                              13.67            1DLC1291                    ATOM  1168                                                                              N  LYS 209                                                                               48.073                                                                             60.410                                                                             42.282                                                                             1.00                                                                              20.58            1DLC1292                    ATOM  1169                                                                              CA LYS 209                                                                               48.998                                                                             60.137                                                                             43.378                                                                             1.00                                                                              20.54            1DLC1293                    ATOM  1170                                                                              C  LYS 209                                                                               50.479                                                                             60.260                                                                             42.979                                                                             1.00                                                                              23.16            1DLC1294                    ATOM  1171                                                                              O  LYS 209                                                                               51.335                                                                             60.554                                                                             43.821                                                                             1.00                                                                              23.16            1DLC1295                    ATOM  1172                                                                              CB LYS 209                                                                               48.672                                                                             58.798                                                                             44.057                                                                             1.00                                                                              16.68            1DLC1296                    ATOM  1173                                                                              CG LYS 209                                                                               48.825                                                                             57.563                                                                             43.202                                                                             1.00                                                                              18.68            1DLC1297                    ATOM  1174                                                                              CD LYS 209                                                                               50.232                                                                             57.019                                                                             43.295                                                                             1.00                                                                              18.58            1DLC1298                    ATOM  1175                                                                              CE LYS 209                                                                               50.369                                                                             55.683                                                                             42.589                                                                             1.00                                                                              21.11            1DLC1299                    ATOM  1176                                                                              NZ LYS 209                                                                               50.185                                                                             55.764                                                                             41.111                                                                             1.00                                                                              21.88            1DLC1300                    ATOM  1177                                                                              N  ASP 210                                                                               50.763                                                                             60.130                                                                             41.684                                                                             1.00                                                                              21.08            1DLC1301                    ATOM  1178                                                                              CA ASP 210                                                                               52.131                                                                             60.261                                                                             41.191                                                                             1.00                                                                              19.70            1DLC1302                    ATOM  1179                                                                              C  ASP 210                                                                               52.703                                                                             61.647                                                                             41.503                                                                             1.00                                                                              20.97            1DLC1303                    ATOM  1180                                                                              O  ASP 210                                                                               53.907                                                                             61.798                                                                             41.741                                                                             1.00                                                                              21.99            1DLC1304                    ATOM  1181                                                                              CB ASP 210                                                                               52.193                                                                             59.982                                                                             39.689                                                                             1.00                                                                              19.34            1DLC1305                    ATOM  1182                                                                              CG ASP 210                                                                               52.109                                                                             58.504                                                                             39.366                                                                             1.00                                                                              19.19            1DLC1306                    ATOM  1183                                                                              OD1                                                                               ASP 210                                                                               51.971                                                                             57.689                                                                             40.298                                                                             1.00                                                                              19.56            1DLC1307                    ATOM  1184                                                                              OD2                                                                               ASP 210                                                                               52.205                                                                             58.153                                                                             38.178                                                                             1.00                                                                              21.76            1DLC1308                    ATOM  1185                                                                              N  ALA 211                                                                               51.829                                                                             62.650                                                                             41.540                                                                             1.00                                                                              19.23            1DLC1309                    ATOM  1186                                                                              CA ALA 211                                                                               52.241                                                                             64.015                                                                             41.858                                                                             1.00                                                                              19.70            1DLC1310                    ATOM  1187                                                                              C  ALA 211                                                                               52.795                                                                             64.116                                                                             43.287                                                                             1.00                                                                              19.61            1DLC1311                    ATOM  1188                                                                              O  ALA 211                                                                               53.601                                                                             64.990                                                                             43.583                                                                             1.00                                                                              22.55            1DLC1312                    ATOM  1189                                                                              CB ALA 211                                                                               51.072                                                                             64.979                                                                             41.680                                                                             1.00                                                                              15.73            1DLC1313                    ATOM  1190                                                                              N  GLN 212                                                                               52.365                                                                             63.227                                                                             44.177                                                                             1.00                                                                              18.98            1DLC1314                    ATOM  1191                                                                              CA GLN 212                                                                               52.856                                                                             63.265                                                                             45.557                                                                             1.00                                                                              19.82            1DLC1315                    ATOM  1192                                                                              C  GLN 212                                                                               54.149                                                                             62.482                                                                             45.687                                                                             1.00                                                                              19.72            1DLC1316                    ATOM  1193                                                                              O  GLN 212                                                                               54.903                                                                             62.674                                                                             46.632                                                                             1.00                                                                              22.58            1DLC1317                    ATOM  1194                                                                              CB GLN 212                                                                               51.819                                                                             62.718                                                                             46.556                                                                             1.00                                                                              15.61            1DLC1318                    ATOM  1195                                                                              CG GLN 212                                                                               50.456                                                                             63.394                                                                             46.496                                                                             1.00                                                                              12.71            1DLC1319                    ATOM  1196                                                                              CD GLN 212                                                                               50.538                                                                             64.903                                                                             46.573                                                                             1.00                                                                              12.86            1DLC1320                    ATOM  1197                                                                              OE1                                                                               GLN 212                                                                               51.103                                                                             65.454                                                                             47.503                                                                             1.00                                                                              14.37            1DLC1321                    ATOM  1198                                                                              NE2                                                                               GLN 212                                                                               49.964                                                                             65.578                                                                             45.593                                                                             1.00                                                                              10.00            1DLC1322                    ATOM  1199                                                                              N  ILE 213                                                                               54.389                                                                             61.582                                                                             44.741                                                                             1.00                                                                              22.18            1DLC1323                    ATOM  1200                                                                              CA ILE 213                                                                               55.594                                                                             60.767                                                                             44.752                                                                             1.00                                                                              20.68            1DLC1324                    ATOM  1201                                                                              C  ILE 213                                                                               56.754                                                                             61.481                                                                             44.057                                                                             1.00                                                                              22.54            1DLC1325                    ATOM  1202                                                                              O  ILE 213                                                                               57.836                                                                             61.622                                                                             44.623                                                                             1.00                                                                              23.78            1DLC1326                    ATOM  1203                                                                              CB ILE 213                                                                               55.356                                                                             59.419                                                                             44.054                                                                             1.00                                                                              20.69            1DLC1327                    ATOM  1204                                                                              CG1                                                                               ILE 213                                                                               54.347                                                                             58.579                                                                             44.840                                                                             1.00                                                                              17.63            1DLC1328                    ATOM  1205                                                                              CG2                                                                               ILE 213                                                                               56.670                                                                             58.666                                                                             43.909                                                                             1.00                                                                              25.19            1DLC1329                    ATOM  1206                                                                              CD1                                                                               ILE 213                                                                               54.045                                                                             57.240                                                                             44.188                                                                             1.00                                                                              12.68            1DLC1330                    ATOM  1207                                                                              N  TYR 214                                                                               56.508                                                                             61.952                                                                             42.838                                                                             1.00                                                                              23.00            1DLC1331                    ATOM  1208                                                                              CA TYR 214                                                                               57.528                                                                             62.631                                                                             42.043                                                                             1.00                                                                              22.33            1DLC1332                    ATOM  1209                                                                              C  TYR 214                                                                               57.425                                                                             64.154                                                                             41.979                                                                             1.00                                                                              24.14            1DLC1333                    ATOM  1210                                                                              O  TYR 214                                                                               58.269                                                                             64.801                                                                             41.374                                                                             1.00                                                                              28.23            1DLC1334                    ATOM  1211                                                                              CB TYR 214                                                                               57.488                                                                             62.100                                                                             40.615                                                                             1.00                                                                              23.32            1DLC1335                    ATOM  1212                                                                              CG TYR 214                                                                               57.727                                                                             60.620                                                                             40.479                                                                             1.00                                                                              26.06            1DLC1336                    ATOM  1213                                                                              CD1                                                                               TYR 214                                                                               59.009                                                                             60.092                                                                             40.618                                                                             1.00                                                                              27.10            1DLC1337                    ATOM  1214                                                                              CD2                                                                               TYR 214                                                                               56.678                                                                             59.746                                                                             40.184                                                                             1.00                                                                              25.78            1DLC1338                    ATOM  1215                                                                              CE1                                                                               TYR 214                                                                               59.249                                                                             58.728                                                                             40.466                                                                             1.00                                                                              32.00            1DLC1339                    ATOM  1216                                                                              CE2                                                                               TYR 214                                                                               56.907                                                                             58.374                                                                             40.026                                                                             1.00                                                                              31.14            1DLC1340                    ATOM  1217                                                                              CZ TYR 214                                                                               58.199                                                                             57.874                                                                             40.169                                                                             1.00                                                                              32.77            1DLC1341                    ATOM  1218                                                                              OH TYR 214                                                                               58.452                                                                             56.529                                                                             40.017                                                                             1.00                                                                              37.11            1DLC1342                    ATOM  1219                                                                              N  GLY 215                                                                               56.398                                                                             64.724                                                                             42.596                                                                             1.00                                                                              25.34            1DLC1343                    ATOM  1220                                                                              CA GLY 215                                                                               56.198                                                                             66.166                                                                             42.560                                                                             1.00                                                                              27.83            1DLC1344                    ATOM  1221                                                                              C  GLY 215                                                                               57.419                                                                             67.067                                                                             42.648                                                                             1.00                                                                              29.47            1DLC1345                    ATOM  1222                                                                              O  GLY 215                                                                               57.663                                                                             67.867                                                                             41.746                                                                             1.00                                                                              28.30            1DLC1346                    ATOM  1223                                                                              N  GLU 216                                                                               58.174                                                                             66.954                                                                             43.737                                                                             1.00                                                                              32.54            1DLC1347                    ATOM  1224                                                                              CA GLU 216                                                                               59.368                                                                             67.769                                                                             43.918                                                                             1.00                                                                              36.48            1DLC1348                    ATOM  1225                                                                              C  GLU 216                                                                               60.485                                                                             67.450                                                                             42.917                                                                             1.00                                                                              35.87            1DLC1349                    ATOM  1226                                                                              O  GLU 216                                                                               61.148                                                                             68.358                                                                             42.427                                                                             1.00                                                                              36.74            1DLC1350                    ATOM  1227                                                                              CB GLU 216                                                                               59.878                                                                             67.676                                                                             45.351                                                                             1.00                                                                              41.84            1DLC1351                    ATOM  1228                                                                              CG GLU 216                                                                               58.947                                                                             68.318                                                                             46.371                                                                             1.00                                                                              54.52            1DLC1352                    ATOM  1229                                                                              CD GLU 216                                                                               59.656                                                                             68.698                                                                             47.671                                                                             1.00                                                                              64.18            1DLC1353                    ATOM  1230                                                                              OE1                                                                               GLU 216                                                                               60.560                                                                             67.944                                                                             48.116                                                                             1.00                                                                              67.77            1DLC1354                    ATOM  1231                                                                              OE2                                                                               GLU 216                                                                               59.311                                                                             69.764                                                                             48.244                                                                             1.00                                                                              67.98            1DLC1355                    ATOM  1232                                                                              N  GLU 217                                                                               60.665                                                                             66.172                                                                             42.591                                                                             1.00                                                                              34.29            1DLC1356                    ATOM  1233                                                                              CA GLU 217                                                                               61.682                                                                             65.750                                                                             41.623                                                                             1.00                                                                              33.09            1DLC1357                    ATOM  1234                                                                              C  GLU 217                                                                               61.440                                                                             66.442                                                                             40.282                                                                             1.00                                                                              33.15            1DLC1358                    ATOM  1235                                                                              O  GLU 217                                                                               62.376                                                                             66.884                                                                             39.619                                                                             1.00                                                                              34.29            1DLC1359                    ATOM  1236                                                                              CB GLU 217                                                                               61.617                                                                             64.238                                                                             41.385                                                                             1.00                                                                              36.76            1DLC1360                    ATOM  1237                                                                              CG GLU 217                                                                               61.993                                                                             63.362                                                                             42.565                                                                             1.00                                                                              36.91            1DLC1361                    ATOM  1238                                                                              CD GLU 217                                                                               62.121                                                                             61.887                                                                             42.182                                                                             1.00                                                                              39.24            1DLC1362                    ATOM  1239                                                                              OE1                                                                               GLU 217                                                                               61.938                                                                             61.540                                                                             40.993                                                                             1.00                                                                              37.21            1DLC1363                    ATOM  1240                                                                              OE2                                                                               GLU 217                                                                               62.416                                                                             61.067                                                                             43.074                                                                             1.00                                                                              42.79            1DLC1364                    ATOM  1241                                                                              N  TRP 218                                                                               60.172                                                                             66.488                                                                             39.878                                                                             1.00                                                                              31.27            1DLC1365                    ATOM  1242                                                                              CA TRP 218                                                                               59.756                                                                             67.116                                                                             38.627                                                                             1.00                                                                              25.69            1DLC1366                    ATOM  1243                                                                              C  TRP 218                                                                               59.846                                                                             68.638                                                                             38.714                                                                             1.00                                                                              22.53            1DLC1367                    ATOM  1244                                                                              O  TRP 218                                                                               59.670                                                                             69.330                                                                             37.722                                                                             1.00                                                                              23.72            1DLC1368                    ATOM  1245                                                                              CB TRP 218                                                                               58.312                                                                             66.720                                                                             38.282                                                                             1.00                                                                              26.69            1DLC1369                    ATOM  1246                                                                              CG TRP 218                                                                               58.097                                                                             65.248                                                                             37.980                                                                             1.00                                                                              26.77            1DLC1370                    ATOM  1247                                                                              CD1                                                                               TRP 218                                                                               59.051                                                                             64.322                                                                             37.664                                                                             1.00                                                                              28.09            1DLC1371                    ATOM  1248                                                                              CD2                                                                               TRP 218                                                                               56.840                                                                             64.549                                                                             37.961                                                                             1.00                                                                              25.69            1DLC1372                    ATOM  1249                                                                              NE1                                                                               TRP 218                                                                               58.468                                                                             63.093                                                                             37.449                                                                             1.00                                                                              28.06            1DLC1373                    ATOM  1250                                                                              CE2                                                                               TRP 218                                                                               57.114                                                                             63.203                                                                             37.626                                                                             1.00                                                                              26.57            1DLC1374                    ATOM  1251                                                                              CE3                                                                               TRP 218                                                                               55.512                                                                             64.929                                                                             38.196                                                                             1.00                                                                              22.74            1DLC1375                    ATOM  1252                                                                              CZ2                                                                               TRP 218                                                                               56.102                                                                             62.235                                                                             37.519                                                                             1.00                                                                              25.71            1DLC1376                    ATOM  1253                                                                              CZ3                                                                               TRP 218                                                                               54.511                                                                             63.967                                                                             38.089                                                                             1.00                                                                              21.96            1DLC1377                    ATOM  1254                                                                              CH2                                                                               TRP 218                                                                               54.813                                                                             62.637                                                                             37.755                                                                             1.00                                                                              22.35            1DLC1378                    ATOM  1255                                                                              N  GLY 219                                                                               60.088                                                                             69.160                                                                             39.910                                                                             1.00                                                                              21.50            1DLC1379                    ATOM  1256                                                                              CA GLY 219                                                                               60.192                                                                             70.595                                                                             40.068                                                                             1.00                                                                              22.27            1DLC1380                    ATOM  1257                                                                              C  GLY 219                                                                               58.871                                                                             71.338                                                                             40.117                                                                             1.00                                                                              27.62            1DLC1381                    ATOM  1258                                                                              O  GLY 219                                                                               58.757                                                                             72.444                                                                             39.593                                                                             1.00                                                                              31.08            1DLC1382                    ATOM  1259                                                                              N  TYR 220                                                                               57.852                                                                             70.712                                                                             40.696                                                                             1.00                                                                              30.00            1DLC1383                    ATOM  1260                                                                              CA TYR 220                                                                               56.543                                                                             71.343                                                                             40.843                                                                             1.00                                                                              26.76            1DLC1384                    ATOM  1261                                                                              C  TYR 220                                                                               56.611                                                                             72.221                                                                             42.088                                                                             1.00                                                                              28.73            1DLC1385                    ATOM  1262                                                                              O  TYR 220                                                                               57.304                                                                             71.886                                                                             43.054                                                                             1.00                                                                              27.48            1DLC1386                    ATOM  1263                                                                              CB TYR 220                                                                               55.453                                                                             70.289                                                                             41.076                                                                             1.00                                                                              27.42            1DLC1387                    ATOM  1264                                                                              CG TYR 220                                                                               54.625                                                                             69.913                                                                             39.873                                                                             1.00                                                                              23.12            1DLC1388                    ATOM  1265                                                                              CD1                                                                               TYR 220                                                                               53.951                                                                             70.881                                                                             39.130                                                                             1.00                                                                              21.42            1DLC1389                    ATOM  1266                                                                              CD2                                                                               TYR 220                                                                               54.487                                                                             68.576                                                                             39.496                                                                             1.00                                                                              23.42            1DLC1390                    ATOM  1267                                                                              CE1                                                                               TYR 220                                                                               53.152                                                                             70.521                                                                             38.034                                                                             1.00                                                                              22.62            1DLC1391                    ATOM  1268                                                                              CE2                                                                               TYR 220                                                                               53.698                                                                             68.207                                                                             38.413                                                                             1.00                                                                              20.38            1DLC1392                    ATOM  1269                                                                              CZ TYR 220                                                                               53.033                                                                             69.178                                                                             37.685                                                                             1.00                                                                              22.10            1DLC1393                    ATOM  1270                                                                              OH TYR 220                                                                               52.252                                                                             68.802                                                                             36.617                                                                             1.00                                                                              23.88            1DLC1394                    ATOM  1271                                                                              N  GLU 221                                                                               55.870                                                                             73.324                                                                             42.080                                                                             1.00                                                                              30.82            1DLC1395                    ATOM  1272                                                                              CA GLU 221                                                                               55.825                                                                             74.225                                                                             43.233                                                                             1.00                                                                              32.66            1DLC1396                    ATOM  1273                                                                              C  GLU 221                                                                               55.123                                                                             73.517                                                                             44.398                                                                             1.00                                                                              30.03            1DLC1397                    ATOM  1274                                                                              O  GLU 221                                                                               54.287                                                                             72.638                                                                             44.182                                                                             1.00                                                                              27.72            1DLC1398                    ATOM  1275                                                                              CB GLU 221                                                                               55.023                                                                             75.492                                                                             42.894                                                                             1.00                                                                              38.56            1DLC1399                    ATOM  1276                                                                              CG GLU 221                                                                               55.470                                                                             76.271                                                                             41.656                                                                             1.00                                                                              43.49            1DLC1400                    ATOM  1277                                                                              CD GLU 221                                                                               56.855                                                                             76.898                                                                             41.791                                                                             1.00                                                                              48.97            1DLC1401                    ATOM  1278                                                                              OE1                                                                               GLU 221                                                                               57.330                                                                             77.133                                                                             42.935                                                                             1.00                                                                              48.86            1DLC1402                    ATOM  1279                                                                              OE2                                                                               GLU 221                                                                               57.468                                                                             77.163                                                                             40.730                                                                             1.00                                                                              52.79            1DLC1403                    ATOM  1280                                                                              N  LYS 222                                                                               55.454                                                                             73.909                                                                             45.624                                                                             1.00                                                                              30.89            1DLC1404                    ATOM  1281                                                                              CA LYS 222                                                                               54.823                                                                             73.341                                                                             46.823                                                                             1.00                                                                              33.36            1DLC1405                    ATOM  1282                                                                              C  LYS 222                                                                               53.298                                                                             73.481                                                                             46.711                                                                             1.00                                                                              33.05            1DLC1406                    ATOM  1283                                                                              O  LYS 222                                                                               52.553                                                                             72.577                                                                             47.082                                                                             1.00                                                                              33.57            1DLC1407                    ATOM  1284                                                                              CB LYS 222                                                                               55.281                                                                             74.096                                                                             48.072                                                                             1.00                                                                              36.59            1DLC1408                    ATOM  1285                                                                              CG LYS 222                                                                               56.696                                                                             73.829                                                                             48.528                                                                             1.00                                                                              41.95            1DLC1409                    ATOM  1286                                                                              CD LYS 222                                                                               56.774                                                                             72.524                                                                             49.300                                                                             1.00                                                                              52.08            1DLC1410                    ATOM  1287                                                                              CE LYS 222                                                                               57.623                                                                             72.678                                                                             50.563                                                                             1.00                                                                              56.91            1DLC1411                    ATOM  1288                                                                              NZ LYS 222                                                                               57.030                                                                             73.645                                                                             51.546                                                                             1.00                                                                              59.58            1DLC1412                    ATOM  1289                                                                              N  GLU 223                                                                               52.865                                                                             74.631                                                                             46.188                                                                             1.00                                                                              31.86            1DLC1413                    ATOM  1290                                                                              CA GLU 223                                                                               51.453                                                                             74.964                                                                             45.985                                                                             1.00                                                                              30.30            1DLC1414                    ATOM  1291                                                                              C  GLU 223                                                                               50.767                                                                             74.012                                                                             45.016                                                                             1.00                                                                              28.77            1DLC1415                    ATOM  1292                                                                              O  GLU 223                                                                               49.592                                                                             73.689                                                                             45.192                                                                             1.00                                                                              30.14            1DLC1416                    ATOM  1293                                                                              CB GLU 223                                                                               51.303                                                                             76.382                                                                             45.430                                                                             1.00                                                                              32.15            1DLC1417                    ATOM  1294                                                                              CG GLU 223                                                                               51.827                                                                             77.493                                                                             46.326                                                                             1.00                                                                              39.10            1DLC1418                    ATOM  1295                                                                              CD GLU 223                                                                               53.302                                                                             77.826                                                                             46.105                                                                             1.00                                                                              39.68            1DLC1419                    ATOM  1296                                                                              OE1                                                                               GLU 223                                                                               53.980                                                                             77.137                                                                             45.315                                                                             1.00                                                                              36.48            1DLC1420                    ATOM  1297                                                                              OE2                                                                               GLU 223                                                                               53.777                                                                             78.807                                                                             46.719                                                                             1.00                                                                              44.29            1DLC1421                    ATOM  1298                                                                              N  ASP 224                                                                               51.488                                                                             73.622                                                                             43.964                                                                             1.00                                                                              26.06            1DLC1422                    ATOM  1299                                                                              CA ASP 224                                                                               50.975                                                                             72.702                                                                             42.946                                                                             1.00                                                                              26.67            1DLC1423                    ATOM  1300                                                                              C  ASP 224                                                                               50.699                                                                             71.311                                                                             43.509                                                                             1.00                                                                              25.47            1DLC1424                    ATOM  1301                                                                              O  ASP 224                                                                               49.610                                                                             70.763                                                                             43.347                                                                             1.00                                                                              26.25            1DLC1425                    ATOM  1302                                                                              CB ASP 224                                                                               51.964                                                                             72.578                                                                             41.787                                                                             1.00                                                                              29.40            1DLC1426                    ATOM  1303                                                                              CG ASP 224                                                                               52.088                                                                             73.860                                                                             40.979                                                                             1.00                                                                              38.45            1DLC1427                    ATOM  1304                                                                              OD1                                                                               ASP 224                                                                               51.145                                                                             74.677                                                                             40.990                                                                             1.00                                                                              38.89            1DLC1428                    ATOM  1305                                                                              OD2                                                                               ASP 224                                                                               53.134                                                                             74.052                                                                             40.319                                                                             1.00                                                                              45.08            1DLC1429                    ATOM  1306                                                                              N  ILE 225                                                                               51.684                                                                             70.762                                                                             44.205                                                                             1.00                                                                              21.39            1DLC1430                    ATOM  1307                                                                              CA ILE 225                                                                               51.565                                                                             69.439                                                                             44.792                                                                             1.00                                                                              21.79            1DLC1431                    ATOM  1308                                                                              C  ILE 225                                                                               50.400                                                                             69.397                                                                             45.784                                                                             1.00                                                                              20.00            1DLC1432                    ATOM  1309                                                                              O  ILE 225                                                                               49.636                                                                             68.438                                                                             45.813                                                                             1.00                                                                              19.14            1DLC1433                    ATOM  1310                                                                              CB ILE 225                                                                               52.901                                                                             69.030                                                                             45.465                                                                             1.00                                                                              20.50            1DLC1434                    ATOM  1311                                                                              CG1                                                                               ILE 225                                                                               54.034                                                                             69.121                                                                             44.438                                                                             1.00                                                                              21.29            1DLC1435                    ATOM  1312                                                                              CG2                                                                               ILE 225                                                                               52.819                                                                             67.608                                                                             46.001                                                                             1.00                                                                              20.23            1DLC1436                    ATOM  1313                                                                              CD1                                                                               ILE 225                                                                               55.407                                                                             69.056                                                                             45.037                                                                             1.00                                                                              21.75            1DLC1437                    ATOM  1314                                                                              N  ALA 226                                                                               50.239                                                                             70.479                                                                             46.538                                                                             1.00                                                                              19.79            1DLC1438                    ATOM  1315                                                                              CA ALA 226                                                                               49.166                                                                             70.610                                                                             47.524                                                                             1.00                                                                              20.24            1DLC1439                    ATOM  1316                                                                              C  ALA 226                                                                               47.782                                                                             70.704                                                                             46.854                                                                             1.00                                                                              21.11            1DLC1440                    ATOM  1317                                                                              O  ALA 226                                                                               46.799                                                                             70.134                                                                             47.341                                                                             1.00                                                                              18.19            1DLC1441                    ATOM  1318                                                                              CB ALA 226                                                                               49.414                                                                             71.836                                                                             48.403                                                                             1.00                                                                              16.06            1DLC1442                    ATOM  1319                                                                              N  GLU 227                                                                               47.711                                                                             71.436                                                                             45.744                                                                             1.00                                                                              19.52            1DLC1443                    ATOM  1320                                                                              CA GLU 227                                                                               46.460                                                                             71.572                                                                             45.019                                                                             1.00                                                                              19.61            1DLC1444                    ATOM  1321                                                                              C  GLU 227                                                                               46.075                                                                             70.210                                                                             44.465                                                                             1.00                                                                              21.10            1DLC1445                    ATOM  1322                                                                              O  GLU 227                                                                               44.900                                                                             69.838                                                                             44.492                                                                             1.00                                                                              26.53            1DLC1446                    ATOM  1323                                                                              CB GLU 227                                                                               46.584                                                                             72.584                                                                             43.885                                                                             1.00                                                                              19.91            1DLC1447                    ATOM  1324                                                                              CG GLU 227                                                                               45.303                                                                             72.736                                                                             43.075                                                                             1.00                                                                              21.72            1DLC1448                    ATOM  1325                                                                              CD GLU 227                                                                               45.386                                                                             73.811                                                                             42.014                                                                             1.00                                                                              26.65            1DLC1449                    ATOM  1326                                                                              OE1                                                                               GLU 227                                                                               46.212                                                                             74.736                                                                             42.159                                                                             1.00                                                                              30.03            1DLC1450                    ATOM  1327                                                                              OE2                                                                               GLU 227                                                                               44.613                                                                             73.734                                                                             41.033                                                                             1.00                                                                              27.79            1DLC1451                    ATOM  1328                                                                              N  PHE 228                                                                               47.068                                                                             69.460                                                                             43.987                                                                             1.00                                                                              20.19            1DLC1452                    ATOM  1329                                                                              CA PHE 228                                                                               46.832                                                                             68.114                                                                             43.456                                                                             1.00                                                                              18.86            1DLC1453                    ATOM  1330                                                                              C  PHE 228                                                                               46.335                                                                             67.182                                                                             44.569                                                                             1.00                                                                              19.65            1DLC1454                    ATOM  1331                                                                              O  PHE 228                                                                               45.418                                                                             66.387                                                                             44.361                                                                             1.00                                                                              20.81            1DLC1455                    ATOM  1332                                                                              CB PHE 228                                                                               48.102                                                                             67.523                                                                             42.832                                                                             1.00                                                                              15.98            1DLC1456                    ATOM  1333                                                                              CG PHE 228                                                                               48.416                                                                             68.035                                                                             41.445                                                                             1.00                                                                              14.18            1DLC1457                    ATOM  1334                                                                              CD1                                                                               PHE 228                                                                               47.425                                                                             68.103                                                                             40.466                                                                             1.00                                                                              9.27             1DLC1458                    ATOM  1335                                                                              CD2                                                                               PHE 228                                                                               49.726                                                                             68.404                                                                             41.108                                                                             1.00                                                                              12.83            1DLC1459                    ATOM  1336                                                                              CE1                                                                               PHE 228                                                                               47.729                                                                             68.523                                                                             39.178                                                                             1.00                                                                              8.69             1DLC1460                    ATOM  1337                                                                              CE2                                                                               PHE 228                                                                               50.047                                                                             68.829                                                                             39.816                                                                             1.00                                                                              9.25             1DLC1461                    ATOM  1338                                                                              CZ PHE 228                                                                               49.049                                                                             68.887                                                                             38.849                                                                             1.00                                                                              13.45            1DLC1462                    ATOM  1339                                                                              N  TYR 229                                                                               46.919                                                                             67.297                                                                             45.757                                                                             1.00                                                                              17.04            1DLC1463                    ATOM  1340                                                                              CA TYR 229                                                                               46.503                                                                             66.451                                                                             46.867                                                                             1.00                                                                              17.31            1DLC1464                    ATOM  1341                                                                              C  TYR 229                                                                               45.048                                                                             66.729                                                                             47.261                                                                             1.00                                                                              20.11            1DLC1465                    ATOM  1342                                                                              O  TYR 229                                                                               44.249                                                                             65.798                                                                             47.369                                                                             1.00                                                                              23.73            1DLC1466                    ATOM  1343                                                                              CB TYR 229                                                                               47.426                                                                             66.625                                                                             48.072                                                                             1.00                                                                              13.52            1DLC1467                    ATOM  1344                                                                              CG TYR 229                                                                               47.095                                                                             65.691                                                                             49.217                                                                             1.00                                                                              10.64            1DLC1468                    ATOM  1345                                                                              CD1                                                                               TYR 229                                                                               47.277                                                                             64.319                                                                             49.094                                                                             1.00                                                                              9.77             1DLC1469                    ATOM  1346                                                                              CD2                                                                               TYR 229                                                                               46.575                                                                             66.178                                                                             50.412                                                                             1.00                                                                              10.19            1DLC1470                    ATOM  1347                                                                              CE1                                                                               TYR 229                                                                               46.947                                                                             63.455                                                                             50.131                                                                             1.00                                                                              9.80             1DLC1471                    ATOM  1348                                                                              CE2                                                                               TYR 229                                                                               46.242                                                                             65.320                                                                             51.453                                                                             1.00                                                                              12.10            1DLC1472                    ATOM  1349                                                                              CZ TYR 229                                                                               46.431                                                                             63.961                                                                             51.304                                                                             1.00                                                                              11.99            1DLC1473                    ATOM  1350                                                                              OH TYR 229                                                                               46.106                                                                             63.107                                                                             52.330                                                                             1.00                                                                              16.85            1DLC1474                    ATOM  1351                                                                              N  LYS 230                                                                               44.693                                                                             67.998                                                                             47.462                                                                             1.00                                                                              19.47            1DLC1475                    ATOM  1352                                                                              CA LYS 230                                                                               43.313                                                                             68.326                                                                             47.818                                                                             1.00                                                                              19.61            1DLC1476                    ATOM  1353                                                                              C  LYS 230                                                                               42.357                                                                             67.868                                                                             46.723                                                                             1.00                                                                              19.13            1DLC1477                    ATOM  1354                                                                              O  LYS 230                                                                               41.259                                                                             67.382                                                                             47.008                                                                             1.00                                                                              20.93            1DLC1478                    ATOM  1355                                                                              CB LYS 230                                                                               43.137                                                                             69.812                                                                             48.083                                                                             1.00                                                                              17.36            1DLC1479                    ATOM  1356                                                                              CG LYS 230                                                                               43.786                                                                             70.262                                                                             49.367                                                                             1.00                                                                              22.08            1DLC1480                    ATOM  1357                                                                              CD LYS 230                                                                               43.346                                                                             71.657                                                                             49.735                                                                             1.00                                                                              22.71            1DLC1481                    ATOM  1358                                                                              CE LYS 230                                                                               41.854                                                                             71.690                                                                             49.992                                                                             1.00                                                                              22.53            1DLC1482                    ATOM  1359                                                                              NZ LYS 230                                                                               41.408                                                                             73.051                                                                             50.364                                                                             1.00                                                                              25.70            1DLC1483                    ATOM  1360                                                                              N  ARG 231                                                                               42.794                                                                             67.975                                                                             45.474                                                                             1.00                                                                              15.74            1DLC1484                    ATOM  1361                                                                              CA ARG 231                                                                               41.972                                                                             67.527                                                                             44.366                                                                             1.00                                                                              16.22            1DLC1485                    ATOM  1362                                                                              C  ARG 231                                                                               41.786                                                                             66.011                                                                             44.455                                                                             1.00                                                                              17.99            1DLC1486                    ATOM  1363                                                                              O  ARG 231                                                                               40.698                                                                             65.508                                                                             44.202                                                                             1.00                                                                              20.26            1DLC1487                    ATOM  1364                                                                              CB ARG 231                                                                               42.615                                                                             67.904                                                                             43.033                                                                             1.00                                                                              20.80            1DLC1488                    ATOM  1365                                                                              CG ARG 231                                                                               41.890                                                                             67.346                                                                             41.811                                                                             1.00                                                                              20.81            1DLC1489                    ATOM  1366                                                                              CD ARG 231                                                                               42.356                                                                             68.028                                                                             40.534                                                                             1.00                                                                              25.62            1DLC1490                    ATOM  1367                                                                              NE ARG 231                                                                               42.219                                                                             69.481                                                                             40.616                                                                             1.00                                                                              25.19            1DLC1491                    ATOM  1368                                                                              CZ ARG 231                                                                               43.158                                                                             70.346                                                                             40.247                                                                             1.00                                                                              24.34            1DLC1492                    ATOM  1369                                                                              NH1                                                                               ARG 231                                                                               44.314                                                                             69.913                                                                             39.760                                                                             1.00                                                                              25.84            1DLC1493                    ATOM  1370                                                                              NH2                                                                               ARG 231                                                                               42.947                                                                             71.648                                                                             40.390                                                                             1.00                                                                              23.15            1DLC1494                    ATOM  1371                                                                              N  GLN 232                                                                               42.838                                                                             65.293                                                                             44.852                                                                             1.00                                                                              16.37            1DLC1495                    ATOM  1372                                                                              CA GLN 232                                                                               42.779                                                                             63.840                                                                             44.982                                                                             1.00                                                                              14.65            1DLC1496                    ATOM  1373                                                                              C  GLN 232                                                                               41.786                                                                             63.422                                                                             46.068                                                                             1.00                                                                              16.33            1DLC1497                    ATOM  1374                                                                              O  GLN 232                                                                               41.011                                                                             62.491                                                                             45.883                                                                             1.00                                                                              19.48            1DLC1498                    ATOM  1375                                                                              CB GLN 232                                                                               44.160                                                                             63.255                                                                             45.289                                                                             1.00                                                                              13.62            1DLC1499                    ATOM  1376                                                                              CG GLN 232                                                                               44.250                                                                             61.761                                                                             45.006                                                                             1.00                                                                              16.45            1DLC1500                    ATOM  1377                                                                              CD GLN 232                                                                               45.507                                                                             61.102                                                                             45.540                                                                             1.00                                                                              18.66            1DLC1501                    ATOM  1378                                                                              OE1                                                                               GLN 232                                                                               45.465                                                                             59.968                                                                             46.006                                                                             1.00                                                                              21.82            1DLC1502                    ATOM  1379                                                                              NE2                                                                               GLN 232                                                                               46.631                                                                             61.797                                                                             45.468                                                                             1.00                                                                              17.44            1DLC1503                    ATOM  1380                                                                              N  LEU 233                                                                               41.812                                                                             64.114                                                                             47.201                                                                             1.00                                                                              13.18            1DLC1504                    ATOM  1381                                                                              CA LEU 233                                                                               40.888                                                                             63.820                                                                             48.289                                                                             1.00                                                                              15.87            1DLC1505                    ATOM  1382                                                                              C  LEU 233                                                                               39.427                                                                             64.066                                                                             47.879                                                                             1.00                                                                              17.22            1DLC1506                    ATOM  1383                                                                              O  LEU 233                                                                               38.549                                                                             63.248                                                                             48.157                                                                             1.00                                                                              22.21            1DLC1507                    ATOM  1384                                                                              CB LEU 233                                                                               41.209                                                                             64.679                                                                             49.507                                                                             1.00                                                                              14.55            1DLC1508                    ATOM  1385                                                                              CG LEU 233                                                                               42.582                                                                             64.520                                                                             50.148                                                                             1.00                                                                              18.77            1DLC1509                    ATOM  1386                                                                              CD1                                                                               LEU 233                                                                               42.837                                                                             65.712                                                                             51.054                                                                             1.00                                                                              21.30            1DLC1510                    ATOM  1387                                                                              CD2                                                                               LEU 233                                                                               42.664                                                                             63.219                                                                             50.918                                                                             1.00                                                                              17.59            1DLC1511                    ATOM  1388                                                                              N  LYS 234                                                                               39.166                                                                             65.191                                                                             47.222                                                                             1.00                                                                              16.53            1DLC1512                    ATOM  1389                                                                              CA LYS 234                                                                               37.811                                                                             65.504                                                                             46.802                                                                             1.00                                                                              17.73            1DLC1513                    ATOM  1390                                                                              C  LYS 234                                                                               37.280                                                                             64.450                                                                             45.831                                                                             1.00                                                                              18.98            1DLC1514                    ATOM  1391                                                                              O  LYS 234                                                                               36.177                                                                             63.925                                                                             46.003                                                                             1.00                                                                              20.56            1DLC1515                    ATOM  1392                                                                              CB LYS 234                                                                               37.748                                                                             66.882                                                                             46.145                                                                             1.00                                                                              19.54            1DLC1516                    ATOM  1393                                                                              CG LYS 234                                                                               36.316                                                                             67.360                                                                             45.891                                                                             1.00                                                                              30.78            1DLC1517                    ATOM  1394                                                                              CD LYS 234                                                                               36.236                                                                             68.364                                                                             44.747                                                                             1.00                                                                              39.43            1DLC1518                    ATOM  1395                                                                              CE LYS 234                                                                               36.703                                                                             67.727                                                                             43.433                                                                             1.00                                                                              48.46            1DLC1519                    ATOM  1396                                                                              NZ LYS 234                                                                               36.739                                                                             68.660                                                                             42.257                                                                             1.00                                                                              52.24            1DLC1520                    ATOM  1397                                                                              N  LEU 235                                                                               38.080                                                                             64.119                                                                             44.825                                                                             1.00                                                                              19.47            1DLC1521                    ATOM  1398                                                                              CA LEU 235                                                                               37.677                                                                             63.142                                                                             43.826                                                                             1.00                                                                              16.47            1DLC1522                    ATOM  1399                                                                              C  LEU 235                                                                               37.536                                                                             61.714                                                                             44.346                                                                             1.00                                                                              16.10            1DLC1523                    ATOM  1400                                                                              O  LEU 235                                                                               36.694                                                                             60.961                                                                             43.862                                                                             1.00                                                                              19.12            1DLC1524                    ATOM  1401                                                                              CB LEU 235                                                                               38.593                                                                             63.224                                                                             42.604                                                                             1.00                                                                              17.24            1DLC1525                    ATOM  1402                                                                              CG LEU 235                                                                               38.518                                                                             64.594                                                                             41.903                                                                             1.00                                                                              18.14            1DLC1526                    ATOM  1403                                                                              CD1                                                                               LEU 235                                                                               39.500                                                                             64.684                                                                             40.746                                                                             1.00                                                                              17.32            1DLC1527                    ATOM  1404                                                                              CD2                                                                               LEU 235                                                                               37.100                                                                             64.843                                                                             41.415                                                                             1.00                                                                              19.19            1DLC1528                    ATOM  1405                                                                              N  THR 236                                                                               38.324                                                                             61.337                                                                             45.347                                                                             1.00                                                                              15.47            1DLC1529                    ATOM  1406                                                                              CA THR 236                                                                               38.200                                                                             59.988                                                                             45.915                                                                             1.00                                                                              16.87            1DLC1530                    ATOM  1407                                                                              C  THR 236                                                                               36.816                                                                             59.809                                                                             46.545                                                                             1.00                                                                              16.35            1DLC1531                    ATOM  1408                                                                              O  THR 236                                                                               36.196                                                                             58.763                                                                             46.418                                                                             1.00                                                                              16.83            1DLC1532                    ATOM  1409                                                                              CB THR 236                                                                               39.284                                                                             59.705                                                                             46.966                                                                             1.00                                                                              15.64            1DLC1533                    ATOM  1410                                                                              OG1                                                                               THR 236                                                                               40.562                                                                             59.726                                                                             46.323                                                                             1.00                                                                              21.58            1DLC1534                    ATOM  1411                                                                              CG2                                                                               THR 236                                                                               39.073                                                                             58.337                                                                             47.618                                                                             1.00                                                                              11.02            1DLC1535                    ATOM  1412                                                                              N  GLN 237                                                                               36.333                                                                             60.845                                                                             47.216                                                                             1.00                                                                              16.17            1DLC1536                    ATOM  1413                                                                              CA GLN 237                                                                               35.014                                                                             60.821                                                                             47.830                                                                             1.00                                                                              15.51            1DLC1537                    ATOM  1414                                                                              C  GLN 237                                                                               33.905                                                                             60.798                                                                             46.748                                                                             1.00                                                                              17.21            1DLC1538                    ATOM  1415                                                                              O  GLN 237                                                                               33.015                                                                             59.944                                                                             46.773                                                                             1.00                                                                              16.26            1DLC1539                    ATOM  1416                                                                              CB GLN 237                                                                               34.881                                                                             62.037                                                                             48.751                                                                             1.00                                                                              16.03            1DLC1540                    ATOM  1417                                                                              CG GLN 237                                                                               33.537                                                                             62.217                                                                             49.423                                                                             1.00                                                                              21.22            1DLC1541                    ATOM  1418                                                                              CD GLN 237                                                                               32.598                                                                             63.054                                                                             48.596                                                                             1.00                                                                              25.16            1DLC1542                    ATOM  1419                                                                              OE1                                                                               GLN 237                                                                               32.760                                                                             64.265                                                                             48.486                                                                             1.00                                                                              27.94            1DLC1543                    ATOM  1420                                                                              NE2                                                                               GLN 237                                                                               31.633                                                                             62.411                                                                             47.969                                                                             1.00                                                                              27.25            1DLC1544                    ATOM  1421                                                                              N  GLU 238                                                                               33.998                                                                             61.704                                                                             45.776                                                                             1.00                                                                              18.54            1DLC1545                    ATOM  1422                                                                              CA GLU 238                                                                               33.016                                                                             61.807                                                                             44.693                                                                             1.00                                                                              19.10            1DLC1546                    ATOM  1423                                                                              C  GLU 238                                                                               32.901                                                                             60.561                                                                             43.828                                                                             1.00                                                                              19.60            1DLC1547                    ATOM  1424                                                                              O  GLU 238                                                                               31.802                                                                             60.063                                                                             43.584                                                                             1.00                                                                              22.82            1DLC1548                    ATOM  1425                                                                              CB GLU 238                                                                               33.326                                                                             63.001                                                                             43.789                                                                             1.00                                                                              20.79            1DLC1549                    ATOM  1426                                                                              CG GLU 238                                                                               33.126                                                                             64.348                                                                             44.446                                                                             1.00                                                                              32.20            1DLC1550                    ATOM  1427                                                                              CD GLU 238                                                                               33.403                                                                             65.518                                                                             43.513                                                                             1.00                                                                              38.00            1DLC1551                    ATOM  1428                                                                              OE1                                                                               GLU 238                                                                               33.582                                                                             65.314                                                                             42.283                                                                             1.00                                                                              38.36            1DLC1552                    ATOM  1429                                                                              OE2                                                                               GLU 238                                                                               33.434                                                                             66.657                                                                             44.028                                                                             1.00                                                                              45.77            1DLC1553                    ATOM  1430                                                                              N  TYR 239                                                                               34.032                                                                             60.082                                                                             43.328                                                                             1.00                                                                              17.99            1DLC1554                    ATOM  1431                                                                              CA TYR 239                                                                               34.041                                                                             58.899                                                                             42.481                                                                             1.00                                                                              16.20            1DLC1555                    ATOM  1432                                                                              C  TYR 239                                                                               33.495                                                                             57.670                                                                             43.212                                                                             1.00                                                                              15.23            1DLC1556                    ATOM  1433                                                                              O  TYR 239                                                                               32.726                                                                             56.900                                                                             42.652                                                                             1.00                                                                              15.80            1DLC1557                    ATOM  1434                                                                              CB TYR 239                                                                               35.455                                                                             58.646                                                                             41.965                                                                             1.00                                                                              18.91            1DLC1558                    ATOM  1435                                                                              CG TYR 239                                                                               35.987                                                                             59.715                                                                             41.022                                                                             1.00                                                                              15.91            1DLC1559                    ATOM  1436                                                                              CD1                                                                               TYR 239                                                                               35.124                                                                             60.541                                                                             40.304                                                                             1.00                                                                              14.94            1DLC1560                    ATOM  1437                                                                              CD2                                                                               TYR 239                                                                               37.357                                                                             59.844                                                                             40.794                                                                             1.00                                                                              18.81            1DLC1561                    ATOM  1438                                                                              CE1                                                                               TYR 239                                                                               35.612                                                                             61.455                                                                             39.375                                                                             1.00                                                                              12.13            1DLC1562                    ATOM  1439                                                                              CE2                                                                               TYR 239                                                                               37.853                                                                             60.756                                                                             39.863                                                                             1.00                                                                              15.85            1DLC1563                    ATOM  1440                                                                              CZ TYR 239                                                                               36.978                                                                             61.552                                                                             39.155                                                                             1.00                                                                              13.69            1DLC1564                    ATOM  1441                                                                              OH TYR 239                                                                               37.468                                                                             62.392                                                                             38.181                                                                             1.00                                                                              16.58            1DLC1565                    ATOM  1442                                                                              N  THR 240                                                                               33.849                                                                             57.529                                                                             44.486                                                                             1.00                                                                              17.13            1DLC1566                    ATOM  1443                                                                              CA THR 240                                                                               33.385                                                                             56.406                                                                             45.296                                                                             1.00                                                                              14.37            1DLC1567                    ATOM  1444                                                                              C  THR 240                                                                               31.878                                                                             56.494                                                                             45.457                                                                             1.00                                                                              16.34            1DLC1568                    ATOM  1445                                                                              O  THR 240                                                                               31.155                                                                             55.554                                                                             45.126                                                                             1.00                                                                              17.60            1DLC1569                    ATOM  1446                                                                              CB THR 240                                                                               34.041                                                                             56.398                                                                             46.701                                                                             1.00                                                                              17.40            1DLC1570                    ATOM  1447                                                                              OG1                                                                               THR 240                                                                               35.450                                                                             56.166                                                                             46.573                                                                             1.00                                                                              22.45            1DLC1571                    ATOM  1448                                                                              CG2                                                                               THR 240                                                                               33.436                                                                             55.308                                                                             47.585                                                                             1.00                                                                              14.03            1DLC1572                    ATOM  1449                                                                              N  ASP 241                                                                               31.406                                                                             57.637                                                                             45.946                                                                             1.00                                                                              16.35            1DLC1573                    ATOM  1450                                                                              CA ASP 241                                                                               29.977                                                                             57.844                                                                             46.145                                                                             1.00                                                                              13.45            1DLC1574                    ATOM  1451                                                                              C  ASP 241                                                                               29.170                                                                             57.692                                                                             44.863                                                                             1.00                                                                              15.38            1DLC1575                    ATOM  1452                                                                              O  ASP 241                                                                               28.119                                                                             57.051                                                                             44.862                                                                             1.00                                                                              21.27            1DLC1576                    ATOM  1453                                                                              CB ASP 241                                                                               29.709                                                                             59.192                                                                             46.813                                                                             1.00                                                                              12.03            1DLC1577                    ATOM  1454                                                                              CG ASP 241                                                                               30.062                                                                             59.192                                                                             48.290                                                                             1.00                                                                              10.13            1DLC1578                    ATOM  1455                                                                              OD1                                                                               ASP 241                                                                               30.272                                                                             58.107                                                                             48.864                                                                             1.00                                                                              15.38            1DLC1579                    ATOM  1456                                                                              OD2                                                                               ASP 241                                                                               30.122                                                                             60.277                                                                             48.890                                                                             1.00                                                                              14.27            1DLC1580                    ATOM  1457                                                                              N  HIS 242                                                                               29.692                                                                             58.205                                                                             43.757                                                                             1.00                                                                              14.94            1DLC1581                    ATOM  1458                                                                              CA HIS 242                                                                               28.996                                                                             58.082                                                                             42.487                                                                             1.00                                                                              15.39            1DLC1582                    ATOM  1459                                                                              C  HIS 242                                                                               28.766                                                                             56.608                                                                             42.139                                                                             1.00                                                                              17.79            1DLC1583                    ATOM  1460                                                                              O  HIS 242                                                                               27.659                                                                             56.214                                                                             41.793                                                                             1.00                                                                              22.62            1DLC1584                    ATOM  1461                                                                              CB HIS 242                                                                               29.781                                                                             58.772                                                                             41.360                                                                             1.00                                                                              15.91            1DLC1585                    ATOM  1462                                                                              CG HIS 242                                                                               29.170                                                                             58.600                                                                             39.997                                                                             1.00                                                                              17.44            1DLC1586                    ATOM  1463                                                                              ND1                                                                               HIS 242                                                                               28.285                                                                             59.508                                                                             39.454                                                                             1.00                                                                              20.18            1DLC1587                    ATOM  1464                                                                              CD2                                                                               HIS 242                                                                               29.320                                                                             57.623                                                                             39.069                                                                             1.00                                                                              17.90            1DLC1588                    ATOM  1465                                                                              CE1                                                                               HIS 242                                                                               27.916                                                                             59.100                                                                             38.251                                                                             1.00                                                                              16.84            1DLC1589                    ATOM  1466                                                                              NE2                                                                               HIS 242                                                                               28.530                                                                             57.958                                                                             37.995                                                                             1.00                                                                              20.33            1DLC1590                    ATOM  1467                                                                              N  CYS 243                                                                               29.804                                                                             55.793                                                                             42.262                                                                             1.00                                                                              17.39            1DLC1591                    ATOM  1468                                                                              CA CYS 243                                                                               29.694                                                                             54.377                                                                             41.924                                                                             1.00                                                                              17.86            1DLC1592                    ATOM  1469                                                                              C  CYS 243                                                                               28.721                                                                             53.588                                                                             42.776                                                                             1.00                                                                              17.12            1DLC1593                    ATOM  1470                                                                              O  CYS 243                                                                               27.939                                                                             52.800                                                                             42.251                                                                             1.00                                                                              21.15            1DLC1594                    ATOM  1471                                                                              CB CYS 243                                                                               31.071                                                                             53.712                                                                             41.923                                                                             1.00                                                                              15.41            1DLC1595                    ATOM  1472                                                                              SG CYS 243                                                                               32.126                                                                             54.356                                                                             40.620                                                                             1.00                                                                              18.63            1DLC1596                    ATOM  1473                                                                              N  VAL 244                                                                               28.742                                                                             53.812                                                                             44.083                                                                             1.00                                                                              17.77            1DLC1597                    ATOM  1474                                                                              CA VAL 244                                                                               27.829                                                                             53.099                                                                             44.961                                                                             1.00                                                                              17.07            1DLC1598                    ATOM  1475                                                                              C  VAL 244                                                                               26.368                                                                             53.507                                                                             44.693                                                                             1.00                                                                              17.91            1DLC1599                    ATOM  1476                                                                              O  VAL 244                                                                               25.492                                                                             52.658                                                                             44.569                                                                             1.00                                                                              17.98            1DLC1600                    ATOM  1477                                                                              CB VAL 244                                                                               28.185                                                                             53.318                                                                             46.434                                                                             1.00                                                                              16.68            1DLC1601                    ATOM  1478                                                                              CG1                                                                               VAL 244                                                                               27.179                                                                             52.611                                                                             47.319                                                                             1.00                                                                              15.45            1DLC1602                    ATOM  1479                                                                              CG2                                                                               VAL 244                                                                               29.582                                                                             52.804                                                                             46.711                                                                             1.00                                                                              11.35            1DLC1603                    ATOM  1480                                                                              N  LYS 245                                                                               26.129                                                                             54.805                                                                             44.551                                                                             1.00                                                                              19.29            1DLC1604                    ATOM  1481                                                                              CA LYS 245                                                                               24.788                                                                             55.326                                                                             44.282                                                                             1.00                                                                              21.04            1DLC1605                    ATOM  1482                                                                              C  LYS 245                                                                               24.142                                                                             54.667                                                                             43.056                                                                             1.00                                                                              23.00            1DLC1606                    ATOM  1483                                                                              O  LYS 245                                                                               23.031                                                                             54.139                                                                             43.137                                                                             1.00                                                                              24.89            1DLC1607                    ATOM  1484                                                                              CB LYS 245                                                                               24.855                                                                             56.837                                                                             44.073                                                                             1.00                                                                              21.68            1DLC1608                    ATOM  1485                                                                              CG LYS 245                                                                               23.552                                                                             57.472                                                                             43.640                                                                             1.00                                                                              22.74            1DLC1609                    ATOM  1486                                                                              CD LYS 245                                                                               23.779                                                                             58.929                                                                             43.268                                                                             1.00                                                                              30.91            1DLC1610                    ATOM  1487                                                                              CE LYS 245                                                                               22.469                                                                             59.687                                                                             43.068                                                                             1.00                                                                              34.31            1DLC1611                    ATOM  1488                                                                              NZ LYS 245                                                                               21.742                                                                             59.275                                                                             41.844                                                                             1.00                                                                              37.08            1DLC1612                    ATOM  1489                                                                              N  TRP 246                                                                               24.848                                                                             54.682                                                                             41.930                                                                             1.00                                                                              20.59            1DLC1613                    ATOM  1490                                                                              CA TRP 246                                                                               24.332                                                                             54.088                                                                             40.701                                                                             1.00                                                                              19.32            1DLC1614                    ATOM  1491                                                                              C  TRP 246                                                                               24.386                                                                             52.568                                                                             40.685                                                                             1.00                                                                              21.56            1DLC1615                    ATOM  1492                                                                              O  TRP 246                                                                               23.604                                                                             51.918                                                                             39.983                                                                             1.00                                                                              23.26            1DLC1616                    ATOM  1493                                                                              CB TRP 246                                                                               25.026                                                                             54.695                                                                             39.489                                                                             1.00                                                                              16.97            1DLC1617                    ATOM  1494                                                                              CG TRP 246                                                                               24.705                                                                             56.132                                                                             39.400                                                                             1.00                                                                              20.83            1DLC1618                    ATOM  1495                                                                              CD1                                                                               TRP 246                                                                               25.528                                                                             57.179                                                                             39.697                                                                             1.00                                                                              22.17            1DLC1619                    ATOM  1496                                                                              CD2                                                                               TRP 246                                                                               23.427                                                                             56.697                                                                             39.096                                                                             1.00                                                                              21.29            1DLC1620                    ATOM  1497                                                                              NE1                                                                               TRP 246                                                                               24.837                                                                             58.361                                                                             39.609                                                                             1.00                                                                              24.09            1DLC1621                    ATOM  1498                                                                              CE2                                                                               TRP 246                                                                               23.546                                                                             58.097                                                                             39.239                                                                             1.00                                                                              23.54            1DLC1622                    ATOM  1499                                                                              CE3                                                                               TRP 246                                                                               22.191                                                                             56.157                                                                             38.722                                                                             1.00                                                                              20.29            1DLC1623                    ATOM  1500                                                                              CZ2                                                                               TRP 246                                                                               22.473                                                                             58.966                                                                             39.021                                                                             1.00                                                                              23.70            1DLC1624                    ATOM  1501                                                                              CZ3                                                                               TRP 246                                                                               21.127                                                                             57.017                                                                             38.507                                                                             1.00                                                                              22.34            1DLC1625                    ATOM  1502                                                                              CH2                                                                               TRP 246                                                                               21.274                                                                             58.410                                                                             38.657                                                                             1.00                                                                              23.62            1DLC1626                    ATOM  1503                                                                              N  TYR 247                                                                               25.304                                                                             51.997                                                                             41.460                                                                             1.00                                                                              20.03            1DLC1627                    ATOM  1504                                                                              CA TYR 247                                                                               25.385                                                                             50.549                                                                             41.558                                                                             1.00                                                                              20.17            1DLC1628                    ATOM  1505                                                                              C  TYR 247                                                                               24.034                                                                             50.088                                                                             42.133                                                                             1.00                                                                              19.37            1DLC1629                    ATOM  1506                                                                              O  TYR 247                                                                               23.360                                                                             49.230                                                                             41.561                                                                             1.00                                                                              19.35            1DLC1630                    ATOM  1507                                                                              CB TYR 247                                                                               26.528                                                                             50.121                                                                             42.494                                                                             1.00                                                                              17.68            1DLC1631                    ATOM  1508                                                                              CG TYR 247                                                                               26.392                                                                             48.689                                                                             42.957                                                                             1.00                                                                              13.41            1DLC1632                    ATOM  1509                                                                              CD1                                                                               TYR 247                                                                               26.579                                                                             47.633                                                                             42.067                                                                             1.00                                                                              14.48            1DLC1633                    ATOM  1510                                                                              CD2                                                                               TYR 247                                                                               25.966                                                                             48.398                                                                             44.247                                                                             1.00                                                                              11.29            1DLC1634                    ATOM  1511                                                                              CE1                                                                               TYR 247                                                                               26.331                                                                             46.325                                                                             42.446                                                                             1.00                                                                              14.18            1DLC1635                    ATOM  1512                                                                              CE2                                                                               TYR 247                                                                               25.714                                                                             47.096                                                                             44.637                                                                             1.00                                                                              13.99            1DLC1636                    ATOM  1513                                                                              CZ TYR 247                                                                               25.892                                                                             46.063                                                                             43.729                                                                             1.00                                                                              16.05            1DLC1637                    ATOM  1514                                                                              OH TYR 247                                                                               25.586                                                                             44.773                                                                             44.087                                                                             1.00                                                                              19.99            1DLC1638                    ATOM  1515                                                                              N  ASN 248                                                                               23.634                                                                             50.709                                                                             43.243                                                                             1.00                                                                              16.91            1DLC1639                    ATOM  1516                                                                              CA ASN 248                                                                               22.373                                                                             50.393                                                                             43.905                                                                             1.00                                                                              19.32            1DLC1640                    ATOM  1517                                                                              C  ASN 248                                                                               21.147                                                                             50.687                                                                             43.031                                                                             1.00                                                                              19.33            1DLC1641                    ATOM  1518                                                                              O  ASN 248                                                                               20.169                                                                             49.939                                                                             43.050                                                                             1.00                                                                              18.74            1DLC1642                    ATOM  1519                                                                              CB ASN 248                                                                               22.276                                                                             51.116                                                                             45.250                                                                             1.00                                                                              18.47            1DLC1643                    ATOM  1520                                                                              CG ASN 248                                                                               23.141                                                                             50.471                                                                             46.315                                                                             1.00                                                                              23.56            1DLC1644                    ATOM  1521                                                                              OD1                                                                               ASN 248                                                                               23.184                                                                             49.249                                                                             46.438                                                                             1.00                                                                              28.32            1DLC1645                    ATOM  1522                                                                              ND2                                                                               ASN 248                                                                               23.844                                                                             51.284                                                                             47.081                                                                             1.00                                                                              24.45            1DLC1646                    ATOM  1523                                                                              N  VAL 249                                                                               21.207                                                                             51.763                                                                             42.253                                                                             1.00                                                                              17.79            1DLC1647                    ATOM  1524                                                                              CA VAL 249                                                                               20.105                                                                             52.103                                                                             41.366                                                                             1.00                                                                              16.98            1DLC1648                    ATOM  1525                                                                              C  VAL 249                                                                               19.883                                                                             50.921                                                                             40.422                                                                             1.00                                                                              19.97            1DLC1649                    ATOM  1526                                                                              O  VAL 249                                                                               18.763                                                                             50.425                                                                             40.284                                                                             1.00                                                                              22.20            1DLC1650                    ATOM  1527                                                                              CB VAL 249                                                                               20.403                                                                             53.384                                                                             40.550                                                                             1.00                                                                              15.18            1DLC1651                    ATOM  1528                                                                              CG1                                                                               VAL 249                                                                               19.374                                                                             53.566                                                                             39.445                                                                             1.00                                                                              8.38             1DLC1652                    ATOM  1529                                                                              CG2                                                                               VAL 249                                                                               20.399                                                                             54.596                                                                             41.467                                                                             1.00                                                                              12.81            1DLC1653                    ATOM  1530                                                                              N  GLY 250                                                                               20.970                                                                             50.431                                                                             39.834                                                                             1.00                                                                              19.71            1DLC1654                    ATOM  1531                                                                              CA GLY 250                                                                               20.879                                                                             49.304                                                                             38.924                                                                             1.00                                                                              20.85            1DLC1655                    ATOM  1532                                                                              C  GLY 250                                                                               20.409                                                                             48.035                                                                             39.609                                                                             1.00                                                                              22.20            1DLC1656                    ATOM  1533                                                                              O  GLY 250                                                                               19.558                                                                             47.316                                                                             39.089                                                                             1.00                                                                              26.29            1DLC1657                    ATOM  1534                                                                              N  LEU 251                                                                               20.935                                                                             47.772                                                                             40.797                                                                             1.00                                                                              20.95            1DLC1658                    ATOM  1535                                                                              CA LEU 251                                                                               20.554                                                                             46.594                                                                             41.563                                                                             1.00                                                                              20.76            1DLC1659                    ATOM  1536                                                                              C  LEU 251                                                                               19.031                                                                             46.532                                                                             41.792                                                                             1.00                                                                              22.33            1DLC1660                    ATOM  1537                                                                              O  LEU 251                                                                               18.386                                                                             45.516                                                                             41.502                                                                             1.00                                                                              21.83            1DLC1661                    ATOM  1538                                                                              CB LEU 251                                                                               21.299                                                                             46.597                                                                             42.900                                                                             1.00                                                                              17.68            1DLC1662                    ATOM  1539                                                                              CG LEU 251                                                                               21.274                                                                             45.306                                                                             43.716                                                                             1.00                                                                              19.56            1DLC1663                    ATOM  1540                                                                              CD1                                                                               LEU 251                                                                               21.908                                                                             44.160                                                                             42.937                                                                             1.00                                                                              16.74            1DLC1664                    ATOM  1541                                                                              CD2                                                                               LEU 251                                                                               22.002                                                                             45.537                                                                             45.009                                                                             1.00                                                                              16.93            1DLC1665                    ATOM  1542                                                                              N  ASP 252                                                                               18.463                                                                             47.629                                                                             42.287                                                                             1.00                                                                              25.34            1DLC1666                    ATOM  1543                                                                              CA ASP 252                                                                               17.023                                                                             47.721                                                                             42.548                                                                             1.00                                                                              26.45            1DLC1667                    ATOM  1544                                                                              C  ASP 252                                                                               16.172                                                                             47.589                                                                             41.288                                                                             1.00                                                                              29.16            1DLC1668                    ATOM  1545                                                                              O  ASP 252                                                                               15.089                                                                             47.015                                                                             41.322                                                                             1.00                                                                              32.76            1DLC1669                    ATOM  1546                                                                              CB ASP 252                                                                               16.684                                                                             49.029                                                                             43.257                                                                             1.00                                                                              28.64            1DLC1670                    ATOM  1547                                                                              CG ASP 252                                                                               17.192                                                                             49.071                                                                             44.686                                                                             1.00                                                                              35.67            1DLC1671                    ATOM  1548                                                                              OD1                                                                               ASP 252                                                                               17.305                                                                             48.002                                                                             45.331                                                                             1.00                                                                              40.98            1DLC1672                    ATOM  1549                                                                              OD2                                                                               ASP 252                                                                               17.476                                                                             50.184                                                                             45.170                                                                             1.00                                                                              42.32            1DLC1673                    ATOM  1550                                                                              N  LYS 253                                                                               16.673                                                                             48.100                                                                             40.173                                                                             1.00                                                                              26.89            1DLC1674                    ATOM  1551                                                                              CA LYS 253                                                                               15.953                                                                             48.009                                                                             38.916                                                                             1.00                                                                              27.76            1DLC1675                    ATOM  1552                                                                              C  LYS 253                                                                               15.801                                                                             46.549                                                                             38.449                                                                             1.00                                                                              27.94            1DLC1676                    ATOM  1553                                                                              O  LYS 253                                                                               14.893                                                                             46.226                                                                             37.692                                                                             1.00                                                                              33.46            1DLC1677                    ATOM  1554                                                                              CB LYS 253                                                                               16.664                                                                             48.854                                                                             37.854                                                                             1.00                                                                              31.20            1DLC1678                    ATOM  1555                                                                              CG LYS 253                                                                               15.927                                                                             48.957                                                                             36.523                                                                             1.00                                                                              41.11            1DLC1679                    ATOM  1556                                                                              CD LYS 253                                                                               16.574                                                                             49.982                                                                             35.592                                                                             1.00                                                                              49.37            1DLC1680                    ATOM  1557                                                                              CE LYS 253                                                                               16.569                                                                             51.381                                                                             36.206                                                                             1.00                                                                              55.35            1DLC1681                    ATOM  1558                                                                              NZ LYS 253                                                                               17.234                                                                             52.399                                                                             35.335                                                                             1.00                                                                              58.91            1DLC1682                    ATOM  1559                                                                              N  LEU 254                                                                               16.674                                                                             45.662                                                                             38.915                                                                             1.00                                                                              26.78            1DLC1683                    ATOM  1560                                                                              CA LEU 254                                                                               16.619                                                                             44.251                                                                             38.521                                                                             1.00                                                                              24.25            1DLC1684                    ATOM  1561                                                                              C  LEU 254                                                                               15.876                                                                             43.317                                                                             39.487                                                                             1.00                                                                              25.28            1DLC1685                    ATOM  1562                                                                              O  LEU 254                                                                               15.695                                                                             42.129                                                                             39.197                                                                             1.00                                                                              24.46            1DLC1686                    ATOM  1563                                                                              CB LEU 254                                                                               18.027                                                                             43.713                                                                             38.289                                                                             1.00                                                                              22.43            1DLC1687                    ATOM  1564                                                                              CG LEU 254                                                                               18.834                                                                             44.386                                                                             37.191                                                                             1.00                                                                              21.13            1DLC1688                    ATOM  1565                                                                              CD1                                                                               LEU 254                                                                               20.199                                                                             43.748                                                                             37.114                                                                             1.00                                                                              19.25            1DLC1689                    ATOM  1566                                                                              CD2                                                                               LEU 254                                                                               18.114                                                                             44.247                                                                             35.875                                                                             1.00                                                                              18.91            1DLC1690                    ATOM  1567                                                                              N  ARG 255                                                                               15.460                                                                             43.837                                                                             40.634                                                                             1.00                                                                              24.30            1DLC1691                    ATOM  1568                                                                              CA ARG 255                                                                               14.738                                                                             43.018                                                                             41.598                                                                             1.00                                                                              26.66            1DLC1692                    ATOM  1569                                                                              C  ARG 255                                                                               13.400                                                                             42.587                                                                             41.003                                                                             1.00                                                                              26.42            1DLC1693                    ATOM  1570                                                                              O  ARG 255                                                                               12.638                                                                             43.406                                                                             40.497                                                                             1.00                                                                              28.64            1DLC1694                    ATOM  1571                                                                              CB ARG 255                                                                               14.494                                                                             43.782                                                                             42.893                                                                             1.00                                                                              27.60            1DLC1695                    ATOM  1572                                                                              CG ARG 255                                                                               15.646                                                                             44.655                                                                             43.323                                                                             1.00                                                                              35.20            1DLC1696                    ATOM  1573                                                                              CD ARG 255                                                                               15.438                                                                             45.138                                                                             44.737                                                                             1.00                                                                              35.77            1DLC1697                    ATOM  1574                                                                              NE ARG 255                                                                               15.670                                                                             44.042                                                                             45.666                                                                             1.00                                                                              40.94            1DLC1698                    ATOM  1575                                                                              CZ ARG 255                                                                               16.779                                                                             43.903                                                                             46.381                                                                             1.00                                                                              41.53            1DLC1699                    ATOM  1576                                                                              NH1                                                                               ARG 255                                                                               17.749                                                                             44.804                                                                             46.279                                                                             1.00                                                                              43.27            1DLC1700                    ATOM  1577                                                                              NH2                                                                               ARG 255                                                                               16.940                                                                             42.839                                                                             47.153                                                                             1.00                                                                              41.04            1DLC1701                    ATOM  1578                                                                              N  GLY 256                                                                               13.132                                                                             41.291                                                                             41.043                                                                             1.00                                                                              25.67            1DLC1702                    ATOM  1579                                                                              CA GLY 256                                                                               11.893                                                                             40.777                                                                             40.502                                                                             1.00                                                                              21.48            1DLC1703                    ATOM  1580                                                                              C  GLY 256                                                                               11.314                                                                             39.735                                                                             41.428                                                                             1.00                                                                              22.34            1DLC1704                    ATOM  1581                                                                              O  GLY 256                                                                               11.690                                                                             39.653                                                                             42.600                                                                             1.00                                                                              22.71            1DLC1705                    ATOM  1582                                                                              N  SER 257                                                                               10.401                                                                             38.927                                                                             40.907                                                                             1.00                                                                              22.70            1DLC1706                    ATOM  1583                                                                              CA SER 257                                                                               9.766                                                                              37.885                                                                             41.708                                                                             1.00                                                                              22.19            1DLC1707                    ATOM  1584                                                                              C  SER 257                                                                               10.123                                                                             36.504                                                                             41.191                                                                             1.00                                                                              19.96            1DLC1708                    ATOM  1585                                                                              O  SER 257                                                                               10.073                                                                             35.527                                                                             41.928                                                                             1.00                                                                              22.04            1DLC1709                    ATOM  1586                                                                              CB SER 257                                                                               8.240                                                                              38.045                                                                             41.690                                                                             1.00                                                                              22.99            1DLC1710                    ATOM  1587                                                                              OG SER 257                                                                               7.714                                                                              37.784                                                                             40.395                                                                             1.00                                                                              26.85            1DLC1711                    ATOM  1588                                                                              N  SER 258                                                                               10.488                                                                             36.427                                                                             39.920                                                                             1.00                                                                              18.79            1DLC1712                    ATOM  1589                                                                              CA SER 258                                                                               10.835                                                                             35.154                                                                             39.311                                                                             1.00                                                                              20.57            1DLC1713                    ATOM  1590                                                                              C  SER 258                                                                               12.277                                                                             34.694                                                                             39.511                                                                             1.00                                                                              22.33            1DLC1714                    ATOM  1591                                                                              O  SER 258                                                                               13.156                                                                             35.462                                                                             39.895                                                                             1.00                                                                              24.89            1DLC1715                    ATOM  1592                                                                              CB SER 258                                                                               10.544                                                                             35.191                                                                             37.809                                                                             1.00                                                                              19.52            1DLC1716                    ATOM  1593                                                                              OG SER 258                                                                               11.502                                                                             35.975                                                                             37.113                                                                             1.00                                                                              24.21            1DLC1717                    ATOM  1594                                                                              N  TYR 259                                                                               12.494                                                                             33.419                                                                             39.212                                                                             1.00                                                                              22.78            1DLC1718                    ATOM  1595                                                                              CA TYR 259                                                                               13.799                                                                             32.787                                                                             39.281                                                                             1.00                                                                              23.11            1DLC1719                    ATOM  1596                                                                              C  TYR 259                                                                               14.714                                                                             33.449                                                                             38.243                                                                             1.00                                                                              25.26            1DLC1720                    ATOM  1597                                                                              O  TYR 259                                                                               15.901                                                                             33.677                                                                             38.490                                                                             1.00                                                                              26.66            1DLC1721                    ATOM  1598                                                                              CB TYR 259                                                                               13.655                                                                             31.300                                                                             38.953                                                                             1.00                                                                              21.44            1DLC1722                    ATOM  1599                                                                              CG TYR 259                                                                               14.959                                                                             30.627                                                                             38.663                                                                             1.00                                                                              21.31            1DLC1723                    ATOM  1600                                                                              CD1                                                                               TYR 259                                                                               15.812                                                                             30.253                                                                             39.698                                                                             1.00                                                                              22.67            1DLC1724                    ATOM  1601                                                                              CD2                                                                               TYR 259                                                                               15.369                                                                             30.411                                                                             37.351                                                                             1.00                                                                              19.37            1DLC1725                    ATOM  1602                                                                              CE1                                                                               TYR 259                                                                               17.045                                                                             29.682                                                                             39.432                                                                             1.00                                                                              23.31            1DLC1726                    ATOM  1603                                                                              CE2                                                                               TYR 259                                                                               16.592                                                                             29.847                                                                             37.078                                                                             1.00                                                                              21.89            1DLC1727                    ATOM  1604                                                                              CZ TYR 259                                                                               17.430                                                                             29.485                                                                             38.121                                                                             1.00                                                                              21.29            1DLC1728                    ATOM  1605                                                                              OH TYR 259                                                                               18.655                                                                             28.932                                                                             37.850                                                                             1.00                                                                              26.88            1DLC1729                    ATOM  1606                                                                              N  GLU 260                                                                               14.154                                                                             33.732                                                                             37.073                                                                             1.00                                                                              21.58            1DLC1730                    ATOM  1607                                                                              CA GLU 260                                                                               14.900                                                                             34.374                                                                             36.001                                                                             1.00                                                                              21.56            1DLC1731                    ATOM  1608                                                                              C  GLU 260                                                                               15.315                                                                             35.785                                                                             36.432                                                                             1.00                                                                              24.51            1DLC1732                    ATOM  1609                                                                              O  GLU 260                                                                               16.393                                                                             36.262                                                                             36.075                                                                             1.00                                                                              27.27            1DLC1733                    ATOM  1610                                                                              CB GLU 260                                                                               14.064                                                                             34.432                                                                             34.723                                                                             1.00                                                                              20.53            1DLC1734                    ATOM  1611                                                                              CG GLU 260                                                                               13.701                                                                             33.066                                                                             34.117                                                                             1.00                                                                              20.94            1DLC1735                    ATOM  1612                                                                              CD GLU 260                                                                               12.625                                                                             32.287                                                                             34.887                                                                             1.00                                                                              23.83            1DLC1736                    ATOM  1613                                                                              OE1                                                                               GLU 260                                                                               11.805                                                                             32.886                                                                             35.616                                                                             1.00                                                                              27.07            1DLC1737                    ATOM  1614                                                                              OE2                                                                               GLU 260                                                                               12.593                                                                             31.051                                                                             34.743                                                                             1.00                                                                              26.90            1DLC1738                    ATOM  1615                                                                              N  SER 261                                                                               14.472                                                                             36.439                                                                             37.226                                                                             1.00                                                                              22.78            1DLC1739                    ATOM  1616                                                                              CA SER 261                                                                               14.792                                                                             37.777                                                                             37.716                                                                             1.00                                                                              24.00            1DLC1740                    ATOM  1617                                                                              C  SER 261                                                                               16.020                                                                             37.733                                                                             38.617                                                                             1.00                                                                              22.53            1DLC1741                    ATOM  1618                                                                              O  SER 261                                                                               16.941                                                                             38.550                                                                             38.490                                                                             1.00                                                                              21.49            1DLC1742                    ATOM  1619                                                                              CB SER 261                                                                               13.632                                                                             38.361                                                                             38.516                                                                             1.00                                                                              25.06            1DLC1743                    ATOM  1620                                                                              OG SER 261                                                                               12.581                                                                             38.742                                                                             37.657                                                                             1.00                                                                              40.53            1DLC1744                    ATOM  1621                                                                              N  TRP 262                                                                               16.017                                                                             36.775                                                                             39.534                                                                             1.00                                                                              17.09            1DLC1745                    ATOM  1622                                                                              CA TRP 262                                                                               17.125                                                                             36.627                                                                             40.450                                                                             1.00                                                                              19.88            1DLC1746                    ATOM  1623                                                                              C  TRP 262                                                                               18.464                                                                             36.308                                                                             39.710                                                                             1.00                                                                              18.85            1DLC1747                    ATOM  1624                                                                              O  TRP 262                                                                               19.496                                                                             36.795                                                                             40.213                                                                             1.00                                                                              22.45            1DLC1748                    ATOM  1625                                                                              CB TRP 262                                                                               16.812                                                                             35.590                                                                             41.518                                                                             1.00                                                                              16.11            1DLC1749                    ATOM  1626                                                                              CG TRP 262                                                                               17.835                                                                             35.588                                                                             42.585                                                                             1.00                                                                              17.10            1DLC1750                    ATOM  1627                                                                              CD1                                                                               TRP 262                                                                               17.807                                                                             36.307                                                                             43.745                                                                             1.00                                                                              17.25            1DLC1751                    ATOM  1628                                                                              CD2                                                                               TRP 262                                                                               19.065                                                                             34.852                                                                             42.593                                                                             1.00                                                                              17.80            1DLC1752                    ATOM  1629                                                                              NE1                                                                               TRP 262                                                                               18.943                                                                             36.061                                                                             44.476                                                                             1.00                                                                              18.81            1DLC1753                    ATOM  1630                                                                              CE2                                                                               TRP 262                                                                               19.735                                                                             35.175                                                                             43.794                                                                             1.00                                                                              18.51            1DLC1754                    ATOM  1631                                                                              CE3                                                                               TRP 262                                                                               19.668                                                                             33.951                                                                             41.699                                                                             1.00                                                                              15.16            1DLC1755                    ATOM  1632                                                                              CZ2                                                                               TRP 262                                                                               20.982                                                                             34.626                                                                             44.130                                                                             1.00                                                                              21.00            1DLC1756                    ATOM  1633                                                                              CZ3                                                                               TRP 262                                                                               20.906                                                                             33.406                                                                             42.029                                                                             1.00                                                                              15.42            1DLC1757                    ATOM  1634                                                                              CH2                                                                               TRP 262                                                                               21.550                                                                             33.745                                                                             43.235                                                                             1.00                                                                              19.20            1DLC1758                    ATOM  1635                                                                              N  VAL 263                                                                               18.458                                                                             35.502                                                                             38.709                                                                             1.00                                                                              19.89            1DLC1759                    ATOM  1636                                                                              CA VAL 263                                                                               19.708                                                                             35.174                                                                             38.014                                                                             1.00                                                                              18.35            1DLC1760                    ATOM  1637                                                                              C  VAL 263                                                                               20.311                                                                             36.456                                                                             37.453                                                                             1.00                                                                              20.15            1DLC1761                    ATOM  1638                                                                              O  VAL 263                                                                               21.505                                                                             36.7d9                                                                             37.632                                                                             1.00                                                                              24.22            1DLC1762                    ATOM  1639                                                                              CB VAL 263                                                                               19.528                                                                             34.097                                                                             36.887                                                                             1.00                                                                              18.77            1DLC1763                    ATOM  1640                                                                              CG1                                                                               VAL 263                                                                               20.859                                                                             33.850                                                                             36.151                                                                             1.00                                                                              12.43            1DLC1764                    ATOM  1641                                                                              CG2                                                                               VAL 263                                                                               19.042                                                                             32.778                                                                             37.488                                                                             1.00                                                                              14.72            1DLC1765                    ATOM  1642                                                                              N  ASN 264                                                                               19.474                                                                             37.289                                                                             36.838                                                                             1.00                                                                              19.11            1DLC1766                    ATOM  1643                                                                              CA ASN 264                                                                               19.924                                                                             38.567                                                                             36.287                                                                             1.00                                                                              19.35            1DLC1767                    ATOM  1644                                                                              C  ASN 264                                                                               20.437                                                                             39.485                                                                             37.390                                                                             1.00                                                                              19.34            1DLC1768                    ATOM  1645                                                                              O  ASN 264                                                                               21.531                                                                             40.031                                                                             37.307                                                                             1.00                                                                              21.96            1DLC1769                    ATOM  1646                                                                              CB ASN 264                                                                               18.784                                                                             39.256                                                                             35.563                                                                             1.00                                                                              24.05            1DLC1770                    ATOM  1647                                                                              CG ASN 264                                                                               18.415                                                                             38.557                                                                             34.294                                                                             1.00                                                                              30.20            1DLC1771                    ATOM  1648                                                                              OD1                                                                               ASN 264                                                                               19.233                                                                             37.850                                                                             33.710                                                                             1.00                                                                              35.20            1DLC1772                    ATOM  1649                                                                              ND2                                                                               ASN 264                                                                               17.179                                                                             38.734                                                                             33.855                                                                             1.00                                                                              30.82            1DLC1773                    ATOM  1650                                                                              N  PHE 265                                                                               19.629                                                                             39.631                                                                             38.429                                                                             1.00                                                                              19.08            1DLC1774                    ATOM  1651                                                                              CA PHE 265                                                                               19.941                                                                             40.445                                                                             39.594                                                                             1.00                                                                              16.55            1DLC1775                    ATOM  1652                                                                              C  PHE 265                                                                               21.318                                                                             40.065                                                                             40.165                                                                             1.00                                                                              17.77            1DLC1776                    ATOM  1653                                                                              O  PHE 265                                                                               22.194                                                                             40.914                                                                             40.321                                                                             1.00                                                                              19.27            1DLC1777                    ATOM  1654                                                                              CB PHE 265                                                                               18.821                                                                             40.223                                                                             40.619                                                                             1.00                                                                              12.97            1DLC1778                    ATOM  1655                                                                              CG PHE 265                                                                               19.066                                                                             40.831                                                                             41.971                                                                             1.00                                                                              10.89            1DLC1779                    ATOM  1656                                                                              CD1                                                                               PHE 265                                                                               18.677                                                                             42.137                                                                             42.241                                                                             1.00                                                                              13.68            1DLC1780                    ATOM  1657                                                                              CD2                                                                               PHE 265                                                                               19.574                                                                             40.059                                                                             43.010                                                                             1.00                                                                              9.55             1DLC1781                    ATOM  1658                                                                              CE1                                                                               PHE 265                                                                               18.780                                                                             42.663                                                                             43.530                                                                             1.00                                                                              12.86            1DLC1782                    ATOM  1659                                                                              CE2                                                                               PHE 265                                                                               19.680                                                                             40.571                                                                             44.295                                                                             1.00                                                                              10.43            1DLC1783                    ATOM  1660                                                                              CZ PHE 265                                                                               19.281                                                                             41.876                                                                             44.559                                                                             1.00                                                                              10.95            1DLC1784                    ATOM  1661                                                                              N  ASN 266                                                                               21.518                                                                             38.773                                                                             40.403                                                                             1.00                                                                              19.03            1DLC1785                    ATOM  1662                                                                              CA ASN 266                                                                               22.766                                                                             38.265                                                                             40.954                                                                             1.00                                                                              17.33            1DLC1786                    ATOM  1663                                                                              C  ASN 266                                                                               23.957                                                                             38.336                                                                             39.992                                                                             1.00                                                                              17.92            1DLC1787                    ATOM  1664                                                                              O  ASN 266                                                                               25.092                                                                             38.493                                                                             40.435                                                                             1.00                                                                              22.09            1DLC1788                    ATOM  1665                                                                              CB ASN 266                                                                               22.584                                                                             36.840                                                                             41.468                                                                             1.00                                                                              15.11            1DLC1789                    ATOM  1666                                                                              CG ASN 266                                                                               23.826                                                                             36.313                                                                             42.142                                                                             1.00                                                                              17.39            1DLC1790                    ATOM  1667                                                                              OD1                                                                               ASN 266                                                                               24.244                                                                             36.822                                                                             43.181                                                                             1.00                                                                              17.95            1DLC1791                    ATOM  1668                                                                              ND2                                                                               ASN 266                                                                               24.444                                                                             35.307                                                                             41.543                                                                             1.00                                                                              18.20            1DLC1792                    ATOM  1669                                                                              N  ARG 267                                                                               23.716                                                                             38.190                                                                             38.692                                                                             1.00                                                                              17.41            1DLC1793                    ATOM  1670                                                                              CA ARG 267                                                                               24.801                                                                             38.283                                                                             37.707                                                                             1.00                                                                              17.83            1DLC1794                    ATOM  1671                                                                              C  ARG 267                                                                               25.306                                                                             39.730                                                                             37.662                                                                             1.00                                                                              19.29            1DLC1795                    ATOM  1672                                                                              O  ARG 267                                                                               26.505                                                                             39.976                                                                             37.578                                                                             1.00                                                                              20.96            1DLC1796                    ATOM  1673                                                                              CB ARG 267                                                                               24.321                                                                             37.849                                                                             36.322                                                                             1.00                                                                              16.99            1DLC1797                    ATOM  1674                                                                              CG ARG 267                                                                               25.377                                                                             37.917                                                                             35.248                                                                             1.00                                                                              17.92            1DLC1798                    ATOM  1675                                                                              CD ARG 267                                                                               24.824                                                                             37.461                                                                             33.916                                                                             1.00                                                                              22.41            1DLC1799                    ATOM  1676                                                                              NE ARG 267                                                                               24.427                                                                             36.052                                                                             33.942                                                                             1.00                                                                              35.91            1DLC1800                    ATOM  1677                                                                              CZ ARG 267                                                                               23.190                                                                             35.599                                                                             33.727                                                                             1.00                                                                              41.26            1DLC1801                    ATOM  1678                                                                              NH1                                                                               ARG 267                                                                               22.183                                                                             36.431                                                                             33.464                                                                             1.00                                                                              42.55            1DLC1802                    ATOM  1679                                                                              NH2                                                                               ARG 267                                                                               22.959                                                                             34.293                                                                             33.767                                                                             1.00                                                                              44.18            1DLC1803                    ATOM  1680                                                                              N  TYR 268                                                                               24.378                                                                             40.681                                                                             37.735                                                                             1.00                                                                              17.33            1DLC1804                    ATOM  1681                                                                              CA TYR 268                                                                               24.711                                                                             42.098                                                                             37.748                                                                             1.00                                                                              15.33            1DLC1805                    ATOM  1682                                                                              C  TYR 268                                                                               25.505                                                                             42.391                                                                             39.018                                                                             1.00                                                                              17.40            1DLC1806                    ATOM  1683                                                                              O  TYR 268                                                                               26.557                                                                             43.032                                                                             38.976                                                                             1.00                                                                              20.28            1DLC1807                    ATOM  1684                                                                              CB TYR 268                                                                               23.432                                                                             42.932                                                                             37.739                                                                             1.00                                                                              13.81            1DLC1808                    ATOM  1685                                                                              CG TYR 268                                                                               23.625                                                                             44.400                                                                             38.058                                                                             1.00                                                                              15.29            1DLC1809                    ATOM  1686                                                                              CD1                                                                               TYR 268                                                                               23.588                                                                             44.852                                                                             39.378                                                                             1.00                                                                              17.01            1DLC1810                    ATOM  1687                                                                              CD2                                                                               TYR 268                                                                               23.808                                                                             45.344                                                                             37.042                                                                             1.00                                                                              12.55            1DLC1811                    ATOM  1688                                                                              CE1                                                                               TYR 268                                                                               23.720                                                                             46.207                                                                             39.685                                                                             1.00                                                                              18.91            1DLC1812                    ATOM  1689                                                                              CE2                                                                               TYR 268                                                                               23.937                                                                             46.703                                                                             37.335                                                                             1.00                                                                              15.35            1DLC1813                    ATOM  1690                                                                              CZ TYR 268                                                                               23.891                                                                             47.129                                                                             38.664                                                                             1.00                                                                              17.81            1DLC1814                    ATOM  1691                                                                              OH TYR 268                                                                               23.989                                                                             48.470                                                                             38.983                                                                             1.00                                                                              14.63            1DLC1815                    ATOM  1692                                                                              N  ARG 269                                                                               24.982                                                                             41.936                                                                             40.152                                                                             1.00                                                                              15.99            1DLC1816                    ATOM  1693                                                                              CA ARG 269                                                                               25.643                                                                             42.129                                                                             41.436                                                                             1.00                                                                              16.03            1DLC1817                    ATOM  1694                                                                              C  ARG 269                                                                               27.084                                                                             41.570                                                                             41.420                                                                             1.00                                                                              20.77            1DLC1818                    ATOM  1695                                                                              O  ARG 269                                                                               28.024                                                                             42.257                                                                             41.831                                                                             1.00                                                                              23.24            1DLC1819                    ATOM  1696                                                                              CB ARG 269                                                                               24.815                                                                             41.485                                                                             42.538                                                                             1.00                                                                              11.54            1DLC1820                    ATOM  1697                                                                              CG ARG 269                                                                               25.506                                                                             41.407                                                                             43.864                                                                             1.00                                                                              10.15            1DLC1821                    ATOM  1698                                                                              CD ARG 269                                                                               25.030                                                                             40.181                                                                             44.571                                                                             1.00                                                                              14.41            1DLC1822                    ATOM  1699                                                                              NE ARG 269                                                                               23.862                                                                             40.441                                                                             45.396                                                                             1.00                                                                              17.34            1DLC1823                    ATOM  1700                                                                              CZ ARG 269                                                                               22.933                                                                             39.541                                                                             45.710                                                                             1.00                                                                              21.53            1DLC1824                    ATOM  1701                                                                              NH1                                                                               ARG 269                                                                               22.991                                                                             38.292                                                                             45.259                                                                             1.00                                                                              20.03            1DLC1825                    ATOM  1702                                                                              NH2                                                                               ARG 269                                                                               21.977                                                                             39.878                                                                             46.558                                                                             1.00                                                                              26.32            1DLC1826                    ATOM  1703                                                                              N  ARG 270                                                                               27.263                                                                             40.350                                                                             40.907                                                                             1.00                                                                              20.00            1DLC1827                    ATOM  1704                                                                              CA ARG 270                                                                               28.592                                                                             39.749                                                                             40.821                                                                             1.00                                                                              19.69            1DLC1828                    ATOM  1705                                                                              C  ARG 270                                                                               29.517                                                                             40.503                                                                             39.850                                                                             1.00                                                                              19.79            1DLC1829                    ATOM  1706                                                                              O  ARG 270                                                                               30.647                                                                             40.841                                                                             40.199                                                                             1.00                                                                              23.48            1DLC1830                    ATOM  1707                                                                              CB ARG 270                                                                               28.509                                                                             38.285                                                                             40.386                                                                             1.00                                                                              21.51            1DLC1831                    ATOM  1708                                                                              CG ARG 270                                                                               29.863                                                                             37.543                                                                             40.405                                                                             1.00                                                                              22.79            1DLC1832                    ATOM  1709                                                                              CD ARG 270                                                                               29.949                                                                             36.544                                                                             39.258                                                                             1.00                                                                              23.46            1DLC1833                    ATOM  1710                                                                              NE ARG 270                                                                               28.710                                                                             35.781                                                                             39.194                                                                             1.00                                                                              27.60            1DLC1834                    ATOM  1711                                                                              CZ ARG 270                                                                               28.020                                                                             35.535                                                                             38.087                                                                             1.00                                                                              23.27            1DLC1835                    ATOM  1712                                                                              NH1                                                                               ARG 270                                                                               28.437                                                                             35.961                                                                             36.906                                                                             1.00                                                                              16.76            1DLC1836                    ATOM  1713                                                                              NH2                                                                               ARG 270                                                                               26.852                                                                             34.934                                                                             38.189                                                                             1.00                                                                              27.70            1DLC1837                    ATOM  1714                                                                              N  GLU 271                                                                               29.044                                                                             40.782                                                                             38.641                                                                             1.00                                                                              16.09            1DLC1838                    ATOM  1715                                                                              CA GLU 271                                                                               29.871                                                                             41.489                                                                             37.672                                                                             1.00                                                                              16.33            1DLC1839                    ATOM  1716                                                                              C  GLU 271                                                                               30.236                                                                             42.910                                                                             38.103                                                                             1.00                                                                              19.12            1DLC1840                    ATOM  1717                                                                              O  GLU 271                                                                               31.364                                                                             43.351                                                                             37.878                                                                             1.00                                                                              22.66            1DLC1841                    ATOM  1718                                                                              CB GLU 271                                                                               29.229                                                                             41.471                                                                             36.285                                                                             1.00                                                                              14.28            1DLC1842                    ATOM  1719                                                                              CG GLU 271                                                                               29.077                                                                             40.055                                                                             35.742                                                                             1.00                                                                              18.54            1DLC1843                    ATOM  1720                                                                              CD GLU 271                                                                               28.846                                                                             39.984                                                                             34.242                                                                             1.00                                                                              22.46            1DLC1844                    ATOM  1721                                                                              OE1                                                                               GLU 271                                                                               28.930                                                                             41.022                                                                             33.548                                                                             1.00                                                                              28.08            1DLC1845                    ATOM  1722                                                                              OE2                                                                               GLU 271                                                                               28.597                                                                             38.869                                                                             33.744                                                                             1.00                                                                              24.80            1DLC1846                    ATOM  1723                                                                              N  MET 272                                                                               29.305                                                                             43.616                                                                             38.745                                                                             1.00                                                                              17.93            1DLC1847                    ATOM  1724                                                                              CA MET 272                                                                               29.580                                                                             44.968                                                                             39.223                                                                             1.00                                                                              15.97            1DLC1848                    ATOM  1725                                                                              C  MET 272                                                                               30.544                                                                             44.914                                                                             40.405                                                                             1.00                                                                              16.81            1DLC1849                    ATOM  1726                                                                              O  MET 272                                                                               31.253                                                                             45.876                                                                             40.684                                                                             1.00                                                                              20.74            1DLC1850                    ATOM  1727                                                                              CB MET 272                                                                               28.300                                                                             45.705                                                                             39.616                                                                             1.00                                                                              14.65            1DLC1851                    ATOM  1728                                                                              CG MET 272                                                                               27.362                                                                             45.953                                                                             38.464                                                                             1.00                                                                              20.31            1DLC1852                    ATOM  1729                                                                              SD MET 272                                                                               28.183                                                                             46.581                                                                             36.973                                                                             1.00                                                                              27.85            1DLC1853                    ATOM  1730                                                                              CE MET 272                                                                               27.795                                                                             48.276                                                                             37.085                                                                             1.00                                                                              32.60            1DLC1854                    ATOM  1731                                                                              N  THR 273                                                                               30.571                                                                             43.789                                                                             41.104                                                                             1.00                                                                              14.53            1DLC1855                    ATOM  1732                                                                              CA THR 273                                                                               31.491                                                                             43.631                                                                             42.220                                                                             1.00                                                                              16.38            1DLC1856                    ATOM  1733                                                                              C  THR 273                                                                               32.931                                                                             43.495                                                                             41.701                                                                             1.00                                                                              17.79            1DLC1857                    ATOM  1734                                                                              O  THR 273                                                                               33.835                                                                             44.207                                                                             42.142                                                                             1.00                                                                              19.00            1DLC1858                    ATOM  1735                                                                              CB THR 273                                                                               31.130                                                                             42.402                                                                             43.072                                                                             1.00                                                                              13.43            1DLC1859                    ATOM  1736                                                                              OG1                                                                               THR 273                                                                               29.875                                                                             42.632                                                                             43.716                                                                             1.00                                                                              13.76            1DLC1860                    ATOM  1737                                                                              CG2                                                                               THR 273                                                                               32.190                                                                             42.146                                                                             44.139                                                                             1.00                                                                              12.75            1DLC1861                    ATOM  1738                                                                              N  LEU 274                                                                               33.108                                                                             42.634                                                                             40.702                                                                             1.00                                                                              18.60            1DLC1862                    ATOM  1739                                                                              CA LEU 274                                                                               34.413                                                                             42.376                                                                             40.100                                                                             1.00                                                                              17.81            1DLC1863                    ATOM  1740                                                                              C  LEU 274                                                                               35.000                                                                             43.542                                                                             39.305                                                                             1.00                                                                              18.48            1DLC1864                    ATOM  1741                                                                              O  LEU 274                                                                               36.214                                                                             43.754                                                                             39.306                                                                             1.00                                                                              23.04            1DLC1865                    ATOM  1742                                                                              CB LEU 274                                                                               34.340                                                                             41.136                                                                             39.198                                                                             1.00                                                                              10.87            1DLC1866                    ATOM  1743                                                                              CG LEU 274                                                                               33.850                                                                             39.850                                                                             39.870                                                                             1.00                                                                              11.27            1DLC1867                    ATOM  1744                                                                              CD1                                                                               LEU 274                                                                               33.801                                                                             38.730                                                                             38.867                                                                             1.00                                                                              10.38            1DLC1868                    ATOM  1745                                                                              CD2                                                                               LEU 274                                                                               34.735                                                                             39.476                                                                             41.047                                                                             1.00                                                                              9.69             1DLC1869                    ATOM  1746                                                                              N  THR 275                                                                               34.143                                                                             44.300                                                                             38.632                                                                             1.00                                                                              16.36            1DLC1870                    ATOM  1747                                                                              CA THR 275                                                                               34.611                                                                             45.412                                                                             37.813                                                                             1.00                                                                              16.92            1DLC1871                    ATOM  1748                                                                              C  THR 275                                                                               34.489                                                                             46.807                                                                             38.413                                                                             1.00                                                                              18.24            1DLC1872                    ATOM  1749                                                                              O  THR 275                                                                               35.169                                                                             47.734                                                                             37.967                                                                             1.00                                                                              22.33            1DLC1873                    ATOM  1750                                                                              CB THR 275                                                                               33.932                                                                             45.417                                                                             36.421                                                                             1.00                                                                              16.38            1DLC1874                    ATOM  1751                                                                              OG1                                                                               THR 275                                                                               32.508                                                                             45.523                                                                             36.581                                                                             1.00                                                                              22.03            1DLC1875                    ATOM  1752                                                                              CG2                                                                               THR 275                                                                               34.259                                                                             44.148                                                                             35.663                                                                             1.00                                                                              13.77            1DLC1876                    ATOM  1753                                                                              N  VAL 276                                                                               33.626                                                                             46.972                                                                             39.410                                                                             1.00                                                                              17.04            1DLC1877                    ATOM  1754                                                                              CA VAL 276                                                                               33.443                                                                             48.287                                                                             40.021                                                                             1.00                                                                              14.32            1DLC1878                    ATOM  1755                                                                              C  VAL 276                                                                               33.739                                                                             48.366                                                                             41.523                                                                             1.00                                                                              15.28            1DLC1879                    ATOM  1756                                                                              O  VAL 276                                                                               34.637                                                                             49.093                                                                             41.949                                                                             1.00                                                                              15.38            1DLC1880                    ATOM  1757                                                                              CB VAL 276                                                                               32.008                                                                             48.832                                                                             39.749                                                                             1.00                                                                              14.77            1DLC1881                    ATOM  1758                                                                              CG1                                                                               VAL 276                                                                               31.796                                                                             50.185                                                                             40.439                                                                             1.00                                                                              14.41            1DLC1882                    ATOM  1759                                                                              CG2                                                                               VAL 276                                                                               31.764                                                                             48.963                                                                             38.250                                                                             1.00                                                                              10.22            1DLC1883                    ATOM  1760                                                                              N  LEU 277                                                                               33.005                                                                             47.585                                                                             42.311                                                                             1.00                                                                              17.20            1DLC1884                    ATOM  1761                                                                              CA LEU 277                                                                               33.137                                                                             47.596                                                                             43.767                                                                             1.00                                                                              16.40            1DLC1885                    ATOM  1762                                                                              C  LEU 277                                                                               34.504                                                                             47.219                                                                             44.330                                                                             1.00                                                                              16.22            1DLC1886                    ATOM  1763                                                                              O  LEU 277                                                                               34.967                                                                             47.831                                                                             45.294                                                                             1.00                                                                              16.50            1DLC1887                    ATOM  1764                                                                              CB LEU 277                                                                               32.009                                                                             46.781                                                                             44.421                                                                             1.00                                                                              13.32            1DLC1888                    ATOM  1765                                                                              CG LEU 277                                                                               30.565                                                                             47.184                                                                             44.067                                                                             1.00                                                                              10.97            1DLC1889                    ATOM  1766                                                                              CD1                                                                               LEU 277                                                                               29.609                                                                             46.395                                                                             44.928                                                                             1.00                                                                              10.44            1DLC1890                    ATOM  1767                                                                              CD2                                                                               LEU 277                                                                               30.326                                                                             48.681                                                                             44.254                                                                             1.00                                                                              5.94             1DLC1891                    ATOM  1768                                                                              N  ASP 278                                                                               35.143                                                                             46.210                                                                             43.747                                                                             1.00                                                                              16.09            1DLC1892                    ATOM  1769                                                                              CA ASP 278                                                                               36.484                                                                             45.792                                                                             44.188                                                                             1.00                                                                              17.29            1DLC1893                    ATOM  1770                                                                              C  ASP 278                                                                               37.503                                                                             46.892                                                                             43.892                                                                             1.00                                                                              17.61            1DLC1894                    ATOM  1771                                                                              O  ASP 278                                                                               38.430                                                                             47.134                                                                             44.659                                                                             1.00                                                                              20.19            1DLC1895                    ATOM  1772                                                                              CB ASP 278                                                                               36.923                                                                             44.506                                                                             43.469                                                                             1.00                                                                              16.99            1DLC1896                    ATOM  1773                                                                              CG ASP 278                                                                               36.247                                                                             43.269                                                                             44.015                                                                             1.00                                                                              15.27            1DLC1897                    ATOM  1774                                                                              OD1                                                                               ASP 278                                                                               35.693                                                                             43.336                                                                             45.127                                                                             1.00                                                                              18.92            1DLC1898                    ATOM  1775                                                                              OD2                                                                               ASP 278                                                                               36.270                                                                             42.229                                                                             43.336                                                                             1.00                                                                              18.16            1DLC1899                    ATOM  1776                                                                              N  LEU 279                                                                               37.281                                                                             47.579                                                                             42.778                                                                             1.00                                                                              20.55            1DLC1900                    ATOM  1777                                                                              CA LEU 279                                                                               38.137                                                                             48.660                                                                             42.317                                                                             1.00                                                                              19.58            1DLC1901                    ATOM  1778                                                                              C  LEU 279                                                                               38.086                                                                             49.881                                                                             43.234                                                                             1.00                                                                              19.74            1DLC1902                    ATOM  1779                                                                              O  LEU 279                                                                               39.128                                                                             50.342                                                                             43.710                                                                             1.00                                                                              22.71            1DLC1903                    ATOM  1780                                                                              CB LEU 279                                                                               37.734                                                                             49.052                                                                             40.893                                                                             1.00                                                                              17.72            1DLC1904                    ATOM  1781                                                                              CG LEU 279                                                                               38.749                                                                             49.808                                                                             40.046                                                                             1.00                                                                              16.46            1DLC1905                    ATOM  1782                                                                              CD1                                                                               LEU 279                                                                               40.052                                                                             49.031                                                                             40.000                                                                             1.00                                                                              14.94            1DLC1906                    ATOM  1783                                                                              CD2                                                                               LEU 279                                                                               38.188                                                                             49.989                                                                             38.641                                                                             1.00                                                                              16.14            1DLC1907                    ATOM  1784                                                                              N  ILE 280                                                                               36.879                                                                             50.375                                                                             43.517                                                                             1.00                                                                              18.89            1DLC1908                    ATOM  1785                                                                              CA ILE 280                                                                               36.719                                                                             51.560                                                                             44.366                                                                             1.00                                                                              13.41            1DLC1909                    ATOM  1786                                                                              C  ILE 280                                                                               37.199                                                                             51.324                                                                             45.798                                                                             1.00                                                                              13.89            1DLC1910                    ATOM  1787                                                                              O  ILE 280                                                                               37.507                                                                             52.267                                                                             46.526                                                                             1.00                                                                              13.40            1DLC1911                    ATOM  1788                                                                              CB ILE 280                                                                               35.256                                                                             52.105                                                                             44.363                                                                             1.00                                                                              14.32            1DLC1912                    ATOM  1789                                                                              CG1                                                                               ILE 280                                                                               34.321                                                                             51.163                                                                             45.122                                                                             1.00                                                                              13.32            1DLC1913                    ATOM  1790                                                                              CG2                                                                               ILE 280                                                                               34.761                                                                             52.313                                                                             42.923                                                                             1.00                                                                              13.11            1DLC1914                    ATOM  1791                                                                              CD1                                                                               ILE 280                                                                               32.919                                                                             51.689                                                                             45.250                                                                             1.00                                                                              13.97            1DLC1915                    ATOM  1792                                                                              N  ALA 281                                                                               37.279                                                                             50.057                                                                             46.190                                                                             1.00                                                                              14.85            1DLC1916                    ATOM  1793                                                                              CA ALA 281                                                                               37.753                                                                             49.696                                                                             47.523                                                                             1.00                                                                              14.09            1DLC1917                    ATOM  1794                                                                              C  ALA 281                                                                               39.244                                                                             50.047                                                                             47.686                                                                             1.00                                                                              16.05            1DLC1918                    ATOM  1795                                                                              O  ALA 281                                                                               39.711                                                                             50.300                                                                             48.792                                                                             1.00                                                                              19.60            1DLC1919                    ATOM  1796                                                                              CB ALA 281                                                                               37.534                                                                             48.218                                                                             47.758                                                                             1.00                                                                              10.28            1DLC1920                    ATOM  1797                                                                              N  LEU 282                                                                               39.968                                                                             50.109                                                                             46.568                                                                             1.00                                                                              17.34            1DLC1921                    ATOM  1798                                                                              CA LEU 282                                                                               41.404                                                                             50.412                                                                             46.566                                                                             1.00                                                                              17.85            1DLC1922                    ATOM  1799                                                                              C  LEU 282                                                                               41.772                                                                             51.901                                                                             46.551                                                                             1.00                                                                              18.73            1DLC1923                    ATOM  1800                                                                              O  LEU 282                                                                               42.853                                                                             52.282                                                                             47.002                                                                             1.00                                                                              20.35            1DLC1924                    ATOM  1801                                                                              CB LEU 282                                                                               42.088                                                                             49.692                                                                             45.396                                                                             1.00                                                                              13.56            1DLC1925                    ATOM  1802                                                                              CG LEU 282                                                                               41.818                                                                             48.181                                                                             45.369                                                                             1.00                                                                              15.77            1DLC1926                    ATOM  1803                                                                              CD1                                                                               LEU 282                                                                               42.557                                                                             47.527                                                                             44.222                                                                             1.00                                                                              15.69            1DLC1927                    ATOM  1804                                                                              CD2                                                                               LEU 282                                                                               42.219                                                                             47.554                                                                             46.693                                                                             1.00                                                                              11.02            1DLC1928                    ATOM  1805                                                                              N  PHE 283                                                                               40.853                                                                             52.738                                                                             46.078                                                                             1.00                                                                              17.57            1DLC1929                    ATOM  1806                                                                              CA PHE 283                                                                               41.056                                                                             54.189                                                                             45.993                                                                             1.00                                                                              16.08            1DLC1930                    ATOM  1807                                                                              C  PHE 283                                                                               41.766                                                                             54.859                                                                             47.190                                                                             1.00                                                                              17.36            1DLC1931                    ATOM  1808                                                                              O  PHE 283                                                                               42.711                                                                             55.622                                                                             47.003                                                                             1.00                                                                              18.59            1DLC1932                    ATOM  1809                                                                              CB PHE 283                                                                               39.714                                                                             54.910                                                                             45.750                                                                             1.00                                                                              16.79            1DLC1933                    ATOM  1810                                                                              CG PHE 283                                                                               39.107                                                                             54.676                                                                             44.384                                                                             1.00                                                                              11.95            1DLC1934                    ATOM  1811                                                                              CD1                                                                               PHE 283                                                                               39.792                                                                             53.973                                                                             43.397                                                                             1.00                                                                              9.94             1DLC1935                    ATOM  1812                                                                              CD2                                                                               PHE 283                                                                               37.851                                                                             55.199                                                                             44.083                                                                             1.00                                                                              11.93            1DLC1936                    ATOM  1813                                                                              CE1                                                                               PHE 283                                                                               39.231                                                                             53.797                                                                             42.123                                                                             1.00                                                                              15.02            1DLC1937                    ATOM  1814                                                                              CE2                                                                               PHE 283                                                                               37.284                                                                             55.027                                                                             42.815                                                                             1.00                                                                              13.95            1DLC1938                    ATOM  1815                                                                              CZ PHE 283                                                                               37.978                                                                             54.325                                                                             41.832                                                                             1.00                                                                              8.45             1DLC1939                    ATOM  1816                                                                              N  PRO 284                                                                               41.325                                                                             54.577                                                                             48.432                                                                             1.00                                                                              16.44            1DLC1940                    ATOM  1817                                                                              CA PRO 284                                                                               41.954                                                                             55.188                                                                             49.613                                                                             1.00                                                                              16.04            1DLC1941                    ATOM  1818                                                                              C  PRO 284                                                                               43.435                                                                             54.855                                                                             49.775                                                                             1.00                                                                              18.64            1DLC1942                    ATOM  1819                                                                              O  PRO 284                                                                               44.206                                                                             55.624                                                                             50.357                                                                             1.00                                                                              20.90            1DLC1943                    ATOM  1820                                                                              CB PRO 284                                                                               41.154                                                                             54.593                                                                             50.771                                                                             1.00                                                                              11.65            1DLC1944                    ATOM  1821                                                                              CG PRO 284                                                                               39.841                                                                             54.292                                                                             50.168                                                                             1.00                                                                              13.79            1DLC1945                    ATOM  1822                                                                              CD PRO 284                                                                               40.210                                                                             53.707                                                                             48.843                                                                             1.00                                                                              14.01            1DLC1946                    ATOM  1823                                                                              N  LEU 285                                                                               43.825                                                                             53.697                                                                             49.263                                                                             1.00                                                                              19.68            1DLC1947                    ATOM  1824                                                                              CA LEU 285                                                                               45.198                                                                             53.244                                                                             49.366                                                                             1.00                                                                              17.84            1DLC1948                    ATOM  1825                                                                              C  LEU 285                                                                               46.126                                                                             53.959                                                                             48.383                                                                             1.00                                                                              17.73            1DLC1949                    ATOM  1826                                                                              O  LEU 285                                                                               47.334                                                                             53.743                                                                             48.391                                                                             1.00                                                                              22.07            1DLC1950                    ATOM  1827                                                                              CB LEU 285                                                                               45.248                                                                             51.719                                                                             49.220                                                                             1.00                                                                              19.70            1DLC1951                    ATOM  1828                                                                              CG LEU 285                                                                               44.269                                                                             50.970                                                                             50.149                                                                             1.00                                                                              20.17            1DLC1952                    ATOM  1829                                                                              CD1                                                                               LEU 285                                                                               44.337                                                                             49.484                                                                             49.897                                                                             1.00                                                                              22.11            1DLC1953                    ATOM  1830                                                                              CD2                                                                               LEU 285                                                                               44.558                                                                             51.263                                                                             51.609                                                                             1.00                                                                              17.27            1DLC1954                    ATOM  1831                                                                              N  TYR 286                                                                               45.554                                                                             54.817                                                                             47.543                                                                             1.00                                                                              17.08            1DLC1955                    ATOM  1832                                                                              CA TYR 286                                                                               46.335                                                                             55.608                                                                             46.588                                                                             1.00                                                                              16.87            1DLC1956                    ATOM  1833                                                                              C  TYR 286                                                                               46.878                                                                             56.856                                                                             47.292                                                                             1.00                                                                              17.31            1DLC1957                    ATOM  1834                                                                              O  TYR 286                                                                               47.635                                                                             57.630                                                                             46.709                                                                             1.00                                                                              18.04            1DLC1958                    ATOM  1835                                                                              CB TYR 286                                                                               45.484                                                                             56.044                                                                             45.395                                                                             1.00                                                                              15.25            1DLC1959                    ATOM  1836                                                                              CG TYR 286                                                                               44.982                                                                             54.917                                                                             44.529                                                                             1.00                                                                              17.75            1DLC1960                    ATOM  1837                                                                              CD1                                                                               TYR 286                                                                               45.468                                                                             53.615                                                                             44.680                                                                             1.00                                                                              19.64            1DLC1961                    ATOM  1838                                                                              CD2                                                                               TYR 286                                                                               44.008                                                                             55.149                                                                             43.559                                                                             1.00                                                                              19.56            1DLC1962                    ATOM  1839                                                                              CE1                                                                               TYR 286                                                                               44.990                                                                             52.579                                                                             43.888                                                                             1.00                                                                              19.02            1DLC1963                    ATOM  1840                                                                              CE2                                                                               TYR 286                                                                               43.526                                                                             54.121                                                                             42.763                                                                             1.00                                                                              17.69            1DLC1964                    ATOM  1841                                                                              CZ TYR 286                                                                               44.016                                                                             52.846                                                                             42.933                                                                             1.00                                                                              17.71            1DLC1965                    ATOM  1842                                                                              OH TYR 286                                                                               43.507                                                                             51.832                                                                             42.166                                                                             1.00                                                                              19.21            1DLC1966                    ATOM  1843                                                                              N  ASP 287                                                                               46.449                                                                             57.080                                                                             48.531                                                                             1.00                                                                              15.82            1DLC1967                    ATOM  1844                                                                              CA ASP 287                                                                               46.942                                                                             58.221                                                                             49.279                                                                             1.00                                                                              15.74            1DLC1968                    ATOM  1845                                                                              C  ASP 287                                                                               48.293                                                                             57.856                                                                             49.888                                                                             1.00                                                                              15.59            1DLC1969                    ATOM  1846                                                                              O  ASP 287                                                                               48.376                                                                             57.359                                                                             51.013                                                                             1.00                                                                              15.25            1DLC1970                    ATOM  1847                                                                              CB ASP 287                                                                               45.958                                                                             58.648                                                                             50.365                                                                             1.00                                                                              14.24            1DLC1971                    ATOM  1848                                                                              CG ASP 287                                                                               46.307                                                                             60.007                                                                             50.970                                                                             1.00                                                                              19.57            1DLC1972                    ATOM  1849                                                                              OD1                                                                               ASP 287                                                                               47.482                                                                             60.422                                                                             50.914                                                                             1.00                                                                              23.20            1DLC1973                    ATOM  1850                                                                              OD2                                                                               ASP 287                                                                               45.405                                                                             60.672                                                                             51.519                                                                             1.00                                                                              24.37            1DLC1974                    ATOM  1851                                                                              N  VAL 288                                                                               49.352                                                                             58.154                                                                             49.142                                                                             1.00                                                                              17.00            1DLC1975                    ATOM  1852                                                                              CA VAL 288                                                                               50.717                                                                             57.860                                                                             49.564                                                                             1.00                                                                              19.40            1DLC1976                    ATOM  1853                                                                              C  VAL 288                                                                               51.236                                                                             58.650                                                                             50.761                                                                             1.00                                                                              20.76            1DLC1977                    ATOM  1854                                                                              O  VAL 288                                                                               52.334                                                                             58.403                                                                             51.236                                                                             1.00                                                                              24.76            1DLC1978                    ATOM  1855                                                                              CB VAL 288                                                                               51.702                                                                             57.989                                                                             48.397                                                                             1.00                                                                              17.31            1DLC1979                    ATOM  1856                                                                              CG1                                                                               VAL 288                                                                               51.291                                                                             57.054                                                                             47.285                                                                             1.00                                                                              18.35            1DLC1980                    ATOM  1857                                                                              CG2                                                                               VAL 288                                                                               51.762                                                                             59.418                                                                             47.905                                                                             1.00                                                                              17.23            1DLC1981                    ATOM  1858                                                                              N  ARG 289                                                                               50.447                                                                             59.598                                                                             51.248                                                                             1.00                                                                              23.06            1DLC1982                    ATOM  1859                                                                              CA ARG 289                                                                               50.846                                                                             60.391                                                                             52.410                                                                             1.00                                                                              22.35            1DLC1983                    ATOM  1860                                                                              C  ARG 289                                                                               50.361                                                                             59.717                                                                             53.669                                                                             1.00                                                                              20.93            1DLC1984                    ATOM  1861                                                                              O  ARG 289                                                                               51.051                                                                             59.715                                                                             54.684                                                                             1.00                                                                              21.28            1DLC1985                    ATOM  1862                                                                              CB ARG 289                                                                               50.283                                                                             61.800                                                                             52.311                                                                             1.00                                                                              28.20            1DLC1986                    ATOM  1863                                                                              CG ARG 289                                                                               50.680                                                                             62.438                                                                             51.025                                                                             1.00                                                                              31.27            1DLC1987                    ATOM  1864                                                                              CD ARG 289                                                                               50.447                                                                             63.905                                                                             51.004                                                                             1.00                                                                              41.78            1DLC1988                    ATOM  1865                                                                              NE ARG 289                                                                               51.389                                                                             64.454                                                                             50.046                                                                             1.00                                                                              51.47            1DLC1989                    ATOM  1866                                                                              CZ ARG 289                                                                               52.620                                                                             64.833                                                                             50.361                                                                             1.00                                                                              52.65            1DLC1990                    ATOM  1867                                                                              NH1                                                                               ARG 289                                                                               53.034                                                                             64.743                                                                             51.621                                                                             1.00                                                                              52.33            1DLC1991                    ATOM  1868                                                                              NH2                                                                               ARG 289                                                                               53.469                                                                             65.194                                                                             49.403                                                                             1.00                                                                              53.49            1DLC1992                    ATOM  1869                                                                              N  LEU 290                                                                               49.142                                                                             59.187                                                                             53.599                                                                             1.00                                                                              21.77            1DLC1993                    ATOM  1870                                                                              CA LEU 290                                                                               48.535                                                                             58.454                                                                             54.710                                                                             1.00                                                                              19.60            1DLC1994                    ATOM  1871                                                                              C  LEU 290                                                                               49.127                                                                             57.042                                                                             54.690                                                                             1.00                                                                              19.04            1DLC1995                    ATOM  1872                                                                              O  LEU 290                                                                               49.307                                                                             56.414                                                                             55.728                                                                             1.00                                                                              16.89            1DLC1996                    ATOM  1873                                                                              CB LEU 290                                                                               47.014                                                                             58.368                                                                             54.545                                                                             1.00                                                                              17.72            1DLC1997                    ATOM  1874                                                                              CG LEU 290                                                                               46.117                                                                             59.392                                                                             55.235                                                                             1.00                                                                              17.03            1DLC1998                    ATOM  1875                                                                              CD1                                                                               LEU 290                                                                               44.683                                                                             58.999                                                                             54.982                                                                             1.00                                                                              15.20            1DLC1999                    ATOM  1876                                                                              CD2                                                                               LEU 290                                                                               46.382                                                                             59.429                                                                             56.728                                                                             1.00                                                                              13.88            1DLC2000                    ATOM  1877                                                                              N  TYR 291                                                                               49.429                                                                             56.555                                                                             53.490                                                                             1.00                                                                              17.26            1DLC2001                    ATOM  1878                                                                              CA TYR 291                                                                               50.018                                                                             55.231                                                                             53.316                                                                             1.00                                                                              17.98            1DLC2002                    ATOM  1879                                                                              C  TYR 291                                                                               51.379                                                                             55.394                                                                             52.648                                                                             1.00                                                                              19.81            1DLC2003                    ATOM  1880                                                                              O  TYR 291                                                                               51.533                                                                             55.142                                                                             51.448                                                                             1.00                                                                              19.73            1DLC2004                    ATOM  1881                                                                              CB TYR 291                                                                               49.092                                                                             54.352                                                                             52.475                                                                             1.00                                                                              16.70            1DLC2005                    ATOM  1882                                                                              CG TYR 291                                                                               47.755                                                                             54.103                                                                             53.142                                                                             1.00                                                                              17.30            1DLC2006                    ATOM  1883                                                                              CD1                                                                               TYR 291                                                                               47.582                                                                             53.028                                                                             54.024                                                                             1.00                                                                              15.12            1DLC2007                    ATOM  1884                                                                              CD2                                                                               TYR 291                                                                               46.674                                                                             54.963                                                                             52.927                                                                             1.00                                                                              12.11            1DLC2008                    ATOM  1885                                                                              CE1                                                                               TYR 291                                                                               46.379                                                                             52.820                                                                             54.672                                                                             1.00                                                                              15.98            1DLC2009                    ATOM  1886                                                                              CE2                                                                               TYR 291                                                                               45.469                                                                             54.763                                                                             53.576                                                                             1.00                                                                              11.41            1DLC2010                    ATOM  1887                                                                              CZ TYR 291                                                                               45.330                                                                             53.689                                                                             54.444                                                                             1.00                                                                              13.44            1DLC2011                    ATOM  1888                                                                              OH TYR 291                                                                               44.140                                                                             53.472                                                                             55.077                                                                             1.00                                                                              16.97            1DLC2012                    ATOM  1889                                                                              N  PRO 292                                                                               52.383                                                                             55.841                                                                             53.428                                                                             1.00                                                                              18.71            1DLC2013                    ATOM  1890                                                                              CA PRO 292                                                                               53.760                                                                             56.078                                                                             52.988                                                                             1.00                                                                              19.79            1DLC2014                    ATOM  1891                                                                              C  PRO 292                                                                               54.569                                                                             54.810                                                                             52.769                                                                             1.00                                                                              21.30            1DLC2015                    ATOM  1892                                                                              O  PRO 292                                                                               55.746                                                                             54.877                                                                             52.441                                                                             1.00                                                                              27.34            1DLC2016                    ATOM  1893                                                                              CB PRO 292                                                                               54.351                                                                             56.913                                                                             54.127                                                                             1.00                                                                              20.00            1DLC2017                    ATOM  1894                                                                              CG PRO 292                                                                               53.159                                                                             57.371                                                                             54.919                                                                             1.00                                                                              24.03            1DLC2018                    ATOM  1895                                                                              CD PRO 292                                                                               52.248                                                                             56.202                                                                             54.843                                                                             1.00                                                                              17.48            1DLC2019                    ATOM  1896                                                                              N  LYS 293                                                                               53.959                                                                             53.657                                                                             53.010                                                                             1.00                                                                              20.08            1DLC2020                    ATOM  1897                                                                              CA LYS 293                                                                               54.625                                                                             52.381                                                                             52.793                                                                             1.00                                                                              20.58            1DLC2021                    ATOM  1898                                                                              C  LYS 293                                                                               53.692                                                                             51.508                                                                             51.950                                                                             1.00                                                                              23.91            1DLC2022                    ATOM  1899                                                                              O  LYS 293                                                                               52.543                                                                             51.884                                                                             51.690                                                                             1.00                                                                              27.52            1DLC2023                    ATOM  1900                                                                              CB LYS 293                                                                               54.881                                                                             51.655                                                                             54.114                                                                             1.00                                                                              17.96            1DLC2024                    ATOM  1901                                                                              CG LYS 293                                                                               55.286                                                                             52.512                                                                             55.267                                                                             1.00                                                                              20.88            1DLC2025                    ATOM  1902                                                                              CD LYS 293                                                                               55.560                                                                             51.644                                                                             56.484                                                                             1.00                                                                              25.87            1DLC2026                    ATOM  1903                                                                              CE LYS 293                                                                               55.546                                                                             52.459                                                                             57.770                                                                             1.00                                                                              34.09            1DLC2027                    ATOM  1904                                                                              NZ LYS 293                                                                               56.452                                                                             53.641                                                                             57.721                                                                             1.00                                                                              38.99            1DLC2028                    ATOM  1905                                                                              N  GLU 294                                                                               54.180                                                                             50.345                                                                             51.530                                                                             1.00                                                                              22.97            1DLC2029                    ATOM  1906                                                                              CA GLU 294                                                                               53.359                                                                             49.411                                                                             50.772                                                                             1.00                                                                              20.92            1DLC2030                    ATOM  1907                                                                              C  GLU 294                                                                               52.267                                                                             48.916                                                                             51.722                                                                             1.00                                                                              20.22            1DLC2031                    ATOM  1908                                                                              O  GLU 294                                                                               52.471                                                                             48.835                                                                             52.938                                                                             1.00                                                                              19.74            1DLC2032                    ATOM  1909                                                                              CB GLU 294                                                                               54.192                                                                             48.218                                                                             50.314                                                                             1.00                                                                              24.35            1DLC2033                    ATOM  1910                                                                              CG GLU 294                                                                               55.435                                                                             48.586                                                                             49.521                                                                             1.00                                                                              36.21            1DLC2034                    ATOM  1911                                                                              CD GLU 294                                                                               56.236                                                                             47.367                                                                             49.086                                                                             1.00                                                                              37.88            1DLC2035                    ATOM  1912                                                                              OE1                                                                               GLU 294                                                                               56.648                                                                             46.574                                                                             49.966                                                                             1.00                                                                              43.62            1DLC2036                    ATOM  1913                                                                              OE2                                                                               GLU 294                                                                               56.450                                                                             47.207                                                                             47.864                                                                             1.00                                                                              40.00            1DLC2037                    ATOM  1914                                                                              N  VAL 295                                                                               51.101                                                                             48.607                                                                             51.177                                                                             1.00                                                                              21.65            1DLC2038                    ATOM  1915                                                                              CA VAL 295                                                                               49.999                                                                             48.127                                                                             52.002                                                                             1.00                                                                              21.78            1DLC2039                    ATOM  1916                                                                              C  VAL 295                                                                               49.628                                                                             46.669                                                                             51.752                                                                             1.00                                                                              20.58            1DLC2040                    ATOM  1917                                                                              O  VAL 295                                                                               49.519                                                                             46.236                                                                             50.608                                                                             1.00                                                                              21.08            SDLC2041                    ATOM  1918                                                                              CB VAL 295                                                                               48.732                                                                             48.989                                                                             51.809                                                                             1.00                                                                              20.64            1DLC2042                    ATOM  1919                                                                              CG1                                                                               VAL 295                                                                               47.553                                                                             48.390                                                                             52.569                                                                             1.00                                                                              22.03            1DLC2043                    ATOM  1920                                                                              CG2                                                                               VAL 295                                                                               48.991                                                                             50.400                                                                             52.284                                                                             1.00                                                                              22.52            1DLC2044                    ATOM  1921                                                                              N  LYS 296                                                                               49.509                                                                             45.905                                                                             52.834                                                                             1.00                                                                              18.88            1DLC2045                    ATOM  1922                                                                              CA LYS 296                                                                               49.082                                                                             44.516                                                                             52.754                                                                             1.00                                                                              17.81            1DLC2046                    ATOM  1923                                                                              C  LYS 296                                                                               47.586                                                                             44.560                                                                             53.085                                                                             1.00                                                                              20.39            1DLC2047                    ATOM  1924                                                                              O  LYS 296                                                                               47.195                                                                             45.013                                                                             54.172                                                                             1.00                                                                              20.26            1DLC2048                    ATOM  1925                                                                              CB LYS 296                                                                               49.809                                                                             43.651                                                                             53.782                                                                             1.00                                                                              15.08            1DLC2049                    ATOM  1926                                                                              CG LYS 296                                                                               49.313                                                                             42.216                                                                             53.816                                                                             1.00                                                                              12.45            1DLC2050                    ATOM  1927                                                                              CD LYS 296                                                                               49.980                                                                             41.428                                                                             54.928                                                                             1.00                                                                              16.66            1DLC2051                    ATOM  1928                                                                              CE LYS 296                                                                               49.434                                                                             40.008                                                                             55.028                                                                             1.00                                                                              12.92            1DLC2052                    ATOM  1929                                                                              NZ LYS 296                                                                               48.362                                                                             39.892                                                                             56.047                                                                             1.00                                                                              15.35            1DLC2053                    ATOM  1930                                                                              N  THR 297                                                                               46.747                                                                             44.166                                                                             52.135                                                                             1.00                                                                              20.26            1DLC2054                    ATOM  1931                                                                              CA THR 297                                                                               45.309                                                                             44.186                                                                             52.373                                                                             1.00                                                                              19.90            1DLC2055                    ATOM  1932                                                                              C  THR 297                                                                               44.572                                                                             43.049                                                                             51.671                                                                             1.00                                                                              19.99            1DLC2056                    ATOM  1933                                                                              O  THR 297                                                                               45.177                                                                             42.286                                                                             50.923                                                                             1.00                                                                              24.16            1DLC2057                    ATOM  1934                                                                              CB THR 297                                                                               44.701                                                                             45.550                                                                             51.980                                                                             1.00                                                                              17.52            1DLC2058                    ATOM  1935                                                                              OG1                                                                               THR 297                                                                               43.325                                                                             45.579                                                                             52.366                                                                             1.00                                                                              18.25            1DLC2059                    ATOM  1936                                                                              CG2                                                                               THR 297                                                                               44.829                                                                             45.799                                                                             50.476                                                                             1.00                                                                              14.77            1DLC2060                    ATOM  1937                                                                              N  GLU 298                                                                               43.270                                                                             42.935                                                                             51.913                                                                             1.00                                                                              20.33            1DLC2061                    ATOM  1938                                                                              CA GLU 298                                                                               42.461                                                                             41.874                                                                             51.307                                                                             1.00                                                                              19.29            1DLC2062                    ATOM  1939                                                                              C  GLU 298                                                                               40.997                                                                             42.259                                                                             51.106                                                                             1.00                                                                              17.75            1DLC2063                    ATOM  1940                                                                              O  GLU 298                                                                               40.470                                                                             43.129                                                                             51.795                                                                             1.00                                                                              20.54            1DLC2064                    ATOM  1941                                                                              CB GLU 298                                                                               42.536                                                                             40.605                                                                             52.166                                                                             1.00                                                                              14.48            1DLC2065                    ATOM  1942                                                                              CG GLU 298                                                                               42.130                                                                             40.827                                                                             53.611                                                                             1.00                                                                              14.45            1DLC2066                    ATOM  1943                                                                              CD GLU 298                                                                               42.441                                                                             39.644                                                                             54.506                                                                             1.00                                                                              15.68            1DLC2067                    ATOM  1944                                                                              OE1                                                                               GLU 298                                                                               43.588                                                                             39.157                                                                             54.490                                                                             1.00                                                                              22.29            1DLC2068                    ATOM  1945                                                                              OE2                                                                               GLU 298                                                                               41.544                                                                             39.211                                                                             55.247                                                                             1.00                                                                              19.26            1DLC2069                    ATOM  1946                                                                              N  LEU 299                                                                               40.349                                                                             41.596                                                                             50.156                                                                             1.00                                                                              17.55            1DLC2070                    ATOM  1947                                                                              CA LEU 299                                                                               38.933                                                                             41.826                                                                             49.856                                                                             1.00                                                                              18.90            1DLC2071                    ATOM  1948                                                                              C  LEU 299                                                                               38.165                                                                             40.652                                                                             50.488                                                                             1.00                                                                              21.39            1DLC2072                    ATOM  1949                                                                              O  LEU 299                                                                               38.385                                                                             39.493                                                                             50.108                                                                             1.00                                                                              23.60            1DLC2073                    ATOM  1950                                                                              CB LEU 299                                                                               38.717                                                                             41.862                                                                             48.338                                                                             1.00                                                                              13.32            1DLC2074                    ATOM  1951                                                                              CG LEU 299                                                                               39.472                                                                             42.945                                                                             47.563                                                                             1.00                                                                              10.97            1DLC2075                    ATOM  1952                                                                              CD1                                                                               LEU 299                                                                               39.359                                                                             42.688                                                                             46.085                                                                             1.00                                                                              14.82            1DLC2076                    ATOM  1953                                                                              CD2                                                                               LEU 299                                                                               38.929                                                                             44.312                                                                             47.894                                                                             1.00                                                                              9.97             1DLC2077                    ATOM  1954                                                                              N  THR 300                                                                               37.291                                                                             40.943                                                                             51.455                                                                             1.00                                                                              19.12            1DLC2078                    ATOM  1955                                                                              CA THR 300                                                                               36.539                                                                             39.902                                                                             52.163                                                                             1.00                                                                              17.44            1DLC2079                    ATOM  1956                                                                              C  THR 300                                                                               35.105                                                                             39.598                                                                             51.710                                                                             1.00                                                                              20.09            1DLC2080                    ATOM  1957                                                                              O  THR 300                                                                               34.439                                                                             38.743                                                                             52.297                                                                             1.00                                                                              21.20            1DLC2081                    ATOM  1958                                                                              CB THR 300                                                                               36.492                                                                             40.200                                                                             53.680                                                                             1.00                                                                              18.14            1DLC2082                    ATOM  1959                                                                              OG1                                                                               THR 300                                                                               35.829                                                                             41.449                                                                             53.904                                                                             1.00                                                                              20.85            1DLC2083                    ATOM  1960                                                                              CG2                                                                               THR 300                                                                               37.899                                                                             40.264                                                                             54.270                                                                             1.00                                                                              17.00            1DLC2084                    ATOM  1961                                                                              N  ARG 301                                                                               34.631                                                                             40.268                                                                             50.667                                                                             1.00                                                                              20.53            1DLC2085                    ATOM  1962                                                                              CA ARG 301                                                                               33.259                                                                             40.074                                                                             50.184                                                                             1.00                                                                              18.35            1DLC2086                    ATOM  1963                                                                              C  ARG 301                                                                               32.963                                                                             38.762                                                                             49.451                                                                             1.00                                                                              19.18            1DLC2087                    ATOM  1964                                                                              O  ARG 301                                                                               33.850                                                                             38.158                                                                             48.849                                                                             1.00                                                                              18.71            1DLC2088                    ATOM  1965                                                                              CB ARG 301                                                                               32.842                                                                             41.248                                                                             49.291                                                                             1.00                                                                              13.09            1DLC2089                    ATOM  1966                                                                              CG ARG 301                                                                               33.280                                                                             41.126                                                                             47.830                                                                             1.00                                                                              13.61            1DLC2090                    ATOM  1967                                                                              CD ARG 301                                                                               34.792                                                                             41.044                                                                             47.678                                                                             1.00                                                                              14.65            1DLC2091                    ATOM  1968                                                                              NE ARG 301                                                                               35.197                                                                             40.844                                                                             46.291                                                                             1.00                                                                              14.20            1DLC2092                    ATOM  1969                                                                              CZ ARG 301                                                                               35.305                                                                             39.661                                                                             45.690                                                                             1.00                                                                              17.27            1DLC2093                    ATOM  1970                                                                              NH1                                                                               ARG 301                                                                               35.040                                                                             38.534                                                                             46.343                                                                             1.00                                                                              13.79            1DLC2094                    ATOM  1971                                                                              NH2                                                                               ARG 301                                                                               35.667                                                                             39.613                                                                             44.420                                                                             1.00                                                                              14.12            1DLC2095                    ATOM  1972                                                                              N  ASP 302                                                                               31.690                                                                             38.370                                                                             49.478                                                                             1.00                                                                              19.99            1DLC2096                    ATOM  1973                                                                              CA ASP 302                                                                               31.196                                                                             37.161                                                                             48.817                                                                             1.00                                                                              20.22            1DLC2097                    ATOM  1974                                                                              C  ASP 302                                                                               30.662                                                                             37.483                                                                             47.432                                                                             1.00                                                                              20.75            1DLC2098                    ATOM  1975                                                                              O  ASP 302                                                                               30.141                                                                             38.573                                                                             47.196                                                                             1.00                                                                              24.04            1DLC2099                    ATOM  1976                                                                              CB ASP 302                                                                               29.980                                                                             36.582                                                                             49.556                                                                             1.00                                                                              24.46            1DLC2100                    ATOM  1977                                                                              CG ASP 302                                                                               30.316                                                                             35.978                                                                             50.886                                                                             1.00                                                                              31.05            1DLC2101                    ATOM  1978                                                                              OD1                                                                               ASP 302                                                                               31.510                                                                             35.740                                                                             51.162                                                                             1.00                                                                              41.38            1DLC2102                    ATOM  1979                                                                              OD2                                                                               ASP 302                                                                               29.363                                                                             35.721                                                                             51.657                                                                             1.00                                                                              34.73            1DLC2103                    ATOM  1980                                                                              N  VAL 303                                                                               30.741                                                                             36.501                                                                             46.544                                                                             1.00                                                                              18.31            1DLC2104                    ATOM  1981                                                                              CA VAL 303                                                                               30.182                                                                             36.601                                                                             45.199                                                                             1.00                                                                              18.50            1DLC2105                    ATOM  1982                                                                              C  VAL 303                                                                               29.592                                                                             35.219                                                                             44.926                                                                             1.00                                                                              17.19            1DLC2106                    ATOM  1983                                                                              O  VAL 303                                                                               30.131                                                                             34.204                                                                             45.370                                                                             1.00                                                                              18.03            1DLC2107                    ATOM  1984                                                                              CB VAL 303                                                                               31.204                                                                             37.008                                                                             44.094                                                                             1.00                                                                              19.37            1DLC2108                    ATOM  1985                                                                              CG1                                                                               VAL 303                                                                               31.744                                                                             38.402                                                                             44.369                                                                             1.00                                                                              21.25            1DLC2109                    ATOM  1986                                                                              CG2                                                                               VAL 303                                                                               32.328                                                                             35.992                                                                             43.973                                                                             1.00                                                                              21.50            1DLC2110                    ATOM  1987                                                                              N  LEU 304                                                                               28.410                                                                             35.201                                                                             44.330                                                                             1.00                                                                              16.94            1DLC2111                    ATOM  1988                                                                              CA LEU 304                                                                               27.713                                                                             33.962                                                                             44.022                                                                             1.00                                                                              13.97            1DLC2112                    ATOM  1989                                                                              C  LEU 304                                                                               27.764                                                                             33.726                                                                             42.527                                                                             1.00                                                                              14.14            1DLC2113                    ATOM  1990                                                                              O  LEU 304                                                                               27.474                                                                             34.622                                                                             41.730                                                                             1.00                                                                              13.74            1DLC2114                    ATOM  1991                                                                              CB LEU 304                                                                               26.235                                                                             34.053                                                                             44.433                                                                             1.00                                                                              14.18            1DLC2115                    ATOM  1992                                                                              CG LEU 304                                                                               25.680                                                                             34.294                                                                             45.846                                                                             1.00                                                                              13.89            1DLC2116                    ATOM  1993                                                                              CD1                                                                               LEU 304                                                                               25.252                                                                             32.993                                                                             46.457                                                                             1.00                                                                              14.90            1DLC2117                    ATOM  1994                                                                              CD2                                                                               LEU 304                                                                               26.641                                                                             35.052                                                                             46.745                                                                             1.00                                                                              11.27            1DLC2118                    ATOM  1995                                                                              N  THR 305                                                                               28.146                                                                             32.521                                                                             42.140                                                                             1.00                                                                              14.38            1DLC2119                    ATOM  1996                                                                              CA THR 305                                                                               28.175                                                                             32.187                                                                             40.721                                                                             1.00                                                                              16.18            1DLC2120                    ATOM  1997                                                                              C  THR 305                                                                               26.737                                                                             31.864                                                                             40.282                                                                             1.00                                                                              17.39            1DLC2121                    ATOM  1998                                                                              O  THR 305                                                                               25.845                                                                             31.688                                                                             41.124                                                                             1.00                                                                              15.94            1DLC2122                    ATOM  1999                                                                              CB THR 305                                                                               29.115                                                                             30.969                                                                             40.422                                                                             1.00                                                                              17.34            1DLC2123                    ATOM  2000                                                                              OG1                                                                               THR 305                                                                               29.021                                                                             30.000                                                                             41.475                                                                             1.00                                                                              19.98            1DLC2124                    ATOM  2001                                                                              CG2                                                                               THR 305                                                                               30.565                                                                             31.415                                                                             40.270                                                                             1.00                                                                              18.26            1DLC2125                    ATOM  2002                                                                              N  ASP 306                                                                               26.488                                                                             31.891                                                                             38.978                                                                             1.00                                                                              15.04            1DLC2126                    ATOM  2003                                                                              CA ASP 306                                                                               25.177                                                                             31.551                                                                             38.437                                                                             1.00                                                                              17.79            1DLC2127                    ATOM  2004                                                                              C  ASP 306                                                                               24.785                                                                             30.157                                                                             38.913                                                                             1.00                                                                              21.19            1DLC2128                    ATOM  2005                                                                              O  ASP 306                                                                               25.651                                                                             29.278                                                                             39.067                                                                             1.00                                                                              24.55            1DLC2129                    ATOM  2006                                                                              CB ASP 306                                                                               25.222                                                                             31.530                                                                             36.912                                                                             1.00                                                                              15.07            1DLC2130                    ATOM  2007                                                                              CG ASP 306                                                                               25.286                                                                             32.905                                                                             36.310                                                                             1.00                                                                              15.88            1DLC2131                    ATOM  2008                                                                              OD1                                                                               ASP 306                                                                               24.822                                                                             33.867                                                                             36.946                                                                             1.00                                                                              18.05            1DLC2132                    ATOM  2009                                                                              OD2                                                                               ASP 306                                                                               25.777                                                                             33.024                                                                             35.174                                                                             1.00                                                                              23.36            1DLC2133                    ATOM  2010                                                                              N  PRO 307                                                                               23.483                                                                             29.938                                                                             39.179                                                                             1.00                                                                              22.83            1DLC2134                    ATOM  2011                                                                              CA PRO 307                                                                               23.004                                                                             28.623                                                                             39.639                                                                             1.00                                                                              20.21            1DLC2135                    ATOM  2012                                                                              C  PRO 307                                                                               23.289                                                                             27.551                                                                             38.587                                                                             1.00                                                                              16.74            1DLC2136                    ATOM  2013                                                                              O  PRO 307                                                                               23.289                                                                             27.827                                                                             37.389                                                                             1.00                                                                              17.78            1DLC2137                    ATOM  2014                                                                              CB PRO 307                                                                               21.502                                                                             28.848                                                                             39.811                                                                             1.00                                                                              20.31            1DLC2138                    ATOM  2015                                                                              CG PRO 307                                                                               21.410                                                                             30.306                                                                             40.150                                                                             1.00                                                                              21.80            1DLC2139                    ATOM  2016                                                                              CD PRO 307                                                                               22.388                                                                             30.925                                                                             39.175                                                                             1.00                                                                              20.89            1DLC2140                    ATOM  2017                                                                              N  ILE 308                                                                               23.547                                                                             26.333                                                                             39.033                                                                             1.00                                                                              18.04            1DLC2141                    ATOM  2018                                                                              CA ILE 308                                                                               23.851                                                                             25.245                                                                             38.107                                                                             1.00                                                                              19.10            1DLC2142                    ATOM  2019                                                                              C  ILE 308                                                                               22.579                                                                             24.514                                                                             37.684                                                                             1.00                                                                              21.11            1DLC2143                    ATOM  2020                                                                              O  ILE 308                                                                               22.004                                                                             23.759                                                                             38.473                                                                             1.00                                                                              23.40            1DLC2144                    ATOM  2021                                                                              CB ILE 308                                                                               24.833                                                                             24.227                                                                             38.753                                                                             1.00                                                                              20.63            1DLC2145                    ATOM  2022                                                                              CG1                                                                               ILE 308                                                                               25.992                                                                             24.971                                                                             39.439                                                                             1.00                                                                              21.46            1DLC2146                    ATOM  2023                                                                              CG2                                                                               ILE 308                                                                               25.352                                                                             23.252                                                                             37.700                                                                             1.00                                                                              19.02            1DLC2147                    ATOM  2024                                                                              CD1                                                                               ILE 308                                                                               26.923                                                                             24.082                                                                             40.247                                                                             1.00                                                                              17.99            1DLC2148                    ATOM  2025                                                                              N  VAL 309                                                                               22.119                                                                             24.763                                                                             36.460                                                                             1.00                                                                              23.15            1DLC2149                    ATOM  2026                                                                              CA VAL 309                                                                               20.907                                                                             24.108                                                                             35.944                                                                             1.00                                                                              25.59            1DLC2150                    ATOM  2027                                                                              C  VAL 309                                                                               21.139                                                                             23.415                                                                             34.602                                                                             1.00                                                                              25.03            1DLC2151                    ATOM  2028                                                                              O  VAL 309                                                                               21.908                                                                             23.891                                                                             33.778                                                                             1.00                                                                              24.20            1DLC2152                    ATOM  2029                                                                              CB VAL 309                                                                               19.689                                                                             25.093                                                                             35.800                                                                             1.00                                                                              23.31            1DLC2153                    ATOM  2030                                                                              CG1                                                                               VAL 309                                                                               19.295                                                                             25.652                                                                             37.160                                                                             1.00                                                                              24.72            1DLC2154                    ATOM  2031                                                                              CG2                                                                               VAL 309                                                                               20.005                                                                             26.214                                                                             34.847                                                                             1.00                                                                              25.99            1DLC2155                    ATOM  2032                                                                              N  GLY 310                                                                               20.462                                                                             22.290                                                                             34.393                                                                             1.00                                                                              26.11            1DLC2156                    ATOM  2033                                                                              CA GLY 310                                                                               20.610                                                                             21.549                                                                             33.151                                                                             1.00                                                                              28.39            1DLC2157                    ATOM  2034                                                                              C  GLY 310                                                                               19.889                                                                             22.100                                                                             31.926                                                                             1.00                                                                              31.24            1DLC2158                    ATOM  2035                                                                              O  GLY 310                                                                               20.257                                                                             21.777                                                                             30.802                                                                             1.00                                                                              35.55            1DLC2159                    ATOM  2036                                                                              N  GLY 310                                                                               18.866                                                                             22.927                                                                             32.128                                                                             1.00                                                                              32.38            1DLC2160                    ATOM  2037                                                                              CA VAL 311                                                                               18.102                                                                             23.498                                                                             31.012                                                                             1.00                                                                              30.87            1DLC2161                    ATOM  2038                                                                              C  VAL 311                                                                               18.111                                                                             25.024                                                                             31.105                                                                             1.00                                                                              29.77            1DLC2162                    ATOM  2039                                                                              O  VAL 311                                                                               18.175                                                                             25.648                                                                             32.070                                                                             1.00                                                                              31.01            1DLC2163                    ATOM  2040                                                                              CB VAL 311                                                                               16.616                                                                             23.022                                                                             31.028                                                                             1.00                                                                              31.20            1DLC2164                    ATOM  2041                                                                              CG1                                                                               VAL 311                                                                               16.525                                                                             21.524                                                                             30.803                                                                             1.00                                                                              32.24            1DLC2165                    ATOM  2042                                                                              CG2                                                                               VAL 311                                                                               15.966                                                                             23.374                                                                             32.347                                                                             1.00                                                                              28.27            1DLC2166                    ATOM  2043                                                                              N  ASN 312                                                                               17.976                                                                             25.613                                                                             29.832                                                                             1.00                                                                              34.45            1DLC2167                    ATOM  2044                                                                              CA ASN 312                                                                               17.968                                                                             27.071                                                                             29.683                                                                             1.00                                                                              38.67            1DLC2168                    ATOM  2045                                                                              C  ASN 312                                                                               16.678                                                                             27.741                                                                             30.145                                                                             1.00                                                                              37.69            1DLC2169                    ATOM  2046                                                                              O  ASN 312                                                                               16.696                                                                             28.874                                                                             30.619                                                                             1.00                                                                              39.59            1DLC2170                    ATOM  2047                                                                              CB ASN 312                                                                               18.219                                                                             27.462                                                                             28.225                                                                             1.00                                                                              46.17            1DLC2171                    ATOM  2048                                                                              CG ASN 312                                                                               19.670                                                                             27.287                                                                             27.806                                                                             1.00                                                                              53.31            1DLC2172                    ATOM  2049                                                                              OD1                                                                               ASN 312                                                                               20.581                                                                             27.275                                                                             28.638                                                                             1.00                                                                              56.28            1DLC2173                    ATOM  2050                                                                              ND2                                                                               ASN 312                                                                               19.894                                                                             27.181                                                                             26.500                                                                             1.00                                                                              59.74            1DLC2174                    ATOM  2051                                                                              N  ASN 313                                                                               15.559                                                                             27.048                                                                             29.963                                                                             1.00                                                                              35.04            1DLC2175                    ATOM  2052                                                                              CA ASN 313                                                                               14.243                                                                             27.559                                                                             30.339                                                                             1.00                                                                              31.97            1DLC2176                    ATOM  2053                                                                              C  ASN 313                                                                               13.538                                                                             26.549                                                                             31.247                                                                             1.00                                                                              30.91            1DLC2177                    ATOM  2054                                                                              O  ASN 313                                                                               13.221                                                                             25.432                                                                             30.819                                                                             1.00                                                                              32.94            1DLC2178                    ATOM  2055                                                                              CB ASN 313                                                                               13.427                                                                             27.807                                                                             29.065                                                                             1.00                                                                              31.98            1DLC2179                    ATOM  2056                                                                              CG ASN 313                                                                               12.051                                                                             28.364                                                                             29.339                                                                             1.00                                                                              29.11            1DLC2180                    ATOM  2057                                                                              OD1                                                                               ASN 313                                                                               11.646                                                                             28.542                                                                             30.486                                                                             1.00                                                                              31.35            1DLC2181                    ATOM  2058                                                                              ND2                                                                               ASN 313                                                                               11.322                                                                             28.651                                                                             28.279                                                                             1.00                                                                              26.80            1DLC2182                    ATOM  2059                                                                              N  LEU 314                                                                               13.295                                                                             26.950                                                                             32.493                                                                             1.00                                                                              26.72            1DLC2183                    ATOM  2060                                                                              CA LEU 314                                                                               12.648                                                                             26.991                                                                             33.486                                                                             1.00                                                                              24.82            1DLC2184                    ATOM  2061                                                                              C  LEU 314                                                                               11.114                                                                             26.096                                                                             33.478                                                                             1.00                                                                              26.88            1DLC2185                    ATOM  2062                                                                              O  LEU 314                                                                               10.483                                                                             25.503                                                                             34.363                                                                             1.00                                                                              29.59            1DLC2186                    ATOM  2063                                                                              CB LEU 314                                                                               13.151                                                                             26.432                                                                             34.891                                                                             1.00                                                                              21.60            1DLC2187                    ATOM  2064                                                                              CG LEU 314                                                                               14.519                                                                             25.889                                                                             35.295                                                                             1.00                                                                              22.09            1DLC2188                    ATOM  2065                                                                              CD1                                                                               LEU 314                                                                               14.849                                                                             26.325                                                                             36.707                                                                             1.00                                                                              20.63            1DLC2189                    ATOM  2066                                                                              CD2                                                                               LEU 314                                                                               14.510                                                                             24.373                                                                             35.217                                                                             1.00                                                                              20.55            1DLC2190                    ATOM  2067                                                                              N  ARG 315                                                                               10.525                                                                             26.768                                                                             32.491                                                                             1.00                                                                              24.99            1DLC2191                    ATOM  2068                                                                              CA ARG 315                                                                               9.072                                                                              26.865                                                                             32.353                                                                             1.00                                                                              24.53            1DLC2192                    ATOM  2069                                                                              C  ARG 315                                                                               8.306                                                                              27.125                                                                             33.659                                                                             1.00                                                                              21.66            1DLC2193                    ATOM  2070                                                                              O  ARG 315                                                                               7.305                                                                              26.478                                                                             33.947                                                                             1.00                                                                              25.12            1DLC2194                    ATOM  2071                                                                              CB ARG 315                                                                               8.508                                                                              25.640                                                                             31.619                                                                             1.00                                                                              28.28            1DLC2195                    ATOM  2072                                                                              CG ARG 315                                                                               8.737                                                                              25.652                                                                             30.105                                                                             1.00                                                                              34.47            1DLC2196                    ATOM  2073                                                                              CD ARG 315                                                                               7.977                                                                              24.524                                                                             29.387                                                                             1.00                                                                              45.54            1DLC2197                    ATOM  2074                                                                              NE ARG 315                                                                               6.513                                                                              24.685                                                                             29.412                                                                             1.00                                                                              59.49            1DLC2198                    ATOM  2075                                                                              CZ ARG 315                                                                               5.682                                                                              24.048                                                                             30.246                                                                             1.00                                                                              63.23            1DLC2199                    ATOM  2076                                                                              NH1                                                                               ARG 315                                                                               6.149                                                                              23.191                                                                             31.149                                                                             1.00                                                                              65.85            1DLC2200                    ATOM  2077                                                                              NH2                                                                               ARG 315                                                                               4.373                                                                              24.264                                                                             30.179                                                                             1.00                                                                              62.27            1DLC2201                    ATOM  2078                                                                              N  GLY 316                                                                               8.807                                                                              28.060                                                                             34.458                                                                             1.00                                                                              21.30            1DLC2202                    ATOM  2079                                                                              CA GLY 316                                                                               8.151                                                                              28.420                                                                             35.704                                                                             1.00                                                                              16.98            1DLC2203                    ATOM  2080                                                                              C  GLY 316                                                                               8.497                                                                              27.638                                                                             36.953                                                                             1.00                                                                              18.35            1DLC2204                    ATOM  2081                                                                              O  GLY 316                                                                               8.082                                                                              28.010                                                                             38.049                                                                             1.00                                                                              17.47            1DLC2205                    ATOM  2082                                                                              N  TYR 317                                                                               9.256                                                                              26.561                                                                             36.812                                                                             1.00                                                                              20.77            1DLC2206                    ATOM  2083                                                                              CA TYR 317                                                                               9.615                                                                              25.751                                                                             37.971                                                                             1.00                                                                              20.18            1DLC2207                    ATOM  2084                                                                              C  TYR 317                                                                               10.806                                                                             26.243                                                                             38.782                                                                             1.00                                                                              21.76            1DLC2208                    ATOM  2085                                                                              O  TYR 317                                                                               11.103                                                                             25.704                                                                             39.847                                                                             1.00                                                                              24.15            1DLC2209                    ATOM  2086                                                                              CB TYR 317                                                                               9.800                                                                              24.298                                                                             37.554                                                                             1.00                                                                              22.63            1DLC2210                    ATOM  2087                                                                              CG TYR 317                                                                               8.497                                                                              23.648                                                                             37.192                                                                             1.00                                                                              23.66            1DLC2211                    ATOM  2088                                                                              CD1                                                                               TYR 317                                                                               7.703                                                                              23.062                                                                             38.171                                                                             1.00                                                                              25.39            1DLC2212                    ATOM  2089                                                                              CD2                                                                               TYR 317                                                                               8.027                                                                              23.668                                                                             35.882                                                                             1.00                                                                              24.11            1DLC2213                    ATOM  2090                                                                              CE1                                                                               TYR 317                                                                               6.469                                                                              22.512                                                                             37.860                                                                             1.00                                                                              27.42            1DLC2214                    ATOM  2091                                                                              CE2                                                                               TYR 317                                                                               6.795                                                                              23.127                                                                             35.557                                                                             1.00                                                                              27.40            1DLC2215                    ATOM  2092                                                                              CZ TYR 317                                                                               6.018                                                                              22.551                                                                             36.557                                                                             1.00                                                                              29.75            1DLC2216                    ATOM  2093                                                                              OH TYR 317                                                                               4.782                                                                              22.026                                                                             36.262                                                                             1.00                                                                              34.32            1DLC2217                    ATOM  2094                                                                              N  GLY 318                                                                               11.475                                                                             27.281                                                                             38.300                                                                             1.00                                                                              20.77            1DLC2218                    ATOM  2095                                                                              CA GLY 318                                                                               12.608                                                                             27.810                                                                             39.029                                                                             1.00                                                                              18.55            1DLC2219                    ATOM  2096                                                                              C  GLY 318                                                                               12.210                                                                             28.393                                                                             40.374                                                                             1.00                                                                              19.44            1DLC2220                    ATOM  2097                                                                              O  GLY 318                                                                               11.130                                                                             28.977                                                                             40.519                                                                             1.00                                                                              20.54            1DLC2221                    ATOM  2098                                                                              N  THR 319                                                                               13.069                                                                             28.209                                                                             41.369                                                                             1.00                                                                              17.62            1DLC2222                    ATOM  2099                                                                              CA THR 319                                                                               12.834                                                                             28.739                                                                             42.712                                                                             1.00                                                                              17.45            1DLC2223                    ATOM  2100                                                                              C  THR 319                                                                               12.556                                                                             30.236                                                                             42.630                                                                             1.00                                                                              20.62            1DLC2224                    ATOM  2101                                                                              O  THR 319                                                                               13.184                                                                             30.941                                                                             41.842                                                                             1.00                                                                              25.06            1DLC2225                    ATOM  2102                                                                              CB THR 319                                                                               14.075                                                                             28.548                                                                             43.573                                                                             1.00                                                                              17.42            1DLC2226                    ATOM  2103                                                                              OG1                                                                               THR 319                                                                               14.492                                                                             27.180                                                                             43.496                                                                             1.00                                                                              21.15            1DLC2227                    ATOM  2104                                                                              CG2                                                                               THR 319                                                                               13.794                                                                             28.924                                                                             45.012                                                                             1.00                                                                              14.83            1DLC2228                    ATOM  2105                                                                              N  THR 320                                                                               11.631                                                                             30.732                                                                             43.440                                                                             1.00                                                                              19.91            1DLC2229                    ATOM  2106                                                                              CA THR 320                                                                               11.307                                                                             32.157                                                                             43.398                                                                             1.00                                                                              18.68            1DLC2230                    ATOM  2107                                                                              C  THR 320                                                                               12.414                                                                             33.064                                                                             43.936                                                                             1.00                                                                              20.02            1DLC2231                    ATOM  2108                                                                              O  THR 320                                                                               13.210                                                                             32.666                                                                             44.790                                                                             1.00                                                                              24.12            1DLC2232                    ATOM  2109                                                                              CB THR 320                                                                               9.997                                                                              32.468                                                                             44.141                                                                             1.00                                                                              16.01            1DLC2233                    ATOM  2110                                                                              OG1                                                                               THR 320                                                                               10.095                                                                             32.022                                                                             45.493                                                                             1.00                                                                              19.03            1DLC2234                    ATOM  2111                                                                              CG2                                                                               THR 320                                                                               8.848                                                                              31.775                                                                             43.477                                                                             1.00                                                                              10.83            1DLC2235                    ATOM  2112                                                                              N  PHE 321                                                                               12.446                                                                             34.291                                                                             43.431                                                                             1.00                                                                              18.76            1DLC2236                    ATOM  2113                                                                              CA PHE 321                                                                               13.430                                                                             35.292                                                                             43.835                                                                             1.00                                                                              18.42            1DLC2237                    ATOM  2114                                                                              C  PHE 321                                                                               13.600                                                                             35.328                                                                             45.359                                                                             1.00                                                                              19.97            1DLC2238                    ATOM  2115                                                                              O  PHE 321                                                                               14.700                                                                             35.142                                                                             45.882                                                                             1.00                                                                              18.92            1DLC2239                    ATOM  2116                                                                              CB PHE 321                                                                               12.990                                                                             36.666                                                                             43.311                                                                             1.00                                                                              18.89            1DLC2240                    ATOM  2117                                                                              CG PHE 321                                                                               14.009                                                                             37.758                                                                             43.500                                                                             1.00                                                                              20.25            1DLC2241                    ATOM  2118                                                                              CD1                                                                               PHE 321                                                                               14.366                                                                             38.199                                                                             44.776                                                                             1.00                                                                              19.19            1DLC2242                    ATOM  2119                                                                              CD2                                                                               PHE 321                                                                               14.589                                                                             38.373                                                                             42.398                                                                             1.00                                                                              18.51            1DLC2243                    ATOM  2120                                                                              CE1                                                                               PHE 321                                                                               15.279                                                                             39.235                                                                             44.947                                                                             1.00                                                                              20.39            1DLC2244                    ATOM  2121                                                                              qE2                                                                               PHE 321                                                                               15.504                                                                             39.412                                                                             42.560                                                                             1.00                                                                              19.17            1DLC2245                    ATOM  2122                                                                              CZ PHE 321                                                                               15.849                                                                             39.844                                                                             43.835                                                                             1.00                                                                              21.01            1DLC2246                    ATOM  2123                                                                              N  SER 322                                                                               12.497                                                                             35.528                                                                             46.069                                                                             1.00                                                                              21.66            1DLC2247                    ATOM  2124                                                                              CA SER 322                                                                               12.527                                                                             35.587                                                                             47.531                                                                             1.00                                                                              23.88            1DLC2248                    ATOM  2125                                                                              C  SER 322                                                                               12.978                                                                             34.310                                                                             48.220                                                                             1.00                                                                              21.84            1DLC2249                    ATOM  2126                                                                              O  SER 322                                                                               13.594                                                                             34.361                                                                             49.283                                                                             1.00                                                                              23.06            1DLC2250                    ATOM  2127                                                                              CB SER 322                                                                               11.176                                                                             36.030                                                                             48.079                                                                             1.00                                                                              24.50            1DLC2251                    ATOM  2128                                                                              OG SER 322                                                                               10.894                                                                             37.344                                                                             47.621                                                                             1.00                                                                              37.62            1DLC2252                    ATOM  2129                                                                              N  ASN 323                                                                               12.695                                                                             33.163                                                                             47.614                                                                             1.00                                                                              22.20            1DLC2253                    ATOM  2130                                                                              CA ASN 323                                                                               13.117                                                                             31.900                                                                             48.208                                                                             1.00                                                                              23.04            1DLC2254                    ATOM  2131                                                                              C  ASN 323                                                                               14.606                                                                             31.623                                                                             48.007                                                                             1.00                                                                              21.38            1DLC2255                    ATOM  2132                                                                              O  ASN 323                                                                               15.159                                                                             30.688                                                                             48.582                                                                             1.00                                                                              22.81            1DLC2256                    ATOM  2133                                                                              CB ASN 323                                                                               12.250                                                                             30.743                                                                             47.732                                                                             1.00                                                                              24.92            1DLC2257                    ATOM  2134                                                                              CG ASN 323                                                                               10.897                                                                             30.730                                                                             48.408                                                                             1.00                                                                              25.16            1DLC2258                    ATOM  2135                                                                              OD1                                                                               ASN 323                                                                               10.741                                                                             31.216                                                                             49.525                                                                             1.00                                                                              26.34            1DLC2259                    ATOM  2136                                                                              ND2                                                                               ASN 323                                                                               9.909                                                                              30.193                                                                             47.727                                                                             1.00                                                                              29.75            1DLC2260                    ATOM  2137                                                                              N  ILE 324                                                                               15.240                                                                             32.426                                                                             47.160                                                                             1.00                                                                              19.13            1DLC2261                    ATOM  2138                                                                              CA ILE 324                                                                               16.672                                                                             32.318                                                                             46.961                                                                             1.00                                                                              17.26            1DLC2262                    ATOM  2139                                                                              C  ILE 324                                                                               17.340                                                                             33.454                                                                             47.759                                                                             1.00                                                                              18.23            1DLC2263                    ATOM  2140                                                                              O  ILE 324                                                                               18.050                                                                             33.214                                                                             48.742                                                                             1.00                                                                              18.12            1DLC2264                    ATOM  2141                                                                              CB ILE 324                                                                               17.073                                                                             32.449                                                                             45.485                                                                             1.00                                                                              13.05            1DLC2265                    ATOM  2142                                                                              CG1                                                                               ILE 324                                                                               16.380                                                                             31.379                                                                             44.655                                                                             1.00                                                                              10.69            1DLC2266                    ATOM  2143                                                                              CG2                                                                               ILE 324                                                                               18.584                                                                             32.294                                                                             45.342                                                                             1.00                                                                              13.12            1DLC2267                    ATOM  2144                                                                              CD1                                                                               ILE 324                                                                               16.771                                                                             31.402                                                                             43.202                                                                             1.00                                                                              11.56            1DLC2268                    ATOM  2145                                                                              N  GLU 325                                                                               17.014                                                                             34.693                                                                             47.399                                                                             1.00                                                                              17.70            1DLC2269                    ATOM  2146                                                                              CA GLU 325                                                                               17.608                                                                             35.866                                                                             48.038                                                                             1.00                                                                              19.04            1DLC2270                    ATOM  2147                                                                              C  GLU 325                                                                               17.473                                                                             35.948                                                                             49.560                                                                             1.00                                                                              21.70            1DLC2271                    ATOM  2148                                                                              O  GLU 325                                                                               18.416                                                                             36.347                                                                             50.242                                                                             1.00                                                                              23.28            1DLC2272                    ATOM  2149                                                                              CB GLU 325                                                                               17.117                                                                             37.149                                                                             47.356                                                                             1.00                                                                              20.14            1DLC2273                    ATOM  2150                                                                              CG GLU 325                                                                               17.856                                                                             38.439                                                                             47.749                                                                             1.00                                                                              19.56            1DLC2274                    ATOM  2151                                                                              CD GLU 325                                                                               19.369                                                                             38.422                                                                             47.477                                                                             1.00                                                                              19.74            1DLC2275                    ATOM  2152                                                                              OE1                                                                               GLU 325                                                                               19.836                                                                             37.805                                                                             46.497                                                                             1.00                                                                              19.17            1DLC2276                    ATOM  2153                                                                              OE2                                                                               GLU 325                                                                               20.104                                                                             39.056                                                                             48.259                                                                             1.00                                                                              21.56            1DLC2277                    ATOM  2154                                                                              N  ASN 326                                                                               16.333                                                                             35.529                                                                             50.100                                                                             1.00                                                                              22.82            1DLC2278                    ATOM  2155                                                                              CA ASN 326                                                                               16.133                                                                             35.568                                                                             51.546                                                                             1.00                                                                              21.61            1DLC2279                    ATOM  2156                                                                              C  ASN 326                                                                               16.849                                                                             34.441                                                                             52.271                                                                             1.00                                                                              22.46            1DLC2280                    ATOM  2157                                                                              O  ASN 326                                                                               16.948                                                                             34.449                                                                             53.499                                                                             1.00                                                                              22.03            1DLC2281                    ATOM  2158                                                                              CB ASN 326                                                                               14.646                                                                             35.512                                                                             51.891                                                                             1.00                                                                              25.83            1DLC2282                    ATOM  2159                                                                              CG ASN 326                                                                               13.912                                                                             36.795                                                                             51.551                                                                             1.00                                                                              30.73            1DLC2283                    ATOM  2160                                                                              OD1                                                                               ASN 326                                                                               12.713                                                                             36.784                                                                             51.298                                                                             1.00                                                                              36.78            1DLC2284                    ATOM  2161                                                                              ND2                                                                               ASN 326                                                                               14.621                                                                             37.907                                                                             51.556                                                                             1.00                                                                              33.22            1DLC2285                    ATOM  2162                                                                              N  TYR 327                                                                               17.346                                                                             33.469                                                                             51.515                                                                             1.00                                                                              21.89            1DLC2286                    ATOM  2163                                                                              CA TYR 327                                                                               18.023                                                                             32.335                                                                             52.128                                                                             1.00                                                                              23.83            1DLC2287                    ATOM  2164                                                                              C  TYR 327                                                                               19.516                                                                             32.203                                                                             51.912                                                                             1.00                                                                              22.96            1DLC2288                    ATOM  2165                                                                              O  TYR 327                                                                               20.148                                                                             31.355                                                                             52.533                                                                             1.00                                                                              27.36            1DLC2289                    ATOM  2166                                                                              CB TYR 327                                                                               17.313                                                                             31.034                                                                             51.773                                                                             1.00                                                                              30.00            1DLC2290                    ATOM  2167                                                                              CG TYR 327                                                                               15.943                                                                             30.955                                                                             52.399                                                                             1.00                                                                              33.84            1DLC2291                    ATOM  2168                                                                              CD1                                                                               TYR 327                                                                               14.835                                                                             31.495                                                                             51.755                                                                             1.00                                                                              32.53            1DLC2292                    ATOM  2169                                                                              CD2                                                                               TYR 327                                                                               15.761                                                                             30.363                                                                             53.648                                                                             1.00                                                                              34.52            1DLC2293                    ATOM  2170                                                                              CE1                                                                               TYR 327                                                                               13.589                                                                             31.452                                                                             52.333                                                                             1.00                                                                              36.59            1DLC2294                    ATOM  2171                                                                              CE2                                                                               TYR 327                                                                               14.511                                                                             30.313                                                                             54.239                                                                             1.00                                                                              36.84            1DLC2295                    ATOM  2172                                                                              CZ TYR 327                                                                               13.427                                                                             30.859                                                                             53.574                                                                             1.00                                                                              39.48            1DLC2296                    ATOM  2173                                                                              OH TYR 327                                                                               12.167                                                                             30.805                                                                             54.138                                                                             1.00                                                                              48.47            1DLC2297                    ATOM  2174                                                                              N  ILE 328                                                                               20.085                                                                             33.005                                                                             51.020                                                                             1.00                                                                              20.63            1DLC2298                    ATOM  2175                                                                              CA ILE 328                                                                               21.525                                                                             32.955                                                                             50.813                                                                             1.00                                                                              19.45            1DLC2299                    ATOM  2176                                                                              C  ILE 328                                                                               22.176                                                                             33.473                                                                             52.102                                                                             1.00                                                                              23.48            1DLC2300                    ATOM  2177                                                                              O  ILE 328                                                                               21.511                                                                             34.124                                                                             52.919                                                                             1.00                                                                              24.83            1DLC2301                    ATOM  2178                                                                              CB ILE 328                                                                               21.977                                                                             33.815                                                                             49.610                                                                             1.00                                                                              17.68            1DLC2302                    ATOM  2179                                                                              CG1                                                                               ILE 328                                                                               21.666                                                                             35.292                                                                             49.842                                                                             1.00                                                                              19.52            1DLC2303                    ATOM  2180                                                                              CG2                                                                               ILE 328                                                                               21.308                                                                             33.332                                                                             48.348                                                                             1.00                                                                              15.95            1DLC2304                    ATOM  2181                                                                              CD1                                                                               ILE 328                                                                               22.220                                                                             36.207                                                                             48.778                                                                             1.00                                                                              18.88            1DLC2305                    ATOM  2182                                                                              N  ARG 329                                                                               23.457                                                                             33.161                                                                             52.296                                                                             1.00                                                                              24.81            1DLC2306                    ATOM  2183                                                                              CA ARG 329                                                                               24.207                                                                             33.576                                                                             53.486                                                                             1.00                                                                              21.84            1DLC2307                    ATOM  2184                                                                              C  ARG 329                                                                               24.091                                                                             35.065                                                                             53.820                                                                             1.00                                                                              22.27            1DLC2308                    ATOM  2185                                                                              O  ARG 329                                                                               24.268                                                                             35.917                                                                             52.953                                                                             1.00                                                                              25.04            1DLC2309                    ATOM  2186                                                                              CB ARG 329                                                                               25.683                                                                             33.242                                                                             53.299                                                                             1.00                                                                              23.15            1DLC2310                    ATOM  2187                                                                              CG ARG 329                                                                               25.990                                                                             31.776                                                                             53.243                                                                             1.00                                                                              24.82            1DLC2311                    ATOM  2188                                                                              CD ARG 329                                                                               26.732                                                                             31.373                                                                             54.501                                                                             1.00                                                                              28.71            1DLC2312                    ATOM  2189                                                                              NE ARG 329                                                                               28.173                                                                             31.390                                                                             54.297                                                                             1.00                                                                              24.15            1DLC2313                    ATOM  2190                                                                              CZ ARG 329                                                                               29.077                                                                             31.204                                                                             55.256                                                                             1.00                                                                              23.69            1DLC2314                    ATOM  2191                                                                              NH1                                                                               ARG 329                                                                               28.710                                                                             30.996                                                                             56.515                                                                             1.00                                                                              13.74            1DLC2315                    ATOM  2192                                                                              NH2                                                                               ARG 329                                                                               30.360                                                                             31.179                                                                             54.937                                                                             1.00                                                                              20.55            1DLC2316                    ATOM  2193                                                                              N  LYS 330                                                                               23.804                                                                             35.373                                                                             55.080                                                                             1.00                                                                              24.03            1DLC2317                    ATOM  2194                                                                              CA LYS 330                                                                               23.696                                                                             36.763                                                                             55.533                                                                             1.00                                                                              24.69            1DLC2318                    ATOM  2195                                                                              C  LYS 330                                                                               25.041                                                                             37.243                                                                             56.085                                                                             1.00                                                                              22.84            1DLC2319                    ATOM  2196                                                                              O  LYS 330                                                                               25.929                                                                             36.428                                                                             56.345                                                                             1.00                                                                              22.64            1DLC2320                    ATOM  2197                                                                              CB LYS 330                                                                               22.608                                                                             36.896                                                                             56.605                                                                             1.00                                                                              27.12            1DLC2321                    ATOM  2198                                                                              CG LYS 330                                                                               21.199                                                                             36.885                                                                             56.033                                                                             1.00                                                                              33.76            1DLC2322                    ATOM  2199                                                                              CD LYS 330                                                                               20.164                                                                             37.200                                                                             57.096                                                                             1.00                                                                              42.42            1DLC2323                    ATOM  2200                                                                              CE LYS 330                                                                               18.753                                                                             37.179                                                                             56.510                                                                             1.00                                                                              47.90            1DLC2324                    ATOM  2201                                                                              NZ LYS 330                                                                               18.405                                                                             35.828                                                                             55.959                                                                             1.00                                                                              53.46            1DLC2325                    ATOM  2202                                                                              N  PRO 331                                                                               25.219                                                                             38.568                                                                             56.245                                                                             1.00                                                                              22.24            1DLC2326                    ATOM  2203                                                                              CA PRO 331                                                                               26.479                                                                             39.105                                                                             56.771                                                                             1.00                                                                              20.54            1DLC2327                    ATOM  2204                                                                              C  PRO 331                                                                               27.000                                                                             38.248                                                                             57.913                                                                             1.00                                                                              21.52            1DLC2328                    ATOM  2205                                                                              O  PRO 331                                                                               26.327                                                                             38.053                                                                             58.918                                                                             1.00                                                                              23.22            1DLC2329                    ATOM  2206                                                                              CB PRO 331                                                                               26.079                                                                             40.497                                                                             57.230                                                                             1.00                                                                              21.52            1DLC2330                    ATOM  2207                                                                              CG PRO 331                                                                               25.100                                                                             40.898                                                                             56.163                                                                             1.00                                                                              19.00            1DLC2331                    ATOM  2208                                                                              CD PRO 331                                                                               24.252                                                                             39.654                                                                             55.996                                                                             1.00                                                                              19.95            1DLC2332                    ATOM  2209                                                                              N  HIS 332                                                                               28.193                                                                             37.700                                                                             57.715                                                                             1.00                                                                              21.33            1DLC2333                    ATOM  2210                                                                              CA HIS 332                                                                               28.810                                                                             36.810                                                                             58.682                                                                             1.00                                                                              18.59            1DLC2334                    ATOM  2211                                                                              C  HIS 332                                                                               30.310                                                                             37.019                                                                             58.847                                                                             1.00                                                                              19.87            1DLC2335                    ATOM  2212                                                                              O  HIS 332                                                                               30.991                                                                             37.511                                                                             57.949                                                                             1.00                                                                              19.56            1DLC2336                    ATOM  2213                                                                              CB HIS 332                                                                               28.597                                                                             35.371                                                                             58.214                                                                             1.00                                                                              14.92            1DLC2337                    ATOM  2214                                                                              CG HIS 332                                                                               29.196                                                                             35.084                                                                             56.870                                                                             1.00                                                                              13.36            1DLC2338                    ATOM  2215                                                                              ND1                                                                               HIS 332                                                                               30.474                                                                             34.589                                                                             56.712                                                                             1.00                                                                              17.22            1DLC2339                    ATOM  2216                                                                              CD2                                                                               HIS 332                                                                               28.700                                                                             35.242                                                                             55.619                                                                             1.00                                                                              13.52            1DLC2340                    ATOM  2217                                                                              CE1                                                                               HIS 332                                                                               30.741                                                                             34.454                                                                             55.425                                                                             1.00                                                                              16.38            1DLC2341                    ATOM  2218                                                                              NE2                                                                               HIS 332                                                                               29.680                                                                             34.843                                                                             54.740                                                                             1.00                                                                              18.37            1DLC2342                    ATOM  2219                                                                              N  LEU 333                                                                               30.828                                                                             36.585                                                                             59.987                                                                             1.00                                                                              20.07            1DLC2343                    ATOM  2220                                                                              CA LEU 333                                                                               32.260                                                                             36.643                                                                             60.259                                                                             1.00                                                                              17.84            1DLC2344                    ATOM  2221                                                                              C  LEU 333                                                                               32.883                                                                             35.741                                                                             59.180                                                                             1.00                                                                              18.07            1DLC2345                    ATOM  2222                                                                              O  LEU 333                                                                               32.246                                                                             34.784                                                                             58.719                                                                             1.00                                                                              19.71            1DLC2346                    ATOM  2223                                                                              CB LEU 333                                                                               32.518                                                                             36.070                                                                             61.651                                                                             1.00                                                                              12.65            1DLC2347                    ATOM  2224                                                                              CG LEU 333                                                                               33.158                                                                             36.944                                                                             62.721                                                                             1.00                                                                              14.26            1DLC2348                    ATOM  2225                                                                              CD1                                                                               LEU 333                                                                               32.855                                                                             38.403                                                                             62.506                                                                             1.00                                                                              13.22            1DLC2349                    ATOM  2226                                                                              CD2                                                                               LEU 333                                                                               32.689                                                                             36.472                                                                             64.083                                                                             1.00                                                                              9.06             1DLC2350                    ATOM  2227                                                                              N  PHE 334                                                                               34.089                                                                             36.065                                                                             58.738                                                                             1.00                                                                              16.81            1DLC2351                    ATOM  2228                                                                              CA PHE 334                                                                               34.756                                                                             35.294                                                                             57.689                                                                             1.00                                                                              16.45            1DLC2352                    ATOM  2229                                                                              C  PHE 334                                                                               35.055                                                                             33.841                                                                             58.074                                                                             1.00                                                                              18.71            1DLC2353                    ATOM  2230                                                                              O  PHE 334                                                                               35.438                                                                             33.562                                                                             59.217                                                                             1.00                                                                              21.26            1DLC2354                    ATOM  2231                                                                              CB PHE 334                                                                               36.053                                                                             35.994                                                                             57.257                                                                             1.00                                                                              16.25            1DLC2355                    ATOM  2232                                                                              CG PHE 334                                                                               36.519                                                                             35.602                                                                             55.891                                                                             1.00                                                                              15.09            1DLC2356                    ATOM  2233                                                                              CD1                                                                               PHE 334                                                                               37.286                                                                             34.455                                                                             55.702                                                                             1.00                                                                              13.90            1DLC2357                    ATOM  2234                                                                              CD2                                                                               PHE 334                                                                               36.141                                                                             36.350                                                                             54.779                                                                             1.00                                                                              13.34            1DLC2358                    ATOM  2235                                                                              CE1                                                                               PHE 334                                                                               37.663                                                                             34.056                                                                             54.422                                                                             1.00                                                                              11.52            1DLC2359                    ATOM  2236                                                                              CE2                                                                               PHE 334                                                                               36.516                                                                             35.958                                                                             53.496                                                                             1.00                                                                              14.32            1DLC2360                    ATOM  2237                                                                              CZ PHE 334                                                                               37.278                                                                             34.806                                                                             53.318                                                                             1.00                                                                              12.48            1DLC2361                    ATOM  2238                                                                              N  ASP 335                                                                               34.851                                                                             32.919                                                                             57.133                                                                             1.00                                                                              14.83            1DLC2362                    ATOM  2239                                                                              CA ASP 335                                                                               35.125                                                                             31.501                                                                             57.382                                                                             1.00                                                                              15.09            1DLC2363                    ATOM  2240                                                                              C  ASP 335                                                                               35.576                                                                             30.773                                                                             56.119                                                                             1.00                                                                              15.60            1DLC2364                    ATOM  2241                                                                              D  ASP 335                                                                               35.592                                                                             31.359                                                                             55.040                                                                             1.00                                                                              17.59            1DLC2365                    ATOM  2242                                                                              CB ASP 335                                                                               33.941                                                                             30.783                                                                             58.058                                                                             1.00                                                                              15.88            1DLC2366                    ATOM  2243                                                                              CG ASP 335                                                                               32.678                                                                             30.752                                                                             57.198                                                                             1.00                                                                              17.94            1DLC2367                    ATOM  2244                                                                              OD1                                                                               ASP 335                                                                               32.750                                                                             30.903                                                                             55.958                                                                             1.00                                                                              17.49            1DLC2368                    ATOM  2245                                                                              OD2                                                                               ASP 335                                                                               31.595                                                                             30.553                                                                             57.780                                                                             1.00                                                                              20.32            1DLC2369                    ATOM  2246                                                                              N  TYR 336                                                                               35.922                                                                             29.498                                                                             56.248                                                                             1.00                                                                              15.68            1DLC2370                    ATOM  2247                                                                              CA TYR 336                                                                               36.415                                                                             28.728                                                                             55.109                                                                             1.00                                                                              17.74            1DLC2371                    ATOM  2248                                                                              C  TYR 336                                                                               35.711                                                                             27.387                                                                             54.888                                                                             1.00                                                                              17.85            1DLC2372                    ATOM  2249                                                                              D  TYR 336                                                                               35.266                                                                             26.734                                                                             55.836                                                                             1.00                                                                              17.36            1DLC2373                    ATOM  2250                                                                              CB TYR 336                                                                               37.918                                                                             28.494                                                                             55.284                                                                             1.00                                                                              18.22            1DLC2374                    ATOM  2251                                                                              CG TYR 336                                                                               38.700                                                                             29.753                                                                             55.593                                                                             1.00                                                                              21.42            1DLC2375                    ATOM  2252                                                                              CD1                                                                               TYR 336                                                                               38.688                                                                             30.310                                                                             56.874                                                                             1.00                                                                              20.91            1DLC2376                    ATOM  2253                                                                              CD2                                                                               TYR 336                                                                               39.437                                                                             30.398                                                                             54.597                                                                             1.00                                                                              23.29            1DLC2377                    ATOM  2254                                                                              CE1                                                                               TYR 336                                                                               39.389                                                                             31.481                                                                             57.153                                                                             1.00                                                                              25.49            1DLC2378                    ATOM  2255                                                                              CE2                                                                               TYR 336                                                                               40.147                                                                             31.567                                                                             54.865                                                                             1.00                                                                              24.79            1DLC2379                    ATOM  2256                                                                              CZ TYR 336                                                                               40.119                                                                             32.105                                                                             56.142                                                                             1.00                                                                              25.10            1DLC2380                    ATOM  2257                                                                              OH TYR 336                                                                               40.820                                                                             33.262                                                                             56.402                                                                             1.00                                                                              25.35            1DLC2381                    ATOM  2258                                                                              N  LEU 337                                                                               35.634                                                                             26.968                                                                             53.631                                                                             1.00                                                                              17.01            1DLC2382                    ATOM  2259                                                                              CA LEU 337                                                                               34.999                                                                             25.701                                                                             53.284                                                                             1.00                                                                              22.05            1DLC2383                    ATOM  2260                                                                              C  LEU 337                                                                               35.753                                                                             24.564                                                                             53.983                                                                             1.00                                                                              25.09            1DLC2384                    ATOM  2261                                                                              O  LEU 337                                                                               36.971                                                                             24.429                                                                             53.851                                                                             1.00                                                                              27.06            1DLC2385                    ATOM  2262                                                                              CB LEU 337                                                                               35.041                                                                             25.493                                                                             51.765                                                                             1.00                                                                              19.73            1DLC2386                    ATOM  2263                                                                              CG LEU 337                                                                               34.001                                                                             24.618                                                                             51.045                                                                             1.00                                                                              20.25            1DLC2387                    ATOM  2264                                                                              CD1                                                                               LEU 337                                                                               34.715                                                                             23.668                                                                             50.117                                                                             1.00                                                                              16.93            1DLC2388                    ATOM  2265                                                                              CD2                                                                               LEU 337                                                                               33.109                                                                             23.867                                                                             52.007                                                                             1.00                                                                              15.63            1DLC2389                    ATOM  2266                                                                              N  HIS 338                                                                               35.038                                                                             23.753                                                                             54.746                                                                             1.00                                                                              27.56            1DLC2390                    ATOM  2267                                                                              CA HIS 338                                                                               35.686                                                                             22.654                                                                             55.447                                                                             1.00                                                                              32.45            1DLC2391                    ATOM  2268                                                                              C  HIS 338                                                                               35.223                                                                             21.263                                                                             55.002                                                                             1.00                                                                              35.81            1DLC2392                    ATOM  2269                                                                              O  HIS 338                                                                               36.040                                                                             20.350                                                                             54.825                                                                             1.00                                                                              37.52            1DLC2393                    ATOM  2270                                                                              CB HIS 338                                                                               35.485                                                                             22.810                                                                             56.952                                                                             1.00                                                                              31.95            1DLC2394                    ATOM  2271                                                                              CG HIS 338                                                                               36.423                                                                             21.983                                                                             57.771                                                                             1.00                                                                              35.39            1DLC2395                    ATOM  2272                                                                              ND1                                                                               HIS 338                                                                               36.028                                                                             20.835                                                                             58.424                                                                             1.00                                                                              39.61            1DLC2396                    ATOM  2273                                                                              CD2                                                                               HIS 338                                                                               37.740                                                                             22.140                                                                             58.047                                                                             1.00                                                                              35.97            1DLC2397                    ATOM  2274                                                                              CE1                                                                               HIS 338                                                                               37.060                                                                             20.320                                                                             59.070                                                                             1.00                                                                              39.82            1DLC2398                    ATOM  2275                                                                              NE2                                                                               HIS 338                                                                               38.110                                                                             21.093                                                                             58.856                                                                             1.00                                                                              39.08            1DLC2399                    ATOM  2276                                                                              N  ARG 339                                                                               33.918                                                                             21.111                                                                             54.801                                                                             1.00                                                                              36.63            1DLC2400                    ATOM  2277                                                                              CA ARG 339                                                                               33.361                                                                             19.824                                                                             54.417                                                                             1.00                                                                              37.71            1DLC2401                    ATOM  2278                                                                              C  ARG 339                                                                               32.016                                                                             19.948                                                                             53.704                                                                             1.00                                                                              35.21            1DLC2402                    ATOM  2279                                                                              O  ARG 339                                                                               31.294                                                                             20.928                                                                             53.889                                                                             1.00                                                                              34.83            1DLC2403                    ATOM  2280                                                                              CB ARG 339                                                                               33.231                                                                             18.972                                                                             55.684                                                                             1.00                                                                              43.00            1DLC2404                    ATOM  2281                                                                              CG ARG 339                                                                               32.608                                                                             17.602                                                                             55.526                                                                             1.00                                                                              48.56            1DLC2405                    ATOM  2282                                                                              CD ARG 339                                                                               33.140                                                                             16.657                                                                             56.611                                                                             1.00                                                                              57.10            1DLC2406                    ATOM  2283                                                                              NE ARG 339                                                                               33.391                                                                             17.338                                                                             57.888                                                                             1.00                                                                              62.49            1DLC2407                    ATOM  2284                                                                              CZ ARG 339                                                                               34.520                                                                             17.235                                                                             58.597                                                                             1.00                                                                              63.78            1DLC2408                    ATOM  2285                                                                              NH1                                                                               ARG 339                                                                               35.521                                                                             16.474                                                                             58.171                                                                             1.00                                                                              61.26            1DLC2409                    ATOM  2286                                                                              NH2                                                                               ARG 339                                                                               34.651                                                                             17.905                                                                             59.739                                                                             1.00                                                                              63.23            1DLC2410                    ATOM  2287                                                                              N  ILE 340                                                                               31.717                                                                             18.981                                                                             52.842                                                                             1.00                                                                              33.04            1DLC2411                    ATOM  2288                                                                              CA ILE 340                                                                               30.449                                                                             18.957                                                                             52.113                                                                             1.00                                                                              31.15            1DLC2412                    ATOM  2289                                                                              C  ILE 340                                                                               29.828                                                                             17.554                                                                             52.094                                                                             1.00                                                                              31.37            1DLC2413                    ATOM  2290                                                                              O  ILE 340                                                                               30.512                                                                             16.560                                                                             51.809                                                                             1.00                                                                              32.64            1DLC2414                    ATOM  2291                                                                              CB ILE 340                                                                               30.594                                                                             19.440                                                                             50.642                                                                             1.00                                                                              28.39            1DLC2415                    ATOM  2292                                                                              CG1                                                                               ILE 340                                                                               31.263                                                                             20.812                                                                             50.588                                                                             1.00                                                                              26.45            1DLC2416                    ATOM  2293                                                                              CG2                                                                               ILE 340                                                                               29.204                                                                             19.547                                                                             49.988                                                                             1.00                                                                              23.66            1DLC2417                    ATOM  2294                                                                              CD1                                                                               ILE 340                                                                               31.491                                                                             21.316                                                                             49.181                                                                             1.00                                                                              23.48            1DLC2418                    ATOM  2295                                                                              N  GLN 341                                                                               28.542                                                                             17.475                                                                             52.430                                                                             1.00                                                                              29.86            1DLC2419                    ATOM  2296                                                                              CA GLN 341                                                                               27.831                                                                             16.202                                                                             52.415                                                                             1.00                                                                              28.77            1DLC2420                    ATOM  2297                                                                              C  GLN 341                                                                               26.799                                                                             16.150                                                                             51.292                                                                             1.00                                                                              27.88            1DLC2421                    ATOM  2298                                                                              O  GLN 341                                                                               25.717                                                                             16.733                                                                             51.391                                                                             1.00                                                                              29.80            1DLC2422                    ATOM  2299                                                                              CB GLN 341                                                                               27.153                                                                             15.903                                                                             53.752                                                                             1.00                                                                              27.96            1DLC2423                    ATOM  2300                                                                              CG GLN 341                                                                               26.387                                                                             14.584                                                                             53.704                                                                             1.00                                                                              34.48            1DLC2424                    ATOM  2301                                                                              CD GLN 341                                                                               25.905                                                                             14.100                                                                             55.057                                                                             1.00                                                                              37.10            1DLC2425                    ATOM  2302                                                                              OE1                                                                               GLN 341                                                                               24.703                                                                             13.989                                                                             55.297                                                                             1.00                                                                              39.41            1DLC2426                    ATOM  2303                                                                              NE2                                                                               GLN 341                                                                               26.834                                                                             13.776                                                                             55.932                                                                             1.00                                                                              37.68            1DLC2427                    ATOM  2304                                                                              N  PHE 342                                                                               27.143                                                                             15.439                                                                             50.228                                                                             1.00                                                                              27.45            1DLC2428                    ATOM  2305                                                                              CA PHE 342                                                                               26.264                                                                             15.287                                                                             49.076                                                                             1.00                                                                              28.97            1DLC2429                    ATOM  2306                                                                              C  PHE 342                                                                               25.153                                                                             14.251                                                                             49.253                                                                             1.00                                                                              29.10            1DLC2430                    ATOM  2307                                                                              O  PHE 342                                                                               25.377                                                                             13.152                                                                             49.760                                                                             1.00                                                                              30.40            1DLC2431                    ATOM  2308                                                                              CB PHE 342                                                                               27.081                                                                             14.942                                                                             47.831                                                                             1.00                                                                              27.31            1DLC2432                    ATOM  2309                                                                              CG PHE 342                                                                               27.994                                                                             16.038                                                                             47.389                                                                             1.00                                                                              26.99            1DLC2433                    ATOM  2310                                                                              CD1                                                                               PHE 342                                                                               29.200                                                                             16.257                                                                             48.036                                                                             1.00                                                                              28.62            1DLC2434                    ATOM  2311                                                                              CD2                                                                               PHE 342                                                                               27.646                                                                             16.860                                                                             46.327                                                                             1.00                                                                              27.99            1DLC2435                    ATOM  2312                                                                              CE1                                                                               PHE 342                                                                               30.045                                                                             17.281                                                                             47.631                                                                             1.00                                                                              29.72            1DLC2436                    ATOM  2313                                                                              CE2                                                                               PHE 342                                                                               28.484                                                                             17.886                                                                             45.915                                                                             1.00                                                                              28.28            1DLC2437                    ATOM  2314                                                                              CZ PHE 342                                                                               29.684                                                                             18.096                                                                             46.568                                                                             1.00                                                                              29.89            1DLC2438                    ATOM  2315                                                                              N  HIS 343                                                                               23.936                                                                             14.647                                                                             48.898                                                                             1.00                                                                              31.24            1DLC2439                    ATOM  2316                                                                              CA HIS 343                                                                               22.780                                                                             13.760                                                                             48.966                                                                             1.00                                                                              30.73            1DLC2440                    ATOM  2317                                                                              C  HIS 343                                                                               22.330                                                                             13.517                                                                             47.544                                                                             1.00                                                                              30.25            1DLC2441                    ATOM  2318                                                                              O  HIS 343                                                                               22.214                                                                             14.456                                                                             46.760                                                                             1.00                                                                              30.83            1DLC2442                    ATOM  2319                                                                              CB HIS 343                                                                               21.644                                                                             14.367                                                                             49.786                                                                             1.00                                                                              27.80            1DLC2443                    ATOM  2320                                                                              CG HIS 343                                                                               21.840                                                                             14.231                                                                             51.263                                                                             1.00                                                                              28.77            1DLC2444                    ATOM  2321                                                                              ND1                                                                               HIS 343                                                                               22.925                                                                             14.766                                                                             51.922                                                                             1.00                                                                              32.44            1DLC2445                    ATOM  2322                                                                              CD2                                                                               HIS 343                                                                               21.101                                                                             13.601                                                                             52.207                                                                             1.00                                                                              27.79            1DLC2446                    ATOM  2323                                                                              CE1                                                                               HIS 343                                                                               22.849                                                                             14.472                                                                             53.205                                                                             1.00                                                                              30.66            1DLC2447                    ATOM  2324                                                                              NE2                                                                               HIS 343                                                                               21.751                                                                             13.766                                                                             53.404                                                                             1.00                                                                              30.61            1DLC2448                    ATOM  2325                                                                              N  THR 344                                                                               22.118                                                                             12.248                                                                             47.214                                                                             1.00                                                                              30.51            1DLC2449                    ATOM  2326                                                                              CA THR 344                                                                               21.707                                                                             11.853                                                                             45.873                                                                             1.00                                                                              30.88            1DLC2450                    ATOM  2327                                                                              C  THR 344                                                                               20.344                                                                             11.154                                                                             45.812                                                                             1.00                                                                              33.44            1DLC2451                    ATOM  2328                                                                              O  THR 344                                                                               19.928                                                                             10.442                                                                             46.744                                                                             1.00                                                                              32.56            1DLC2452                    ATOM  2329                                                                              CB THR 344                                                                               22.775                                                                             10.938                                                                             45.225                                                                             1.00                                                                              26.81            1DLC2453                    ATOM  2330                                                                              OG1                                                                               THR 344                                                                               24.046                                                                             11.597                                                                             45.262                                                                             1.00                                                                              29.11            1DLC2454                    ATOM  2331                                                                              CG2                                                                               THR 344                                                                               22.430                                                                             10.614                                                                             43.785                                                                             1.00                                                                              24.42            1DLC2455                    ATOM  2332                                                                              N  ARG 345                                                                               19.655                                                                             11.385                                                                             44.698                                                                             1.00                                                                              32.36            1DLC2456                    ATOM  2333                                                                              CA ARG 345                                                                               18.352                                                                             10.796                                                                             44.433                                                                             1.00                                                                              29.58            1DLC2457                    ATOM  2334                                                                              C  ARG 345                                                                               18.289                                                                             10.272                                                                             43.010                                                                             1.00                                                                              29.62            1DLC2458                    ATOM  2335                                                                              O  ARG 345                                                                               19.079                                                                             10.681                                                                             42.145                                                                             1.00                                                                              27.21            1DLC2459                    ATOM  2336                                                                              CB ARG 345                                                                               17.233                                                                             11.812                                                                             44.659                                                                             1.00                                                                              26.82            1DLC2460                    ATOM  2337                                                                              CG ARG 345                                                                               16.905                                                                             12.019                                                                             46.118                                                                             1.00                                                                              25.81            1DLC2461                    ATOM  2338                                                                              CD ARG 345                                                                               15.509                                                                             12.552                                                                             46.288                                                                             1.00                                                                              25.24            1DLC2462                    ATOM  2339                                                                              NE ARG 345                                                                               15.127                                                                             12.531                                                                             47.692                                                                             1.00                                                                              30.00            1DLC2463                    ATOM  2340                                                                              CZ ARG 345                                                                               13.978                                                                             12.998                                                                             48.167                                                                             1.00                                                                              32.09            1DLC2464                    ATOM  2341                                                                              NH1                                                                               ARG 345                                                                               13.076                                                                             13.525                                                                             47.348                                                                             1.00                                                                              32.16            1DLC2465                    ATOM  2342                                                                              NH2                                                                               ARG 345                                                                               13.749                                                                             12.978                                                                             49.473                                                                             1.00                                                                              33.30            1DLC2466                    ATOM  2343                                                                              N  PHE 346                                                                               17.391                                                                             9.316                                                                              42.796                                                                             1.00                                                                              27.16            1DLC2467                    ATOM  2344                                                                              CA PHE 346                                                                               17.193                                                                             8.715                                                                              41.487                                                                             1.00                                                                              26.42            1DLC2468                    ATOM  2345                                                                              C  PHE 346                                                                               16.082                                                                             9.404                                                                              40.701                                                                             1.00                                                                              26.65            1DLC2469                    ATOM  2346                                                                              O  PHE 346                                                                               15.003                                                                             9.651                                                                              41.224                                                                             1.00                                                                              27.28            1DLC2470                    ATOM  2347                                                                              CB PHE 346                                                                               16.875                                                                             7.222                                                                              41.633                                                                             1.00                                                                              25.70            1DLC2471                    ATOM  2348                                                                              CG PHE 346                                                                               16.431                                                                             6.565                                                                              40.349                                                                             1.00                                                                              24.42            1DLC2472                    ATOM  2349                                                                              CD1                                                                               PHE 346                                                                               17.296                                                                             6.461                                                                              39.267                                                                             1.00                                                                              25.47            1DLC2473                    ATOM  2350                                                                              CD2                                                                               PHE 346                                                                               15.145                                                                             6.057                                                                              40.222                                                                             1.00                                                                              24.17            1DLC2474                    ATOM  2351                                                                              CE1                                                                               PHE 346                                                                               16.884                                                                             5.863                                                                              38.079                                                                             1.00                                                                              26.24            1DLC2475                    ATOM  2352                                                                              CE2                                                                               PHE 346                                                                               14.726                                                                             5.457                                                                              39.037                                                                             1.00                                                                              22.53            1DLC2476                    ATOM  2353                                                                              CZ PHE 346                                                                               15.594                                                                             5.359                                                                              37.966                                                                             1.00                                                                              22.75            1DLC2477                    ATOM  2354                                                                              N  GLN 347                                                                               16.365                                                                             9.747                                                                              39.452                                                                             1.00                                                                              26.19            1DLC2478                    ATOM  2355                                                                              CA GLN 347                                                                               15.361                                                                             10.368                                                                             38.602                                                                             1.00                                                                              28.50            1DLC2479                    ATOM  2356                                                                              C  GLN 347                                                                               15.031                                                                             9.390                                                                              37.497                                                                             1.00                                                                              29.83            1DLC2480                    ATOM  2357                                                                              O  GLN 347                                                                               15.876                                                                             9.075                                                                              36.649                                                                             1.00                                                                              29.71            1DLC2481                    ATOM  2358                                                                              CB GLN 347                                                                               15.840                                                                             11.692                                                                             38.001                                                                             1.00                                                                              30.26            1DLC2482                    ATOM  2359                                                                              CG GLN 347                                                                               14.880                                                                             12.280                                                                             36.951                                                                             1.00                                                                              29.03            1DLC2483                    ATOM  2360                                                                              CD GLN 347                                                                               13.454                                                                             12.473                                                                             37.471                                                                             1.00                                                                              31.21            1DLC2484                    ATOM  2361                                                                              OE1                                                                               GLN 347                                                                               13.234                                                                             13.083                                                                             38.515                                                                             1.00                                                                              31.71            1DLC2485                    ATOM  2362                                                                              NE2                                                                               GLN 347                                                                               12.482                                                                             11.949                                                                             36.739                                                                             1.00                                                                              34.89            1DLC2486                    ATOM  2363                                                                              N  PRO 348                                                                               13.816                                                                             8.831                                                                              37.537                                                                             1.00                                                                              29.99            1DLC2487                    ATOM  2364                                                                              CA PRO 348                                                                               13.392                                                                             7.873                                                                              36.521                                                                             1.00                                                                              30.56            1DLC2488                    ATOM  2365                                                                              C  PRO 348                                                                               13.079                                                                             8.512                                                                              35.180                                                                             1.00                                                                              31.08            1DLC2489                    ATOM  2366                                                                              O  PRO 348                                                                               12.571                                                                             9.630                                                                              35.109                                                                             1.00                                                                              29.47            1DLC2490                    ATOM  2367                                                                              CB PRO 348                                                                               12.148                                                                             7.249                                                                              37.146                                                                             1.00                                                                              30.82            1DLC2491                    ATOM  2368                                                                              CG PRO 348                                                                               11.586                                                                             8.367                                                                              37.960                                                                             1.00                                                                              28.95            1DLC2492                    ATOM  2369                                                                              CD PRO 348                                                                               12.814                                                                             8.934                                                                              38.613                                                                             1.00                                                                              28.01            1DLC2493                    ATOM  2370                                                                              N  GLY 349                                                                               13.494                                                                             7.835                                                                              34.122                                                                             1.00                                                                              32.08            1DLC2494                    ATOM  2371                                                                              CA GLY 349                                                                               13.203                                                                             8.310                                                                              32.788                                                                             1.00                                                                              36.84            1DLC2495                    ATOM  2372                                                                              C  GLY 349                                                                               11.906                                                                             7.627                                                                              32.382                                                                             1.00                                                                              40.08            1DLC2496                    ATOM  2373                                                                              O  GLY 349                                                                               11.629                                                                             6.511                                                                              32.825                                                                             1.00                                                                              39.90            1DLC2497                    ATOM  2374                                                                              N  TYR 350                                                                               11.103                                                                             8.277                                                                              31.550                                                                             1.00                                                                              42.86            1DLC2498                    ATOM  2375                                                                              CA TYR 350                                                                               9.836                                                                              7.697                                                                              31.119                                                                             1.00                                                                              42.49            1DLC2499                    ATOM  2376                                                                              C  TYR 350                                                                               9.976                                                                              6.282                                                                              30.548                                                                             1.00                                                                              42.42            1DLC2500                    ATOM  2377                                                                              O  TYR 350                                                                               9.096                                                                              5.447                                                                              30.742                                                                             1.00                                                                              38.59            1DLC2501                    ATOM  2378                                                                              CB TYR 350                                                                               9.157                                                                              8.611                                                                              30.107                                                                             1.00                                                                              41.54            1DLC2502                    ATOM  2379                                                                              CG TYR 350                                                                               7.723                                                                              8.243                                                                              29.846                                                                             1.00                                                                              42.11            1DLC2503                    ATOM  2380                                                                              CD1                                                                               TYR 350                                                                               6.758                                                                              8.372                                                                              30.846                                                                             1.00                                                                              42.70            1DLC2504                    ATOM  2381                                                                              CD2                                                                               TYR 350                                                                               7.323                                                                              7.778                                                                              28.597                                                                             1.00                                                                              41.41            1DLC2505                    ATOM  2382                                                                              CE1                                                                               TYR 350                                                                               5.428                                                                              8.051                                                                              30.604                                                                             1.00                                                                              43.17            1DLC2506                    ATOM  2383                                                                              CE2                                                                               TYR 350                                                                               6.002                                                                              7.453                                                                              28.345                                                                             1.00                                                                              44.30            1DLC2507                    ATOM  2384                                                                              CZ TYR 350                                                                               5.060                                                                              7.594                                                                              29.350                                                                             1.00                                                                              44.01            1DLC2508                    ATOM  2385                                                                              OH TYR 350                                                                               3.751                                                                              7.285                                                                              29.084                                                                             1.00                                                                              51.17            1DLC2509                    ATOM  2386                                                                              N  TYR 351                                                                               11.091                                                                             6.013                                                                              29.870                                                                             1.00                                                                              46.30            1DLC2510                    ATOM  2387                                                                              CA TYR 351                                                                               11.342                                                                             4.689                                                                              29.293                                                                             1.00                                                                              49.39            1DLC2511                    ATOM  2388                                                                              C  TYR 351                                                                               12.413                                                                             3.853                                                                              30.005                                                                             1.00                                                                              50.19            1DLC2512                    ATOM  2389                                                                              O  TYR 351                                                                               12.900                                                                             2.862                                                                              29.459                                                                             1.00                                                                              49.12            1DLC2513                    ATOM  2390                                                                              CB TYR 351                                                                               11.660                                                                             4.807                                                                              27.805                                                                             1.00                                                                              52.75            1DLC2514                    ATOM  2391                                                                              CG TYR 351                                                                               10.484                                                                             5.296                                                                              27.001                                                                             1.00                                                                              59.62            1DLC2515                    ATOM  2392                                                                              CD1                                                                               TYR 351                                                                               9.431                                                                              4.437                                                                              26.674                                                                             1.00                                                                              60.34            1DLC2516                    ATOM  2393                                                                              CD2                                                                               TYR 351                                                                               10.401                                                                             6.629                                                                              26.596                                                                             1.00                                                                              62.29            1DLC2517                    ATOM  2394                                                                              CE1                                                                               TYR 351                                                                               8.324                                                                              4.896                                                                              25.964                                                                             1.00                                                                              62.98            1DLC2518                    ATOM  2395                                                                              CE2                                                                               TYR 351                                                                               9.299                                                                              7.101                                                                              25.888                                                                             1.00                                                                              64.82            1DLC2519                    ATOM  2396                                                                              CZ TYR 351                                                                               8.263                                                                              6.231                                                                              25.577                                                                             1.00                                                                              66.21            1DLC2520                    ATOM  2397                                                                              OH TYR 351                                                                               7.167                                                                              6.710                                                                              24.891                                                                             1.00                                                                              71.16            1DLC2521                    ATOM  2398                                                                              N  GLY 352                                                                               12.764                                                                             4.247                                                                              31.229                                                                             1.00                                                                              51.80            1DLC2522                    ATOM  2399                                                                              CA GLY 352                                                                               13.756                                                                             3.519                                                                              32.013                                                                             1.00                                                                              54.02            1DLC2523                    ATOM  2400                                                                              C  GLY 352                                                                               15.203                                                                             3.694                                                                              31.585                                                                             1.00                                                                              54.76            1DLC2524                    ATOM  2401                                                                              O  GLY 352                                                                               16.086                                                                             3.933                                                                              32.407                                                                             1.00                                                                              56.76            1DLC2525                    ATOM  2402                                                                              N  ASN 353                                                                               15.439                                                                             3.562                                                                              30.289                                                                             1.00                                                                              54.09            1DLC2526                    ATOM  2403                                                                              CA ASN 353                                                                               16.768                                                                             3.700                                                                              29.702                                                                             1.00                                                                              54.37            1DLC2527                    ATOM  2404                                                                              C  ASN 353                                                                               17.383                                                                             5.096                                                                              29.857                                                                             1.00                                                                              52.91            1DLC2528                    ATOM  2405                                                                              O  ASN 353                                                                               18.599                                                                             5.253                                                                              29.836                                                                             1.00                                                                              53.09            1DLC2529                    ATOM  2406                                                                              CB ASN 353                                                                               16.685                                                                             3.347                                                                              28.216                                                                             1.00                                                                              58.15            1DLC2530                    ATOM  2407                                                                              CG ASN 353                                                                               15.459                                                                             3.949                                                                              27.538                                                                             1.00                                                                              61.25            1DLC2531                    ATOM  2408                                                                              OD1                                                                               ASN 353                                                                               15.047                                                                             5.069                                                                              27.845                                                                             1.00                                                                              63.28            1DLC2532                    ATOM  2409                                                                              ND2                                                                               ASN 353                                                                               14.855                                                                             3.194                                                                              26.635                                                                             1.00                                                                              64.45            1DLC2533                    ATOM  2410                                                                              N  ASP 354                                                                               16.528                                                                             6.097                                                                              30.021                                                                             1.00                                                                              50.29            1DLC2534                    ATOM  2411                                                                              CA ASP 354                                                                               16.961                                                                             7.488                                                                              30.140                                                                             1.00                                                                              46.56            1DLC2535                    ATOM  2412                                                                              C  ASP 354                                                                               17.013                                                                             8.056                                                                              31.560                                                                             1.00                                                                              45.20            1DLC2536                    ATOM  2413                                                                              D  ASP 354                                                                               16.987                                                                             9.277                                                                              31.759                                                                             1.00                                                                              41.77            1DLC2537                    ATOM  2414                                                                              CB ASP 354                                                                               16.062                                                                             8.362                                                                              29.269                                                                             1.00                                                                              47.89            1DLC2538                    ATOM  2415                                                                              CG ASP 354                                                                               14.594                                                                             8.263                                                                              29.652                                                                             1.00                                                                              49.69            1DLC2539                    ATOM  2416                                                                              OD1                                                                               ASP 354                                                                               14.110                                                                             7.156                                                                              29.988                                                                             1.00                                                                              49.83            1DLC2540                    ATOM  2417                                                                              OD2                                                                               ASP 354                                                                               13.921                                                                             9.309                                                                              29.616                                                                             1.00                                                                              53.54            1DLC2541                    ATOM  2418                                                                              N  SER 355                                                                               17.088                                                                             7.170                                                                              32.545                                                                             1.00                                                                              42.98            1DLC2542                    ATOM  2419                                                                              CA SER 355                                                                               17.141                                                                             7.582                                                                              33.946                                                                             1.00                                                                              42.29            1DLC2543                    ATOM  2420                                                                              C  SER 355                                                                               18.522                                                                             8.087                                                                              34.354                                                                             1.00                                                                              39.61            1DLC2544                    ATOM  2421                                                                              O  SER 355                                                                               19.501                                                                             7.891                                                                              33.636                                                                             1.00                                                                              40.89            1DLC2545                    ATOM  2422                                                                              CB SER 355                                                                               16.752                                                                             6.407                                                                              34.837                                                                             1.00                                                                              45.53            1DLC2546                    ATOM  2423                                                                              OG SER 355                                                                               15.491                                                                             5.879                                                                              34.453                                                                             1.00                                                                              49.12            1DLC2547                    ATOM  2424                                                                              N  PHE 356                                                                               18.595                                                                             8.753                                                                              35.500                                                                             1.00                                                                              35.84            1DLC2548                    ATOM  2425                                                                              CA PHE 356                                                                               19.863                                                                             9.268                                                                              36.013                                                                             1.00                                                                              33.36            1DLC2549                    ATOM  2426                                                                              C  PHE 356                                                                               19.735                                                                             9.633                                                                              37.486                                                                             1.00                                                                              33.41            1DLC2550                    ATOM  2427                                                                              O  PHE 356                                                                               18.626                                                                             9.773                                                                              38.006                                                                             1.00                                                                              33.51            1DLC2551                    ATOM  2428                                                                              CB PHE 356                                                                               20.358                                                                             10.484                                                                             35.200                                                                             1.00                                                                              30.78            1DLC2552                    ATOM  2429                                                                              CG PHE 356                                                                               19.510                                                                             11.727                                                                             35.353                                                                             1.00                                                                              30.29            1DLC2553                    ATOM  2430                                                                              CD1                                                                               PHE 356                                                                               18.374                                                                             11.921                                                                             34.568                                                                             1.00                                                                              30.93            1DLC2554                    ATOM  2431                                                                              CD2                                                                               PHE 356                                                                               19.849                                                                             12.709                                                                             36.278                                                                             1.00                                                                              29.49            1DLC2555                    ATOM  2432                                                                              CE1                                                                               PHE 356                                                                               17.592                                                                             13.073                                                                             34.708                                                                             1.00                                                                              27.44            1DLC2556                    ATOM  2433                                                                              CE2                                                                               PHE 356                                                                               19.071                                                                             13.864                                                                             36.424                                                                             1.00                                                                              26.60            1DLC2557                    ATOM  2434                                                                              CZ PHE 356                                                                               17.946                                                                             14.044                                                                             35.640                                                                             1.00                                                                              27.20            1DLC2558                    ATOM  2435                                                                              N  ASN 357                                                                               20.864                                                                             9.665                                                                              38.183                                                                             1.00                                                                              34.56            1DLC2559                    ATOM  2436                                                                              CA ASN 357                                                                               20.883                                                                             10.051                                                                             39.594                                                                             1.00                                                                              34.66            1DLC2560                    ATOM  2437                                                                              C  ASN 357                                                                               21.299                                                                             11.510                                                                             39.637                                                                             1.00                                                                              31.40            1DLC2561                    ATOM  2438                                                                              O  ASN 357                                                                               21.977                                                                             11.990                                                                             38.726                                                                             1.00                                                                              30.66            1DLC2562                    ATOM  2439                                                                              CB ASN 357                                                                               21.892                                                                             9.221                                                                              40.385                                                                             1.00                                                                              38.51            1DLC2563                    ATOM  2440                                                                              CG ASN 357                                                                               21.411                                                                             7.816                                                                              40.658                                                                             1.00                                                                              40.71            1DLC2564                    ATOM  2441                                                                              OD1                                                                               ASN 357                                                                               22.211                                                                             6.921                                                                              40.897                                                                             1.00                                                                              45.00            1DLC2565                    ATOM  2442                                                                              ND2                                                                               ASN 357                                                                               20.103                                                                             7.611                                                                              40.629                                                                             1.00                                                                              42.48            1DLC2566                    ATOM  2443                                                                              N  TYR 358                                                                               20.923                                                                             12.219                                                                             40.688                                                                             1.00                                                                              27.67            1DLC2567                    ATOM  2444                                                                              CA TYR 358                                                                               21.294                                                                             13.620                                                                             40.758                                                                             1.00                                                                              26.55            1DLC2568                    ATOM  2445                                                                              C  TYR 358                                                                               21.457                                                                             14.115                                                                             42.186                                                                             1.00                                                                              26.59            1DLC2569                    ATOM  2446                                                                              O  TYR 358                                                                               20.937                                                                             13.521                                                                             43.132                                                                             1.00                                                                              24.94            1DLC2570                    ATOM  2447                                                                              CB TYR 358                                                                               20.272                                                                             14.483                                                                             39.999                                                                             1.00                                                                              25.94            1DLC2571                    ATOM  2448                                                                              CG TYR 358                                                                               18.936                                                                             14.556                                                                             40.683                                                                             1.00                                                                              27.85            1DLC2572                    ATOM  2449                                                                              CD1                                                                               TYR 358                                                                               17.962                                                                             13.584                                                                             40.461                                                                             1.00                                                                              31.47            1DLC2573                    ATOM  2450                                                                              CD2                                                                               TYR 358                                                                               18.679                                                                             15.546                                                                             41.630                                                                             1.00                                                                              32.37            1DLC2574                    ATOM  2451                                                                              CE1                                                                               TYR 358                                                                               16.765                                                                             13.587                                                                             41.180                                                                             1.00                                                                              34.73            1DLC2575                    ATOM  2452                                                                              CE2                                                                               TYR 358                                                                               17.494                                                                             15.562                                                                             42.354                                                                             1.00                                                                              36.61            1DLC2576                    ATOM  2453                                                                              CZ TYR 358                                                                               16.541                                                                             14.581                                                                             42.131                                                                             1.00                                                                              38.10            1DLC2577                    ATOM  2454                                                                              OH TYR 358                                                                               15.384                                                                             14.586                                                                             42.886                                                                             1.00                                                                              45.04            1DLC2578                    ATOM  2455                                                                              N  TRP 359                                                                               22.212                                                                             15.200                                                                             42.318                                                                             1.00                                                                              27.94            1DLC2579                    ATOM  2456                                                                              CA TRP 359                                                                               22.487                                                                             15.852                                                                             43.596                                                                             1.00                                                                              26.27            1DLC2580                    ATOM  2457                                                                              C  TRP 359                                                                               21.183                                                                             16.510                                                                             44.063                                                                             1.00                                                                              24.40            1DLC2581                    ATOM  2458                                                                              O  TRP 359                                                                               20.694                                                                             17.462                                                                             43.449                                                                             1.00                                                                              25.89            1DLC2582                    ATOM  2459                                                                              CB TRP 359                                                                               23.596                                                                             16.890                                                                             43.382                                                                             1.00                                                                              23.83            1DLC2583                    ATOM  2460                                                                              CG TRP 359                                                                               24.070                                                                             17.584                                                                             44.604                                                                             1.00                                                                              24.65            1DLC2584                    ATOM  2461                                                                              CD1                                                                               TRP 359                                                                               23.782                                                                             17.267                                                                             45.901                                                                             1.00                                                                              25.90            1DLC2585                    ATOM  2462                                                                              CD2                                                                               TRP 359                                                                               24.919                                                                             18.733                                                                             44.649                                                                             1.00                                                                              25.70            1DLC2586                    ATOM  2463                                                                              NE1                                                                               TRP 359                                                                               24.396                                                                             18.152                                                                             46.752                                                                             1.00                                                                              25.43            1DLC2587                    ATOM  2464                                                                              CE2                                                                               TRP 359                                                                               25.103                                                                             19.062                                                                             46.011                                                                             1.00                                                                              27.53            1DLC2588                    ATOM  2465                                                                              CE3                                                                               TRP 359                                                                               25.547                                                                             19.518                                                                             43.669                                                                             1.00                                                                              26.62            1DLC2589                    ATOM  2466                                                                              CZ2                                                                               TRP 359                                                                               25.894                                                                             20.147                                                                             46.419                                                                             1.00                                                                              27.25            1DLC2590                    ATOM  2467                                                                              CZ3                                                                               TRP 359                                                                               26.333                                                                             20.596                                                                             44.075                                                                             1.00                                                                              25.15            1DLC2591                    ATOM  2468                                                                              CH2                                                                               TRP 359                                                                               26.498                                                                             20.897                                                                             45.437                                                                             1.00                                                                              26.00            1DLC2592                    ATOM  2469                                                                              N  SER 360                                                                               20.610                                                                             15.977                                                                             45.132                                                                             1.00                                                                              22.69            1DLC2593                    ATOM  2470                                                                              CA SER 360                                                                               19.339                                                                             16.473                                                                             45.654                                                                             1.00                                                                              23.95            1DLC2594                    ATOM  2471                                                                              C  SER 360                                                                               19.405                                                                             17.470                                                                             46.812                                                                             1.00                                                                              25.02            1DLC2595                    ATOM  2472                                                                              O  SER 360                                                                               18.520                                                                             18.317                                                                             46.966                                                                             1.00                                                                              26.55            1DLC2596                    ATOM  2473                                                                              CB SER 360                                                                               18.460                                                                             15.289                                                                             46.060                                                                             1.00                                                                              22.05            1DLC2597                    ATOM  2474                                                                              OG SER 360                                                                               19.050                                                                             14.555                                                                             47.123                                                                             1.00                                                                              20.36            1DLC2598                    ATOM  2475                                                                              N  GLY 361                                                                               20.422                                                                             17.345                                                                             47.653                                                                             1.00                                                                              23.75            1DLC2599                    ATOM  2476                                                                              CA GLY 361                                                                               20.542                                                                             18.246                                                                             48.782                                                                             1.00                                                                              21.17            1DLC2600                    ATOM  2477                                                                              C  GLY 361                                                                               21.935                                                                             18.193                                                                             49.361                                                                             1.00                                                                              24.69            1DLC2601                    ATOM  2478                                                                              O  GLY 361                                                                               22.789                                                                             17.443                                                                             48.871                                                                             1.00                                                                              26.41            1DLC2602                    ATOM  2479                                                                              N  ASN 362                                                                               22.181                                                                             18.955                                                                             50.419                                                                             1.00                                                                              22.30            1DLC2603                    ATOM  2480                                                                              CA ASN 362                                                                               23.510                                                                             18.954                                                                             51.003                                                                             1.00                                                                              22.20            1DLC2604                    ATOM  2481                                                                              C  ASN 362                                                                               23.590                                                                             19.569                                                                             52.381                                                                             1.00                                                                              21.51            1DLC2605                    ATOM  2482                                                                              O  ASN 362                                                                               22.643                                                                             20.179                                                                             52.871                                                                             1.00                                                                              20.57            1DLC2606                    ATOM  2483                                                                              CB ASN 362                                                                               24.485                                                                             19.713                                                                             50.089                                                                             1.00                                                                              24.04            1DLC2607                    ATOM  2484                                                                              CG ASN 362                                                                               24.420                                                                             21.228                                                                             50.291                                                                             1.00                                                                              28.34            1DLC2608                    ATOM  2485                                                                              OD1                                                                               ASN 362                                                                               25.165                                                                             21.789                                                                             51.088                                                                             1.00                                                                              28.65            1DLC2609                    ATOM  2486                                                                              ND2                                                                               ASN 362                                                                               23.516                                                                             21.885                                                                             49.593                                                                             1.00                                                                              26.03            1DLC2610                    ATOM  2487                                                                              N  TYR 363                                                                               24.743                                                                             19.346                                                                             52.993                                                                             1.00                                                                              24.00            1DLC2611                    ATOM  2488                                                                              CA TYR 363                                                                               25.118                                                                             19.902                                                                             54.286                                                                             1.00                                                                              26.62            1DLC2612                    ATOM  2489                                                                              C  TYR 363                                                                               26.466                                                                             20.551                                                                             53.960                                                                             1.00                                                                              28.28            1DLC2613                    ATOM  2490                                                                              O  TYR 363                                                                               27.191                                                                             20.085                                                                             53.067                                                                             1.00                                                                              27.60            1DLC2614                    ATOM  2491                                                                              CB TYR 363                                                                               25.381                                                                             18.810                                                                             55.329                                                                             1.00                                                                              27.58            1DLC2615                    ATOM  2492                                                                              CG TYR 363                                                                               24.178                                                                             18.317                                                                             56.087                                                                             1.00                                                                              28.34            1DLC2616                    ATOM  2493                                                                              CD1                                                                               TYR 363                                                                               23.515                                                                             19.138                                                                             56.997                                                                             1.00                                                                              29.04            1DLC2617                    ATOM  2494                                                                              CD2                                                                               TYR 363                                                                               23.719                                                                             17.016                                                                             55.915                                                                             1.00                                                                              30.38            1DLC2618                    ATOM  2495                                                                              CE1                                                                               TYR 363                                                                               22.425                                                                             18.672                                                                             57.718                                                                             1.00                                                                              32.23            1DLC2619                    ATOM  2496                                                                              CE2                                                                               TYR 363                                                                               22.630                                                                             16.537                                                                             56.628                                                                             1.00                                                                              33.13            1DLC2620                    ATOM  2497                                                                              CZ TYR 363                                                                               21.985                                                                             17.366                                                                             57.529                                                                             1.00                                                                              34.94            1DLC2621                    ATOM  2498                                                                              OH TYR 363                                                                               20.902                                                                             16.876                                                                             58.232                                                                             1.00                                                                              36.70            1DLC2622                    ATOM  2499                                                                              N  VAL 364                                                                               26.791                                                                             21.640                                                                             54.641                                                                             1.00                                                                              28.34            1DLC2623                    ATOM  2500                                                                              CA VAL 364                                                                               28.075                                                                             22.294                                                                             54.431                                                                             1.00                                                                              26.27            1DLC2624                    ATOM  2501                                                                              C  VAL 364                                                                               28.651                                                                             22.630                                                                             55.790                                                                             1.00                                                                              24.54            1DLC2625                    ATOM  2502                                                                              O  VAL 364                                                                               27.923                                                                             22.972                                                                             56.722                                                                             1.00                                                                              27.34            1DLC2626                    ATOM  2503                                                                              CB VAL 364                                                                               27.957                                                                             23.592                                                                             53.612                                                                             1.00                                                                              28.72            1DLC2627                    ATOM  2504                                                                              CG1                                                                               VAL 364                                                                               29.333                                                                             24.079                                                                             53.197                                                                             1.00                                                                              30.77            1DLC2628                    ATOM  2505                                                                              CG2                                                                               VAL 364                                                                               27.135                                                                             23.356                                                                             52.393                                                                             1.00                                                                              36.32            1DLC2629                    ATOM  2506                                                                              N  SER 365                                                                               29.953                                                                             22.456                                                                             55.920                                                                             1.00                                                                              24.40            1DLC2630                    ATOM  2507                                                                              CA SER 365                                                                               30.639                                                                             22.766                                                                             57.166                                                                             1.00                                                                              24.54            1DLC2631                    ATOM  2508                                                                              C  SER 365                                                                               31.804                                                                             23.688                                                                             56.850                                                                             1.00                                                                              23.42            1DLC2632                    ATOM  2509                                                                              O  SER 365                                                                               32.538                                                                             23.477                                                                             55.883                                                                             1.00                                                                              21.82            1DLC2633                    ATOM  2510                                                                              CB SER 365                                                                               31.166                                                                             21.496                                                                             57.845                                                                             1.00                                                                              27.44            1DLC2634                    ATOM  2511                                                                              OG SER 365                                                                               30.117                                                                             20.716                                                                             58.400                                                                             1.00                                                                              34.19            1DLC2635                    ATOM  2512                                                                              N  THR 366                                                                               31.938                                                                             24.737                                                                             57.645                                                                             1.00                                                                              21.84            1DLC2636                    ATOM  2513                                                                              CA THR 366                                                                               33.018                                                                             25.690                                                                             57.469                                                                             1.00                                                                              23.59            1DLC2637                    ATOM  2514                                                                              C  THR 366                                                                               33.789                                                                             25.846                                                                             58.767                                                                             1.00                                                                              24.57            1DLC2638                    ATOM  2515                                                                              O  THR 366                                                                               33.265                                                                             25.580                                                                             59.851                                                                             1.00                                                                              21.97            1DLC2639                    ATOM  2516                                                                              CB THR 366                                                                               32.502                                                                             27.105                                                                             57.062                                                                             1.00                                                                              22.30            1DLC2640                    ATOM  2517                                                                              OG1                                                                               THR 366                                                                               31.532                                                                             27.558                                                                             58.015                                                                             1.00                                                                              21.18            1DLC2641                    ATOM  2518                                                                              CG2                                                                               THR 366                                                                               31.913                                                                             27.107                                                                             55.641                                                                             1.00                                                                              16.40            1DLC2642                    ATOM  2519                                                                              N  ARG 367                                                                               35.060                                                                             26.198                                                                             58.654                                                                             1.00                                                                              23.86            1DLC2643                    ATOM  2520                                                                              CA ARG 367                                                                               35.843                                                                             26.439                                                                             59.849                                                                             1.00                                                                              26.59            1DLC2644                    ATOM  2521                                                                              C  ARG 367                                                                               35.989                                                                             27.960                                                                             59.945                                                                             1.00                                                                              25.50            1DLC2645                    ATOM  2522                                                                              O  ARG 367                                                                               36.029                                                                             28.663                                                                             58.923                                                                             1.00                                                                              23.82            1DLC2646                    ATOM  2523                                                                              CB ARG 367                                                                               37.201                                                                             25.721                                                                             59.819                                                                             1.00                                                                              28.50            1DLC2647                    ATOM  2524                                                                              CG ARG 367                                                                               38.231                                                                             26.244                                                                             58.838                                                                             1.00                                                                              33.38            1DLC2648                    ATOM  2525                                                                              CD ARG 367                                                                               39.617                                                                             26.227                                                                             59.483                                                                             1.00                                                                              39.84            1DLC2649                    ATOM  2526                                                                              NE ARG 367                                                                               39.715                                                                             27.236                                                                             60.538                                                                             1.00                                                                              46.62            1DLC2650                    ATOM  2527                                                                              CZ ARG 367                                                                               40.452                                                                             27.122                                                                             61.642                                                                             1.00                                                                              47.81            1DLC2651                    ATOM  2528                                                                              NH1                                                                               ARG 367                                                                               41.174                                                                             26.027                                                                             61.857                                                                             1.00                                                                              49.54            1DLC2652                    ATOM  2529                                                                              NH2                                                                               ARG 367                                                                               40.473                                                                             28.114                                                                             62.528                                                                             1.00                                                                              42.81            1DLC2653                    ATOM  2530                                                                              N  PRO 368                                                                               35.927                                                                             28.497                                                                             61.167                                                                             1.00                                                                              25.39            1DLC2654                    ATOM  2531                                                                              CA PRO 368                                                                               36.055                                                                             29.944                                                                             61.357                                                                             1.00                                                                              24.95            1DLC2655                    ATOM  2532                                                                              C  PRO 368                                                                               37.430                                                                             30.514                                                                             61.038                                                                             1.00                                                                              25.37            1DLC2656                    ATOM  2533                                                                              O  PRO 368                                                                               38.312                                                                             29.832                                                                             60.517                                                                             1.00                                                                              25.73            1DLC2657                    ATOM  2534                                                                              CB PRO 368                                                                               35.695                                                                             30.131                                                                             62.833                                                                             1.00                                                                              23.10            1DLC2658                    ATOM  2535                                                                              CG PRO 368                                                                               36.052                                                                             28.813                                                                             63.453                                                                             1.00                                                                              27.44            1DLC2659                    ATOM  2536                                                                              CD PRO 368                                                                               35.568                                                                             27.826                                                                             62.427                                                                             1.00                                                                              25.33            1DLC2660                    ATOM  2537                                                                              N  SER 369                                                                               37.582                                                                             31.800                                                                             61.301                                                                             1.00                                                                              25.94            1DLC2661                    ATOM  2538                                                                              CA SER 369                                                                               38.849                                                                             32.470                                                                             61.075                                                                             1.00                                                                              28.16            1DLC2662                    ATOM  2539                                                                              C  SER 369                                                                               39.857                                                                             31.953                                                                             62.126                                                                             1.00                                                                              30.36            1DLC2663                    ATOM  2540                                                                              O  SER 369                                                                               39.459                                                                             31.446                                                                             63.195                                                                             1.00                                                                              27.15            1DLC2664                    ATOM  2541                                                                              CB SER 369                                                                               38.647                                                                             33.983                                                                             61.205                                                                             1.00                                                                              28.25            1DLC2665                    ATOM  2542                                                                              OG SER 369                                                                               39.797                                                                             34.702                                                                             60.811                                                                             1.00                                                                              31.44            1DLC2666                    ATOM  2543                                                                              N  ILE 370                                                                               41.151                                                                             32.051                                                                             61.813                                                                             1.00                                                                              27.89            1DLC2667                    ATOM  2544                                                                              CA ILE 370                                                                               42.198                                                                             31.602                                                                             62.731                                                                             1.00                                                                              26.08            1DLC2668                    ATOM  2545                                                                              C  ILE 370                                                                               41.936                                                                             32.085                                                                             64.169                                                                             1.00                                                                              25.65            1DLC2669                    ATOM  2546                                                                              O  ILE 370                                                                               41.477                                                                             33.208                                                                             64.388                                                                             1.00                                                                              24.58            1DLC2670                    ATOM  2547                                                                              CB ILE 370                                                                               43.612                                                                             32.047                                                                             62.241                                                                             1.00                                                                              28.63            1DLC2671                    ATOM  2548                                                                              CG1                                                                               ILE 370                                                                               44.695                                                                             31.410                                                                             63.116                                                                             1.00                                                                              28.81            1DLC2672                    ATOM  2549                                                                              CG2                                                                               ILE 370                                                                               43.749                                                                             33.576                                                                             62.236                                                                             1.00                                                                              24.11            1DLC2673                    ATOM  2550                                                                              CD1                                                                               ILE 370                                                                               46.064                                                                             31.482                                                                             62.521                                                                             1.00                                                                              22.91            1DLC2674                    ATOM  2551                                                                              N  GLY 371                                                                               42.179                                                                             31.218                                                                             65.143                                                                             1.00                                                                              26.12            1DLC2675                    ATOM  2552                                                                              CA GLY 371                                                                               41.934                                                                             31.588                                                                             66.526                                                                             1.00                                                                              27.59            1DLC2676                    ATOM  2553                                                                              C  GLY 371                                                                               40.831                                                                             30.742                                                                             67.132                                                                             1.00                                                                              31.60            1DLC2677                    ATOM  2554                                                                              O  GLY 371                                                                               40.728                                                                             30.608                                                                             68.347                                                                             1.00                                                                              32.87            1DLC2678                    ATOM  2555                                                                              N  SER 372                                                                               39.973                                                                             30.198                                                                             66.279                                                                             1.00                                                                              34.07            1DLC2679                    ATOM  2556                                                                              CA SER 372                                                                               38.886                                                                             29.334                                                                             66.733                                                                             1.00                                                                              38.39            1DLC2680                    ATOM  2557                                                                              C  SER 372                                                                               38.918                                                                             28.050                                                                             65.926                                                                             1.00                                                                              42.67            1DLC2681                    ATOM  2558                                                                              O  SER 372                                                                               39.225                                                                             28.058                                                                             64.731                                                                             1.00                                                                              45.63            1DLC2682                    ATOM  2559                                                                              CB SER 372                                                                               37.522                                                                             30.000                                                                             66.553                                                                             1.00                                                                              37.68            1DLC2683                    ATOM  2560                                                                              OG SER 372                                                                               36.484                                                                             29.117                                                                             66.945                                                                             1.00                                                                              35.42            1DLC2684                    ATOM  2561                                                                              N  ASN 373                                                                               38.605                                                                             26.940                                                                             66.571                                                                             1.00                                                                              45.05            1DLC2685                    ATOM  2562                                                                              CA ASN 373                                                                               38.624                                                                             25.669                                                                             65.869                                                                             1.00                                                                              49.01            1DLC2686                    ATOM  2563                                                                              C  ASN 373                                                                               37.271                                                                             24.961                                                                             65.761                                                                             1.00                                                                              49.16            1DLC2687                    ATOM  2564                                                                              O  ASN 373                                                                               37.158                                                                             23.940                                                                             65.078                                                                             1.00                                                                              50.24            1DLC2688                    ATOM  2565                                                                              CB ASN 373                                                                               39.670                                                                             24.745                                                                             66.501                                                                             1.00                                                                              53.82            1DLC2689                    ATOM  2566                                                                              CG ASN 373                                                                               41.091                                                                             25.214                                                                             66.246                                                                             1.00                                                                              58.42            1DLC2690                    ATOM  2567                                                                              OD1                                                                               ASN 373                                                                               41.791                                                                             25.640                                                                             67.163                                                                             1.00                                                                              62.66            1DLC2691                    ATOM  2568                                                                              ND2                                                                               ASN 373                                                                               41.523                                                                             25.148                                                                             64.992                                                                             1.00                                                                              60.46            1DLC2692                    ATOM  2569                                                                              N  ASP 374                                                                               36.239                                                                             25.502                                                                             66.403                                                                             1.00                                                                              47.14            1DLC2693                    ATOM  2570                                                                              CA ASP 374                                                                               34.941                                                                             24.849                                                                             66.331                                                                             1.00                                                                              48.54            1DLC2694                    ATOM  2571                                                                              C  ASP 374                                                                               34.255                                                                             25.010                                                                             64.975                                                                             1.00                                                                              45.07            1DLC2695                    ATOM  2572                                                                              O  ASP 374                                                                               33.989                                                                             26.120                                                                             64.514                                                                             1.00                                                                              43.01            1DLC2696                    ATOM  2573                                                                              CB ASP 374                                                                               34.028                                                                             25.232                                                                             67.506                                                                             1.00                                                                              55.25            1DLC2697                    ATOM  2574                                                                              CG ASP 374                                                                               33.826                                                                             26.723                                                                             67.644                                                                             1.00                                                                              62.12            1DLC2698                    ATOM  2575                                                                              OD1                                                                               ASP 374                                                                               33.068                                                                             27.308                                                                             66.835                                                                             1.00                                                                              68.28            1DLC2699                    ATOM  2576                                                                              OD2                                                                               ASP 374                                                                               34.403                                                                             27.303                                                                             68.590                                                                             1.00                                                                              66.38            1DLC2700                    ATOM  2577                                                                              N  ILE 375                                                                               34.029                                                                             23.868                                                                             64.335                                                                             1.00                                                                              41.73            1DLC2701                    ATOM  2578                                                                              CA ILE 375                                                                               33.408                                                                             23.776                                                                             63.020                                                                             1.00                                                                              37.95            1DLC2702                    ATOM  2579                                                                              C  ILE 375                                                                               31.921                                                                             24.131                                                                             63.008                                                                             1.00                                                                              36.63            1DLC2703                    AT6M  2580                                                                              O  ILE 375                                                                               31.143                                                                             23.638                                                                             63.816                                                                             1.00                                                                              38.76            1DLC2704                    ATOM  2581                                                                              CB ILE 375                                                                               33.618                                                                             22.355                                                                             62.428                                                                             1.00                                                                              36.39            1DLC2705                    ATOM  2582                                                                              CG1                                                                               ILE 375                                                                               35.110                                                                             22.015                                                                             62.422                                                                             1.00                                                                              36.11            1DLC2706                    ATOM  2583                                                                              CG2                                                                               ILE 375                                                                               33.056                                                                             22.254                                                                             61.014                                                                             1.00                                                                              35.62            1DLC2707                    ATOM  2584                                                                              CD1                                                                               ILE 375                                                                               35.966                                                                             22.993                                                                             61.658                                                                             1.00                                                                              34.10            1DLC2708                    ATOM  2585                                                                              N  ILE 376                                                                               31.541                                                                             25.001                                                                             62.084                                                                             1.00                                                                              35.72            1DLC2709                    ATOM  2586                                                                              CA ILE 376                                                                               30.156                                                                             25.428                                                                             61.942                                                                             1.00                                                                              31.79            1DLC2710                    ATOM  2587                                                                              C  ILE 376                                                                               29.478                                                                             24.575                                                                             60.883                                                                             1.00                                                                              31.77            1DLC2711                    ATOM  2588                                                                              O  ILE 376                                                                               29.948                                                                             24.483                                                                             59.751                                                                             1.00                                                                              32.62            1DLC2712                    ATOM  2589                                                                              CB ILE 376                                                                               30.077                                                                             26.885                                                                             61.481                                                                             1.00                                                                              31.87            1DLC2713                    ATOM  2590                                                                              CG1                                                                               ILE 376                                                                               30.864                                                                             27.781                                                                             62.432                                                                             1.00                                                                              27.90            1DLC2714                    ATOM  2591                                                                              CG2                                                                               ILE 376                                                                               28.632                                                                             27.324                                                                             61.391                                                                             1.00                                                                              28.10            1DLC2715                    ATOM  2592                                                                              CD1                                                                               ILE 376                                                                               31.122                                                                             29.148                                                                             61.868                                                                             1.00                                                                              30.02            1DLC2716                    ATOM  2593                                                                              N  THR 377                                                                               28.390                                                                             23.921                                                                             61.250                                                                             1.00                                                                              31.76            1DLC2717                    ATOM  2594                                                                              CA THR 377                                                                               27.696                                                                             23.104                                                                             60.275                                                                             1.00                                                                              31.91            1DLC2718                    ATOM  2595                                                                              C  THR 377                                                                               26.337                                                                             23.687                                                                             59.972                                                                             1.00                                                                              31.49            1DLC2719                    ATOM  2596                                                                              O  THR 377                                                                               25.590                                                                             24.070                                                                             60.872                                                                             1.00                                                                              32.65            1DLC2720                    ATOM  2597                                                                              CB THR 377                                                                               27.577                                                                             21.653                                                                             60.711                                                                             1.00                                                                              32.50            1DLC2721                    ATOM  2598                                                                              OG1                                                                               THR 377                                                                               28.890                                                                             21.137                                                                             60.960                                                                             1.00                                                                              34.88            1DLC2722                    ATOM  2599                                                                              CG2                                                                               THR 377                                                                               26.937                                                                             20.833                                                                             59.601                                                                             1.00                                                                              36.51            1DLC2723                    ATOM  2600                                                                              N  SER 378                                                                               26.056                                                                             23.790                                                                             58.681                                                                             1.00                                                                              31.02            1DLC2724                    ATOM  2601                                                                              CA SER 378                                                                               24.813                                                                             24.351                                                                             58.166                                                                             1.00                                                                              30.69            1DLC2725                    ATOM  2602                                                                              C  SER 378                                                                               23.570                                                                             23.484                                                                             58.326                                                                             1.00                                                                              30.61            1DLC2726                    ATOM  2603                                                                              O  SER 378                                                                               23.648                                                                             22.276                                                                             58.573                                                                             1.00                                                                              32.66            1DLC2727                    ATOM  2604                                                                              CB SER 378                                                                               24.969                                                                             24.591                                                                             56.672                                                                             1.00                                                                              29.80            1DLC2728                    ATOM  2605                                                                              OG SER 378                                                                               24.957                                                                             23.342                                                                             56.002                                                                             1.00                                                                              24.82            1DLC2729                    ATOM  2606                                                                              N  PRO 379                                                                               22.392                                                                             24.105                                                                             58.200                                                                             1.00                                                                              30.39            1DLC2730                    ATOM  2607                                                                              CA PRO 379                                                                               21.155                                                                             23.332                                                                             58.313                                                                             1.00                                                                              29.82            1DLC2731                    ATOM  2608                                                                              C  PRO 379                                                                               21.130                                                                             22.476                                                                             57.042                                                                             1.00                                                                              29.81            1DLC2732                    ATOM  2609                                                                              O  PRO 379                                                                               21.967                                                                             22.660                                                                             56.154                                                                             1.00                                                                              31.85            1DLC2733                    ATOM  2610                                                                              CB PRO 379                                                                               20.076                                                                             24.413                                                                             58.234                                                                             1.00                                                                              28.69            1DLC2734                    ATOM  2611                                                                              CG PRO 379                                                                               20.761                                                                             25.632                                                                             58.763                                                                             1.00                                                                              29.56            1DLC2735                    ATOM  2612                                                                              CD PRO 379                                                                               22.107                                                                             25.547                                                                             58.115                                                                             1.00                                                                              30.05            1DLC2736                    ATOM  2613                                                                              N  PHE 380                                                                               20.206                                                                             21.535                                                                             56.941                                                                             1.00                                                                              28.23            1DLC2737                    ATOM  2614                                                                              CA PHE 380                                                                               20.154                                                                             20.740                                                                             55.727                                                                             1.00                                                                              27.04            1DLC2738                    ATOM  2615                                                                              C  PHE 380                                                                               19.513                                                                             21.568                                                                             54.606                                                                             1.00                                                                              26.98            1DLC2739                    ATOM  2616                                                                              O  PHE 380                                                                               18.578                                                                             22.335                                                                             54.850                                                                             1.00                                                                              29.48            1DLC2740                    ATOM  2617                                                                              CB PHE 380                                                                               19.381                                                                             19.435                                                                             55.938                                                                             1.00                                                                              25.05            1DLC2741                    ATOM  2618                                                                              CG PHE 380                                                                               19.383                                                                             18.545                                                                             54.731                                                                             1.00                                                                              24.11            1DLC2742                    ATOM  2619                                                                              CD1                                                                               PHE 380                                                                               20.527                                                                             17.846                                                                             54.377                                                                             1.00                                                                              20.89            1DLC2743                    ATOM  2620                                                                              CD2                                                                               PHE 380                                                                               18.268                                                                             18.467                                                                             53.903                                                                             1.00                                                                              21.40            1DLC2744                    ATOM  2621                                                                              CE1                                                                               PHE 380                                                                               20.566                                                                             17.089                                                                             53.216                                                                             1.00                                                                              20.66            1DLC2745                    ATOM  2622                                                                              CE2                                                                               PHE 380                                                                               18.300                                                                             17.714                                                                             52.742                                                                             1.00                                                                              22.67            1DLC2746                    ATOM  2623                                                                              CZ PHE 380                                                                               19.453                                                                             17.025                                                                             52.396                                                                             1.00                                                                              21.89            1DLC2747                    ATOM  2624                                                                              N  TYR 381                                                                               20.050                                                                             21.446                                                                             53.395                                                                             1.00                                                                              26.14            1DLC2748                    ATOM  2625                                                                              CA TYR 381                                                                               19.525                                                                             22.167                                                                             52.241                                                                             1.00                                                                              25.56            1DLC2749                    ATOM  2626                                                                              C  TYR 381                                                                               19.056                                                                             21.183                                                                             51.182                                                                             1.00                                                                              28.82            1DLC2750                    ATOM  2627                                                                              O  TYR 381                                                                               19.812                                                                             20.291                                                                             50.797                                                                             1.00                                                                              31.78            1DLC2751                    ATOM  2628                                                                              CB TYR 381                                                                               20.607                                                                             23.053                                                                             51.608                                                                             1.00                                                                              25.41            1DLC2752                    ATOM  2629                                                                              CG TYR 381                                                                               21.187                                                                             24.117                                                                             52.512                                                                             1.00                                                                              25.18            1DLC2753                    ATOM  2630                                                                              CD1                                                                               TYR 381                                                                               20.375                                                                             25.090                                                                             53.087                                                                             1.00                                                                              23.16            1DLC2754                    ATOM  2631                                                                              CD2                                                                               TYR 381                                                                               22.558                                                                             24.162                                                                             52.779                                                                             1.00                                                                              21.71            1DLC2755                    ATOM  2632                                                                              CE1                                                                               TYR 381                                                                               20.914                                                                             26.080                                                                             53.905                                                                             1.00                                                                              24.57            1DLC2756                    ATOM  2633                                                                              CE2                                                                               TYR 381                                                                               23.101                                                                             25.148                                                                             53.592                                                                             1.00                                                                              20.00            1DLC2757                    ATOM  2634                                                                              CZ TYR 381                                                                               22.277                                                                             26.102                                                                             54.153                                                                             1.00                                                                              20.22            1DLC2758                    ATOM  2635                                                                              OH TYR 381                                                                               22.797                                                                             27.071                                                                             54.980                                                                             1.00                                                                              21.73            1DLC2759                    ATOM  2636                                                                              N  GLY 382                                                                               17.828                                                                             21.358                                                                             50.696                                                                             1.00                                                                              30.75            1DLC2760                    ATOM  2637                                                                              CA GLY 382                                                                               17.307                                                                             20.495                                                                             49.646                                                                             1.00                                                                              29.98            1DLC2761                    ATOM  2638                                                                              C  GLY 382                                                                               16.603                                                                             19.230                                                                             50.093                                                                             1.00                                                                              32.07            1DLC2762                    ATOM  2639                                                                              O  GLY 382                                                                               15.939                                                                             19.219                                                                             51.126                                                                             1.00                                                                              34.65            1DLC2763                    ATOM  2640                                                                              N  ASN 383                                                                               16.765                                                                             18.157                                                                             49.325                                                                             1.00                                                                              31.65            1DLC2764                    ATOM  2641                                                                              CA ASN 383                                                                               16.123                                                                             16.877                                                                             49.632                                                                             1.00                                                                              31.34            1DLC2765                    ATOM  2642                                                                              C  ASN 383                                                                               17.023                                                                             15.758                                                                             50.136                                                                             1.00                                                                              29.92            1DLC2766                    ATOM  2643                                                                              O  ASN 383                                                                               18.083                                                                             15.493                                                                             49.567                                                                             1.00                                                                              28.55            1DLC2767                    ATOM  2644                                                                              CB ASN 383                                                                               15.346                                                                             16.373                                                                             48.417                                                                             1.00                                                                              32.90            1DLC2768                    ATOM  2645                                                                              CG ASN 383                                                                               13.928                                                                             16.892                                                                             48.383                                                                             1.00                                                                              33.10            1DLC2769                    ATOM  2646                                                                              OD1                                                                               ASN 383                                                                               13.267                                                                             16.978                                                                             49.412                                                                             1.00                                                                              34.94            1DLC2770                    ATOM  2647                                                                              ND2                                                                               ASN 383                                                                               13.453                                                                             17.242                                                                             47.203                                                                             1.00                                                                              33.54            1DLC2771                    ATOM  2648                                                                              N  LYS 384                                                                               16.566                                                                             15.070                                                                             51.179                                                                             1.00                                                                              30.21            1DLC2772                    ATOM  2649                                                                              CA LYS 384                                                                               17.318                                                                             13.959                                                                             51.755                                                                             1.00                                                                              30.37            1DLC2773                    ATOM  2650                                                                              C  LYS 384                                                                               17.691                                                                             12.931                                                                             50.696                                                                             1.00                                                                              29.47            1DLC2774                    ATOM  2651                                                                              O  LYS 384                                                                               17.039                                                                             12.806                                                                             49.666                                                                             1.00                                                                              30.67            1DLC2775                    ATOM  2652                                                                              CB LYS 384                                                                               16.538                                                                             13.283                                                                             52.877                                                                             1.00                                                                              31.48            1DLC2776                    ATOM  2653                                                                              CG LYS 384                                                                               16.309                                                                             14.156                                                                             54.090                                                                             1.00                                                                              37.12            1DLC2777                    ATOM  2654                                                                              CD LYS 384                                                                               17.594                                                                             14.459                                                                             54.835                                                                             1.00                                                                              36.68            1DLC2778                    ATOM  2655                                                                              CE LYS 384                                                                               17.275                                                                             15.123                                                                             56.166                                                                             1.00                                                                              43.15            1DLC2779                    ATOM  2656                                                                              NZ LYS 384                                                                               18.485                                                                             15.319                                                                             57.010                                                                             1.00                                                                              50.78            1DLC2780                    ATOM  2657                                                                              N  SER 385                                                                               18.736                                                                             12.174                                                                             50.977                                                                             1.00                                                                              31.31            1DLC2781                    ATOM  2658                                                                              CA SER 385                                                                               19.230                                                                             11.191                                                                             50.033                                                                             1.00                                                                              33.17            1DLC2782                    ATOM  2659                                                                              C  SER 385                                                                               18.391                                                                             9.923                                                                              49.935                                                                             1.00                                                                              34.75            1DLC2783                    ATOM  2660                                                                              O  SER 385                                                                               17.817                                                                             9.464                                                                              50.921                                                                             1.00                                                                              35.39            1DLC2784                    ATOM  2661                                                                              CB SER 385                                                                               20.672                                                                             10.821                                                                             50.401                                                                             1.00                                                                              31.08            1DLC2785                    ATOM  2662                                                                              OG SER 385                                                                               21.444                                                                             10.511                                                                             49.254                                                                             1.00                                                                              29.79            1DLC2786                    ATOM  2663                                                                              N  SER 386                                                                               18.249                                                                             9.425                                                                              48.714                                                                             1.00                                                                              36.92            1DLC2787                    ATOM  2664                                                                              CA SER 386                                                                               17.559                                                                             8.158                                                                              48.476                                                                             1.00                                                                              39.89            1DLC2788                    ATOM  2665                                                                              C  SER 386                                                                               18.713                                                                             7.175                                                                              48.234                                                                             1.00                                                                              41.41            1DLC2789                    ATOM  2666                                                                              O  SER 386                                                                               18.573                                                                             5.965                                                                              48.395                                                                             1.00                                                                              45.84            1DLC2790                    ATOM  2667                                                                              CB SER 386                                                                               16.666                                                                             8.215                                                                              47.233                                                                             1.00                                                                              38.56            1DLC2791                    ATOM  2668                                                                              OG SER 386                                                                               17.424                                                                             8.118                                                                              46.036                                                                             1.00                                                                              38.63            1DLC2792                    ATOM  2669                                                                              N  GLU 387                                                                               19.862                                                                             7.730                                                                              47.857                                                                             1.00                                                                              39.62            1DLC2793                    ATOM  2670                                                                              CA GLU 387                                                                               21.067                                                                             6.957                                                                              47.593                                                                             1.00                                                                              38.96            1DLC2794                    ATOM  2671                                                                              C  GLU 387                                                                               22.112                                                                             7.171                                                                              48.694                                                                             1.00                                                                              37.55            1DLC2795                    ATOM  2672                                                                              O  GLU 387                                                                               21.908                                                                             7.960                                                                              49.618                                                                             1.00                                                                              37.34            1DLC2796                    ATOM  2673                                                                              CB GLU 387                                                                               21.653                                                                             7.387                                                                              46.250                                                                             1.00                                                                              41.28            1DLC2797                    ATOM  2674                                                                              CG GLU 387                                                                               20.667                                                                             7.310                                                                              45.114                                                                             1.00                                                                              48.83            1DLC2798                    ATOM  2675                                                                              CD GLU 387                                                                               19.985                                                                             5.962                                                                              45.046                                                                             1.00                                                                              54.03            1DLC2799                    ATOM  2676                                                                              OE1                                                                               GLU 387                                                                               20.706                                                                             4.937                                                                              45.061                                                                             1.00                                                                              55.83            1DLC2800                    ATOM  2677                                                                              OE2                                                                               GLU 387                                                                               18.732                                                                             5.928                                                                              44.997                                                                             1.00                                                                              55.98            1DLC2801                    ATOM  2678                                                                              N  PRO 388                                                                               23.230                                                                             6.438                                                                              48.632                                                                             1.00                                                                              36.30            1DLC2802                    ATOM  2679                                                                              CA PRO 388                                                                               24.279                                                                             6.593                                                                              49.645                                                                             1.00                                                                              35.40            1DLC2803                    ATOM  2680                                                                              C  PRO 388                                                                               24.950                                                                             7.981                                                                              49.624                                                                             1.00                                                                              34.68            1DLC2804                    ATOM  2681                                                                              O  PRO 388                                                                               25.396                                                                             8.486                                                                              48.603                                                                             1.00                                                                              33.48            1DLC2805                    ATOM  2682                                                                              CB PRO 388                                                                               25.278                                                                             5.503                                                                              49.261                                                                             1.00                                                                              35.55            1DLC2806                    ATOM  2683                                                                              CG PRO 388                                                                               24.406                                                                             4.448                                                                              48.677                                                                             1.00                                                                              36.31            1DLC2807                    ATOM  2684                                                                              CD PRO 388                                                                               23.481                                                                             5.245                                                                              47.804                                                                             1.00                                                                              35.19            1DLC2808                    ATOM  2685                                                                              N  VAL 389                                                                               25.025                                                                             8.573                                                                              50.826                                                                             1.00                                                                              31.70            1DLC2809                    ATOM  2686                                                                              CA VAL 389                                                                               25.640                                                                             9.878                                                                              51.034                                                                             1.00                                                                              33.25            1DLC2810                    ATOM  2687                                                                              C  VAL 389                                                                               27.136                                                                             9.922                                                                              50.661                                                                             1.00                                                                              34.25            1DLC2811                    ATOM  2688                                                                              O  VAL 389                                                                               27.852                                                                             8.928                                                                              50.800                                                                             1.00                                                                              35.26            1DLC2812                    ATOM  2689                                                                              CB VAL 389                                                                               25.459                                                                             10.293                                                                             52.516                                                                             1.00                                                                              31.82            1DLC2813                    ATOM  2690                                                                              CG1                                                                               VAL 389                                                                               26.378                                                                             11.431                                                                             52.887                                                                             1.00                                                                              34.96            1DLC2814                    ATOM  2691                                                                              CG2                                                                               VAL 389                                                                               24.021                                                                             10.687                                                                             52.761                                                                             1.00                                                                              34.70            1DLC2815                    ATOM  2692                                                                              N  GLN 390                                                                               27.589                                                                             11.069                                                                             50.159                                                                             1.00                                                                              34.02            1DLC2816                    ATOM  2693                                                                              CA GLN 390                                                                               28.994                                                                             11.268                                                                             49.798                                                                             1.00                                                                              34.03            1DLC2817                    ATOM  2694                                                                              C  GLN 390                                                                               29.556                                                                             12.458                                                                             50.567                                                                             1.00                                                                              34.94            1DLC2818                    ATOM  2695                                                                              O  GLN 390                                                                               28.929                                                                             13.511                                                                             50.642                                                                             1.00                                                                              37.45            1DLC2819                    ATOM  2696                                                                              CB GLN 390                                                                               29.156                                                                             11.502                                                                             48.298                                                                             1.00                                                                              30.86            1DLC2820                    ATOM  2697                                                                              CG GLN 390                                                                               28.968                                                                             10.258                                                                             47.478                                                                             1.00                                                                              34.90            1DLC2821                    ATOM  2698                                                                              CD GLN 390                                                                               28.993                                                                             10.520                                                                             45.985                                                                             1.00                                                                              37.84            1DLC2822                    ATOM  2699                                                                              OE1                                                                               GLN 390                                                                               29.887                                                                             11.189                                                                             45.467                                                                             1.00                                                                              39.97            1DLC2823                    ATOM  2700                                                                              NE2                                                                               GLN 390                                                                               28.011                                                                             9.982                                                                              45.282                                                                             1.00                                                                              36.71            1DLC2824                    ATOM  2701                                                                              N  ASN 391                                                                               30.735                                                                             12.285                                                                             51.150                                                                             1.00                                                                              36.13            1DLC2825                    ATOM  2702                                                                              CA ASN 391                                                                               31.364                                                                             13.350                                                                             51.918                                                                             1.00                                                                              35.90            1DLC2826                    ATOM  2703                                                                              C  ASN 391                                                                               32.749                                                                             13.684                                                                             51.399                                                                             1.00                                                                              34.56            1DLC2827                    ATOM  2704                                                                              O  ASN 391                                                                               33.568                                                                             12.796                                                                             51.197                                                                             1.00                                                                              36.19            1DLC2828                    ATOM  2705                                                                              CB ASN 391                                                                               31.471                                                                             12.951                                                                             53.389                                                                             1.00                                                                              38.72            1DLC2829                    ATOM  2706                                                                              CG ASN 391                                                                               30.122                                                                             12.680                                                                             54.021                                                                             1.00                                                                              46.12            1DLC2830                    ATOM  2707                                                                              OD1                                                                               ASN 391                                                                               29.101                                                                             13.193                                                                             53.576                                                                             1.00                                                                              54.69            1DLC2831                    ATOM  2708                                                                              ND2                                                                               LEU 392                                                                               30.108                                                                             11.871                                                                             55.065                                                                             1.00                                                                              48.42            1DLC2832                    ATOM  2709                                                                              N  LEU 392                                                                               32.992                                                                             14.965                                                                             51.149                                                                             1.00                                                                              35.38            1DLC2833                    ATOM  2710                                                                              CA LEU 392                                                                               34.302                                                                             15.428                                                                             50.690                                                                             1.00                                                                              31.94            1DLC2834                    ATOM  2711                                                                              C  LEU 392                                                                               34.846                                                                             16.361                                                                             51.758                                                                             1.00                                                                              32.63            1DLC2835                    ATOM  2712                                                                              O  LEU 392                                                                               34.106                                                                             17.196                                                                             52.280                                                                             1.00                                                                              35.13            1DLC2836                    ATOM  2713                                                                              CB LEU 392                                                                               34.192                                                                             16.194                                                                             49.369                                                                             1.00                                                                              27.68            1DLC2837                    ATOM  2714                                                                              CG LEU 392                                                                               33.624                                                                             15.448                                                                             48.164                                                                             1.00                                                                              26.82            1DLC2838                    ATOM  2715                                                                              CD1                                                                               LEU 392                                                                               33.756                                                                             16.283                                                                             46.906                                                                             1.00                                                                              26.78            1DLC2839                    ATOM  2716                                                                              CD2                                                                               LEU 392                                                                               34.365                                                                             14.155                                                                             47.987                                                                             1.00                                                                              29.40            1DLC2840                    ATOM  2717                                                                              N  GLU 393                                                                               36.098                                                                             16.162                                                                             52.157                                                                             1.00                                                                              34.76            1DLC2841                    ATOM  2718                                                                              CA GLU 393                                                                               36.721                                                                             17.039                                                                             53.150                                                                             1.00                                                                              34.99            1DLC2842                    ATOM  2719                                                                              C  GLU 393                                                                               37.754                                                                             17.931                                                                             52.477                                                                             1.00                                                                              33.60            1DLC2843                    ATOM  2720                                                                              O  GLU 393                                                                               38.398                                                                             17.522                                                                             51.510                                                                             1.00                                                                              27.84            1DLC2844                    ATOM  2721                                                                              CB GLU 393                                                                               37.371                                                                             16.246                                                                             54.273                                                                             1.00                                                                              41.28            1DLC2845                    ATOM  2722                                                                              CG GLU 393                                                                               36.404                                                                             15.790                                                                             55.338                                                                             1.00                                                                              49.72            1DLC2846                    ATOM  2723                                                                              CD GLU 393                                                                               36.135                                                                             14.297                                                                             55.306                                                                             1.00                                                                              57.23            1DLC2847                    ATOM  2724                                                                              DE1                                                                               GLU 393                                                                               36.653                                                                             13.603                                                                             54.396                                                                             1.00                                                                              62.82            1DLC2848                    ATOM  2725                                                                              OE2                                                                               GLU 393                                                                               35.401                                                                             13.814                                                                             56.200                                                                             1.00                                                                              61.57            1DLC2849                    ATOM  2726                                                                              N  PHE 394                                                                               37.912                                                                             19.148                                                                             52.989                                                                             1.00                                                                              35.60            1DLC2850                    ATOM  2727                                                                              CA PHE 394                                                                               38.851                                                                             20.104                                                                             52.393                                                                             1.00                                                                              37.09            1DLC2851                    ATOM  2728                                                                              C  PHE 394                                                                               39.931                                                                             20.691                                                                             53.302                                                                             1.00                                                                              41.43            1DLC2852                    ATOM  2729                                                                              O  PHE 394                                                                               40.735                                                                             21.489                                                                             52.847                                                                             1.00                                                                              42.91            1DLC2853                    ATOM  2730                                                                              CB PHE 394                                                                               38.069                                                                             21.238                                                                             51.721                                                                             1.00                                                                              29.33            1DLC2854                    ATOM  2731                                                                              CG PHE 394                                                                               37.104                                                                             20.756                                                                             50.682                                                                             1.00                                                                              28.27            1DLC2855                    ATOM  2732                                                                              CD1                                                                               PHE 394                                                                               37.521                                                                             20.549                                                                             49.369                                                                             1.00                                                                              26.99            1DLC2856                    ATOM  2733                                                                              CD2                                                                               PHE 394                                                                               35.792                                                                             20.448                                                                             51.021                                                                             1.00                                                                              26.84            1DLC2857                    ATOM  2734                                                                              CE1                                                                               PHE 394                                                                               36.648                                                                             20.037                                                                             48.411                                                                             1.00                                                                              24.88            1DLC2858                    ATOM  2735                                                                              CE2                                                                               PHE 394                                                                               34.911                                                                             19.935                                                                             50.067                                                                             1.00                                                                              26.52            1DLC2859                    ATOM  2736                                                                              CZ PHE 394                                                                               35.342                                                                             19.730                                                                             48.760                                                                             1.00                                                                              25.09            1DLC2860                    ATOM  2737                                                                              N  ASN 395                                                                               39.973                                                                             20.256                                                                             54.561                                                                             1.00                                                                              45.12            1DLC2861                    ATOM  2738                                                                              CA ASN 395                                                                               40.939                                                                             20.741                                                                             55.563                                                                             1.00                                                                              51.55            1DLC2862                    ATOM  2739                                                                              C  ASN 395                                                                               42.208                                                                             21.432                                                                             55.023                                                                             1.00                                                                              53.27            1DLC2863                    ATOM  2740                                                                              O  ASN 395                                                                               43.197                                                                             20.769                                                                             54.699                                                                             1.00                                                                              57.04            1DLC2864                    ATOM  2741                                                                              CB ASN 395                                                                               41.358                                                                             19.590                                                                             56.489                                                                             1.00                                                                              57.57            1DLC2865                    ATOM  2742                                                                              CG ASN 395                                                                               40.201                                                                             18.671                                                                             56.848                                                                             1.00                                                                              64.16            1DLC2866                    ATOM  2743                                                                              OD1                                                                               ASN 395                                                                               39.360                                                                             19.002                                                                             57.684                                                                             1.00                                                                              69.45            1DLC2867                    ATOM  2744                                                                              ND2                                                                               ASN 395                                                                               40.144                                                                             17.516                                                                             56.202                                                                             1.00                                                                              66.55            1DLC2868                    ATOM  2745                                                                              N  GLY 396                                                                               42.167                                                                             22.756                                                                             54.897                                                                             1.00                                                                              52.24            1DLC2869                    ATOM  2746                                                                              CA GLY 396                                                                               43.331                                                                             23.488                                                                             54.409                                                                             1.00                                                                              52.60            1DLC2870                    ATOM  2747                                                                              C  GLY 396                                                                               43.473                                                                             23.670                                                                             52.898                                                                             1.00                                                                              51.64            1DLC2871                    ATOM  2748                                                                              O  GLY 396                                                                               44.241                                                                             24.524                                                                             52.432                                                                             1.00                                                                              55.32            1DLC2872                    ATOM  2749                                                                              N  GLU 397                                                                               42.812                                                                             22.805                                                                             52.137                                                                             1.00                                                                              46.45            1DLC2873                    ATOM  2750                                                                              CA GLU 397                                                                               42.820                                                                             22.868                                                                             50.681                                                                             1.00                                                                              40.85            1DLC2874                    ATOM  2751                                                                              C  GLU 397                                                                               42.048                                                                             24.096                                                                             50.190                                                                             1.00                                                                              36.96            1DLC2875                    ATOM  2752                                                                              O  GLU 397                                                                               41.064                                                                             24.510                                                                             50.801                                                                             1.00                                                                              36.76            1DLC2876                    ATOM  2753                                                                              CB GLU 397                                                                               42.132                                                                             21.628                                                                             50.108                                                                             1.00                                                                              42.90            1DLC2877                    ATOM  2754                                                                              CG GLU 397                                                                               42.655                                                                             20.311                                                                             50.629                                                                             1.00                                                                              46.38            1DLC2878                    ATOM  2755                                                                              CD GLU 397                                                                               44.049                                                                             19.997                                                                             50.125                                                                             1.00                                                                              50.24            1DLC2879                    ATOM  2756                                                                              OE1                                                                               GLU 397                                                                               44.319                                                                             20.217                                                                             48.920                                                                             1.00                                                                              48.15            1DLC2880                    ATOM  2757                                                                              OE2                                                                               GLU 397                                                                               44.873                                                                             19.519                                                                             50.939                                                                             1.00                                                                              54.59            1DLC2881                    ATOM  2758                                                                              N  LYS 398                                                                               42.488                                                                             24.677                                                                             49.084                                                                             1.00                                                                              32.97            1DLC2882                    ATOM  2759                                                                              CA LYS 398                                                                               41.793                                                                             25.819                                                                             48.515                                                                             1.00                                                                              29.63            1DLC2883                    ATOM  2760                                                                              C  LYS 398                                                                               41.163                                                                             25.405                                                                             47.194                                                                             1.00                                                                              28.78            1DLC2884                    ATOM  2761                                                                              O  LYS 398                                                                               41.874                                                                             25.081                                                                             46.234                                                                             1.00                                                                              28.04            1DLC2885                    ATOM  2762                                                                              CB LYS 398                                                                               42.749                                                                             26.983                                                                             48.303                                                                             1.00                                                                              30.66            1DLC2886                    ATOM  2763                                                                              CG LYS 398                                                                               43.278                                                                             27.560                                                                             49.591                                                                             1.00                                                                              36.26            1DLC2887                    ATOM  2764                                                                              CD LYS 398                                                                               44.378                                                                             28.545                                                                             49.306                                                                             1.00                                                                              42.44            1DLC2888                    ATOM  2765                                                                              CE LYS 398                                                                               44.979                                                                             29.085                                                                             50.580                                                                             1.00                                                                              44.63            1DLC2889                    ATOM  2766                                                                              NZ LYS 398                                                                               46.179                                                                             29.912                                                                             50.258                                                                             1.00                                                                              52.09            1DLC2890                    ATOM  2767                                                                              N  VAL 399                                                                               39.830                                                                             25.374                                                                             47.162                                                                             1.00                                                                              25.99            1DLC2891                    ATOM  2768                                                                              CA VAL 399                                                                               39.097                                                                             24.992                                                                             45.960                                                                             1.00                                                                              22.58            1DLC2892                    ATOM  2769                                                                              C  VAL 399                                                                               39.068                                                                             26.170                                                                             45.001                                                                             1.00                                                                              20.61            1DLC2893                    ATOM  2770                                                                              O  VAL 399                                                                               38.400                                                                             27.169                                                                             45.238                                                                             1.00                                                                              22.09            1DLC2894                    ATOM  2771                                                                              CB VAL 399                                                                               37.663                                                                             24.509                                                                             46.293                                                                             1.00                                                                              24.43            1DLC2895                    ATOM  2772                                                                              CG1                                                                               VAL 399                                                                               36.933                                                                             24.069                                                                             45.021                                                                             1.00                                                                              21.92            1DLC2896                    ATOM  2773                                                                              CG2                                                                               VAL 399                                                                               37.726                                                                             23.355                                                                             47.281                                                                             1.00                                                                              22.57            1DLC2897                    ATOM  2774                                                                              N  TYR 400                                                                               39.840                                                                             26.057                                                                             43.931                                                                             1.00                                                                              19.64            1DLC2898                    ATOM  2775                                                                              CA TYR 400                                                                               39.937                                                                             27.125                                                                             42.952                                                                             1.00                                                                              18.79            1DLC2899                    ATOM  2776                                                                              C  TYR 400                                                                               39.132                                                                             26.885                                                                             41.684                                                                             1.00                                                                              20.30            1DLC2900                    ATOM  2777                                                                              O  TYR 400                                                                               39.118                                                                             27.714                                                                             40.769                                                                             1.00                                                                              15.31            1DLC2901                    ATOM  2778                                                                              CB TYR 400                                                                               41.408                                                                             27.404                                                                             42.624                                                                             1.00                                                                              19.27            1DLC2902                    ATOM  2779                                                                              CG TYR 400                                                                               42.148                                                                             26.253                                                                             42.000                                                                             1.00                                                                              16.63            1DLC2903                    ATOM  2780                                                                              CD1                                                                               TYR 400                                                                               42.774                                                                             25.290                                                                             42.791                                                                             1.00                                                                              16.65            1DLC2904                    ATOM  2781                                                                              CD2                                                                               TYR 400                                                                               42.234                                                                             26.134                                                                             40.616                                                                             1.00                                                                              18.17            1DLC2905                    ATOM  2782                                                                              CE1                                                                               TYR 400                                                                               43.477                                                                             24.226                                                                             42.215                                                                             1.00                                                                              19.68            1DLC2906                    ATOM  2783                                                                              CE2                                                                               TYR 400                                                                               42.929                                                                             25.080                                                                             40.026                                                                             1.00                                                                              23.20            1DLC2907                    ATOM  2784                                                                              CZ TYR 400                                                                               43.549                                                                             24.127                                                                             40.830                                                                             1.00                                                                              21.51            1DLC2908                    ATOM  2785                                                                              OH TYR 400                                                                               44.227                                                                             23.084                                                                             40.235                                                                             1.00                                                                              22.85            1DLC2909                    ATOM  2786                                                                              N  ARG 401                                                                               38.461                                                                             25.742                                                                             41.632                                                                             1.00                                                                              20.95            1DLC2910                    ATOM  2787                                                                              CA ARG 401                                                                               37.640                                                                             25.419                                                                             40.484                                                                             1.00                                                                              21.84            1DLC2911                    ATOM  2788                                                                              C  ARG 401                                                                               36.590                                                                             24.354                                                                             40.770                                                                             1.00                                                                              23.36            1DLC2912                    ATOM  2789                                                                              O  ARG 401                                                                               36.748                                                                             23.510                                                                             41.658                                                                             1.00                                                                              24.04            1DLC2913                    ATOM  2790                                                                              CB ARG 401                                                                               38.508                                                                             24.984                                                                             39.312                                                                             1.00                                                                              24.53            1DLC2914                    ATOM  2791                                                                              CG ARG 401                                                                               37.822                                                                             25.117                                                                             37.966                                                                             1.00                                                                              24.58            1DLC2915                    ATOM  2792                                                                              CD ARG 401                                                                               38.656                                                                             24.464                                                                             36.894                                                                             1.00                                                                              25.33            1DLC2916                    ATOM  2793                                                                              NE ARG 401                                                                               38.195                                                                             24.815                                                                             35.558                                                                             1.00                                                                              28.66            1DLC2917                    ATOM  2794                                                                              CZ ARG 401                                                                               38.722                                                                             24.326                                                                             34.444                                                                             1.00                                                                              28.89            1DLC2918                    ATOM  2795                                                                              NH1                                                                               ARG 401                                                                               39.724                                                                             23.463                                                                             34.506                                                                             1.00                                                                              35.25            1DLC2919                    ATOM  2796                                                                              NH2                                                                               ARG 401                                                                               38.273                                                                             24.723                                                                             33.268                                                                             1.00                                                                              27.33            1DLC2920                    ATOM  2797                                                                              N  ALA 402                                                                               35.492                                                                             24.450                                                                             40.035                                                                             1.00                                                                              21.33            1DLC2921                    ATOM  2798                                                                              CA ALA 402                                                                               34.384                                                                             23.514                                                                             40.135                                                                             1.00                                                                              21.93            1DLC2922                    ATOM  2799                                                                              C  ALA 402                                                                               33.763                                                                             23.383                                                                             38.747                                                                             1.00                                                                              23.71            1DLC2923                    ATOM  2800                                                                              O  ALA 402                                                                               33.400                                                                             24.385                                                                             38.116                                                                             1.00                                                                              27.23            1DLC2924                    ATOM  2801                                                                              CB ALA 402                                                                               33.358                                                                             24.003                                                                             41.137                                                                             1.00                                                                              21.05            1DLC2925                    ATOM  2802                                                                              N  VAL 403                                                                               33.751                                                                             22.164                                                                             38.225                                                                             1.00                                                                              23.23            1DLC2926                    ATOM  2803                                                                              CA VAL 403                                                                               33.173                                                                             21.907                                                                             36.910                                                                             1.00                                                                              24.12            1DLC2927                    ATOM  2804                                                                              C  VAL 403                                                                               32.056                                                                             20.874                                                                             37.081                                                                             1.00                                                                              25.85            1DLC2928                    ATOM  2805                                                                              O  VAL 403                                                                               32.241                                                                             19.841                                                                             37.747                                                                             1.00                                                                              26.19            1DLC2929                    ATOM  2806                                                                              CB VAL 403                                                                               34.235                                                                             21.401                                                                             35.916                                                                             1.00                                                                              23.95            1DLC2930                    ATOM  2807                                                                              CG1                                                                               VAL 403                                                                               33.631                                                                             21.290                                                                             34.525                                                                             1.00                                                                              19.01            1DLC2931                    ATOM  2808                                                                              CG2                                                                               VAL 403                                                                               35.440                                                                             22.342                                                                             35.910                                                                             1.00                                                                              23.88            1DLC2932                    ATOM  2809                                                                              N  ALA 404                                                                               30.902                                                                             21.146                                                                             36.478                                                                             1.00                                                                              23.02            1DLC2933                    ATOM  2810                                                                              CA ALA 404                                                                               29.754                                                                             20.263                                                                             36.631                                                                             1.00                                                                              19.31            1DLC2934                    ATOM  2811                                                                              C  ALA 404                                                                               29.100                                                                             19.659                                                                             35.390                                                                             1.00                                                                              18.96            1DLC2935                    ATOM  2812                                                                              O  ALA 404                                                                               29.104                                                                             20.236                                                                             34.299                                                                             1.00                                                                              19.34            1DLC2936                    ATOM  2813                                                                              CB ALA 404                                                                               28.697                                                                             20.966                                                                             37.477                                                                             1.00                                                                              17.73            1DLC2937                    ATOM  2814                                                                              N  ASN 405                                                                               28.526                                                                             18.480                                                                             35.596                                                                             1.00                                                                              19.71            1DLC2938                    ATOM  2815                                                                              CA ASN 405                                                                               27.792                                                                             17.748                                                                             34.574                                                                             1.00                                                                              21.57            1DLC2939                    ATOM  2816                                                                              C  ASN 405                                                                               26.322                                                                             17.840                                                                             34.955                                                                             1.00                                                                              21.86            1DLC2940                    ATOM  2817                                                                              O  ASN 405                                                                               25.963                                                                             17.847                                                                             36.143                                                                             1.00                                                                              20.98            1DLC2941                    ATOM  2818                                                                              CB ASN 405                                                                               28.151                                                                             16.256                                                                             34.582                                                                             1.00                                                                              24.99            1DLC2942                    ATOM  2819                                                                              CG ASN 405                                                                               29.564                                                                             15.985                                                                             34.146                                                                             1.00                                                                              28.98            1DLC2943                    ATOM  2820                                                                              OD1                                                                               ASN 405                                                                               30.513                                                                             16.496                                                                             34.730                                                                             1.00                                                                              36.18            1DLC2944                    ATOM  2821                                                                              ND2                                                                               ASN 405                                                                               29.720                                                                             15.150                                                                             33.136                                                                             1.00                                                                              28.22            1DLC2945                    ATOM  2822                                                                              N  THR 406                                                                               25.463                                                                             17.927                                                                             33.957                                                                             1.00                                                                              21.73            1DLC2946                    ATOM  2823                                                                              CA THR 406                                                                               24.032                                                                             17.947                                                                             34.231                                                                             1.00                                                                              25.13            1DLC2947                    ATOM  2824                                                                              C  THR 406                                                                               23.374                                                                             16.983                                                                             33.257                                                                             1.00                                                                              26.31            1DLC2948                    ATOM  2825                                                                              O  THR 406                                                                               23.974                                                                             16.607                                                                             32.242                                                                             1.00                                                                              26.28            1DLC2949                    ATOM  2826                                                                              CB THR 406                                                                               23.390                                                                             19.362                                                                             34.089                                                                             1.00                                                                              24.14            1DLC2950                    ATOM  2827                                                                              OG1                                                                               THR 406                                                                               23.651                                                                             19.889                                                                             32.785                                                                             1.00                                                                              25.97            1DLC2951                    ATOM  2828                                                                              CG2                                                                               THR 406                                                                               23.911                                                                             20.324                                                                             35.163                                                                             1.00                                                                              20.04            1DLC2952                    ATOM  2829                                                                              N  ASN 407                                                                               22.185                                                                             16.509                                                                             33.603                                                                             1.00                                                                              27.43            1DLC2953                    ATOM  2830                                                                              CA ASN 407                                                                               21.474                                                                             15.608                                                                             32.706                                                                             1.00                                                                              27.11            1DLC2954                    ATOM  2831                                                                              C  ASN 407                                                                               19.981                                                                             15.902                                                                             32.722                                                                             1.00                                                                              25.60            1DLC2955                    ATOM  2832                                                                              O  ASN 407                                                                               19.478                                                                             16.551                                                                             33.637                                                                             1.00                                                                              24.05            1DLC2956                    ATOM  2833                                                                              CB ASN 407                                                                               21.750                                                                             14.141                                                                             33.059                                                                             1.00                                                                              25.28            1DLC2957                    ATOM  2834                                                                              CG ASN 407                                                                               21.683                                                                             13.226                                                                             31.842                                                                             1.00                                                                              22.24            1DLC2958                    ATOM  2835                                                                              OD1                                                                               ASN 407                                                                               21.389                                                                             13.665                                                                             30.730                                                                             1.00                                                                              19.56            1DLC2959                    ATOM  2836                                                                              ND2                                                                               ASN 407                                                                               21.969                                                                             11.955                                                                             32.047                                                                             1.00                                                                              24.80            1DLC2960                    ATOM  2837                                                                              N  LEU 408                                                                               19.283                                                                             15.447                                                                             31.692                                                                             1.00                                                                              25.59            1DLC2961                    ATOM  2838                                                                              CA LEU 408                                                                               17.852                                                                             15.673                                                                             31.604                                                                             1.00                                                                              27.24            1DLC2962                    ATOM  2839                                                                              C  LEU 408                                                                               17.090                                                                             14.488                                                                             31.024                                                                             1.00                                                                              27.97            1DLC2963                    ATOM  2840                                                                              O  LEU 408                                                                               17.607                                                                             13.731                                                                             30.205                                                                             1.00                                                                              29.46            1DLC2964                    ATOM  2841                                                                              CB LEU 408                                                                               17.561                                                                             16.945                                                                             30.790                                                                             1.00                                                                              28.54            1DLC2965                    ATOM  2842                                                                              CG LEU 408                                                                               17.883                                                                             17.006                                                                             29.289                                                                             1.00                                                                              28.16            1DLC2966                    ATOM  2843                                                                              CD1                                                                               LEU 408                                                                               16.710                                                                             16.462                                                                             28.507                                                                             1.00                                                                              31.12            1DLC2967                    ATOM  2844                                                                              CD2                                                                               LEU 408                                                                               18.137                                                                             18.439                                                                             28.859                                                                             1.00                                                                              25.06            1DLC2968                    ATOM  2845                                                                              N  ALA 409                                                                               15.863                                                                             14.319                                                                             31.489                                                                             1.00                                                                              27.95            1DLC2969                    ATOM  2846                                                                              CA ALA 409                                                                               14.990                                                                             13.263                                                                             31.011                                                                             1.00                                                                              26.71            1DLC2970                    ATOM  2847                                                                              C  ALA 409                                                                               13.750                                                                             13.974                                                                             30.501                                                                             1.00                                                                              26.39            1DLC2971                    ATOM  2848                                                                              O  ALA 409                                                                               13.185                                                                             14.819                                                                             31.197                                                                             1.00                                                                              27.94            1DLC2972                    ATOM  2849                                                                              CB ALA 409                                                                               14.628                                                                             12.317                                                                             32.145                                                                             1.00                                                                              25.33            1DLC2973                    ATOM  2850                                                                              N  VAL 410                                                                               13.376                                                                             13.701                                                                             29.259                                                                             1.00                                                                              26.74            1DLC2974                    ATOM  2851                                                                              CA VAL 410                                                                               12.189                                                                             14.312                                                                             28.670                                                                             1.00                                                                              27.20            1DLC2975                    ATOM  2852                                                                              C  VAL 410                                                                               10.956                                                                             13.404                                                                             28.802                                                                             1.00                                                                              28.76            1DLC2976                    ATOM  2853                                                                              O  VAL 410                                                                               10.885                                                                             12.345                                                                             28.179                                                                             1.00                                                                              31.07            1DLC2977                    ATOM  2854                                                                              CB VAL 410                                                                               12.419                                                                             14.650                                                                             27.183                                                                             1.00                                                                              27.70            1DLC2978                    ATOM  2855                                                                              CG1                                                                               VAL 410                                                                               11.162                                                                             15.238                                                                             26.567                                                                             1.00                                                                              25.34            1DLC2979                    ATOM  2856                                                                              CG2                                                                               VAL 410                                                                               13.561                                                                             15.627                                                                             27.050                                                                             1.00                                                                              28.45            1DLC2980                    ATOM  2857                                                                              N  TRP 411                                                                               10.027                                                                             13.792                                                                             29.669                                                                             1.00                                                                              28.92            1DLC2981                    ATOM  2858                                                                              CA TRP 411                                                                               8.787                                                                              13.047                                                                             29.871                                                                             1.00                                                                              32.40            1DLC2982                    ATOM  2859                                                                              C  TRP 411                                                                               7.681                                                                              13.644                                                                             28.982                                                                             1.00                                                                              36.76            1DLC2983                    ATOM  2860                                                                              O  TRP 411                                                                               7.783                                                                              14.797                                                                             28.558                                                                             1.00                                                                              37.48            1DLC2984                    ATOM  2861                                                                              CB TRP 411                                                                               8.374                                                                              13.087                                                                             31.341                                                                             1.00                                                                              30.13            1DLC2985                    ATOM  2862                                                                              CG TRP 411                                                                               9.146                                                                              12.153                                                                             32.224                                                                             1.00                                                                              31.99            1DLC2986                    ATOM  2863                                                                              CD1                                                                               TRP 411                                                                               10.500                                                                             12.010                                                                             32.283                                                                             1.00                                                                              32.36            1DLC2987                    ATOM  2864                                                                              CD2                                                                               TRP 411                                                                               8.609                                                                              11.291                                                                             33.237                                                                             1.00                                                                              33.30            1DLC2988                    ATOM  2865                                                                              NE1                                                                               TRP 411                                                                               10.841                                                                             11.127                                                                             33.274                                                                             1.00                                                                              31.66            1DLC2989                    ATOM  2866                                                                              CE2                                                                               TRP 411                                                                               9.700                                                                              10.671                                                                             33.878                                                                             1.00                                                                              34.52            1DLC2990                    ATOM  2867                                                                              CE3                                                                               TRP 411                                                                               7.310                                                                              10.988                                                                             33.670                                                                             1.00                                                                              33.48            1DLC2991                    ATOM  2868                                                                              CZ2                                                                               TRP 411                                                                               9.534                                                                              9.767                                                                              34.938                                                                             1.00                                                                              37.09            1DLC2992                    ATOM  2869                                                                              CZ3                                                                               TRP 411                                                                               7.146                                                                              10.089                                                                             34.725                                                                             1.00                                                                              33.78            1DLC2993                    ATOM  2870                                                                              CH2                                                                               TRP 411                                                                               8.253                                                                              9.492                                                                              35.345                                                                             1.00                                                                              33.59            1DLC2994                    ATOM  2871                                                                              N  PRO 412                                                                               6.574                                                                              12.900                                                                             28.755                                                                             1.00                                                                              41.54            1DLC2995                    ATOM  2872                                                                              CA PRO 412                                                                               5.451                                                                              13.348                                                                             27.917                                                                             1.00                                                                              41.87            1DLC2996                    ATOM  2873                                                                              C  PRO 412                                                                               4.993                                                                              14.776                                                                             28.158                                                                             1.00                                                                              43.64            1DLC2997                    ATOM  2874                                                                              O  PRO 412                                                                               4.725                                                                              15.517                                                                             27.218                                                                             1.00                                                                              46.92            1DLC2998                    ATOM  2875                                                                              CB PRO 412                                                                               4.349                                                                              12.361                                                                             28.277                                                                             1.00                                                                              39.76            1DLC2999                    ATOM  2876                                                                              CG PRO 412                                                                               5.098                                                                              11.130                                                                             28.537                                                                             1.00                                                                              42.46            1DLC3000                    ATOM  2877                                                                              CD PRO 412                                                                               6.231                                                                              11.620                                                                             29.399                                                                             1.00                                                                              41.84            1DLC3001                    ATOM  2878                                                                              N  SER 413                                                                               4.901                                                                              15.157                                                                             29.421                                                                             1.00                                                                              45.10            1DLC3002                    ATOM  2879                                                                              CA SER 413                                                                               4.460                                                                              16.501                                                                             29.764                                                                             1.00                                                                              49.60            1DLC3003                    ATOM  2880                                                                              C  SER 413                                                                               5.322                                                                              17.110                                                                             30.873                                                                             1.00                                                                              49.62            1DLC3004                    ATOM  2881                                                                              O  SER 413                                                                               4.843                                                                              17.900                                                                             31.695                                                                             1.00                                                                              51.51            1DLC3005                    ATOM  2882                                                                              CB SER 413                                                                               2.998                                                                              16.446                                                                             30.199                                                                             1.00                                                                              51.77            1DLC3006                    ATOM  2883                                                                              OG SER 413                                                                               2.797                                                                              15.328                                                                             31.045                                                                             1.00                                                                              57.37            1DLC3007                    ATOM  2884                                                                              N  ALA 414                                                                               6.607                                                                              16.764                                                                             30.865                                                                             1.00                                                                              45.33            1DLC3008                    ATOM  2885                                                                              CA ALA 414                                                                               7.534                                                                              17.257                                                                             31.871                                                                             1.00                                                                              38.96            1DLC3009                    ATOM  2886                                                                              C  ALA 414                                                                               8.979                                                                              16.981                                                                             31.485                                                                             1.00                                                                              36.86            1DLC3010                    ATOM  2887                                                                              O  ALA 414                                                                               9.275                                                                              16.041                                                                             30.750                                                                             1.00                                                                              36.90            1DLC3011                    ATOM  2888                                                                              CB ALA 414                                                                               7.227                                                                              16.613                                                                             33.222                                                                             1.00                                                                              36.07            1DLC3012                    ATOM  2889                                                                              N  VAL 415                                                                               9.874                                                                              17.834                                                                             31.959                                                                             1.00                                                                              31.55            1DLC3013                    ATOM  2890                                                                              CA VAL 415                                                                               11.294                                                                             17.667                                                                             31.713                                                                             1.00                                                                              28.69            1DLC3014                    ATOM  2891                                                                              C  VAL 415                                                                               11.957                                                                             17.736                                                                             33.083                                                                             1.00                                                                              27.90            1DLC3015                    ATOM  2892                                                                              O  VAL 415                                                                               11.636                                                                             18.604                                                                             33.895                                                                             1.00                                                                              28.78            1DLC3016                    ATOM  2893                                                                              CB VAL 415                                                                               11.850                                                                             18.764                                                                             30.770                                                                             1.00                                                                              26.51            1DLC3017                    ATOM  2894                                                                              CG1                                                                               VAL 415                                                                               13.373                                                                             18.695                                                                             30.699                                                                             1.00                                                                              27.88            1DLC3018                    ATOM  2895                                                                              CG2                                                                               VAL 415                                                                               11.272                                                                             18.594                                                                             29.379                                                                             1.00                                                                              24.80            1DLC3019                    ATOM  2896                                                                              N  TYR 416                                                                               12.806                                                                             16.760                                                                             33.372                                                                             1.00                                                                              25.67            1DLC3020                    ATOM  2897                                                                              CA TYR 416                                                                               13.504                                                                             16.713                                                                             34.648                                                                             1.00                                                                              26.02            1DLC3021                    ATOM  2898                                                                              C  TYR 416                                                                               14.992                                                                             16.821                                                                             34.407                                                                             1.00                                                                              26.24            1DLC3022                    ATOM  2899                                                                              O  TYR 416                                                                               15.537                                                                             16.120                                                                             33.560                                                                             1.00                                                                              28.40            1DLC3023                    ATOM  2900                                                                              CB TYR 416                                                                               13.209                                                                             15.399                                                                             35.366                                                                             1.00                                                                              26.73            1DLC3024                    ATOM  2901                                                                              CG TYR 416                                                                               11.746                                                                             15.180                                                                             35.657                                                                             1.00                                                                              29.24            1DLC3025                    ATOM  2902                                                                              CD1                                                                               TYR 416                                                                               10.910                                                                             14.571                                                                             34.720                                                                             1.00                                                                              30.70            1DLC3026                    ATOM  2903                                                                              CD2                                                                               TYR 416                                                                               11.194                                                                             15.583                                                                             36.869                                                                             1.00                                                                              28.65            1DLC3027                    ATOM  2904                                                                              CE1                                                                               TYR 416                                                                               9.567                                                                              14.373                                                                             34.985                                                                             1.00                                                                              30.31            1DLC3028                    ATOM  2905                                                                              CE2                                                                               TYR 416                                                                               9.857                                                                              15.387                                                                             37.144                                                                             1.00                                                                              31.22            1DLC3029                    ATOM  2906                                                                              CZ TYR 416                                                                               9.049                                                                              14.784                                                                             36.200                                                                             1.00                                                                              32.49            1DLC3030                    ATOM  2907                                                                              OH TYR 416                                                                               7.716                                                                              14.603                                                                             36.473                                                                             1.00                                                                              38.69            1DLC3031                    ATOM  2908                                                                              N  SER 417                                                                               15.650                                                                             17.706                                                                             35.138                                                                             1.00                                                                              27.76            1DLC3032                    ATOM  2909                                                                              CA SER 417                                                                               17.090                                                                             17.883                                                                             34.986                                                                             1.00                                                                              28.62            1DLC3033                    ATOM  2910                                                                              C  SER 417                                                                               17.796                                                                             18.114                                                                             36.319                                                                             1.00                                                                              28.34            1DLC3034                    ATOM  2911                                                                              O  SER 417                                                                               17.236                                                                             18.706                                                                             37.242                                                                             1.00                                                                              27.52            1DLC3035                    ATOM  2912                                                                              CB SER 417                                                                               17.403                                                                             19.015                                                                             34.003                                                                             1.00                                                                              26.82            1DLC3036                    ATOM  2913                                                                              OG SER 417                                                                               16.714                                                                             20.196                                                                             34.351                                                                             1.00                                                                              31.53            1DLC3037                    ATOM  2914                                                                              N  GLY 418                                                                               19.016                                                                             17.602                                                                             36.430                                                                             1.00                                                                              28.56            1DLC3038                    ATOM  2915                                                                              CA GLY 418                                                                               19.766                                                                             17.766                                                                             37.660                                                                             1.00                                                                              27.48            1DLC3039                    ATOM  2916                                                                              C  GLY 418                                                                               21.269                                                                             17.710                                                                             37.478                                                                             1.00                                                                              27.67            1DLC3040                    ATOM  2917                                                                              O  GLY 418                                                                               21.769                                                                             17.358                                                                             36.397                                                                             1.00                                                                              26.87            1DLC3041                    ATOM  2918                                                                              N  VAL 419                                                                               21.984                                                                             18.098                                                                             38.532                                                                             1.00                                                                              27.26            1DLC3042                    ATOM  2919                                                                              CA VAL 419                                                                               23.446                                                                             18.087                                                                             38.551                                                                             1.00                                                                              23.88            1DLC3043                    ATOM  2920                                                                              C  VAL 419                                                                               23.883                                                                             16.673                                                                             38.946                                                                             1.00                                                                              24.66            1DLC3044                    ATOM  2921                                                                              O  VAL 419                                                                               23.612                                                                             16.192                                                                             40.047                                                                             1.00                                                                              23.69            1DLC3045                    ATOM  2922                                                                              CB VAL 419                                                                               23.992                                                                             19.146                                                                             39.531                                                                             1.00                                                                              22.05            1DLC3046                    ATOM  2923                                                                              CG1                                                                               VAL 419                                                                               25.513                                                                             19.176                                                                             39.498                                                                             1.00                                                                              20.25            1DLC3047                    ATOM  2924                                                                              CG2                                                                               VAL 419                                                                               23.424                                                                             20.511                                                                             39.171                                                                             1.00                                                                              19.09            1DLC3048                    ATOM  2925                                                                              N  THR 420                                                                               24.552                                                                             16.006                                                                             38.022                                                                             1.00                                                                              24.57            1DLC3049                    ATOM  2926                                                                              CA THR 420                                                                               24.965                                                                             14.628                                                                             38.227                                                                             1.00                                                                              26.41            1DLC3050                    ATOM  2927                                                                              C  THR 420                                                                               26.407                                                                             14.410                                                                             38.671                                                                             1.00                                                                              29.16            1DLC3051                    ATOM  2928                                                                              O  THR 420                                                                               26.720                                                                             13.410                                                                             39.323                                                                             1.00                                                                              30.90            1DLC3052                    ATOM  2929                                                                              CB THR 420                                                                               24.781                                                                             13.874                                                                             36.938                                                                             1.00                                                                              26.62            1DLC3053                    ATOM  2930                                                                              OG1                                                                               THR 420                                                                               25.586                                                                             14.506                                                                             35.944                                                                             1.00                                                                              28.39            1DLC3054                    ATOM  2931                                                                              CG2                                                                               THR 420                                                                               23.329                                                                             13.938                                                                             36.484                                                                             1.00                                                                              27.96            1DLC3055                    ATOM  2932                                                                              N  LYS 421                                                                               27.292                                                                             15.325                                                                             38.295                                                                             1.00                                                                              31.11            1DLC3056                    ATOM  2933                                                                              CA LYS 421                                                                               28.704                                                                             15.194                                                                             38.646                                                                             1.00                                                                              30.22            1DLC3057                    ATOM  2934                                                                              C  LYS 421                                                                               29.363                                                                             16.550                                                                             38.868                                                                             1.00                                                                              28.76            1DLC3058                    ATOM  2935                                                                              O  LYS 421                                                                               29.099                                                                             17.506                                                                             38.138                                                                             1.00                                                                              26.51            1DLC3059                    ATOM  2936                                                                              CB LYS 421                                                                               29.433                                                                             14.443                                                                             37.526                                                                             1.00                                                                              29.98            1DLC3060                    ATOM  2937                                                                              CG LYS 421                                                                               30.858                                                                             14.012                                                                             37.820                                                                             1.00                                                                              29.15            1DLC3061                    ATOM  2938                                                                              CD LYS 421                                                                               31.539                                                                             13.708                                                                             36.499                                                                             1.00                                                                              33.33            1DLC3062                    ATOM  2939                                                                              CE LYS 421                                                                               33.002                                                                             13.320                                                                             36.640                                                                             1.00                                                                              36.06            1DLC3063                    ATOM  2940                                                                              NZ LYS 421                                                                               33.195                                                                             11.871                                                                             36.934                                                                             1.00                                                                              44.02            1DLC3064                    ATOM  2941                                                                              N  VAL 422                                                                               30.191                                                                             16.637                                                                             39.904                                                                             1.00                                                                              28.39            1DLC3065                    ATOM  2942                                                                              CA VAL 422                                                                               30.912                                                                             17.872                                                                             40.208                                                                             1.00                                                                              28.83            1DLC3066                    ATOM  2943                                                                              C  VAL 422                                                                               32.374                                                                             17.589                                                                             40.571                                                                             1.00                                                                              28.74            1DLC3067                    ATOM  2944                                                                              O  VAL 422                                                                               32.679                                                                             16.920                                                                             41.562                                                                             1.00                                                                              24.14            1DLC3068                    ATOM  2945                                                                              CB VAL 422                                                                               30.269                                                                             18.688                                                                             41.364                                                                             1.00                                                                              28.45            1DLC3069                    ATOM  2946                                                                              CG1                                                                               VAL 422                                                                               30.903                                                                             20.084                                                                             41.428                                                                             1.00                                                                              26.59            1DLC3070                    ATOM  2947                                                                              CG2                                                                               VAL 422                                                                               28.760                                                                             18.792                                                                             41.187                                                                             1.00                                                                              26.33            1DLC3071                    ATOM  2948                                                                              N  GLU 423                                                                               33.277                                                                             18.111                                                                             39.756                                                                             1.00                                                                              30.40            1DLC3072                    ATOM  2949                                                                              CA GLU 423                                                                               34.697                                                                             17.934                                                                             39.988                                                                             1.00                                                                              32.36            1DLC3073                    ATOM  2950                                                                              C  GLU 423                                                                               35.337                                                                             19.193                                                                             40.577                                                                             1.00                                                                              30.72            1DLC3074                    ATOM  2951                                                                              O  GLU 423                                                                               35.353                                                                             20.255                                                                             39.952                                                                             1.00                                                                              29.33            1DLC3075                    ATOM  2952                                                                              CB GLU 423                                                                               35.385                                                                             17.560                                                                             38.684                                                                             1.00                                                                              35.60            1DLC3076                    ATOM  2953                                                                              CG GLU 423                                                                               36.857                                                                             17.283                                                                             38.819                                                                             1.00                                                                              46.42            1DLC3077                    ATOM  2954                                                                              CD GLU 423                                                                               37.401                                                                             16.588                                                                             37.596                                                                             1.00                                                                              54.46            1DLC3078                    ATOM  2955                                                                              OE1                                                                               GLU 423                                                                               37.241                                                                             15.348                                                                             37.502                                                                             1.00                                                                              59.71            1DLC3079                    ATOM  2956                                                                              OE2                                                                               GLU 423                                                                               37.964                                                                             17.283                                                                             36.720                                                                             1.00                                                                              58.05            1DLC3080                    ATOM  2957                                                                              N  PHE 424                                                                               35.833                                                                             19.066                                                                             41.797                                                                             1.00                                                                              28.13            1DLC3081                    ATOM  2958                                                                              CA PHE 424                                                                               36.491                                                                             20.167                                                                             42.486                                                                             1.00                                                                              29.49            1DLC3082                    ATOM  2959                                                                              C  PHE 424                                                                               38.029                                                                             20.130                                                                             42.355                                                                             1.00                                                                              30.85            1DLC3083                    ATOM  2960                                                                              O  PHE 424                                                                               38.672                                                                             19.105                                                                             42.628                                                                             1.00                                                                              30.79            1DLC3084                    ATOM  2961                                                                              CB PHE 424                                                                               36.134                                                                             20.139                                                                             43.975                                                                             1.00                                                                              29.46            1DLC3085                    ATOM  2962                                                                              CG PHE 424                                                                               34.662                                                                             20.205                                                                             44.253                                                                             1.00                                                                              30.25            1DLC3086                    ATOM  2963                                                                              CD1                                                                               PHE 424                                                                               34.019                                                                             21.434                                                                             44.378                                                                             1.00                                                                              29.50            1DLC3087                    ATOM  2964                                                                              CD2                                                                               PHE 424                                                                               33.923                                                                             19.043                                                                             44.422                                                                             1.00                                                                              29.43            1DLC3088                    ATOM  2965                                                                              CE1                                                                               PHE 424                                                                               32.668                                                                             21.504                                                                             44.670                                                                             1.00                                                                              27.70            1DLC3089                    ATOM  2966                                                                              CE2                                                                               PHE 424                                                                               32.572                                                                             19.100                                                                             44.714                                                                             1.00                                                                              29.35            1DLC3090                    ATOM  2967                                                                              CZ PHE 424                                                                               31.942                                                                             20.336                                                                             44.840                                                                             1.00                                                                              30.09            1DLC3091                    ATOM  2968                                                                              N  SER 425                                                                               38.613                                                                             21.249                                                                             41.937                                                                             1.00                                                                              29.43            1DLC3092                    ATOM  2969                                                                              CA SER 425                                                                               40.065                                                                             21.361                                                                             41.830                                                                             1.00                                                                              25.64            1DLC3093                    ATOM  2970                                                                              C  SER 425                                                                               40.569                                                                             22.074                                                                             43.080                                                                             1.00                                                                              27.43            1DLC3094                    ATOM  2971                                                                              O  SER 425                                                                               40.136                                                                             23.184                                                                             43.390                                                                             1.00                                                                              27.70            1DLC3095                    ATOM  2972                                                                              CB SER 425                                                                               40.469                                                                             22.167                                                                             40.603                                                                             1.00                                                                              24.73            1DLC3096                    ATOM  2973                                                                              OG SER 425                                                                               40.202                                                                             21.458                                                                             39.410                                                                             1.00                                                                              27.45            1DLC3097                    ATOM  2974                                                                              N  GLN 426                                                                               41.459                                                                             21.428                                                                             43.815                                                                             1.00                                                                              29.40            1DLC3098                    ATOM  2975                                                                              CA GLN 426                                                                               42.010                                                                             22.018                                                                             45.028                                                                             1.00                                                                              34.28            1DLC3099                    ATOM  2976                                                                              C  GLN 426                                                                               43.541                                                                             22.162                                                                             45.029                                                                             1.00                                                                              37.43            1DLC3100                    ATOM  2977                                                                              O  GLN 426                                                                               44.257                                                                             21.428                                                                             44.344                                                                             1.00                                                                              38.20            1DLC3101                    ATOM  2978                                                                              CB GLN 426                                                                               41.548                                                                             21.225                                                                             46.251                                                                             1.00                                                                              32.26            1DLC3102                    ATOM  2979                                                                              CG GLN 426                                                                               41.830                                                                             19.736                                                                             46.179                                                                             1.00                                                                              33.97            1DLC3103                    ATOM  2980                                                                              CD GLN 426                                                                               41.196                                                                             18.983                                                                             47.329                                                                             1.00                                                                              37.54            1DLC3104                    ATOM  2981                                                                              OE1                                                                               GLN 426                                                                               40.063                                                                             19.258                                                                             47.714                                                                             1.00                                                                              39.93            1DLC3105                    ATOM  2982                                                                              NE2                                                                               GLN 426                                                                               41.919                                                                             18.028                                                                             47.884                                                                             1.00                                                                              37.39            1DLC3106                    ATOM  2983                                                                              N  TYR 427                                                                               44.026                                                                             23.163                                                                             45.754                                                                             1.00                                                                              40.45            1DLC3107                    ATOM  2984                                                                              CA TYR 427                                                                               45.455                                                                             23.402                                                                             45.872                                                                             1.00                                                                              41.55            1DLC3108                    ATOM  2985                                                                              C  TYR 427                                                                               45.819                                                                             23.459                                                                             47.351                                                                             1.00                                                                              42.39            1DLC3109                    ATOM  2986                                                                              O  TYR 427                                                                               45.118                                                                             24.072                                                                             48.149                                                                             1.00                                                                              40.82            1DLC3110                    ATOM  2987                                                                              CB TYR 427                                                                               45.846                                                                             24.713                                                                             45.186                                                                             1.00                                                                              44.27            1DLC3111                    ATOM  2988                                                                              CG TYR 427                                                                               47.328                                                                             25.006                                                                             45.252                                                                             1.00                                                                              49.58            1DLC3112                    ATOM  2989                                                                              CD1                                                                               TYR 427                                                                               48.219                                                                             24.383                                                                             44.377                                                                             1.00                                                                              51.96            1DLC3113                    ATOM  2990                                                                              CD2                                                                               TYR 427                                                                               47.848                                                                             25.883                                                                             46.209                                                                             1.00                                                                              49.78            1DLC3114                    ATOM  2991                                                                              CE1                                                                               TYR 427                                                                               49.589                                                                             24.622                                                                             44.448                                                                             1.00                                                                              52.52            1DLC3115                    ATOM  2992                                                                              CE2                                                                               TYR 427                                                                               49.218                                                                             26.128                                                                             46.292                                                                             1.00                                                                              52.70            1DLC3116                    ATOM  2993                                                                              CZ TYR 427                                                                               50.083                                                                             25.493                                                                             45.408                                                                             1.00                                                                              53.61            1DLC3117                    ATOM  2994                                                                              OH TYR 427                                                                               51.440                                                                             25.726                                                                             45.482                                                                             1.00                                                                              54.14            1DLC3118                    ATOM  2995                                                                              N  ASN 428                                                                               46.883                                                                             22.761                                                                             47.721                                                                             1.00                                                                              47.81            1DLC3119                    ATOM  2996                                                                              CA ASN 428                                                                               47.350                                                                             22.743                                                                             49.104                                                                             1.00                                                                              51.08            1DLC3120                    ATOM  2997                                                                              C  ASN 428                                                                               48.569                                                                             23.666                                                                             49.205                                                                             1.00                                                                              54.49            1DLC3121                    ATOM  2998                                                                              O  ASN 428                                                                               49.669                                                                             23.296                                                                             48.790                                                                             1.00                                                                              55.38            1DLC3122                    ATOM  2999                                                                              CB ASN 428                                                                               47.724                                                                             21.313                                                                             49.504                                                                             1.00                                                                              49.62            1DLC3123                    ATOM  3000                                                                              CG ASN 428                                                                               48.045                                                                             21.180                                                                             50.977                                                                             1.00                                                                              49.60            1DLC3124                    ATOM  3001                                                                              OD1                                                                               ASN 428                                                                               48.565                                                                             22.103                                                                             51.600                                                                             1.00                                                                              50.02            1DLC3125                    ATOM  3002                                                                              ND2                                                                               ASN 428                                                                               47.762                                                                             20.021                                                                             51.536                                                                             1.00                                                                              51.27            1DLC3126                    ATOM  3003                                                                              N  ASP 429                                                                               48.365                                                                             24.871                                                                             49.732                                                                             1.00                                                                              57.69            1DLC3127                    ATOM  3004                                                                              CA ASP 429                                                                               49.447                                                                             25.851                                                                             49.868                                                                             1.00                                                                              61.09            1DLC3128                    ATOM  3005                                                                              C  ASP 429                                                                               50.553                                                                             25.433                                                                             50.846                                                                             1.00                                                                              61.35            1DLC3129                    ATOM  3006                                                                              O  ASP 429                                                                               51.663                                                                             25.955                                                                             50.798                                                                             1.00                                                                              60.38            1DLC3130                    ATOM  3007                                                                              CB ASP 429                                                                               48.884                                                                             27.234                                                                             50.231                                                                             1.00                                                                              63.50            1DLC3131                    ATOM  3008                                                                              CG ASP 429                                                                               48.083                                                                             27.225                                                                             51.521                                                                             1.00                                                                              69.23            1DLC3132                    ATOM  3009                                                                              OD1                                                                               ASP 429                                                                               47.071                                                                             26.486                                                                             51.596                                                                             1.00                                                                              74.87            1DLC3133                    ATOM  3010                                                                              OD2                                                                               ASP 429                                                                               48.462                                                                             27.960                                                                             52.463                                                                             1.00                                                                              69.36            1DLC3134                    ATOM  3011                                                                              N  GLN 430                                                                               50.246                                                                             24.488                                                                             51.729                                                                             1.00                                                                              63.12            1DLC3135                    ATOM  3012                                                                              CA GLN 430                                                                               51.227                                                                             23.987                                                                             52.688                                                                             1.00                                                                              64.06            1DLC3136                    ATOM  3013                                                                              C  GLN 430                                                                               52.185                                                                             23.064                                                                             51.938                                                                             1.00                                                                              60.99            1DLC3137                    ATOM  3014                                                                              O  GLN 430                                                                               53.368                                                                             23.353                                                                             51.802                                                                             1.00                                                                              62.46            1DLC3138                    ATOM  3015                                                                              CB GLN 430                                                                               50.543                                                                             23.202                                                                             53.817                                                                             1.00                                                                              68.60            1DLC3139                    ATOM  3016                                                                              CG GLN 430                                                                               49.735                                                                             24.035                                                                             54.821                                                                             1.00                                                                              77.24            1DLC3140                    ATOM  3017                                                                              CD GLN 430                                                                               48.372                                                                             24.495                                                                             54.295                                                                             1.00                                                                              83.08            1DLC3141                    ATOM  3018                                                                              OE1                                                                               GLN 430                                                                               48.121                                                                             25.694                                                                             54.164                                                                             1.00                                                                              86.17            1DLC3142                    ATOM  3019                                                                              NE2                                                                               GLN 430                                                                               47.483                                                                             23.546                                                                             54.020                                                                             1.00                                                                              82.81            1DLC3143                    ATOM  3020                                                                              N  THR 431                                                                               51.643                                                                             21.973                                                                             51.409                                                                             1.00                                                                              57.70            1DLC3144                    ATOM  3021                                                                              CA THR 431                                                                               52.425                                                                             20.992                                                                             50.658                                                                             1.00                                                                              54.67            1DLC3145                    ATOM  3022                                                                              C  THR 431                                                                               52.553                                                                             21.360                                                                             49.179                                                                             1.00                                                                              53.42            1DLC3146                    ATOM  3023                                                                              O  THR 431                                                                               52.775                                                                             20.505                                                                             48.334                                                                             1.00                                                                              52.29            1DLC3147                    ATOM  3024                                                                              CB THR 431                                                                               51.786                                                                             19.594                                                                             50.760                                                                             1.00                                                                              54.43            1DLC3148                    ATOM  3025                                                                              OG1                                                                               THR 431                                                                               50.488                                                                             19.617                                                                             50.155                                                                             1.00                                                                              55.57            1DLC3149                    ATOM  3026                                                                              CG2                                                                               THR 431                                                                               51.627                                                                             19.188                                                                             52.223                                                                             1.00                                                                              54.20            1DLC3150                    ATOM  3027                                                                              N  ASP 432                                                                               52.399                                                                             22.643                                                                             48.883                                                                             1.00                                                                              55.66            1DLC3151                    ATOM  3028                                                                              CA ASP 432                                                                               52.476                                                                             23.176                                                                             47.526                                                                             1.00                                                                              59.05            1DLC3152                    ATOM  3029                                                                              C  ASP 432                                                                               52.136                                                                             22.273                                                                             46.343                                                                             1.00                                                                              59.61            1DLC3153                    ATOM  3030                                                                              O  ASP 432                                                                               52.945                                                                             22.109                                                                             45.428                                                                             1.00                                                                              61.57            1DLC3154                    ATOM  3031                                                                              CB ASP 432                                                                               53.816                                                                             23.875                                                                             47.288                                                                             1.00                                                                              63.68            1DLC3155                    ATOM  3032                                                                              CG ASP 432                                                                               53.877                                                                             25.252                                                                             47.934                                                                             1.00                                                                              69.48            1DLC3156                    ATOM  3033                                                                              OD1                                                                               ASP 432                                                                               53.439                                                                             26.238                                                                             47.293                                                                             1.00                                                                              70.82            1DLC3157                    ATOM  3034                                                                              OD2                                                                               ASP 432                                                                               54.360                                                                             25.347                                                                             49.086                                                                             1.00                                                                              71.66            1DLC3158                    ATOM  3035                                                                              N  GLU 433                                                                               50.928                                                                             21.711                                                                             46.346                                                                             1.00                                                                              59.44            1DLC3159                    ATOM  3036                                                                              CA GLU 433                                                                               50.480                                                                             20.871                                                                             45.233                                                                             1.00                                                                              57.29            1DLC3160                    ATOM  3037                                                                              C  GLU 433                                                                               48.957                                                                             20.787                                                                             45.047                                                                             1.00                                                                              52.84            1DLC3161                    ATOM  3038                                                                              O  GLU 433                                                                               48.178                                                                             20.915                                                                             45.994                                                                             1.00                                                                              46.51            1DLC3162                    ATOM  3039                                                                              CB GLU 433                                                                               51.137                                                                             19.476                                                                             45.260                                                                             1.00                                                                              63.46            1DLC3163                    ATOM  3040                                                                              CG GLU 433                                                                               50.290                                                                             18.331                                                                             45.795                                                                             1.00                                                                              69.79            1DLC3164                    ATOM  3041                                                                              CD GLU 433                                                                               50.272                                                                             18.275                                                                             47.305                                                                             1.00                                                                              74.20            1DLC3165                    ATOM  3042                                                                              OE1                                                                               GLU 433                                                                               51.179                                                                             17.634                                                                             47.887                                                                             1.00                                                                              75.74            1DLC3166                    ATOM  3043                                                                              OE2                                                                               GLU 433                                                                               49.349                                                                             18.868                                                                             47.907                                                                             1.00                                                                              78.38            1DLC3167                    ATOM  3044                                                                              N  ALA 434                                                                               48.553                                                                             20.634                                                                             43.792                                                                             1.00                                                                              51.12            1DLC3168                    ATOM  3045                                                                              CA ALA 434                                                                               47.146                                                                             20.552                                                                             43.419                                                                             1.00                                                                              50.02            1DLC3169                    ATOM  3046                                                                              C  ALA 434                                                                               46.636                                                                             19.113                                                                             43.301                                                                             1.00                                                                              48.51            1DLC3170                    ATOM  3047                                                                              O  ALA 434                                                                               47.418                                                                             18.168                                                                             43.249                                                                             1.00                                                                              51.46            1DLC3171                    ATOM  3048                                                                              CB ALA 434                                                                               46.913                                                                             21.302                                                                             42.107                                                                             1.00                                                                              49.76            1DLC3172                    ATOM  3049                                                                              N  SER 435                                                                               45.316                                                                             18.969                                                                             43.250                                                                             1.00                                                                              44.96            1DLC3173                    ATOM  3050                                                                              CA SER 435                                                                               44.650                                                                             17.674                                                                             43.139                                                                             1.00                                                                              38.99            1DLC3174                    ATOM  3051                                                                              C  SER 435                                                                               43.159                                                                             17.914                                                                             42.940                                                                             1.00                                                                              39.56            1DLC3175                    ATOM  3052                                                                              O  SER 435                                                                               42.693                                                                             19.048                                                                             42.999                                                                             1.00                                                                              38.70            1DLC3176                    ATOM  3053                                                                              CB SER 435                                                                               44.845                                                                             16.857                                                                             44.415                                                                             1.00                                                                              35.36            1DLC3177                    ATOM  3054                                                                              OG SER 435                                                                               44.241                                                                             17.492                                                                             45.528                                                                             1.00                                                                              32.98            1DLC3178                    ATOM  3055                                                                              N  THR 436                                                                               42.407                                                                             16.847                                                                             42.705                                                                             1.00                                                                              38.68            1DLC3179                    ATOM  3056                                                                              CA THR 436                                                                               40.967                                                                             16.979                                                                             42.526                                                                             1.00                                                                              36.86            1DLC3180                    ATOM  3057                                                                              C  THR 436                                                                               40.171                                                                             16.007                                                                             43.392                                                                             1.00                                                                              36.34            1DLC3181                    ATOM  3058                                                                              O  THR 436                                                                               40.679                                                                             14.970                                                                             43.823                                                                             1.00                                                                              37.73            1DLC3182                    ATOM  3059                                                                              CB THR 436                                                                               40.540                                                                             16.757                                                                             41.065                                                                             1.00                                                                              35.68            1DLC3183                    ATOM  3060                                                                              OG1                                                                               THR 436                                                                               40.788                                                                             15.397                                                                             40.699                                                                             1.00                                                                              41.63            1DLC3184                    ATOM  3061                                                                              CG2                                                                               THR 436                                                                               41.313                                                                             17.674                                                                             40.130                                                                             1.00                                                                              37.09            1DLC3185                    ATOM  3062                                                                              N  GLN 437                                                                               38.947                                                                             16.407                                                                             43.713                                                                             1.00                                                                              35.55            1DLC3186                    ATOM  3063                                                                              CA GLN 437                                                                               38.009                                                                             15.597                                                                             44.485                                                                             1.00                                                                              33.02            1DLC3187                    ATOM  3064                                                                              C  GLN 437                                                                               36.709                                                                             15.729                                                                             43.723                                                                             1.00                                                                              34.09            1DLC3188                    ATOM  3065                                                                              O  GLN 437                                                                               36.391                                                                             16.809                                                                             43.227                                                                             1.00                                                                              34.18            1DLC3189                    ATOM  3066                                                                              CB GLN 437                                                                               37.813                                                                             16.140                                                                             45.894                                                                             1.00                                                                              30.43            1DLC3190                    ATOM  3067                                                                              CG GLN 437                                                                               38.812                                                                             15.635                                                                             46.887                                                                             1.00                                                                              30.16            1DLC3191                    ATOM  3068                                                                              CD GLN 437                                                                               38.380                                                                             15.896                                                                             48.305                                                                             1.00                                                                              32.30            1DLC3192                    ATOM  3069                                                                              OE1                                                                               GLN 437                                                                               37.962                                                                             14.984                                                                             49.015                                                                             1.00                                                                              36.80            1DLC3193                    ATOM  3070                                                                              NE2                                                                               GLN 437                                                                               38.458                                                                             17.144                                                                             48.726                                                                             1.00                                                                              34.86            1DLC3194                    ATOM  3071                                                                              N  THR 438                                                                               35.966                                                                             14.644                                                                             43.575                                                                             1.00                                                                              34.88            1DLC3195                    ATOM  3072                                                                              CA THR 438                                                                               34.725                                                                             14.759                                                                             42.828                                                                             1.00                                                                              35.70            1DLC3196                    ATOM  3073                                                                              C  THR 438                                                                               33.533                                                                             14.042                                                                             43.417                                                                             1.00                                                                              34.07            1DLC3197                    ATOM  3074                                                                              O  THR 438                                                                               33.663                                                                             13.090                                                                             44.177                                                                             1.00                                                                              35.71            1DLC3198                    ATOM  3075                                                                              CB THR 438                                                                               34.857                                                                             14.280                                                                             41.346                                                                             1.00                                                                              37.66            1DLC3199                    ATOM  3076                                                                              OG1                                                                               THR 438                                                                               34.466                                                                             12.905                                                                             41.251                                                                             1.00                                                                              37.09            1DLC3200                    ATOM  3077                                                                              CG2                                                                               THR 438                                                                               36.286                                                                             14.453                                                                             40.812                                                                             1.00                                                                              32.87            1DLC3201                    ATOM  3078                                                                              N  TYR 439                                                                               32.366                                                                             14.560                                                                             43.074                                                                             1.00                                                                              34.88            1DLC3202                    ATOM  3079                                                                              CA TYR 439                                                                               31.100                                                                             13.988                                                                             43.473                                                                             1.00                                                                              32.18            1DLC3203                    ATOM  3080                                                                              C  TYR 439                                                                               30.575                                                                             13.313                                                                             42.197                                                                             1.00                                                                              32.47            1DLC3204                    ATOM  3081                                                                              O  TYR 439                                                                               30.636                                                                             13.888                                                                             41.102                                                                             1.00                                                                              30.88            1DLC3205                    ATOM  3082                                                                              CB TYR 439                                                                               30.141                                                                             15.089                                                                             43.936                                                                             1.00                                                                              29.14            1DLC3206                    ATOM  3083                                                                              CG TYR 439                                                                               28.691                                                                             14.683                                                                             43.824                                                                             1.00                                                                              30.66            1DLC3207                    ATOM  3084                                                                              CD1                                                                               TYR 439                                                                               28.126                                                                             13.796                                                                             44.738                                                                             1.00                                                                              28.98            1DLC3208                    ATOM  3085                                                                              CD2                                                                               TYR 439                                                                               27.902                                                                             15.117                                                                             42.751                                                                             1.00                                                                              27.98            1DLC3209                    ATOM  3086                                                                              CE1                                                                               TYR 439                                                                               26.825                                                                             13.344                                                                             44.588                                                                             1.00                                                                              29.00            1DLC3210                    ATOM  3087                                                                              CE2                                                                               TYR 439                                                                               26.598                                                                             14.667                                                                             42.595                                                                             1.00                                                                              26.79            1DLC3211                    ATOM  3088                                                                              CZ TYR 439                                                                               26.072                                                                             13.778                                                                             43.518                                                                             1.00                                                                              25.85            1DLC3212                    ATOM  3089                                                                              OH TYR 439                                                                               24.798                                                                             13.305                                                                             43.369                                                                             1.00                                                                              25.37            1DLC3213                    ATOM  3090                                                                              N  ASP 440                                                                               30.098                                                                             12.082                                                                             42.323                                                                             1.00                                                                              33.95            1DLC3214                    ATOM  3091                                                                              CA ASP 440                                                                               29.568                                                                             11.366                                                                             41.162                                                                             1.00                                                                              36.24            1DLC3215                    ATOM  3092                                                                              C  ASP 440                                                                               28.231                                                                             10.735                                                                             41.551                                                                             1.00                                                                              37.15            1DLC3216                    ATOM  3093                                                                              O  ASP 440                                                                               28.152                                                                             10.014                                                                             42.547                                                                             1.00                                                                              37.73            1DLC3217                    ATOM  3094                                                                              CB ASP 440                                                                               30.560                                                                             10.285                                                                             40.711                                                                             1.00                                                                              37.85            1DLC3218                    ATOM  3095                                                                              CG ASP 440                                                                               30.332                                                                             9.831                                                                              39.277                                                                             1.00                                                                              40.56            1DLC3219                    ATOM  3096                                                                              OD1                                                                               ASP 440                                                                               29.253                                                                             9.284                                                                              38.975                                                                             1.00                                                                              45.14            1DLC3220                    ATOM  3097                                                                              OD2                                                                               ASP 440                                                                               31.246                                                                             10.006                                                                             38.442                                                                             1.00                                                                              44.83            1DLC3221                    ATOM  3098                                                                              N  SER 441                                                                               27.177                                                                             11.035                                                                             40.794                                                                             1.00                                                                              36.81            1DLC3222                    ATOM  3099                                                                              CA SER 441                                                                               25.851                                                                             10.483                                                                             41.087                                                                             1.00                                                                              36.80            1DLC3223                    ATOM  3100                                                                              C  SER 441                                                                               25.825                                                                             8.972                                                                              40.882                                                                             1.00                                                                              39.60            1DLC3224                    ATOM  3101                                                                              O  SER 441                                                                               25.000                                                                             8.271                                                                              41.467                                                                             1.00                                                                              40.38            1DLC3225                    ATOM  3102                                                                              CB SER 441                                                                               24.781                                                                             11.133                                                                             40.212                                                                             1.00                                                                              33.16            1DLC3226                    ATOM  3103                                                                              OG SER 441                                                                               24.910                                                                             10.741                                                                             38.857                                                                             1.00                                                                              34.23            1DLC3227                    ATOM  3104                                                                              N  LYS 442                                                                               26.738                                                                             8.495                                                                              40.039                                                                             1.00                                                                              41.35            1DLC3228                    ATOM  3105                                                                              CA LYS 442                                                                               26.901                                                                             7.078                                                                              39.701                                                                             1.00                                                                              45.48            1DLC3229                    ATOM  3106                                                                              C  LYS 442                                                                               25.977                                                                             6.509                                                                              38.618                                                                             1.00                                                                              46.07            1DLC3230                    ATOM  3107                                                                              O  LYS 442                                                                               26.260                                                                             5.446                                                                              38.055                                                                             1.00                                                                              49.36            1DLC3231                    ATOM  3108                                                                              CB LYS 442                                                                               26.905                                                                             6.192                                                                              40.953                                                                             1.00                                                                              49.45            1DLC3232                    ATOM  3109                                                                              CG LYS 442                                                                               28.279                                                                             5.606                                                                              41.309                                                                             1.00                                                                              56.04            1DLC3233                    ATOM  3110                                                                              CD LYS 442                                                                               28.626                                                                             4.379                                                                              40.446                                                                             1.00                                                                              58.91            1DLC3234                    ATOM  3111                                                                              CE LYS 442                                                                               29.111                                                                             4.762                                                                              39.050                                                                             1.00                                                                              60.19            1DLC3235                    ATOM  3112                                                                              NZ LYS 442                                                                               28.866                                                                             3.683                                                                              38.044                                                                             1.00                                                                              60.75            1DLC3236                    ATOM  3113                                                                              N  ARG 443                                                                               24.885                                                                             7.201                                                                              38.310                                                                             1.00                                                                              43.51                                                                              1            1DLC3237                    ATOM  3114                                                                              CA ARG 443                                                                               24.001                                                                             6.738                                                                              37.247                                                                             1.00                                                                              40.12                                                                              1            1DLC3238                    ATOM  3115                                                                              C  ARG 443                                                                               23.716                                                                             7.807                                                                              36.191                                                                             1.00                                                                              39.29                                                                              1            1DLC3239                    ATOM  3116                                                                              O  ARG 443                                                                               23.231                                                                             8.897                                                                              36.498                                                                             1.00                                                                              39.09                                                                              1            1DLC3240                    ATOM  3117                                                                              CB AARG                                                                               443                                                                               22.686                                                                             6.168                                                                              37.792                                                                             0.50                                                                              39.58                                                                              1            1DLC3241                    ATOM  3118                                                                              CB BARG                                                                               443                                                                               22.701                                                                             6.194                                                                              37.849                                                                             0.50                                                                              39.12                                                                              1            1DLC3242                    ATOM  3119                                                                              CG AARG                                                                               443                                                                               21.828                                                                             5.580                                                                              36.678                                                                             0.50                                                                              38.20                                                                              1            1DLC3243                    ATOM  3120                                                                              CG BARG                                                                               443                                                                               21.551                                                                             6.015                                                                              36.868                                                                             0.50                                                                              37.50                                                                              1            1DLC3244                    ATOM  3121                                                                              CD AARG                                                                               443                                                                               20.703                                                                             4.678                                                                              37.156                                                                             0.50                                                                              38.35                                                                              1            1DLC3245                    ATOM  3122                                                                              CD BARG                                                                               443                                                                               20.501                                                                             5.057                                                                              37.413                                                                             0.50                                                                              36.41                                                                              1            1DLC3246                    ATOM  3123                                                                              NE AARG                                                                               443                                                                               20.266                                                                             3.824                                                                              36.050                                                                             0.50                                                                              38.24                                                                              1            1DLC3247                    ATOM  3124                                                                              NE BARG                                                                               443                                                                               20.317                                                                             5.184                                                                              38.857                                                                             0.50                                                                              34.60                                                                              1            1DLC3248                    ATOM  3125                                                                              CZ AARG                                                                               443                                                                               19.076                                                                             3.238                                                                              35.951                                                                             0.50                                                                              37.74                                                                              1            1DLC3249                    ATOM  3126                                                                              CZ BARG                                                                               443                                                                               19.823                                                                             4.226                                                                              39.636                                                                             0.50                                                                              34.26                                                                              1            1DLC3250                    ATOM  3127                                                                              NH1                                                                               AARG                                                                               443                                                                               18.160                                                                             3.392                                                                              36.895                                                                             0.50                                                                              38.52                                                                              1            1DLC3251                    ATOM  3128                                                                              NH1                                                                               BARG                                                                               443                                                                               19.452                                                                             3.064                                                                              39.110                                                                             0.50                                                                              31.83                                                                              1            1DLC3252                    ATOM  3129                                                                              NH2                                                                               AARG                                                                               443                                                                               18.798                                                                             2.508                                                                              34.882                                                                             0.50                                                                              37.87                                                                              1            1DLC3253                    ATOM  3136                                                                              NH2                                                                               BARG                                                                               443                                                                               19.727                                                                             4.418                                                                              40.948                                                                             0.50                                                                              31.14                                                                              1            1DLC3254                    ATOM  3131                                                                              N  ASN 444                                                                               24.070                                                                             7.481                                                                              34.950                                                                             1.00                                                                              40.97            1DLC3255                    ATOM  3132                                                                              CA ASN 444                                                                               23.882                                                                             8.350                                                                              33.784                                                                             1.00                                                                              41.75            1DLC3256                    ATOM  3133                                                                              C  ASN 444                                                                               24.271                                                                             9.814                                                                              34.045                                                                             1.00                                                                              42.79            1DLC3257                    ATOM  3134                                                                              O  ASN 444                                                                               23.421                                                                             10.700                                                                             34.174                                                                             1.00                                                                              42.71            1DLC3258                    ATOM  3135                                                                              CB ASN 444                                                                               22.446                                                                             8.230                                                                              33.271                                                                             1.00                                                                              43.21            1DLC3259                    ATOM  3136                                                                              CG ASN 444                                                                               22.280                                                                             8.764                                                                              31.862                                                                             1.00                                                                              44.75            1DLC3260                    ATOM  3137                                                                              OD1                                                                               ASN 444                                                                               23.258                                                                             9.086                                                                              31.182                                                                             1.00                                                                              47.47            1DLC3261                    ATOM  3138                                                                              ND2                                                                               ASN 444                                                                               21.040                                                                             8.867                                                                              31.418                                                                             1.00                                                                              45.66            1DLC3262                    ATOM  3139                                                                              N  VAL 445                                                                               25.579                                                                             10.041                                                                             34.079                                                                             1.00                                                                              42.96            1DLC3263                    ATOM  3140                                                                              CA VAL 445                                                                               26.195                                                                             11.345                                                                             34.342                                                                             1.00                                                                              41.13            1DLC3264                    ATOM  3141                                                                              C  VAL 445                                                                               26.035                                                                             12.460                                                                             33.282                                                                             1.00                                                                              39.24            1DLC3265                    ATOM  3142                                                                              O  VAL 445                                                                               26.037                                                                             13.641                                                                             33.602                                                                             1.00                                                                              41.51            1DLC3266                    ATOM  3143                                                                              CB VAL 445                                                                               27.694                                                                             11.117                                                                             34.702                                                                             1.00                                                                              41.94            1DLC3267                    ATOM  3144                                                                              CG1                                                                               VAL 445                                                                               28.516                                                                             12.385                                                                             34.554                                                                             1.00                                                                              43.22            1DLC3268                    ATOM  3145                                                                              CG2                                                                               VAL 445                                                                               27.796                                                                             10.562                                                                             36.116                                                                             1.00                                                                              37.86            1DLC3269                    ATOM  3146                                                                              N  GLY 446                                                                               25.888                                                                             12.108                                                                             32.020                                                                             1.00                                                                              38.45            1DLC3270                    ATOM  3147                                                                              CA GLY 446                                                                               25.737                                                                             13.157                                                                             31.032                                                                             1.00                                                                              37.87            1DLC3271                    ATOM  3148                                                                              C  GLY 446                                                                               27.023                                                                             13.933                                                                             30.806                                                                             1.00                                                                              38.06            1DLC3272                    ATOM  3149                                                                              O  GLY 446                                                                               28.108                                                                             13.458                                                                             31.137                                                                             1.00                                                                              39.17            1DLC3273                    ATOM  3150                                                                              N  ALA 447                                                                               26.899                                                                             15.146                                                                             30.276                                                                             1.00                                                                              38.09            1DLC3274                    ATOM  3151                                                                              CA ALA 447                                                                               28.060                                                                             15.980                                                                             29.973                                                                             1.00                                                                              37.35            1DLC3275                    ATOM  3152                                                                              C  ALA 447                                                                               28.222                                                                             17.226                                                                             30.847                                                                             1.00                                                                              35.81            1DLC3276                    ATOM  3153                                                                              O  ALA 447                                                                               27.291                                                                             17.651                                                                             31.535                                                                             1.00                                                                              35.86            1DLC3277                    ATOM  3154                                                                              CB ALA 447                                                                               28.043                                                                             16.373                                                                             28.490                                                                             1.00                                                                              38.30            1DLC3278                    ATOM  3155                                                                              N  VAL 448                                                                               29.426                                                                             17.794                                                                             30.818                                                                             1.00                                                                              33.69            1DLC3279                    ATOM  3156                                                                              CA VAL 448                                                                               29.736                                                                             18.992                                                                             31.590                                                                             1.00                                                                              32.06            1DLC3280                    ATOM  3157                                                                              C  VAL 448                                                                               29.041                                                                             20.194                                                                             30.976                                                                             1.00                                                                              30.84            1DLC3281                    ATOM  3158                                                                              O  VAL 448                                                                               29.117                                                                             20.413                                                                             29.771                                                                             1.00                                                                              30.03            1DLC3282                    ATOM  3159                                                                              CB VAL 448                                                                               31.275                                                                             19.263                                                                             31.695                                                                             1.00                                                                              30.42            1DLC3283                    ATOM  3160                                                                              CG1                                                                               VAL 448                                                                               31.936                                                                             18.203                                                                             32.547                                                                             1.00                                                                              30.39            1DLC3284                    ATOM  3161                                                                              CG2                                                                               VAL 448                                                                               31.919                                                                             19.283                                                                             30.334                                                                             1.00                                                                              28.17            1DLC3285                    ATOM  3162                                                                              N  SER 449                                                                               28.324                                                                             20.942                                                                             31.805                                                                             1.00                                                                              29.95            1DLC3286                    ATOM  3163                                                                              CA SER 449                                                                               27.609                                                                             22.116                                                                             31.326                                                                             1.00                                                                              30.08            1DLC3287                    ATOM  3164                                                                              C  SER 449                                                                               27.940                                                                             23.393                                                                             32.100                                                                             1.00                                                                              29.27            1DLC3288                    ATOM  3165                                                                              O  SER 449                                                                               27.571                                                                             24.486                                                                             31.675                                                                             1.00                                                                              29.45            1DLC3289                    ATOM  3166                                                                              CB SER 449                                                                               26.093                                                                             21.875                                                                             31.386                                                                             1.00                                                                              31.17            1DLC3290                    ATOM  3167                                                                              OG SER 449                                                                               25.616                                                                             21.864                                                                             32.723                                                                             1.00                                                                              32.27            1DLC3291                    ATOM  3168                                                                              N  TRP 450                                                                               28.668                                                                             23.264                                                                             33.206                                                                             1.00                                                                              26.45            1DLC3292                    ATOM  3169                                                                              CA TRP 450                                                                               28.993                                                                             24.427                                                                             34.023                                                                             1.00                                                                              24.97            1DLC3293                    ATOM  3170                                                                              C  TRP 450                                                                               30.444                                                                             24.442                                                                             34.525                                                                             1.00                                                                              25.78            1DLC3294                    ATOM  3171                                                                              O  TRP 450                                                                               30.903                                                                             23.514                                                                             35.193                                                                             1.00                                                                              26.98            1DLC3295                    ATOM  3172                                                                              CB TRP 450                                                                               28.003                                                                             24.475                                                                             35.198                                                                             1.00                                                                              22.55            1DLC3296                    ATOM  3173                                                                              CG TRP 450                                                                               28.003                                                                             25.718                                                                             36.062                                                                             1.00                                                                              24.05            1DLC3297                    ATOM  3174                                                                              CD1                                                                               TRP 450                                                                               27.071                                                                             26.723                                                                             36.046                                                                             1.00                                                                              24.31            1DLC3298                    ATOM  3175                                                                              CD2                                                                               TRP 450                                                                               28.864                                                                             25.994                                                                             37.181                                                                             1.00                                                                              22.36            1DLC3299                    ATOM  3176                                                                              NE1                                                                               TRP 450                                                                               27.282                                                                             27.585                                                                             37.101                                                                             1.00                                                                              24.38            1DLC3300                    ATOM  3177                                                                              CE2                                                                               TRP 450                                                                               28.376                                                                             27.163                                                                             37.809                                                                             1.00                                                                              22.02            1DLC3301                    ATOM  3178                                                                              CE3                                                                               TRP 450                                                                               29.989                                                                             25.361                                                                             37.719                                                                             1.00                                                                              23.01            1DLC3302                    ATOM  3179                                                                              CZ2                                                                               TRP 450                                                                               28.970                                                                             27.705                                                                             38.946                                                                             1.00                                                                              23.92            1DLC3303                    ATOM  3180                                                                              CZ3                                                                               TRP 450                                                                               30.579                                                                             25.902                                                                             38.852                                                                             1.00                                                                              23.85            1DLC3304                    ATOM  3181                                                                              CH2                                                                               TRP 450                                                                               30.068                                                                             27.062                                                                             39.451                                                                             1.00                                                                              24.68            1DLC3305                    ATOM  3182                                                                              N  ASP 451                                                                               31.148                                                                             25.529                                                                             34.227                                                                             1.00                                                                              26.82            1DLC3306                    ATOM  3183                                                                              CA ASP 451                                                                               32.541                                                                             25.703                                                                             34.640                                                                             1.00                                                                              23.64            1DLC3307                    ATOM  3184                                                                              C  ASP 451                                                                               32.701                                                                             27.046                                                                             35.359                                                                             1.00                                                                              22.66            1DLC3308                    ATOM  3185                                                                              O  ASP 451                                                                               32.479                                                                             28.103                                                                             34.760                                                                             1.00                                                                              20.61            1DLC3309                    ATOM  3186                                                                              CB ASP 451                                                                               33.451                                                                             25.675                                                                             33.406                                                                             1.00                                                                              22.67            1DLC3310                    ATOM  3187                                                                              CG ASP 451                                                                               34.920                                                                             25.461                                                                             33.749                                                                             1.00                                                                              24.25            1DLC3311                    ATOM  3188                                                                              OD1                                                                               ASP 451                                                                               35.325                                                                             25.616                                                                             34.919                                                                             1.00                                                                              24.75            1DLC3312                    ATOM  3189                                                                              OD2                                                                               ASP 451                                                                               35.674                                                                             25.116                                                                             32.824                                                                             1.00                                                                              24.52            1DLC3313                    ATOM  3190                                                                              N  SER 452                                                                               33.106                                                                             27.001                                                                             36.629                                                                             1.00                                                                              20.91            1DLC3314                    ATOM  3191                                                                              CA SER 452                                                                               33.307                                                                             28.219                                                                             37.432                                                                             1.00                                                                              22.01            1DLC3315                    ATOM  3192                                                                              C  SER 452                                                                               34.262                                                                             29.231                                                                             36.786                                                                             1.00                                                                              23.43            1DLC3316                    ATOM  3193                                                                              O  SER 452                                                                               34.036                                                                             30.443                                                                             36.833                                                                             1.00                                                                              23.61            1DLC3317                    ATOM  3194                                                                              CB SER 452                                                                               33.799                                                                             27.868                                                                             38.840                                                                             1.00                                                                              20.07            1DLC3318                    ATOM  3195                                                                              OG SER 452                                                                               34.950                                                                             27.049                                                                             38.793                                                                             1.00                                                                              22.47            1DLC3319                    ATOM  3196                                                                              N  ILE 453                                                                               35.291                                                                             28.724                                                                             36.122                                                                             1.00                                                                              25.73            1DLC3320                    ATOM  3197                                                                              CA ILE 453                                                                               36.272                                                                             29.571                                                                             35.454                                                                             1.00                                                                              27.62            1DLC3321                    ATOM  3198                                                                              C  ILE 453                                                                               35.641                                                                             30.563                                                                             34.469                                                                             1.00                                                                              25.55            1DLC3322                    ATOM  3199                                                                              O  ILE 453                                                                               36.181                                                                             31.645                                                                             34.255                                                                             1.00                                                                              28.13            1DLC3323                    ATOM  3200                                                                              CB ILE 453                                                                               37.383                                                                             28.691                                                                             34.786                                                                             1.00                                                                              29.82            1DLC3324                    ATOM  3201                                                                              CG1                                                                               ILE 453                                                                               38.345                                                                             28.183                                                                             35.866                                                                             1.00                                                                              35.65            1DLC3325                    ATOM  3202                                                                              CG2                                                                               ILE 453                                                                               38.154                                                                             29.446                                                                             33.730                                                                             1.00                                                                              32.32            1DLC3326                    ATOM  3203                                                                              CD1                                                                               ILE 453                                                                               38.910                                                                             29.287                                                                             36.786                                                                             1.00                                                                              36.52            1DLC3327                    ATOM  3204                                                                              N  ASP 454                                                                               34.474                                                                             30.225                                                                             33.926                                                                             1.00                                                                              22.83            1DLC3328                    ATOM  3205                                                                              CA ASP 454                                                                               33.786                                                                             31.107                                                                             32.982                                                                             1.00                                                                              22.88            1DLC3329                    ATOM  3206                                                                              C  ASP 454                                                                               33.256                                                                             32.362                                                                             33.663                                                                             1.00                                                                              23.05            1DLC3330                    ATOM  3207                                                                              O  ASP 454                                                                               33.097                                                                             33.412                                                                             33.034                                                                             1.00                                                                              22.70            1DLC3331                    ATOM  3208                                                                              CB ASP 454                                                                               32.598                                                                             30.397                                                                             32.337                                                                             1.00                                                                              29.00            1DLC3332                    ATOM  3209                                                                              CG ASP 454                                                                               33.000                                                                             29.187                                                                             31.533                                                                             1.00                                                                              36.53            1DLC3333                    ATOM  3210                                                                              OD1                                                                               ASP 454                                                                               33.975                                                                             29.279                                                                             30.749                                                                             1.00                                                                              38.64            1DLC3334                    ATOM  3211                                                                              OD2                                                                               ASP 454                                                                               32.322                                                                             28.144                                                                             31.679                                                                             1.00                                                                              42.72            1DLC3335                    ATOM  3212                                                                              N  GLN 455                                                                               32.929                                                                             32.226                                                                             34.943                                                                             1.00                                                                              21.53            1DLC3336                    ATOM  3213                                                                              CA GLN 455                                                                               32.388                                                                             33.330                                                                             35.711                                                                             1.00                                                                              19.71            1DLC3337                    ATOM  3214                                                                              C  GLN 455                                                                               33.440                                                                             33.991                                                                             36.574                                                                             1.00                                                                              21.92            1DLC3338                    ATOM  3215                                                                              O  GLN 455                                                                               33.399                                                                             35.198                                                                             36.801                                                                             1.00                                                                              26.53            1DLC3339                    ATOM  3216                                                                              CB GLN 455                                                                               31.223                                                                             32.834                                                                             36.555                                                                             1.00                                                                              16.77            1DLC3340                    ATOM  3217                                                                              CG GLN 455                                                                               30.108                                                                             32.308                                                                             35.690                                                                             1.00                                                                              22.31            1DLC3341                    ATOM  3218                                                                              CD GLN 455                                                                               29.032                                                                             31.629                                                                             36.475                                                                             1.00                                                                              23.60            1DLC3342                    ATOM  3219                                                                              OE1                                                                               GLN 455                                                                               28.575                                                                             32.150                                                                             37.468                                                                             1.00                                                                              24.05            1DLC3343                    ATOM  3220                                                                              NE2                                                                               GLN 455                                                                               28.628                                                                             30.449                                                                             36.042                                                                             1.00                                                                              27.92            1DLC3344                    ATOM  3221                                                                              N  LEU 456                                                                               34.388                                                                             33.197                                                                             37.054                                                                             1.00                                                                              23.05            1DLC3345                    ATOM  3222                                                                              CA LEU 456                                                                               35.469                                                                             33.709                                                                             37.894                                                                             1.00                                                                              22.56            1DLC3346                    ATOM  3223                                                                              C  LEU 456                                                                               36.813                                                                             33.349                                                                             37.274                                                                             1.00                                                                              20.68            1DLC3347                    ATOM  3224                                                                              O  LEU 456                                                                               37.508                                                                             32.440                                                                             37.730                                                                             1.00                                                                              19.98            1DLC3348                    ATOM  3225                                                                              CB LEU 456                                                                               35.357                                                                             33.149                                                                             39.316                                                                             1.00                                                                              20.94            1DLC3349                    ATOM  3226                                                                              CG LEU 456                                                                               34.034                                                                             33.435                                                                             40.044                                                                             1.00                                                                              22.46            1DLC3350                    ATOM  3227                                                                              CD1                                                                               LEU 456                                                                               34.021                                                                             32.668                                                                             41.344                                                                             1.00                                                                              21.63            1DLC3351                    ATOM  3228                                                                              CD2                                                                               LEU 456                                                                               33.850                                                                             34.935                                                                             40.297                                                                             1.00                                                                              17.51            1DLC3352                    ATOM  3229                                                                              N  PRO 457                                                                               37.193                                                                             34.071                                                                             36.211                                                                             1.00                                                                              21.65            1DLC3353                    ATOM  3230                                                                              CA PRO 457                                                                               38.453                                                                             33.850                                                                             35.500                                                                             1.00                                                                              22.86            1DLC3354                    ATOM  3231                                                                              C  PRO 457                                                                               39.648                                                                             33.998                                                                             36.454                                                                             1.00                                                                              25.36            1DLC3355                    ATOM  3232                                                                              O  PRO 457                                                                               39.500                                                                             34.486                                                                             37.585                                                                             1.00                                                                              23.67            1DLC3356                    ATOM  3233                                                                              CB PRO 457                                                                               38.450                                                                             34.975                                                                             34.458                                                                             1.00                                                                              21.76            1DLC3357                    ATOM  3234                                                                              CG PRO 457                                                                               37.016                                                                             35.300                                                                             34.277                                                                             1.00                                                                              20.92            1DLC3358                    ATOM  3235                                                                              CD PRO 457                                                                               36.495                                                                             35.251                                                                             35.673                                                                             1.00                                                                              19.85            1DLC3359                    ATOM  3236                                                                              N  PRO 458                                                                               40.843                                                                             33.557                                                                             36.022                                                                             1.00                                                                              25.47            1DLC3360                    ATOM  3237                                                                              CA PRO 458                                                                               42.028                                                                             33.671                                                                             36.878                                                                             1.00                                                                              24.94            1DLC3361                    ATOM  3238                                                                              C  PRO 458                                                                               42.597                                                                             35.093                                                                             36.789                                                                             1.00                                                                              25.68            1DLC3362                    ATOM  3239                                                                              O  PRO 458                                                                               42.340                                                                             35.818                                                                             35.819                                                                             1.00                                                                              22.11            1DLC3363                    ATOM  3240                                                                              CB PRO 458                                                                               43.008                                                                             32.672                                                                             36.251                                                                             1.00                                                                              24.27            1DLC3364                    ATOM  3241                                                                              CG PRO 458                                                                               42.197                                                                             31.916                                                                             35.224                                                                             1.00                                                                              26.36            1DLC3365                    ATOM  3242                                                                              CD PRO 458                                                                               41.187                                                                             32.894                                                                             34.759                                                                             1.00                                                                              23.11            1DLC3366                    ATOM  3243                                                                              N  GLU 459                                                                               43.343                                                                             35.504                                                                             37.809                                                                             1.00                                                                              26.71            1DLC3367                    ATOM  3244                                                                              CA GLU 459                                                                               43.950                                                                             36.827                                                                             37.788                                                                             1.00                                                                              33.63            1DLC3368                    ATOM  3245                                                                              C  GLU 459                                                                               44.956                                                                             36.884                                                                             36.646                                                                             1.00                                                                              37.69            1DLC3369                    ATOM  3246                                                                              O  GLU 459                                                                               45.090                                                                             37.907                                                                             35.971                                                                             1.00                                                                              37.94            1DLC3370                    ATOM  3247                                                                              CB GLU 459                                                                               44.654                                                                             37.129                                                                             39.106                                                                             1.00                                                                              34.45            1DLC3371                    ATOM  3248                                                                              CG GLU 459                                                                               43.711                                                                             37.364                                                                             40.269                                                                             1.00                                                                              38.75            1DLC3372                    ATOM  3249                                                                              CD GLU 459                                                                               44.438                                                                             37.530                                                                             41.590                                                                             1.00                                                                              40.23            1DLC3373                    ATOM  3250                                                                              OE1                                                                               GLU 459                                                                               45.676                                                                             37.372                                                                             41.614                                                                             1.00                                                                              44.97            1DLC3374                    ATOM  3251                                                                              OE2                                                                               GLU 459                                                                               43.772                                                                             37.811                                                                             42.610                                                                             1.00                                                                              41.43            1DLC3375                    ATOM  3252                                                                              N  THR 460                                                                               45.640                                                                             35.765                                                                             36.419                                                                             1.00                                                                              42.42            1DLC3376                    ATOM  3253                                                                              CA THR 460                                                                               46.634                                                                             35.668                                                                             35.352                                                                             1.00                                                                              46.99            1DLC3377                    ATOM  3254                                                                              C  THR 460                                                                               46.516                                                                             34.423                                                                             34.495                                                                             1.00                                                                              48.85            1DLC3378                    ATOM  3255                                                                              O  THR 460                                                                               46.385                                                                             33.310                                                                             35.006                                                                             1.00                                                                              49.59            1DLC3379                    ATOM  3256                                                                              CB THR 460                                                                               48.091                                                                             35.669                                                                             35.892                                                                             1.00                                                                              47.16            1DLC3380                    ATOM  3257                                                                              OG1                                                                               THR 460                                                                               48.212                                                                             34.744                                                                             36.980                                                                             1.00                                                                              48.60            1DLC3381                    ATOM  3258                                                                              CG2                                                                               THR 460                                                                               48.502                                                                             37.051                                                                             36.348                                                                             1.00                                                                              52.25            1DLC3382                    ATOM  3259                                                                              N  THR 461                                                                               46.583                                                                             34.625                                                                             33.185                                                                             1.00                                                                              52.04            1DLC3383                    ATOM  3260                                                                              CA THR 461                                                                               46.555                                                                             33.524                                                                             32.231                                                                             1.00                                                                              55.43            1DLC3384                    ATOM  3261                                                                              C  THR 461                                                                               48.009                                                                             33.128                                                                             31.950                                                                             1.00                                                                              59.08            1DLC3385                    ATOM  3262                                                                              O  THR 461                                                                               48.290                                                                             32.305                                                                             31.077                                                                             1.00                                                                              62.04            1DLC3386                    ATOM  3263                                                                              CB THR 461                                                                               45.898                                                                             33.942                                                                             30.914                                                                             1.00                                                                              55.22            1DLC3387                    ATOM  3264                                                                              OG1                                                                               THR 461                                                                               46.513                                                                             35.143                                                                             30.440                                                                             1.00                                                                              57.54            1DLC3388                    ATOM  3265                                                                              CG2                                                                               THR 461                                                                               44.419                                                                             34.183                                                                             31.113                                                                             1.00                                                                              54.73            1DLC3389                    ATOM  3266                                                                              N  ASP 462                                                                               48.929                                                                             33.768                                                                             32.668                                                                             1.00                                                                              61.13            1DLC3390                    ATOM  3267                                                                              CA ASP 462                                                                               50.355                                                                             33.499                                                                             32.542                                                                             1.00                                                                              63.77            1DLC3391                    ATOM  3268                                                                              C  ASP 462                                                                               50.749                                                                             32.240                                                                             33.319                                                                             1.00                                                                              62.37            1DLC3392                    ATOM  3269                                                                              O  ASP 462                                                                               51.321                                                                             31.308                                                                             32.757                                                                             1.00                                                                              63.78            1DLC3393                    ATOM  3270                                                                              CB ASP 462                                                                               51.162                                                                             34.700                                                                             33.054                                                                             1.00                                                                              70.21            1DLC3394                    ATOM  3271                                                                              CG ASP 462                                                                               51.831                                                                             35.485                                                                             31.930                                                                             1.00                                                                              76.55            1DLC3395                    ATOM  3272                                                                              OD1                                                                               ASP 462                                                                               51.191                                                                             35.686                                                                             30.871                                                                             1.00                                                                              79.02            1DLC3396                    ATOM  3273                                                                              OD2                                                                               ASP 462                                                                               53.004                                                                             35.901                                                                             32.110                                                                             1.00                                                                              79.69            1DLC3397                    ATOM  3274                                                                              N  GLU 463                                                                               50.437                                                                             32.224                                                                             34.612                                                                             1.00                                                                              60.14            1DLC3398                    ATOM  3275                                                                              CA GLU 463                                                                               50.752                                                                             31.090                                                                             35.483                                                                             1.00                                                                              58.33            1DLC3399                    ATOM  3276                                                                              C  GLU 463                                                                               49.703                                                                             29.968                                                                             35.441                                                                             1.00                                                                              55.57            1DLC3400                    ATOM  3277                                                                              O  GLU 463                                                                               48.610                                                                             30.140                                                                             34.890                                                                             1.00                                                                              57.13            1DLC3401                    ATOM  3278                                                                              CB GLU 463                                                                               50.886                                                                             31.575                                                                             36.922                                                                             1.00                                                                              60.04            1DLC3402                    ATOM  3279                                                                              CG GLU 463                                                                               51.932                                                                             32.639                                                                             37.123                                                                             1.00                                                                              69.89            1DLC3403                    ATOM  3280                                                                              CD GLU 463                                                                               52.244                                                                             32.859                                                                             38.594                                                                             1.00                                                                              77.10            1DLC3404                    ATOM  3281                                                                              OE1                                                                               GLU 463                                                                               51.402                                                                             33.458                                                                             39.308                                                                             1.00                                                                              79.81            1DLC3405                    ATOM  3282                                                                              OE2                                                                               GLU 463                                                                               53.331                                                                             32.418                                                                             39.041                                                                             1.00                                                                              81.43            1DLC3406                    ATOM  3283                                                                              N  PRO 464                                                                               50.034                                                                             28.785                                                                             35.996                                                                             1.00                                                                              51.32            1DLC3407                    ATOM  3284                                                                              CA PRO 464                                                                               49.045                                                                             27.702                                                                             35.982                                                                             1.00                                                                              47.85            1DLC3408                    ATOM  3285                                                                              C  PRO 464                                                                               47.898                                                                             28.044                                                                             36.955                                                                             1.00                                                                              44.75            1DLC3409                    ATOM  3286                                                                              O  PRO 464                                                                               48.124                                                                             28.725                                                                             37.963                                                                             1.00                                                                              41.10            1DLC3410                    ATOM  3287                                                                              CB PRO 464                                                                               49.867                                                                             26.486                                                                             36.435                                                                             1.00                                                                              47.06            1DLC3411                    ATOM  3288                                                                              CG PRO 464                                                                               50.929                                                                             27.087                                                                             37.300                                                                             1.00                                                                              46.21            1DLC3412                    ATOM  3289                                                                              CD PRO 464                                                                               51.328                                                                             28.309                                                                             36.521                                                                             1.00                                                                              48.64            1DLC3413                    ATOM  3290                                                                              N  LEU 465                                                                               46.686                                                                             27.570                                                                             36.657                                                                             1.00                                                                              41.80            1DLC3414                    ATOM  3291                                                                              CA LEU 465                                                                               45.497                                                                             27.853                                                                             37.475                                                                             1.00                                                                              37.33            1DLC3415                    ATOM  3292                                                                              C  LEU 465                                                                               45.658                                                                             27.777                                                                             38.992                                                                             1.00                                                                              35.76            1DLC3416                    ATOM  3293                                                                              O  LEU 465                                                                               45.174                                                                             28.655                                                                             39.707                                                                             1.00                                                                              34.89            1DLC3417                    ATOM  3294                                                                              CB LEU 465                                                                               44.311                                                                             26.981                                                                             37.047                                                                             1.00                                                                              38.95            1DLC3418                    ATOM  3295                                                                              CG LEU 465                                                                               43.043                                                                             27.695                                                                             36.542                                                                             1.00                                                                              40.98            1DLC3419                    ATOM  3296                                                                              CD1                                                                               LEU 465                                                                               41.879                                                                             26.706                                                                             36.476                                                                             1.00                                                                              41.37            1DLC3420                    ATOM  3297                                                                              CD2                                                                               LEU 465                                                                               42.673                                                                             28.853                                                                             37.448                                                                             1.00                                                                              38.54            1DLC3421                    ATOM  3298                                                                              N  GLU 466                                                                               46.341                                                                             26.749                                                                             39.489                                                                             1.00                                                                              31.43            1DLC3422                    ATOM  3299                                                                              CA GLU 466                                                                               46.534                                                                             26.620                                                                             40.930                                                                             1.00                                                                              32.27            1DLC3423                    ATOM  3300                                                                              C  GLU 466                                                                               47.368                                                                             27.763                                                                             41.518                                                                             1.00                                                                              31.84            1DLC3424                    ATOM  3301                                                                              O  GLU 466                                                                               47.493                                                                             27.895                                                                             42.737                                                                             1.00                                                                              33.28            1DLC3425                    ATOM  3302                                                                              CB GLU 466                                                                               47.144                                                                             25.263                                                                             41.300                                                                             1.00                                                                              35.86            1DLC3426                    ATOM  3303                                                                              CG GLU 466                                                                               48.603                                                                             25.078                                                                             40.917                                                                             1.00                                                                              41.48            1DLC3427                    ATOM  3304                                                                              CD GLU 466                                                                               48.789                                                                             24.358                                                                             39.595                                                                             1.00                                                                              43.01            1DLC3428                    ATOM  3305                                                                              OE1                                                                               GLU 466                                                                               48.001                                                                             24.585                                                                             38.650                                                                             1.00                                                                              43.46            1DLC3429                    ATOM  3306                                                                              OE2                                                                               GLU 466                                                                               49.737                                                                             23.552                                                                             39.506                                                                             1.00                                                                              49.70            1DLC3430                    ATOM  3307                                                                              N  LYS 467                                                                               47.959                                                                             28.568                                                                             40.643                                                                             1.00                                                                              30.87            1DLC3431                    ATOM  3308                                                                              CA LYS 467                                                                               48.753                                                                             29.716                                                                             41.071                                                                             1.00                                                                              34.88            1DLC3432                    ATOM  3309                                                                              C  LYS 467                                                                               48.053                                                                             31.033                                                                             40.739                                                                             1.00                                                                              30.95            1DLC3433                    ATOM  3310                                                                              O  LYS 467                                                                               48.050                                                                             31.955                                                                             41.537                                                                             1.00                                                                              34.01            1DLC3434                    ATOM  3311                                                                              CB LYS 467                                                                               50.126                                                                             29.727                                                                             40.395                                                                             1.00                                                                              41.82            1DLC3435                    ATOM  3312                                                                              CG LYS 467                                                                               51.091                                                                             28.619                                                                             40.784                                                                             1.00                                                                              48.67            1DLC3436                    ATOM  3313                                                                              CD LYS 467                                                                               52.383                                                                             28.821                                                                             39.991                                                                             1.00                                                                              59.85            1DLC3437                    ATOM  3314                                                                              CE LYS 467                                                                               53.387                                                                             27.682                                                                             40.140                                                                             1.00                                                                              63.85            1DLC3438                    ATOM  3315                                                                              NZ LYS 467                                                                               54.585                                                                             27.912                                                                             39.262                                                                             1.00                                                                              63.42            1DLC3439                    ATOM  3316                                                                              N  GLY 468                                                                               47.462                                                                             31.113                                                                             39.553                                                                             1.00                                                                              29.04            1DLC3440                    ATOM  3317                                                                              CA GLY 468                                                                               46.806                                                                             32.342                                                                             39.136                                                                             1.00                                                                              28.69            1DLC3441                    ATOM  3318                                                                              C  GLY 468                                                                               45.319                                                                             32.552                                                                             39.384                                                                             1.00                                                                              27.26            1DLC3442                    ATOM  3319                                                                              O  GLY 468                                                                               44.794                                                                             33.614                                                                             39.036                                                                             1.00                                                                              26.73            1DLC3443                    ATOM  3320                                                                              N  GLY 468                                                                               44.640                                                                             31.570                                                                             39.977                                                                             1.00                                                                              23.94            1DLC3444                    ATOM  3321                                                                              CA TYR 469                                                                               43.207                                                                             31.689                                                                             40.243                                                                             1.00                                                                              23.65            1DLC3445                    ATOM  3322                                                                              C  TYR 469                                                                               42.874                                                                             32.954                                                                             41.064                                                                             1.00                                                                              26.78            1DLC3446                    ATOM  3323                                                                              O  TYR 469                                                                               43.728                                                                             33.498                                                                             41.762                                                                             1.00                                                                              29.85            1DLC3447                    ATOM  3324                                                                              CB TYR 469                                                                               42.687                                                                             30.427                                                                             40.931                                                                             1.00                                                                              18.50            1DLC3448                    ATOM  3325                                                                              CG TYR 469                                                                               43.069                                                                             30.300                                                                             42.384                                                                             1.00                                                                              18.68            1DLC3449                    ATOM  3326                                                                              CD1                                                                               TYR 469                                                                               44.253                                                                             29.668                                                                             42.771                                                                             1.00                                                                              18.59            1DLC3450                    ATOM  3327                                                                              CD2                                                                               TYR 469                                                                               42.228                                                                             30.789                                                                             43.381                                                                             1.00                                                                              17.48            1DLC3451                    ATOM  3328                                                                              CE1                                                                               TYR 469                                                                               44.581                                                                             29.526                                                                             44.119                                                                             1.00                                                                              18.20            1DLC3452                    ATOM  3329                                                                              CE2                                                                               TYR 469                                                                               42.543                                                                             30.655                                                                             44.722                                                                             1.00                                                                              17.54            1DLC3453                    ATOM  3330                                                                              CZ TYR 469                                                                               43.715                                                                             30.025                                                                             45.088                                                                             1.00                                                                              19.23            1DLC3454                    ATOM  3331                                                                              OH TYR 469                                                                               43.999                                                                             29.900                                                                             46.427                                                                             1.00                                                                              24.58            1DLC3455                    ATOM  3332                                                                              N  SER 470                                                                               41.637                                                                             33.430                                                                             40.970                                                                             1.00                                                                              26.56            1DLC3456                    ATOM  3333                                                                              CA SER 470                                                                               41.235                                                                             34.646                                                                             41.684                                                                             1.00                                                                              26.36            1DLC3457                    ATOM  3334                                                                              C  SER 470                                                                               40.278                                                                             34.460                                                                             42.861                                                                             1.00                                                                              25.81            1DLC3458                    ATOM  3335                                                                              O  SER 470                                                                               40.118                                                                             35.364                                                                             43.689                                                                             1.00                                                                              27.24            1DLC3459                    ATOM  3336                                                                              CB SER 470                                                                               40.604                                                                             35.631                                                                             40.701                                                                             1.00                                                                              26.16            1DLC3460                    ATOM  3337                                                                              OG SER 470                                                                               39.445                                                                             35.070                                                                             40.106                                                                             1.00                                                                              24.14            1DLC3461                    ATOM  3338                                                                              N  HIS 471                                                                               39.623                                                                             33.305                                                                             42.926                                                                             1.00                                                                              24.96            1DLC3462                    ATOM  3339                                                                              CA HIS 471                                                                               38.656                                                                             33.025                                                                             43.986                                                                             1.00                                                                              22.21            1DLC3463                    ATOM  3340                                                                              C  HIS 471                                                                               38.652                                                                             31.573                                                                             44.426                                                                             1.00                                                                              20.34            1DLC3464                    ATOM  3341                                                                              O  HIS 471                                                                               39.004                                                                             30.685                                                                             43.666                                                                             1.00                                                                              20.23            1DLC3465                    ATOM  3342                                                                              CB HIS 471                                                                               37.234                                                                             33.342                                                                             43.501                                                                             1.00                                                                              24.72            1DLC3466                    ATOM  3343                                                                              CG HIS 471                                                                               36.951                                                                             34.800                                                                             43.306                                                                             1.00                                                                              24.47            1DLC3467                    ATOM  3344                                                                              ND1                                                                               HIS 471                                                                               37.260                                                                             35.474                                                                             42.142                                                                             1.00                                                                              22.67            1DLC3468                    ATOM  3345                                                                              CD2                                                                               HIS 471                                                                               36.328                                                                             35.699                                                                             44.106                                                                             1.00                                                                              22.96            1DLC3469                    ATOM  3346                                                                              CE1                                                                               HIS 471                                                                               36.835                                                                             36.720                                                                             24.232                                                                             1.00                                                                              22.12            1DLC3470                    ATOM  3347                                                                              NE2                                                                               HIS 471                                                                               36.265                                                                             36.881                                                                             43.415                                                                             1.00                                                                              21.11            1DLC3471                    ATOM  3348                                                                              N  GLN 472                                                                               38.180                                                                             31.334                                                                             45.638                                                                             1.00                                                                              19.76            1DLC3472                    ATOM  3349                                                                              CA GLN 472                                                                               38.079                                                                             29.979                                                                             46.155                                                                             1.00                                                                              20.82            1DLC3473                    ATOM  3350                                                                              C  GLN 472                                                                               36.680                                                                             29.724                                                                             46.709                                                                             1.00                                                                              22.36            1DLC3474                    ATOM  3351                                                                              O  GLN 472                                                                               35.976                                                                             30.664                                                                             47.097                                                                             1.00                                                                              22.13            1DLC3475                    ATOM  3352                                                                              CB GLN 472                                                                               39.120                                                                             29.740                                                                             47.230                                                                             1.00                                                                              22.23            1DLC3476                    ATOM  3353                                                                              CG GLN 472                                                                               39.115                                                                             30.769                                                                             48.313                                                                             1.00                                                                              29.71            1DLC3477                    ATOM  3354                                                                              CD GLN 472                                                                               40.248                                                                             30.552                                                                             49.280                                                                             1.00                                                                              40.11            1DLC3478                    ATOM  3355                                                                              OE1                                                                               GLN 472                                                                               40.174                                                                             29.680                                                                             50.151                                                                             1.00                                                                              41.87            1DLC3479                    ATOM  3356                                                                              NE2                                                                               GLN 472                                                                               41.326                                                                             31.317                                                                             49.116                                                                             1.00                                                                              44.52            1DLC3480                    ATOM  3357                                                                              N  LEU 473                                                                               36.277                                                                             28.455                                                                             46.731                                                                             1.00                                                                              23.05            1DLC3481                    ATOM  3358                                                                              CA LEU 473                                                                               34.959                                                                             28.054                                                                             47.221                                                                             1.00                                                                              20.06            1DLC3482                    ATOM  3359                                                                              C  LEU 473                                                                               34.794                                                                             28.248                                                                             48.725                                                                             1.00                                                                              20.03            1DLC3483                    ATOM  3360                                                                              O  LEU 473                                                                               35.637                                                                             27.833                                                                             49.517                                                                             1.00                                                                              19.02            1DLC3484                    ATOM  3361                                                                              CB LEU 473                                                                               34.678                                                                             26.587                                                                             46.876                                                                             1.00                                                                              21.51            1DLC3485                    ATOM  3362                                                                              CG LEU 473                                                                               33.401                                                                             26.198                                                                             46.118                                                                             1.00                                                                              22.58            1DLC3486                    ATOM  3363                                                                              CD1                                                                               LEU 473                                                                               33.188                                                                             24.714                                                                             46.270                                                                             1.00                                                                              20.29            1DLC3487                    ATOM  3364                                                                              CD2                                                                               LEU 473                                                                               32.181                                                                             26.940                                                                             46.633                                                                             1.00                                                                              20.63            1DLC3488                    ATOM  3365                                                                              N  ASN 474                                                                               33.685                                                                             28.862                                                                             49.108                                                                             1.00                                                                              20.98            1DLC3489                    ATOM  3366                                                                              CA ASN 474                                                                               33.394                                                                             29.103                                                                             50.508                                                                             1.00                                                                              22.93            1DLC3490                    ATOM  3367                                                                              C  ASN 474                                                                               32.087                                                                             28.434                                                                             50.936                                                                             1.00                                                                              22.97            1DLC3491                    ATOM  3368                                                                              O  ASN 474                                                                               31.975                                                                             27.922                                                                             52.056                                                                             1.00                                                                              23.74            1DLC3492                    ATOM  3369                                                                              CB ASN 474                                                                               33.327                                                                             30.612                                                                             50.777                                                                             1.00                                                                              24.38            1DLC3493                    ATOM  3370                                                                              CG ASN 474                                                                               33.068                                                                             30.941                                                                             52.247                                                                             1.00                                                                              29.78            1DLC3494                    ATOM  3371                                                                              OD1                                                                               ASN 474                                                                               32.237                                                                             31.780                                                                             52.563                                                                             1.00                                                                              38.30            1DLC3495                    ATOM  3372                                                                              ND2                                                                               ASN 474                                                                               33.789                                                                             30.298                                                                             53.140                                                                             1.00                                                                              29.37            1DLC3496                    ATOM  3373                                                                              N  TYR 475                                                                               31.119                                                                             28.383                                                                             50.028                                                                             1.00                                                                              21.61            1DLC3497                    ATOM  3374                                                                              CA TYR 475                                                                               29.824                                                                             27.812                                                                             50.376                                                                             1.00                                                                              21.74            1DLC3498                    ATOM  3375                                                                              C  TYR 475                                                                               29.081                                                                             27.125                                                                             49.244                                                                             1.00                                                                              20.48            1DLC3499                    ATOM  3376                                                                              O  TYR 475                                                                               29.219                                                                             27.472                                                                             48.069                                                                             1.00                                                                              18.90            1DLC3500                    ATOM  3377                                                                              CB TYR 475                                                                               28.922                                                                             28.910                                                                             50.958                                                                             1.00                                                                              22.80            1DLC3501                    ATOM  3378                                                                              CG TYR 475                                                                               28.050                                                                             28.481                                                                             52.117                                                                             1.00                                                                              23.56            1DLC3502                    ATOM  3379                                                                              CD1                                                                               TYR 475                                                                               28.601                                                                             28.258                                                                             53.379                                                                             1.00                                                                              27.52            1DLC3503                    ATOM  3380                                                                              CD2                                                                               TYR 475                                                                               26.672                                                                             28.324                                                                             51.963                                                                             1.00                                                                              23.00            1DLC3504                    ATOM  3381                                                                              CE1                                                                               TYR 475                                                                               27.802                                                                             27.895                                                                             54.464                                                                             1.00                                                                              26.40            1DLC3505                    ATOM  3382                                                                              CE2                                                                               TYR 475                                                                               25.858                                                                             27.958                                                                             53.043                                                                             1.00                                                                              24.16            1DLC3506                    ATOM  3383                                                                              CZ TYR 475                                                                               26.430                                                                             27.746                                                                             54.291                                                                             1.00                                                                              25.06            1DLC3507                    ATOM  3384                                                                              OH TYR 475                                                                               25.643                                                                             27.405                                                                             55.375                                                                             1.00                                                                              26.34            1DLC3508                    ATOM  3385                                                                              N  VAL 476                                                                               28.273                                                                             26.150                                                                             49.638                                                                             1.00                                                                              21.63            1DLC3509                    ATOM  3386                                                                              CA VAL 476                                                                               27.444                                                                             25.379                                                                             48.724                                                                             1.00                                                                              22.28            1DLC3510                    ATOM  3387                                                                              C  VAL 476                                                                               26.046                                                                             25.309                                                                             49.355                                                                             1.00                                                                              23.25            1DLC3511                    ATOM  3388                                                                              O  VAL 476                                                                               25.905                                                                             25.032                                                                             50.546                                                                             1.00                                                                              22.42            1DLC3512                    ATOM  3389                                                                              CB VAL 476                                                                               28.026                                                                             23.958                                                                             48.499                                                                             1.00                                                                              19.04            1DLC3513                    ATOM  3390                                                                              CG1                                                                               VAL 476                                                                               27.025                                                                             23.077                                                                             47.813                                                                             1.00                                                                              20.37            1DLC3514                    ATOM  3391                                                                              CG2                                                                               VAL 476                                                                               29.269                                                                             24.040                                                                             47.640                                                                             1.00                                                                              20.33            1DLC3515                    ATOM  3392                                                                              N  MET 477                                                                               25.026                                                                             25.652                                                                             48.575                                                                             1.00                                                                              22.47            1DLC3516                    ATOM  3393                                                                              CA MET 477                                                                               23.655                                                                             25.627                                                                             49.069                                                                             1.00                                                                              22.92            1DLC3517                    ATOM  3394                                                                              C  MET 477                                                                               22.722                                                                             25.110                                                                             47.973                                                                             1.00                                                                              23.63            1DLC3518                    ATOM  3395                                                                              O  MET 477                                                                               22.819                                                                             25.531                                                                             46.825                                                                             1.00                                                                              24.06            1DLC3519                    ATOM  3396                                                                              CB MET 477                                                                               23.246                                                                             27.030                                                                             49.517                                                                             1.00                                                                              24.95            1DLC3520                    ATOM  3397                                                                              CG MET 477                                                                               22.027                                                                             27.076                                                                             50.408                                                                             1.00                                                                              34.31            1DLC3521                    ATOM  3398                                                                              SD MET 477                                                                               21.578                                                                             28.761                                                                             50.913                                                                             1.00                                                                              36.69            1DLC3522                    ATOM  3399                                                                              CE MET 477                                                                               22.689                                                                             29.016                                                                             52.281                                                                             1.00                                                                              38.04            1DLC3523                    ATOM  3400                                                                              N  CYS 478                                                                               21.870                                                                             24.150                                                                             48.327                                                                             1.00                                                                              25.18            1DLC3524                    ATOM  3401                                                                              CA CYS 478                                                                               20.912                                                                             23.551                                                                             47.390                                                                             1.00                                                                              23.36            1DLC3525                    ATOM  3402                                                                              C  CYS 478                                                                               19.507                                                                             24.106                                                                             47.568                                                                             1.00                                                                              23.41            1DLC3526                    ATOM  3403                                                                              O  CYS 478                                                                               18.970                                                                             24.102                                                                             48.673                                                                             1.00                                                                              23.01            1DLC3527                    ATOM  3404                                                                              CB CYS 478                                                                               20.843                                                                             22.029                                                                             47.564                                                                             1.00                                                                              21.73            1DLC3528                    ATOM  3405                                                                              SG CYS 478                                                                               22.219                                                                             21.086                                                                             46.881                                                                             1.00                                                                              24.07            1DLC3529                    ATOM  3406                                                                              N  PHE 479                                                                               18.918                                                                             24.585                                                                             46.481                                                                             1.00                                                                              21.93            1DLC3530                    ATOM  3407                                                                              CA PHE 479                                                                               17.563                                                                             25.118                                                                             46.513                                                                             1.00                                                                              19.16            1DLC3531                    ATOM  3408                                                                              C  PHE 479                                                                               16.629                                                                             24.149                                                                             45.814                                                                             1.00                                                                              20.36            1DLC3532                    ATOM  3409                                                                              O  PHE 479                                                                               17.032                                                                             23.431                                                                             44.897                                                                             1.00                                                                              19.20            1DLC3533                    ATOM  3410                                                                              CB PHE 479                                                                               17.496                                                                             26.483                                                                             45.831                                                                             1.00                                                                              16.90            1DLC3534                    ATOM  3411                                                                              CG PHE 479                                                                               18.194                                                                             27.563                                                                             46.592                                                                             1.00                                                                              19.07            1DLC3535                    ATOM  3412                                                                              CD1                                                                               PHE 479                                                                               17.550                                                                             28.229                                                                             47.625                                                                             1.00                                                                              20.04            1DLC3536                    ATOM  3413                                                                              CD2                                                                               PHE 479                                                                               19.509                                                                             27.891                                                                             46.308                                                                             1.00                                                                              17.03            1DLC3537                    ATOM  3414                                                                              CE1                                                                               PHE 479                                                                               18.210                                                                             29.207                                                                             48.368                                                                             1.00                                                                              22.59            1DLC3538                    ATOM  3415                                                                              CE2                                                                               PHE 479                                                                               20.173                                                                             28.866                                                                             47.044                                                                             1.00                                                                              23.10            1DLC3539                    ATOM  3416                                                                              CZ PHE 479                                                                               19.525                                                                             29.524                                                                             48.075                                                                             1.00                                                                              18.71            1DLC3540                    ATOM  3417                                                                              N  LEU 480                                                                               15.384                                                                             24.102                                                                             46.269                                                                             1.00                                                                              21.81            1DLC3541                    ATOM  3418                                                                              CA LEU 480                                                                               14.402                                                                             23.219                                                                             45.661                                                                             1.00                                                                              19.96            1DLC3542                    ATOM  3419                                                                              C  LEU 480                                                                               13.587                                                                             23.952                                                                             44.611                                                                             1.00                                                                              20.47            1DLC3543                    ATOM  3420                                                                              O  LEU 480                                                                               13.229                                                                             25.117                                                                             44.798                                                                             1.00                                                                              22.01            1DLC3544                    ATOM  3421                                                                              CB LEU 480                                                                               13.474                                                                             22.629                                                                             46.719                                                                             1.00                                                                              16.36            1DLC3545                    ATOM  3422                                                                              CG LEU 480                                                                               14.071                                                                             21.574                                                                             47.653                                                                             1.00                                                                              18.20            1DLC3546                    ATOM  3423                                                                              CD1                                                                               LEU 480                                                                               13.045                                                                             21.170                                                                             48.675                                                                             1.00                                                                              16.09            1DLC3547                    ATOM  3424                                                                              CD2                                                                               LEU 480                                                                               14.535                                                                             20.367                                                                             46.863                                                                             1.00                                                                              17.11            1DLC3548                    ATOM  3425                                                                              N  MET 481                                                                               13.375                                                                             23.300                                                                             43.473                                                                             1.00                                                                              19.08            1DLC3549                    ATOM  3426                                                                              CA MET 481                                                                               12.557                                                                             23.875                                                                             42.411                                                                             1.00                                                                              21.22            1DLC3550                    ATOM  3427                                                                              C  MET 481                                                                               11.091                                                                             23.844                                                                             42.867                                                                             1.00                                                                              24.48            1DLC3551                    ATOM  3428                                                                              O  MET 481                                                                               10.729                                                                             23.084                                                                             43.772                                                                             1.00                                                                              25.50            1DLC3552                    ATOM  3429                                                                              CB MET 481                                                                               12.674                                                                             23.055                                                                             41.133                                                                             1.00                                                                              18.69            1DLC3553                    ATOM  3430                                                                              CG MET 481                                                                               14.002                                                                             23.129                                                                             40.458                                                                             1.00                                                                              20.79            1DLC3554                    ATOM  3431                                                                              SD MET 481                                                                               13.988                                                                             22.032                                                                             39.060                                                                             1.00                                                                              25.38            1DLC3555                    ATOM  3432                                                                              CE MET 481                                                                               15.738                                                                             21.837                                                                             38.753                                                                             1.00                                                                              21.04            1DLC3556                    ATOM  3433                                                                              N  GLN 482                                                                               10.251                                                                             24.662                                                                             42.241                                                                             1.00                                                                              25.74            1DLC3557                    ATOM  3434                                                                              CA GLN 482                                                                               8.836                                                                              24.705                                                                             42.579                                                                             1.00                                                                              24.89            1DLC3558                    ATOM  3435                                                                              C  GLN 482                                                                               8.143                                                                              23.390                                                                             42.282                                                                             1.00                                                                              26.77            1DLC3559                    ATOM  3436                                                                              O  GLN 482                                                                               8.469                                                                              22.713                                                                             41.311                                                                             1.00                                                                              26.04            1DLC3560                    ATOM  3437                                                                              CB GLN 482                                                                               8.153                                                                              25.834                                                                             41.840                                                                             1.00                                                                              22.45            1DLC3561                    ATOM  3438                                                                              CG GLN 482                                                                               8.516                                                                              27.182                                                                             42.390                                                                             1.00                                                                              24.04            1DLC3562                    ATOM  3439                                                                              CD GLN 482                                                                               7.592                                                                              28.241                                                                             41.888                                                                             1.00                                                                              25.93            1DLC3563                    ATOM  3440                                                                              OE1                                                                               GLN 482                                                                               6.758                                                                              28.740                                                                             42.630                                                                             1.00                                                                              33.56            1DLC3564                    ATOM  3441                                                                              NE2                                                                               GLN 482                                                                               7.697                                                                              28.565                                                                             40.617                                                                             1.00                                                                              24.90            1DLC3565                    ATOM  3442                                                                              N  GLY 483                                                                               7.200                                                                              23.017                                                                             43.141                                                                             1.00                                                                              31.29            1DLC3566                    ATOM  3443                                                                              CA GLY 483                                                                               6.502                                                                              21.756                                                                             42.960                                                                             1.00                                                                              34.89            1DLC3567                    ATOM  3444                                                                              C  GLY 483                                                                               7.529                                                                              20.643                                                                             42.974                                                                             1.00                                                                              38.13            1DLC3568                    ATOM  3445                                                                              O  GLY 483                                                                               7.338                                                                              19.585                                                                             42.382                                                                             1.00                                                                              41.30            1DLC3569                    ATOM  3446                                                                              N  SER 484                                                                               8.644                                                                              20.928                                                                             43.639                                                                             1.00                                                                              40.46            1DLC3570                    ATOM  3447                                                                              CA SER 484                                                                               9.781                                                                              20.027                                                                             43.760                                                                             1.00                                                                              39.19            1DLC3571                    ATOM  3448                                                                              C  SER 484                                                                               10.047                                                                             19.110                                                                             42.574                                                                             1.00                                                                              35.89            1DLC3572                    ATOM  3449                                                                              O  SER 484                                                                               9.982                                                                              17.891                                                                             42.682                                                                             1.00                                                                              34.78            1DLC3573                    ATOM  3450                                                                              CB SER 484                                                                               9.716                                                                              19.258                                                                             45.070                                                                             1.00                                                                              44.00            1DLC3574                    ATOM  3451                                                                              OG SER 484                                                                               9.864                                                                              20.160                                                                             46.158                                                                             1.00                                                                              49.80            1DLC3575                    ATOM  3452                                                                              N  ARG 485                                                                               10.322                                                                             19.728                                                                             41.430                                                                             1.00                                                                              34.10            1DLC3576                    ATOM  3453                                                                              CA ARG 485                                                                               10.639                                                                             18.998                                                                             40.212                                                                             1.00                                                                              33.89            1DLC3577                    ATOM  3454                                                                              C  ARG 485                                                                               12.155                                                                             18.734                                                                             40.152                                                                             1.00                                                                              34.69            1DLC3578                    ATOM  3455                                                                              O  ARG 485                                                                               12.630                                                                             17.971                                                                             39.305                                                                             1.00                                                                              36.50            1DLC3579                    ATOM  3456                                                                              CB ARG 485                                                                               10.197                                                                             19.800                                                                             38.983                                                                             1.00                                                                              33.16            1DLC3580                    ATOM  3457                                                                              CG ARG 485                                                                               10.266                                                                             19.019                                                                             37.669                                                                             1.00                                                                              36.98            1DLC3581                    ATOM  3458                                                                              CD ARG 485                                                                               9.882                                                                              19.889                                                                             36.485                                                                             1.00                                                                              41.59            1DLC3582                    ATOM  3459                                                                              NE ARG 485                                                                               8.680                                                                              19.445                                                                             35.770                                                                             1.00                                                                              42.72            1DLC3583                    ATOM  3460                                                                              CZ ARG 485                                                                               7.505                                                                              19.169                                                                             36.335                                                                             1.00                                                                              44.05            1DLC3584                    ATOM  3461                                                                              NH1                                                                               ARG 485                                                                               7.332                                                                              19.265                                                                             37.647                                                                             1.00                                                                              44.99            1DLC3585                    ATOM  3462                                                                              NH2                                                                               ARG 485                                                                               6.470                                                                              18.863                                                                             35.569                                                                             1.00                                                                              47.30            1DLC3586                    ATOM  3463                                                                              N  GLY 486                                                                               12.910                                                                             19.365                                                                             41.052                                                                             1.00                                                                              32.23            1DLC3587                    ATOM  3464                                                                              CA GLY 486                                                                               14.352                                                                             19.174                                                                             41.068                                                                             1.00                                                                              29.57            1DLC3588                    ATOM  3465                                                                              C  GLY 486                                                                               15.115                                                                             20.016                                                                             42.078                                                                             1.00                                                                              28.60            1DLC3589                    ATOM  3466                                                                              O  GLY 486                                                                               14.511                                                                             20.692                                                                             42.919                                                                             1.00                                                                              25.84            1DLC3590                    ATOM  3467                                                                              N  THR 487                                                                               16.443                                                                             19.992                                                                             41.966                                                                             1.00                                                                              25.86            1DLC3591                    ATOM  3468                                                                              A  THR 487                                                                               17.337                                                                             20.732                                                                             42.862                                                                             1.00                                                                              24.67            1DLC3592                    ATOM  3469                                                                              C  THR 487                                                                               18.295                                                                             21.665                                                                             42.121                                                                             1.00                                                                              25.25            1DLC3593                    ATOM  3470                                                                              O  THR 487                                                                               18.962                                                                             21.260                                                                             41.164                                                                             1.00                                                                              25.06            1DLC3594                    ATOM  3471                                                                              CB THR 487                                                                               18.183                                                                             19.760                                                                             43.728                                                                             1.00                                                                              25.40            1DLC3595                    ATOM  3472                                                                              CG1                                                                               THR 487                                                                               17.344                                                                             19.141                                                                             44.707                                                                             1.00                                                                              26.03            1DLC3596                    ATOM  3473                                                                              CG2                                                                               THR 487                                                                               19.320                                                                             20.487                                                                             44.438                                                                             1.00                                                                              26.87            1DLC3597                    ATOM  3474                                                                              N  ILE 488                                                                               18.370                                                                             22.909                                                                             42.584                                                                             1.00                                                                              22.95            1DLC3598                    ATOM  3475                                                                              CA ILE 488                                                                               19.257                                                                             23.915                                                                             41.993                                                                             1.00                                                                              24.06            1DLC3599                    ATOM  3476                                                                              C  ILE 488                                                                               20.378                                                                             24.293                                                                             42.966                                                                             1.00                                                                              24.12            1DLC3600                    ATOM  3477                                                                              O  ILE 488                                                                               20.120                                                                             24.890                                                                             44.017                                                                             1.00                                                                              26.94            1DLC3601                    ATOM  3478                                                                              CB ILE 488                                                                               18.496                                                                             25.214                                                                             41.633                                                                             1.00                                                                              22.37            1DLC3602                    ATOM  3479                                                                              CG1                                                                               ILE 488                                                                               17.343                                                                             24.915                                                                             40.668                                                                             1.00                                                                              21.27            1DLC3603                    ATOM  3480                                                                              CG2                                                                               ILE 488                                                                               19.456                                                                             26.225                                                                             41.020                                                                             1.00                                                                              16.51            1DLC3604                    ATOM  3481                                                                              CD1                                                                               ILE 488                                                                               16.468                                                                             26.115                                                                             40.375                                                                             1.00                                                                              20.81            1DLC3605                    ATOM  3482                                                                              N  PRO 489                                                                               21.628                                                                             23.895                                                                             42.667                                                                             1.00                                                                              24.55            1DLC3606                    ATOM  3483                                                                              CA PRO 489                                                                               22.741                                                                             24.239                                                                             43.567                                                                             1.00                                                                              22.62            1DLC3607                    ATOM  3484                                                                              C  PRO 489                                                                               23.285                                                                             25.646                                                                             43.290                                                                             1.00                                                                              20.82            1DLC3608                    ATOM  3485                                                                              O  PRO 489                                                                               23.321                                                                             26.094                                                                             42.137                                                                             1.00                                                                              22.41            1DLC3609                    ATOM  3486                                                                              CB PRO 489                                                                               23.797                                                                             23.175                                                                             43.240                                                                             1.00                                                                              20.03            1DLC3610                    ATOM  3487                                                                              CG PRO 489                                                                               23.028                                                                             22.083                                                                             42.522                                                                             1.00                                                                              22.59            1DLC3611                    ATOM  3488                                                                              CD PRO 489                                                                               22.052                                                                             22.876                                                                             41.695                                                                             1.00                                                                              20.82            1DLC3612                    ATOM  3489                                                                              N  VAL 490                                                                               23.663                                                                             26.348                                                                             44.353                                                                             1.00                                                                              18.80            1DLC3613                    ATOM  3490                                                                              CA VAL 490                                                                               24.234                                                                             27.686                                                                             44.241                                                                             1.00                                                                              20.56            1DLC3614                    ATOM  3491                                                                              C  VAL 490                                                                               25.539                                                                             27.745                                                                             45.045                                                                             1.00                                                                              22.82            1DLC3615                    ATOM  3492                                                                              O  VAL 490                                                                               25.576                                                                             27.364                                                                             46.225                                                                             1.00                                                                              20.83            1DLC3616                    ATOM  3493                                                                              CB VAL 490                                                                               23.257                                                                             28.772                                                                             44.732                                                                             1.00                                                                              22.17            1DLC3617                    ATOM  3494                                                                              CG1                                                                               VAL 490                                                                               23.899                                                                             30.147                                                                             44.621                                                                             1.00                                                                              20.36            1DLC3618                    ATOM  3495                                                                              CG2                                                                               VAL 490                                                                               21.989                                                                             28.740                                                                             43.895                                                                             1.00                                                                              24.80            1DLC3619                    ATOM  3496                                                                              N  LEU 491                                                                               26.610                                                                             28.206                                                                             44.397                                                                             1.00                                                                              22.64            1DLC3620                    ATOM  3497                                                                              CA LEU 491                                                                               27.931                                                                             28.285                                                                             45.034                                                                             1.00                                                                              21.56            1DLC3621                    ATOM  3498                                                                              C  LEU 491                                                                               28.397                                                                             29.704                                                                             45.377                                                                             1.00                                                                              19.56            1DLC3622                    ATOM  3499                                                                              O  LEU 491                                                                               28.279                                                                             30.622                                                                             44.566                                                                             1.00                                                                              21.15            1DLC3623                    ATOM  3500                                                                              CB LEU 491                                                                               28.993                                                                             27.610                                                                             44.143                                                                             1.00                                                                              22.96            1DLC3624                    ATOM  3501                                                                              CG LEU 491                                                                               28.739                                                                             26.213                                                                             43.549                                                                             1.00                                                                              22.44            1DLC3625                    ATOM  3502                                                                              CD1                                                                               LEU 491                                                                               29.970                                                                             25.728                                                                             42.817                                                                             1.00                                                                              19.64            1DLC3626                    ATOM  3503                                                                              CD2                                                                               LEU 491                                                                               28.359                                                                             25.222                                                                             44.617                                                                             1.00                                                                              23.77            1DLC3627                    ATOM  3504                                                                              N  THR 492                                                                               28.926                                                                             29.867                                                                             46.584                                                                             1.00                                                                              17.65            1DLC3628                    ATOM  3505                                                                              CA THR 492                                                                               29.451                                                                             31.153                                                                             47.050                                                                             1.00                                                                              21.18            1DLC3629                    ATOM  3506                                                                              C  THR 492                                                                               30.987                                                                             31.103                                                                             47.093                                                                             1.00                                                                              24.42            1DLC3630                    ATOM  3507                                                                              O  THR 492                                                                               31.580                                                                             30.111                                                                             47.545                                                                             1.00                                                                              25.76            1DLC3631                    ATOM  3508                                                                              CB THR 492                                                                               28.927                                                                             31.503                                                                             48.451                                                                             1.00                                                                              20.37            1DLC3632                    ATOM  3509                                                                              OG1                                                                               THR 492                                                                               27.498                                                                             31.509                                                                             48.419                                                                             1.00                                                                              25.73            1DLC3633                    ATOM  3510                                                                              CG2                                                                               THR 492                                                                               29.421                                                                             32.881                                                                             48.898                                                                             1.00                                                                              16.18            1DLC3634                    ATOM  3511                                                                              N  TRP 493                                                                               31.622                                                                             32.184                                                                             46.638                                                                             1.00                                                                              23.37            1DLC3635                    ATOM  3512                                                                              CA TRP 493                                                                               33.081                                                                             32.278                                                                             46.582                                                                             1.00                                                                              20.05            1DLC3636                    ATOM  3513                                                                              C  TRP 493                                                                               33.650                                                                             33.491                                                                             47.311                                                                             1.00                                                                              19.63            1DLC3637                    ATOM  3514                                                                              O  TRP 493                                                                               32.953                                                                             34.468                                                                             47.561                                                                             1.00                                                                              20.47            1DLC3638                    ATOM  3515                                                                              CB TRP 493                                                                               33.546                                                                             32.333                                                                             45.123                                                                             1.00                                                                              16.78            1DLC3639                    ATOM  3516                                                                              CG TRP 493                                                                               32.986                                                                             31.242                                                                             44.273                                                                             1.00                                                                              20.23            1DLC3640                    ATOM  3517                                                                              CD1                                                                               TRP 493                                                                               31.692                                                                             31.113                                                                             43.852                                                                             1.00                                                                              19.07            1DLC3641                    ATOM  3518                                                                              CD2                                                                               TRP 493                                                                               33.699                                                                             30.128                                                                             43.723                                                                             1.00                                                                              22.53            1DLC3642                    ATOM  3519                                                                              NE1                                                                               TRP 493                                                                               31.555                                                                             29.991                                                                             43.075                                                                             1.00                                                                              19.83            1DLC3643                    ATOM  3520                                                                              CE2                                                                               TRP 493                                                                               32.770                                                                             29.367                                                                             42.975                                                                             1.00                                                                              22.55            1DLC3644                    ATOM  3521                                                                              CE3                                                                               TRP 493                                                                               35.033                                                                             29.699                                                                             43.785                                                                             1.00                                                                              24.17            1DLC3645                    ATOM  3522                                                                              CZ2                                                                               TRP 493                                                                               33.132                                                                             28.198                                                                             42.294                                                                             1.00                                                                              22.22            1DLC3646                    ATOM  3523                                                                              CZ3                                                                               TRP 493                                                                               35.394                                                                             28.536                                                                             43.107                                                                             1.00                                                                              21.82            1DLC3647                    ATOM  3524                                                                              CH2                                                                               TRP 493                                                                               34.443                                                                             27.800                                                                             42.372                                                                             1.00                                                                              23.98            1DLC3648                    ATOM  3525                                                                              N  THR 494                                                                               34.930                                                                             33.402                                                                             47.661                                                                             1.00                                                                              19.10            1DLC3649                    ATOM  3526                                                                              CA THR 494                                                                               35.643                                                                             34.488                                                                             48.323                                                                             1.00                                                                              15.75            1DLC3650                    ATOM  3527                                                                              C  THR 494                                                                               36.962                                                                             34.781                                                                             47.583                                                                             1.00                                                                              15.71            1DLC3651                    ATOM  3528                                                                              O  THR 494                                                                               37.497                                                                             33.923                                                                             46.885                                                                             1.00                                                                              15.53            1DLC3652                    ATOM  3529                                                                              CB THR 494                                                                               35.867                                                                             34.199                                                                             49.832                                                                             1.00                                                                              17.76            1DLC3653                    ATOM  3530                                                                              OG1                                                                               THR 494                                                                               36.483                                                                             32.913                                                                             50.007                                                                             1.00                                                                              18.92            1DLC3654                    ATOM  3531                                                                              CG2                                                                               THR 494                                                                               34.530                                                                             34.232                                                                             50.580                                                                             1.00                                                                              13.45            1DLC3655                    ATOM  3532                                                                              N  HIS 495                                                                               37.448                                                                             36.011                                                                             47.679                                                                             1.00                                                                              17.73            1DLC3656                    ATOM  3533                                                                              CA HIS 495                                                                               38.670                                                                             36.416                                                                             46.992                                                                             1.00                                                                              18.64            1DLC3657                    ATOM  3534                                                                              C  HIS 495                                                                               39.964                                                                             35.767                                                                             47.516                                                                             1.00                                                                              21.22            1DLC3658                    ATOM  3535                                                                              O  HIS 495                                                                               40.139                                                                             35.531                                                                             48.712                                                                             1.00                                                                              19.11            1DLC3659                    ATOM  3536                                                                              CB HIS 495                                                                               38.788                                                                             37.953                                                                             46.991                                                                             1.00                                                                              18.90            1DLC3660                    ATOM  3537                                                                              CG HIS 495                                                                               39.689                                                                             38.498                                                                             45.923                                                                             1.00                                                                              18.38            1DLC3661                    ATOM  3538                                                                              ND1                                                                               HIS 495                                                                               41.018                                                                             38.801                                                                             46.147                                                                             1.00                                                                              20.90            1DLC3662                    ATOM  3539                                                                              CD2                                                                               HIS 495                                                                               39.454                                                                             38.800                                                                             44.624                                                                             1.00                                                                              19.10            1DLC3663                    ATOM  3540                                                                              CE1                                                                               HIS 495                                                                               41.559                                                                             39.261                                                                             45.035                                                                             1.00                                                                              19.17            1DLC3664                    ATOM  3541                                                                              NE2                                                                               HIS 495                                                                               40.631                                                                             39.272                                                                             44.096                                                                             1.00                                                                              18.99            1DLC3665                    ATOM  3542                                                                              N  LYS 496                                                                               40.861                                                                             35.489                                                                             46.576                                                                             1.00                                                                              23.22            1DLC3666                    ATOM  3543                                                                              CA LYS 496                                                                               42.171                                                                             34.876                                                                             46.818                                                                             1.00                                                                              25.84            1DLC3667                    ATOM  3544                                                                              C  LYS 496                                                                               43.103                                                                             35.666                                                                             47.755                                                                             1.00                                                                              26.33            1DLC3668                    ATOM  3545                                                                              O  LYS 496                                                                               43.986                                                                             35.095                                                                             48.388                                                                             1.00                                                                              26.36            1DLC3669                    ATOM  3546                                                                              CB LYS 496                                                                               42.853                                                                             34.711                                                                             45.462                                                                             1.00                                                                              27.94            1DLC3670                    ATOM  3547                                                                              CG LYS 496                                                                               44.251                                                                             34.139                                                                             45.447                                                                             1.00                                                                              28.83            1DLC3671                    ATOM  3548                                                                              CD LYS 496                                                                               44.885                                                                             34.574                                                                             44.138                                                                             1.00                                                                              31.25            1DLC3672                    ATOM  3549                                                                              CE LYS 496                                                                               46.050                                                                             33.721                                                                             43.720                                                                             1.00                                                                              30.77            1DLC3673                    ATOM  3550                                                                              NZ LYS 496                                                                               46.516                                                                             34.187                                                                             42.380                                                                             1.00                                                                              37.65            1DLC3674                    ATOM  3551                                                                              N  SER 497                                                                               42.900                                                                             36.977                                                                             47.834                                                                             1.00                                                                              25.35            1DLC3675                    ATOM  3552                                                                              CA SER 497                                                                               43.741                                                                             37.838                                                                             48.660                                                                             1.00                                                                              22.15            1DLC3676                    ATOM  3553                                                                              C  SER 497                                                                               43.607                                                                             37.644                                                                             50.152                                                                             1.00                                                                              22.22            1DLC3677                    ATOM  3554                                                                              O  SER 497                                                                               44.460                                                                             38.105                                                                             50.904                                                                             1.00                                                                              25.41            1DLC3678                    ATOM  3555                                                                              CB SER 497                                                                               43.486                                                                             39.306                                                                             48.342                                                                             1.00                                                                              23.23            1DLC3679                    ATOM  3556                                                                              OG SER 497                                                                               42.133                                                                             39.656                                                                             48.583                                                                             1.00                                                                              22.68            1DLC3680                    ATOM  3557                                                                              N  VAL 498                                                                               42.526                                                                             37.002                                                                             50.585                                                                             1.00                                                                              23.61            1DLC3681                    ATOM  3558                                                                              CA VAL 498                                                                               42.293                                                                             36.777                                                                             52.013                                                                             1.00                                                                              20.99            1DLC3682                    ATOM  3559                                                                              C  VAL 498                                                                               43.379                                                                             35.909                                                                             52.659                                                                             1.00                                                                              21.85            1DLC3683                    ATOM  3560                                                                              O  VAL 498                                                                               43.637                                                                             34.783                                                                             52.229                                                                             1.00                                                                              23.91            1DLC3684                    ATOM  3561                                                                              CB VAL 498                                                                               40.877                                                                             36.180                                                                             52.285                                                                             1.00                                                                              21.37            1DLC3685                    ATOM  3562                                                                              CG1                                                                               VAL 498                                                                               40.688                                                                             35.932                                                                             53.777                                                                             1.00                                                                              21.12            1DLC3686                    ATOM  3563                                                                              CG2                                                                               VAL 498                                                                               39.788                                                                             37.139                                                                             51.787                                                                             1.00                                                                              17.66            1DLC3687                    ATOM  3564                                                                              N  ASP 499                                                                               44.029                                                                             36.467                                                                             53.675                                                                             1.00                                                                              19.96            1DLC3688                    ATOM  3565                                                                              CA ASP 499                                                                               45.101                                                                             35.801                                                                             54.408                                                                             1.00                                                                              16.56            1DLC3689                    ATOM  3566                                                                              C  ASP 499                                                                               44.551                                                                             35.050                                                                             55.623                                                                             1.00                                                                              17.05            1DLC3690                    ATOM  3567                                                                              O  ASP 499                                                                               44.184                                                                             35.659                                                                             56.619                                                                             1.00                                                                              17.65            1DLC3691                    ATOM  3568                                                                              CB ASP 499                                                                               46.145                                                                             36.853                                                                             54.834                                                                             1.00                                                                              18.86            1DLC3692                    ATOM  3569                                                                              CG ASP 499                                                                               47.238                                                                             36.290                                                                             55.750                                                                             1.00                                                                              20.23            1DLC3693                    ATOM  3570                                                                              OD1                                                                               ASP 499                                                                               47.451                                                                             35.066                                                                             55.786                                                                             1.00                                                                              28.20            1DLC3694                    ATOM  3571                                                                              OD2                                                                               ASP 499                                                                               47.903                                                                             37.079                                                                             56.440                                                                             1.00                                                                              20.77            1DLC3695                    ATOM  3572                                                                              N  PHE 500                                                                               44.555                                                                             33.724                                                                             55.561                                                                             1.00                                                                              18.66            1DLC3696                    ATOM  3573                                                                              CA PHE 500                                                                               44.049                                                                             32.924                                                                             56.668                                                                             1.00                                                                              21.20            1DLC3697                    ATOM  3574                                                                              C  PHE 500                                                                               44.725                                                                             33.213                                                                             57.994                                                                             1.00                                                                              21.18            1DLC3698                    ATOM  3575                                                                              O  PHE 500                                                                               44.083                                                                             33.205                                                                             59.039                                                                             1.00                                                                              23.89            1DLC3699                    ATOM  3576                                                                              CB PHE 500                                                                               44.167                                                                             31.416                                                                             56.391                                                                             1.00                                                                              24.40            1DLC3700                    ATOM  3577                                                                              CG PHE 500                                                                               43.787                                                                             30.552                                                                             57.587                                                                             1.00                                                                              27.73            1DLC3701                    ATOM  3578                                                                              CD1                                                                               PHE 500                                                                               42.445                                                                             30.306                                                                             57.890                                                                             1.00                                                                              27.36            1DLC3702                    ATOM  3579                                                                              CD2                                                                               PHE 500                                                                               44.768                                                                             30.044                                                                             58.445                                                                             1.00                                                                              26.00            1DLC3703                    ATOM  3580                                                                              CE1                                                                               PHE 500                                                                               42.084                                                                             29.578                                                                             59.026                                                                             1.00                                                                              25.15            1DLC3704                    ATOM  3581                                                                              CE2                                                                               PHE 500                                                                               44.417                                                                             29.316                                                                             59.583                                                                             1.00                                                                              26.25            1DLC3705                    ATOM  3582                                                                              CZ PHE 500                                                                               43.070                                                                             29.084                                                                             59.874                                                                             1.00                                                                              25.99            1DLC3706                    ATOM  3583                                                                              N  PHE 501                                                                               46.027                                                                             33.443                                                                             57.959                                                                             1.00                                                                              21.02            1DLC3707                    ATOM  3584                                                                              CA PHE 501                                                                               46.767                                                                             33.685                                                                             59.191                                                                             1.00                                                                              21.95            1DLC3708                    ATOM  3585                                                                              C  PHE 501                                                                               46.673                                                                             35.047                                                                             59.877                                                                             1.00                                                                              20.32            1DLC3709                    ATOM  3586                                                                              O  PHE 501                                                                               47.173                                                                             35.189                                                                             60.986                                                                             1.00                                                                              20.00            1DLC3710                    ATOM  3587                                                                              CB PHE 501                                                                               48.234                                                                             33.285                                                                             59.001                                                                             1.00                                                                              25.51            1DLC3711                    ATOM  3588                                                                              CG PHE 501                                                                               48.419                                                                             31.823                                                                             58.707                                                                             1.00                                                                              24.22            1DLC3712                    ATOM  3589                                                                              CD1                                                                               PHE 501                                                                               48.383                                                                             30.887                                                                             59.733                                                                             1.00                                                                              24.19            1DLC3713                    ATOM  3590                                                                              CD2                                                                               PHE 501                                                                               48.589                                                                             31.380                                                                             57.403                                                                             1.00                                                                              25.81            1DLC3714                    ATOM  3591                                                                              CE1                                                                               PHE 501                                                                               48.510                                                                             29.536                                                                             59.467                                                                             1.00                                                                              23.35            1DLC3715                    ATOM  3592                                                                              CE2                                                                               PHE 501                                                                               48.717                                                                             30.027                                                                             57.125                                                                             1.00                                                                              24.04            1DLC3716                    ATOM  3593                                                                              CZ PHE 501                                                                               48.677                                                                             29.104                                                                             58.160                                                                             1.00                                                                              23.29            1DLC3717                    ATOM  3594                                                                              N  ASN 502                                                                               46.005                                                                             36.024                                                                             59.256                                                                             1.00                                                                              21.94            1DLC3718                    ATOM  3595                                                                              CA ASN 502                                                                               45.881                                                                             37.378                                                                             59.828                                                                             1.00                                                                              18.99            1DLC3719                    ATOM  3596                                                                              C  ASN 502                                                                               47.281                                                                             37.834                                                                             60.228                                                                             1.00                                                                              19.72            1DLC3720                    ATOM  3597                                                                              O  ASN 502                                                                               47.530                                                                             38.238                                                                             61.359                                                                             1.00                                                                              21.21            1DLC3721                    ATOM  3598                                                                              CB ASN 502                                                                               44.959                                                                             37.375                                                                             61.061                                                                             1.00                                                                              19.98            1DLC3722                    ATOM  3599                                                                              CG ASN 502                                                                               43.470                                                                             37.293                                                                             60.703                                                                             1.00                                                                              18.11            1DLC3723                    ATOM  3600                                                                              OD1                                                                               ASN 502                                                                               43.079                                                                             37.424                                                                             59.544                                                                             1.00                                                                              14.73            1DLC3724                    ATOM  3601                                                                              ND2                                                                               ASN 502                                                                               42.639                                                                             37.089                                                                             61.712                                                                             1.00                                                                              11.25            1DLC3725                    ATOM  3602                                                                              N  MET 503                                                                               48.197                                                                             37.741                                                                             59.278                                                                             1.00                                                                              22.71            1DLC3726                    ATOM  3603                                                                              CA MET 503                                                                               49.590                                                                             38.071                                                                             59.509                                                                             1.00                                                                              24.59            1DLC3727                    ATOM  3604                                                                              C  MET 503                                                                               49.958                                                                             39.5A4                                                                             59.415                                                                             1.00                                                                              26.15            1DLC3728                    ATOM  3605                                                                              O  MET 503                                                                               49.705                                                                             40.199                                                                             58.402                                                                             1.00                                                                              24.32            1DLC3729                    ATOM  3606                                                                              CB MET 503                                                                               50.456                                                                             37.245                                                                             58.565                                                                             1.00                                                                              31.72            1DLC3730                    ATOM  3607                                                                              CG MET 503                                                                               51.918                                                                             37.179                                                                             58.939                                                                             1.00                                                                              43.44            1DLC3731                    ATOM  3608                                                                              SD MET 503                                                                               52.748                                                                             35.901                                                                             57.973                                                                             1.00                                                                              55.24            1DLC3732                    ATOM  3609                                                                              CE MET 503                                                                               52.027                                                                             34.424                                                                             58.732                                                                             1.00                                                                              51.41            1DLC3733                    ATOM  3610                                                                              N  ILE 504                                                                               50.583                                                                             40.042                                                                             60.482                                                                             1.00                                                                              26.22            1DLC3734                    ATOM  3611                                                                              CA ILE 504                                                                               51.026                                                                             41.433                                                                             60.575                                                                             1.00                                                                              27.43            1DLC3735                    ATOM  3612                                                                              C  ILE 504                                                                               52.423                                                                             41.578                                                                             59.966                                                                             1.00                                                                              30.21            1DLC3736                    ATOM  3613                                                                              O  ILE 504                                                                               53.419                                                                             41.149                                                                             60.557                                                                             1.00                                                                              31.93            1DLC3737                    ATOM  3614                                                                              CB ILE 504                                                                               51.048                                                                             41.912                                                                             62.050                                                                             1.00                                                                              25.85            1DLC3738                    ATOM  3615                                                                              CG1                                                                               ILE 504                                                                               49.702                                                                             41.626                                                                             62.707                                                                             1.00                                                                              24.52            1DLC3739                    ATOM  3616                                                                              CG2                                                                               ILE 504                                                                               51.336                                                                             43.401                                                                             62.129                                                                             1.00                                                                              24.26            1DLC3740                    ATOM  3617                                                                              CD1                                                                               ILE 504                                                                               48.522                                                                             42.137                                                                             61.919                                                                             1.00                                                                              25.27            1DLC3741                    ATOM  3618                                                                              N  ASP 505                                                                               52.483                                                                             42.169                                                                             58.776                                                                             1.00                                                                              32.77            1DLC3742                    ATOM  3619                                                                              CA ASP 505                                                                               53.740                                                                             42.371                                                                             58.055                                                                             1.00                                                                              32.61            1DLC3743                    ATOM  3620                                                                              C  ASP 505                                                                               54.658                                                                             43.386                                                                             58.737                                                                             1.00                                                                              33.24            1DLC3744                    ATOM  3621                                                                              O  ASP 505                                                                               54.243                                                                             44.501                                                                             59.034                                                                             1.00                                                                              37.00            1DLC3745                    ATOM  3622                                                                              CB ASP 505                                                                               53.454                                                                             42.828                                                                             56.629                                                                             1.00                                                                              33.22            1DLC3746                    ATOM  3623                                                                              CG ASP 505                                                                               54.639                                                                             42.636                                                                             55.715                                                                             1.00                                                                              35.54            1DLC3747                    ATOM  3624                                                                              OD1                                                                               ASP 505                                                                               55.606                                                                             43.413                                                                             55.804                                                                             1.00                                                                              40.96            1DLC3748                    ATOM  3625                                                                              OD2                                                                               ASP 505                                                                               54.612                                                                             41.694                                                                             54.903                                                                             1.00                                                                              39.21            1DLC3749                    ATOM  3626                                                                              N  SER 506                                                                               55.924                                                                             43.018                                                                             58.910                                                                             1.00                                                                              33.99            1DLC3750                    ATOM  3627                                                                              CA SER 506                                                                               56.916                                                                             43.878                                                                             59.569                                                                             1.00                                                                              31.14            1DLC3751                    ATOM  3628                                                                              C  SER 506                                                                               57.433                                                                             45.058                                                                             58.753                                                                             1.00                                                                              26.45            1DLC3752                    ATOM  3629                                                                              O  SER 506                                                                               58.091                                                                             45.932                                                                             59.296                                                                             1.00                                                                              25.94            1DLC3753                    ATOM  3630                                                                              CB SER 506                                                                               58.116                                                                             43.049                                                                             60.035                                                                             1.00                                                                              35.65            1DLC3754                    ATOM  3631                                                                              OG SER 506                                                                               58.691                                                                             42.318                                                                             58.955                                                                             1.00                                                                              38.49            1DLC3755                    ATOM  3632                                                                              N  LYS 507                                                                               57.181                                                                             45.064                                                                             57.452                                                                             1.00                                                                              24.25            1DLC3756                    ATOM  3633                                                                              CA LYS 507                                                                               57.653                                                                             46.155                                                                             56.603                                                                             1.00                                                                              29.55            1DLC3757                    ATOM  3634                                                                              C  LYS 507                                                                               56.540                                                                             47.011                                                                             56.016                                                                             1.00                                                                              29.60            1DLC3758                    ATOM  3635                                                                              O  LYS 507                                                                               56.773                                                                             48.150                                                                             55.611                                                                             1.00                                                                              30.94            1DLC3759                    ATOM  3636                                                                              CB LYS 507                                                                               58.494                                                                             45.630                                                                             55.435                                                                             1.00                                                                              34.60            1DLC3760                    ATOM  3637                                                                              CG LYS 507                                                                               59.661                                                                             44.732                                                                             55.793                                                                             1.00                                                                              44.16            1DLC3761                    ATOM  3638                                                                              CD LYS 507                                                                               59.206                                                                             43.295                                                                             56.004                                                                             1.00                                                                              54.27            1DLC3762                    ATOM  3639                                                                              CE LYS 507                                                                               60.303                                                                             42.327                                                                             55.603                                                                             1.00                                                                              60.68            1DLC3763                    ATOM  3640                                                                              NZ LYS 507                                                                               60.686                                                                             42.532                                                                             54.163                                                                             1.00                                                                              64.19            1DLC3764                    ATOM  3641                                                                              N  LYS 508                                                                               55.339                                                                             46.452                                                                             55.942                                                                             1.00                                                                              28.18            1DLC3765                    ATOM  3642                                                                              CA LYS 508                                                                               54.204                                                                             47.165                                                                             55.364                                                                             1.00                                                                              24.79            1DLC3766                    ATOM  3643                                                                              C  LYS 508                                                                               53.175                                                                             47.608                                                                             56.378                                                                             1.00                                                                              23.56            1DLC3767                    ATOM  3644                                                                              O  LYS 508                                                                               53.248                                                                             47.273                                                                             57.563                                                                             1.00                                                                              25.61            1DLC3768                    ATOM  3645                                                                              CB LYS 508                                                                               53.480                                                                             46.273                                                                             54.359                                                                             1.00                                                                              21.88            1DLC3769                    ATOM  3646                                                                              CG LYS 508                                                                               54.329                                                                             45.804                                                                             53.233                                                                             1.00                                                                              25.15            1DLC3770                    ATOM  3647                                                                              CD LYS 508                                                                               53.592                                                                             44.816                                                                             52.383                                                                             1.00                                                                              26.67            1DLC3771                    ATOM  3648                                                                              CE LYS 508                                                                               54.495                                                                             44.343                                                                             51.263                                                                             1.00                                                                              31.83            1DLC3772                    ATOM  3649                                                                              NZ LYS 508                                                                               53.858                                                                             43.338                                                                             50.378                                                                             1.00                                                                              35.43            1DLC3773                    ATOM  3650                                                                              N  ILE 509                                                                               52.239                                                                             48.413                                                                             55.900                                                                             1.00                                                                              20.93            1DLC3774                    ATOM  3651                                                                              CA ILE 509                                                                               51.121                                                                             48.837                                                                             56.715                                                                             1.00                                                                              18.88            1DLC3775                    ATOM  3652                                                                              C  ILE 509                                                                               50.137                                                                             47.695                                                                             56.446                                                                             1.00                                                                              19.04            1DLC3776                    ATOM  3653                                                                              O  ILE 509                                                                               49.887                                                                             47.333                                                                             55.293                                                                             1.00                                                                              17.01            1DLC3777                    ATOM  3654                                                                              CB ILE 509                                                                               50.539                                                                             50.186                                                                             56.236                                                                             1.00                                                                              18.64            1DLC3778                    ATOM  3655                                                                              CG1                                                                               ILE 509                                                                               51.530                                                                             51.317                                                                             56.558                                                                             1.00                                                                              14.90            1DLC3779                    ATOM  3656                                                                              CG2                                                                               ILE 509                                                                               49.157                                                                             50.421                                                                             56.872                                                                             1.00                                                                              15.43            1DLC3780                    ATOM  3657                                                                              CD1                                                                               ILE 509                                                                               51.149                                                                             52.677                                                                             56.007                                                                             1.00                                                                              11.51            1DLC3781                    ATOM  3658                                                                              N  THR 510                                                                               49.674                                                                             47.052                                                                             57.506                                                                             1.00                                                                              21.46            1DLC3782                    ATOM  3659                                                                              CA THR 510                                                                               48.751                                                                             45.931                                                                             57.358                                                                             1.00                                                                              20.67            1DLC3783                    ATOM  3660                                                                              C  THR 510                                                                               47.309                                                                             46.291                                                                             57.709                                                                             1.00                                                                              19.90            1DLC3784                    ATOM  3661                                                                              O  THR 510                                                                               47.034                                                                             46.781                                                                             58.806                                                                             1.00                                                                              23.72            1DLC3785                    ATOM  3662                                                                              CB THR 510                                                                               49.181                                                                             44.726                                                                             58.253                                                                             1.00                                                                              20.85            1DLC3786                    ATOM  3663                                                                              OG1                                                                               THR 510                                                                               50.522                                                                             44.326                                                                             57.929                                                                             1.00                                                                              20.93            1DLC3787                    ATOM  3664                                                                              CG2                                                                               THR 510                                                                               48.241                                                                             43.541                                                                             58.051                                                                             1.00                                                                              21.70            1DLC3788                    ATOM  3665                                                                              N  GLN 511                                                                               46.399                                                                             46.087                                                                             56.763                                                                             1.00                                                                              18.34            1DLC3789                    ATOM  3666                                                                              CA GLN 511                                                                               44.979                                                                             46.336                                                                             57.001                                                                             1.00                                                                              16.87            1DLC3790                    ATOM  3667                                                                              C  GLN 511                                                                               44.283                                                                             45.037                                                                             57.428                                                                             1.00                                                                              20.95            1DLC3791                    ATOM  3668                                                                              O  GLN 511                                                                               44.281                                                                             44.048                                                                             56.689                                                                             1.00                                                                              22.60            1DLC3792                    ATOM  3669                                                                              CB GLN 511                                                                               44.293                                                                             46.868                                                                             55.748                                                                             1.00                                                                              12.52            1DLC3793                    ATOM  3670                                                                              CG GLN 511                                                                               44.506                                                                             48.332                                                                             55.481                                                                             1.00                                                                              14.00            1DLC3794                    ATOM  3671                                                                              CD GLN 511                                                                               43.533                                                                             48.867                                                                             54.440                                                                             1.00                                                                              18.99            1DLC3795                    ATOM  3672                                                                              OE1                                                                               GLN 511                                                                               43.290                                                                             48.236                                                                             53.417                                                                             1.00                                                                              21.33            1DLC3796                    ATOM  3673                                                                              NE2                                                                               GLN 511                                                                               42.956                                                                             50.018                                                                             54.708                                                                             1.00                                                                              19.00            1DLC3797                    ATOM  3674                                                                              N  LEU 512                                                                               43.710                                                                             45.043                                                                             58.626                                                                             1.00                                                                              22.52            1DLC3798                    ATOM  3675                                                                              CA LEU 512                                                                               42.989                                                                             43.889                                                                             59.162                                                                             1.00                                                                              21.75            1DLC3799                    ATOM  3676                                                                              C  LEU 512                                                                               41.480                                                                             44.130                                                                             59.277                                                                             1.00                                                                              19.63            1DLC3800                    ATOM  3677                                                                              O  LEU 512                                                                               41.023                                                                             44.839                                                                             60.175                                                                             1.00                                                                              19.45            1DLC3801                    ATOM  3678                                                                              CB LEU 512                                                                               43.522                                                                             43.518                                                                             60.546                                                                             1.00                                                                              25.44            1DLC3802                    ATOM  3679                                                                              CG LEU 512                                                                               44.431                                                                             42.303                                                                             60.672                                                                             1.00                                                                              32.43            1DLC3803                    ATOM  3680                                                                              CD1                                                                               LEU 512                                                                               44.559                                                                             41.951                                                                             62.148                                                                             1.00                                                                              32.49            1DLC3804                    ATOM  3681                                                                              CD2                                                                               LEU 512                                                                               43.843                                                                             41.128                                                                             59.892                                                                             1.00                                                                              35.48            1DLC3805                    ATOM  3682                                                                              N  PRO 513                                                                               40.685                                                                             43.537                                                                             58.372                                                                             1.00                                                                              17.33            1DLC3806                    ATOM  3683                                                                              CA PRO 513                                                                               39.227                                                                             43.700                                                                             58.402                                                                             1.00                                                                              16.04            1DLC3807                    ATOM  3684                                                                              C  PRO 513                                                                               38.669                                                                             43.052                                                                             59.662                                                                             1.00                                                                              15.65            1DLC3808                    ATOM  3685                                                                              O  PRO 513                                                                               39.043                                                                             41.933                                                                             59.993                                                                             1.00                                                                              19.58            1DLC3809                    ATOM  3686                                                                              CB PRO 513                                                                               38.776                                                                             42.934                                                                             57.163                                                                             1.00                                                                              12.95            1DLC3810                    ATOM  3687                                                                              CG PRO 513                                                                               39.964                                                                             43.01T                                                                             56.253                                                                             1.00                                                                              16.06            1DLC3811                    ATOM  3688                                                                              CD PRO 513                                                                               41.096                                                                             42.757                                                                             57.195                                                                             1.00                                                                              16.99            1DLC3812                    ATOM  3689                                                                              N  LEU 514                                                                               37.775                                                                             43.742                                                                             60.361                                                                             1.00                                                                              17.11            IDLC3813                    ATOM  3690                                                                              CA LEU 514                                                                               37.187                                                                             43.195                                                                             61.584                                                                             1.00                                                                              17.00            1DLC3814                    ATOM  3691                                                                              C  LEU 514                                                                               36.391                                                                             41.896                                                                             61.390                                                                             1.00                                                                              16.47            1DLC3815                    ATOM  3692                                                                              O  LEU 514                                                                               36.222                                                                             41.115                                                                             62.334                                                                             1.00                                                                              15.86            1DLC3816                    ATOM  3693                                                                              CB LEU 514                                                                               36.324                                                                             44.249                                                                             62.279                                                                             1.00                                                                              20.38            1DLC3817                    ATOM  3694                                                                              CG LEU 514                                                                               36.962                                                                             44.901                                                                             63.512                                                                             1.00                                                                              24.64            1DLC3818                    ATOM  3695                                                                              CD1                                                                               LEU 514                                                                               37.104                                                                             43.877                                                                             64.633                                                                             1.00                                                                              22.36            1DLC3819                    ATOM  3696                                                                              CD2                                                                               LEU 514                                                                               38.319                                                                             45.500                                                                             63.156                                                                             1.00                                                                              26.24            1DLC3820                    ATOM  3697                                                                              N  VAL 515                                                                               35.888                                                                             41.668                                                                             60.179                                                                             1.00                                                                              13.44            1DLC3821                    ATOM  3698                                                                              CA VAL 515                                                                               35.147                                                                             40.443                                                                             59.906                                                                             1.00                                                                              17.69            1DLC3822                    ATOM  3699                                                                              C  VAL 515                                                                               36.038                                                                             39.200                                                                             59.983                                                                             1.00                                                                              19.77            1DLC3823                    ATOM  3700                                                                              O  VAL 515                                                                               35.541                                                                             38.082                                                                             59.927                                                                             1.00                                                                              21.83            1DLC3824                    ATOM  3701                                                                              CB VAL 515                                                                               34.382                                                                             40.476                                                                             58.546                                                                             1.00                                                                              15.76            1DLC3825                    ATOM  3702                                                                              CG1                                                                               VAL 515                                                                               33.316                                                                             41.552                                                                             58.584                                                                             1.00                                                                              15.76            1DLC3826                    ATOM  3703                                                                              CG2                                                                               VAL 515                                                                               35.326                                                                             40.693                                                                             57.386                                                                             1.00                                                                              13.28            1DLC3827                    ATOM  3704                                                                              N  LYS 516                                                                               37.351                                                                             39.405                                                                             60.106                                                                             1.00                                                                              22.24            1DLC3828                    ATOM  3705                                                                              CA LYS 516                                                                               38.311                                                                             38.304                                                                             60.233                                                                             1.00                                                                              20.87            1DLC3829                    ATOM  3706                                                                              C  LYS 516                                                                               38.405                                                                             37.867                                                                             61.704                                                                             1.00                                                                              21.16            1DLC3830                    ATOM  3707                                                                              O  LYS 516                                                                               39.164                                                                             36.967                                                                             62.059                                                                             1.00                                                                              22.50            1DLC3831                    ATOM  3708                                                                              CB LYS 516                                                                               39.692                                                                             38.716                                                                             59.717                                                                             1.00                                                                              19.84            1DLC3832                    ATOM  3709                                                                              CG LYS 516                                                                               39.768                                                                             39.001                                                                             58.211                                                                             1.00                                                                              19.10            1DLC3833                    ATOM  3710                                                                              CD LYS 516                                                                               39.499                                                                             37.756                                                                             57.361                                                                             1.00                                                                              18.48            1DLC3834                    ATOM  3711                                                                              CE LYS 516                                                                               40.581                                                                             36.692                                                                             57.519                                                                             1.00                                                                              19.98            1DLC3835                    ATOM  3712                                                                              NZ LYS 516                                                                               41.938                                                                             37.189                                                                             57.136                                                                             1.00                                                                              18.44            1DLC3836                    ATOM  3713                                                                              N  ALA 517                                                                               37.652                                                                             38.534                                                                             62.568                                                                             1.00                                                                              19.22            1DLC3837                    ATOM  3714                                                                              CA ALA 517                                                                               37.631                                                                             38.173                                                                             63.972                                                                             1.00                                                                              18.13            1DLC3838                    ATOM  3715                                                                              C  ALA 517                                                                               37.037                                                                             36.769                                                                             64.075                                                                             1.00                                                                              18.92            1DLC3839                    ATOM  3716                                                                              O  ALA 517                                                                               36.396                                                                             36.277                                                                             63.141                                                                             1.00                                                                              21.52            1DLC3840                    ATOM  3717                                                                              CB ALA 517                                                                               36.782                                                                             39.171                                                                             64.759                                                                             1.00                                                                              12.71            1DLC3841                    ATOM  3718                                                                              N  TYR 518                                                                               37.289                                                                             36.093                                                                             65.183                                                                             1.00                                                                              21.01            1DLC3842                    ATOM  3719                                                                              CA TYR 518                                                                               36.728                                                                             34.759                                                                             65.364                                                                             1.00                                                                              23.07            1DLC3843                    ATOM  3720                                                                              C  TYR 518                                                                               35.657                                                                             34.785                                                                             66.451                                                                             1.00                                                                              24.25            1DLC3844                    ATOM  3721                                                                              O  TYR 518                                                                               34.881                                                                             33.846                                                                             66.592                                                                             1.00                                                                              28.06            1DLC3845                    ATOM  3722                                                                              CB TYR 518                                                                               37.824                                                                             33.743                                                                             65.716                                                                             1.00                                                                              19.73            1DLC3846                    ATOM  3723                                                                              CG TYR 518                                                                               38.472                                                                             33.952                                                                             67.065                                                                             1.00                                                                              19.33            1DLC3847                    ATOM  3724                                                                              CD1                                                                               TYR 518                                                                               37.888                                                                             33.442                                                                             68.229                                                                             1.00                                                                              22.01            1DLC3848                    ATOM  3725                                                                              CD2                                                                               TYR 518                                                                               39.676                                                                             34.644                                                                             67.180                                                                             1.00                                                                              19.86            1DLC3849                    ATOM  3726                                                                              CE1                                                                               TYR 518                                                                               38.485                                                                             33.611                                                                             69.471                                                                             1.00                                                                              18.79            1DLC3850                    ATOM  3727                                                                              CE2                                                                               TYR 518                                                                               40.283                                                                             34.823                                                                             68.417                                                                             1.00                                                                              20.61            1DLC3851                    ATOM  3728                                                                              CZ TYR 518                                                                               39.682                                                                             34.304                                                                             69.557                                                                             1.00                                                                              22.78            1DLC3852                    ATOM  3729                                                                              OH TYR 518                                                                               40.270                                                                             34.493                                                                             70.783                                                                             1.00                                                                              24.17            1DLC3853                    ATOM  3730                                                                              N  LYS 519                                                                               35.564                                                                             35.905                                                                             67.160                                                                             1.00                                                                              24.18            1DLC3854                    ATOM  3731                                                                              CA LYS 519                                                                               34.615                                                                             36.027                                                                             68.249                                                                             1.00                                                                              21.87            1DLC3855                    ATOM  3732                                                                              C  LYS 519                                                                               34.027                                                                             37.429                                                                             68.430                                                                             1.00                                                                              22.52            1DLC3856                    ATOM  3733                                                                              O  LYS 519                                                                               34.758                                                                             38.410                                                                             68.527                                                                             1.00                                                                              22.87            1DLC3857                    ATOM  3734                                                                              CB LYS 519                                                                               35.328                                                                             35.593                                                                             69.526                                                                             1.00                                                                              24.86            1DLC3858                    ATOM  3735                                                                              CG LYS 519                                                                               34.512                                                                             35.599                                                                             70.783                                                                             1.00                                                                              31.39            1DLC3859                    ATOM  3736                                                                              CD LYS 519                                                                               35.400                                                                             35.210                                                                             71.953                                                                             1.00                                                                              38.43            1DLC3860                    ATOM  3737                                                                              CE LYS 519                                                                               34.616                                                                             35.118                                                                             73.255                                                                             1.00                                                                              45.64            1DLC3861                    ATOM  3738                                                                              NZ LYS 519                                                                               35.523                                                                             34.808                                                                             74.400                                                                             1.00                                                                              49.23            1DLC3862                    ATOM  3739                                                                              N  LEU 520                                                                               32.703                                                                             37.522                                                                             68.422                                                                             1.00                                                                              21.94            1DLC3863                    ATOM  3740                                                                              CA LEU 520                                                                               32.024                                                                             38.794                                                                             68.653                                                                             1.00                                                                              24.06            1DLC3864                    ATOM  3741                                                                              C  LEU 520                                                                               31.408                                                                             38.738                                                                             70.050                                                                             1.00                                                                              27.63            1DLC3865                    ATOM  3742                                                                              O  LEU 520                                                                               31.091                                                                             37.660                                                                             70.556                                                                             1.00                                                                              29.95            1DLC3866                    ATOM  3743                                                                              CB LEU 520                                                                               30.943                                                                             39.063                                                                             67.600                                                                             1.00                                                                              20.93            1DLC3867                    ATOM  3744                                                                              CG LEU 520                                                                               31.438                                                                             39.461                                                                             66.209                                                                             1.00                                                                              21.24            1DLC3868                    ATOM  3745                                                                              CD1                                                                               LEU 520                                                                               30.268                                                                             39.640                                                                             65.274                                                                             1.00                                                                              21.64            1DLC3869                    ATOM  3746                                                                              CD2                                                                               LEU 520                                                                               32.252                                                                             40.744                                                                             66.292                                                                             1.00                                                                              20.28            1DLC3870                    ATOM  3747                                                                              N  GLN 521                                                                               31.214                                                                             39.894                                                                             70.668                                                                             1.00                                                                              30.71            1DLC3871                    ATOM  3748                                                                              CA GLN 521                                                                               30.667                                                                             39.935                                                                             72.015                                                                             1.00                                                                              32.68            1DLC3872                    ATOM  3749                                                                              C  GLN 521                                                                               29.943                                                                             41.237                                                                             72.338                                                                             1.00                                                                              32.85            1DLC3873                    ATOM  3750                                                                              O  GLN 521                                                                               29.963                                                                             42.183                                                                             71.554                                                                             1.00                                                                              33.06            1DLC3874                    ATOM  3751                                                                              CB GLN 521                                                                               31.795                                                                             39.681                                                                             73.019                                                                             1.00                                                                              38.17            1DLC3875                    ATOM  3752                                                                              CG GLN 521                                                                               33.040                                                                             40.525                                                                             72.764                                                                             1.00                                                                              47.16            1DLC3876                    ATOM  3753                                                                              CD GLN 521                                                                               34.341                                                                             39.733                                                                             72.860                                                                             1.00                                                                              50.53            1DLC3877                    ATOM  3754                                                                              OE1                                                                               GLN 521                                                                               34.416                                                                             38.715                                                                             73.546                                                                             1.00                                                                              53.19            1DLC3878                    ATOM  3755                                                                              NE2                                                                               GLN 521                                                                               35.372                                                                             40.205                                                                             72.171                                                                             1.00                                                                              49.13            1DLC3879                    ATOM  3756                                                                              N  SER 522                                                                               29.284                                                                             41.261                                                                             73.494                                                                             1.00                                                                              34.02            1DLC3880                    ATOM  3757                                                                              CA SER 522                                                                               28.529                                                                             42.427                                                                             73.963                                                                             1.00                                                                              33.25            1DLC3881                    ATOM  3758                                                                              C  SER 522                                                                               27.458                                                                             42.871                                                                             72.973                                                                             1.00                                                                              32.49            1DLC3882                    ATOM  3759                                                                              O  SER 522                                                                               27.132                                                                             44.051                                                                             72.887                                                                             1.00                                                                              34.90            1DLC3883                    ATOM  3760                                                                              CB SER 522                                                                               29.464                                                                             43.607                                                                             74.267                                                                             1.00                                                                              34.44            1DLC3884                    ATOM  3761                                                                              OG SER 522                                                                               30.460                                                                             43.269                                                                             75.221                                                                             1.00                                                                              37.23            1DLC3885                    ATOM  3762                                                                              N  GLY 523                                                                               26.932                                                                             41.931                                                                             72.201                                                                             1.00                                                                              32.83            1DLC3886                    ATOM  3763                                                                              CA GLY 523                                                                               25.906                                                                             42.283                                                                             71.236                                                                             1.00                                                                              35.47            1DLC3887                    ATOM  3764                                                                              C  GLY 523                                                                               26.415                                                                             42.914                                                                             69.946                                                                             1.00                                                                              37.76            1DLC3888                    ATOM  3765                                                                              O  GLY 523                                                                               25.694                                                                             43.676                                                                             69.291                                                                             1.00                                                                              43.56            1DLC3889                    ATOM  3766                                                                              N  ALA 524                                                                               27.675                                                                             42.662                                                                             69.606                                                                             1.00                                                                              33.37            1DLC3890                    ATOM  3767                                                                              CA ALA 524                                                                               28.228                                                                             43.181                                                                             68.366                                                                             1.00                                                                              25.62            1DLC3891                    ATOM  3768                                                                              C  ALA 524                                                                               27.772                                                                             42.233                                                                             67.254                                                                             1.00                                                                              25.43            1DLC3892                    ATOM  3769                                                                              O  ALA 524                                                                               27.507                                                                             41.054                                                                             67.501                                                                             1.00                                                                              25.41            1DLC3893                    ATOM  3770                                                                              CB ALA 524                                                                               29.742                                                                             43.232                                                                             68.443                                                                             1.00                                                                              22.42            1DLC3894                    ATOM  3771                                                                              N  SER 525                                                                               27.648                                                                             42.738                                                                             66.035                                                                             1.00                                                                              24.40            1DLC3895                    ATOM  3772                                                                              CA SER 525                                                                               27.224                                                                             41.887                                                                             64.927                                                                             1.00                                                                              22.01            1DLC3896                    ATOM  3773                                                                              C  SER 525                                                                               27.755                                                                             42.326                                                                             63.571                                                                             1.00                                                                              19.44            1DLC3897                    ATOM  3774                                                                              O  SER 525                                                                               28.125                                                                             43.479                                                                             63.380                                                                             1.00                                                                              21.43            1DLC3898                    ATOM  3775                                                                              CB SER 525                                                                               25.702                                                                             41.820                                                                             64.863                                                                             1.00                                                                              21.54            1DLC3899                    ATOM  3776                                                                              OG SER 525                                                                               25.147                                                                             43.092                                                                             64.593                                                                             1.00                                                                              25.37            1DLC3900                    ATOM  3777                                                                              N  VAL 526                                                                               27.797                                                                             41.387                                                                             62.634                                                                             1.00                                                                              19.65            1DLC3901                    ATOM  3778                                                                              CA VAL 526                                                                               28.261                                                                             41.669                                                                             61.282                                                                             1.00                                                                              16.70            1DLC3902                    ATOM  3779                                                                              C  VAL 526                                                                               27.096                                                                             42.274                                                                             60.519                                                                             1.00                                                                              19.66            1DLC3903                    ATOM  3780                                                                              O  VAL 526                                                                               25.986                                                                             41.742                                                                             60.522                                                                             1.00                                                                              25.06            1DLC3904                    ATOM  3781                                                                              CB VAL 526                                                                               28.753                                                                             40.403                                                                             60.562                                                                             1.00                                                                              14.06            1DLC3905                    ATOM  3782                                                                              CG1                                                                               VAL 526                                                                               29.368                                                                             40.763                                                                             59.211                                                                             1.00                                                                              11.22            1DLC3906                    ATOM  3783                                                                              CG2                                                                               VAL 526                                                                               29.761                                                                             39.676                                                                             61.436                                                                             1.00                                                                              14.41            1DLC3907                    ATOM  3784                                                                              N  VAL 527                                                                               27.365                                                                             43.390                                                                             59.863                                                                             1.00                                                                              19.37            1DLC3908                    ATOM  3785                                                                              CA VAL 527                                                                               26.361                                                                             44.119                                                                             59.116                                                                             1.00                                                                              15.54            1DLC3909                    ATOM  3786                                                                              C  VAL 527                                                                               26.834                                                                             44.303                                                                             57.672                                                                             1.00                                                                              15.70            1DLC3910                    ATOM  3787                                                                              O  VAL 527                                                                               28.034                                                                             44.247                                                                             57.392                                                                             1.00                                                                              17.61            1DLC3911                    ATOM  3788                                                                              CB VAL 527                                                                               26.098                                                                             45.469                                                                             59.854                                                                             1.00                                                                              17.86            1DLC3912                    ATOM  3789                                                                              CG1                                                                               VAL 527                                                                               25.762                                                                             46.576                                                                             58.907                                                                             1.00                                                                              23.79            1DLC3913                    ATOM  3790                                                                              CG2                                                                               VAL 527                                                                               24.983                                                                             45.294                                                                             60.864                                                                             1.00                                                                              15.07            1DLC3914                    ATOM  3791                                                                              N  ALA 528                                                                               25.887                                                                             44.454                                                                             56.751                                                                             1.00                                                                              14.37            1DLC3915                    ATOM  3792                                                                              CA ALA 528                                                                               26.204                                                                             A4.644                                                                             55.340                                                                             1.00                                                                              15.60            1DLC3916                    ATOM  3793                                                                              C  ALA 528                                                                               27.117                                                                             45.844                                                                             55.173                                                                             1.00                                                                              18.07            1DLC3917                    ATOM  3794                                                                              O  ALA 528                                                                               26.894                                                                             46.890                                                                             55.775                                                                             1.00                                                                              20.56            1DLC3918                    ATOM  3795                                                                              CB ALA 528                                                                               24.937                                                                             44.838                                                                             54.531                                                                             1.00                                                                              12.04            1DLC3919                    ATOM  3796                                                                              N  GLY 529                                                                               28.152                                                                             45.687                                                                             54.361                                                                             1.00                                                                              18.47            1DLC3920                    ATOM  3797                                                                              CA GLY 529                                                                               29.081                                                                             46.778                                                                             54.165                                                                             1.00                                                                              19.29            1DLC3921                    ATOM  3798                                                                              C  GLY 529                                                                               28.491                                                                             47.865                                                                             53.305                                                                             1.00                                                                              19.15            1DLC3922                    ATOM  3799                                                                              O  GLY 529                                                                               27.583                                                                             47.595                                                                             52.518                                                                             1.00                                                                              21.01            1DLC3923                    ATOM  3800                                                                              N  PRO 530                                                                               29.007                                                                             49.101                                                                             53.404                                                                             1.00                                                                              18.13            1DLC3924                    ATOM  3801                                                                              CA PRO 530                                                                               28.519                                                                             50.239                                                                             52.618                                                                             1.00                                                                              16.51            1DLC3925                    ATOM  3802                                                                              C  PRO 530                                                                               28.840                                                                             50.175                                                                             51.112                                                                             1.00                                                                              16.39            1DLC3926                    ATOM  3803                                                                              O  PRO 530                                                                               28.610                                                                             51.139                                                                             50.386                                                                             1.00                                                                              17.87            1DLC3927                    ATOM  3804                                                                              CB PRO 530                                                                               29.177                                                                             51.434                                                                             53.313                                                                             1.00                                                                              15.38            1DLC3928                    ATOM  3805                                                                              CG PRO 530                                                                               30.462                                                                             50.873                                                                             53.810                                                                             1.00                                                                              15.73            1DLC3929                    ATOM  3806                                                                              CD PRO 530                                                                               30.048                                                                             49.526                                                                             54.357                                                                             1.00                                                                              17.90            1DLC3930                    ATOM  3807                                                                              N  ARG 531                                                                               29.347                                                                             49.024                                                                             50.660                                                                             1.00                                                                              15.80            1DLC3931                    ATOM  3808                                                                              CA ARG 531                                                                               29.705                                                                             48.743                                                                             49.260                                                                             1.00                                                                              16.70            1DLC3932                    ATOM  3809                                                                              C  ARG 531                                                                               31.048                                                                             49.293                                                                             48.778                                                                             1.00                                                                              18.92            1DLC3933                    ATOM  3810                                                                              O  ARG 531                                                                               31.478                                                                             48.985                                                                             47.672                                                                             1.00                                                                              23.34            1DLC3934                    ATOM  3811                                                                              CB ARG 531                                                                               28.603                                                                             49.164                                                                             48.270                                                                             1.00                                                                              19.92            1DLC3935                    ATOM  3812                                                                              CG ARG 531                                                                               27.162                                                                             48.685                                                                             48.568                                                                             1.00                                                                              28.20            1DLC3936                    ATOM  3813                                                                              CD ARG 531                                                                               26.953                                                                             47.171                                                                             48.469                                                                             1.00                                                                              31.24            1DLC3937                    ATOM  3814                                                                              NE ARG 531                                                                               27.509                                                                             46.435                                                                             49.608                                                                             1.00                                                                              37.62            1DLC3938                    ATOM  3815                                                                              CZ ARG 531                                                                               26.844                                                                             45.526                                                                             50.321                                                                             1.00                                                                              41.22            1DLC3939                    ATOM  3816                                                                              NH1                                                                               ARG 531                                                                               25.586                                                                             45.229                                                                             50.024                                                                             1.00                                                                              43.68            1DLC3940                    ATOM  3817                                                                              NH2                                                                               ARG 531                                                                               27.438                                                                             44.914                                                                             51.342                                                                             1.00                                                                              43.63            1DLC3941                    ATOM  3818                                                                              N  PHE 532                                                                               31.724                                                                             50.094                                                                             49.593                                                                             1.00                                                                              19.98            1DLC3942                    ATOM  3819                                                                              CA PHE 532                                                                               33.014                                                                             50.644                                                                             49.175                                                                             1.00                                                                              18.86            1DLC3943                    ATOM  3820                                                                              C  PHE 532                                                                               34.203                                                                             50.235                                                                             50.042                                                                             1.00                                                                              18.66            1DLC3944                    ATOM  3821                                                                              O  PHE 532                                                                               35.295                                                                             50.766                                                                             49.876                                                                             1.00                                                                              22.14            1DLC3945                    ATOM  3822                                                                              CB PHE 532                                                                               32.947                                                                             52.174                                                                             49.060                                                                             1.00                                                                              16.92            1DLC3946                    ATOM  3823                                                                              CG PHE 532                                                                               32.563                                                                             52.873                                                                             50.338                                                                             1.00                                                                              19.17            1DLC3947                    ATOM  3824                                                                              CD1                                                                               PHE 532                                                                               33.496                                                                             53.066                                                                             51.356                                                                             1.00                                                                              18.16            1DLC3948                    ATOM  3825                                                                              CD2                                                                               PHE 532                                                                               31.264                                                                             53.337                                                                             50.527                                                                             1.00                                                                              15.07            1DLC3949                    ATOM  3826                                                                              CE1                                                                               PHE 532                                                                               33.135                                                                             53.708                                                                             52.546                                                                             1.00                                                                              17.02            1DLC3950                    ATOM  3827                                                                              CE2                                                                               PHE 532                                                                               30.898                                                                             53.977                                                                             51.708                                                                             1.00                                                                              10.86            1DLC3951                    ATOM  3828                                                                              CZ PHE 532                                                                               31.831                                                                             54.163                                                                             52.719                                                                             1.00                                                                              15.12            1DLC3952                    ATOM  3829                                                                              N  THR 533                                                                               33.998                                                                             49.284                                                                             50.951                                                                             1.00                                                                              17.51            1DLC3953                    ATOM  3830                                                                              CA THR 533                                                                               35.072                                                                             48.827                                                                             51.839                                                                             1.00                                                                              14.72            1DLC3954                    ATOM  3831                                                                              C  THR 533                                                                               35.651                                                                             47.437                                                                             51.531                                                                             1.00                                                                              14.62            1DLC3955                    ATOM  3832                                                                              O  THR 533                                                                               36.485                                                                             46.945                                                                             52.279                                                                             1.00                                                                              16.18            1DLC3956                    ATOM  3833                                                                              CB THR 533                                                                               34.629                                                                             48.834                                                                             53.316                                                                             1.00                                                                              13.10            1DLC3957                    ATOM  3834                                                                              OG1                                                                               THR 533                                                                               33.574                                                                             47.884                                                                             53.498                                                                             1.00                                                                              17.35            1DLC3958                    ATOM  3835                                                                              CG2                                                                               THR 533                                                                               34.140                                                                             50.210                                                                             53.730                                                                             1.00                                                                              9.08             1DLC3959                    ATOM  3836                                                                              N  GLY 534                                                                               35.193                                                                             46.797                                                                             50.457                                                                             1.00                                                                              13.58            1DLC3960                    ATOM  3837                                                                              CA GLY 534                                                                               35.702                                                                             45.480                                                                             50.099                                                                             1.00                                                                              11.66            1DLC3961                    ATOM  3838                                                                              C  GLY 534                                                                               35.064                                                                             44.293                                                                             50.796                                                                             1.00                                                                              11.74            1DLC3962                    ATOM  3839                                                                              O  GLY 534                                                                               35.328                                                                             43.138                                                                             50.450                                                                             1.00                                                                              10.96            1DLC3963                    ATOM  3840                                                                              N  GLY 535                                                                               34.217                                                                             44.586                                                                             51.776                                                                             1.00                                                                              14.26            1DLC3964                    ATOM  3841                                                                              CA GLY 535                                                                               33.524                                                                             43.554                                                                             52.528                                                                             1.00                                                                              14.95            1DLC3965                    ATOM  3842                                                                              C  GLY 535                                                                               32.530                                                                             44.107                                                                             53.542                                                                             1.00                                                                              16.62            1DLC3966                    ATOM  3843                                                                              O  GLY 535                                                                               32.129                                                                             45.269                                                                             53.460                                                                             1.00                                                                              15.43            1DLC3967                    ATOM  3844                                                                              N  ASP 536                                                                               32.131                                                                             43.283                                                                             54.503                                                                             1.00                                                                              15.04            1DLC3968                    ATOM  3845                                                                              CA ASP 536                                                                               31.180                                                                             43.722                                                                             55.514                                                                             1.00                                                                              16.74            1DLC3969                    ATOM  3846                                                                              C  ASP 536                                                                               31.844                                                                             44.387                                                                             56.715                                                                             1.00                                                                              16.82            1DLC3970                    ATOM  3847                                                                              O  ASP 536                                                                               33.066                                                                             44.423                                                                             56.806                                                                             1.00                                                                              18.08            1DLC3971                    ATOM  3848                                                                              CB ASP 536                                                                               30.265                                                                             42.566                                                                             55.935                                                                             1.00                                                                              15.87            1DLC3972                    ATOM  3849                                                                              CG ASP 536                                                                               29.333                                                                             42.124                                                                             54.811                                                                             1.00                                                                              19.56            1DLC3973                    ATOM  3850                                                                              OD1                                                                               ASP 536                                                                               28.899                                                                             42.978                                                                             54.003                                                                             1.00                                                                              19.60            1DLC3974                    ATOM  3851                                                                              OD2                                                                               ASP 536                                                                               29.036                                                                             40.916                                                                             54.724                                                                             1.00                                                                              21.83            1DLC3975                    ATOM  3852                                                                              N  ILE 537                                                                               31.037                                                                             44.932                                                                             57.621                                                                             1.00                                                                              15.79            1DLC3976                    ATOM  3853                                                                              CA ILE 537                                                                               31.561                                                                             45.626                                                                             58.791                                                                             1.00                                                                              15.94            1DLC3977                    ATOM  3854                                                                              C  ILE 537                                                                               30.911                                                                             45.174                                                                             60.094                                                                             1.00                                                                              19.56            1DLC3978                    ATOM  3855                                                                              O  ILE 537                                                                               29.945                                                                             44.411                                                                             60.080                                                                             1.00                                                                              21.80            1DLC3979                    ATOM  3856                                                                              CB ILE 537                                                                               31.392                                                                             47.160                                                                             58.659                                                                             1.00                                                                              17.46            1DLC3980                    ATOM  3857                                                                              CG1                                                                               ILE 537                                                                               29.902                                                                             47.537                                                                             58.605                                                                             1.00                                                                              18.41            1DLC3981                    ATOM  3858                                                                              CG2                                                                               ILE 537                                                                               32.155                                                                             47.668                                                                             57.436                                                                             1.00                                                                              16.62            1DLC3982                    ATOM  3859                                                                              CD1                                                                               ILE 537                                                                               29.628                                                                             49.004                                                                             58.312                                                                             1.00                                                                              13.27            1DLC3983                    ATOM  3860                                                                              N  ILE 538                                                                               31.464                                                                             45.619                                                                             61.219                                                                             1.00                                                                              19.15            1DLC3984                    ATOM  3861                                                                              CA ILE 538                                                                               30.929                                                                             45.263                                                                             62.533                                                                             1.00                                                                              19.28            1DLC3985                    ATOM  3862                                                                              C  ILE 538                                                                               30.189                                                                             46.433                                                                             63.167                                                                             1.00                                                                              17.76            1DLC3986                    ATOM  3863                                                                              O  ILE 538                                                                               30.687                                                                             47.556                                                                             63.207                                                                             1.00                                                                              17.93            1DLC3987                    ATOM  3864                                                                              CB ILE 538                                                                               32.047                                                                             44.748                                                                             63.506                                                                             1.00                                                                              20.58            1DLC3988                    ATOM  3865                                                                              CG1                                                                               ILE 538                                                                               32.256                                                                             43.235                                                                             63.328                                                                             1.00                                                                              21.11            1DLC3989                    ATOM  3866                                                                              CG2                                                                               ILE 538                                                                               31.696                                                                             45.055                                                                             64.977                                                                             1.00                                                                              15.08            1DLC3990                    ATOM  3867                                                                              CD1                                                                               ILE 538                                                                               32.758                                                                             42.812                                                                             61.968                                                                             1.00                                                                              22.07            1DLC3991                    ATOM  3868                                                                              N  GLN 539                                                                               28.978                                                                             46.154                                                                             63.626                                                                             1.00                                                                              19.91            1DLC3992                    ATOM  3869                                                                              CA GLN 539                                                                               28.139                                                                             47.142                                                                             64.283                                                                             1.00                                                                              21.14            1DLC3993                    ATOM  3870                                                                              C  GLN 539                                                                               28.148                                                                             46.929                                                                             65.790                                                                             1.00                                                                              21.70            1DLC3994                    ATOM  3871                                                                              O  GLN 539                                                                               27.816                                                                             45.847                                                                             66.273                                                                             1.00                                                                              23.99            1DLC3995                    ATOM  3872                                                                              CB GLN 539                                                                               26.707                                                                             47.021                                                                             63.780                                                                             1.00                                                                              25.95            1DLC3996                    ATOM  3873                                                                              CG GLN 539                                                                               25.764                                                                             48.075                                                                             64.333                                                                             1.00                                                                              30.75            1DLC3997                    ATOM  3874                                                                              CD GLN 539                                                                               24.328                                                                             47.810                                                                             63.941                                                                             1.00                                                                              32.55            1DLC3998                    ATOM  3875                                                                              OE1                                                                               GLN 539                                                                               23.816                                                                             48.378                                                                             62.980                                                                             1.00                                                                              33.12            1DLC3999                    ATOM  3876                                                                              NE2                                                                               GLN 539                                                                               23.679                                                                             46.918                                                                             64.669                                                                             1.00                                                                              34.27            1DLC4000                    ATOM  3877                                                                              N  CYS 540                                                                               28.528                                                                             47.968                                                                             66.523                                                                             1.00                                                                              23.44            1DLC4001                    ATOM  3878                                                                              CA CYS 540                                                                               28.564                                                                             47.939                                                                             67.983                                                                             1.00                                                                              23.84            1DLC4002                    ATOM  3879                                                                              C  CYS 540                                                                               27.459                                                                             48.828                                                                             68.526                                                                             1.00                                                                              24.50            1DLC4003                    ATOM  3880                                                                              O  CYS 540                                                                               27.331                                                                             49.985                                                                             68.133                                                                             1.00                                                                              26.64            1DLC4004                    ATOM  3881                                                                              CB CYS 540                                                                               29.921                                                                             48.408                                                                             68.505                                                                             1.00                                                                              20.82            1DLC4005                    ATOM  3882                                                                              SG CYS 540                                                                               31.256                                                                             47.385                                                                             67.896                                                                             1.00                                                                              24.17            1DLC4006                    ATOM  3883                                                                              N  THR 541                                                                               26.640                                                                             48.270                                                                             69.405                                                                             1.00                                                                              27.07            1DLC4007                    ATOM  3884                                                                              CA THR 541                                                                               25.528                                                                             49.019                                                                             69.980                                                                             1.00                                                                              28.11            1DLC4008                    ATOM  3885                                                                              C  THR 541                                                                               25.593                                                                             49.152                                                                             71.501                                                                             1.00                                                                              29.79            1DLC4009                    ATOM  3886                                                                              O  THR 541                                                                               24.819                                                                             49.901                                                                             72.088                                                                             1.00                                                                              34.10            1DLC4010                    ATOM  3887                                                                              CB THR 541                                                                               24.165                                                                             48.396                                                                             69.587                                                                             1.00                                                                              26.24            1DLC4011                    ATOM  3888                                                                              OG1                                                                               THR 541                                                                               24.060                                                                             47.068                                                                             70.118                                                                             1.00                                                                              30.21            1DLC4012                    ATOM  3889                                                                              CG2                                                                               THR 541                                                                               24.022                                                                             48.337                                                                             68.079                                                                             1.00                                                                              23.34            1DLC4013                    ATOM  3890                                                                              N  GLU 542                                                                               26.532                                                                             48.459                                                                             72.140                                                                             1.00                                                                              30.44            1DLC4014                    ATOM  3891                                                                              CA GLU 542                                                                               26.654                                                                             48.529                                                                             73.595                                                                             1.00                                                                              29.89            1DLC4015                    ATOM  3892                                                                              C  GLU 542                                                                               28.070                                                                             48.788                                                                             74.082                                                                             1.00                                                                              29.72            1DLC4016                    ATOM  3893                                                                              O  GLU 542                                                                               29.038                                                                             48.531                                                                             73.371                                                                             1.00                                                                              28.80            1DLC4017                    ATOM  3894                                                                              CB GLU 542                                                                               26.137                                                                             47.246                                                                             74.230                                                                             1.00                                                                              34.31            1DLC4018                    ATOM  3895                                                                              CG GLU 542                                                                               24.633                                                                             47.084                                                                             74.162                                                                             1.00                                                                              44.89            1DLC4019                    ATOM  3896                                                                              CD GLU 542                                                                               24.195                                                                             45.678                                                                             74.502                                                                             1.00                                                                              51.23            1DLC4020                    ATOM  3897                                                                              OE1                                                                               GLU 542                                                                               24.867                                                                             45.025                                                                             75.332                                                                             1.00                                                                              56.34            1DLC4021                    ATOM  3898                                                                              OE2                                                                               GLU 542                                                                               23.181                                                                             45.218                                                                             73.930                                                                             1.00                                                                              58.74            1DLC4022                    ATOM  3899                                                                              N  ASN 543                                                                               28.180                                                                             49.306                                                                             75.299                                                                             1.00                                                                              30.82            1DLC4023                    ATOM  3900                                                                              CA ASN 543                                                                               29.479                                                                             49.589                                                                             75.894                                                                             1.00                                                                              33.54            1DLC4024                    ATOM  3901                                                                              C  ASN 543                                                                               30.123                                                                             48.319                                                                             76.434                                                                             1.00                                                                              35.03            1DLC4025                    ATOM  3902                                                                              O  ASN 543                                                                               29.534                                                                             47.626                                                                             77.254                                                                             1.00                                                                              40.96            1DLC4026                    ATOM  3903                                                                              CB ASN 543                                                                               29.338                                                                             50.595                                                                             77.028                                                                             1.00                                                                              33.74            1DLC4027                    ATOM  3904                                                                              CG ASN 543                                                                               29.091                                                                             51.994                                                                             76.531                                                                             1.00                                                                              35.64            1DLC4028                    ATOM  3905                                                                              OD1                                                                               ASN 543                                                                               29.652                                                                             52.412                                                                             75.527                                                                             1.00                                                                              37.08            1DLC4029                    ATOM  3906                                                                              ND2                                                                               ASN 543                                                                               28.267                                                                             52.739                                                                             77.245                                                                             1.00                                                                              39.76            1DLC4030                    ATOM  3907                                                                              N  GLY 544                                                                               31.326                                                                             48.016                                                                             75.969                                                                             1.00                                                                              33.62            1DLC4031                    ATOM  3908                                                                              CA GLY 544                                                                               32.029                                                                             46.833                                                                             76.426                                                                             1.00                                                                              33.21            1DLC4032                    ATOM  3909                                                                              C  GLY 544                                                                               32.845                                                                             46.227                                                                             75.309                                                                             1.00                                                                              34.24            1DLC4033                    ATOM  3910                                                                              O  GLY 544                                                                               33.154                                                                             46.903                                                                             74.328                                                                             1.00                                                                              34.87            1DLC4034                    ATOM  3911                                                                              N  SER 545                                                                               33.226                                                                             44.964                                                                             75.454                                                                             1.00                                                                              34.84            1DLC4035                    ATOM  3912                                                                              CA SER 545                                                                               33.997                                                                             44.305                                                                             74.402                                                                             1.00                                                                              37.03            1DLC4036                    ATOM  3913                                                                              C  SER 545                                                                               33.183                                                                             44.282                                                                             73.118                                                                             1.00                                                                              35.99            1DLC4037                    ATOM  3914                                                                              O  SER 545                                                                               31.978                                                                             44.513                                                                             73.126                                                                             1.00                                                                              39.41            1DLC4038                    ATOM  3915                                                                              CB SER 545                                                                               34.370                                                                             42.873                                                                             74.785                                                                             1.00                                                                              39.43            1DLC4039                    ATOM  3916                                                                              OG SER 545                                                                               35.464                                                                             42.856                                                                             75.677                                                                             1.00                                                                              47.60            1DLC4040                    ATOM  3917                                                                              N  ALA 546                                                                               33.835                                                                             43.972                                                                             72.015                                                                             1.00                                                                              31.02            1DLC4041                    ATOM  3918                                                                              CA ALA 546                                                                               33.133                                                                             43.941                                                                             70.757                                                                             1.00                                                                              27.54            1DLC4042                    ATOM  3919                                                                              C  ALA 546                                                                               33.600                                                                             42.772                                                                             69.929                                                                             1.00                                                                              26.24            1DLC4043                    ATOM  3920                                                                              O  ALA 546                                                                               32.809                                                                             41.914                                                                             69.551                                                                             1.00                                                                              27.56            1DLC4044                    ATOM  3921                                                                              CB ALA 546                                                                               33.356                                                                             45.248                                                                             70.012                                                                             1.00                                                                              28.49            1DLC4045                    ATOM  3922                                                                              N  ALA 547                                                                               34.905                                                                             42.705                                                                             69.705                                                                             1.00                                                                              24.78            1DLC4046                    ATOM  3923                                                                              CA ALA 547                                                                               35.471                                                                             41.643                                                                             68.894                                                                             1.00                                                                              24.38            1DLC4047                    ATOM  3924                                                                              C  ALA 547                                                                               36.864                                                                             41.231                                                                             69.329                                                                             1.00                                                                              25.97            1DLC4048                    ATOM  3925                                                                              O  ALA 547                                                                               37.629                                                                             42.033                                                                             69.874                                                                             1.00                                                                              26.00            1DLC4049                    ATOM  3926                                                                              CB ALA 547                                                                               35.494                                                                             42.068                                                                             67.427                                                                             1.00                                                                              19.70            1DLC4050                    ATOM  3927                                                                              N  THR 548                                                                               37.163                                                                             39.955                                                                             69.114                                                                             1.00                                                                              27.03            1DLC4051                    ATOM  3928                                                                              CA THR 548                                                                               38.467                                                                             39.387                                                                             69.419                                                                             1.00                                                                              24.71            1DLC4052                    ATOM  3929                                                                              C  THR 548                                                                               38.967                                                                             38.779                                                                             68.118                                                                             1.00                                                                              24.86            1DLC4053                    ATOM  3930                                                                              O  THR 548                                                                               38.313                                                                             37.924                                                                             67.516                                                                             1.00                                                                              26.12            1DLC4054                    ATOM  3931                                                                              CB THR 548                                                                               38.401                                                                             38.296                                                                             70.501                                                                             1.00                                                                              24.53            1DLC4055                    ATOM  3932                                                                              OG1                                                                               THR 548                                                                               37.845                                                                             38.849                                                                             71.699                                                                             1.00                                                                              26.86            1DLC4056                    ATOM  3933                                                                              CG2                                                                               THR 548                                                                               39.805                                                                             37.768                                                                             70.805                                                                             1.00                                                                              23.92            1DLC4057                    ATOM  3934                                                                              N  ILE 549                                                                               40.090                                                                             39.293                                                                             67.651                                                                             1.00                                                                              24.94            1DLC4058                    ATOM  3935                                                                              CA ILE 549                                                                               40.694                                                                             38.836                                                                             66.418                                                                             1.00                                                                              24.02            1DLC4b59                    ATOM  3936                                                                              C  ILE 549                                                                               42.085                                                                             38.263                                                                             66.693                                                                             1.00                                                                              23.26            1DLC4060                    ATOM  3937                                                                              O  ILE 549                                                                               42.839                                                                             38.798                                                                             67.503                                                                             1.00                                                                              21.17            1DLC4061                    ATOM  3938                                                                              CB ILE 549                                                                               40.730                                                                             39.992                                                                             65.387                                                                             1.00                                                                              25.33            1DLC4062                    ATOM  3939                                                                              CG1                                                                               ILE 549                                                                               41.441                                                                             39.562                                                                             64.104                                                                             1.00                                                                              26.33            1DLC4063                    ATOM  3940                                                                              CG2                                                                               ILE 549                                                                               41.342                                                                             41.241                                                                             66.004                                                                             1.00                                                                              27.68            1DLC4064                    ATOM  3941                                                                              CD1                                                                               ILE 549                                                                               41.136                                                                             40.472                                                                             62.934                                                                             1.00                                                                              28.86            1DLC4065                    ATOM  3942                                                                              N  TYR 550                                                                               42.375                                                                             37.116                                                                             66.089                                                                             1.00                                                                              24.17            1DLC4066                    ATOM  3943                                                                              CA TYR 550                                                                               43.661                                                                             36.461                                                                             66.272                                                                             1.00                                                                              24.37            1DLC4067                    ATOM  3944                                                                              C  TYR 550                                                                               44.674                                                                             37.003                                                                             65.272                                                                             1.00                                                                              26.11            1DLC4068                    ATOM  3945                                                                              O  TYR 550                                                                               44.429                                                                             37.047                                                                             64.065                                                                             1.00                                                                              29.47            1DLC4069                    ATOM  3946                                                                              CB TYR 550                                                                               43.522                                                                             34.949                                                                             66.131                                                                             1.00                                                                              25.12            1DLC4070                    ATOM  3947                                                                              CG TYR 550                                                                               44.776                                                                             34.184                                                                             66.470                                                                             1.00                                                                              24.27            1DLC4071                    ATOM  3948                                                                              CD1                                                                               TYR 550                                                                               45.802                                                                             34.041                                                                             65.533                                                                             1.00                                                                              26.12            1DLC4072                    ATOM  3949                                                                              CD2                                                                               TYR 550                                                                               44.932                                                                             33.590                                                                             67.721                                                                             1.00                                                                              23.82            1DLC4073                    ATOM  3950                                                                              CE1                                                                               TYR 550                                                                               46.944                                                                             33.327                                                                             65.827                                                                             1.00                                                                              22.97            1DLC4074                    ATOM  3951                                                                              CE2                                                                               TYR 550                                                                               46.075                                                                             32.669                                                                             68.025                                                                             1.00                                                                              22.49            1DLC4075                    ATOM  3952                                                                              CZ TYR 550                                                                               47.071                                                                             32.743                                                                             67.073                                                                             1.00                                                                              23.77            1DLC4076                    ATOM  3953                                                                              OH TYR 550                                                                               48.194                                                                             32.015                                                                             67.361                                                                             1.00                                                                              31.16            1DLC4077                    ATOM  3954                                                                              N  VAL 551                                                                               45.836                                                                             37.362                                                                             65.791                                                                             1.00                                                                              24.14            1DLC4078                    ATOM  3955                                                                              CA VAL 551                                                                               46.893                                                                             37.947                                                                             64.995                                                                             1.00                                                                              24.15            1DLC4079                    ATOM  3956                                                                              C  VAL 551                                                                               48.182                                                                             37.117                                                                             64.962                                                                             1.00                                                                              23.16            1DLC4080                    ATOM  3957                                                                              O  VAL 551                                                                               48.576                                                                             36.522                                                                             65.962                                                                             1.00                                                                              23.67            1DLC4081                    ATOM  3958                                                                              CB VAL 551                                                                               47.132                                                                             39.393                                                                             65.500                                                                             1.00                                                                              21.76            1DLC4082                    ATOM  3959                                                                              CG1                                                                               VAL 551                                                                               48.555                                                                             39.817                                                                             65.337                                                                             1.00                                                                              27.10            1DLC4083                    ATOM  3960                                                                              CG2                                                                               VAL 551                                                                               46.210                                                                             40.334                                                                             64.761                                                                             1.00                                                                              23.25            1DLC4084                    ATOM  3961                                                                              N  THR 552                                                                               48.810                                                                             37.065                                                                             63.792                                                                             1.00                                                                              23.48            1DLC4085                    ATOM  3962                                                                              CA THR 552                                                                               50.057                                                                             36.324                                                                             63.597                                                                             1.00                                                                              24.21            1DLC4086                    ATOM  3963                                                                              C  THR 552                                                                               51.219                                                                             37.238                                                                             63.229                                                                             1.00                                                                              24.68            1DLC4087                    ATOM  3964                                                                              O  THR 552                                                                               51.314                                                                             37.698                                                                             62.096                                                                             1.00                                                                              25.97            1DLC4088                    ATOM  3965                                                                              CB THR 552                                                                               49.928                                                                             35.277                                                                             62.471                                                                             1.00                                                                              23.38            1DLC4089                    ATOM  3966                                                                              OG1                                                                               THR 552                                                                               48.951                                                                             34.300                                                                             62.838                                                                             1.00                                                                              29.47            1DLC4090                    ATOM  3967                                                                              CG2                                                                               THR 552                                                                               51.251                                                                             34.579                                                                             62.225                                                                             1.00                                                                              23.28            1DLC4091                    ATOM  3968                                                                              N  PRO 553                                                                               52.096                                                                             37.548                                                                             64.193                                                                             1.00                                                                              30.06            1DLC4092                    ATOM  3969                                                                              CA PRO 553                                                                               53.254                                                                             38.416                                                                             63.925                                                                             1.00                                                                              31.84            1DLC4093                    ATOM  3970                                                                              C  PRO 553                                                                               54.218                                                                             37.699                                                                             62.977                                                                             1.00                                                                              33.44            1DLC4094                    ATOM  3971                                                                              O  PRO 553                                                                               54.444                                                                             36.497                                                                             63.123                                                                             1.00                                                                              32.03            1DLC4095                    ATOM  3972                                                                              CB PRO 553                                                                               53.591                                                                             38.591                                                                             65.313                                                                             1.00                                                                              32.97            1DLC4096                    ATOM  3973                                                                              CG PRO 553                                                                               52.671                                                                             38.468                                                                             66.241                                                                             1.00                                                                              33.91            1DLC4097                    ATOM  3974                                                                              CD PRO 553                                                                               51.962                                                                             37.281                                                                             65.637                                                                             1.00                                                                              32.11            1DLC4098                    ATOM  3975                                                                              N  ASP 554                                                                               54.758                                                                             38.413                                                                             61.993                                                                             1.00                                                                              35.95            1DLC4099                    ATOM  3976                                                                              CA ASP 554                                                                               55.676                                                                             37.788                                                                             61.036                                                                             1.00                                                                              41.00            1DLC4100                    ATOM  3977                                                                              C  ASP 554                                                                               57.150                                                                             37.717                                                                             61.467                                                                             1.00                                                                              42.22            1DLC4101                    ATOM  3978                                                                              O  ASP 554                                                                               57.949                                                                             37.037                                                                             60.829                                                                             1.00                                                                              46.36            1DLC4102                    ATOM  3979                                                                              CB ASP 554                                                                               55.570                                                                             38.457                                                                             59.660                                                                             1.00                                                                              43.46            1DLC4103                    ATOM  3980                                                                              CG ASP 554                                                                               56.373                                                                             39.740                                                                             59.569                                                                             1.00                                                                              46.10            1DLC4104                    ATOM  3981                                                                              OD1                                                                               ASP 554                                                                               56.390                                                                             40.500                                                                             60.563                                                                             1.00                                                                              50.84            1DLC4105                    ATOM  3982                                                                              OD2                                                                               ASP 554                                                                               56.992                                                                             39.985                                                                             58.509                                                                             1.00                                                                              45.05            1DLC4106                    ATOM  3983                                                                              N  VAL 555                                                                               57.524                                                                             38.457                                                                             62.506                                                                             1.00                                                                              42.99            1DLC4107                    ATOM  3984                                                                              CA VAL 555                                                                               58.904                                                                             38.429                                                                             62.991                                                                             1.00                                                                              41.56            1DLC4108                    ATOM  3985                                                                              C  VAL 555                                                                               58.988                                                                             39.030                                                                             64.454                                                                             1.00                                                                              45.35            1DLC4109                    ATOM  3986                                                                              O  VAL 555                                                                               58.022                                                                             38.149                                                                             65.208                                                                             1.00                                                                              46.82            1DLC4110                    ATOM  3987                                                                              CB VAL 555                                                                               59.634                                                                             39.778                                                                             62.809                                                                             1.00                                                                              36.93            1DLC4111                    ATOM  3988                                                                              CG1                                                                               VAL 555                                                                               59.739                                                                             40.121                                                                             61.345                                                                             1.00                                                                              36.03            1DLC4112                    ATOM  3989                                                                              CG2                                                                               VAL 555                                                                               58.936                                                                             40.878                                                                             63.583                                                                             1.00                                                                              32.39            1DLC4113                    ATOM  3990                                                                              N  SER 556                                                                               60.174                                                                             37.591                                                                             64.854                                                                             1.00                                                                              48.53            1DLC4114                    ATOM  3991                                                                              CA SER 556                                                                               60.434                                                                             37.149                                                                             66.224                                                                             1.00                                                                              48.94            1DLC4115                    ATOM  3992                                                                              C  SER 556                                                                               60.820                                                                             38.260                                                                             67.211                                                                             1.00                                                                              46.00            1DLC4116                    ATOM  3993                                                                              O  SER 556                                                                               60.361                                                                             38.265                                                                             68.359                                                                             1.00                                                                              48.54            1DLC4117                    ATOM  3994                                                                              CB SER 556                                                                               61.524                                                                             36.079                                                                             66.189                                                                             1.00                                                                              52.10            1DLC4118                    ATOM  3995                                                                              OG SER 556                                                                               62.482                                                                             36.395                                                                             65.177                                                                             1.00                                                                              57.59            1DLC4119                    ATOM  3996                                                                              N  TYR 557                                                                               61.669                                                                             39.188                                                                             66.769                                                                             1.00                                                                              40.86            1DLC4120                    ATOM  3997                                                                              CA TYR 557                                                                               62.129                                                                             40.295                                                                             67.614                                                                             1.00                                                                              35.42            1DLC4121                    ATOM  3998                                                                              C  TYR 557                                                                               61.042                                                                             41.301                                                                             67.985                                                                             1.00                                                                              34.52            1DLC4122                    ATOM  3999                                                                              O  TYR 557                                                                               60.016                                                                             41.395                                                                             67.316                                                                             1.00                                                                              35.21            1DLC4123                    ATOM  4000                                                                              CB TYR 557                                                                               63.295                                                                             41.021                                                                             66.956                                                                             1.00                                                                              30.14            1DLC4124                    ATOM  4001                                                                              CG TYR 557                                                                               62.963                                                                             41.630                                                                             65.615                                                                             1.00                                                                              27.40            1DLC4125                    ATOM  4002                                                                              CD1                                                                               TYR 557                                                                               62.352                                                                             42.886                                                                             65.627                                                                             1.00                                                                              25.94            1DLC4126                    ATOM  4003                                                                              CD2                                                                               TYR 557                                                                               63.288                                                                             40.971                                                                             64.436                                                                             1.00                                                                              20.52            1DLC4127                    ATOM  4004                                                                              CE1                                                                               TYR 557                                                                               62.078                                                                             43.464                                                                             64.301                                                                             1.00                                                                              24.25            1DLC4128                    ATOM  4005                                                                              CE2                                                                               TYR 557                                                                               63.019                                                                             41.542                                                                             63.204                                                                             1.00                                                                              24.51            1DLC4129                    ATOM  4006                                                                              CZ TYR 557                                                                               62.414                                                                             42.787                                                                             63.138                                                                             1.00                                                                              26.31            1DLC4130                    ATOM  4007                                                                              OH TYR 557                                                                               62.135                                                                             43.344                                                                             61.904                                                                             1.00                                                                              29.41            1DLC4131                    ATOM  4008                                                                              N  SER 558                                                                               61.331                                                                             42.118                                                                             68.991                                                                             1.00                                                                              33.34            1DLC4132                    ATOM  4009                                                                              CA SER 558                                                                               60.395                                                                             43.114                                                                             69.512                                                                             1.00                                                                              32.79            1DLC4133                    ATOM  4010                                                                              C  SER 558                                                                               60.019                                                                             44.336                                                                             68.656                                                                             1.00                                                                              31.63            1DLC4134                    ATOM  4011                                                                              O  SER 558                                                                               60.148                                                                             45.481                                                                             69.098                                                                             1.00                                                                              30.68            1DLC4135                    ATOM  4012                                                                              CB SER 558                                                                               60.855                                                                             43.563                                                                             70.904                                                                             1.00                                                                              35.65            1DLC4136                    ATOM  4013                                                                              OG SER 558                                                                               62.262                                                                             43.758                                                                             70.943                                                                             1.00                                                                              41.15            1DLC4137                    ATOM  4014                                                                              N  GLN 559                                                                               59.524                                                                             44.085                                                                             67.447                                                                             1.00                                                                              30.48            1DLC4138                    ATOM  4015                                                                              CA GLN 559                                                                               59.077                                                                             45.140                                                                             66.533                                                                             1.00                                                                              29.46            1DLC4139                    ATOM  4016                                                                              C  GLN 559                                                                               57.911                                                                             45.942                                                                             67.143                                                                             1.00                                                                              31.04            1DLC4140                    ATOM  4017                                                                              O  GLN 559                                                                               56.986                                                                             45.378                                                                             67.738                                                                             1.00                                                                              26.59            1DLC4141                    ATOM  4018                                                                              CB GLN 559                                                                               58.618                                                                             44.519                                                                             65.213                                                                             1.00                                                                              30.68            1DLC4142                    ATOM  4019                                                                              CG GLN 559                                                                               57.983                                                                             45.485                                                                             64.227                                                                             1.00                                                                              30.37            1DLC4143                    ATOM  4020                                                                              CD GLN 559                                                                               58.987                                                                             46.419                                                                             63.591                                                                             1.00                                                                              30.94            1DLC4144                    ATOM  4021                                                                              OE1                                                                               GLN 559                                                                               58.686                                                                             47.634                                                                             63.689                                                                             1.00                                                                              33.08            1DLC4145                    ATOM  4022                                                                              NE2                                                                               GLN 559                                                                               59.984                                                                             45.854                                                                             62.933                                                                             1.00                                                                              32.16            1DLC4146                    ATOM  4023                                                                              N  LYS 560                                                                               57.983                                                                             47.262                                                                             67.003                                                                             1.00                                                                              32.69            1DLC4147                    ATOM  4024                                                                              CA LYS 560                                                                               56.959                                                                             48.156                                                                             67.521                                                                             1.00                                                                              32.07            1DLC4148                    ATOM  4025                                                                              C  LYS 560                                                                               56.011                                                                             46.599                                                                             66.419                                                                             1.00                                                                              28.30            1DLC4149                    ATOM  4026                                                                              O  LYS 560                                                                               56.401                                                                             48.725                                                                             65.256                                                                             1.00                                                                              23.65            1DLC4150                    ATOM  4027                                                                              CB LYS 560                                                                               57.593                                                                             49.380                                                                             68.186                                                                             1.00                                                                              37.57            1DLC4151                    ATOM  4028                                                                              CG LYS 560                                                                               58.226                                                                             49.100                                                                             69.538                                                                             1.00                                                                              44.56            1DLC4152                    ATOM  4029                                                                              CD LYS 560                                                                               59.281                                                                             50.154                                                                             69.855                                                                             1.00                                                                              55.46            1DLC4153                    ATOM  4030                                                                              CE LYS 560                                                                               58.671                                                                             51.528                                                                             70.103                                                                             1.00                                                                              59.12            1DLC4154                    ATOM  4031                                                                              NZ LYS 560                                                                               58.034                                                                             51.582                                                                             71.456                                                                             1.00                                                                              66.07            1DLC4155                    ATOM  4032                                                                              N  TYR 561                                                                               54.762                                                                             48.833                                                                             66.816                                                                             1.00                                                                              28.00            1DLC4156                    ATOM  4033                                                                              CA TYR 561                                                                               53.694                                                                             49.255                                                                             65.919                                                                             1.00                                                                              24.77            1DLC4157                    ATOM  4034                                                                              C  TYR 561                                                                               52.816                                                                             50.369                                                                             66.469                                                                             1.00                                                                              24.89            1DLC4158                    ATOM  4035                                                                              O  TYR 561                                                                               52.771                                                                             50.628                                                                             67.675                                                                             1.00                                                                              25.20            1DLC4159                    ATOM  4036                                                                              CB TYR 561                                                                               52.768                                                                             48.073                                                                             65.623                                                                             1.00                                                                              22.54            1DLC4160                    ATOM  4037                                                                              CG TYR 561                                                                               53.442                                                                             46.903                                                                             64.956                                                                             1.00                                                                              21.90            1DLC4161                    ATOM  4038                                                                              CD1                                                                               TYR 561                                                                               54.015                                                                             45.881                                                                             65.714                                                                             1.00                                                                              19.30            1DLC4162                    ATOM  4039                                                                              CD2                                                                               TYR 561                                                                               53.500                                                                             46.812                                                                             63.566                                                                             1.00                                                                              15.01            1DLC4163                    ATOM  4040                                                                              CE1                                                                               TYR 561                                                                               54.627                                                                             44.801                                                                             65.103                                                                             1.00                                                                              19.55            1DLC4164                    ATOM  4041                                                                              CE2                                                                               TYR 561                                                                               54.109                                                                             45.742                                                                             62.950                                                                             1.00                                                                              16.21            1DLC4165                    ATOM  4042                                                                              CZ TYR 561                                                                               54.666                                                                             44.736                                                                             63.722                                                                             1.00                                                                              20.28            1DLC4166                    ATOM  4043                                                                              OH TYR 561                                                                               55.240                                                                             43.642                                                                             63.107                                                                             1.00                                                                              33.74            1DLC416T                    ATOM  4044                                                                              N  ARG 562                                                                               52.153                                                                             51.C50                                                                             65.544                                                                             1.00                                                                              25.77            1DLC4168                    ATOM  4045                                                                              CA ARG 562                                                                               51.179                                                                             52.094                                                                             65.854                                                                             1.00                                                                              23.64            1DLC4169                    ATOM  4046                                                                              C  ARG 562                                                                               49.907                                                                             51.506                                                                             65.251                                                                             1.00                                                                              23.48            1DLC4170                    ATOM  4047                                                                              O  ARG 562                                                                               49.960                                                                             50.823                                                                             64.216                                                                             1.00                                                                              20.35            1DLC4171                    ATOM  4048                                                                              CB ARG 562                                                                               51.484                                                                             53.414                                                                             65.132                                                                             1.00                                                                              22.03            1DLC4172                    ATOM  4049                                                                              CG ARG 562                                                                               52.666                                                                             54.190                                                                             65.655                                                                             1.00                                                                              30.26            1DLC4173                    ATOM  4050                                                                              CD ARG 562                                                                               52.432                                                                             54.744                                                                             67.051                                                                             1.00                                                                              32.80            1DLC4174                    ATOM  4051                                                                              NE ARG 562                                                                               51.345                                                                             55.719                                                                             67.109                                                                             1.00                                                                              39.02            1DLC4175                    ATOM  4052                                                                              CZ ARG 562                                                                               51.269                                                                             56.825                                                                             66.372                                                                             1.00                                                                              40.34            1DLC4176                    ATOM  4053                                                                              NH1                                                                               ARG 562                                                                               52.217                                                                             57.124                                                                             65.494                                                                             1.00                                                                              42.09            1DLC4177                    ATOM  4054                                                                              NH2                                                                               ARG 562                                                                               50.237                                                                             57.645                                                                             66.521                                                                             1.00                                                                              42.48            1DLC4178                    ATOM  4055                                                                              N  ALA 563                                                                               48.773                                                                             51.741                                                                             65.894                                                                             1.00                                                                              22.02            1DLC4179                    ATOM  4056                                                                              CA ALA 563                                                                               47.515                                                                             51.235                                                                             65.378                                                                             1.00                                                                              18.79            1DLC4180                    ATOM  4057                                                                              C  ALA 563                                                                               46.629                                                                             52.386                                                                             64.933                                                                             1.00                                                                              18.02            1DLC4181                    ATOM  4058                                                                              O  ALA 563                                                                               46.640                                                                             53.461                                                                             65.525                                                                             1.00                                                                              20.34            1DLC4182                    ATOM  4059                                                                              CB ALA 563                                                                               46.800                                                                             50.392                                                                             66.440                                                                             1.00                                                                              18.24            1DLC4183                    ATOM  4060                                                                              N  ARG 564                                                                               45.908                                                                             52.159                                                                             63.846                                                                             1.00                                                                              18.32            1DLC4184                    ATOM  4061                                                                              CA ARG 564                                                                               44.960                                                                             53.118                                                                             63.290                                                                             1.00                                                                              16.43            1DLC4185                    ATOM  4062                                                                              C  ARG 564                                                                               43.631                                                                             52.379                                                                             63.170                                                                             1.00                                                                              18.85            1DLC4186                    ATOM  4063                                                                              O  ARG 564                                                                               43.602                                                                             51.185                                                                             62.858                                                                             1.00                                                                              17.80            1DLC4187                    ATOM  4064                                                                              CB ARG 564                                                                               45.338                                                                             53.481                                                                             61.874                                                                             1.00                                                                              15.45            1DLC4188                    ATOM  4065                                                                              CG ARG 564                                                                               46.236                                                                             54.635                                                                             61.654                                                                             1.00                                                                              14.12            1DLC4189                    ATOM  4066                                                                              CD ARG 564                                                                               46.452                                                                             54.611                                                                             60.165                                                                             1.00                                                                              18.52            1DLC4190                    ATOM  4067                                                                              NE ARG 564                                                                               47.230                                                                             55.713                                                                             59.648                                                                             1.00                                                                              20.74            1DLC4191                    ATOM  4068                                                                              CZ ARG 564                                                                               47.640                                                                             55.791                                                                             58.390                                                                             1.00                                                                              18.32            1DLC4192                    ATOM  4069                                                                              NH1                                                                               ARG 564                                                                               47.359                                                                             54.825                                                                             57.523                                                                             1.00                                                                              13.13            1DLC4193                    ATOM  4070                                                                              NH2                                                                               ARG 564                                                                               48.288                                                                             56.872                                                                             57.998                                                                             1.00                                                                              26.68            1DLC4194                    ATOM  4071                                                                              N  ILE 565                                                                               42.527                                                                             53.092                                                                             63.319                                                                             1.00                                                                              18.95            1DLC4195                    ATOM  4072                                                                              CA ILE 565                                                                               41.238                                                                             52.440                                                                             63.187                                                                             1.00                                                                              17.58            1DLC4196                    ATOM  4073                                                                              C  ILE 565                                                                               40.301                                                                             53.192                                                                             62.229                                                                             1.00                                                                              19.97            1DLC4197                    ATOM  4074                                                                              O  ILE 565                                                                               40.261                                                                             54.430                                                                             62.223                                                                             1.00                                                                              20.07            1DLC4198                    ATOM  4075                                                                              CB ILE 565                                                                               40.612                                                                             52.176                                                                             64.579                                                                             1.00                                                                              14.60            1DLC4199                    ATOM  4076                                                                              CG1                                                                               ILE 565                                                                               39.335                                                                             51.353                                                                             64.448                                                                             1.00                                                                              16.02            1DLC4200                    ATOM  4077                                                                              CG2                                                                               ILE 565                                                                               40.402                                                                             53.475                                                                             65.331                                                                             1.00                                                                              15.20            1DLC4201                    ATOM  4078                                                                              CD1                                                                               ILE 565                                                                               38.980                                                                             50.629                                                                             65.727                                                                             1.00                                                                              16.53            1DLC4202                    ATOM  4079                                                                              N  HIS 566                                                                               39.695                                                                             52.438                                                                             61.307                                                                             1.00                                                                              18.25            1DLC4203                    ATOM  4080                                                                              CA HIS 566                                                                               38.752                                                                             52.981                                                                             60.329                                                                             1.00                                                                              14.18            1DLC4204                    ATOM  4081                                                                              C  HIS 566                                                                               37.366                                                                             52.640                                                                             60.859                                                                             1.00                                                                              15.68            1DLC4205                    ATOM  4082                                                                              O  HIS 566                                                                               36.950                                                                             51.482                                                                             60.816                                                                             1.00                                                                              16.47            1DLC4206                    ATOM  4083                                                                              CB HIS 566                                                                               38.960                                                                             52.341                                                                             58.958                                                                             1.00                                                                              11.65            1DLC4207                    ATOM  4084                                                                              CG HIS 566                                                                               38.314                                                                             53.093                                                                             57.831                                                                             1.00                                                                              11.11            1DLC4208                    ATOM  4085                                                                              ND1                                                                               HIS 566                                                                               37.635                                                                             52.465                                                                             56.808                                                                             1.00                                                                              11.16            1DLC4209                    ATOM  4086                                                                              CD2                                                                               HIS 566                                                                               38.258                                                                             54.418                                                                             57.558                                                                             1.00                                                                              11.95            1DLC4210                    ATOM  4087                                                                              CE1                                                                               HIS 566                                                                               37.191                                                                             53.366                                                                             55.951                                                                             1.00                                                                              8.58             1DLC4211                    ATOM  4088                                                                              NE2                                                                               HIS 566                                                                               37.554                                                                             54.561                                                                             56.383                                                                             1.00                                                                              13.33            1DLC4212                    ATOM  4089                                                                              N  TYR 567                                                                               36.654                                                                             53.654                                                                             61.339                                                                             1.00                                                                              16.40            1DLC4213                    ATOM  4090                                                                              CA TYR 567                                                                               35.326                                                                             53.471                                                                             61.935                                                                             1.00                                                                              17.25            1DLC4214                    ATOM  4091                                                                              C  TYR 567                                                                               34.356                                                                             54.630                                                                             61.612                                                                             1.00                                                                              17.40            1DLC4215                    ATOM  4092                                                                              O  TYR 567                                                                               34.730                                                                             55.628                                                                             60.982                                                                             1.00                                                                              17.78            1DLC4216                    ATOM  4093                                                                              CB TYR 567                                                                               35.485                                                                             53.406                                                                             63.471                                                                             1.00                                                                              13.75            1DLC4217                    ATOM  4094                                                                              CG TYR 567                                                                               35.831                                                                             54.771                                                                             64.026                                                                             1.00                                                                              17.11            1DLC4218                    ATOM  4095                                                                              CD1                                                                               TYR 567                                                                               37.075                                                                             55.356                                                                             63.767                                                                             1.00                                                                              16.44            1DLC4219                    ATOM  4096                                                                              CD2                                                                               TYR 567                                                                               34.866                                                                             55.549                                                                             64.674                                                                             1.00                                                                              18.59            1DLC4220                    ATOM  4097                                                                              E1 TYR 567                                                                               37.341                                                                             56.675                                                                             64.121                                                                             1.00                                                                              14.77            1DLC4221                    ATOM  4098                                                                              CE2                                                                               TYR 567                                                                               35.129                                                                             56.872                                                                             65.033                                                                             1.00                                                                              14.24            1DLC4222                    ATOM  4099                                                                              CZ TYR 567                                                                               36.365                                                                             57.423                                                                             64.751                                                                             1.00                                                                              12.88            1DLC4223                    ATOM  4100                                                                              OH TYR 567                                                                               36.624                                                                             58.727                                                                             65.094                                                                             1.00                                                                              18.70            1DLC4224                    ATOM  4101                                                                              N  ALA 568                                                                               33.128                                                                             54.491                                                                             62.114                                                                             1.00                                                                              15.14            1DLC4225                    ATOM  4102                                                                              CA ALA 568                                                                               32.062                                                                             55.486                                                                             61.997                                                                             1.00                                                                              11.71            1DLC4226                    ATOM  4103                                                                              C  ALA 568                                                                               31.335                                                                             55.432                                                                             63.347                                                                             1.00                                                                              13.73            1DLC4227                    ATOM  4104                                                                              O  ALA 568                                                                               31.115                                                                             54.349                                                                             63.895                                                                             1.00                                                                              14.98            1DLC4228                    ATOM  4105                                                                              CB ALA 568                                                                               31.119                                                                             55.140                                                                             60.872                                                                             1.00                                                                              8.00             1DLC4229                    ATOM  4106                                                                              N  SER 569                                                                               31.010                                                                             56.588                                                                             63.913                                                                             1.00                                                                              12.74            1DLC4230                    ATOM  4107                                                                              CA SER 569                                                                               30.344                                                                             56.623                                                                             65.209                                                                             1.00                                                                              13.22            1DLC4231                    ATOM  4108                                                                              C  SER 569                                                                               29.342                                                                             57.768                                                                             65.333                                                                             1.00                                                                              19.84            1DLC4232                    ATOM  4109                                                                              O  SER 569                                                                               29.544                                                                             58.847                                                                             64.767                                                                             1.00                                                                              23.01            1DLC4233                    ATOM  4110                                                                              CB SER 569                                                                               31.384                                                                             56.751                                                                             66.322                                                                             1.00                                                                              10.39            1DLC4234                    ATOM  4111                                                                              OG SER 569                                                                               30.781                                                                             56.784                                                                             67.602                                                                             1.00                                                                              12.68            1DLC4235                    ATOM  4112                                                                              N  THR 570                                                                               28.262                                                                             57.530                                                                             66.075                                                                             1.00                                                                              20.82            1DLC4236                    ATOM  4113                                                                              CA THR 570                                                                               27.246                                                                             58.561                                                                             66.302                                                                             1.00                                                                              22.66            1DLC4237                    ATOM  4114                                                                              C  THR 570                                                                               27.608                                                                             59.465                                                                             67.494                                                                             1.00                                                                              24.67            1DLC4238                    ATOM  4115                                                                              O  THR 570                                                                               26.978                                                                             60.496                                                                             67.720                                                                             1.00                                                                              26.92            1DLC4239                    ATOM  4116                                                                              CB THR 570                                                                               25.842                                                                             57.957                                                                             66.517                                                                             1.00                                                                              19.64            1DLC4240                    ATOM  4117                                                                              OG1                                                                               THR 570                                                                               25.870                                                                             57.024                                                                             67.602                                                                             1.00                                                                              17.72            1DLC4241                    ATOM  4118                                                                              CG2                                                                               THR 570                                                                               25.384                                                                             57.248                                                                             65.262                                                                             1.00                                                                              18.85            1DLC4242                    ATOM  4119                                                                              N  SER 571                                                                               28.646                                                                             59.085                                                                             68.237                                                                             1.00                                                                              26.33            1DLC4243                    ATOM  4120                                                                              CA SER 571                                                                               29.107                                                                             59.869                                                                             69.386                                                                             1.00                                                                              26.65            1DLC4244                    ATOM  4121                                                                              C  SER 571                                                                               30.614                                                                             59.783                                                                             69.597                                                                             1.00                                                                              27.37            1DLC4245                    ATOM  4122                                                                              O  SER 571                                                                               31.309                                                                             59.001                                                                             68.942                                                                             1.00                                                                              26.89            1DLC4246                    ATOM  4123                                                                              CB SER 571                                                                               28.437                                                                             59.388                                                                             70.677                                                                             1.00                                                                              28.07            1DLC4247                    ATOM  4124                                                                              OG SER 571                                                                               29.047                                                                             58.203                                                                             71.173                                                                             1.00                                                                              26.73            1DLC4248                    ATOM  4125                                                                              N  GLN 572                                                                               31.113                                                                             60.621                                                                             70.502                                                                             1.00                                                                              29.31            1DLC4249                    ATOM  4126                                                                              CA GLN 572                                                                               32.520                                                                             60.596                                                                             70.871                                                                             1.00                                                                              27.70            1DLC4250                    ATOM  4127                                                                              C  GLN 572                                                                               32.645                                                                             59.287                                                                             71.648                                                                             1.00                                                                              25.42            1DLC4251                    ATOM  4128                                                                              O  GLN 572                                                                               31.771                                                                             58.935                                                                             72.444                                                                             1.00                                                                              25.29            1DLC4252                    ATOM  4129                                                                              CB GLN 572                                                                               32.891                                                                             61.789                                                                             71.763                                                                             1.00                                                                              31.54            1DLC4253                    ATOM  4130                                                                              CG GLN 572                                                                               32.791                                                                             63.161                                                                             71.076                                                                             1.00                                                                              40.28            1DLC4254                    ATOM  4131                                                                              CD GLN 572                                                                               33.796                                                                             64.189                                                                             71.616                                                                             1.00                                                                              45.09            1DLC4255                    ATOM  4132                                                                              OE1                                                                               GLN 572                                                                               34.886                                                                             64.347                                                                             71.064                                                                             1.00                                                                              49.93            1DLC4256                    ATOM  4133                                                                              NE2                                                                               GLN 572                                                                               33.428                                                                             64.892                                                                             72.685                                                                             1.00                                                                              44.38            1DLC4257                    ATOM  4134                                                                              N  ILE 573                                                                               33.702                                                                             58.543                                                                             71.379                                                                             1.00                                                                              25.62            1DLC4258                    ATOM  4135                                                                              CA ILE 573                                                                               33.891                                                                             57.252                                                                             72.027                                                                             1.00                                                                              24.87            1DLC4259                    ATOM  4136                                                                              C  ILE 573                                                                               35.318                                                                             56.964                                                                             72.451                                                                             1.00                                                                              23.49            1DLC4260                    ATOM  4137                                                                              O  ILE 573                                                                               36.244                                                                             57.724                                                                             72.165                                                                             1.00                                                                              24.22            1DLC4261                    ATOM  4138                                                                              CB ILE 573                                                                               33.472                                                                             56.120                                                                             71.084                                                                             1.00                                                                              24.02            1DLC4262                    ATOM  4139                                                                              CG1                                                                               ILE 573                                                                               34.175                                                                             56.308                                                                             69.731                                                                             1.00                                                                              20.45            1DLC4263                    ATOM  4140                                                                              CG2                                                                               ILE 573                                                                               31.954                                                                             56.080                                                                             70.962                                                                             1.00                                                                              23.19            1DLC4264                    ATOM  4141                                                                              CD1                                                                               ILE 573                                                                               33.929                                                                             55.210                                                                             68.750                                                                             1.00                                                                              21.25            1DLC4265                    ATOM  4142                                                                              N  THR 574                                                                               35.477                                                                             55.856                                                                             73.156                                                                             1.00                                                                              21.66            1DLC4266                    ATOM  4143                                                                              CA THR 574                                                                               36.786                                                                             55.424                                                                             73.591                                                                             1.00                                                                              19.94            1DLC4267                    ATOM  4144                                                                              C  THR 574                                                                               36.991                                                                             54.009                                                                             73.106                                                                             1.00                                                                              21.16            1DLC4268                    ATOM  4145                                                                              O  THR 574                                                                               36.142                                                                             53.140                                                                             73.300                                                                             1.00                                                                              20.88            1DLC4269                    ATOM  4146                                                                              CB THR 574                                                                               36.936                                                                             55.453                                                                             75.123                                                                             1.00                                                                              21.34            1DLC4270                    ATOM  4147                                                                              OG1                                                                               THR 574                                                                               36.902                                                                             56.808                                                                             75.579                                                                             1.00                                                                              27.16            1DLC4271                    ATOM  4148                                                                              CG2                                                                               THR 574                                                                               38.251                                                                             54.835                                                                             75.549                                                                             1.00                                                                              18.62            1DLC4272                    ATOM  4149                                                                              N  PHE 575                                                                               38.085                                                                             53.806                                                                             72.392                                                                             1.00                                                                              21.90            1DLC4273                    ATOM  4150                                                                              CA PHE 575                                                                               38.433                                                                             52.488                                                                             71.904                                                                             1.00                                                                              21.69            1DLC4274                    ATOM  4151                                                                              C  PHE 575                                                                               39.556                                                                             51.976                                                                             72.801                                                                             1.00                                                                              22.38            1DLC4275                    ATOM  4152                                                                              O  PHE 575                                                                               40.441                                                                             52.741                                                                             73.185                                                                             1.00                                                                              24.96            1DLC4276                    ATOM  4153                                                                              CB PHE 575                                                                               38.904                                                                             52.557                                                                             70.447                                                                             1.00                                                                              22.02            1DLC4277                    ATOM  4154                                                                              CG PHE 575                                                                               37.782                                                                             52.563                                                                             69.433                                                                             1.00                                                                              22.92            1DLC4278                    ATOM  4155                                                                              CD1                                                                               PHE 575                                                                               36.741                                                                             51.637                                                                             69.514                                                                             1.00                                                                              23.97            1DLC4279                    ATOM  4156                                                                              CD2                                                                               PHE 575                                                                               37.792                                                                             53.462                                                                             68.370                                                                             1.00                                                                              22.78            1DLC4280                    ATOM  4157                                                                              CE1                                                                               PHE 575                                                                               35.729                                                                             51.604                                                                             68.550                                                                             1.00                                                                              23.30            1DLC4281                    ATOM  4158                                                                              CE2                                                                               PHE 575                                                                               36.785                                                                             53.438                                                                             67.402                                                                             1.00                                                                              24.47            1DLC4282                    ATOM  4159                                                                              CZ PHE 575                                                                               35.751                                                                             52.502                                                                             67.495                                                                             1.00                                                                              22.95            1DLC4283                    ATOM  4160                                                                              N  THR 576                                                                               39.470                                                                             50.715                                                                             73.208                                                                             1.00                                                                              22.42            1DLC4284                    ATOM  4161                                                                              CA THR 576                                                                               40.508                                                                             50.112                                                                             74.046                                                                             1.00                                                                              23.02            1DLC4285                    ATOM  4162                                                                              C  THR 576                                                                               41.004                                                                             48.841                                                                             73.362                                                                             1.00                                                                              26.73            1DLC4286                    ATOM  4163                                                                              O  THR 576                                                                               40.217                                                                             48.083                                                                             72.775                                                                             1.00                                                                              27.65            1DLC4287                    ATOM  4164                                                                              CB THR 576                                                                               40.005                                                                             49.761                                                                             75.472                                                                             1.00                                                                              22.77            1DLC4288                    ATOM  4165                                                                              OG1                                                                               THR 576                                                                               39.490                                                                             50.938                                                                             76.107                                                                             1.00                                                                              22.85            1DLC4289                    ATOM  4166                                                                              CG2                                                                               THR 576                                                                               41.151                                                                             49.218                                                                             76.329                                                                             1.00                                                                              20.19            1DLC4290                    ATOM  4167                                                                              N  LEU 577                                                                               42.322                                                                             48.661                                                                             73.364                                                                             1.00                                                                              26.31            1DLC4291                    ATOM  4168                                                                              CA LEU 577                                                                               42.952                                                                             47.491                                                                             72.762                                                                             1.00                                                                              23.97            1DLC4292                    ATOM  4169                                                                              C  LEU 577                                                                               43.588                                                                             46.622                                                                             73.834                                                                             1.00                                                                              22.18            1DLq4293                    ATOM  4170                                                                              O  LEU 577                                                                               44.242                                                                             47.119                                                                             74.752                                                                             1.00                                                                              22.92            1DLC4294                    ATOM  4171                                                                              CB LEU 577                                                                               44.018                                                                             47.900                                                                             71.744                                                                             1.00                                                                              21.75            1DLC4295                    ATOM  4172                                                                              CG LEU 577                                                                               43.586                                                                             48.805                                                                             70.592                                                                             1.00                                                                              22.22            1DLC4296                    ATOM  4173                                                                              CD1                                                                               LEU 577                                                                               44.732                                                                             49.008                                                                             69.614                                                                             1.00                                                                              20.22            1DLC4297                    ATOM  4174                                                                              CD2                                                                               LEU 577                                                                               42.401                                                                             48.193                                                                             69.894                                                                             1.00                                                                              22.18            1DLC4298                    ATOM  4175                                                                              N  SER 578                                                                               43.367                                                                             45.321                                                                             73.721                                                                             1.00                                                                              22.27            1DLC4299                    ATOM  4176                                                                              CA SER 578                                                                               43.926                                                                             44.365                                                                             74.660                                                                             1.00                                                                              22.35            1DLC4300                    ATOM  4177                                                                              C  SER 578                                                                               44.578                                                                             43.224                                                                             73.907                                                                             1.00                                                                              23.31            1DLC4301                    ATOM  4178                                                                              O  SER 578                                                                               44.143                                                                             42.859                                                                             72.814                                                                             1.00                                                                              23.83            1DLC4302                    ATOM  4179                                                                              CB SER 578                                                                               42.839                                                                             43.784                                                                             75.564                                                                             1.00                                                                              21.54            1DLC4303                    ATOM  4180                                                                              OG SER 578                                                                               42.197                                                                             44.801                                                                             76.303                                                                             1.00                                                                              25.56            1DLC4304                    ATOM  4181                                                                              N  LEU 579                                                                               45.659                                                                             42.708                                                                             74.475                                                                             1.00                                                                              23.36            1DLC4305                    ATOM  4182                                                                              CA LEU 579                                                                               46.371                                                                             41.573                                                                             73.910                                                                             1.00                                                                              23.41            1DLC4306                    ATOM  4183                                                                              C  LEU 579                                                                               46.271                                                                             40.490                                                                             74.968                                                                             1.00                                                                              23.47            1DLC4307                    ATOM  4184                                                                              O  LEU 579                                                                               46.635                                                                             40.709                                                                             76.124                                                                             1.00                                                                              21.83            1DLC4308                    ATOM  4185                                                                              CB LEU 579                                                                               47.836                                                                             41.907                                                                             73.655                                                                             1.00                                                                              25.86            1DLC4309                    ATOM  4186                                                                              CG LEU 579                                                                               48.258                                                                             42.090                                                                             72.203                                                                             1.00                                                                              30.80            1DLC4310                    ATOM  4187                                                                              CD1                                                                               LEU 579                                                                               49.782                                                                             42.146                                                                             72.138                                                                             1.00                                                                              31.83            1DLC4311                    ATOM  4188                                                                              CD2                                                                               LEU 579                                                                               47.730                                                                             40.932                                                                             71.362                                                                             1.00                                                                              31.68            1DLC4312                    ATOM  4189                                                                              N  ASP 580                                                                               45.694                                                                             39.357                                                                             74.592                                                                             1.00                                                                              23.35            1DLC4313                    ATOM  4190                                                                              CA ASP 580                                                                               45.514                                                                             38.243                                                                             75.512                                                                             1.00                                                                              22.65            1DLC4314                    ATOM  4191                                                                              C  ASP 580                                                                               44.902                                                                             38.664                                                                             76.853                                                                             1.00                                                                              21.10            1DLC4315                    ATOM  4192                                                                              O  ASP 580                                                                               45.335                                                                             38.238                                                                             77.917                                                                             1.00                                                                              22.53            1DLC4316                    ATOM  4193                                                                              CB ASP 580                                                                               46.832                                                                             37.474                                                                             75.698                                                                             1.00                                                                              26.17            1DLC4317                    ATOM  4194                                                                              CG ASP 580                                                                               47.291                                                                             36.765                                                                             74.416                                                                             1.00                                                                              31.25            1DLC4318                    ATOM  4195                                                                              OD1                                                                               ASP 580                                                                               46.497                                                                             36.658                                                                             73.459                                                                             1.00                                                                              33.31            1DLC4319                    ATOM  4196                                                                              OD2                                                                               ASP 580                                                                               48.450                                                                             36.303                                                                             74.359                                                                             1.00                                                                              36.06            1DLC4320                    ATOM  4197                                                                              N  GLY 581                                                                               43.917                                                                             39.552                                                                             76.786                                                                             1.00                                                                              21.32            1DLC4321                    ATOM  4198                                                                              CA GLY 581                                                                               43.227                                                                             40.002                                                                             77.981                                                                             1.00                                                                              21.27            1DLC4322                    ATOM  4199                                                                              C  GLY 581                                                                               43.824                                                                             41.150                                                                             78.764                                                                             1.00                                                                              22.88            1DLC4323                    ATOM  4200                                                                              O  GLY 581                                                                               43.290                                                                             41.536                                                                             79.805                                                                             1.00                                                                              25.91            1DLC4324                    ATOM  4201                                                                              N  ALA 582                                                                               44.931                                                                             41.698                                                                             78.291                                                                             1.00                                                                              23.56            1DLC4325                    ATOM  4202                                                                              CA ALA 582                                                                               45.571                                                                             42.810                                                                             78.985                                                                             1.00                                                                              21.79            1DLC4326                    ATOM  4203                                                                              C  ALA 582                                                                               45.518                                                                             44.085                                                                             78.136                                                                             1.00                                                                              22.18            1DLC4327                    ATOM  4204                                                                              O  ALA 582                                                                               45.914                                                                             44.083                                                                             76.965                                                                             1.00                                                                              23.55            1DLC4328                    ATOM  4205                                                                              CB ALA 582                                                                               47.005                                                                             42.451                                                                             79.323                                                                             1.00                                                                              19.42            1DLC4329                    ATOM  4206                                                                              N  PRO 583                                                                               44.975                                                                             45.177                                                                             78.698                                                                             1.00                                                                              21.27            1DLC4330                    ATOM  4207                                                                              CA PRO 583                                                                               44.875                                                                             46.448                                                                             77.971                                                                             1.00                                                                              21.05            1DLC4331                    ATOM  4208                                                                              C  PRO 583                                                                               46.252                                                                             47.058                                                                             77.716                                                                             1.00                                                                              22.08            1DLC4332                    ATOM  4209                                                                              O  PRO 583                                                                               47.119                                                                             47.046                                                                             78.592                                                                             1.00                                                                              23.88            1DLC4333                    ATOM  4210                                                                              CB PRO 583                                                                               44.089                                                                             47.344                                                                             78.939                                                                             1.00                                                                              19.25            1DLC4334                    ATOM  4211                                                                              CG PRO 583                                                                               43.411                                                                             46.393                                                                             79.873                                                                             1.00                                                                              18.79            1DLC4335                    ATOM  4212                                                                              CD PRO 583                                                                               44.427                                                                             45.310                                                                             80.059                                                                             1.00                                                                              20.08            1DLC4336                    ATOM  4213                                                                              N  PHE 584                                                                               46.462                                                                             47.585                                                                             76.522                                                                             1.00                                                                              20.46            1DLC4337                    ATOM  4214                                                                              CA PHE 584                                                                               47.734                                                                             48.217                                                                             76.232                                                                             1.00                                                                              22.26            1DLC4338                    ATOM  4215                                                                              C  PHE 584                                                                               47.560                                                                             49.576                                                                             75.572                                                                             1.00                                                                              24.61            1DLC4339                    ATOM  4216                                                                              O  PHE 584                                                                               48.451                                                                             50.416                                                                             75.608                                                                             1.00                                                                              29.88            1DLC4340                    ATOM  4217                                                                              CB PHE 584                                                                               48.622                                                                             47.308                                                                             75.381                                                                             1.00                                                                              17.78            1DLC4341                    ATOM  4218                                                                              CG PHE 584                                                                               48.113                                                                             47.075                                                                             73.992                                                                             1.00                                                                              16.94            1DLC4342                    ATOM  4219                                                                              CD1                                                                               PHE 584                                                                               48.482                                                                             47.921                                                                             72.954                                                                             1.00                                                                              15.22            1DLC4343                    ATOM  4220                                                                              CD2                                                                               PHE 584                                                                               47.313                                                                             45.981                                                                             73.710                                                                             1.00                                                                              12.59            1DLC4344                    ATOM  4221                                                                              CE1                                                                               PHE 584                                                                               48.067                                                                             47.678                                                                             71.666                                                                             1.00                                                                              16.40            1DLC4345                    ATOM  4222                                                                              CE2                                                                               PHE 584                                                                               46.894                                                                             45.730                                                                             72.420                                                                             1.00                                                                              16.89            1DLC4346                    ATOM  4223                                                                              CZ PHE 584                                                                               47.272                                                                             46.578                                                                             71.391                                                                             1.00                                                                              17.05            1DLC4347                    ATOM  4224                                                                              N  ASN 585                                                                               46.399                                                                             49.799                                                                             74.981                                                                             1.00                                                                              25.77            1DLC4348                    ATOM  4225                                                                              CA ASN 585                                                                               46.138                                                                             51.064                                                                             74.319                                                                             1.00                                                                              27.68            1DLC4349                    ATOM  4226                                                                              C  ASN 585                                                                               44.688                                                                             51.488                                                                             74.531                                                                             1.00                                                                              28.54            1DLC4350                    ATOM  4227                                                                              O  ASN 585                                                                               43.770                                                                             50.671                                                                             74.499                                                                             1.00                                                                              30.79            1DLC4351                    ATOM  4228                                                                              CB ASN 585                                                                               46.433                                                                             50.944                                                                             72.822                                                                             1.00                                                                              30.11            1DLC4352                    ATOM  4229                                                                              CG ASN 585                                                                               47.358                                                                             52.038                                                                             72.310                                                                             1.00                                                                              31.24            1DLC4353                    ATOM  4230                                                                              OD1                                                                               ASN 585                                                                               47.347                                                                             53.171                                                                             72.796                                                                             1.00                                                                              36.32            1DLC4354                    ATOM  4231                                                                              ND2                                                                               ASN 585                                                                               48.145                                                                             51.709                                                                             71.303                                                                             1.00                                                                              34.47            1DLC4355                    ATOM  4232                                                                              N  GLN 586                                                                               44.494                                                                             52.764                                                                             74.812                                                                             1.00                                                                              27.87            1DLC4356                    ATOM  4233                                                                              CA GLN 586                                                                               43.161                                                                             53.304                                                                             75.010                                                                             1.00                                                                              28.50            1DLC4357                    ATOM  4234                                                                              C  GLN 586                                                                               43.216                                                                             54.725                                                                             74.525                                                                             1.00                                                                              27.04            1DLC4358                    ATOM  4235                                                                              O  GLN 586                                                                               44.153                                                                             55.445                                                                             74.850                                                                             1.00                                                                              29.74            1DLC4359                    ATOM  4236                                                                              CB GLN 586                                                                               42.782                                                                             53.287                                                                             76.485                                                                             1.00                                                                              29.22            1DLC4360                    ATOM  4237                                                                              CG GLN 586                                                                               41.398                                                                             53.806                                                                             76.740                                                                             1.00                                                                              29.84            1DLC4361                    ATOM  4238                                                                              CD GLN 586                                                                               41.013                                                                             53.713                                                                             78.189                                                                             1.00                                                                              34.57            1DLC4362                    ATOM  4239                                                                              OE1                                                                               GLN 586                                                                               41.628                                                                             54.350                                                                             79.047                                                                             1.00                                                                              35.42            1DLC4363                    ATOM  4240                                                                              NE2                                                                               GLN 586                                                                               40.001                                                                             52.908                                                                             78.481                                                                             1.00                                                                              35.86            1DLC4364                    ATOM  4241                                                                              N  TYR 587                                                                               42.239                                                                             55.131                                                                             73.730                                                                             1.00                                                                              25.37            1DLC4365                    ATOM  4242                                                                              CA TYR 587                                                                               42.248                                                                             56.492                                                                             73.222                                                                             1.00                                                                              26.60            1DLC4366                    ATOM  4243                                                                              C  TYR 587                                                                               40.850                                                                             57.033                                                                             72.971                                                                             1.00                                                                              25.35            1DLC4367                    ATOM  4244                                                                              O  TYR 587                                                                               39.871                                                                             56.292                                                                             72.967                                                                             1.00                                                                              26.48            1DLC4368                    ATOM  4245                                                                              CB TYR 587                                                                               43.087                                                                             56.569                                                                             71.940                                                                             1.00                                                                              24.36            1DLC4369                    ATOM  4246                                                                              CG TYR 587                                                                               43.718                                                                             57.923                                                                             71.683                                                                             1.00                                                                              23.54            1DLC4370                    ATOM  4247                                                                              CD1                                                                               TYR 587                                                                               44.469                                                                             58.558                                                                             72.669                                                                             1.00                                                                              26.89            1DLC4371                    ATOM  4248                                                                              CD2                                                                               TYR 587                                                                               43.599                                                                             58.551                                                                             70.443                                                                             1.00                                                                              23.40            1DLC4372                    ATOM  4249                                                                              CE1                                                                               TYR 587                                                                               45.093                                                                             59.781                                                                             72.427                                                                             1.00                                                                              26.78            1DLC4373                    ATOM  4250                                                                              CE2                                                                               TYR 587                                                                               44.217                                                                             59.774                                                                             70.191                                                                             1.00                                                                              24.34            1DLC4374                    ATOM  4251                                                                              CZ TYR 587                                                                               44.966                                                                             60.379                                                                             71.190                                                                             1.00                                                                              26.40            1DLC4375                    ATOM  4252                                                                              OH TYR 587                                                                               45.616                                                                             61.567                                                                             70.954                                                                             1.00                                                                              29.54            1DLC4376                    ATOM  4253                                                                              N  TYR 588                                                                               40.777                                                                             58.341                                                                             72.782                                                                             1.00                                                                              26.44            1DLC4377                    ATOM  4254                                                                              CA TYR 588                                                                               39.521                                                                             59.022                                                                             72.524                                                                             1.00                                                                              27.44            1DLC4378                    ATOM  4255                                                                              C  TYR 588                                                                               39.356                                                                             59.223                                                                             71.016                                                                             1.00                                                                              26.50            1DLC4379                    ATOM  4256                                                                              O  TYR 588                                                                               40.329                                                                             59.529                                                                             70.320                                                                             1.00                                                                              23.62            1DLC4380                    ATOM  4257                                                                              CB TYR 588                                                                               39.524                                                                             60.372                                                                             73.218                                                                             1.00                                                                              33.96            1DLC4381                    ATOM  4258                                                                              CG TYR 588                                                                               39.899                                                                             60.333                                                                             74.685                                                                             1.00                                                                              47.28            1DLC4382                    ATOM  4259                                                                              CD1                                                                               TYR 588                                                                               41.220                                                                             60.098                                                                             75.091                                                                             1.00                                                                              53.44            1DLC4383                    ATOM  4260                                                                              CD2                                                                               TYR 588                                                                               38.949                                                                             60.612                                                                             75.668                                                                             1.00                                                                              54.01            1DLC4384                    ATOM  4261                                                                              CE1                                                                               TYR 588                                                                               41.583                                                                             60.150                                                                             76.443                                                                             1.00                                                                              58.54            1DLC4385                    ATOM  4262                                                                              CE2                                                                               TYR 588                                                                               39.297                                                                             60.670                                                                             77.018                                                                             1.00                                                                              60.11            1DLC4386                    ATOM  4263                                                                              CZ TYR 588                                                                               40.613                                                                             60.443                                                                             77.404                                                                             1.00                                                                              61.86            1DLC4387                    ATOM  4264                                                                              OH TYR 588                                                                               40.941                                                                             60.543                                                                             78.746                                                                             1.00                                                                              65.13            1DLC4388                    ATOM  4265                                                                              N  PHE 589                                                                               38.132                                                                             59.026                                                                             70.518                                                                             1.00                                                                              25.50            1DLC4389                    ATOM  4266                                                                              CA PHE 589                                                                               37.821                                                                             59.174                                                                             69.089                                                                             1.00                                                                              23.66            1DLC4390                    ATOM  4267                                                                              C  PHE 589                                                                               36.558                                                                             59.994                                                                             68.795                                                                             1.00                                                                              22.64            1DLC4391                    ATOM  4268                                                                              O  PHE 589                                                                               35.549                                                                             59.901                                                                             69.493                                                                             1.00                                                                              23.58            1DLC4392                    ATOM  4269                                                                              CB PHE 589                                                                               37.763                                                                             57.803                                                                             68.414                                                                             1.00                                                                              22.61            1DLC4393                    ATOM  4270                                                                              CG PHE 589                                                                               39.078                                                                             57.071                                                                             68.446                                                                             1.00                                                                              24.27            1DLC4394                    ATOM  4271                                                                              CD1                                                                               PHE 589                                                                               39.422                                                                             56.279                                                                             69.537                                                                             1.00                                                                              24.25            1DLC4395                    ATOM  4272                                                                              CD2                                                                               PHE 589                                                                               39.991                                                                             57.207                                                                             67.408                                                                             1.00                                                                              22.86            1DLC4396                    ATOM  4273                                                                              CE1                                                                               PHE 589                                                                               40.658                                                                             55.638                                                                             69.592                                                                             1.00                                                                              23.24            1DLC4397                    ATOM  4274                                                                              CE2                                                                               PHE 589                                                                               41.229                                                                             56.566                                                                             67.460                                                                             1.00                                                                              22.86            1DLC4398                    ATOM  4275                                                                              CZ PHE 589                                                                               41.559                                                                             55.784                                                                             68.551                                                                             1.00                                                                              19.36            1DLC4399                    ATOM  4276                                                                              N  ASP 590                                                                               36.629                                                                             60.800                                                                             67.749                                                                             1.00                                                                              20.80            1DLC4400                    ATOM  4277                                                                              CA ASP 590                                                                               35.522                                                                             61.668                                                                             67.374                                                                             1.00                                                                              21.27            1DLC4401                    ATOM  4278                                                                              C  ASP 590                                                                               34.286                                                                             61.011                                                                             66.776                                                                             1.00                                                                              23.02            1DLC4402                    ATOM  4279                                                                              O  ASP 590                                                                               34.339                                                                             59.922                                                                             66.206                                                                             1.00                                                                              24.31            1DLC4403                    ATOM  4280                                                                              CB ASP 590                                                                               36.006                                                                             62.740                                                                             66.395                                                                             1.00                                                                              20.90            1DLC4404                    ATOM  4281                                                                              CG ASP 590                                                                               37.235                                                                             63.476                                                                             66.887                                                                             1.00                                                                              21.49            1DLC4405                    ATOM  4282                                                                              OD1                                                                               ASP 590                                                                               37.310                                                                             63.822                                                                             68.089                                                                             1.00                                                                              24.77            1DLC4406                    ATOM  4283                                                                              OD2                                                                               ASP 590                                                                               38.135                                                                             63.704                                                                             66.058                                                                             1.00                                                                              25.71            1DLC4407                    ATOM  4284                                                                              N  LYS 591                                                                               33.170                                                                             61.722                                                                             66.905                                                                             1.00                                                                              25.19            1DLC4408                    ATOM  4285                                                                              CA LYS 591                                                                               31.881                                                                             61.318                                                                             66.352                                                                             1.00                                                                              23.03            1DLC4409                    ATOM  4286                                                                              C  LYS 591                                                                               31.970                                                                             61.618                                                                             64.846                                                                             1.00                                                                              22.08            1DLC4410                    ATOM  4287                                                                              O  LYS 591                                                                               32.554                                                                             62.629                                                                             64.445                                                                             1.00                                                                              22.29            1DLC4411                    ATOM  4288                                                                              CB LYS 591                                                                               30.784                                                                             62.162                                                                             67.007                                                                             1.00                                                                              25.59            1DLC4412                    ATOM  4289                                                                              CG LYS 591                                                                               29.517                                                                             62.378                                                                             66.194                                                                             1.00                                                                              27.04            1DLC4413                    ATOM  4290                                                                              CD LYS 591                                                                               28.657                                                                             63.423                                                                             66.891                                                                             1.00                                                                              32.39            1DLC4414                    ATOM  4291                                                                              CE LYS 591                                                                               27.559                                                                             63.969                                                                             65.997                                                                             1.00                                                                              33.92            1DLC4415                    ATOM  4292                                                                              NZ LYS 591                                                                               26.505                                                                             62.953                                                                             65.788                                                                             1.00                                                                              40.85            1DLC4416                    ATOM  4293                                                                              N  THR 592                                                                               31.460                                                                             60.726                                                                             64.008                                                                             1.00                                                                              20.83            1DLC4417                    ATOM  4294                                                                              CA THR 592                                                                               31.532                                                                             60.961                                                                             62.567                                                                             1.00                                                                              21.77            1DLC4418                    ATOM  4295                                                                              C  THR 592                                                                               30.182                                                                             61.124                                                                             61.878                                                                             1.00                                                                              24.80            1DLC4419                    ATOM  4296                                                                              O  THR 592                                                                               30.114                                                                             61.669                                                                             60.778                                                                             1.00                                                                              27.91            1DLC4420                    ATOM  4297                                                                              CB THR 592                                                                               32.326                                                                             59.855                                                                             61.832                                                                             1.00                                                                              20.67            1DLC4421                    ATOM  4298                                                                              OG1                                                                               THR 592                                                                               31.636                                                                             58.602                                                                             61.933                                                                             1.00                                                                              18.07            1DLC4422                    ATOM  4299                                                                              CG2                                                                               THR 592                                                                               33.715                                                                             59.716                                                                             62.428                                                                             1.00                                                                              20.53            1DLC4423                    ATOM  4300                                                                              N  ILE 593                                                                               29.113                                                                             60.643                                                                             62.510                                                                             1.00                                                                              23.91            1DLC4424                    ATOM  4301                                                                              CA ILE 593                                                                               27.780                                                                             60.741                                                                             61.922                                                                             1.00                                                                              23.00            1DLC4425                    ATOM  4302                                                                              C  ILE 593                                                                               26.700                                                                             61.002                                                                             62.956                                                                             1.00                                                                              25.03            1DLC4426                    ATOM  4303                                                                              O  ILE 593                                                                               26.926                                                                             60.868                                                                             64.156                                                                             1.00                                                                              24.13            1DLC4427                    ATOM  4304                                                                              CB ILE 593                                                                               27.362                                                                             59.431                                                                             61.185                                                                             1.00                                                                              20.64            1DLC4428                    ATOM  4305                                                                              CG1                                                                               ILE 593                                                                               27.403                                                                             58.244                                                                             62.148                                                                             1.00                                                                              18.67            1DLC4429                    ATOM  4306                                                                              CG2                                                                               ILE 593                                                                               28.219                                                                             59.189                                                                             59.962                                                                             1.00                                                                              20.92            1DLC4430                    ATOM  4307                                                                              CD1                                                                               ILE 593                                                                               26.812                                                                             56.980                                                                             61.577                                                                             1.00                                                                              17.37            1DLC4431                    ATOM  4308                                                                              N  ASN 594                                                                               25.512                                                                             61.331                                                                             62.456                                                                             1.00                                                                              27.20            1DLC4432                    ATOM  4309                                                                              CA ASN 594                                                                               24.329                                                                             61.563                                                                             63.281                                                                             1.00                                                                              30.00            1DLC4433                    ATOM  4310                                                                              C  ASN 594                                                                               23.472                                                                             60.305                                                                             63.268                                                                             1.00                                                                              31.97            1DLC4434                    ATOM  4311                                                                              O  ASN 594                                                                               23.499                                                                             59.542                                                                             62.296                                                                             1.00                                                                              32.25            1DLC4435                    ATOM  4312                                                                              CB ASN 594                                                                               23.495                                                                             62.698                                                                             62.712                                                                             1.00                                                                              33.50            1DLC4436                    ATOM  4313                                                                              CG ASN 594                                                                               24.047                                                                             64.042                                                                             63.059                                                                             1.00                                                                              36.33            1DLC4437                    ATOM  4314                                                                              OD1                                                                               ASN 594                                                                               24.231                                                                             64.358                                                                             64.230                                                                             1.00                                                                              40.10            1DLC4438                    ATOM  4315                                                                              ND2                                                                               ASN 594                                                                               24.307                                                                             64.854                                                                             62.049                                                                             1.00                                                                              37.57            1DLC4439                    ATOM  4316                                                                              N  LYS 595                                                                               22.708                                                                             60.084                                                                             64.335                                                                             1.00                                                                              33.91            1DLC4440                    ATOM  4317                                                                              CA LYS 595                                                                               21.833                                                                             58.913                                                                             64.390                                                                             1.00                                                                              35.24            1DLC4441                    ATOM  4318                                                                              C  LYS 595                                                                               20.936                                                                             58.918                                                                             63.159                                                                             1.00                                                                              33.13            1DLC4442                    ATOM  4319                                                                              O  LYS 595                                                                               20.454                                                                             59.970                                                                             62.740                                                                             1.00                                                                              31.59            1DLC4443                    ATOM  4320                                                                              CB LYS 595                                                                               20.958                                                                             58.924                                                                             65.649                                                                             1.00                                                                              38.0O            1DLC4444                    ATOM  4321                                                                              CG LYS 595                                                                               21.602                                                                             58.302                                                                             66.882                                                                             1.00                                                                              45.73            1DLC4445                    ATOM  4322                                                                              CD LYS 595                                                                               20.570                                                                             58.089                                                                             67.993                                                                             1.00                                                                              49.95            1DLC4446                    ATOM  4323                                                                              CE LYS 595                                                                               20.323                                                                             59.344                                                                             68.835                                                                             1.00                                                                              53.81            1DLC4447                    ATOM  4324                                                                              NZ LYS 595                                                                               21.391                                                                             59.568                                                                             69.861                                                                             1.00                                                                              54.01            1DLC4448                    ATOM  4325                                                                              N  GLY 596                                                                               20.803                                                                             57.763                                                                             62.525                                                                             1.00                                                                              34.32            1DLC4449                    ATOM  4326                                                                              CA GLY 596                                                                               19.954                                                                             57.671                                                                             61.352                                                                             1.00                                                                              35.84            1DLC4450                    ATOM  4327                                                                              C  GLY 596                                                                               20.585                                                                             58.014                                                                             60.016                                                                             1.00                                                                              37.27            1DLC4451                    ATOM  4328                                                                              O  GLY 596                                                                               19.939                                                                             57.872                                                                             58.976                                                                             1.00                                                                              39.75            1DLC4452                    ATOM  4329                                                                              N  ASP 597                                                                               21.829                                                                             58.482                                                                             60.023                                                                             1.00                                                                              36.86            1DLC4453                    ATOM  4330                                                                              CA ASP 597                                                                               22.502                                                                             58.810                                                                             58.772                                                                             1.00                                                                              33.14            1DLC4454                    ATOM  4331                                                                              C  ASP 597                                                                               22.864                                                                             57.551                                                                             58.002                                                                             1.00                                                                              30.98            1DLC4455                    ATOM  4332                                                                              O  ASP 597                                                                               23.057                                                                             56.487                                                                             58.589                                                                             1.00                                                                              30.44            1DLC4456                    ATOM  4333                                                                              CB ASP 597                                                                               23.786                                                                             59.599                                                                             59.030                                                                             1.00                                                                              36.15            1DLC4457                    ATOM  4334                                                                              CG ASP 597                                                                               23.530                                                                             61.040                                                                             59.404                                                                             1.00                                                                              38.83            1DLC4458                    ATOM  4335                                                                              OD1                                                                               ASP 597                                                                               22.359                                                                             61.481                                                                             59.389                                                                             1.00                                                                              43.82            1DLC4459                    ATOM  4336                                                                              OD2                                                                               ASP 597                                                                               24.516                                                                             61.739                                                                             59.707                                                                             1.00                                                                              41.04            1DLC4460                    ATOM  4337                                                                              N  THR 598                                                                               22.884                                                                             57.658                                                                             56.681                                                                             1.00                                                                              29.63            1DLC4461                    ATOM  4338                                                                              CA THR 598                                                                               23.283                                                                             56.536                                                                             55.844                                                                             1.00                                                                              32.00            1DLC4462                    ATOM  4339                                                                              C  THR 598                                                                               24.793                                                                             56.650                                                                             55.683                                                                             1.00                                                                              28.95            1DLC4463                    ATOM  4340                                                                              O  THR 598                                                                               25.341                                                                             57.754                                                                             55.645                                                                             1.00                                                                              28.17            1DLC4464                    ATOM  4341                                                                              CB THR 598                                                                               22.640                                                                             56.585                                                                             54.451                                                                             1.00                                                                              37.94            1DLC4465                    ATOM  4342                                                                              OG1                                                                               THR 598                                                                               22.909                                                                             57.857                                                                             53.839                                                                             1.00                                                                              44.78            1DLC4466                    ATOM  4343                                                                              CG2                                                                               THR 598                                                                               21.142                                                                             56.365                                                                             54.560                                                                             1.00                                                                              40.92            1DLC4467                    ATOM  4344                                                                              N  LEU 599                                                                               25.458                                                                             55.510                                                                             55.577                                                                             1.00                                                                              26.90            1DLC4468                    ATOM  4345                                                                              CA LEU 599                                                                               26.908                                                                             55.483                                                                             55.446                                                                             1.00                                                                              24.58            1DLC4469                    ATOM  4346                                                                              C  LEU 599                                                                               27.476                                                                             55.735                                                                             54.049                                                                             1.00                                                                              22.87            1DLC4470                    ATOM  4347                                                                              O  LEU 599                                                                               27.328                                                                             54.911                                                                             53.153                                                                             1.00                                                                              24.74            1DLC4471                    ATOM  4348                                                                              CB LEU 599                                                                               27.449                                                                             54.166                                                                             56.003                                                                             1.00                                                                              22.68            1DLC4472                    ATOM  4349                                                                              CG LEU 599                                                                               27.957                                                                             54.118                                                                             57.449                                                                             1.00                                                                              23.90            1DLC4473                    ATOM  4350                                                                              CD1                                                                               LEU 599                                                                               27.238                                                                             55.102                                                                             58.344                                                                             1.00                                                                              22.47            1DLC4474                    ATOM  4351                                                                              CD2                                                                               LEU 599                                                                               27.829                                                                             52.693                                                                             57.973                                                                             1.00                                                                              23.37            1DLC4475                    ATOM  4352                                                                              N  THR 600                                                                               28.041                                                                             56.922                                                                             53.853                                                                             1.00                                                                              22.39            1DLC4476                    ATOM  4353                                                                              CA THR 600                                                                               28.696                                                                             57.281                                                                             52.593                                                                             1.00                                                                              19.21            1DLC4477                    ATOM  4354                                                                              C  THR 600                                                                               30.187                                                                             57.440                                                                             52.899                                                                             1.00                                                                              19.66            1DLC4478                    ATOM  4355                                                                              O  THR 600                                                                               30.599                                                                             57.338                                                                             54.058                                                                             1.00                                                                              19.55            1DLC4479                    ATOM  4356                                                                              CB THR 600                                                                               28.160                                                                             58.594                                                                             51.976                                                                             1.00                                                                              19.07            1DLC4480                    ATOM  4357                                                                              OG1                                                                               THR 600                                                                               28.297                                                                             59.671                                                                             52.911                                                                             1.00                                                                              19.57            1DLC4481                    ATOM  4358                                                                              CG2                                                                               THR 600                                                                               26.715                                                                             58.444                                                                             51.577                                                                             1.00                                                                              18.04            1DLC4482                    ATOM  4359                                                                              N  TYR 601                                                                               30.986                                                                             57.750                                                                             51.885                                                                             1.00                                                                              17.78            1DLC4483                    ATOM  4360                                                                              CA TYR 601                                                                               32.426                                                                             57.884                                                                             52.072                                                                             1.00                                                                              17.44            1DLC4484                    ATOM  4361                                                                              C  TYR 601                                                                               32.891                                                                             58.710                                                                             53.278                                                                             1.00                                                                              18.41            1DLC4485                    ATOM  4362                                                                              O  TYR 601                                                                               33.715                                                                             58.256                                                                             54.064                                                                             1.00                                                                              18.54            1DLC4486                    ATOM  4363                                                                              CB TYR 601                                                                               33.083                                                                             58.406                                                                             50.797                                                                             1.00                                                                              19.02            1DLC4487                    ATOM  4364                                                                              CG TYR 601                                                                               34.576                                                                             58.213                                                                             50.799                                                                             1.00                                                                              20.72            1DLC4488                    ATOM  4365                                                                              CD1                                                                               TYR 601                                                                               35.132                                                                             56.947                                                                             50.612                                                                             1.00                                                                              23.42            1DLC4489                    ATOM  4366                                                                              CD2                                                                               TYR 601                                                                               35.435                                                                             59.281                                                                             51.036                                                                             1.00                                                                              20.19            1DLC4490                    ATOM  4367                                                                              CE1                                                                               TYR 601                                                                               36.509                                                                             56.747                                                                             50.665                                                                             1.00                                                                              23.81            1DLC4491                    ATOM  4368                                                                              CE2                                                                               TYR 601                                                                               36.809                                                                             59.098                                                                             51.094                                                                             1.00                                                                              18.57            1DLC4492                    ATOM  4369                                                                              CZ TYR 601                                                                               37.344                                                                             57.830                                                                             50.910                                                                             1.00                                                                              25.85            1DLC4493                    ATOM  4370                                                                              OH TYR 601                                                                               38.712                                                                             57.644                                                                             50.988                                                                             1.00                                                                              30.21            1DLC4494                    ATOM  4371                                                                              N  ASN 602                                                                               32.336                                                                             59.905                                                                             53.440                                                                             1.00                                                                              21.65            1DLC4495                    ATOM  4372                                                                              CA ASN 602                                                                               32.721                                                                             60.789                                                                             54.539                                                                             1.00                                                                              19.54            1DLC4496                    ATOM  4373                                                                              C  ASN 602                                                                               32.256                                                                             60.363                                                                             55.923                                                                             1.00                                                                              18.68            1DLC4497                    ATOM  4374                                                                              O  ASN 602                                                                               32.600                                                                             61.003                                                                             56.913                                                                             1.00                                                                              21.51            1DLC4498                    ATOM  4375                                                                              CB ASN 602                                                                               32.248                                                                             62.219                                                                             54.262                                                                             1.00                                                                              22.37            1DLC4499                    ATOM  4376                                                                              CG ASN 602                                                                               33.025                                                                             62.883                                                                             53.142                                                                             1.00                                                                              28.81            1DLC4500                    ATOM  4377                                                                              OD1                                                                               ASN 602                                                                               34.179                                                                             62.546                                                                             52.882                                                                             1.00                                                                              30.93            1DLC4501                    ATOM  4378                                                                              ND2                                                                               ASN 602                                                                               32.393                                                                             63.830                                                                             52.466                                                                             1.00                                                                              33.11            1DLC4502                    ATOM  4379                                                                              N  SER 603                                                                               31.458                                                                             59.305                                                                             55.995                                                                             1.00                                                                              18.60            1DLC4503                    ATOM  4380                                                                              CA SER 603                                                                               30.956                                                                             58.828                                                                             57.286                                                                             1.00                                                                              18.99            1DLC4504                    ATOM  4381                                                                              C  SER 603                                                                               32.080                                                                             58.199                                                                             58.101                                                                             1.00                                                                              20.18            1DLC4505                    ATOM  4382                                                                              O  SER 603                                                                               32.060                                                                             58.219                                                                             59.334                                                                             1.00                                                                              20.27            1DLC4506                    ATOM  4383                                                                              CB SER 603                                                                               29.859                                                                             57.775                                                                             57.094                                                                             1.00                                                                              21.15            1DLC4507                    ATOM  4384                                                                              OG SER 603                                                                               28.932                                                                             58.158                                                                             56.099                                                                             1.00                                                                              22.65            1DLC4508                    ATOM  4385                                                                              N  PHE 604                                                                               33.043                                                                             57.611                                                                             57.400                                                                             1.00                                                                              18.74            1DLC4509                    ATOM  4386                                                                              CA PHE 604                                                                               34.163                                                                             56.959                                                                             58.057                                                                             1.00                                                                              21.05            1DLC4510                    ATOM  4387                                                                              C  PHE 604                                                                               35.337                                                                             57.874                                                                             58.345                                                                             1.00                                                                              22.35            1DLC4511                    ATOM  4388                                                                              O  PHE 604                                                                               35.639                                                                             58.786                                                                             57.571                                                                             1.00                                                                              25.60            1DLC4512                    ATOM  4389                                                                              CB PHE 604                                                                               34.642                                                                             55.761                                                                             57.243                                                                             1.00                                                                              17.33            1DLC4513                    ATOM  4390                                                                              CG PHE 604                                                                               33.728                                                                             54.589                                                                             57.318                                                                             1.00                                                                              19.46            1DLC4514                    ATOM  4391                                                                              CD1                                                                               PHE 604                                                                               32.615                                                                             54.504                                                                             56.478                                                                             1.00                                                                              20.57            1DLC4515                    ATOM  4392                                                                              CD2                                                                               PHE 604                                                                               33.955                                                                             53.584                                                                             58.251                                                                             1.00                                                                              18.69            1DLC4516                    ATOM  4393                                                                              CE1                                                                               PHE 604                                                                               31.735                                                                             53.435                                                                             56.568                                                                             1.00                                                                              21.99            1DLC4517                    ATOM  4394                                                                              CE2                                                                               PHE 604                                                                               33.090                                                                             52.505                                                                             58.359                                                                             1.00                                                                              21.18            1DLC4518                    ATOM  4395                                                                              CZ PHE 604                                                                               31.971                                                                             52.426                                                                             57.515                                                                             1.00                                                                              25.90            1DLC4519                    ATOM  4396                                                                              N  ASN 605                                                                               35.994                                                                             57.610                                                                             59.470                                                                             1.00                                                                              21.14            1DLC4520                    ATOM  4397                                                                              CA ASN 605                                                                               37.168                                                                             58.359                                                                             59.890                                                                             1.00                                                                              19.17            1DLC4521                    ATOM  4398                                                                              C  ASN 605                                                                               38.294                                                                             57.351                                                                             60.132                                                                             1.00                                                                              17.19            1DLC4522                    ATOM  4399                                                                              O  ASN 605                                                                               38.033                                                                             56.195                                                                             60.457                                                                             1.00                                                                              13.48            1DLC4523                    ATOM  4400                                                                              CB ASN 605                                                                               36.866                                                                             59.139                                                                             61.172                                                                             1.00                                                                              20.09            1DLC4524                    ATOM  4401                                                                              CG ASN 605                                                                               38.083                                                                             59.882                                                                             61.715                                                                             1.00                                                                              24.94            1DLC4525                    ATOM  4402                                                                              OD1                                                                               ASN 605                                                                               38.877                                                                             60.446                                                                             60.961                                                                             1.00                                                                              23.59            1DLC4526                    ATOM  4403                                                                              ND2                                                                               ASN 605                                                                               38.230                                                                             59.886                                                                             63.029                                                                             1.00                                                                              23.22            1DLC4527                    ATOM  4404                                                                              N  LEU 606                                                                               39.529                                                                             57.768                                                                             59.862                                                                             1.00                                                                              15.78            1DLC4528                    ATOM  4405                                                                              CA LEU 606                                                                               40.706                                                                             56.929                                                                             60.085                                                                             1.00                                                                              15.38            1DLC4529                    ATOM  4406                                                                              C  LEU 606                                                                               41.546                                                                             57.666                                                                             61.109                                                                             1.00                                                                              14.32            1DLC4530                    ATOM  4407                                                                              O  LEU 606                                                                               42.089                                                                             58.723                                                                             60.824                                                                             1.00                                                                              19.53            1DLC4531                    ATOM  4408                                                                              CB LEU 606                                                                               41.512                                                                             56.726                                                                             58.803                                                                             1.00                                                                              11.43            1DLC4532                    ATOM  4409                                                                              CG LEU 606                                                                               42.691                                                                             55.748                                                                             58.912                                                                             1.00                                                                              13.17            1DLC4533                    ATOM  4410                                                                              CD1                                                                               LEU 606                                                                               42.188                                                                             54.310                                                                             59.013                                                                             1.00                                                                              8.03             1DLC4534                    ATOM  4411                                                                              CD2                                                                               LEU 606                                                                               43.591                                                                             55.891                                                                             57.712                                                                             1.00                                                                              11.28            1DLC4535                    ATOM  4412                                                                              N  ALA 607                                                                               41.610                                                                             57.132                                                                             62.316                                                                             1.00                                                                              14.53            1DLC4536                    ATOM  4413                                                                              CA ALA 607                                                                               42.357                                                                             57.785                                                                             63.376                                                                             1.00                                                                              17.06            1DLC4537                    ATOM  4414                                                                              C  ALA 607                                                                               43.361                                                                             56.866                                                                             64.075                                                                             1.00                                                                              18.57            1DLC4538                    ATOM  4415                                                                              O  ALA 607                                                                               43.101                                                                             55.678                                                                             64.277                                                                             1.00                                                                              21.74            1DLC4539                    ATOM  4416                                                                              CB ALA 607                                                                               41.391                                                                             58.389                                                                             64.386                                                                             1.00                                                                              14.48            1DLC4540                    ATOM  4417                                                                              N  SER 608                                                                               44.512                                                                             57.429                                                                             64.425                                                                             1.00                                                                              18.31            1DLC4541                    ATOM  4418                                                                              CA SER 608                                                                               45.581                                                                             56.695                                                                             65.105                                                                             1.00                                                                              19.59            1DLC4542                    ATOM  4419                                                                              C  SER 608                                                                               45.444                                                                             56.664                                                                             66.617                                                                             1.00                                                                              19.21            1DLC4543                    ATOM  4420                                                                              O  SER 608                                                                               44.771                                                                             57.504                                                                             67.214                                                                             1.00                                                                              22.53            1DLC4544                    ATOM  4421                                                                              CB SER 608                                                                               46.940                                                                             57.343                                                                             64.817                                                                             1.00                                                                              17.65            1DLC4545                    ATOM  4422                                                                              OG SER 608                                                                               47.288                                                                             57.266                                                                             63.450                                                                             1.00                                                                              31.60            1DLC4546                    ATOM  4423                                                                              N  PHE 609                                                                               46.064                                                                             55.669                                                                             67.231                                                                             1.00                                                                              19.10            1DLC4547                    ATOM  4424                                                                              CA PHE 609                                                                               46.111                                                                             55.593                                                                             68.687                                                                             1.00                                                                              20.56            1DLC4548                    ATOM  4425                                                                              C  PHE 609                                                                               47.461                                                                             56.260                                                                             68.959                                                                             1.00                                                                              23.47            1DLC4549                    ATOM  4426                                                                              O  PHE 609                                                                               48.405                                                                             56.100                                                                             68.173                                                                             1.00                                                                              24.46            1DLC4550                    ATOM  4427                                                                              CB PHE 609                                                                               46.158                                                                             54.144                                                                             69.179                                                                             1.00                                                                              18.14            1DLC4551                    ATOM  4428                                                                              CG PHE 609                                                                               44.822                                                                             53.470                                                                             69.239                                                                             1.00                                                                              13.91            1DLC4552                    ATOM  4429                                                                              CD1                                                                               PHE 609                                                                               44.213                                                                             52.994                                                                             68.082                                                                             1.00                                                                              14.21            1DLC4553                    ATOM  4430                                                                              CD2                                                                               PHE 609                                                                               44.183                                                                             53.288                                                                             70.461                                                                             1.00                                                                              12.55            1DLC4554                    ATOM  4431                                                                              CE1                                                                               PHE 609                                                                               42.990                                                                             52.348                                                                             68.144                                                                             1.00                                                                              13.77            1DLC4555                    ATOM  4432                                                                              CE2                                                                               PHE 609                                                                               42.962                                                                             52.643                                                                             70.538                                                                             1.00                                                                              13.77            1DLC4556                    ATOM  4433                                                                              CZ PHE 609                                                                               42.361                                                                             52.170                                                                             69.378                                                                             1.00                                                                              16.49            1DLC4557                    ATOM  4434                                                                              N  SER 610                                                                               47.568                                                                             56.983                                                                             70.063                                                                             1.00                                                                              26.13            1DLC4558                    ATOM  4435                                                                              CA SER 610                                                                               48.810                                                                             57.686                                                                             70.408                                                                             1.00                                                                              30.80            1DLC4559                    ATOM  4436                                                                              C  SER 610                                                                               50.092                                                                             56.849                                                                             70.539                                                                             1.00                                                                              29.67            1DLC4560                    ATOM  4437                                                                              O  SER 610                                                                               51.025                                                                             56.975                                                                             69.748                                                                             1.00                                                                              30.28            1DLC4561                    ATOM  4438                                                                              CB SER 610                                                                               48.604                                                                             58.473                                                                             71.708                                                                             1.00                                                                              34.50            1DLC4562                    ATOM  4439                                                                              OG SER 610                                                                               48.026                                                                             57.642                                                                             72.714                                                                             1.00                                                                              42.82            1DLC4563                    ATOM  4440                                                                              N  THR 611                                                                               50.101                                                                             55.983                                                                             71.542                                                                             1.00                                                                              30.68            1DLC4564                    ATOM  4441                                                                              CA THR 611                                                                               51.235                                                                             55.137                                                                             71.900                                                                             1.00                                                                              33.04            1DLC4565                    ATOM  4442                                                                              C  THR 611                                                                               51.547                                                                             53.913                                                                             71.043                                                                             1.00                                                                              32.68            1DLC4566                    ATOM  4443                                                                              O  THR 611                                                                               50.639                                                                             53.244                                                                             70.553                                                                             1.00                                                                              35.44            1DLC4567                    ATOM  4444                                                                              CB THR 611                                                                               51.037                                                                             54.639                                                                             73.347                                                                             1.00                                                                              35.70            1DLC4568                    ATOM  4445                                                                              OG1                                                                               THR 611                                                                               50.549                                                                             55.722                                                                             74.151                                                                             1.00                                                                              37.55            1DLC4569                    ATOM  4446                                                                              CG2                                                                               THR 611                                                                               52.351                                                                             54.133                                                                             73.943                                                                             1.00                                                                              41.55            1DLC4570                    ATOM  4447                                                                              N  PRO 612                                                                               52.850                                                                             53.613                                                                             70.849                                                                             1.00                                                                              30.50            1DLC4571                    ATOM  4449                                                                              C  PRO 612                                                                               53.382                                                                             51.236                                                                             70.982                                                                             1.00                                                                              25.09            1DLC4573                    ATOM  4450                                                                              O  PRO 612                                                                               53.513                                                                             51.361                                                                             72.203                                                                             1.00                                                                              24.09            1DLC4574                    ATOM  4451                                                                              CB PRO 612                                                                               54.795                                                                             52.883                                                                             69.733                                                                             1.00                                                                              24.58            1DLC4575                    ATOM  4452                                                                              CG PRO 612                                                                               54.792                                                                             54.370                                                                             69.890                                                                             1.00                                                                              30.13            1DLC4576                    ATOM  4453                                                                              CD PRO 612                                                                               53.935                                                                             54.574                                                                             71.102                                                                             1.00                                                                              29.34            1DLC4577                    ATOM  4454                                                                              N  PHE 613                                                                               53.334                                                                             50.048                                                                             70.389                                                                             1.00                                                                              22.86            1DLC4578                    ATOM  4455                                                                              CA PHE 613                                                                               53.317                                                                             48.813                                                                             71.170                                                                             1.00                                                                              16.75            1DLC4579                    ATOM  4456                                                                              C  PHE 613                                                                               53.921                                                                             47.629                                                                             70.413                                                                             1.00                                                                              19.20            1DLC4580                    ATOM  4457                                                                              O  PHE 613                                                                               54.063                                                                             47.673                                                                             69.198                                                                             1.00                                                                              19.97            1DLC4581                    ATOM  4458                                                                              CB PHE 613                                                                               51.861                                                                             48.483                                                                             71.518                                                                             1.00                                                                              17.73            1DLC4582                    ATOM  4459                                                                              CG PHE 613                                                                               50.976                                                                             48.303                                                                             70.305                                                                             1.00                                                                              17.53            1DLC4583                    ATOM  4460                                                                              CD1                                                                               PHE 613                                                                               50.844                                                                             47.050                                                                             69.699                                                                             1.00                                                                              15.34            1DLC4584                    ATOM  4461                                                                              CD2                                                                               PHE 613                                                                               50.316                                                                             49.392                                                                             69.741                                                                             1.00                                                                              15.52            1DLC4585                    ATOM  4462                                                                              CE1                                                                               PHE 613                                                                               50.075                                                                             46.884                                                                             68.550                                                                             1.00                                                                              18.54            1DLC4586                    ATOM  4463                                                                              CE2                                                                               PHE 613                                                                               49.542                                                                             49.242                                                                             68.591                                                                             1.00                                                                              18.60            1DLC4587                    ATOM  4464                                                                              CZ PHE 613                                                                               49.420                                                                             47.985                                                                             67.991                                                                             1.00                                                                              19.20            1DLC4588                    ATOM  4465                                                                              N  GLU 614                                                                               54.252                                                                             46.565                                                                             71.136                                                                             1.00                                                                              22.92            1DLC4589                    ATOM  4466                                                                              CA GLU 614                                                                               54.788                                                                             45.344                                                                             70.521                                                                             1.00                                                                              28.15            1DLC4590                    ATOM  4467                                                                              C  GLU 614                                                                               53.683                                                                             44.278                                                                             70.508                                                                             1.00                                                                              26.61            1DLC4591                    ATOM  4468                                                                              G  GLU 614                                                                               52.791                                                                             44.305                                                                             71.357                                                                             1.00                                                                              28.65            1DLC4592                    ATOM  4469                                                                              CB GLU 614                                                                               55.922                                                                             44.758                                                                             71.352                                                                             1.00                                                                              34.57            1DLC4593                    ATOM  4470                                                                              CG GLU 614                                                                               57.135                                                                             45.603                                                                             71.583                                                                             1.00                                                                              41.25            1DLC4594                    ATOM  4471                                                                              CD GLU 614                                                                               58.068                                                                             44.932                                                                             72.583                                                                             1.00                                                                              48.16            1DLC4595                    ATOM  4472                                                                              OE1                                                                               GLU 614                                                                               58.144                                                                             43.675                                                                             72.601                                                                             1.00                                                                              49.77            1DLC4596                    ATOM  4473                                                                              OE2                                                                               GLU 614                                                                               58.706                                                                             45.662                                                                             73.370                                                                             1.00                                                                              53.23            1DLC4597                    ATOM  4474                                                                              N  LEU 615                                                                               53.773                                                                             43.303                                                                             69.608                                                                             1.00                                                                              26.20            1DLC4598                    ATOM  4475                                                                              CA LEU 615                                                                               52.774                                                                             42.238                                                                             69.558                                                                             1.00                                                                              25.30            1DLC4599                    ATOM  4476                                                                              C  LEU 615                                                                               53.175                                                                             41.073                                                                             70.455                                                                             1.00                                                                              27.80            1DLC4600                    ATOM  4477                                                                              O  LEU 615                                                                               53.465                                                                             39.975                                                                             69.982                                                                             1.00                                                                              30.45            1DLC4601                    ATOM  4478                                                                              CB LEU 615                                                                               52.558                                                                             41.746                                                                             68.128                                                                             1.00                                                                              24.01            1DLC4602                    ATOM  4479                                                                              CG LEU 615                                                                               51.781                                                                             42.673                                                                             67.196                                                                             1.00                                                                              27.00            1DLC4603                    ATOM  4480                                                                              CD1                                                                               LEU 615                                                                               51.591                                                                             41.995                                                                             65.850                                                                             1.00                                                                              26.98            1DLC4604                    ATOM  4481                                                                              CD2                                                                               LEU 615                                                                               50.431                                                                             43.015                                                                             67.805                                                                             1.00                                                                              26.72            1DLC4605                    ATOM  4482                                                                              N  SER 616                                                                               53.162                                                                             41.311                                                                             71.759                                                                             1.00                                                                              28.53            1DLC4606                    ATOM  4483                                                                              CA SER 616                                                                               53.525                                                                             40.292                                                                             72.744                                                                             1.00                                                                              34.72            1DLC4607                    ATOM  4484                                                                              C  SER 616                                                                               52.371                                                                             39.325                                                                             73.044                                                                             1.00                                                                              37.29            1DLC4608                    ATOM  4485                                                                              O  SER 616                                                                               52.207                                                                             38.865                                                                             74.183                                                                             1.00                                                                              40.69            1DLC4609                    ATOM  4486                                                                              CB SER 616                                                                               53.957                                                                             40.975                                                                             74.042                                                                             1.00                                                                              38.38            1DLC4610                    ATOM  4487                                                                              OG SER 616                                                                               52.908                                                                             41.795                                                                             74.545                                                                             1.00                                                                              40.32            1DLC4611                    ATOM  4488                                                                              N  GLY 617                                                                               51.575                                                                             39.027                                                                             72.021                                                                             1.00                                                                              35.36            1DLC4612                    ATOM  4489                                                                              CA GLY 617                                                                               50.439                                                                             38.139                                                                             72.175                                                                             1.00                                                                              28.58            1DLC4613                    ATOM  4490                                                                              C  GLY 617                                                                               49.746                                                                             37.935                                                                             70.846                                                                             1.00                                                                              27.52            1DLC4614                    ATOM  4491                                                                              O  GLY 617                                                                               50.171                                                                             38.483                                                                             69.832                                                                             1.00                                                                              27.48            1DLC4615                    ATOM  4492                                                                              N  ASN 618                                                                               48.673                                                                             37.152                                                                             70.836                                                                             1.00                                                                              26.58            1DLC4616                    ATOM  4493                                                                              CA ASN 618                                                                               47.958                                                                             36.898                                                                             69.588                                                                             1.00                                                                              25.03            1DLC4617                    ATOM  4494                                                                              C  ASN 618                                                                               46.514                                                                             37.351                                                                             69.564                                                                             1.00                                                                              22.65            1DLC4618                    ATOM  4495                                                                              O  ASN 618                                                                               45.993                                                                             37.679                                                                             68.513                                                                             1.00                                                                              24.08            1DLC4619                    ATOM  4496                                                                              CB ASN 618                                                                               47.991                                                                             35.414                                                                             69.237                                                                             1.00                                                                              25.99            1DLC4620                    ATOM  4497                                                                              CG ASN 618                                                                               49.388                                                                             34.872                                                                             69.126                                                                             1.00                                                                              27.81            1DLC4621                    ATOM  4498                                                                              OD1                                                                               ASN 618                                                                               49.858                                                                             34.163                                                                             70.014                                                                             1.00                                                                              32.06            1DLC4622                    ATOM  4499                                                                              ND2                                                                               ASN 618                                                                               50.060                                                                             35.191                                                                             68.038                                                                             1.00                                                                              28.41            1DLC4623                    ATOM  4500                                                                              N  ASN 619                                                                               45.857                                                                             37.337                                                                             70.711                                                                             1.00                                                                              21.28            1DLC4624                    ATOM  4501                                                                              CA ASN 619                                                                               44.453                                                                             37.718                                                                             70.766                                                                             1.00                                                                              23.58            1DLC4625                    ATOM  4502                                                                              C  ASN 619                                                                               44.187                                                                             39.189                                                                             70.986                                                                             1.00                                                                              23.07            1DLC4626                    ATOM  4503                                                                              O  ASN 619                                                                               44.182                                                                             39.670                                                                             72.118                                                                             1.00                                                                              23.17            1DLC4627                    ATOM  4504                                                                              CB ASN 619                                                                               43.718                                                                             36.886                                                                             71.808                                                                             1.00                                                                              24.66            1DLC4628                    ATOM  4505                                                                              CG ASN 619                                                                               43.780                                                                             35.423                                                                             71.500                                                                             1.00                                                                              26.16            1DLC4629                    ATOM  4506                                                                              OD1                                                                               ASN 619                                                                               42.964                                                                             34.912                                                                             70.754                                                                             1.00                                                                              30.61            1DLC4630                    ATOM  4507                                                                              ND2                                                                               ASN 619                                                                               44.790                                                                             34.747                                                                             72.020                                                                             1.00                                                                              27.81            1DLC4631                    ATOM  4508                                                                              N  LEU 620                                                                               43.962                                                                             39.897                                                                             69.888                                                                             1.00                                                                              24.96            1DLC4632                    ATOM  4509                                                                              CA LEU 620                                                                               43.681                                                                             41.320                                                                             69.938                                                                             1.00                                                                              24.70            1DLC4633                    ATOM  4510                                                                              C  LEU 620                                                                               42.184                                                                             41.557                                                                             70.168                                                                             1.00                                                                              26.87            1DLC4634                    ATOM  4511                                                                              O  LEU 620                                                                               41.332                                                                             41.071                                                                             69.421                                                                             1.00                                                                              26.49            1DLC4635                    ATOM  4512                                                                              CB LEU 620                                                                               44.132                                                                             41.996                                                                             68.640                                                                             1.00                                                                              21.52            1DLC4636                    ATOM  4513                                                                              CG LEU 620                                                                               43.980                                                                             43.521                                                                             68.582                                                                             1.00                                                                              21.06            1DLC4637                    ATOM  4514                                                                              CD1                                                                               LEU 620                                                                               44.827                                                                             44.159                                                                             69.665                                                                             1.00                                                                              22.05            1DLC4638                    ATOM  4515                                                                              CD2                                                                               LEU 620                                                                               44.383                                                                             44.042                                                                             67.220                                                                             1.00                                                                              19.94            1DLC4639                    ATOM  4516                                                                              N  GLN 621                                                                               41.871                                                                             42.295                                                                             71.222                                                                             1.00                                                                              26.81            1DLC4640                    ATOM  4517                                                                              CA GLN 621                                                                               40.490                                                                             42.606                                                                             71.533                                                                             1.00                                                                              28.41            1DLC4641                    ATOM  4518                                                                              C  GLN 621                                                                               40.238                                                                             44.107                                                                             71.450                                                                             1.0G                                                                              27.09            1DLC4642                    ATOM  4519                                                                              O  GLN 621                                                                               41.003                                                                             44.909                                                                             71.987                                                                             1.00                                                                              26.35            1DLC4643                    ATOM  4520                                                                              CB GLN 621                                                                               40.127                                                                             42.097                                                                             72.926                                                                             1.00                                                                              30.85            1DLC4644                    ATOM  4521                                                                              CG GLN 621                                                                               38.687                                                                             42.369                                                                             73.303                                                                             1.00                                                                              38.10            1DLC4645                    ATOM  4522                                                                              CD GLN 621                                                                               38.395                                                                             42.019                                                                             74.741                                                                             1.00                                                                              42.94            1DLC4646                    ATOM  4523                                                                              OE1                                                                               GLN 621                                                                               38.025                                                                             40.885                                                                             75.054                                                                             1.00                                                                              46.82            1DLC4647                    ATOM  4524                                                                              NE2                                                                               GLN 621                                                                               38.573                                                                             42.984                                                                             75.635                                                                             1.00                                                                              43.76            1DLC4648                    ATOM  4525                                                                              N  ILE 622                                                                               39.193                                                                             44.480                                                                             70.723                                                                             1.00                                                                              27.04            1DLC4649                    ATOM  4526                                                                              CA ILE 622                                                                               38.819                                                                             45.881                                                                             70.585                                                                             1.00                                                                              24.51            1DLC4650                    ATOM  4527                                                                              C  ILE 622                                                                               37.571                                                                             46.089                                                                             71.440                                                                             1.00                                                                              23.99            1DLC4651                    ATOM  4528                                                                              O  ILE 622                                                                               36.602                                                                             45.342                                                                             71.329                                                                             1.00                                                                              24.51            1DLC4652                    ATOM  4529                                                                              CB ILE 622                                                                               38.491                                                                             46.269                                                                             69.113                                                                             1.00                                                                              25.00            1DLC4653                    ATOM  4530                                                                              CG1                                                                               ILE 622                                                                               39.637                                                                             45.890                                                                             68.169                                                                             1.00                                                                              25.97            1DLC4654                    ATOM  4531                                                                              CG2                                                                               ILE 622                                                                               38.266                                                                             47.772                                                                             69.005                                                                             1.00                                                                              22.97            1DLC4655                    ATOM  4532                                                                              CD1                                                                               ILE 622                                                                               39.668                                                                             44.433                                                                             67.761                                                                             1.00                                                                              32.60            1DLC4656                    ATOM  4533                                                                              N  GLY 623                                                                               37.615                                                                             47.075                                                                             72.323                                                                             1.00                                                                              24.24            1DLC4657                    ATOM  4534                                                                              CA GLY 623                                                                               36.476                                                                             47.360                                                                             73.178                                                                             1.00                                                                              23.29            1DLC4658                    ATOM  4535                                                                              C  GLY 623                                                                               36.019                                                                             48.798                                                                             72.985                                                                             1.00                                                                              27.25            1DLC4659                    ATOM  4536                                                                              O  GLY 623                                                                               36.825                                                                             49.682                                                                             72.673                                                                             1.00                                                                              28.11            1DLC4660                    ATOM  4537                                                                              N  VAL 624                                                                               34.731                                                                             49.048                                                                             73.184                                                                             1.00                                                                              26.21            1DLC4661                    ATOM  4538                                                                              CA VAL 624                                                                               34.19T                                                                             50.390                                                                             73.009                                                                             1.00                                                                              24.65            1DLC4662                    ATOM  4539                                                                              C  VAL 624                                                                               33.390                                                                             50.847                                                                             74.217                                                                             1.00                                                                              25.91            1DLC4663                    ATOM  4540                                                                              O  VAL 624                                                                               32.695                                                                             50.060                                                                             74.854                                                                             1.00                                                                              28.03            1DLC4664                    ATOM  4541                                                                              CB VAL 624                                                                               33.252                                                                             50.470                                                                             71.780                                                                             1.00                                                                              22.56            1DLC4665                    ATOM  4542                                                                              CG1                                                                               VAL 624                                                                               33.075                                                                             51.903                                                                             71.367                                                                             1.00                                                                              21.19            1DLC4666                    ATOM  4543                                                                              CG2                                                                               VAL 624                                                                               33.774                                                                             49.633                                                                             70.624                                                                             1.00                                                                              24.76            1DLC4667                    ATOM  4544                                                                              N  THR 625                                                                               33.528                                                                             52.117                                                                             74.564                                                                             1.00                                                                              25.09            1DLC4668                    ATOM  4545                                                                              CA THR 625                                                                               32.755                                                                             52.693                                                                             75.653                                                                             1.00                                                                              24.39            1DLC4669                    ATOM  4546                                                                              C  THR 625                                                                               32.428                                                                             54.119                                                                             75.281                                                                             1.00                                                                              24.42            1DLC4670                    ATOM  4547                                                                              O  THR 625                                                                               33.051                                                                             54.700                                                                             74.387                                                                             1.00                                                                              22.03            1DLC4671                    ATOM  4548                                                                              CB THR 625                                                                               33.473                                                                             52.690                                                                             77.007                                                                             1.00                                                                              24.18            1DLC4672                    ATOM  4549                                                                              OG1                                                                               THR 625                                                                               34.753                                                                             53.312                                                                             76.877                                                                             1.00                                                                              30.48            1DLC4673                    ATOM  4550                                                                              CG2                                                                               THR 625                                                                               33.610                                                                             51.271                                                                             77.544                                                                             1.00                                                                              25.23            1DLC4674                    ATOM  4551                                                                              N  GLY 626                                                                               31.432                                                                             54.672                                                                             75.956                                                                             1.00                                                                              28.18            1DLC4675                    ATOM  4552                                                                              CA GLY 626                                                                               31.015                                                                             56.034                                                                             75.672                                                                             1.00                                                                              29.72            1DLC4676                    ATOM  4553                                                                              C  GLY 626                                                                               29.721                                                                             56.089                                                                             74.881                                                                             1.00                                                                              30.01            1DLC4677                    ATOM  4554                                                                              O  GLY 626                                                                               29.311                                                                             57.162                                                                             74.438                                                                             1.00                                                                              34.83            1DLC4678                    ATOM  4555                                                                              N  LEU 627                                                                               29.102                                                                             54.931                                                                             74.668                                                                             1.00                                                                              27.34            1DLC4679                    ATOM  4556                                                                              CA LEU 627                                                                               27.840                                                                             54.852                                                                             73.946                                                                             1.00                                                                              28.54            1DLC4680                    ATOM  4557                                                                              C  LEU 627                                                                               26.655                                                                             55.102                                                                             74.872                                                                             1.00                                                                              31.09            1DLC4681                    ATOM  4558                                                                              O  LEU 627                                                                               26.687                                                                             54.772                                                                             76.058                                                                             1.00                                                                              32.97            1DLC4682                    ATOM  4559                                                                              CB LEU 627                                                                               27.668                                                                             53.483                                                                             73.288                                                                             1.00                                                                              25.31            1DLC4683                    ATOM  4560                                                                              CG LEU 627                                                                               28.673                                                                             53.087                                                                             72.211                                                                             1.00                                                                              24.90            1DLC4684                    ATOM  4561                                                                              CD1                                                                               LEU 627                                                                               28.212                                                                             51.813                                                                             71.544                                                                             1.00                                                                              25.05            1DLC4685                    ATOM  4562                                                                              CD2                                                                               LEU 627                                                                               28.784                                                                             54.196                                                                             71.185                                                                             1.00                                                                              26.40            1DLC4686                    ATOM  4563                                                                              N  SER 628                                                                               25.619                                                                             55.711                                                                             74.316                                                                             1.00                                                                              33.11            1DLC4687                    ATOM  4564                                                                              CA SER 628                                                                               24.390                                                                             56.000                                                                             75.038                                                                             1.00                                                                              32.54            1DLC4688                    ATOM  4565                                                                              C  SER 628                                                                               23.306                                                                             55.280                                                                             74.259                                                                             1.00                                                                              34.13            1DLC4689                    ATOM  4566                                                                              O  SER 628                                                                               23.539                                                                             54.854                                                                             73.126                                                                             1.00                                                                              34.40            1DLC4690                    ATOM  4567                                                                              CB SER 628                                                                               24.108                                                                             57.500                                                                             75.031                                                                             1.00                                                                              34.45            1DLC4691                    ATOM  4568                                                                              OG SER 628                                                                               25.205                                                                             58.224                                                                             75.563                                                                             1.00                                                                              43.41            1DLC4692                    ATOM  4569                                                                              N  ALA 629                                                                               22.121                                                                             55.141                                                                             74.842                                                                             1.00                                                                              36.19            1DLC4693                    ATOM  4570                                                                              CA ALA 629                                                                               21.026                                                                             54.462                                                                             74.149                                                                             1.00                                                                              35.18            1DLC4694                    ATOM  4571                                                                              C  ALA 629                                                                               20.802                                                                             55.085                                                                             72.769                                                                             1.00                                                                              32.86            1DLC4695                    ATOM  4572                                                                              O  ALA 629                                                                               20.722                                                                             56.307                                                                             72.632                                                                             1.00                                                                              33.61            1DLC4696                    ATOM  4573                                                                              CB ALA 629                                                                               19.753                                                                             54.536                                                                             74.977                                                                             1.00                                                                              38.53            1DLC4697                    ATOM  4574                                                                              N  GLY 630                                                                               20.776                                                                             54.250                                                                             71.739                                                                             1.00                                                                              31.19            1DLC4698                    ATOM  4575                                                                              CA GLY 630                                                                               20.572                                                                             54.767                                                                             70.397                                                                             1.00                                                                              31.13            1DLC4699                    ATOM  4576                                                                              C  GLY 630                                                                               21.845                                                                             55.068                                                                             69.625                                                                             1.00                                                                              30.12            1DLC4700                    ATOM  4577                                                                              O  GLY 630                                                                               21.797                                                                             55.416                                                                             68.440                                                                             1.00                                                                              29.53            1DLC4701                    ATOM  4578                                                                              N  ASP 631                                                                               22.984                                                                             54.975                                                                             70.303                                                                             1.00                                                                              29.51            1DLC4702                    ATOM  4579                                                                              CA ASP 631                                                                               24.269                                                                             55.204                                                                             69.658                                                                             1.00                                                                              29.05            1DLC4703                    ATOM  4580                                                                              C  ASP 631                                                                               24.772                                                                             53.950                                                                             68.958                                                                             1.00                                                                              26.70            1DLC4704                    ATOM  4581                                                                              O  ASP 631                                                                               24.535                                                                             52.834                                                                             69.409                                                                             1.00                                                                              25.70            1DLC4705                    ATOM  4582                                                                              CB ASP 631                                                                               25.315                                                                             55.686                                                                             70.662                                                                             1.00                                                                              30.55            1DLC4706                    ATOM  4583                                                                              CG ASP 631                                                                               25.248                                                                             57.175                                                                             70.902                                                                             1.00                                                                              29.06            1DLC4707                    ATOM  4584                                                                              OD1                                                                               ASP 631                                                                               24.974                                                                             57.917                                                                             69.940                                                                             1.00                                                                              32.20            1DLC4708                    ATOM  4585                                                                              OD2                                                                               ASP 631                                                                               25.480                                                                             57.608                                                                             72.050                                                                             1.00                                                                              32.19            1DLC4709                    ATOM  4586                                                                              N  LYS 632                                                                               25.448                                                                             54.155                                                                             67.836                                                                             1.00                                                                              27.29            1DLC4710                    ATOM  4587                                                                              CA LYS 632                                                                               26.001                                                                             53.063                                                                             67.043                                                                             1.00                                                                              28.14            1DLC4711                    ATOM  4588                                                                              C  LYS 632                                                                               27.423                                                                             53.376                                                                             66.582                                                                             1.00                                                                              28.21            1DLC4712                    ATOM  4589                                                                              O  LYS 632                                                                               27.751                                                                             54.529                                                                             66.259                                                                             1.00                                                                              27.32            1DLC4713                    ATOM  4590                                                                              CB LYS 632                                                                               25.144                                                                             52.822                                                                             65.796                                                                             1.00                                                                              30.56            1DLC4714                    ATOM  4591                                                                              CG LYS 632                                                                               24.302                                                                             51.570                                                                             65.808                                                                             1.00                                                                              34.27            1DLC4715                    ATOM  4592                                                                              CD LYS 632                                                                               22.833                                                                             51.929                                                                             65.849                                                                             1.00                                                                              38.40            1DLC4716                    ATOM  4593                                                                              CE LYS 632                                                                               21.989                                                                             50.859                                                                             65.198                                                                             1.00                                                                              38.52            1DLC4717                    ATOM  4594                                                                              NZ LYS 632                                                                               22.334                                                                             50.732                                                                             63.756                                                                             1.00                                                                              39.82            1DLC4718                    ATOM  4595                                                                              N  VAL 633                                                                               28.257                                                                             52.337                                                                             66.557                                                                             1.00                                                                              27.38            1DLC4719                    ATOM  4596                                                                              CA VAL 633                                                                               29.644                                                                             52.437                                                                             66.097                                                                             1.00                                                                              21.96            1DLC4720                    ATOM  4597                                                                              C  VAL 633                                                                               29.876                                                                             51.322                                                                             65.082                                                                             1.00                                                                              20.64            1DLC4721                    ATOM  4598                                                                              O  VAL 633                                                                               29.526                                                                             50.173                                                                             65.324                                                                             1.00                                                                              16.03            1DLC4722                    ATOM  4599                                                                              CB VAL 633                                                                               30.665                                                                             52.281                                                                             67.244                                                                             1.00                                                                              20.74            1DLC4723                    ATOM  4600                                                                              CG1                                                                               VAL 633                                                                               32.082                                                                             52.371                                                                             66.701                                                                             1.00                                                                              21.42            1DLC4724                    ATOM  4601                                                                              CG2                                                                               VAL 633                                                                               30.462                                                                             53.360                                                                             68.275                                                                             1.00                                                                              21.81            1DLC4725                    ATOM  4602                                                                              N  TYR 634                                                                               30.393                                                                             51.687                                                                             63.917                                                                             1.00                                                                              21.62            1DLC4726                    ATOM  4603                                                                              CA TYR 634                                                                               30.687                                                                             50.729                                                                             62.859                                                                             1.00                                                                              19.61            1DLC4727                    ATOM  4604                                                                              C  TYR 634                                                                               32.199                                                                             50.649                                                                             62.704                                                                             1.00                                                                              20.81            1DLC4728                    ATOM  4605                                                                              O  TYR 634                                                                               32.872                                                                             51.675                                                                             62.583                                                                             1.00                                                                              19.65            1DLC4729                    ATOM  4606                                                                              CB TYR 634                                                                               30.072                                                                             51.188                                                                             61.541                                                                             1.00                                                                              20.60            1DLC4730                    ATOM  4607                                                                              CG TYR 634                                                                               28.582                                                                             51.418                                                                             61.612                                                                             1.00                                                                              24.53            1DLC4731                    ATOM  4608                                                                              CD1                                                                               TYR 634                                                                               28.069                                                                             52.660                                                                             61.978                                                                             1.00                                                                              22.76            1DLC4732                    ATOM  4609                                                                              CD2                                                                               TYR 634                                                                               27.684                                                                             50.392                                                                             61.306                                                                             1.00                                                                              24.10            1DLC4733                    ATOM  4610                                                                              CE1                                                                               TYR 634                                                                               26.713                                                                             52.877                                                                             62.036                                                                             1.00                                                                              26.60            1DLC4734                    ATOM  4611                                                                              CE2                                                                               TYR 634                                                                               26.321                                                                             50.598                                                                             61.359                                                                             1.00                                                                              24.93            1DLC4735                    ATOM  4612                                                                              CZ TYR 634                                                                               25.839                                                                             51.845                                                                             61.723                                                                             1.00                                                                              29.72            1DLC4736                    ATOM  4613                                                                              OH TYR 634                                                                               24.481                                                                             52.074                                                                             61.754                                                                             1.00                                                                              34.36            1DLC4737                    ATOM  4614                                                                              N  ILE 635                                                                               32.741                                                                             49.438                                                                             62.750                                                                             1.00                                                                              20.73            1DLC4738                    ATOM  4615                                                                              CA ILE 635                                                                               34.182                                                                             49.257                                                                             62.602                                                                             1.00                                                                              18.75            1DLC4739                    ATOM  4616                                                                              C  ILE 635                                                                               34.474                                                                             48.479                                                                             61.340                                                                             1.00                                                                              16.63            1DLC4740                    ATOM  4617                                                                              O  ILE 635                                                                               33.941                                                                             47.398                                                                             61.115                                                                             1.00                                                                              17.24            1DLC4741                    ATOM  4618                                                                              CB ILE 635                                                                               34.811                                                                             48.520                                                                             63.794                                                                             1.00                                                                              20.45            1DLC4742                    ATOM  4619                                                                              CG1                                                                               ILE 635                                                                               34.344                                                                             49.147                                                                             65.119                                                                             1.00                                                                              22.26            1DLC4743                    ATOM  4620                                                                              CG2                                                                               ILE 635                                                                               36.329                                                                             48.591                                                                             63.692                                                                             1.00                                                                              22.68            1DLC4744                    ATOM  4621                                                                              CD1                                                                               ILE 635                                                                               34.684                                                                             48.321                                                                             66.359                                                                             1.00                                                                              21.31            1DLC4745                    ATOM  4622                                                                              N  ASP 636                                                                               35.302                                                                             49.070                                                                             60.499                                                                             1.00                                                                              17.78            1DLC4746                    ATOM  4623                                                                              CA ASP 636                                                                               35.683                                                                             48.464                                                                             59.241                                                                             1.00                                                                              17.49            1DLC4747                    ATOM  4624                                                                              C  ASP 636                                                                               36.993                                                                             47.673                                                                             59.370                                                                             1.00                                                                              18.04            1DLC4748                    ATOM  4625                                                                              O  ASP 636                                                                               37.003                                                                             46.440                                                                             59.251                                                                             1.00                                                                              17.98            1DLC4749                    ATOM  4626                                                                              CB ASP 636                                                                               35.802                                                                             49.561                                                                             58.170                                                                             1.00                                                                              15.99            1DLC4750                    ATOM  4627                                                                              CG ASP 636                                                                               36.303                                                                             49.036                                                                             56.842                                                                             1.00                                                                              18.79            1DLC4751                    ATOM  4628                                                                              OD1                                                                               ASP 636                                                                               35.898                                                                             47.926                                                                             56.440                                                                             1.00                                                                              25.68            1DLC4752                    ATOM  4629                                                                              OD2                                                                               ASP 636                                                                               37.109                                                                             48.733                                                                             56.197                                                                             1.00                                                                              18.48            1DLC4753                    ATOM  4630                                                                              N  LYS 637                                                                               38.083                                                                             48.381                                                                             59.670                                                                             1.00                                                                              18.05            1DLC4754                    ATOM  4631                                                                              CA LYS 637                                                                               39.402                                                                             47.758                                                                             59.775                                                                             1.00                                                                              16.49            1DLC4755                    ATOM  4632                                                                              C  LYS 637                                                                               40.305                                                                             48.342                                                                             60.846                                                                             1.00                                                                              15.84            1DLC4756                    ATOM  4633                                                                              O  LYS 637                                                                               40.099                                                                             49.462                                                                             61.305                                                                             1.00                                                                              19.42            1DLC4757                    ATOM  4634                                                                              CB LYS 637                                                                               40.153                                                                             47.887                                                                             58.441                                                                             1.00                                                                              13.95            1DLC4758                    ATOM  4635                                                                              CG LYS 637                                                                               39.432                                                                             47.343                                                                             57.217                                                                             1.00                                                                              15.81            1DLC4759                    ATOM  4636                                                                              CD LYS 637                                                                               40.290                                                                             47.503                                                                             55.987                                                                             1.00                                                                              15.16            1DLC4760                    ATOM  4637                                                                              CE LYS 637                                                                               39.562                                                                             47.083                                                                             54.729                                                                             1.00                                                                              18.94            1DLC4761                    ATOM  4638                                                                              NZ LYS 637                                                                               38.566                                                                             48.094                                                                             54.290                                                                             1.00                                                                              25.98            1DLC4762                    ATOM  4639                                                                              N  ILE 638                                                                               41.285                                                                             47.547                                                                             61.255                                                                             1.00                                                                              17.01            1DLC4763                    ATOM  4640                                                                              CA ILE 638                                                                               42.312                                                                             47.967                                                                             62.205                                                                             1.00                                                                              18.44            1DLC4764                    ATOM  4641                                                                              C  ILE 638                                                                               43.590                                                                             47.876                                                                             61.359                                                                             1.00                                                                              18.91            1DLC4765                    ATOM  4642                                                                              O  ILE 638                                                                               43.728                                                                             46.979                                                                             60.528                                                                             1.00                                                                              17.29            1DLC4766                    ATOM  4643                                                                              CB ILE 638                                                                               42.402                                                                             47.038                                                                             63.455                                                                             1.00                                                                              19.92            1DLC4767                    ATOM  4644                                                                              CG1                                                                               ILE 638                                                                               43.633                                                                             47.371                                                                             64.303                                                                             1.00                                                                              23.39            1DLC4768                    ATOM  4645                                                                              CG2                                                                               ILE 638                                                                               42.467                                                                             45.589                                                                             63.051                                                                             1.00                                                                              22.91            1DLC4769                    ATOM  4646                                                                              CD1                                                                               ILE 638                                                                               43.463                                                                             48.546                                                                             65.222                                                                             1.00                                                                              25.42            1DLC4770                    ATOM  4647                                                                              N  GLU 639                                                                               44.452                                                                             48.876                                                                             61.467                                                                             1.00                                                                              19.60            1DLC4771                    ATOM  4648                                                                              CA GLU 639                                                                               45.693                                                                             48.893                                                                             60.699                                                                             1.00                                                                              19.14            1DLC4772                    ATOM  4649                                                                              C  GLU 639                                                                               46.903                                                                             48.901                                                                             61.614                                                                             1.00                                                                              19.79            1DLC4773                    ATOM  4650                                                                              O  GLU 639                                                                               46.878                                                                             49.481                                                                             62.704                                                                             1.00                                                                              20.61            1DLC4774                    ATOM  4651                                                                              CB GLU 639                                                                               45.772                                                                             50.131                                                                             59.807                                                                             1.00                                                                              21.25            1DLC4775                    ATOM  4652                                                                              CG GLU 639                                                                               44.596                                                                             50.362                                                                             58.880                                                                             1.00                                                                              20.87            1DLC4776                    ATOM  4653                                                                              CD GLU 639                                                                               44.831                                                                             51.536                                                                             57.938                                                                             1.00                                                                              21.31            1DLC4777                    ATOM  4654                                                                              OE1                                                                               GLU 639                                                                               45.626                                                                             52.437                                                                             58.270                                                                             1.00                                                                              23.01            1DLC4778                    ATOM  4655                                                                              OE2                                                                               GLU 639                                                                               44.225                                                                             51.560                                                                             56.853                                                                             1.00                                                                              23.98            1DLC4779                    ATOM  4656                                                                              N  PHE 640                                                                               47.969                                                                             48.259                                                                             61.162                                                                             1.00                                                                              18.90            1DLC4780                    ATOM  4657                                                                              CA PHE 640                                                                               49.193                                                                             48.212                                                                             61.940                                                                             1.00                                                                              18.35            1DLC4781                    ATOM  4658                                                                              C  PHE 640                                                                               50.310                                                                             48.862                                                                             61.154                                                                             1.00                                                                              18.44            1DLC4782                    ATOM  4659                                                                              O  PHE 640                                                                               50.542                                                                             48.535                                                                             59.986                                                                             1.00                                                                              19.24            1DLC4783                    ATOM  4660                                                                              CB PHE 640                                                                               49.552                                                                             46.775                                                                             62.303                                                                             1.00                                                                              18.10            1DLC4784                    ATOM  4661                                                                              CG PHE 640                                                                               48.503                                                                             46.086                                                                             63.121                                                                             1.00                                                                              19.75            1DLC4785                    ATOM  4662                                                                              CD1                                                                               PHE 640                                                                               47.457                                                                             45.408                                                                             62.504                                                                             1.00                                                                              22.39            1DLC4786                    ATOM  4663                                                                              CD2                                                                               PHE 640                                                                               48.548                                                                             46.122                                                                             64.508                                                                             1.00                                                                              21.02            1DLC4787                    ATOM  4664                                                                              CE1                                                                               PHE 640                                                                               64.471                                                                             44.774                                                                             63.260                                                                             1.00                                                                              23.22            1DLC4788                    ATOM  4665                                                                              CE2                                                                               PHE 640                                                                               47.562                                                                             45.488                                                                             65.275                                                                             1.00                                                                              20.83            1DLC4789                    ATOM  4666                                                                              CZ PHE 640                                                                               46.528                                                                             44.816                                                                             64.649                                                                             1.00                                                                              21.24            1DLC4790                    ATOM  4667                                                                              N  ILE 641                                                                               50.935                                                                             49.855                                                                             61.773                                                                             1.00                                                                              18.54            1DLC4791                    ATOM  4668                                                                              CA ILE 641                                                                               52.032                                                                             50.574                                                                             61.148                                                                             1.00                                                                              17.65            1DLC4792                    ATOM  4669                                                                              C  ILE 641                                                                               53.354                                                                             50.254                                                                             61.825                                                                             1.00                                                                              18.10            1DLC4793                    ATOM  4670                                                                              O  ILE 641                                                                               53.532                                                                             50.515                                                                             63.020                                                                             1.00                                                                              16.34            1DLC4794                    ATOM  4671                                                                              CB ILE 641                                                                               51.806                                                                             52.098                                                                             61.187                                                                             1.00                                                                              19.28            1DLC4795                    ATOM  4672                                                                              CG1                                                                               ILE 641                                                                               50.490                                                                             52.443                                                                             60.484                                                                             1.00                                                                              16.97            1DLC4796                    ATOM  4673                                                                              CG2                                                                               ILE 641                                                                               52.994                                                                             52.823                                                                             60.536                                                                             1.00                                                                              16.12            1DLC4797                    ATOM  4674                                                                              CD1                                                                               ILE 641                                                                               50.125                                                                             53.890                                                                             60.562                                                                             1.00                                                                              20.58            1DLC4798                    ATOM  4675                                                                              N  PRO 642                                                                               54.270                                                                             49.611                                                                             61.084                                                                             1.00                                                                              21.02            1DLC4799                    ATOM  4676                                                                              CA PRO 642                                                                               55.590                                                                             49.252                                                                             61.616                                                                             1.00                                                                              22.98            1DLC4800                    ATOM  4677                                                                              C  PRO 642                                                                               56.315                                                                             50.542                                                                             61.966                                                                             1.00                                                                              24.81            1DLC4801                    ATOM  4678                                                                              O  PRO 642                                                                               56.451                                                                             51.442                                                                             61.131                                                                             1.00                                                                              29.36            1DLC4802                    ATOM  4679                                                                              CB PRO 642                                                                               56.237                                                                             48.499                                                                             60.453                                                                             1.00                                                                              20.26            1DLC4803                    ATOM  4680                                                                              CG PRO 642                                                                               55.532                                                                             49.048                                                                             59.237                                                                             1.00                                                                              23.90            1DLC4804                    ATOM  4681                                                                              CD PRO 642                                                                               54.113                                                                             49.142                                                                             59.697                                                                             1.00                                                                              21.85            1DLC4805                    ATOM  4682                                                                              N  VAL 643                                                                               56.741                                                                             50.647                                                                             63.216                                                                             1.00                                                                              27.45            1DLC4806                    ATOM  4683                                                                              CA VAL 643                                                                               57.389                                                                             51.859                                                                             63.694                                                                             1.00                                                                              31.83            1DLC4807                    ATOM  4684                                                                              C  VAL 643                                                                               58.701                                                                             51.581                                                                             64.435                                                                             1.00                                                                              36.92            1DLC4808                    ATOM  4685                                                                              O  VAL 643                                                                               58.839                                                                             50.545                                                                             65.083                                                                             1.00                                                                              41.24            1DLC4809                    ATOM  4686                                                                              CB VAL 643                                                                               56.372                                                                             52.642                                                                             64.579                                                                             1.00                                                                              29.35            1DLC4810                    ATOM  4687                                                                              CG1                                                                               VAL 643                                                                               56.972                                                                             53.075                                                                             65.901                                                                             1.00                                                                              25.64            1DLC4811                    ATOM  4688                                                                              CG2                                                                               VAL 643                                                                               55.810                                                                             53.807                                                                             63.806                                                                             1.00                                                                              21.99            1DLC4812                    ATOM  4689                                                                              N  ASN 644                                                                               59.668                                                                             52.487                                                                             64.301                                                                             1.00                                                                              41.01            1DLC4813                    ATOM  4690                                                                              CA ASN 644                                                                               60.962                                                                             52.336                                                                             64.973                                                                             1.00                                                                              46.63            1DLC4814                    ATOM  4691                                                                              C  ASN 644                                                                               60.972                                                                             52.790                                                                             66.436                                                                             1.00                                                                              49.51            1DLC4815                    ATOM  4692                                                                              O  ASN 644                                                                               60.080                                                                             53.575                                                                             66.835                                                                             1.00                                                                              52.85            1DLC4816                    ATOM  4693                                                                              CB ASN 644                                                                               62.067                                                                             53.061                                                                             64.204                                                                             1.00                                                                              45.33            1DLC4817                    ATOM  4694                                                                              CG ASN 644                                                                               62.467                                                                             52.332                                                                             62.940                                                                             1.00                                                                              48.91            1DLC4818                    ATOM  4695                                                                              OD1                                                                               ASN 644                                                                               62.868                                                                             52.952                                                                             61.955                                                                             1.00                                                                              51.43            1DLC4819                    ATOM  4696                                                                              ND2                                                                               ASN 644                                                                               62.365                                                                             51.008                                                                             62.957                                                                             1.00                                                                              48.98            1DLC4820                    ATOM  4697                                                                              OXT                                                                               ASN 644                                                                               61.887                                                                             52.354                                                                             67.174                                                                             1.00                                                                              54.29            1DLC4821                    TER   4698  ASN 644                                1DLC4822                    HETATM                                                                               4699                                                                              O  HOH 1  28.158                                                                             56.658                                                                             35.558                                                                             1.00                                                                              15.93            1DLC4823                    HETATM                                                                               4700                                                                              O  HOH 2  30.007                                                                             42.529                                                                             51.310                                                                             1.00                                                                              29.97            1DLC4824                    HETATM                                                                               4701                                                                              O  HOH 3  36.424                                                                             37.532                                                                             49.700                                                                             1.00                                                                              18.65            1DLC4825                    HETATM                                                                               4702                                                                              O  HOH 4  37.001                                                                             54.392                                                                             48.062                                                                             1.00                                                                              10.97            1DLC4826                    HETATM                                                                               4703                                                                              O  HOH 5  41.124                                                                             51.393                                                                             35.747                                                                             1.00                                                                              18.84            1DLC4827                    HETATM                                                                               4704                                                                              O  HOH 6  39.377                                                                             60.985                                                                             65.970                                                                             1.00                                                                              19.48            1DLC4828                    HETATM                                                                               4705                                                                              O  HOH 7  26.260                                                                             28.918                                                                             41.587                                                                             1.00                                                                              14.99            1DLC4829                    HETATM                                                                               4706                                                                              O  HOH 8  33.639                                                                             33.867                                                                             54.596                                                                             1.00                                                                              15.88            1DLC4830                    HETATM                                                                               4707                                                                              O  HOH 9  51.981                                                                             45.967                                                                             59.702                                                                             1.00                                                                              20.77            1DLC4831                    HETATM                                                                               4708                                                                              O  HOH 10 49.865                                                                             76.628                                                                             42.176                                                                             1.00                                                                              46.98            1DLC4832                    HETATM                                                                               4709                                                                              O  HOH 11 56.250                                                                             42.866                                                                             68.444                                                                             1.00                                                                              32.76            1DLC4833                    HETATM                                                                               4710                                                                              O  HOH 12 48.128                                                                             58.353                                                                             60.425                                                                             1.00                                                                              13.12            1DLC4834                    HETATM                                                                               4711                                                                              O  HOH 13 39.909                                                                             31.847                                                                             39.167                                                                             1.00                                                                              22.65            1DLC4835                    HETATM                                                                               4712                                                                              O  HOH 14 42.525                                                                             40.309                                                                             74.464                                                                             1.00                                                                              21.75            1DLC4836                    HETATM                                                                               4713                                                                              O  HOH 15 35.320                                                                             44.237                                                                             58.596                                                                             1.00                                                                              20.02            1DLC4837                    HETATM                                                                               4714                                                                              O  HOH 16 42.939                                                                             58.321                                                                             46.818                                                                             1.00                                                                              20.43            1DLC4838                    HETATM                                                                               4715                                                                              O  HOH 17 34.791                                                                             45.871                                                                             55.097                                                                             1.00                                                                              17.61            1DLC4839                    HETATM                                                                               4716                                                                              O  HOH 18 59.791                                                                             70.818                                                                             25.850                                                                             1.00                                                                              58.06            1DLC4840                    HETATM                                                                               4717                                                                              O  HOH 19 49.421                                                                             53.503                                                                             45.093                                                                             1.00                                                                              28.93            1DLC4841                    HETATM                                                                               4718                                                                              O  HOH 20 26.124                                                                             35.366                                                                             50.587                                                                             1.00                                                                              20.75            1DLC4842                    HETATM                                                                               4719                                                                              O  HOH 21 22.215                                                                             55.259                                                                             63.293                                                                             1.00                                                                              55.44            1DLC4843                    HETATM                                                                               4720                                                                              O  HOH 22 29.336                                                                             36.466                                                                             34.470                                                                             1.00                                                                              28.07            1DLC4844                    HETATM                                                                               4721                                                                              O  HOH 23 36.856                                                                             28.647                                                                             51.651                                                                             1.00                                                                              25.28            1DLC4845                    HETATM                                                                               4722                                                                              O  HOH 24 32.887                                                                             40.556                                                                             54.227                                                                             1.00                                                                              18.71            1DLC4846                    HETATM                                                                               4723                                                                              O  HOH 25 11.473                                                                             29.145                                                                             36.339                                                                             1.00                                                                              30.31            1DLC4847                    HETATM                                                                               4724                                                                              O  HOH 26 29.975                                                                             51.053                                                                             31.090                                                                             1.00                                                                              24.69            1DLC4848                    HETATM                                                                               4725                                                                              O  HOH 27 23.211                                                                             34.799                                                                             38.939                                                                             1.00                                                                              18.55            1DLC4849                    HETATM                                                                               4726                                                                              O  HOH 28 40.839                                                                             35.888                                                                             64.000                                                                             1.00                                                                              20.47            1DLC4850                    HETATM                                                                               4727                                                                              O  HOH 29 48.014                                                                             63.906                                                                             44.198                                                                             1.00                                                                              20.94            1DLC4851                    HETATM                                                                               4728                                                                              O  HOH 30 38.825                                                                             30.321                                                                             41.019                                                                             1.00                                                                              17.31            1DLC4852                    HETATM                                                                               4729                                                                              O  HOH 31 43.802                                                                             60.051                                                                             66.555                                                                             1.00                                                                              21.11            1DLC4853                    HETATM                                                                               4730                                                                              O  HOH 32 38.144                                                                             26.579                                                                             49.130                                                                             1.00                                                                              19.35            1DLC4854                    HETATM                                                                               4731                                                                              O  HOH 33 38.268                                                                             41.944                                                                             41.244                                                                             1.00                                                                              29.87            1DLC4855                    HETATM                                                                               4732                                                                              O  HOH 34 37.512                                                                             21.444                                                                             38.474                                                                             1.00                                                                              24.99            1DLC4856                    HETATM                                                                               4733                                                                              O  HOH 35 32.702                                                                             36.732                                                                             53.626                                                                             1.00                                                                              20.86            1DLC4857                    HETATM                                                                               4734                                                                              O  HOH 36 49.899                                                                             63.801                                                                             28.431                                                                             1.00                                                                              28.04            1DLC4858                    HETATM                                                                               4735                                                                              O  HOH 37 49.371                                                                             53.132                                                                             68.181                                                                             1.00                                                                              26.75            1DLC4859                    HETATM                                                                               4736                                                                              O  HOH 38 29.606                                                                             38.319                                                                             55.430                                                                             1.00                                                                              25.89            1DLC4860                    HETATM                                                                               4737                                                                              O  HOH 39 41.950                                                                             72.970                                                                             42.722                                                                             1.00                                                                              27.25            1DLC4861                    HETATM                                                                               4738                                                                              O  HOH 40 39.554                                                                             70.091                                                                             45.032                                                                             1.00                                                                              44.51            1DLC4862                    HETATM                                                                               4739                                                                              O  HOH 41 43.093                                                                             57.590                                                                             52.155                                                                             1.00                                                                              22.06            1DLC4863                    HETATM                                                                               4740                                                                              O  HOH 42 36.402                                                                             31.325                                                                             52.356                                                                             1.00                                                                              14.91            1DLC4864                    HETATM                                                                               4741                                                                              O  HOH 43 42.564                                                                             71.403                                                                             44.910                                                                             1.00                                                                              26.89            1DLC4865                    HETATM                                                                               4742                                                                              O  HOH 44 31.202                                                                             36.895                                                                             36.508                                                                             1.00                                                                              20.87            1DLC4866                    HETATM                                                                               4743                                                                              O  HOH 45 9.974                                                                              36.335                                                                             44.772                                                                             1.00                                                                              23.38            1DLC4867                    HETATM                                                                               4744                                                                              O  HOH 46 17.109                                                                             18.398                                                                             39.762                                                                             1.00                                                                              24.03            1DLC4868                    HETATM                                                                               4745                                                                              O  HOH 47 26.895                                                                             37.648                                                                             43.823                                                                             1.00                                                                              21.28            1DLC4869                    HETATM                                                                               4746                                                                              O  HOH 48 19.711                                                                             22.004                                                                             38.604                                                                             1.00                                                                              24.53            1DLC4870                    HETATM                                                                               4747                                                                              O  HOH 49 37.262                                                                             44.313                                                                             53.204                                                                             1.00                                                                              43.74            1DLC4871                    HETATM                                                                               4748                                                                              O  HOH 50 33.936                                                                             47.399                                                                             47.859                                                                             1.00                                                                              22.31            1DLC4872                    HETATM                                                                               4749                                                                              O  HOH 51 30.403                                                                             46.461                                                                             72.142                                                                             1.00                                                                              32.70            1DLC4873                    HETATM                                                                               4750                                                                              O  HOH 52 46.001                                                                             19.419                                                                             46.812                                                                             1.00                                                                              40.72            1DLC4874                    HETATM                                                                               4751                                                                              O  HOH 53 45.816                                                                             40.175                                                                             53.356                                                                             1.00                                                                              25.45            1DLC4875                    HETATM                                                                               4752                                                                              O  HOH 54 30.264                                                                             60.779                                                                             51.534                                                                             1.00                                                                              25.95            1DLC4876                    HETATM                                                                               4753                                                                              O  HOH 55 10.154                                                                             28.983                                                                             45.206                                                                             1.00                                                                              22.19            1DLC4877                    HETATM                                                                               4754                                                                              O  HOH 56 28.704                                                                             26.404                                                                             57.946                                                                             1.00                                                                              26.44            1DLC4878                    HETATM                                                                               4755                                                                              O  HOH 57 32.699                                                                             38.030                                                                             55.930                                                                             1.00                                                                              23.26            1DLC4879                    HETATM                                                                               4756                                                                              O  HOH 58 14.955                                                                             11.719                                                                             28.113                                                                             1.00                                                                              48.40            1DLC4880                    HETATM                                                                               4757                                                                              O  HOH 59 18.793                                                                             41.375                                                                             48.389                                                                             1.00                                                                              46.53            1DLC4881                    HETATM                                                                               4758                                                                              O  HOH 60 36.654                                                                             53.190                                                                             50.493                                                                             1.00                                                                              27.58            1DLC4882                    HETATM                                                                               4759                                                                              O  HOH 61 41.276                                                                             73.788                                                                             36.658                                                                             1.00                                                                              32.95            1DLC4883                    HETATM                                                                               4760                                                                              O  HOH 62 47.841                                                                             44.305                                                                             49.214                                                                             1.00                                                                              32.69            1DLC4884                    HETATM                                                                               4761                                                                              O  HOH 63 35.489                                                                             33.715                                                                             61.967                                                                             1.00                                                                              28.50            1DLC4885                    HETATM                                                                               4762                                                                              O  HOH 64 56.538                                                                             77.886                                                                             37.982                                                                             1.00                                                                              50.68            1DLC4886                    HETATM                                                                               4763                                                                              O  HOH 65 18.717                                                                             10.880                                                                             30.116                                                                             1.00                                                                              45.47            1DLC4887                    HETATM                                                                               4764                                                                              O  HOH 66 36.692                                                                             51.483                                                                             75.590                                                                             1.00                                                                              36.31            1DLC4888                    HETATM                                                                               4765                                                                              O  HOH 67 20.585                                                                             18.690                                                                             41.004                                                                             1.00                                                                              34.39            1DLC4889                    HETATM                                                                               4766                                                                              O  HOH 68 40.508                                                                             40.198                                                                             41.474                                                                             1.00                                                                              39.41            1DLC4890                    HETATM                                                                               4767                                                                              O  HOH 69 39.908                                                                             45.560                                                                             74.947                                                                             1.00                                                                              33.34            1DLC4891                    HETATM                                                                               4768                                                                              O  HOH 70 14.617                                                                             25.579                                                                             48.494                                                                             1.00                                                                              25.51            1DLC4892                    HETATM                                                                               4769                                                                              O  HOH 71 46.860                                                                             64.590                                                                             54.372                                                                             1.00                                                                              34.61            1DLC4893                    HETATM                                                                               4770                                                                              O  HOH 72 38.042                                                                             46.135                                                                             38.081                                                                             1.00                                                                              30.46            1DLC4894                    HETATM                                                                               4771                                                                              O  HOH 73 14.223                                                                             18.604                                                                             37.526                                                                             1.00                                                                              33.61            1DLC4895                    HETATM                                                                               4772                                                                              O  HOH 74 41.396                                                                             33.509                                                                             59.099                                                                             1.00                                                                              33.96            1DLC4896                    HETATM                                                                               4773                                                                              O  HOH 75 36.159                                                                             56.059                                                                             54.037                                                                             1.00                                                                              29.86            1DLC4897                    HETATM                                                                               4774                                                                              O  HOH 76 25.313                                                                             32.849                                                                             50.116                                                                             1.00                                                                              32.15            1DLC4898                    HETATM                                                                               4775                                                                              O  HOH 77 11.778                                                                             10.641                                                                             30.101                                                                             1.00                                                                              44.03            1DLC4899                    HETATM                                                                               4776                                                                              O  HOH 78 42.893                                                                             28.299                                                                             64.966                                                                             1.00                                                                              47.47            1DLC4900                    HETATM                                                                               4777                                                                              O  HOH 79 46.675                                                                             54.242                                                                             75.812                                                                             1.00                                                                              38.86            1DLC4901                    HETATM                                                                               4778                                                                              O  HOH 80 45.755                                                                             41.679                                                                             55.898                                                                             1.00                                                                              34.63            1DLC4902                    HETATM                                                                               4779                                                                              O  HOH 81 25.484                                                                             44.446                                                                             46.854                                                                             1.00                                                                              35.35            1DLC4903                    HETATM                                                                               4780                                                                              O  HOH 82 15.402                                                                             8.669                                                                              44.437                                                                             1.00                                                                              51.05            1DLC4904                    HETATM                                                                               4781                                                                              O  HOH 83 29.189                                                                             60.967                                                                             26.317                                                                             1.00                                                                              41.92            1DLC4905                    HETATM                                                                               4782                                                                              O  HOH 84 28.869                                                                             40.731                                                                             48.778                                                                             1.00                                                                              51.15            1DLC4906                    HETATM                                                                               4783                                                                              O  HOH 85 45.082                                                                             38.563                                                                             44.823                                                                             1.00                                                                              33.55            1DLC4907                    HETATM                                                                               4784                                                                              O  HOH 86 1.705                                                                              23.575                                                                             29.683                                                                             1.00                                                                              48.74            1DLC4908                    HETATM                                                                               4785                                                                              O  HOH 87 27.621                                                                             39.569                                                                             70.673                                                                             1.00                                                                              40.98            1DLC4909                    HETATM                                                                               4786                                                                              O  HOH 88 26.008                                                                             29.161                                                                             48.418                                                                             1.00                                                                              29.63            1DLC4910                    HETATM                                                                               4787                                                                              O  HOH 89 25.317                                                                             11.429                                                                             47.522                                                                             1.00                                                                              27.37            1DLC4911                    HETATM                                                                               4788                                                                              O  HOH 90 30.222                                                                             33.188                                                                             52.083                                                                             1.00                                                                              37.13            1DLC4912                    HETATM                                                                               4789                                                                              O  HOH 91 38.198                                                                             20.113                                                                             36.178                                                                             1.00                                                                              61.28            1DLC4913                    HETATM                                                                               4790                                                                              O  HOH 92 36.499                                                                             29.557                                                                             39.290                                                                             1.00                                                                              29.56            1DLC4914                    HETATM                                                                               4791                                                                              O  HOH 93 19.705                                                                             36.665                                                                             52.735                                                                             1.00                                                                              35.61            1DLC4915                    HETATM                                                                               4792                                                                              O  HOH 94 26.886                                                                             41.897                                                                             52.319                                                                             1.00                                                                              48.74            1DLC4916                    HETATM                                                                               4793                                                                              O  HOH 95 44.038                                                                             20.253                                                                             40.363                                                                             1.00                                                                              39.20            1DLC4917                    HETATM                                                                               4794                                                                              O  HOH 96 31.519                                                                             47.240                                                                             51.443                                                                             1.00                                                                              28.48            1DLC4918                    HETATM                                                                               4795                                                                              O  HOH 97 29.028                                                                             35.445                                                                             61.838                                                                             1.00                                                                              35.57            1DLC4919                    HETATM                                                                               4796                                                                              O  HOH 98 14.327                                                                             29.302                                                                             33.611                                                                             1.00                                                                              41.11            1DLC4920                    HETATM                                                                               4797                                                                              O  HOH 99 19.576                                                                             61.182                                                                             35.587                                                                             1.00                                                                              45.66            1DLC4921                    HETATM                                                                               4798                                                                              O  HOH 100                                                                               56.227                                                                             72.862                                                                             32.221                                                                             1.00                                                                              54.49            1DLC4922                    HETATM                                                                               4799                                                                              O  HOH 101                                                                               15.572                                                                             41.260                                                                             36.469                                                                             1.00                                                                              34.12            1DLC4923                    HETATM                                                                               4800                                                                              O  HOH 102                                                                               46.292                                                                             25.845                                                                             33.724                                                                             1.00                                                                              52.88            1DLC4924                    HETATM                                                                               4801                                                                              O  HOH 103                                                                               32.306                                                                             63.512                                                                             40.031                                                                             1.00                                                                              53.52            1DLC4925                    HETATM                                                                               4802                                                                              O  HOH 104                                                                               34.104                                                                             44.558                                                                             47.227                                                                             1.00                                                                              32.41            1DLC4926                    HETATM                                                                               4803                                                                              O  HOH 105                                                                               44.964                                                                             39.206                                                                             57.270                                                                             1.00                                                                              43.16            1DLC4927                    HETATM                                                                               4804                                                                              O  HOH 106                                                                               56.545                                                                             54.651                                                                             60.410                                                                             1.00                                                                              56.15            1DLC4928                    MASTER   63  2   0   0   0   0   0   6   4803                                                                              1 0 45 1DLC4929                    END                                                1DLC4930                                                                       1DLC4930                    __________________________________________________________________________

All of the compositions and methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. While the compositions and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the compositions and methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain agents which are both chemically and physiologically related may be substituted for the agents described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.

    __________________________________________________________________________     #             SEQUENCE LISTING                                                 - (1) GENERAL INFORMATION:                                                     -    (iii) NUMBER OF SEQUENCES: 113                                            - (2) INFORMATION FOR SEQ ID NO:1:                                             -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1:                                  - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA TTT CA - #C CAT TCT CGT CGT TCT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Phe Hi - #s His Ser Arg Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:2:                                             -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2:                                  - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Phe Hi - #s His Ser Arg Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:3:                                             -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3:                                  - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTC CTT AGT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Leu Ser Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:4:                                             -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4:                                  - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Leu Ser Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:5:                                             -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5:                                  - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT CCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Pro Glu            #   220                                                                        - GAT GTT GCT GAA TTC AGT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Ser His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:6:                                             -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6:                                  - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Pro Glu          #   220                                                                        - Asp Val Ala Glu Phe Ser His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:7:                                             -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7:                                  - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTC TAT CGT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr Arg Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:8:                                             -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8:                                  - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr Arg Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:9:                                             -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9:                                  - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTC TAT AAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr Asn Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - TCT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Ser Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:10:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr Asn Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Ser Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:11:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTC TAT ACC AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr Thr Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:12:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr Thr Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:13:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT AAT TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Asn Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:14:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Asn Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:15:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TTA CTT ACT ACG CT - #T CAG AAG TAC GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Leu Leu Thr Thr Le - #u Gln Lys Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:16:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Leu Leu Thr Thr Le - #u Gln Lys Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:17:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT ACC CTT AAT ACA CT - #A CAG AAG TGC GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Thr Leu Asn Thr Le - #u Gln Lys Cys Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:18:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Thr Leu Asn Thr Le - #u Gln Lys Cys Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:19:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT GCC GTT AAT ACT CT - #G TGG GAA TAC GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ala Val Asn Thr Le - #u Trp Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:20:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ala Val Asn Thr Le - #u Trp Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:21:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTC TAT CGT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr Arg Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TTA CTT ACT ACG CT - #T CAG AAG TAC GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Leu Leu Thr Thr Le - #u Gln Lys Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:22:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr Arg Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Leu Leu Thr Thr Le - #u Gln Lys Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:23:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT ACG CCA ACC ACC CT - #A CAG GAT TAC GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Thr Pro Thr Thr Le - #u Gln Asp Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:24:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Thr Pro Thr Thr Le - #u Gln Asp Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:25:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT GCC CTG AAT ACC TT - #A GAC GAG TAC GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ala Leu Asn Thr Le - #u Asp Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:26:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ala Leu Asn Thr Le - #u Asp Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:27:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAC GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ACT AGG CGA TTC AGA AAG GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Thr Arg Arg Phe Arg Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:28:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Thr Arg Arg Phe Arg Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:29:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTC TAT CGT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr Arg Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TTA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Leu Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:30:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:30:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr Arg Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Leu Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:31:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT ATC CTC AAT ACG CT - #A CAG GAG TAC GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ile Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:32:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ile Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:33:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT ATC CTA CAT ACG CT - #G CAG GAG TAC GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ile Leu His Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:34:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ile Leu His Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:35:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:35:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCC CTC GTT AAC CT - #A ATG GTG TAC GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Val Asn Le - #u Met Val Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:36:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Val Asn Le - #u Met Val Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:37:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCT CTT AGG ACA CC - #A CTT GCG TAC GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Arg Thr Pr - #o Leu Ala Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:38:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Arg Thr Pr - #o Leu Ala Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:39:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TTC AAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Phe Asn            #       285                                                                    - ATT TTG CTT TAC AGT AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Leu Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:40:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:40:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Phe Asn          #       285                                                                    - Ile Leu Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:41:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT GTG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Val Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:42:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Val Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:43:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GGT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:44:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:45:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:45:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AAT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Asn            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - CCA CAC AGC CAA GGT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Pro His Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:46:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Asn          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Pro His Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:47:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - GTT CGG TTA TAC CCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Val Arg Leu Tyr Pro Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:48:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Val Arg Leu Tyr Pro Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:49:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AAT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Asn            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - CCA CAC AGC CAA GGT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Pro His Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - GTT CGG TTA TAC CCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Val Arg Leu Tyr Pro Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:50:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:50:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Asn          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Pro His Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Val Arg Leu Tyr Pro Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:51:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1956 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1953                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAA GAC CCA TGG AA - #G GCT TTT ATG GCA CAA           336                                                                           Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Ly - #s Ala Phe Met Ala Gln            #           110                                                                - GTT GAA GTA CTG ATA GAT AAG AAA ATA GAG GA - #G TAT GCT AAA AGT AAA           384                                                                           Val Glu Val Leu Ile Asp Lys Lys Ile Glu Gl - #u Tyr Ala Lys Ser Lys            #       125                                                                    - GCT CTT GCA GAG TTA CAG GGT CTT CAA AAT AA - #T TTC GAA GAT TAT GTT           432                                                                           Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn As - #n Phe Glu Asp Tyr Val            #   140                                                                        - AAT GCG TTA AAT TCC TGG AAG AAA ACA CCT TT - #A AGT TTG CGA AGT AAA           480                                                                           Asn Ala Leu Asn Ser Trp Lys Lys Thr Pro Le - #u Ser Leu Arg Ser Lys            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AGA AGC CAA GAT CGA ATA AGG GAA CTT TTT TC - #T CAA GCA GAA AGT CAT           528                                                                           Arg Ser Gln Asp Arg Ile Arg Glu Leu Phe Se - #r Gln Ala Glu Ser His            #               175                                                            - TTT CGT AAT TCC ATG CCG TCA TTT GCA GTT TC - #C AAA TTC GAA GTG CTG           576                                                                           Phe Arg Asn Ser Met Pro Ser Phe Ala Val Se - #r Lys Phe Glu Val Leu            #           190                                                                - TTT CTA CCA ACA TAT GCA CAA GCT GCA AAT AC - #A CAT TTA TTG CTA TTA           624                                                                           Phe Leu Pro Thr Tyr Ala Gln Ala Ala Asn Th - #r His Leu Leu Leu Leu            #       205                                                                    - AAA GAT GCT CAA GTT TTT GGA GAA GAA TGG GG - #A TAT TCT TCA GAA GAT           672                                                                           Lys Asp Ala Gln Val Phe Gly Glu Glu Trp Gl - #y Tyr Ser Ser Glu Asp            #   220                                                                        - GTT GCT GAA TTT TAT CAT AGA CAA TTA AAA CT - #T ACA CAA CAA TAC ACT           720                                                                           Val Ala Glu Phe Tyr His Arg Gln Leu Lys Le - #u Thr Gln Gln Tyr Thr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - GAC CAT TGT GTT AAT TGG TAT AAT GTT GGA TT - #A AAT GGT TTA AGA GGT           768                                                                           Asp His Cys Val Asn Trp Tyr Asn Val Gly Le - #u Asn Gly Leu Arg Gly            #               255                                                            - TCA ACT TAT GAT GCA TGG GTC AAA TTT AAC CG - #T TTT CGC AGA GAA ATG           816                                                                           Ser Thr Tyr Asp Ala Trp Val Lys Phe Asn Ar - #g Phe Arg Arg Glu Met            #           270                                                                - ACT TTA ACT GTA TTA GAT CTA ATT GTA CTT TT - #C CCA TTT TAT GAT ATT           864                                                                           Thr Leu Thr Val Leu Asp Leu Ile Val Leu Ph - #e Pro Phe Tyr Asp Ile            #       285                                                                    - CGG TTA TAC TCA AAA GGG GTT AAA ACA GAA CT - #A ACA AGA GAC ATT TTT           912                                                                           Arg Leu Tyr Ser Lys Gly Val Lys Thr Glu Le - #u Thr Arg Asp Ile Phe            #   300                                                                        - ACG GAT CCA ATT TTT TCA CTT AAT ACT CTT CA - #G GAG TAT GGA CCA ACT           960                                                                           Thr Asp Pro Ile Phe Ser Leu Asn Thr Leu Gl - #n Glu Tyr Gly Pro Thr            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - TTT TTG AGT ATA GAA AAC TCT ATT CGA AAA CC - #T CAT TTA TTT GAT TAT          1008                                                                           Phe Leu Ser Ile Glu Asn Ser Ile Arg Lys Pr - #o His Leu Phe Asp Tyr            #               335                                                            - TTA CAG GGG ATT GAA TTT CAT ACG CGT CTT CA - #A CCT GGT TAC TTT GGG          1056                                                                           Leu Gln Gly Ile Glu Phe His Thr Arg Leu Gl - #n Pro Gly Tyr Phe Gly            #           350                                                                - AAA GAT TCT TTC AAT TAT TGG TCT GGT AAT TA - #T GTA GAA ACT AGA CCT          1104                                                                           Lys Asp Ser Phe Asn Tyr Trp Ser Gly Asn Ty - #r Val Glu Thr Arg Pro            #       365                                                                    - AGT ATA GGA TCT AGT AAG ACA ATT ACT TCC CC - #A TTT TAT GGA GAT AAA          1152                                                                           Ser Ile Gly Ser Ser Lys Thr Ile Thr Ser Pr - #o Phe Tyr Gly Asp Lys            #   380                                                                        - TCT ACT GAA CCT GTA CAA AAG CTA AGC TTT GA - #T GGA CAA AAA GTT TAT          1200                                                                           Ser Thr Glu Pro Val Gln Lys Leu Ser Phe As - #p Gly Gln Lys Val Tyr            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - CGA ACT ATA GCT AAT ACA GAC GTA GCG GCT TG - #G CCG AAT GGT AAG GTA          1248                                                                           Arg Thr Ile Ala Asn Thr Asp Val Ala Ala Tr - #p Pro Asn Gly Lys Val            #               415                                                            - TAT TTA GGT GTT ACG AAA GTT GAT TTT AGT CA - #A TAT GAT GAT CAA AAA          1296                                                                           Tyr Leu Gly Val Thr Lys Val Asp Phe Ser Gl - #n Tyr Asp Asp Gln Lys            #           430                                                                - AAT GAA ACT AGT ACA CAA ACA TAT GAT TCA AA - #A AGA AAC AAT GGC CAT          1344                                                                           Asn Glu Thr Ser Thr Gln Thr Tyr Asp Ser Ly - #s Arg Asn Asn Gly His            #       445                                                                    - GTA AGT GCA CAG GAT TCT ATT GAC CAA TTA CC - #G CCA GAA ACA ACA GAT          1392                                                                           Val Ser Ala Gln Asp Ser Ile Asp Gln Leu Pr - #o Pro Glu Thr Thr Asp            #   460                                                                        - GAA CCA CTT GAA AAA GCA TAT AGT CAT CAG CT - #T AAT TAC GCG GAA TGT          1440                                                                           Glu Pro Leu Glu Lys Ala Tyr Ser His Gln Le - #u Asn Tyr Ala Glu Cys            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TTC TTA ATG CAG GAC CGT CGT GGA ACA ATT CC - #A TTT TTT ACT TGG ACA          1488                                                                           Phe Leu Met Gln Asp Arg Arg Gly Thr Ile Pr - #o Phe Phe Thr Trp Thr            #               495                                                            - CAT AGA AGT GTA GAC TTT TTT AAT ACA ATT GA - #T GCT GAA AAG ATT ACT          1536                                                                           His Arg Ser Val Asp Phe Phe Asn Thr Ile As - #p Ala Glu Lys Ile Thr            #           510                                                                - CAA CTT CCA GTA GTG AAA GCA TAT GCC TTG TC - #T TCA GGT GCT TCC ATT          1584                                                                           Gln Leu Pro Val Val Lys Ala Tyr Ala Leu Se - #r Ser Gly Ala Ser Ile            #       525                                                                    - ATT GAA GGT CCA GGA TTC ACA GGA GGA AAT TT - #A CTA TTC CTA AAA GAA          1632                                                                           Ile Glu Gly Pro Gly Phe Thr Gly Gly Asn Le - #u Leu Phe Leu Lys Glu            #   540                                                                        - TCT AGT AAT TCA ATT GCT AAA TTT AAA GTT AC - #A TTA AAT TCA GCA GCC          1680                                                                           Ser Ser Asn Ser Ile Ala Lys Phe Lys Val Th - #r Leu Asn Ser Ala Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - TTG TTA CAA CGA TAT CGT GTA AGA ATA CGC TA - #T GCT TCT ACC ACT AAC          1728                                                                           Leu Leu Gln Arg Tyr Arg Val Arg Ile Arg Ty - #r Ala Ser Thr Thr Asn            #               575                                                            - TTA CGA CTT TTT GTG CAA AAT TCA AAC AAT GA - #T TTT CTT GTC ATC TAC          1776                                                                           Leu Arg Leu Phe Val Gln Asn Ser Asn Asn As - #p Phe Leu Val Ile Tyr            #           590                                                                - ATT AAT AAA ACT ATG AAT AAA GAT GAT GAT TT - #A ACA TAT CAA ACA TTT          1824                                                                           Ile Asn Lys Thr Met Asn Lys Asp Asp Asp Le - #u Thr Tyr Gln Thr Phe            #       605                                                                    - GAT CTC GCA ACT ACT AAT TCT AAT ATG GGG TT - #C TCG GGT GAT AAG AAT          1872                                                                           Asp Leu Ala Thr Thr Asn Ser Asn Met Gly Ph - #e Ser Gly Asp Lys Asn            #   620                                                                        - GAA CTT ATA ATA GGA GCA GAA TCT TTC GTT TC - #T AAT GAA AAA ATC TAT          1920                                                                           Glu Leu Ile Ile Gly Ala Glu Ser Phe Val Se - #r Asn Glu Lys Ile Tyr            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #     1956AAG ATA GAA TTT ATC CCA GTA CAA TT - #G TAA                          Ile Asp Lys Ile Glu Phe Ile Pro Val Gln Le - #u                                #               650                                                            - (2) INFORMATION FOR SEQ ID NO:52:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 651 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Ly - #s Ala Phe Met Ala Gln          #           110                                                                - Val Glu Val Leu Ile Asp Lys Lys Ile Glu Gl - #u Tyr Ala Lys Ser Lys          #       125                                                                    - Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn As - #n Phe Glu Asp Tyr Val          #   140                                                                        - Asn Ala Leu Asn Ser Trp Lys Lys Thr Pro Le - #u Ser Leu Arg Ser Lys          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Arg Ser Gln Asp Arg Ile Arg Glu Leu Phe Se - #r Gln Ala Glu Ser His          #               175                                                            - Phe Arg Asn Ser Met Pro Ser Phe Ala Val Se - #r Lys Phe Glu Val Leu          #           190                                                                - Phe Leu Pro Thr Tyr Ala Gln Ala Ala Asn Th - #r His Leu Leu Leu Leu          #       205                                                                    - Lys Asp Ala Gln Val Phe Gly Glu Glu Trp Gl - #y Tyr Ser Ser Glu Asp          #   220                                                                        - Val Ala Glu Phe Tyr His Arg Gln Leu Lys Le - #u Thr Gln Gln Tyr Thr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Asp His Cys Val Asn Trp Tyr Asn Val Gly Le - #u Asn Gly Leu Arg Gly          #               255                                                            - Ser Thr Tyr Asp Ala Trp Val Lys Phe Asn Ar - #g Phe Arg Arg Glu Met          #           270                                                                - Thr Leu Thr Val Leu Asp Leu Ile Val Leu Ph - #e Pro Phe Tyr Asp Ile          #       285                                                                    - Arg Leu Tyr Ser Lys Gly Val Lys Thr Glu Le - #u Thr Arg Asp Ile Phe          #   300                                                                        - Thr Asp Pro Ile Phe Ser Leu Asn Thr Leu Gl - #n Glu Tyr Gly Pro Thr          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Phe Leu Ser Ile Glu Asn Ser Ile Arg Lys Pr - #o His Leu Phe Asp Tyr          #               335                                                            - Leu Gln Gly Ile Glu Phe His Thr Arg Leu Gl - #n Pro Gly Tyr Phe Gly          #           350                                                                - Lys Asp Ser Phe Asn Tyr Trp Ser Gly Asn Ty - #r Val Glu Thr Arg Pro          #       365                                                                    - Ser Ile Gly Ser Ser Lys Thr Ile Thr Ser Pr - #o Phe Tyr Gly Asp Lys          #   380                                                                        - Ser Thr Glu Pro Val Gln Lys Leu Ser Phe As - #p Gly Gln Lys Val Tyr          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Arg Thr Ile Ala Asn Thr Asp Val Ala Ala Tr - #p Pro Asn Gly Lys Val          #               415                                                            - Tyr Leu Gly Val Thr Lys Val Asp Phe Ser Gl - #n Tyr Asp Asp Gln Lys          #           430                                                                - Asn Glu Thr Ser Thr Gln Thr Tyr Asp Ser Ly - #s Arg Asn Asn Gly His          #       445                                                                    - Val Ser Ala Gln Asp Ser Ile Asp Gln Leu Pr - #o Pro Glu Thr Thr Asp          #   460                                                                        - Glu Pro Leu Glu Lys Ala Tyr Ser His Gln Le - #u Asn Tyr Ala Glu Cys          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Phe Leu Met Gln Asp Arg Arg Gly Thr Ile Pr - #o Phe Phe Thr Trp Thr          #               495                                                            - His Arg Ser Val Asp Phe Phe Asn Thr Ile As - #p Ala Glu Lys Ile Thr          #           510                                                                - Gln Leu Pro Val Val Lys Ala Tyr Ala Leu Se - #r Ser Gly Ala Ser Ile          #       525                                                                    - Ile Glu Gly Pro Gly Phe Thr Gly Gly Asn Le - #u Leu Phe Leu Lys Glu          #   540                                                                        - Ser Ser Asn Ser Ile Ala Lys Phe Lys Val Th - #r Leu Asn Ser Ala Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Leu Leu Gln Arg Tyr Arg Val Arg Ile Arg Ty - #r Ala Ser Thr Thr Asn          #               575                                                            - Leu Arg Leu Phe Val Gln Asn Ser Asn Asn As - #p Phe Leu Val Ile Tyr          #           590                                                                - Ile Asn Lys Thr Met Asn Lys Asp Asp Asp Le - #u Thr Tyr Gln Thr Phe          #       605                                                                    - Asp Leu Ala Thr Thr Asn Ser Asn Met Gly Ph - #e Ser Gly Asp Lys Asn          #   620                                                                        - Glu Leu Ile Ile Gly Ala Glu Ser Phe Val Se - #r Asn Glu Lys Ile Tyr          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Ile Asp Lys Ile Glu Phe Ile Pro Val Gln Le - #u                              #               650                                                            - (2) INFORMATION FOR SEQ ID NO:53:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC GGA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Gly Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:54:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:54:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Gly Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:55:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1956 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1953                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:55:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAA GAC CCA TGG AA - #G GCT TTT ATG GCA CAA           336                                                                           Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Ly - #s Ala Phe Met Ala Gln            #           110                                                                - GTT GAA GTA CTG ATA GAT AAG AAA ATA GAG GA - #G TAT GCT AAA AGT AAA           384                                                                           Val Glu Val Leu Ile Asp Lys Lys Ile Glu Gl - #u Tyr Ala Lys Ser Lys            #       125                                                                    - GCT CTT GCA GAG TTA CAG GGT CTT CAA AAT AA - #T TTC GAA GAT TAT GTT           432                                                                           Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn As - #n Phe Glu Asp Tyr Val            #   140                                                                        - AAT GCG TTA AAT TCC TGG AAG AAA ACA CCT TT - #A AGT TTG CGA AAT CCA           480                                                                           Asn Ala Leu Asn Ser Trp Lys Lys Thr Pro Le - #u Ser Leu Arg Asn Pro            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - CAC AGC CAA GGT CGA ATA AGG GAA CTT TTT TC - #T CAA GCA GAA AGT CAT           528                                                                           His Ser Gln Gly Arg Ile Arg Glu Leu Phe Se - #r Gln Ala Glu Ser His            #               175                                                            - TTT CGT AAT TCC ATG CCG TCA TTT GCA GTT TC - #C AAA TTC GAA GTG CTG           576                                                                           Phe Arg Asn Ser Met Pro Ser Phe Ala Val Se - #r Lys Phe Glu Val Leu            #           190                                                                - TTT CTA CCA ACA TAT GCA CAA GCT GCA AAT AC - #A CAT TTA TTG CTA TTA           624                                                                           Phe Leu Pro Thr Tyr Ala Gln Ala Ala Asn Th - #r His Leu Leu Leu Leu            #       205                                                                    - AAA GAT GCT CAA GTT TTT GGA GAA GAA TGG GG - #A TAT TCT TCA GAA GAT           672                                                                           Lys Asp Ala Gln Val Phe Gly Glu Glu Trp Gl - #y Tyr Ser Ser Glu Asp            #   220                                                                        - GTT GCT GAA TTT TAT CAT AGA CAA TTA AAA CT - #T ACA CAA CAA TAC ACT           720                                                                           Val Ala Glu Phe Tyr His Arg Gln Leu Lys Le - #u Thr Gln Gln Tyr Thr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - GAC CAT TGT GTT AAT TGG TAT AAT GTT GGA TT - #A AAT GGT TTA AGA GGT           768                                                                           Asp His Cys Val Asn Trp Tyr Asn Val Gly Le - #u Asn Gly Leu Arg Gly            #               255                                                            - TCA ACT TAT GAT GCA TGG GTC AAA TTT AAC CG - #T TTT CGC AGA GAA ATG           816                                                                           Ser Thr Tyr Asp Ala Trp Val Lys Phe Asn Ar - #g Phe Arg Arg Glu Met            #           270                                                                - ACT TTA ACT GTA TTA GAT CTA ATT GTA CTT TT - #C CCA TTT TAT GAT ATT           864                                                                           Thr Leu Thr Val Leu Asp Leu Ile Val Leu Ph - #e Pro Phe Tyr Asp Ile            #       285                                                                    - CGG TTA TAC TCA AAA GGG GTT AAA ACA GAA CT - #A ACA AGA GAC ATT TTT           912                                                                           Arg Leu Tyr Ser Lys Gly Val Lys Thr Glu Le - #u Thr Arg Asp Ile Phe            #   300                                                                        - ACG GAT CCA ATT TTT TCA CTT AAT ACT CTT CA - #G GAG TAT GGA CCA ACT           960                                                                           Thr Asp Pro Ile Phe Ser Leu Asn Thr Leu Gl - #n Glu Tyr Gly Pro Thr            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - TTT TTG AGT ATA GAA AAC TCT ATT CGA AAA CC - #T CAT TTA TTT GAT TAT          1008                                                                           Phe Leu Ser Ile Glu Asn Ser Ile Arg Lys Pr - #o His Leu Phe Asp Tyr            #               335                                                            - TTA CAG GGG ATT GAA TTT CAT ACG CGT CTT CA - #A CCT GGT TAC TTT GGG          1056                                                                           Leu Gln Gly Ile Glu Phe His Thr Arg Leu Gl - #n Pro Gly Tyr Phe Gly            #           350                                                                - AAA GAT TCT TTC AAT TAT TGG TCT GGT AAT TA - #T GTA GAA ACT AGA CCT          1104                                                                           Lys Asp Ser Phe Asn Tyr Trp Ser Gly Asn Ty - #r Val Glu Thr Arg Pro            #       365                                                                    - AGT ATA GGA TCT AGT AAG ACA ATT ACT TCC CC - #A TTT TAT GGA GAT AAA          1152                                                                           Ser Ile Gly Ser Ser Lys Thr Ile Thr Ser Pr - #o Phe Tyr Gly Asp Lys            #   380                                                                        - TCT ACT GAA CCT GTA CAA AAG CTA AGC TTT GA - #T GGA CAA AAA GTT TAT          1200                                                                           Ser Thr Glu Pro Val Gln Lys Leu Ser Phe As - #p Gly Gln Lys Val Tyr            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - CGA ACT ATA GCT AAT ACA GAC GTA GCG GCT TG - #G CCG AAT GGT AAG GTA          1248                                                                           Arg Thr Ile Ala Asn Thr Asp Val Ala Ala Tr - #p Pro Asn Gly Lys Val            #               415                                                            - TAT TTA GGT GTT ACG AAA GTT GAT TTT AGT CA - #A TAT GAT GAT CAA AAA          1296                                                                           Tyr Leu Gly Val Thr Lys Val Asp Phe Ser Gl - #n Tyr Asp Asp Gln Lys            #           430                                                                - AAT GAA ACT AGT ACA CAA ACA TAT GAT TCA AA - #A AGA AAC AAT GGC CAT          1344                                                                           Asn Glu Thr Ser Thr Gln Thr Tyr Asp Ser Ly - #s Arg Asn Asn Gly His            #       445                                                                    - GTA AGT GCA CAG GAT TCT ATT GAC CAA TTA CC - #G CCA GAA ACA ACA GAT          1392                                                                           Val Ser Ala Gln Asp Ser Ile Asp Gln Leu Pr - #o Pro Glu Thr Thr Asp            #   460                                                                        - GAA CCA CTT GAA AAA GCA TAT AGT CAT CAG CT - #T AAT TAC GCG GAA TGT          1440                                                                           Glu Pro Leu Glu Lys Ala Tyr Ser His Gln Le - #u Asn Tyr Ala Glu Cys            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TTC TTA ATG CAG GAC CGT CGT GGA ACA ATT CC - #A TTT TTT ACT TGG ACA          1488                                                                           Phe Leu Met Gln Asp Arg Arg Gly Thr Ile Pr - #o Phe Phe Thr Trp Thr            #               495                                                            - CAT AGA AGT GTA GAC TTT TTT AAT ACA ATT GA - #T GCT GAA AAG ATT ACT          1536                                                                           His Arg Ser Val Asp Phe Phe Asn Thr Ile As - #p Ala Glu Lys Ile Thr            #           510                                                                - CAA CTT CCA GTA GTG AAA GCA TAT GCC TTG TC - #T TCA GGT GCT TCC ATT          1584                                                                           Gln Leu Pro Val Val Lys Ala Tyr Ala Leu Se - #r Ser Gly Ala Ser Ile            #       525                                                                    - ATT GAA GGT CCA GGA TTC ACA GGA GGA AAT TT - #A CTA TTC CTA AAA GAA          1632                                                                           Ile Glu Gly Pro Gly Phe Thr Gly Gly Asn Le - #u Leu Phe Leu Lys Glu            #   540                                                                        - TCT AGT AAT TCA ATT GCT AAA TTT AAA GTT AC - #A TTA AAT TCA GCA GCC          1680                                                                           Ser Ser Asn Ser Ile Ala Lys Phe Lys Val Th - #r Leu Asn Ser Ala Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - TTG TTA CAA CGA TAT CGT GTA AGA ATA CGC TA - #T GCT TCT ACC ACT AAC          1728                                                                           Leu Leu Gln Arg Tyr Arg Val Arg Ile Arg Ty - #r Ala Ser Thr Thr Asn            #               575                                                            - TTA CGA CTT TTT GTG CAA AAT TCA AAC AAT GA - #T TTT CTT GTC ATC TAC          1776                                                                           Leu Arg Leu Phe Val Gln Asn Ser Asn Asn As - #p Phe Leu Val Ile Tyr            #           590                                                                - ATT AAT AAA ACT ATG AAT AAA GAT GAT GAT TT - #A ACA TAT CAA ACA TTT          1824                                                                           Ile Asn Lys Thr Met Asn Lys Asp Asp Asp Le - #u Thr Tyr Gln Thr Phe            #       605                                                                    - GAT CTC GCA ACT ACT AAT TCT AAT ATG GGG TT - #C TCG GGT GAT AAG AAT          1872                                                                           Asp Leu Ala Thr Thr Asn Ser Asn Met Gly Ph - #e Ser Gly Asp Lys Asn            #   620                                                                        - GAA CTT ATA ATA GGA GCA GAA TCT TTC GTT TC - #T AAT GAA AAA ATC TAT          1920                                                                           Glu Leu Ile Ile Gly Ala Glu Ser Phe Val Se - #r Asn Glu Lys Ile Tyr            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #     1956AAG ATA GAA TTT ATC CCA GTA CAA TT - #G TAA                          Ile Asp Lys Ile Glu Phe Ile Pro Val Gln Le - #u                                #               650                                                            - (2) INFORMATION FOR SEQ ID NO:56:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 651 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:56:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Ly - #s Ala Phe Met Ala Gln          #           110                                                                - Val Glu Val Leu Ile Asp Lys Lys Ile Glu Gl - #u Tyr Ala Lys Ser Lys          #       125                                                                    - Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn As - #n Phe Glu Asp Tyr Val          #   140                                                                        - Asn Ala Leu Asn Ser Trp Lys Lys Thr Pro Le - #u Ser Leu Arg Asn Pro          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - His Ser Gln Gly Arg Ile Arg Glu Leu Phe Se - #r Gln Ala Glu Ser His          #               175                                                            - Phe Arg Asn Ser Met Pro Ser Phe Ala Val Se - #r Lys Phe Glu Val Leu          #           190                                                                - Phe Leu Pro Thr Tyr Ala Gln Ala Ala Asn Th - #r His Leu Leu Leu Leu          #       205                                                                    - Lys Asp Ala Gln Val Phe Gly Glu Glu Trp Gl - #y Tyr Ser Ser Glu Asp          #   220                                                                        - Val Ala Glu Phe Tyr His Arg Gln Leu Lys Le - #u Thr Gln Gln Tyr Thr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Asp His Cys Val Asn Trp Tyr Asn Val Gly Le - #u Asn Gly Leu Arg Gly          #               255                                                            - Ser Thr Tyr Asp Ala Trp Val Lys Phe Asn Ar - #g Phe Arg Arg Glu Met          #           270                                                                - Thr Leu Thr Val Leu Asp Leu Ile Val Leu Ph - #e Pro Phe Tyr Asp Ile          #       285                                                                    - Arg Leu Tyr Ser Lys Gly Val Lys Thr Glu Le - #u Thr Arg Asp Ile Phe          #   300                                                                        - Thr Asp Pro Ile Phe Ser Leu Asn Thr Leu Gl - #n Glu Tyr Gly Pro Thr          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Phe Leu Ser Ile Glu Asn Ser Ile Arg Lys Pr - #o His Leu Phe Asp Tyr          #               335                                                            - Leu Gln Gly Ile Glu Phe His Thr Arg Leu Gl - #n Pro Gly Tyr Phe Gly          #           350                                                                - Lys Asp Ser Phe Asn Tyr Trp Ser Gly Asn Ty - #r Val Glu Thr Arg Pro          #       365                                                                    - Ser Ile Gly Ser Ser Lys Thr Ile Thr Ser Pr - #o Phe Tyr Gly Asp Lys          #   380                                                                        - Ser Thr Glu Pro Val Gln Lys Leu Ser Phe As - #p Gly Gln Lys Val Tyr          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Arg Thr Ile Ala Asn Thr Asp Val Ala Ala Tr - #p Pro Asn Gly Lys Val          #               415                                                            - Tyr Leu Gly Val Thr Lys Val Asp Phe Ser Gl - #n Tyr Asp Asp Gln Lys          #           430                                                                - Asn Glu Thr Ser Thr Gln Thr Tyr Asp Ser Ly - #s Arg Asn Asn Gly His          #       445                                                                    - Val Ser Ala Gln Asp Ser Ile Asp Gln Leu Pr - #o Pro Glu Thr Thr Asp          #   460                                                                        - Glu Pro Leu Glu Lys Ala Tyr Ser His Gln Le - #u Asn Tyr Ala Glu Cys          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Phe Leu Met Gln Asp Arg Arg Gly Thr Ile Pr - #o Phe Phe Thr Trp Thr          #               495                                                            - His Arg Ser Val Asp Phe Phe Asn Thr Ile As - #p Ala Glu Lys Ile Thr          #           510                                                                - Gln Leu Pro Val Val Lys Ala Tyr Ala Leu Se - #r Ser Gly Ala Ser Ile          #       525                                                                    - Ile Glu Gly Pro Gly Phe Thr Gly Gly Asn Le - #u Leu Phe Leu Lys Glu          #   540                                                                        - Ser Ser Asn Ser Ile Ala Lys Phe Lys Val Th - #r Leu Asn Ser Ala Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Leu Leu Gln Arg Tyr Arg Val Arg Ile Arg Ty - #r Ala Ser Thr Thr Asn          #               575                                                            - Leu Arg Leu Phe Val Gln Asn Ser Asn Asn As - #p Phe Leu Val Ile Tyr          #           590                                                                - Ile Asn Lys Thr Met Asn Lys Asp Asp Asp Le - #u Thr Tyr Gln Thr Phe          #       605                                                                    - Asp Leu Ala Thr Thr Asn Ser Asn Met Gly Ph - #e Ser Gly Asp Lys Asn          #   620                                                                        - Glu Leu Ile Ile Gly Ala Glu Ser Phe Val Se - #r Asn Glu Lys Ile Tyr          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Ile Asp Lys Ile Glu Phe Ile Pro Val Gln Le - #u                              #               650                                                            - (2) INFORMATION FOR SEQ ID NO:57:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1956 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1953                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAA GAC CCA TGG AA - #G GCT TTT ATG GCA CAA           336                                                                           Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Ly - #s Ala Phe Met Ala Gln            #           110                                                                - GTT GAA GTA CTG ATA GAT AAG AAA ATA GAG GA - #G TAT GCT AAA AGT AAA           384                                                                           Val Glu Val Leu Ile Asp Lys Lys Ile Glu Gl - #u Tyr Ala Lys Ser Lys            #       125                                                                    - GCT CTT GCA GAG TTA CAG GGT CTT CAA AAT AA - #T TTC GAA GAT TAT GTT           432                                                                           Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn As - #n Phe Glu Asp Tyr Val            #   140                                                                        - AAT GCG TTA AAT TCC TGG AAG AAA TTT CAC CA - #T TCT CGT CGT TCT AAA           480                                                                           Asn Ala Leu Asn Ser Trp Lys Lys Phe His Hi - #s Ser Arg Arg Ser Lys            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AGA AGC CAA GAT CGA ATA AGG GAA CTT TTT TC - #T CAA GCA GAA AGT CAT           528                                                                           Arg Ser Gln Asp Arg Ile Arg Glu Leu Phe Se - #r Gln Ala Glu Ser His            #               175                                                            - TTT CGT AAT TCC ATG CCG TCA TTT GCA GTT TC - #C AAA TTC GAA GTG CTG           576                                                                           Phe Arg Asn Ser Met Pro Ser Phe Ala Val Se - #r Lys Phe Glu Val Leu            #           190                                                                - TTT CTA CCA ACA TAT GCA CAA GCT GCA AAT AC - #A CAT TTA TTG CTA TTA           624                                                                           Phe Leu Pro Thr Tyr Ala Gln Ala Ala Asn Th - #r His Leu Leu Leu Leu            #       205                                                                    - AAA GAT GCT CAA GTT TTT GGA GAA GAA TGG GG - #A TAT TCT TCA GAA GAT           672                                                                           Lys Asp Ala Gln Val Phe Gly Glu Glu Trp Gl - #y Tyr Ser Ser Glu Asp            #   220                                                                        - GTT GCT GAA TTT TAT CAT AGA CAA TTA AAA CT - #T ACA CAA CAA TAC ACT           720                                                                           Val Ala Glu Phe Tyr His Arg Gln Leu Lys Le - #u Thr Gln Gln Tyr Thr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - GAC CAT TGT GTT AAT TGG TAT AAT GTT GGA TT - #A AAT GGT TTA AGA GGT           768                                                                           Asp His Cys Val Asn Trp Tyr Asn Val Gly Le - #u Asn Gly Leu Arg Gly            #               255                                                            - TCA ACT TAT GAT GCA TGG GTC AAA TTT AAC CG - #T TTT CGC AGA GAA ATG           816                                                                           Ser Thr Tyr Asp Ala Trp Val Lys Phe Asn Ar - #g Phe Arg Arg Glu Met            #           270                                                                - ACT TTA ACT GTA TTA GAT CTA ATT GTA CTT TT - #C CCA TTT TAT GAT ATT           864                                                                           Thr Leu Thr Val Leu Asp Leu Ile Val Leu Ph - #e Pro Phe Tyr Asp Ile            #       285                                                                    - CGG TTA TAC TCA AAA GGG GTT AAA ACA GAA CT - #A ACA AGA GAC ATT TTT           912                                                                           Arg Leu Tyr Ser Lys Gly Val Lys Thr Glu Le - #u Thr Arg Asp Ile Phe            #   300                                                                        - ACG GAT CCA ATT TTT TCA CTT AAT ACT CTT CA - #G GAG TAT GGA CCA ACT           960                                                                           Thr Asp Pro Ile Phe Ser Leu Asn Thr Leu Gl - #n Glu Tyr Gly Pro Thr            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - TTT TTG AGT ATA GAA AAC TCT ATT CGA AAA CC - #T CAT TTA TTT GAT TAT          1008                                                                           Phe Leu Ser Ile Glu Asn Ser Ile Arg Lys Pr - #o His Leu Phe Asp Tyr            #               335                                                            - TTA CAG GGG ATT GAA TTT CAT ACG CGT CTT CA - #A CCT GGT TAC TTT GGG          1056                                                                           Leu Gln Gly Ile Glu Phe His Thr Arg Leu Gl - #n Pro Gly Tyr Phe Gly            #           350                                                                - AAA GAT TCT TTC AAT TAT TGG TCT GGT AAT TA - #T GTA GAA ACT AGA CCT          1104                                                                           Lys Asp Ser Phe Asn Tyr Trp Ser Gly Asn Ty - #r Val Glu Thr Arg Pro            #       365                                                                    - AGT ATA GGA TCT AGT AAG ACA ATT ACT TCC CC - #A TTT TAT GGA GAT AAA          1152                                                                           Ser Ile Gly Ser Ser Lys Thr Ile Thr Ser Pr - #o Phe Tyr Gly Asp Lys            #   380                                                                        - TCT ACT GAA CCT GTA CAA AAG CTA AGC TTT GA - #T GGA CAA AAA GTT TAT          1200                                                                           Ser Thr Glu Pro Val Gln Lys Leu Ser Phe As - #p Gly Gln Lys Val Tyr            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - CGA ACT ATA GCT AAT ACA GAC GTA GCG GCT TG - #G CCG AAT GGT AAG GTA          1248                                                                           Arg Thr Ile Ala Asn Thr Asp Val Ala Ala Tr - #p Pro Asn Gly Lys Val            #               415                                                            - TAT TTA GGT GTT ACG AAA GTT GAT TTT AGT CA - #A TAT GAT GAT CAA AAA          1296                                                                           Tyr Leu Gly Val Thr Lys Val Asp Phe Ser Gl - #n Tyr Asp Asp Gln Lys            #           430                                                                - AAT GAA ACT AGT ACA CAA ACA TAT GAT TCA AA - #A AGA AAC AAT GGC CAT          1344                                                                           Asn Glu Thr Ser Thr Gln Thr Tyr Asp Ser Ly - #s Arg Asn Asn Gly His            #       445                                                                    - GTA AGT GCA CAG GAT TCT ATT GAC CAA TTA CC - #G CCA GAA ACA ACA GAT          1392                                                                           Val Ser Ala Gln Asp Ser Ile Asp Gln Leu Pr - #o Pro Glu Thr Thr Asp            #   460                                                                        - GAA CCA CTT GAA AAA GCA TAT AGT CAT CAG CT - #T AAT TAC GCG GAA TGT          1440                                                                           Glu Pro Leu Glu Lys Ala Tyr Ser His Gln Le - #u Asn Tyr Ala Glu Cys            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TTC TTA ATG CAG GAC CGT CGT GGA ACA ATT CC - #A TTT TTT ACT TGG ACA          1488                                                                           Phe Leu Met Gln Asp Arg Arg Gly Thr Ile Pr - #o Phe Phe Thr Trp Thr            #               495                                                            - CAT AGA AGT GTA GAC TTT TTT AAT ACA ATT GA - #T GCT GAA AAG ATT ACT          1536                                                                           His Arg Ser Val Asp Phe Phe Asn Thr Ile As - #p Ala Glu Lys Ile Thr            #           510                                                                - CAA CTT CCA GTA GTG AAA GCA TAT GCC TTG TC - #T TCA GGT GCT TCC ATT          1584                                                                           Gln Leu Pro Val Val Lys Ala Tyr Ala Leu Se - #r Ser Gly Ala Ser Ile            #       525                                                                    - ATT GAA GGT CCA GGA TTC ACA GGA GGA AAT TT - #A CTA TTC CTA AAA GAA          1632                                                                           Ile Glu Gly Pro Gly Phe Thr Gly Gly Asn Le - #u Leu Phe Leu Lys Glu            #   540                                                                        - TCT AGT AAT TCA ATT GCT AAA TTT AAA GTT AC - #A TTA AAT TCA GCA GCC          1680                                                                           Ser Ser Asn Ser Ile Ala Lys Phe Lys Val Th - #r Leu Asn Ser Ala Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - TTG TTA CAA CGA TAT CGT GTA AGA ATA CGC TA - #T GCT TCT ACC ACT AAC          1728                                                                           Leu Leu Gln Arg Tyr Arg Val Arg Ile Arg Ty - #r Ala Ser Thr Thr Asn            #               575                                                            - TTA CGA CTT TTT GTG CAA AAT TCA AAC AAT GA - #T TTT CTT GTC ATC TAC          1776                                                                           Leu Arg Leu Phe Val Gln Asn Ser Asn Asn As - #p Phe Leu Val Ile Tyr            #           590                                                                - ATT AAT AAA ACT ATG AAT AAA GAT GAT GAT TT - #A ACA TAT CAA ACA TTT          1824                                                                           Ile Asn Lys Thr Met Asn Lys Asp Asp Asp Le - #u Thr Tyr Gln Thr Phe            #       605                                                                    - GAT CTC GCA ACT ACT AAT TCT AAT ATG GGG TT - #C TCG GGT GAT AAG AAT          1872                                                                           Asp Leu Ala Thr Thr Asn Ser Asn Met Gly Ph - #e Ser Gly Asp Lys Asn            #   620                                                                        - GAA CTT ATA ATA GGA GCA GAA TCT TTC GTT TC - #T AAT GAA AAA ATC TAT          1920                                                                           Glu Leu Ile Ile Gly Ala Glu Ser Phe Val Se - #r Asn Glu Lys Ile Tyr            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #     1956AAG ATA GAA TTT ATC CCA GTA CAA TT - #G TAA                          Ile Asp Lys Ile Glu Phe Ile Pro Val Gln Le - #u                                #               650                                                            - (2) INFORMATION FOR SEQ ID NO:58:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 651 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:58:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Ly - #s Ala Phe Met Ala Gln          #           110                                                                - Val Glu Val Leu Ile Asp Lys Lys Ile Glu Gl - #u Tyr Ala Lys Ser Lys          #       125                                                                    - Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn As - #n Phe Glu Asp Tyr Val          #   140                                                                        - Asn Ala Leu Asn Ser Trp Lys Lys Phe His Hi - #s Ser Arg Arg Ser Lys          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Arg Ser Gln Asp Arg Ile Arg Glu Leu Phe Se - #r Gln Ala Glu Ser His          #               175                                                            - Phe Arg Asn Ser Met Pro Ser Phe Ala Val Se - #r Lys Phe Glu Val Leu          #           190                                                                - Phe Leu Pro Thr Tyr Ala Gln Ala Ala Asn Th - #r His Leu Leu Leu Leu          #       205                                                                    - Lys Asp Ala Gln Val Phe Gly Glu Glu Trp Gl - #y Tyr Ser Ser Glu Asp          #   220                                                                        - Val Ala Glu Phe Tyr His Arg Gln Leu Lys Le - #u Thr Gln Gln Tyr Thr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Asp His Cys Val Asn Trp Tyr Asn Val Gly Le - #u Asn Gly Leu Arg Gly          #               255                                                            - Ser Thr Tyr Asp Ala Trp Val Lys Phe Asn Ar - #g Phe Arg Arg Glu Met          #           270                                                                - Thr Leu Thr Val Leu Asp Leu Ile Val Leu Ph - #e Pro Phe Tyr Asp Ile          #       285                                                                    - Arg Leu Tyr Ser Lys Gly Val Lys Thr Glu Le - #u Thr Arg Asp Ile Phe          #   300                                                                        - Thr Asp Pro Ile Phe Ser Leu Asn Thr Leu Gl - #n Glu Tyr Gly Pro Thr          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Phe Leu Ser Ile Glu Asn Ser Ile Arg Lys Pr - #o His Leu Phe Asp Tyr          #               335                                                            - Leu Gln Gly Ile Glu Phe His Thr Arg Leu Gl - #n Pro Gly Tyr Phe Gly          #           350                                                                - Lys Asp Ser Phe Asn Tyr Trp Ser Gly Asn Ty - #r Val Glu Thr Arg Pro          #       365                                                                    - Ser Ile Gly Ser Ser Lys Thr Ile Thr Ser Pr - #o Phe Tyr Gly Asp Lys          #   380                                                                        - Ser Thr Glu Pro Val Gln Lys Leu Ser Phe As - #p Gly Gln Lys Val Tyr          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Arg Thr Ile Ala Asn Thr Asp Val Ala Ala Tr - #p Pro Asn Gly Lys Val          #               415                                                            - Tyr Leu Gly Val Thr Lys Val Asp Phe Ser Gl - #n Tyr Asp Asp Gln Lys          #           430                                                                - Asn Glu Thr Ser Thr Gln Thr Tyr Asp Ser Ly - #s Arg Asn Asn Gly His          #       445                                                                    - Val Ser Ala Gln Asp Ser Ile Asp Gln Leu Pr - #o Pro Glu Thr Thr Asp          #   460                                                                        - Glu Pro Leu Glu Lys Ala Tyr Ser His Gln Le - #u Asn Tyr Ala Glu Cys          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Phe Leu Met Gln Asp Arg Arg Gly Thr Ile Pr - #o Phe Phe Thr Trp Thr          #               495                                                            - His Arg Ser Val Asp Phe Phe Asn Thr Ile As - #p Ala Glu Lys Ile Thr          #           510                                                                - Gln Leu Pro Val Val Lys Ala Tyr Ala Leu Se - #r Ser Gly Ala Ser Ile          #       525                                                                    - Ile Glu Gly Pro Gly Phe Thr Gly Gly Asn Le - #u Leu Phe Leu Lys Glu          #   540                                                                        - Ser Ser Asn Ser Ile Ala Lys Phe Lys Val Th - #r Leu Asn Ser Ala Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Leu Leu Gln Arg Tyr Arg Val Arg Ile Arg Ty - #r Ala Ser Thr Thr Asn          #               575                                                            - Leu Arg Leu Phe Val Gln Asn Ser Asn Asn As - #p Phe Leu Val Ile Tyr          #           590                                                                - Ile Asn Lys Thr Met Asn Lys Asp Asp Asp Le - #u Thr Tyr Gln Thr Phe          #       605                                                                    - Asp Leu Ala Thr Thr Asn Ser Asn Met Gly Ph - #e Ser Gly Asp Lys Asn          #   620                                                                        - Glu Leu Ile Ile Gly Ala Glu Ser Phe Val Se - #r Asn Glu Lys Ile Tyr          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Ile Asp Lys Ile Glu Phe Ile Pro Val Gln Le - #u                              #               650                                                            - (2) INFORMATION FOR SEQ ID NO:59:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:59:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GGT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT ACC CTT AAT ACA CT - #A CAG AAG TAC GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Thr Leu Asn Thr Le - #u Gln Lys Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:60:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:60:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Thr Leu Asn Thr Le - #u Gln Lys Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:61:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:61:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GGT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - GTT CGG TTA TAC CCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Val Arg Leu Tyr Pro Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TCT ACG GAT CCA ATT TTT GCC GTT AAT ACT CT - #G TGG GAA TAC GGA CCA           960                                                                           Ser Thr Asp Pro Ile Phe Ala Val Asn Thr Le - #u Trp Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CGA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Arg Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GCA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Ala Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:62:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:62:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Val Arg Leu Tyr Pro Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Ser Thr Asp Pro Ile Phe Ala Val Asn Thr Le - #u Trp Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Arg Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Ala Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:63:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:63:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - GTT CGG TTA TAC CCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Val Arg Leu Tyr Pro Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CGA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Arg Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:64:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:64:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Val Arg Leu Tyr Pro Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Arg Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:65:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:65:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GGT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TTA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Leu Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:66:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:66:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Leu Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:67:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:67:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CGA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Arg Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:68:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:68:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Arg Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:69:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1482 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1479                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:69:                                 - AGT AAA AGA AGC CAA GAT CGA ATA AGG GAA CT - #T TTT TCT CAA GCA GAA            48                                                                           Ser Lys Arg Ser Gln Asp Arg Ile Arg Glu Le - #u Phe Ser Gln Ala Glu            #                 15                                                           - AGT CAT TTT CGT AAT TCC ATG CCG TCA TTT GC - #A GTT TCC AAA TTC GAA            96                                                                           Ser His Phe Arg Asn Ser Met Pro Ser Phe Al - #a Val Ser Lys Phe Glu            #             30                                                               - GTG CTG TTT CTA CCA ACA TAT GCA CAA GCT GC - #A AAT ACA CAT TTA TTG           144                                                                           Val Leu Phe Leu Pro Thr Tyr Ala Gln Ala Al - #a Asn Thr His Leu Leu            #         45                                                                   - CTA TTA AAA GAT GCT CAA GTT TTT GGA GAA GA - #A TGG GGA TAT TCT TCA           192                                                                           Leu Leu Lys Asp Ala Gln Val Phe Gly Glu Gl - #u Trp Gly Tyr Ser Ser            #     60                                                                       - GAA GAT GTT GCT GAA TTT TAT CAT AGA CAA TT - #A AAA CTT ACA CAA CAA           240                                                                           Glu Asp Val Ala Glu Phe Tyr His Arg Gln Le - #u Lys Leu Thr Gln Gln            # 80                                                                           - TAC ACT GAC CAT TGT GTT AAT TGG TAT AAT GT - #T GGA TTA AAT GGT TTA           288                                                                           Tyr Thr Asp His Cys Val Asn Trp Tyr Asn Va - #l Gly Leu Asn Gly Leu            #                 95                                                           - AGA GGT TCA ACT TAT GAT GCA TGG GTC AAA TT - #T AAC CGT TTT CGC AGA           336                                                                           Arg Gly Ser Thr Tyr Asp Ala Trp Val Lys Ph - #e Asn Arg Phe Arg Arg            #           110                                                                - GAA ATG ACT TTA ACT GTA TTA GAT CTA ATT GT - #A CTT TTC CCA TTT TAT           384                                                                           Glu Met Thr Leu Thr Val Leu Asp Leu Ile Va - #l Leu Phe Pro Phe Tyr            #       125                                                                    - GAT ATT CGG TTA TAC TCA AAA GGG GTT AAA AC - #A GAA CTA ACA AGA GAC           432                                                                           Asp Ile Arg Leu Tyr Ser Lys Gly Val Lys Th - #r Glu Leu Thr Arg Asp            #   140                                                                        - ATT TTT ACG GAT CCA ATT TTT TCA CTT AAT AC - #T CTT CAG GAG TAT GGA           480                                                                           Ile Phe Thr Asp Pro Ile Phe Ser Leu Asn Th - #r Leu Gln Glu Tyr Gly            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - CCA ACT TTT TTG AGT ATA GAA AAC TCT ATT CG - #A AAA CCT CAT TTA TTT           528                                                                           Pro Thr Phe Leu Ser Ile Glu Asn Ser Ile Ar - #g Lys Pro His Leu Phe            #               175                                                            - GAT TAT TTA CAG GGG ATT GAA TTT CAT ACG CG - #T CTT CAA CCT GGT TAC           576                                                                           Asp Tyr Leu Gln Gly Ile Glu Phe His Thr Ar - #g Leu Gln Pro Gly Tyr            #           190                                                                - TTT GGG AAA GAT TCT TTC AAT TAT TGG TCT GG - #T AAT TAT GTA GAA ACT           624                                                                           Phe Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gl - #y Asn Tyr Val Glu Thr            #       205                                                                    - AGA CCT AGT ATA GGA TCT AGT AAG ACA ATT AC - #T TCC CCA TTT TAT GGA           672                                                                           Arg Pro Ser Ile Gly Ser Ser Lys Thr Ile Th - #r Ser Pro Phe Tyr Gly            #   220                                                                        - GAT AAA TCT ACT GAA CCT GTA CAA AAG CTA AG - #C TTT GAT GGA CAA AAA           720                                                                           Asp Lys Ser Thr Glu Pro Val Gln Lys Leu Se - #r Phe Asp Gly Gln Lys            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - GTT TAT CGA ACT ATA GCT AAT ACA GAC GTA GC - #G GCT TGG CCG AAT GGT           768                                                                           Val Tyr Arg Thr Ile Ala Asn Thr Asp Val Al - #a Ala Trp Pro Asn Gly            #               255                                                            - AAG GTA TAT TTA GGT GTT ACG AAA GTT GAT TT - #T AGT CAA TAT GAT GAT           816                                                                           Lys Val Tyr Leu Gly Val Thr Lys Val Asp Ph - #e Ser Gln Tyr Asp Asp            #           270                                                                - CAA AAA AAT GAA ACT AGT ACA CAA ACA TAT GA - #T TCA AAA AGA AAC AAT           864                                                                           Gln Lys Asn Glu Thr Ser Thr Gln Thr Tyr As - #p Ser Lys Arg Asn Asn            #       285                                                                    - GGC CAT GTA AGT GCA CAG GAT TCT ATT GAC CA - #A TTA CCG CCA GAA ACA           912                                                                           Gly His Val Ser Ala Gln Asp Ser Ile Asp Gl - #n Leu Pro Pro Glu Thr            #   300                                                                        - ACA GAT GAA CCA CTT GAA AAA GCA TAT AGT CA - #T CAG CTT AAT TAC GCG           960                                                                           Thr Asp Glu Pro Leu Glu Lys Ala Tyr Ser Hi - #s Gln Leu Asn Tyr Ala            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - GAA TGT TTC TTA ATG CAG GAC CGT CGT GGA AC - #A ATT CCA TTT TTT ACT          1008                                                                           Glu Cys Phe Leu Met Gln Asp Arg Arg Gly Th - #r Ile Pro Phe Phe Thr            #               335                                                            - TGG ACA CAT AGA AGT GTA GAC TTT TTT AAT AC - #A ATT GAT GCT GAA AAG          1056                                                                           Trp Thr His Arg Ser Val Asp Phe Phe Asn Th - #r Ile Asp Ala Glu Lys            #           350                                                                - ATT ACT CAA CTT CCA GTA GTG AAA GCA TAT GC - #C TTG TCT TCA GGT GCT          1104                                                                           Ile Thr Gln Leu Pro Val Val Lys Ala Tyr Al - #a Leu Ser Ser Gly Ala            #       365                                                                    - TCC ATT ATT GAA GGT CCA GGA TTC ACA GGA GG - #A AAT TTA CTA TTC CTA          1152                                                                           Ser Ile Ile Glu Gly Pro Gly Phe Thr Gly Gl - #y Asn Leu Leu Phe Leu            #   380                                                                        - AAA GAA TCT AGT AAT TCA ATT GCT AAA TTT AA - #A GTT ACA TTA AAT TCA          1200                                                                           Lys Glu Ser Ser Asn Ser Ile Ala Lys Phe Ly - #s Val Thr Leu Asn Ser            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - GCA GCC TTG TTA CAA CGA TAT CGT GTA AGA AT - #A CGC TAT GCT TCT ACC          1248                                                                           Ala Ala Leu Leu Gln Arg Tyr Arg Val Arg Il - #e Arg Tyr Ala Ser Thr            #               415                                                            - ACT AAC TTA CGA CTT TTT GTG CAA AAT TCA AA - #C AAT GAT TTT CTT GTC          1296                                                                           Thr Asn Leu Arg Leu Phe Val Gln Asn Ser As - #n Asn Asp Phe Leu Val            #           430                                                                - ATC TAC ATT AAT AAA ACT ATG AAT AAA GAT GA - #T GAT TTA ACA TAT CAA          1344                                                                           Ile Tyr Ile Asn Lys Thr Met Asn Lys Asp As - #p Asp Leu Thr Tyr Gln            #       445                                                                    - ACA TTT GAT CTC GCA ACT ACT AAT TCT AAT AT - #G GGG TTC TCG GGT GAT          1392                                                                           Thr Phe Asp Leu Ala Thr Thr Asn Ser Asn Me - #t Gly Phe Ser Gly Asp            #   460                                                                        - AAG AAT GAA CTT ATA ATA GGA GCA GAA TCT TT - #C GTT TCT AAT GAA AAA          1440                                                                           Lys Asn Glu Leu Ile Ile Gly Ala Glu Ser Ph - #e Val Ser Asn Glu Lys            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - ATC TAT ATA GAT AAG ATA GAA TTT ATC CCA GT - #A CAA TTG TAA                  #1482                                                                          Ile Tyr Ile Asp Lys Ile Glu Phe Ile Pro Va - #l Gln Leu                        #               490                                                            - (2) INFORMATION FOR SEQ ID NO:70:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 493 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:70:                                 - Ser Lys Arg Ser Gln Asp Arg Ile Arg Glu Le - #u Phe Ser Gln Ala Glu          #                 15                                                           - Ser His Phe Arg Asn Ser Met Pro Ser Phe Al - #a Val Ser Lys Phe Glu          #             30                                                               - Val Leu Phe Leu Pro Thr Tyr Ala Gln Ala Al - #a Asn Thr His Leu Leu          #         45                                                                   - Leu Leu Lys Asp Ala Gln Val Phe Gly Glu Gl - #u Trp Gly Tyr Ser Ser          #     60                                                                       - Glu Asp Val Ala Glu Phe Tyr His Arg Gln Le - #u Lys Leu Thr Gln Gln          # 80                                                                           - Tyr Thr Asp His Cys Val Asn Trp Tyr Asn Va - #l Gly Leu Asn Gly Leu          #                 95                                                           - Arg Gly Ser Thr Tyr Asp Ala Trp Val Lys Ph - #e Asn Arg Phe Arg Arg          #           110                                                                - Glu Met Thr Leu Thr Val Leu Asp Leu Ile Va - #l Leu Phe Pro Phe Tyr          #       125                                                                    - Asp Ile Arg Leu Tyr Ser Lys Gly Val Lys Th - #r Glu Leu Thr Arg Asp          #   140                                                                        - Ile Phe Thr Asp Pro Ile Phe Ser Leu Asn Th - #r Leu Gln Glu Tyr Gly          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Pro Thr Phe Leu Ser Ile Glu Asn Ser Ile Ar - #g Lys Pro His Leu Phe          #               175                                                            - Asp Tyr Leu Gln Gly Ile Glu Phe His Thr Ar - #g Leu Gln Pro Gly Tyr          #           190                                                                - Phe Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gl - #y Asn Tyr Val Glu Thr          #       205                                                                    - Arg Pro Ser Ile Gly Ser Ser Lys Thr Ile Th - #r Ser Pro Phe Tyr Gly          #   220                                                                        - Asp Lys Ser Thr Glu Pro Val Gln Lys Leu Se - #r Phe Asp Gly Gln Lys          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Val Tyr Arg Thr Ile Ala Asn Thr Asp Val Al - #a Ala Trp Pro Asn Gly          #               255                                                            - Lys Val Tyr Leu Gly Val Thr Lys Val Asp Ph - #e Ser Gln Tyr Asp Asp          #           270                                                                - Gln Lys Asn Glu Thr Ser Thr Gln Thr Tyr As - #p Ser Lys Arg Asn Asn          #       285                                                                    - Gly His Val Ser Ala Gln Asp Ser Ile Asp Gl - #n Leu Pro Pro Glu Thr          #   300                                                                        - Thr Asp Glu Pro Leu Glu Lys Ala Tyr Ser Hi - #s Gln Leu Asn Tyr Ala          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Glu Cys Phe Leu Met Gln Asp Arg Arg Gly Th - #r Ile Pro Phe Phe Thr          #               335                                                            - Trp Thr His Arg Ser Val Asp Phe Phe Asn Th - #r Ile Asp Ala Glu Lys          #           350                                                                - Ile Thr Gln Leu Pro Val Val Lys Ala Tyr Al - #a Leu Ser Ser Gly Ala          #       365                                                                    - Ser Ile Ile Glu Gly Pro Gly Phe Thr Gly Gl - #y Asn Leu Leu Phe Leu          #   380                                                                        - Lys Glu Ser Ser Asn Ser Ile Ala Lys Phe Ly - #s Val Thr Leu Asn Ser          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Ala Ala Leu Leu Gln Arg Tyr Arg Val Arg Il - #e Arg Tyr Ala Ser Thr          #               415                                                            - Thr Asn Leu Arg Leu Phe Val Gln Asn Ser As - #n Asn Asp Phe Leu Val          #           430                                                                - Ile Tyr Ile Asn Lys Thr Met Asn Lys Asp As - #p Asp Leu Thr Tyr Gln          #       445                                                                    - Thr Phe Asp Leu Ala Thr Thr Asn Ser Asn Me - #t Gly Phe Ser Gly Asp          #   460                                                                        - Lys Asn Glu Leu Ile Ile Gly Ala Glu Ser Ph - #e Val Ser Asn Glu Lys          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Ile Tyr Ile Asp Lys Ile Glu Phe Ile Pro Va - #l Gln Leu                      #               490                                                            - (2) INFORMATION FOR SEQ ID NO:71:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 23 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:71:                                 #                23AAAG ATG                                                    - (2) INFORMATION FOR SEQ ID NO:72:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 20 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:72:                                 # 20               AATC                                                        - (2) INFORMATION FOR SEQ ID NO:73:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 39 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 21..23                                                 #/note= "N = A, T, G, C"RMATION:                                               -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:73:                                 #    39            ATTC NNNCATAGAC AATTAAAAC                                   - (2) INFORMATION FOR SEQ ID NO:74:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 34 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 19..21                                                 #/note= "N = A, T, G, C"RMATION:                                               -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:74:                                 #        34        ATNN NAGACAATTA AAAC                                        - (2) INFORMATION FOR SEQ ID NO:75:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 33 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 17                                                     #/note= "N = A, T, C or G"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 18                                                     #/note= "N = T, G, C or A"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 19                                                     #/note= "N = A, T, G or C"ATION:                                               -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:75:                                 #         33       NNNT TATACTCAAA AGG                                         - (2) INFORMATION FOR SEQ ID NO:76:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 64 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 24                                                     #/note= "N = T, G, C or A"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #27, 28, 30, 34, 36, 39, 43)of(25,                                             #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #33, 35, 37, 42, 44)ON: one-of(31,                                             #/note= "N = A, G, C or T"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 40                                                     #/note= "N = A, T, C or G"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #29, 32, 38, 41)CATION: one-of(26,                                             #/note= "N = A, T, G or C"ATION:                                               -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:76:                                 - AGCTATGCTG GTCTCGGAAG AAANNNNNNN NNNNNNNNNN NNNNAAAAGA AG - #CCAAGATC          60                                                                           #             64                                                               - (2) INFORMATION FOR SEQ ID NO:77:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 40 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:77:                                 #    40            CTTC CAGGAATTTA ACGCATTAAC                                  - (2) INFORMATION FOR SEQ ID NO:78:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 65 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #27, 29, 30, 37, 42)ON: one-of(22,                                             #/note= "N = A, G, C or T"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #26, 28, 31, 38, 40, 43, 44)of(23,                                             #/note= "N = T, G, C or A"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #39)      (B) LOCATION: one-of(24,                                             #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #32, 33, 41, 46, 47, 48)one-of(25,                                             #/note= "N = A, T, C or G"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 34                                                     #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 45                                                     #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 35..36                                                 #/note= "N = A, G, C or T"ATION:                                               -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:78:                                 - AGCTATGCTG GTCTCCCATT TNNNNNNNNN NNNNNNNNNN NNNNNNNNGT TA - #AAACAGAA          60                                                                           #            65                                                                - (2) INFORMATION FOR SEQ ID NO:79:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 36 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:79:                                 #       36         AATG GGAAAAGTAC AATTAG                                      - (2) INFORMATION FOR SEQ ID NO:80:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 63 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #27, 31, 36, 44)CATION: one-of(23,                                             #/note= "N = A, G, C or T"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #25, 26, 33, 35, 38)ON: one-of(24,                                             #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #34, 37)  (B) LOCATION: one-of(28,                                             #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #30, 32, 39, 42, 45)ON: one-of(29,                                             #/note= "N = T, G, C or A"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #43)      (B) LOCATION: one-of(40,                                             #/note= "N = A, T, C or G"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 41                                                     #/note= "N = A, C, T or G"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 46                                                     #/note= "N = A, T, G or C"ATION:                                               -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:80:                                 - CATTTTTACG GATCCAATTT TTNNNNNNNN NNNNNNNNNN NNNNNNGGAC CA - #ACTTTTTT          60                                                                           #             63                                                               - (2) INFORMATION FOR SEQ ID NO:81:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 62 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #31, 32, 33, 42)CATION: one-of(28,                                             #/note= "N = A, G, C or T"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #38, 39, 41)) LOCATION: one-of(29,                                             #/note= "N = T, G, C or A"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 30                                                     #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #35, 40)  (B) LOCATION: one-of(34,                                             #/note= "N = A, T, C or G"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 36                                                     #/note= "N = A, T, G, C"RMATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 37                                                     #/note= "N = A, T, G or C"ATION:                                               -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:81:                                 - GAATTTCATA CGCGTCTTCA ACCTGGTNNN NNNNNNNNNN NNTCTTTCAA TT - #ATTGGTCT          60                                                                           #              62                                                              - (2) INFORMATION FOR SEQ ID NO:82:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 73 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #49, 52)  (B) LOCATION: one-of(41,                                             #/note= "N = A, G, C or T"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 42..43                                                 #/note= "N = A, T, C or G"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 44..45                                                 #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 46                                                     #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #48, 53, 54)) LOCATION: one-of(47,                                             #/note= "N = T, G, C or A"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #51, 55)  (B) LOCATION: one-of(50,                                             #/note= "N = A, T, C or G"ATION:                                               -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:82:                                 - AAAAGTTTAT CGAACTATAG CTAATACAGA CGTAGCGGCT NNNNNNNNNN NN - #NNNGTATA          60                                                                           #      73                                                                      - (2) INFORMATION FOR SEQ ID NO:83:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 20 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:83:                                 # 20               GGGC                                                        - (2) INFORMATION FOR SEQ ID NO:84:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 17 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:84:                                 #   17             G                                                           - (2) INFORMATION FOR SEQ ID NO:85:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 32 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:85:                                 #          32      CAAG GTCGAATAAG GG                                          - (2) INFORMATION FOR SEQ ID NO:86:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 43 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:86:                                 # 43               ATCC ACACAGCCAA GGTCGAATAA GGG                              - (2) INFORMATION FOR SEQ ID NO:87:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 35 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:87:                                 #       35         CGGT TATACCCAAA AGGGG                                       - (2) INFORMATION FOR SEQ ID NO:88:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 25 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:88:                                 #               25 ATGG AAGGC                                                  - (2) INFORMATION FOR SEQ ID NO:89:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 22 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:89:                                 #                 22AGT GC                                                     - (2) INFORMATION FOR SEQ ID NO:90:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 17 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:90:                                 #   17             A                                                           - (2) INFORMATION FOR SEQ ID NO:91:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 17 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:91:                                 #   17             A                                                           - (2) INFORMATION FOR SEQ ID NO:92:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 60 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #26, 29)  (B) LOCATION: one-of(22,                                             #/note= "N = T, G, C or A"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #33, 36)  (B) LOCATION: one-of(23,                                             #/note= "N = A, G, C or T"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #27, 28, 32, 35, 37, 38)one-of(24,                                             #/note= "N = A, T, C or G"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #30, 31, 34)) LOCATION: one-of(25,                                             #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 39                                                     #/note= "N = A, T, G or C"ATION:                                               -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:92:                                 - AGCTATGCTG GTCTCTTCTT ANNNNNNNNN NNNNNNNNNA CAATTCCATT TT - #TTACTTGG          60                                                                           - (2) INFORMATION FOR SEQ ID NO:93:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 40 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:93:                                 #    40            AAGA AACAAACCGC GTAATTAAGC                                  - (2) INFORMATION FOR SEQ ID NO:94:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 20 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:94:                                 # 20               ATCC                                                        - (2) INFORMATION FOR SEQ ID NO:95:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 55 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #22, 23, 31)) LOCATION: one-of(19,                                             #/note= "N = A, T, C or G"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #26, 27, 29, 30, 35)ON: one-of(20,                                             #/note= "N = T, G, C or A"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #32, 34)  (B) LOCATION: one-of(21,                                             #/note= "N = A, G, C or T"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                #33)      (B) LOCATION: one-of(24,                                             #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 25                                                     #/note= "N = A, G, T or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 28                                                     #/note= "N = A, T, G or C"ATION:                                               -     (ix) FEATURE:                                                                      (A) NAME/KEY: modified.sub.-- - #base                                          (B) LOCATION: 36                                                     #/note= "N = A, G, C or T"ATION:                                               -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:95:                                 - GTACAAAAGC TAAGCTTTNN NNNNNNNNNN NNNNNNCGAA CTATAGCTAA TA - #CAG               55                                                                           - (2) INFORMATION FOR SEQ ID NO:96:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 7 amino                                                            (B) TYPE: amino acid                                                           (C) STRANDEDNESS:                                                              (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:96:                                 - Ser Lys Arg Ser Gln Asp Arg                                                  1               5                                                              - (2) INFORMATION FOR SEQ ID NO:97:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (ix) FEATURE:                                                                      (A) NAME/KEY: CDS                                                              (B) LOCATION: 1..1956                                                -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:97:                                 - ATG AAT CCA AAC AAT CGA AGT GAA CAT GAT AC - #G ATA AAG GTT ACA CCT            48                                                                           Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro            #                 15                                                           - AAC AGT GAA TTG CAA ACT AAC CAT AAT CAA TA - #T CCT TTA GCT GAC AAT            96                                                                           Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn            #             30                                                               - CCA AAT TCA ACA CTA GAA GAA TTA AAT TAT AA - #A GAA TTT TTA AGA ATG           144                                                                           Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met            #         45                                                                   - ACT GAA GAC AGT TCT ACG GAA GTG CTA GAC AA - #C TCT ACA GTA AAA GAT           192                                                                           Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp            #     60                                                                       - GCA GTT GGG ACA GGA ATT TCT GTT GTA GGG CA - #G ATT TTA GGT GTT GTA           240                                                                           Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val            # 80                                                                           - GGA GTT CCA TTT GCT GGG GCA CTC ACT TCA TT - #T TAT CAA TCA TTT CTT           288                                                                           Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu            #                 95                                                           - AAC ACT ATA TGG CCA AGT GAT GCT GAC CCA TG - #G AAG GCT TTT ATG GCA           336                                                                           Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala            #           110                                                                - CAA GTT GAA GTA CTG ATA GAT AAG AAA ATA GA - #G GAG TAT GCT AAA AGT           384                                                                           Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser            #       125                                                                    - AAA GCT CTT GCA GAG TTA CAG GGT CTT CAA AA - #T AAT TTC GAA GAT TAT           432                                                                           Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr            #   140                                                                        - GTT AAT GCG TTA AAT TCC TGG AAG AAA ACA CC - #T TTA AGT TTG CGA AGT           480                                                                           Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser            145                 1 - #50                 1 - #55                 1 -        #60                                                                            - AAA AGA AGC CAA GAT CGA ATA AGG GAA CTT TT - #T TCT CAA GCA GAA AGT           528                                                                           Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser            #               175                                                            - CAT TTT CGT AAT TCC ATG CCG TCA TTT GCA GT - #T TCC AAA TTC GAA GTG           576                                                                           His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val            #           190                                                                - CTG TTT CTA CCA ACA TAT GCA CAA GCT GCA AA - #T ACA CAT TTA TTG CTA           624                                                                           Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu            #       205                                                                    - TTA AAA GAT GCT CAA GTT TTT GGA GAA GAA TG - #G GGA TAT TCT TCA GAA           672                                                                           Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu            #   220                                                                        - GAT GTT GCT GAA TTT TAT CAT AGA CAA TTA AA - #A CTT ACA CAA CAA TAC           720                                                                           Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr            225                 2 - #30                 2 - #35                 2 -        #40                                                                            - ACT GAC CAT TGT GTT AAT TGG TAT AAT GTT GG - #A TTA AAT GGT TTA AGA           768                                                                           Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg            #               255                                                            - GGT TCA ACT TAT GAT GCA TGG GTC AAA TTT AA - #C CGT TTT CGC AGA GAA           816                                                                           Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu            #           270                                                                - ATG ACT TTA ACT GTA TTA GAT CTA ATT GTA CT - #T TTC CCA TTT TAT GAT           864                                                                           Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp            #       285                                                                    - ATT CGG TTA TAC TCA AAA GGG GTT AAA ACA GA - #A CTA ACA AGA GAC ATT           912                                                                           Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile            #   300                                                                        - TTT ACG GAT CCA ATT TTT TCA CTT AAT ACT CT - #T CAG GAG TAT GGA CCA           960                                                                           Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro            305                 3 - #10                 3 - #15                 3 -        #20                                                                            - ACT TTT TTG AGT ATA GAA AAC TCT ATT CGA AA - #A CCT CAT TTA TTT GAT          1008                                                                           Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp            #               335                                                            - TAT TTA CAG GGG ATT GAA TTT CAT ACG CGT CT - #T CAA CCT GGT TAC TTT          1056                                                                           Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe            #           350                                                                - GGG AAA GAT TCT TTC AAT TAT TGG TCT GGT AA - #T TAT GTA GAA ACT AGA          1104                                                                           Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg            #       365                                                                    - CCT AGT ATA GGA TCT AGT AAG ACA ATT ACT TC - #C CCA TTT TAT GGA GAT          1152                                                                           Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp            #   380                                                                        - AAA TCT ACT GAA CCT GTA CAA AAG CTA AGC TT - #T GAT GGA CAA AAA GTT          1200                                                                           Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val            385                 3 - #90                 3 - #95                 4 -        #00                                                                            - TAT CGA ACT ATA GCT AAT ACA GAC GTA GCG GC - #T TGG CCG AAT GGT AAG          1248                                                                           Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys            #               415                                                            - GTA TAT TTA GGT GTT ACG AAA GTT GAT TTT AG - #T CAA TAT GAT GAT CAA          1296                                                                           Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln            #           430                                                                - AAA AAT GAA ACT AGT ACA CAA ACA TAT GAT TC - #A AAA AGA AAC AAT GGC          1344                                                                           Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly            #       445                                                                    - CAT GTA AGT GCA CAG GAT TCT ATT GAC CAA TT - #A CCG CCA GAA ACA ACA          1392                                                                           His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr            #   460                                                                        - GAT GAA CCA CTT GAA AAA GCA TAT AGT CAT CA - #G CTT AAT TAC GCG GAA          1440                                                                           Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu            465                 4 - #70                 4 - #75                 4 -        #80                                                                            - TGT TTC TTA ATG CAG GAC CGT CGT GGA ACA AT - #T CCA TTT TTT ACT TGG          1488                                                                           Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp            #               495                                                            - ACA CAT AGA AGT GTA GAC TTT TTT AAT ACA AT - #T GAT GCT GAA AAG ATT          1536                                                                           Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile            #           510                                                                - ACT CAA CTT CCA GTA GTG AAA GCA TAT GCC TT - #G TCT TCA GGT GCT TCC          1584                                                                           Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser            #       525                                                                    - ATT ATT GAA GGT CCA GGA TTC ACA GGA GGA AA - #T TTA CTA TTC CTA AAA          1632                                                                           Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys            #   540                                                                        - GAA TCT AGT AAT TCA ATT GCT AAA TTT AAA GT - #T ACA TTA AAT TCA GCA          1680                                                                           Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala            545                 5 - #50                 5 - #55                 5 -        #60                                                                            - GCC TTG TTA CAA CGA TAT CGT GTA AGA ATA CG - #C TAT GCT TCT ACC ACT          1728                                                                           Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr            #               575                                                            - AAC TTA CGA CTT TTT GTG CAA AAT TCA AAC AA - #T GAT TTT CTT GTC ATC          1776                                                                           Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile            #           590                                                                - TAC ATT AAT AAA ACT ATG AAT AAA GAT GAT GA - #T TTA ACA TAT CAA ACA          1824                                                                           Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr            #       605                                                                    - TTT GAT CTC GCA ACT ACT AAT TCT AAT ATG GG - #G TTC TCG GGT GAT AAG          1872                                                                           Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys            #   620                                                                        - AAT GAA CTT ATA ATA GGA GCA GAA TCT TTC GT - #T TCT AAT GAA AAA ATC          1920                                                                           Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile            625                 6 - #30                 6 - #35                 6 -        #40                                                                            #   1959A GAT AAG ATA GAA TTT ATC CCA GTA CA - #A TTG TAA                      Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                            #               650                                                            - (2) INFORMATION FOR SEQ ID NO:98:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (D) TOPOLOGY: linear                                                 -     (ii) MOLECULE TYPE: protein                                              -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:98:                                 - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                 15                                                           - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #             30                                                               - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #         45                                                                   - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #     60                                                                       - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          # 80                                                                           - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                 95                                                           - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:99:                                            -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 2000 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:99:                                 - CCATCCATGG CAAACCCTAA CAATCGTTCC GAACACGACA CCATCAAGGT TA - #CTCCAAAC          60                                                                           - TCTGAGTTGC AAACTAATCA CAACCAGTAC CCATTGGCTG ACAATCCTAA CA - #GTACTCTT         120                                                                           - GAGGAACTTA ACTACAAGGA GTTTCTCCGG ATGACCGAAG ATAGCTCCAC TG - #AGGTTCTC         180                                                                           - GATAACTCTA CAGTGAAGGA CGCTGTTGGA ACTGGCATTA GCGTTGTGGG AC - #AGATTCTT         240                                                                           - GGAGTGGTTG GTGTTCCATT CGCTGGAGCT TTGACCAGCT TCTACCAGTC CT - #TTCTCAAC         300                                                                           - ACCATCTGGC CTTCAGATGC TGATCCCTGG AAGGCTTTCA TGGCCCAAGT GG - #AAGTCTTG         360                                                                           - ATCGATAAGA AGATCGAAGA GTATGCCAAG TCTAAAGCCT TGGCTGAGTT GC - #AAGGTTTG         420                                                                           - CAGAACAACT TCGAGGATTA CGTCAACGCA CTCAACAGCT GGAAGAAAAC TC - #CCTTGAGT         480                                                                           - CTCAGGTCTA AGCGTTCCCA GGACCGTATT CGTGAACTTT TCAGCCAAGC CG - #AATCCCAC         540                                                                           - TTCAGAAACT CCATGCCTAG CTTTGCCGTT TCTAAGTTCG AGGTGCTCTT CT - #TGCCAACA         600                                                                           - TACGCACAAG CTGCCAACAC TCATCTCTTG CTTCTCAAAG ACGCTCAGGT GT - #TTGGTGAG         660                                                                           - GAATGGGGTT ACTCCAGTGA AGATGTTGCC GAGTTCTACC GTAGGCAGCT CA - #AGTTGACT         720                                                                           - CAACAGTACA CAGACCACTG CGTCAACTGG TACAACGTTG GGCTCAATGG TC - #TTAGAGGA         780                                                                           - TCTACCTACG ACGCATGGGT GAAGTTCAAC AGGTTTCGTA GAGAGATGAC CT - #TGACTGTG         840                                                                           - CTCGATCTTA TCGTTCTCTT TCCATTCTAC GACATTCGTC TTTACTCCAA AG - #GCGTTAAG         900                                                                           - ACAGAGCTGA CCAGAGACAT CTTCACCGAT CCCATCTTCC TACTTACGAC CC - #TGCAGAAA         960                                                                           - TACGGTCCAA CTTTTCTCTC CATTGAGAAC AGCATCAGGA AGCCTCACCT CT - #TCGACTAT        1020                                                                           - CTGCAAGGCA TTGAGTTTCA CACCAGGTTG CAACCTGGTT ACTTCGGTAA GG - #ATTCCTTC        1080                                                                           - AACTACTGGA GCGGAAACTA CGTTGAAACC AGACCATCCA TCGGATCTAG CA - #AGACCATC        1140                                                                           - ACTTCTCCAT TCTACGGTGA CAAGAGCACT GAGCCAGTGC AGAAGTTGAG CT - #TCGATGGG        1200                                                                           - CAGAAGGTGT ATAGAACCAT CGCCAATACC GATGTTGCAG CTTGGCCTAA TG - #GCAAGGTC        1260                                                                           - TACCTTGGAG TTACTAAAGT GGACTTCTCC CAATACGACG ATCAGAAGAA CG - #AGACATCT        1320                                                                           - ACTCAAACCT ACGATAGTAA GAGGAACAAT GGCCATGTTT CCGCACAAGA CT - #CCATTGAC        1380                                                                           - CAACTTCCAC CTGAAACCAC TGATGAACCA TTGGAGAAGG CTTACAGTCA CC - #AACTTAAC        1440                                                                           - TACGCCGAAT GCTTTCTCAT GCAAGACAGG CGTGGCACCA TTCCGTTCTT TA - #CATGGACT        1500                                                                           - CACAGGTCTG TCGACTTCTT TAACACTATC GACGCTGAGA AGATTACCCA AC - #TTCCCGTG        1560                                                                           - GTCAAGGCTT ATGCCTTGTC CAGCGGAGCT TCCATCATTG AAGGTCCAGG CT - #TCACCGGT        1620                                                                           - GGCAACTTGC TCTTCCTTAA GGAGTCCAGC AACTCCATCG CCAAGTTCAA AG - #TGACACTT        1680                                                                           - AACTCAGCAG CCTTGCTCCA ACGTTACAGG GTTCGTATCA GATACGCAAG CA - #CTACCAAT        1740                                                                           - CTTCGCCTCT TTGTCCAGAA CAGCAACAAT GATTTCCTTG TCATCTACAT CA - #ACAAGACT        1800                                                                           - ATGAACAAAG ACGATGACCT CACCTACCAA ACATTCGATC TTGCCACTAC CA - #ATAGTAAC        1860                                                                           - ATGGGATTCT CTGGTGACAA GAACGAGCTG ATCATAGGTG CTGAGAGCTT TG - #TCTCTAAT        1920                                                                           - GAGAAGATTT ACATAGACAA GATCGAGTTC ATTCCAGTTC AACTCTAATA GA - #TCCCCCGG        1980                                                                           #                 200 - #0                                                     - (2) INFORMATION FOR SEQ ID NO:100:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 653 amino                                                          (B) TYPE: amino acid                                                           (C) STRANDEDNESS:                                                              (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:100:                                - Met Ala Asn Pro Asn Asn Arg Ser Glu His As - #p Thr Ile Lys Val Thr          #                15                                                            - Pro Asn Ser Glu Leu Gln Thr Asn His Asn Gl - #n Tyr Pro Leu Ala Asp          #            30                                                                - Asn Pro Asn Ser Thr Leu Glu Glu Leu Asn Ty - #r Lys Glu Phe Leu Arg          #        45                                                                    - Met Thr Glu Asp Ser Ser Thr Glu Val Leu As - #p Asn Ser Thr Val Lys          #    60                                                                        - Asp Ala Val Gly Thr Gly Ile Ser Val Val Gl - #y Gln Ile Leu Gly Val          #80                                                                            - Val Gly Val Pro Phe Ala Gly Ala Leu Thr Se - #r Phe Tyr Gln Ser Phe          #                95                                                            - Leu Asn Thr Ile Trp Pro Ser Asp Ala Asp Pr - #o Trp Lys Ala Phe Met          #           110                                                                - Ala Gln Val Glu Val Leu Ile Asp Lys Lys Il - #e Glu Glu Tyr Ala Lys          #       125                                                                    - Ser Lys Ala Leu Ala Glu Leu Gln Gly Leu Gl - #n Asn Asn Phe Glu Asp          #   140                                                                        - Tyr Val Asn Ala Leu Asn Ser Trp Lys Lys Th - #r Pro Leu Ser Leu Arg          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Ser Lys Arg Ser Gln Asp Arg Ile Arg Glu Le - #u Phe Ser Gln Ala Glu          #               175                                                            - Ser His Phe Arg Asn Ser Met Pro Ser Phe Al - #a Val Ser Lys Phe Glu          #           190                                                                - Val Leu Phe Leu Pro Thr Tyr Ala Gln Ala Al - #a Asn Thr His Leu Leu          #       205                                                                    - Leu Leu Lys Asp Ala Gln Val Phe Gly Glu Gl - #u Trp Gly Tyr Ser Ser          #   220                                                                        - Glu Asp Val Ala Glu Phe Tyr Arg Arg Gln Le - #u Lys Leu Thr Gln Gln          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Tyr Thr Asp His Cys Val Asn Trp Tyr Asn Va - #l Gly Leu Asn Gly Leu          #               255                                                            - Arg Gly Ser Thr Tyr Asp Ala Trp Val Lys Ph - #e Asn Arg Phe Arg Arg          #           270                                                                - Glu Met Thr Leu Thr Val Leu Asp Leu Ile Va - #l Leu Phe Pro Phe Tyr          #       285                                                                    - Asp Ile Arg Leu Tyr Ser Lys Gly Val Lys Th - #r Glu Leu Thr Arg Asp          #   300                                                                        - Ile Phe Thr Asp Pro Ile Phe Leu Leu Thr Th - #r Leu Gln Lys Tyr Gly          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Pro Thr Phe Leu Ser Ile Glu Asn Ser Ile Ar - #g Lys Pro His Leu Phe          #               335                                                            - Asp Tyr Leu Gln Gly Ile Glu Phe His Thr Ar - #g Leu Gln Pro Gly Tyr          #           350                                                                - Phe Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gl - #y Asn Tyr Val Glu Thr          #       365                                                                    - Arg Pro Ser Ile Gly Ser Ser Lys Thr Ile Th - #r Ser Pro Phe Tyr Gly          #   380                                                                        - Asp Lys Ser Thr Glu Pro Val Gln Lys Leu Se - #r Phe Asp Gly Gln Lys          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Val Tyr Arg Thr Ile Ala Asn Thr Asp Val Al - #a Ala Trp Pro Asn Gly          #               415                                                            - Lys Val Tyr Leu Gly Val Thr Lys Val Asp Ph - #e Ser Gln Tyr Asp Asp          #           430                                                                - Gln Lys Asn Glu Thr Ser Thr Gln Thr Tyr As - #p Ser Lys Arg Asn Asn          #       445                                                                    - Gly His Val Ser Ala Gln Asp Ser Ile Asp Gl - #n Leu Pro Pro Glu Thr          #   460                                                                        - Thr Asp Glu Pro Leu Glu Lys Ala Tyr Ser Hi - #s Gln Leu Asn Tyr Ala          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Glu Cys Phe Leu Met Gln Asp Arg Arg Gly Th - #r Ile Pro Phe Phe Thr          #               495                                                            - Trp Thr His Arg Ser Val Asp Phe Phe Asn Th - #r Ile Asp Ala Glu Lys          #           510                                                                - Ile Thr Gln Leu Pro Val Val Lys Ala Tyr Al - #a Leu Ser Ser Gly Ala          #       525                                                                    - Ser Ile Ile Glu Gly Pro Gly Phe Thr Gly Gl - #y Asn Leu Leu Phe Leu          #   540                                                                        - Lys Glu Ser Ser Asn Ser Ile Ala Lys Phe Ly - #s Val Thr Leu Asn Ser          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Ala Leu Leu Gln Arg Tyr Arg Val Arg Il - #e Arg Tyr Ala Ser Thr          #               575                                                            - Thr Asn Leu Arg Leu Phe Val Gln Asn Ser As - #n Asn Asp Phe Leu Val          #           590                                                                - Ile Tyr Ile Asn Lys Thr Met Asn Lys Asp As - #p Asp Leu Thr Tyr Gln          #       605                                                                    - Thr Phe Asp Leu Ala Thr Thr Asn Ser Asn Me - #t Gly Phe Ser Gly Asp          #   620                                                                        - Lys Asn Glu Leu Ile Ile Gly Ala Glu Ser Ph - #e Val Ser Asn Glu Lys          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Ile Tyr Ile Asp Lys Ile Glu Phe Ile Pro Va - #l Gln Leu                      #               650                                                            - (2) INFORMATION FOR SEQ ID NO:101:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 2050 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:101:                                - TGGAGCTCCA CCGCGGTGGC GGCCGCTCTA GAACTAGTGG ATCTAGGCCT CC - #ATATGAAC          60                                                                           - CCTAACAATC GTTCCGAACA CGACACCATC AAGGTTACTC CAAACTCTGA GT - #TGCAAACT         120                                                                           - AATCACAACC AGTACCCATT GGCTGACAAT CCTAACAGTA CTCTTGAGGA AC - #TTAACTAC         180                                                                           - AAGGAGTTTC TCCGGATGAC CGAAGATAGC TCCACTGAGG TTCTCGATAA CT - #CTACAGTG         240                                                                           - AAGGACGCTG TTGGAACTGG CATTAGCGTT GTGGGACAGA TTCTTGGAGT GG - #TTGGTGTT         300                                                                           - CCATTCGCTG GAGCTTTGAC CAGCTTCTAC CAGTCCTTTC TCAACACCAT CT - #GGCCTTCA         360                                                                           - GATGCTGATC CCTGGAAGGC TTTCATGGCC CAAGTGGAAG TCTTGATCGA TA - #AGAAGATC         420                                                                           - GAAGAGTATG CCAAGTCTAA AGCCTTGGCT GAGTTGCAAG GTTTGCAGAA CA - #ACTTCGAG         480                                                                           - GATTACGTCA ACGCACTCAA CAGCTGGAAG AAAACTCCCT TGAGTCTCAG GT - #CTAAGCGT         540                                                                           - TCCCAGGACC GTATTCGTGA ACTTTTCAGC CAAGCCGAAT CCCACTTCAG AA - #ACTCCATG         600                                                                           - CCTAGCTTTG CCGTTTCTAA GTTCGAGGTG CTCTTCTTGC CAACATACGC AC - #AAGCTGCC         660                                                                           - AACACTCATC TCTTGCTTCT CAAAGACGCT CAGGTGTTTG GTGAGGAATG GG - #GTTACTCC         720                                                                           - AGTGAAGATG TTGCCGAGTT CTACCATAGG CAGCTCAAGT TGACTCAACA GT - #ACACAGAC         780                                                                           - CACTGCGTCA ACTGGTACAA CGTTGGGCTC AATGGTCTTA GAGGATCTAC CT - #ACGACGCA         840                                                                           - TGGGTGAAGT TCAACAGGTT TCGTAGAGAG ATGACCTTGA CTGTGCTCGA TC - #TTATCGTT         900                                                                           - CTCTTTCCAT TCTACGACAT TCGTCTTTAC TCCAAAGGCG TTAAGACAGA GC - #TGACCAGA         960                                                                           - GACATCTTCA CCGATCCCAT CTTCTCACTT AACACCCTGC AGGAATACGG TC - #CAACTTTT        1020                                                                           - CTCTCCATTG AGAACAGCAT CAGGAAGCCT CACCTCTTCG ACTATCTGCA AG - #GCATTGAG        1080                                                                           - TTTCACACCA GGTTGCAACC TGGTTACTTC GGTAAGGATT CCTTCAACTA CT - #GGAGCGGA        1140                                                                           - AACTACGTTG AAACCAGACC ATCCATCGGA TCTAGCAAGA CCATCACTTC TC - #CATTCTAC        1200                                                                           - GGTGACAAGA GCACTGAGCC AGTGCAGAAG TTGAGCTTCG ATGGGCAGAA GG - #TGTATAGA        1260                                                                           - ACCATCGCCA ATACCGATGT TGCAGCTTGG CCTAATGGCA AGGTCTACCT TG - #GAGTTACT        1320                                                                           - AAAGTGGACT TCTCCCAATA CGACGATCAG AAGAACGAGA CATCTACTCA AA - #CCTACGAT        1380                                                                           - AGTAAGAGGA ACAATGGCCA TGTTTCCGCA CAAGACTCCA TTGACCAACT TC - #CACCTGAA        1440                                                                           - ACCACTGATG AACCATTGGA GAAGGCTTAC AGTCACCAAC TTAACTACGC CG - #AATGCTTT        1500                                                                           - CTCATGCAAG ACAGGCGTGG CACCATTCCG TTCTTTACAT GGACTCACAG GT - #CTGTCGAC        1560                                                                           - TTCTTTAACA CTATCGACGC TGAGAAGATT ACCCAACTTC CCGTGGTCAA GG - #CTTATGCC        1620                                                                           - TTGTCCAGCG GAGCTTCCAT CATTGAAGGT CCAGGCTTCA CCGGTGGCAA CT - #TGCTCTTC        1680                                                                           - CTTAAGGAGT CCAGCAACTC CATCGCCAAG TTCAAAGTGA CACTTAACTC AG - #CAGCCTTG        1740                                                                           - CTCCAACGTT ACAGGGTTCG TATCAGATAC GCAAGCACTA CCAATCTTCG CC - #TCTTTGTC        1800                                                                           - CAGAACAGCA ACAATGATTT CCTTGTCATC TACATCAACA AGACTATGAA CA - #AAGACGAT        1860                                                                           - GACCTCACCT ACAACACATT CGATCTTGCC ACTACCAATA GTAACATGGG AT - #TCTCTGGT        1920                                                                           - GACAAGAACG AGCTGATCAT AGGTGCTGAG AGCTTTGTCT CTAATGAGAA GA - #TTTACATA        1980                                                                           - GACAAGATCG AGTTCATTCC AGTTCAACTC TAATAGATCC CCCGGGCTGC AG - #GAATTCGA        2040                                                                           #      2050                                                                    - (2) INFORMATION FOR SEQ ID NO:102:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 2280 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:102:                                - TTAAAATTAA TTTTGTATAC TTTTCATTGT AATAATATGA TTTTAAAAAC GA - #AAAAGTGC          60                                                                           - ATATACAACT TATCAGGAGG GGGGGGATGC ACAAAGAAGA AAAGAATAAG AA - #GTGAATGT         120                                                                           - TTATAATGTT CAATAGTTTT ATGGGAAGGC ATTTTATCAG GTAGAAAGTT AT - #GTATTATG         180                                                                           - ATAAGAATGG GAGGAAGAAA AATGAATCCA AACAATCGAA GTGAACATGA TA - #CGATAAAG         240                                                                           - GTTACACCTA ACAGTGAATT GCAAACTAAC CATAATCAAT ATCCTTTAGC TG - #ACAATCCA         300                                                                           - AATTCAACAC TAGAAGAATT AAATTATAAA GAATTTTTAA GAATGACTGA AG - #ACAGTTCT         360                                                                           - ACGGAAGTGC TAGACAACTC TACAGTAAAA GATGCAGTTG GGACAGGAAT TT - #CTGTTGTA         420                                                                           - GGGCAGATTT TAGGTGTTGT AGGAGTTCCA TTTGCTGGGG CACTCACTTC AT - #TTTATCAA         480                                                                           - TCATTTCTTA ACACTATATG GCCAAGTGAT GCTGACCCAT GGAAGGCTTT TA - #TGGCACAA         540                                                                           - GTTGAAGTAC TGATAGATAA GAAAATAGAG GAGTATGCTA AAAGTAAAGC TC - #TTGCAGAG         600                                                                           - TTACAGGGTC TTCAAAATAA TTTCGAAGAT TATGTTAATG CGTTAAATTC CT - #GGAAGAAA         660                                                                           - ACACCTTTAA GTTTGCGAAG TAAAAGAAGC CAAGATCGAA TAAGGGAACT TT - #TTTCTCAA         720                                                                           - GCAGAAAGTC ATTTTCGTAA TTCCATGCCG TCATTTGCAG TTTCCAAATT CG - #AAGTGCTG         780                                                                           - TTTCTACCAA CATATGCACA AGCTGCAAAT ACACATTTAT TGCTATTAAA AG - #ATGCTCAA         840                                                                           - GTTTTTGGAG AAGAATGGGG ATATTCTTCA GAAGATGTTG CTGAATTTTA TC - #ATAGACAA         900                                                                           - TTAAAACTTA CACAACAATA CACTGACCAT TGTGTTAATT GGTATAATGT TG - #GATTAAAT         960                                                                           - GGTTTAAGAG GTTCAACTTA TGATGCATGG GTCAAATTTA ACCGTTTTCG CA - #GAGAAATG        1020                                                                           - ACTTTAACTG TATTAGATCT AATTGTACTT TTCCCATTTT ATGATATTCG GT - #TATACTCA        1080                                                                           - AAAGGGGTTA AAACAGAACT AACAAGAGAC ATTTTTACGG ATCCAATTTT TT - #CACTTAAT        1140                                                                           - ACTCTTCAGG AGTATGGACC AACTTTTTTG AGTATAGAAA ACTCTATTCG AA - #AACCTCAT        1200                                                                           - TTATTTGATT ATTTACAGGG GATTGAATTT CATACGCGTC TTCAACCTGG TT - #ACTTTGGG        1260                                                                           - AAAGATTCTT TCAATTATTG GTCTGGTAAT TATGTAGAAA CTAGACCTAG TA - #TAGGATCT        1320                                                                           - AGTAAGACAA TTACTTCCCC ATTTTATGGA GATAAATCTA CTGAACCTGT AC - #AAAAGCTA        1380                                                                           - AGCTTTGATG GACAAAAAGT TTATCGAACT ATAGCTAATA CAGACGTAGC GG - #CTTGGCCG        1440                                                                           - AATGGTAAGG TATATTTAGG TGTTACGAAA GTTGATTTTA GTCAATATGA TG - #ATCAAAAA        1500                                                                           - AATGAAACTA GTACACAAAC ATATGATTCA AAAAGAAACA ATGGCCATGT AA - #GTGCACAG        1560                                                                           - GATTCTATTG ACCAATTACC GCCAGAAACA ACAGATGAAC CACTTGAAAA AG - #CATATAGT        1620                                                                           - CATCAGCTTA ATTACGCGGA ATGTTTCTTA ATGCAGGACC GTCGTGGAAC AA - #TTCCATTT        1680                                                                           - TTTACTTGGA CACATAGAAG TGTAGACTTT TTTAATACAA TTGATGCTGA AA - #AGATTACT        1740                                                                           - CAACTTCCAG TAGTGAAAGC ATATGCCTTG TCTTCAGGTG CTTCCATTAT TG - #AAGGTCCA        1800                                                                           - GGATTCACAG GAGGAAATTT ACTATTCCTA AAAGAATCTA GTAATTCAAT TG - #CTAAATTT        1860                                                                           - AAAGTTACAT TAAATTCAGC AGCCTTGTTA CAACGATATC GTGTAAGAAT AC - #GCTATGCT        1920                                                                           - TCTACCACTA ACTTACGACT TTTTGTGCAA AATTCAAACA ATGATTTTCT TG - #TCATCTAC        1980                                                                           - ATTAATAAAA CTATGAATAA AGATGATGAT TTAACATATC AAACATTTGA TC - #TCGCAACT        2040                                                                           - ACTAATTCTA ATATGGGGTT CTCGGGTGAT AAGAATGAAC TTATAATAGG AG - #CAGAATCT        2100                                                                           - TTCGTTTCTA ATGAAAAAAT CTATATAGAT AAGATAGAAT TTATCCCAGT AC - #AATTGTAA        2160                                                                           - GGAGATTTTA AAATGTTGGG TGATGGTCAA AATGAAAGAA TAGGAAGGTG AA - #TTTTGATG        2220                                                                           - GTTAGGAAAG ATTCTTTTAA CAAAAGCAAC ATGGAAAAGT ATACAGTACA AA - #TATTAACC        2280                                                                           - (2) INFORMATION FOR SEQ ID NO:103:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 32 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:103:                                #          32      GCAA ACCCTAACAA TC                                          - (2) INFORMATION FOR SEQ ID NO:104:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 42 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:104:                                #  42              ACGA CCCTGCAGAA ATACGGTCCA AC                               - (2) INFORMATION FOR SEQ ID NO:105:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 28 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:105:                                #             28   CATT CGATCTTG                                               - (2) INFORMATION FOR SEQ ID NO:106:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 25 base                                                            (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:106:                                #               25 CAGC TCAAG                                                  - (2) INFORMATION FOR SEQ ID NO:107:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #pairs    (A) LENGTH: 1959 base                                                          (B) TYPE: nucleic acid                                                         (C) STRANDEDNESS: single                                                       (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:107:                                - ATGAATCCAA ACAATCGAAG TGAACATGAT ACGATAAAGG TTACACCTAA CA - #GTGAATTG          60                                                                           - CAAACTAACC ATAATCAATA TCCTTTAGCT GACAATCCAA ATTCAACACT AG - #AAGAATTA         120                                                                           - AATTATAAAG AATTTTTAAG AATGACTGAA GACAGTTCTA CGGAAGTGCT AG - #ACAACTCT         180                                                                           - ACAGTAAAAG ATGCAGTTGG GACAGGAATT TCTGTTGTAG GGCAGATTTT AG - #GTGTTGTA         240                                                                           - GGAGTTCCAT TTGCTGGGGC ACTCACTTCA TTTTATCAAT CATTTCTTAA CA - #CTATATGG         300                                                                           - CCAAGTGATG CTGACCCATG GAAGGCTTTT ATGGCACAAG TTGAAGTACT GA - #TAGATAAG         360                                                                           - AAAATAGAGG AGTATGCTAA AAGTAAAGCT CTTGCAGAGT TACAGGGTCT TC - #AAAATAAT         420                                                                           - TTCGAAGATT ATGTTAATGC GTTAAATTCC TGGAAGAAAA CACCTTTAAG TT - #TGCGAAGT         480                                                                           - AAAAGAAGCC AAGGTCGAAT AAGGGAACTT TTTTCTCAAG CAGAAAGTCA TT - #TTCGTAAT         540                                                                           - TCCATGCCGT CATTTGCAGT TTCCAAATTC GAAGTGCTGT TTCTACCAAC AT - #ATGCACAA         600                                                                           - GCTGCAAATA CACATTTATT GCTATTAAAA GATGCTCAAG TTTTTGGAGA AG - #AATGGGGA         660                                                                           - TATTCTTCAG AAGATGTTGC TGAATTCTAT CGTAGACAAT TAAAACTTAC AC - #AACAATAC         720                                                                           - ACTGACCATT GTGTTAATTG GTATAATGTT GGATTAAATG GTTTAAGAGG TT - #CAACTTAT         780                                                                           - GATGCATGGG TCAAATTTAA CCGTTTTCGC AGAGAAATGA CTTTAACTGT AT - #TAGATCTA         840                                                                           - ATTGTACTTT TCCCATTTTA TGATATTCGG TTATACTCAA AAGGGGTTAA AA - #CAGAACTA         900                                                                           - ACAAGAGACA TTTTTACGGA TCCAATTTTT TTACTTACTA CGCTTCAGAA GT - #ACGGACCA         960                                                                           - ACTTTTTTGA GTATAGAAAA CTCTATTCGA AAACCTCATT TATTTGATTA TT - #TACAGGGG        1020                                                                           - ATTGAATTTC ATACGCGTCT TCAACCTGGT TACTTTGGGA AAGATTCTTT CA - #ATTATTGG        1080                                                                           - TCTGGTAATT ATGTAGAAAC TAGACCTAGT ATAGGATCTA GTAAGACAAT TA - #CTTCCCCA        1140                                                                           - TTTTATGGAG ATAAATCTAC TGAACCTGTA CAAAAGCTAA GCTTTGATGG AC - #AAAAAGTT        1200                                                                           - TATCGAACTA TAGCTAATAC AGACGTAGCG GCTTGGCCGA ATGGTAAGGT AT - #ATTTAGGT        1260                                                                           - GTTACGAAAG TTGATTTTAG TCAATATGAT GATCAAAAAA ATGAAACTAG TA - #CACAAACA        1320                                                                           - TATGATTCAA AAAGAAACAA TGGCCATGTA AGTGCACAGG ATTCTATTGA CC - #AATTACCG        1380                                                                           - CCAGAAACAA CAGATGAACC ACTTGAAAAA GCATATAGTC ATCAGCTTAA TT - #ACGCGGAA        1440                                                                           - TGTTTCTTAA TGCAGGACCG TCGTGGAACA ATTCCATTTT TTACTTGGAC AC - #ATAGAAGT        1500                                                                           - GTAGACTTTT TTAATACAAT TGATGCTGAA AAGATTACTC AACTTCCAGT AG - #TGAAAGCA        1560                                                                           - TATGCCTTGT CTTCAGGTGC TTCCATTATT GAAGGTCCAG GATTCACAGG AG - #GAAATTTA        1620                                                                           - CTATTCCTAA AAGAATCTAG TAATTCAATT GCTAAATTTA AAGTTACATT AA - #ATTCAGCA        1680                                                                           - GCCTTGTTAC AACGATATCG TGTAAGAATA CGCTATGCTT CTACCACTAA CT - #TACGACTT        1740                                                                           - TTTGTGCAAA ATTCAAACAA TGATTTTCTT GTCATCTACA TTAATAAAAC TA - #TGAATAAA        1800                                                                           - GATGATGATT TAACATATCA AACATTTGAT CTCGCAACTA CTAATTCTAA TA - #TGGGGTTC        1860                                                                           - TCGGGTGATA AGAATGAACT TATAATAGGA GCAGAATCTT TCGTTTCTAA TG - #AAAAAATC        1920                                                                           #  1959            AATT TATCCCAGTA CAATTGTAA                                   - (2) INFORMATION FOR SEQ ID NO:108:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (C) STRANDEDNESS:                                                              (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:108:                                - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                15                                                            - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #            30                                                                - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #        45                                                                    - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #    60                                                                        - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          #80                                                                            - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                95                                                            - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Gly Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr Arg Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Leu Leu Thr Thr Le - #u Gln Lys Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:109:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 649 amino                                                          (B) TYPE: amino acid                                                           (C) STRANDEDNESS:                                                              (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:109:                                - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Ala Thr Glu          #                15                                                            - Asn Asn Glu Val Ser Asn Asn His Ala Gln Ty - #r Pro Leu Ala Asp Thr          #            30                                                                - Pro Thr Leu Glu Glu Leu Asn Tyr Lys Glu Ph - #e Leu Arg Arg Thr Thr          #        45                                                                    - Asp Asn Asn Val Glu Ala Leu Asp Ser Ser Th - #r Thr Lys Asp Ala Ile          #    60                                                                        - Gln Lys Gly Ile Ser Ile Ile Gly Asp Leu Le - #u Gly Val Val Gly Phe          #80                                                                            - Pro Tyr Gly Gly Ala Leu Val Ser Phe Tyr Th - #r Asn Leu Leu Asn Thr          #                95                                                            - Ile Trp Pro Gly Glu Asp Pro Leu Lys Ala Ph - #e Met Gln Gln Val Glu          #           110                                                                - Ala Leu Ile Asp Gln Lys Ile Ala Asp Tyr Al - #a Lys Asp Lys Ala Thr          #       125                                                                    - Ala Glu Leu Gln Gly Leu Lys Asn Val Phe Ly - #s Asp Tyr Val Ser Ala          #   140                                                                        - Leu Asp Ser Trp Asp Lys Thr Pro Leu Thr Le - #u Arg Asp Gly Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Al - #a Glu Ser His Phe Arg          #               175                                                            - Arg Ser Met Pro Ser Phe Ala Val Ser Gly Ty - #r Glu Val Leu Phe Leu          #           190                                                                - Pro Thr Tyr Ala Gln Ala Ala Asn Thr His Le - #u Leu Leu Leu Lys Asp          #       205                                                                    - Ala Gln Ile Tyr Gly Thr Asp Trp Gly Tyr Se - #r Thr Asp Asp Leu Asn          #   220                                                                        - Glu Phe His Thr Lys Gln Lys Asp Leu Thr Il - #e Glu Tyr Thr Asn His          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Cys Ala Lys Trp Tyr Lys Ala Gly Leu Asp Ly - #s Leu Arg Gly Ser Thr          #               255                                                            - Tyr Glu Glu Trp Val Lys Phe Asn Arg Tyr Ar - #g Arg Glu Met Thr Leu          #           270                                                                - Thr Val Leu Asp Leu Ile Thr Leu Phe Pro Le - #u Tyr Asp Val Arg Thr          #       285                                                                    - Tyr Thr Lys Gly Val Lys Thr Glu Leu Thr Ar - #g Asp Val Leu Thr Asp          #   300                                                                        - Pro Ile Val Ala Val Asn Asn Met Asn Gly Ty - #r Gly Thr Thr Phe Ser          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Le - #u Phe Asp Tyr Leu His          #               335                                                            - Ala Ile Gln Phe His Ser Arg Leu Gln Pro Gl - #y Tyr Phe Gly Thr Asp          #           350                                                                - Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Se - #r Thr Arg Ser Ser Ile          #       365                                                                    - Gly Ser Asp Glu Ile Ile Arg Ser Pro Phe Ty - #r Gly Asn Lys Ser Thr          #   380                                                                        - Leu Asp Val Gln Asn Leu Glu Phe Asn Gly Gl - #u Lys Val Phe Arg Ala          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Val Ala Asn Gly Asn Leu Ala Val Trp Pro Va - #l Gly Thr Gly Gly Thr          #               415                                                            - Lys Ile His Ser Gly Val Thr Lys Val Gln Ph - #e Ser Gln Tyr Asn Asp          #           430                                                                - Arg Lys Asp Glu Val Arg Thr Gln Thr Tyr As - #p Ser Lys Arg Asn Val          #       445                                                                    - Gly Gly Ile Val Phe Asp Ser Ile Asp Gln Le - #u Pro Pro Ile Thr Thr          #   460                                                                        - Asp Glu Ser Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Val Arg          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Leu Gln Gly Gly Arg Gly Ile Il - #e Pro Val Phe Thr Trp          #               495                                                            - Thr His Lys Ser Val Asp Phe Tyr Asn Thr Le - #u Asp Ser Glu Lys Ile          #           510                                                                - Thr Gln Ile Pro Phe Val Lys Ala Phe Ile Le - #u Val Asn Ser Thr Ser          #       525                                                                    - Val Val Ala Gly Pro Gly Phe Thr Gly Gly As - #p Ile Ile Lys Cys Thr          #   540                                                                        - Asn Gly Ser Gly Leu Thr Leu Tyr Val Thr Pr - #o Ala Pro Asp Leu Thr          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Tyr Ser Lys Thr Tyr Lys Ile Arg Ile Arg Ty - #r Ala Ser Thr Ser Gln          #               575                                                            - Val Arg Phe Gly Ile Asp Leu Gly Ser Tyr Th - #r His Ser Ile Ser Tyr          #           590                                                                - Phe Asp Lys Thr Met Asp Lys Gly Asn Thr Le - #u Thr Tyr Asn Ser Phe          #       605                                                                    - Asn Leu Ser Ser Val Ser Arg Pro Ile Glu Il - #e Ser Gly Gly Asn Lys          #   620                                                                        - Ile Gly Val Ser Val Gly Gly Ile Gly Ser Gl - #y Asp Glu Val Tyr Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Asp Lys Ile Glu Phe Ile Pro Met Asp                                                          645                                                            - (2) INFORMATION FOR SEQ ID NO:110:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (C) STRANDEDNESS:                                                              (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:110:                                - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                15                                                            - Asn Ser Glu Leu Pro Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #            30                                                                - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #        45                                                                    - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #    60                                                                        - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          #80                                                                            - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                95                                                            - Asp Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Val Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Ser          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Ile Tyr Phe Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Gly Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Ile Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Ile Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Thr          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:111:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (C) STRANDEDNESS:                                                              (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:111:                                - Met Asn Pro Asn Asn Arg Ser Glu His Asp Th - #r Ile Lys Val Thr Pro          #                15                                                            - Asn Ser Glu Leu Gln Thr Asn His Asn Gln Ty - #r Pro Leu Ala Asp Asn          #            30                                                                - Pro Asn Ser Thr Leu Glu Glu Leu Asn Tyr Ly - #s Glu Phe Leu Arg Met          #        45                                                                    - Thr Glu Asp Ser Ser Thr Glu Val Leu Asp As - #n Ser Thr Val Lys Asp          #    60                                                                        - Ala Val Gly Thr Gly Ile Ser Val Val Gly Gl - #n Ile Leu Gly Val Val          #80                                                                            - Gly Val Pro Phe Ala Gly Ala Leu Thr Ser Ph - #e Tyr Gln Ser Phe Leu          #                95                                                            - Asn Thr Ile Trp Pro Ser Asp Ala Asp Pro Tr - #p Lys Ala Phe Met Ala          #           110                                                                - Gln Val Glu Val Leu Ile Asp Lys Lys Ile Gl - #u Glu Tyr Ala Lys Ser          #       125                                                                    - Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln As - #n Asn Phe Glu Asp Tyr          #   140                                                                        - Val Asn Ala Leu Asn Ser Trp Lys Lys Thr Pr - #o Leu Ser Leu Arg Ser          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Arg Ser Gln Asp Arg Ile Arg Glu Leu Ph - #e Ser Gln Ala Glu Ser          #               175                                                            - His Phe Arg Asn Ser Met Pro Ser Phe Ala Va - #l Ser Lys Phe Glu Val          #           190                                                                - Leu Phe Leu Pro Thr Tyr Ala Gln Ala Ala As - #n Thr His Leu Leu Leu          #       205                                                                    - Leu Lys Asp Ala Gln Val Phe Gly Glu Glu Tr - #p Gly Tyr Ser Ser Glu          #   220                                                                        - Asp Val Ala Glu Phe Tyr His Arg Gln Leu Ly - #s Leu Thr Gln Gln Tyr          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Thr Asp His Cys Val Asn Trp Tyr Asn Val Gl - #y Leu Asn Gly Leu Arg          #               255                                                            - Gly Ser Thr Tyr Asp Ala Trp Val Lys Phe As - #n Arg Phe Arg Arg Glu          #           270                                                                - Met Thr Leu Thr Val Leu Asp Leu Ile Val Le - #u Phe Pro Phe Tyr Asp          #       285                                                                    - Ile Arg Leu Tyr Ser Lys Gly Val Lys Thr Gl - #u Leu Thr Arg Asp Ile          #   300                                                                        - Phe Thr Asp Pro Ile Phe Ser Leu Asn Thr Le - #u Gln Glu Tyr Gly Pro          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Thr Phe Leu Ser Ile Glu Asn Ser Ile Arg Ly - #s Pro His Leu Phe Asp          #               335                                                            - Tyr Leu Gln Gly Ile Glu Phe His Thr Arg Le - #u Gln Pro Gly Tyr Phe          #           350                                                                - Gly Lys Asp Ser Phe Asn Tyr Trp Ser Gly As - #n Tyr Val Glu Thr Arg          #       365                                                                    - Pro Ser Ile Gly Ser Ser Lys Thr Ile Thr Se - #r Pro Phe Tyr Gly Asp          #   380                                                                        - Lys Ser Thr Glu Pro Val Gln Lys Leu Ser Ph - #e Asp Gly Gln Lys Val          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Tyr Arg Thr Ile Ala Asn Thr Asp Val Ala Al - #a Trp Pro Asn Gly Lys          #               415                                                            - Val Tyr Leu Gly Val Thr Lys Val Asp Phe Se - #r Gln Tyr Asp Asp Gln          #           430                                                                - Lys Asn Glu Thr Ser Thr Gln Thr Tyr Asp Se - #r Lys Arg Asn Asn Gly          #       445                                                                    - His Val Ser Ala Gln Asp Ser Ile Asp Gln Le - #u Pro Pro Glu Thr Thr          #   460                                                                        - Asp Glu Pro Leu Glu Lys Ala Tyr Ser His Gl - #n Leu Asn Tyr Ala Glu          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Cys Phe Leu Met Gln Asp Arg Arg Gly Thr Il - #e Pro Phe Phe Thr Trp          #               495                                                            - Thr His Arg Ser Val Asp Phe Phe Asn Thr Il - #e Asp Ala Glu Lys Ile          #           510                                                                - Thr Gln Leu Pro Val Val Lys Ala Tyr Ala Le - #u Ser Ser Gly Ala Ser          #       525                                                                    - Ile Ile Glu Gly Pro Gly Phe Thr Gly Gly As - #n Leu Leu Phe Leu Lys          #   540                                                                        - Glu Ser Ser Asn Ser Ile Ala Lys Phe Lys Va - #l Thr Leu Asn Ser Ala          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Ala Leu Leu Gln Arg Tyr Arg Val Arg Ile Ar - #g Tyr Ala Ser Thr Thr          #               575                                                            - Asn Leu Arg Leu Phe Val Gln Asn Ser Asn As - #n Asp Phe Leu Val Ile          #           590                                                                - Tyr Ile Asn Lys Thr Met Asn Lys Asp Asp As - #p Leu Thr Tyr Gln Thr          #       605                                                                    - Phe Asp Leu Ala Thr Thr Asn Ser Asn Met Gl - #y Phe Ser Gly Asp Lys          #   620                                                                        - Asn Glu Leu Ile Ile Gly Ala Glu Ser Phe Va - #l Ser Asn Glu Lys Ile          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Tyr Ile Asp Lys Ile Glu Phe Ile Pro Val Gl - #n Leu                          #               650                                                            - (2) INFORMATION FOR SEQ ID NO:112:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 659 amino                                                          (B) TYPE: amino acid                                                           (C) STRANDEDNESS:                                                              (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:112:                                - Met Ile Arg Met Gly Gly Arg Lys Met Asn Pr - #o Asn Asn Arg Ser Glu          #                15                                                            - Tyr Asp Thr Ile Lys Val Thr Pro Asn Ser Gl - #u Leu Pro Thr Asn His          #            30                                                                - Asn Gln Tyr Pro Leu Ala Asp Asn Pro Asn Se - #r Thr Leu Glu Glu Leu          #        45                                                                    - Asn Tyr Lys Glu Phe Leu Arg Met Thr Ala As - #p Asn Ser Thr Glu Val          #    60                                                                        - Leu Asp Ser Ser Thr Val Lys Asp Ala Val Gl - #y Thr Gly Ile Ser Val          #80                                                                            - Val Gly Gln Ile Leu Gly Val Val Gly Val Pr - #o Phe Ala Gly Ala Leu          #                95                                                            - Thr Ser Phe Tyr Gln Ser Phe Leu Asn Ala Il - #e Trp Pro Ser Asp Ala          #           110                                                                - Asp Pro Trp Lys Ala Phe Met Ala Gln Val Gl - #u Val Leu Ile Asp Lys          #       125                                                                    - Lys Ile Glu Glu Tyr Ala Lys Ser Lys Ala Le - #u Ala Glu Leu Gln Gly          #   140                                                                        - Leu Gln Asn Asn Phe Glu Asp Tyr Val Asn Al - #a Leu Asp Ser Trp Lys          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Lys Ala Pro Val Asn Leu Arg Ser Arg Arg Se - #r Gln Asp Arg Ile Arg          #               175                                                            - Glu Leu Phe Ser Gln Ala Glu Ser His Phe Ar - #g Asn Ser Met Pro Ser          #           190                                                                - Phe Ala Val Ser Lys Phe Glu Val Leu Phe Le - #u Pro Thr Tyr Ala Gln          #       205                                                                    - Ala Ala Asn Thr His Leu Leu Leu Leu Lys As - #p Ala Gln Val Phe Gly          #   220                                                                        - Glu Glu Trp Gly Tyr Ser Ser Glu Asp Ile Al - #a Glu Phe Tyr Gln Arg          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Gln Leu Lys Leu Thr Gln Gln Tyr Thr Asp Hi - #s Cys Val Asn Trp Tyr          #               255                                                            - Asn Val Gly Leu Asn Ser Leu Arg Gly Ser Th - #r Tyr Asp Ala Trp Val          #           270                                                                - Lys Phe Asn Arg Phe Arg Arg Glu Met Thr Le - #u Thr Val Leu Asp Leu          #       285                                                                    - Ile Val Leu Phe Pro Phe Tyr Asp Val Arg Le - #u Tyr Ser Lys Gly Val          #   300                                                                        - Lys Thr Glu Leu Thr Arg Asp Ile Phe Thr As - #p Pro Ile Phe Thr Leu          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Asn Ala Leu Gln Glu Tyr Gly Pro Thr Phe Se - #r Ser Ile Glu Asn Ser          #               335                                                            - Ile Arg Lys Pro His Leu Phe Asp Tyr Leu Ar - #g Gly Ile Glu Phe His          #           350                                                                - Thr Arg Leu Arg Pro Gly Tyr Ser Gly Lys As - #p Ser Phe Asn Tyr Trp          #       365                                                                    - Ser Gly Asn Tyr Val Glu Thr Arg Pro Ser Il - #e Gly Ser Asn Asp Thr          #   380                                                                        - Ile Thr Ser Pro Phe Tyr Gly Asp Lys Ser Il - #e Glu Pro Ile Gln Lys          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Leu Ser Phe Asp Gly Gln Lys Val Tyr Arg Th - #r Ile Ala Asn Thr Asp          #               415                                                            - Ile Ala Ala Phe Pro Asp Gly Lys Ile Tyr Ph - #e Gly Val Thr Lys Val          #           430                                                                - Asp Phe Ser Gln Tyr Asp Asp Gln Lys Asn Gl - #u Thr Ser Thr Gln Thr          #       445                                                                    - Tyr Asp Ser Lys Arg Tyr Asn Gly Tyr Leu Gl - #y Ala Gln Asp Ser Ile          #   460                                                                        - Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pr - #o Leu Glu Lys Ala Tyr          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Ser His Gln Leu Asn Tyr Ala Glu Cys Phe Le - #u Met Gln Asp Arg Arg          #               495                                                            - Gly Thr Ile Pro Phe Phe Thr Trp Thr His Ar - #g Ser Val Asp Phe Phe          #           510                                                                - Asn Thr Ile Asp Ala Glu Lys Ile Thr Gln Le - #u Pro Val Val Lys Ala          #       525                                                                    - Tyr Ala Leu Ser Ser Gly Ala Ser Ile Ile Gl - #u Gly Pro Gly Phe Thr          #   540                                                                        - Gly Gly Asn Leu Leu Phe Leu Lys Glu Ser Se - #r Asn Ser Ile Ala Lys          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Phe Lys Val Thr Leu Asn Ser Ala Ala Leu Le - #u Gln Arg Tyr Arg Val          #               575                                                            - Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Ar - #g Leu Phe Val Gln Asn          #           590                                                                - Ser Asn Asn Asp Phe Leu Val Ile Tyr Ile As - #n Lys Thr Met Asn Ile          #       605                                                                    - Asp Gly Asp Leu Thr Tyr Gln Thr Phe Asp Ph - #e Ala Thr Ser Asn Ser          #   620                                                                        - Asn Met Gly Phe Ser Gly Asp Thr Asn Asp Ph - #e Ile Ile Gly Ala Glu          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Ser Phe Val Ser Asn Glu Lys Ile Tyr Ile As - #p Lys Ile Glu Phe Ile          #               655                                                            - Pro Val Gln                                                                  - (2) INFORMATION FOR SEQ ID NO:113:                                           -      (i) SEQUENCE CHARACTERISTICS:                                           #acids    (A) LENGTH: 652 amino                                                          (B) TYPE: amino acid                                                           (C) STRANDEDNESS:                                                              (D) TOPOLOGY: linear                                                 -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:113:                                - Met Ile Arg Lys Gly Gly Arg Lys Met Asn Pr - #o Asn Asn Arg Ser Glu          #                15                                                            - His Asp Thr Ile Lys Thr Thr Glu Asn Asn Gl - #u Val Pro Thr Asn His          #            30                                                                - Val Gln Tyr Pro Leu Ala Glu Thr Pro Asn Pr - #o Thr Leu Glu Asp Leu          #        45                                                                    - Asn Tyr Lys Glu Phe Leu Arg Met Thr Ala As - #p Asn Asn Thr Glu Ala          #    60                                                                        - Leu Asp Ser Ser Thr Thr Lys Asp Val Ile Gl - #n Lys Gly Ile Ser Val          #80                                                                            - Val Gly Asp Leu Leu Gly Val Val Gly Phe Pr - #o Phe Gly Gly Ala Leu          #                95                                                            - Val Ser Phe Tyr Thr Asn Phe Leu Asn Thr Il - #e Trp Pro Ser Glu Asp          #           110                                                                - Pro Trp Lys Ala Phe Met Glu Gln Val Glu Al - #a Leu Met Asp Gln Lys          #       125                                                                    - Ile Ala Asp Tyr Ala Lys Asn Lys Ala Leu Al - #a Glu Leu Gln Gly Leu          #   140                                                                        - Gln Asn Asn Val Glu Asp Tyr Val Ser Ala Le - #u Ser Ser Trp Gln Lys          145                 1 - #50                 1 - #55                 1 -        #60                                                                            - Asn Pro Val Ser Ser Arg Asn Pro His Ser Gl - #n Gly Arg Ile Arg Glu          #               175                                                            - Leu Phe Ser Gln Ala Glu Ser His Phe Arg As - #n Ser Met Pro Ser Phe          #           190                                                                - Ala Ile Ser Gly Tyr Glu Val Leu Phe Leu Th - #r Thr Tyr Ala Gln Ala          #       205                                                                    - Ala Asn Thr His Leu Phe Leu Leu Lys Asp Al - #a Gln Ile Tyr Gly Glu          #   220                                                                        - Glu Trp Gly Tyr Glu Lys Glu Asp Ile Ala Gl - #u Phe Tyr Lys Arg Gln          225                 2 - #30                 2 - #35                 2 -        #40                                                                            - Leu Lys Leu Thr Gln Glu Tyr Thr Asp His Cy - #s Val Lys Trp Tyr Asn          #               255                                                            - Val Gly Leu Asp Lys Leu Arg Gly Ser Ser Ty - #r Glu Ser Trp Val Asn          #           270                                                                - Phe Asn Arg Tyr Arg Arg Glu Met Thr Leu Th - #r Val Leu Asp Leu Ile          #       285                                                                    - Ala Leu Phe Pro Leu Tyr Asp Val Arg Leu Ty - #r Pro Lys Glu Val Lys          #   300                                                                        - Thr Glu Leu Thr Arg Asp Val Leu Thr Asp Pr - #o Ile Val Gly Val Asn          305                 3 - #10                 3 - #15                 3 -        #20                                                                            - Asn Leu Arg Gly Tyr Gly Thr Thr Phe Ser As - #n Ile Glu Asn Tyr Ile          #               335                                                            - Arg Lys Pro His Leu Phe Asp Tyr Leu His Ar - #g Ile Gln Phe His Thr          #           350                                                                - Arg Phe Gln Pro Gly Tyr Tyr Gly Asn Asp Se - #r Phe Asn Tyr Trp Ser          #       365                                                                    - Gly Asn Tyr Val Ser Thr Arg Pro Ser Ile Gl - #y Ser Asn Asp Ile Ile          #   380                                                                        - Thr Ser Pro Phe Tyr Gly Asn Lys Ser Ser Gl - #u Pro Val Gln Asn Leu          385                 3 - #90                 3 - #95                 4 -        #00                                                                            - Glu Phe Asn Gly Glu Lys Val Tyr Arg Ala Va - #l Ala Asn Thr Asn Leu          #               415                                                            - Ala Val Trp Pro Ser Ala Val Tyr Ser Gly Va - #l Thr Lys Val Glu Phe          #           430                                                                - Ser Gln Tyr Asn Asp Gln Thr Asp Glu Ala Se - #r Thr Gln Thr Tyr Asp          #       445                                                                    - Ser Lys Arg Asn Val Gly Ala Val Ser Trp As - #p Ser Ile Asp Gln Leu          #   460                                                                        - Pro Pro Glu Thr Thr Asp Glu Pro Leu Glu Ly - #s Gly Tyr Ser His Gln          465                 4 - #70                 4 - #75                 4 -        #80                                                                            - Leu Asn Tyr Val Met Cys Phe Leu Met Gln Gl - #y Ser Arg Gly Thr Ile          #               495                                                            - Pro Val Leu Thr Trp Thr His Lys Ser Val As - #p Phe Phe Asn Met Ile          #           510                                                                - Asp Ser Lys Lys Ile Thr Gln Leu Pro Leu Va - #l Lys Ala Tyr Lys Leu          #       525                                                                    - Gln Ser Gly Ala Ser Val Val Ala Gly Pro Ar - #g Phe Thr Gly Gly Asp          #   540                                                                        - Ile Ile Gln Cys Thr Glu Asn Gly Ser Ala Al - #a Thr Ile Tyr Val Thr          545                 5 - #50                 5 - #55                 5 -        #60                                                                            - Pro Asp Val Ser Tyr Ser Gln Lys Tyr Arg Al - #a Arg Ile His Tyr Ala          #               575                                                            - Ser Thr Ser Gln Ile Thr Phe Thr Leu Ser Le - #u Asp Gly Ala Pro Phe          #           590                                                                - Asn Gln Tyr Tyr Phe Asp Lys Thr Ile Asn Ly - #s Gly Asp Thr Leu Thr          #       605                                                                    - Tyr Asn Ser Phe Asn Leu Ala Ser Phe Ser Th - #r Pro Phe Glu Leu Ser          #   620                                                                        - Gly Asn Asn Leu Gln Ile Gly Val Thr Gly Le - #u Ser Ala Gly Asp Lys          625                 6 - #30                 6 - #35                 6 -        #40                                                                            - Val Tyr Ile Asp Lys Ile Glu Phe Ile Pro Va - #l Asn                          #               650                                                            __________________________________________________________________________ 

What is claimed is:
 1. A method for producing a modified Cry3* polypeptide having improved insecticidal activity or specificity, comprising:(a) obtaining a three-dimensional crystal structure of a Cry3 polypeptide; (b) locating in said crystal structure of said Cry3 polypeptide one or more regions of bound water, wherein said bound water forms a contiguous hydrated surface separated by no more than about 16 Å; (c) increasing the hydrophobicity of one or more amino acids of said Cry3 polypeptide in one or more of said regions; and (d) obtaining the modified Cry3* polypeptide so produced.
 2. The method of claim 1, wherein said modified Cry3* polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:14, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, and SEQ ID NO:54.
 3. A method for producing a modified Cry3B* polypeptide having improved insecticidal activity, or enhanced insecticidal specificity, comprising(a) obtaining a three-dimensional crystal structure of a Cry3B polypeptide; (b) identifying a loop region in said Cry3B polypeptide; (c) modifying one or more amino acids in said loop region of said Cry3B polypeptide to increase by hydrophobicity of one or more of said amino acids; and (d) obtaining the modified Cry3B* polypeptide so produced.
 4. The method of claim 3, wherein said modified Cry3B* polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:26, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, and SEQ ID NO:42.
 5. A method for increasing the mobility of channel forming helices of a Cry3 polypeptide, comprising disrupting one or more hydrogen bonds formed between a first amino acid of one of said channel forming helices and a second amino acid of said polypeptide, wherein said disrupting comprises replacing said first amino acid or said second amino acid with a third amino acid whose spatial distance bond angle is greater than about 3 Å, or whose spatial orientation is not equal to 180±60 degrees relative to the hydrogen bonding site of said first or said second amino acid.
 6. The method of claim 5, wherein said polypeptide having one or more disrupted hydrogen bonds comprises an amino acid sequence selected from the group consisting of SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:22, SEQ ID NO:40, and SEQ ID NO:42.
 7. A method for increasing the flexibility of a loop region in a channel forming domain of a Cry3 polypeptide, comprising:(a) obtaining a crystal structure of a Cry3 polypeptide having a loop region between adjacent α-helices; (b) identifying the amino acids comprising said loop region; (c) altering one or more of said amino acids in said loop region to reduce the steric hindrance in said region, wherein said altering increases flexibility of said loop region in said polypeptide; and (d) obtaining the polypeptide so produced.
 8. The method of claim 7, wherein said polypeptide having an altered loop region comprises an amino acid sequence selected from the group consisting of SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:48, and SEQ ID NO:54.
 9. A method of increasing the insecticidal activity of a Cry3B polypeptide, comprising reducing or eliminating binding of said polypeptide to a carbohydrate in a target insect gut, wherein said reducing or eliminating is accomplished by removal of one or more α-helices of domain 1 of said Cry3B polypeptide.
 10. The method claim 9, wherein said reducing or eliminating is accomplished by removal of α-helices α1, α2a/b, or α3.
 11. The method of claim 10, wherein said Cry3B polypeptide comprises the amino acid sequence of SEQ ID NO:70.
 12. The method of claim 9, wherein said reducing or eliminating is accomplished by replacing one or more amino acids within loop β1,α8, with one or more amino acids having increased hydrophobicity.
 13. The method of claim 12, wherein said Cry3B polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:16, SEQ ID NO:20, SEQ ID NO:22, and SEQ ID NO:34.
 14. The method of claim 9, wherein said reducing or eliminating is accomplished by replacing with any other amino acid, one or more amino acids selected from the group consisting of threonine 154, proline 155, leucine 156, and leucine
 158. 15. The method of claim 14, wherein said Cry3B polypeptide comprises the amino acid sequence of SEQ ID NO:2.
 16. A method of preparing a modified Cry3* polypeptide having improved insecticidal activity or enhanced insecticidal specificity when compared to an unmodified Cry3 polypeptide, said method comprising the steps of:(a) obtaining a crystal structure of a Cry3 polypeptide; (b) identifying from said crystal structure one or more surface-exposed amino acids in said Cry3 polypeptide; (c) randomly substituting one or more of said surface-exposed amino acids to obtain a plurality of mutated polypeptides, wherein at least 50% of said mutated polypeptides have diminished insecticidal activity, or reduced insecticidal specificity; (d) identifying from said plurality of mutated polypeptides a region of said Cry3 polypeptide for targeted mutagenesis; and (e) mutagenizing said region to obtain said modified Cry3* polypeptide having improved insecticidal activity or enhanced insecticidal specificity.
 17. The method of claim 16, further comprising determining the amino acid sequences of a plurality of mutated polypeptides having diminished activity or reduced insecticidal specificity, and identifying one or more amino acid residues required for said activity or specificity.
 18. A process for producing a Cry3* polypeptide having improved insecticidal activity, comprising:(a) obtaining a three-dimensional crystal structure of a Cry3 polypeptide; (b) determining the electrostatic surface distribution of said Cry3 polypeptide; (c) identifying at least one region of high electrostatic diversity in said Cry3 polypeptide; (d) modifying the electrostatic diversity of said region by altering one or more amino acids in said region; and (e) obtaining the Cry3* polypeptide so produced.
 19. The process of claim 18, wherein said electrostatic diversity is decreased relative to the electrostatic diversity of a native Cry3 polypeptide.
 20. The process of claim 19, wherein said Cry3* polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:14, SEQ ID NO:40, and SEQ ID NO:42.
 21. The process of claim 18, wherein said electrostatic diversity is increased relative to the electrostatic diversity of a native Cry3 polypeptide.
 22. The process of claim 21, wherein said Cry3* polypeptide comprises SEQ ID NO:28.
 23. A method of producing a Cry3* polypeptide having improved insecticidal activity, comprising:(a) obtaining a three-dimensional crystal structure of a Cry3 polypeptide; (b) identifying the presence of one or more metal binding sites in said Cry3 polypeptide; (c) altering one or more amino acids in one or more of said binding sites of said Cry3 polypeptide; and (d) obtaining an altered polypeptide, wherein said polypeptide has improved insecticidal activity.
 24. The method of claim 23, wherein said altering eliminates metal binding.
 25. The method of claim 24, wherein said Cry3* polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:4, SEQ ID NO:8, SEQ ID NO:10, and SEQ ID NO:12.
 26. A method of identifying a Cry3B polypeptide having improved channel activity, comprising:(a) obtaining a mutant Cry3B polypeptide; (b) determining the rate of channel formation in said mutant polypeptide, and in a wild-type polypeptide; (c) comparing said characteristics of said mutant polypeptide and said wild-type polypeptide; and (d) identifying said mutant polypeptide having an increased rate of channel formation compared to said wild-type polypeptide.
 27. The method of claim 26, wherein said mutant Cry3B polypeptide comprises an amino acid sequence selected from the group consisting SEQ ID NO:70, SEQ ID NO:46, SEQ ID NO:52, SEQ ID NO:24, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:12, SEQ ID NO:2, SEQ ID NO:42, and SEQ ID NO:20.
 28. A method for producing a modified Cry3B polypeptide, having improved insecticidal activity, comprising altering one or more non-surface amino acids located at a point of convergence of two or more loop regions of said Cry3B polypeptide, wherein said altering decreases the mobility of one or more of said loop regions.
 29. The method of claim 28, wherein said mobility is determined by comparing the thermal denaturation of said modified protein to a wild-type Cry3B polypeptide.
 30. The method of claim 28, wherein said modified Cry3B polypeptide comprises SEQ ID NO:67.
 31. The method of claim 28, wherein said modified Cry3B polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:22, and SEQ ID NO:30.
 32. A method of improving the insecticidal activity of a Cry3 polypeptide, said method comprising inserting one or more protease sensitive sites into one or more loop regions of domain 1 of said polypeptide.
 33. The method of claim 22, wherein said loop region is α3,4.
 34. The method of claim 33, wherein said modified Cry3B polypeptide comprises SEQ ID NO:2.
 35. A modified Cry3B* polypeptide prepared by a process comprising the steps of:(a) identifying a Cry3B polypeptide having one or more loop regions between two adjacent α helices; (b) introducing one or more mutations into at least one of said loop regions; and (c) obtaining the modified Cry3B* polypeptide so produced.
 36. The polypeptide of claim 35, wherein said polypeptide is selected from the group consisting of Cry3Bb-60, Cry3Bb.11221, Cry3Bb.11222, Cry3Bb.11223, Cry3Bb.11224, Cry3Bb.11225, Cry3Bb.11226, Cry3Bb.11227, Cry3Bb.11228, Cry3Bb.11229, Cry3Bb.11230, Cry3Bb.11231, Cry3Bb.11232, Cry3Bb.11233, Cry3Bb.11234, Cry3Bb.11235, Cry3Bb.11236, Cry3Bb.11237, Cry3Bb.11238, Cry3Bb.11239, Cry3Bb.11241, Cry3Bb.11242, Cry3Bb.11032, Cry3Bb.11235, Cry3Bb.11036, Cry3Bb.11046, Cry3Bb.11048, Cry3Bb.11051, Cry3Bb.11057, Cry3Bb.11058, Cry3Bb.11081, Cry3Bb.11082, Cry3Bb.11083, Cry3Bb.11084, Cry3Bb.11095, and Cry3Bb.11098.
 37. The polypeptide of claim 35, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, and SEQ ID NO:108.
 38. The polypeptide of claim 37, wherein said polypeptide is encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:99, and SEQ ID NO:107.
 39. The method of controlling or eradicating an insect population comprising contacting said insect population with an insecticidally-effective amount of a Cry3B* polypeptide composition, wherein:said composition is substantially free of intact cells, and said Cry3B* polypeptide in said composition has one or more loop regions between two adjacent α helices and one or more mutations in at least one of said loop regions.
 40. The method of claim 39, wherein said polypeptide is selected from the group consisting of Cry3Bb-60, Cry3Bb.11221, Cry3Bb.11222, Cry3Bb.11223, Cry3Bb.11224, Cry3Bb.11225, Cry3Bb.11226, Cry3Bb.11227, Cry3Bb.11228, Cry3Bb.11229, Cry3Bb.11230, Cry3Bb.11231, Cry3Bb.11232, Cry3Bb.11233, Cry3Bb.11234, Cry3Bb.11235, Cry3Bb.11236, Cry3Bb.11237, Cry3Bb.11238, Cry3Bb.11239, Cry3Bb.11241, Cry3Bb.11242, Cry3Bb.11032, Cry3Bb.11035, Cry3Bb.11036, Cry3Bb.11046, Cry3Bb.11048, Cry3Bb.11051, Cry3Bb.11057, Cry3Bb.11058, Cry3Bb.11081, Cry3Bb.11082, Cry3Bb.11083, Cry3Bb.11084, Cry3Bb.11095, and Cry3Bb.11098.
 41. The method of claim 39, wherein said Cry3* polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:100, and SEQ ID NO:108. 